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Conserved domains on  [gi|253795726|gb|ACT35687|]
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MIP12770p [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
31-208 6.90e-27

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.10  E-value: 6.90e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  31 DLADKGLSSFEELPGLFNMSNITRLTLSHNKISVISPGIANLLNLEILNLSNNQLTELPVSLSSMPKLRILNVSINRLIN 110
Cdd:COG4886   94 DLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTD 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726 111 LPRGFGAFPVLEVLDLSYNNLNEqvLPGNFFGMETLRALYLGDNDFEYIPKEVGQLKNLQILGLRDNDLLELPrEVGDLV 190
Cdd:COG4886  174 LPEELGNLTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLT 250

                        170
                 ....*....|....*...
gi 253795726 191 RLRELHIQNNRLQVLPPE 208
Cdd:COG4886  251 NLEELDLSNNQLTDLPPL 268
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
31-208 6.90e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.10  E-value: 6.90e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  31 DLADKGLSSFEELPGLFNMSNITRLTLSHNKISVISPGIANLLNLEILNLSNNQLTELPVSLSSMPKLRILNVSINRLIN 110
Cdd:COG4886   94 DLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTD 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726 111 LPRGFGAFPVLEVLDLSYNNLNEqvLPGNFFGMETLRALYLGDNDFEYIPKEVGQLKNLQILGLRDNDLLELPrEVGDLV 190
Cdd:COG4886  174 LPEELGNLTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLT 250

                        170
                 ....*....|....*...
gi 253795726 191 RLRELHIQNNRLQVLPPE 208
Cdd:COG4886  251 NLEELDLSNNQLTDLPPL 268
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 21-156 1.80e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.40  E-value: 1.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  21 EARETHNPELDLADKGLSSFE-ELPGLFNMSNITRLTLSHNKIS-VISPGIANLLNLEILNLSNNQLT-ELPVSLSSMPK 97
Cdd:PLN00113 445 NSRKWDMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKK 524

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  98 LRILNVSINRLI-NLPRGFGAFPVLEVLDLSYNNLNEQVlPGNFFGMETLRALYLGDNDF 156
Cdd:PLN00113 525 LVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSGEI-PKNLGNVESLVQVNISHNHL 583
LRR_8 pfam13855
Leucine rich repeat;
96-156 8.70e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 8.70e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 253795726   96 PKLRILNVSINRLINLPRG-FGAFPVLEVLDLSYNNLNeQVLPGNFFGMETLRALYLGDNDF 156
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLT-TLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 41-161 2.91e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 2.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  41 EELPGLFNMSNITRLTLSHNKISVISpGIAnllnleilnlSNNQLTEL----------------PVSLSSM-PKLRILNV 103
Cdd:cd21340   59 EKIENLENLVNLKKLYLGGNRISVVE-GLE----------NLTNLEELhienqrlppgekltfdPRSLAALsNSLRVLNI 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 253795726 104 SINRLINLpRGFGAFPVLEVLDLSYNNLNE-QVLPGNFFGMETLRALYLGDNDFEYIPK 161
Cdd:cd21340  128 SGNNIDSL-EPLAPLRNLEQLDASNNQISDlEELLDLLSSWPSLRELDLTGNPVCKKPK 185
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
31-208 6.90e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.10  E-value: 6.90e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  31 DLADKGLSSFEELPGLFNMSNITRLTLSHNKISVISPGIANLLNLEILNLSNNQLTELPVSLSSMPKLRILNVSINRLIN 110
Cdd:COG4886   94 DLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTD 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726 111 LPRGFGAFPVLEVLDLSYNNLNEqvLPGNFFGMETLRALYLGDNDFEYIPKEVGQLKNLQILGLRDNDLLELPrEVGDLV 190
Cdd:COG4886  174 LPEELGNLTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLT 250

                        170
                 ....*....|....*...
gi 253795726 191 RLRELHIQNNRLQVLPPE 208
Cdd:COG4886  251 NLEELDLSNNQLTDLPPL 268
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-205 8.41e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 8.41e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  29 ELDLADKGLSSFEElpGLFNMSNITRLTLSHNKISVISPGIANLLNLEILNLSNNQLTELPVSLSSMPKLRILNVSINRL 108
Cdd:COG4886  117 SLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQI 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726 109 INLPRGFGAFPVLEVLDLSYNNLNEqvLPGNFFGMETLRALYLGDNDFEYIPkEVGQLKNLQILGLRDNDLLELPrEVGD 188
Cdd:COG4886  195 TDLPEPLGNLTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLAN 270

                        170
                 ....*....|....*..
gi 253795726 189 LVRLRELHIQNNRLQVL 205
Cdd:COG4886  271 LTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-218 3.11e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 3.11e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  80 LSNN-----------------QLTELPVSLSSMPKLRILNVSINRLINLPRGFGAFPVLEVLDLSYNNLNEqvLPGNFFG 142
Cdd:COG4886  103 LSGNeelsnltnlesldlsgnQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTD--LPEELGN 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726 143 METLRALYLGDNDFEYIPKEVGQLKNLQILGLRDNDLLELPREVGDLVRLRELHIQNNRLQVLP-----PEIAQLDLLSN 217
Cdd:COG4886  181 LTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPelgnlTNLEELDLSNN 260


                 .
gi 253795726 218 K 218
Cdd:COG4886  261 Q 261
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
48-215 9.58e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.07  E-value: 9.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  48 NMSNITRLTLSHNKISVISPGIANLLNLEILNLSNNQLTELPVSLSSMPKLRILNVSINRLInlprgfGAFPVLEVLDLS 127
Cdd:COG4886   48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEEL------SNLTNLESLDLS 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726 128 YNNLNEqvLPGNFFGMETLRALYLGDNDFEYIPKEVGQLKNLQILGLRDNDLLELPREVGDLVRLRELHIQNNRLQVLPP 207
Cdd:COG4886  122 GNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE 199


                 ....*...
gi 253795726 208 EIAQLDLL 215
Cdd:COG4886  200 PLGNLTNL 207
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-219 4.12e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 4.12e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  29 ELDLADKGLSSFEElpGLFNMSNITRLTLSHNKISVISPGIANLLNLEILNLSNNQLTELPVSLSSMPKLRILNVSINRL 108
Cdd:COG4886  140 ELDLSNNQLTDLPE--PLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQL 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726 109 INLPRGFGAFPVLEVLDLSYNNLNEqvLPgNFFGMETLRALYLGDNDFEYIPKEvGQLKNLQILGLRDNDLLELPREVGD 188
Cdd:COG4886  218 TDLPEPLANLTNLETLDLSNNQLTD--LP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKELE 293

                        170       180       190
                 ....*....|....*....|....*....|.
gi 253795726 189 LVRLRELHIQNNRLQVLPPEIAQLDLLSNKS 219
Cdd:COG4886  294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 21-156 1.80e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.40  E-value: 1.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  21 EARETHNPELDLADKGLSSFE-ELPGLFNMSNITRLTLSHNKIS-VISPGIANLLNLEILNLSNNQLT-ELPVSLSSMPK 97
Cdd:PLN00113 445 NSRKWDMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKK 524

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  98 LRILNVSINRLI-NLPRGFGAFPVLEVLDLSYNNLNEQVlPGNFFGMETLRALYLGDNDF 156
Cdd:PLN00113 525 LVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSGEI-PKNLGNVESLVQVNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 44-203 2.59e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.02  E-value: 2.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  44 PGLFNMSNITRLTLSHNKIS-VISPGIANLLNLEILNLSNNQLT-ELPVSLSSMPKLRILNVSINRLI-NLPRGFGAFPV 120
Cdd:PLN00113 278 PSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNN 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726 121 LEVLDLSYNNLNEQvLPGNFFGMETLRALYLGDNDFE-YIPKEVGQLKNLQILGLRDNDLL-ELPREVGDLVRLRELHIQ 198
Cdd:PLN00113 358 LTVLDLSTNNLTGE-IPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDIS 436


                 ....*
gi 253795726 199 NNRLQ 203
Cdd:PLN00113 437 NNNLQ 441
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
84-237 4.25e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.10  E-value: 4.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  84 QLTELPVSLSSmpKLRILNVSINRLINLPRGFGAfpVLEVLDLSYNNLNeqVLPGNFfgMETLRALYLGDNDF----EYI 159
Cdd:PRK15370 231 QLTSIPATLPD--TIQEMELSINRITELPERLPS--ALQSLDLFHNKIS--CLPENL--PEELRYLSVYDNSIrtlpAHL 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726 160 PKEVGQL---------------KNLQILGLRDNDLLELPREVGDlvRLRELHIQNNRLQV----LPPEIAQLDlLSNKSV 220
Cdd:PRK15370 303 PSGITHLnvqsnsltalpetlpPGLKTLEAGENALTSLPASLPP--ELQVLDVSKNQITVlpetLPPTITTLD-VSRNAL 379

                        170
                 ....*....|....*..
gi 253795726 221 MKMEENPwvnPIAEQYL 237
Cdd:PRK15370 380 TNLPENL---PAALQIM 393
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 48-217 1.67e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 1.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  48 NMSNITRLTLSHNKIS-VISPGIANLLNLEILNLSNNQLT-ELPVSLS-SMPKLRILNVSINRLI-NLPRGFgaFPVLEV 123
Cdd:PLN00113  67 NSSRVVSIDLSGKNISgKISSAIFRLPYIQTINLSNNQLSgPIPDDIFtTSSSLRYLNLSNNNFTgSIPRGS--IPNLET 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726 124 LDLSyNNLNEQVLPGNFFGMETLRALYLGDNDFE-YIPKEVGQLKNLQILGLRDNDLL-ELPREVGDLVRLRELHIQNNR 201
Cdd:PLN00113 145 LDLS-NNMLSGEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNN 223

                        170
                 ....*....|....*..
gi 253795726 202 LQ-VLPPEIAQLDLLSN 217
Cdd:PLN00113 224 LSgEIPYEIGGLTSLNH 240
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 30-202 2.23e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.85  E-value: 2.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  30 LDLADKGLSSfeELP---GLFnmSNITRLTLSHNKIS-VISPGIANLLNLEILNLSNNQLT-ELPVSLSSMPKLRILNVS 104
Cdd:PLN00113 145 LDLSNNMLSG--EIPndiGSF--SSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLG 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726 105 INRLI-NLPRGFGAFPVLEVLDLSYNNLNEQV-----------------------LPGNFFGMETLRALYLGDNDFE-YI 159
Cdd:PLN00113 221 YNNLSgEIPYEIGGLTSLNHLDLVYNNLTGPIpsslgnlknlqylflyqnklsgpIPPSIFSLQKLISLDLSDNSLSgEI 300

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 253795726 160 PKEVGQLKNLQILGLRDNDLL-ELPREVGDLVRLRELHIQNNRL 202
Cdd:PLN00113 301 PELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKF 344
PLN03150 PLN03150
hypothetical protein; Provisional
 88-187 3.24e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 54.44  E-value: 3.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  88 LPVSLSSMPKLRILNVSINRLI-NLPRGFGAFPVLEVLDLSYNNLNEQvlpgnffgmetlralylgdndfeyIPKEVGQL 166
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGS------------------------IPESLGQL 489

                         90       100
                 ....*....|....*....|..
gi 253795726 167 KNLQILGLRDNDLL-ELPREVG 187
Cdd:PLN03150 490 TSLRILNLNGNSLSgRVPAALG 511
LRR_8 pfam13855
Leucine rich repeat;
96-156 8.70e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 8.70e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 253795726   96 PKLRILNVSINRLINLPRG-FGAFPVLEVLDLSYNNLNeQVLPGNFFGMETLRALYLGDNDF 156
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLT-TLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 41-161 2.91e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 2.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  41 EELPGLFNMSNITRLTLSHNKISVISpGIAnllnleilnlSNNQLTEL----------------PVSLSSM-PKLRILNV 103
Cdd:cd21340   59 EKIENLENLVNLKKLYLGGNRISVVE-GLE----------NLTNLEELhienqrlppgekltfdPRSLAALsNSLRVLNI 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 253795726 104 SINRLINLpRGFGAFPVLEVLDLSYNNLNE-QVLPGNFFGMETLRALYLGDNDFEYIPK 161
Cdd:cd21340  128 SGNNIDSL-EPLAPLRNLEQLDASNNQISDlEELLDLLSSWPSLRELDLTGNPVCKKPK 185
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 95-202 2.94e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 2.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  95 MPKLRILNVSINRLI-NLPRGFGAfPVLEVLDLSYNNLNEQVlPGNFFGMETLRALYLGDNDFE-YIPKEVGQLKNLQIL 172
Cdd:PLN00113 451 MPSLQMLSLARNKFFgGLPDSFGS-KRLENLDLSRNQFSGAV-PRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSL 528

                         90       100       110
                 ....*....|....*....|....*....|.
gi 253795726 173 GLRDNDLL-ELPREVGDLVRLRELHIQNNRL 202
Cdd:PLN00113 529 DLSHNQLSgQIPASFSEMPVLSQLDLSQNQL 559
LRR_8 pfam13855
Leucine rich repeat;
50-131 2.55e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 2.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726   50 SNITRLTLSHNKISVISPGianllnleilnlsnnqltelpvSLSSMPKLRILNVSINRLINL-PRGFGAFPVLEVLDLSY 128
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDG----------------------AFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSG 58


                  ...
gi 253795726  129 NNL 131
Cdd:pfam13855  59 NRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 22-200 3.03e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 3.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  22 ARETHnpeLDLADKGLSSFEEL-------------------PGLFNMSNITRLTLSHNKISVISPgianllnleilnlsn 82
Cdd:cd21340    2 KRITH---LYLNDKNITKIDNLslcknlkvlylydnkitkiENLEFLTNLTHLYLQNNQIEKIEN--------------- 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  83 nqltelpvsLSSMPKLRILNVSINRLINLpRGFGAFPVLEVLDLSYNNL-NEQVL---PGNFFGM-ETLRALYLGDNDFE 157
Cdd:cd21340   64 ---------LENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLpPGEKLtfdPRSLAALsNSLRVLNISGNNID 133

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 253795726 158 YIpKEVGQLKNLQILGLRDN---DLLELPREVGDLVRLRELHIQNN 200
Cdd:cd21340  134 SL-EPLAPLRNLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGN 178
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
29-206 1.59e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 39.76  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  29 ELDLADKGLSSFEELPglfnmSNITRLTLSHNKIS---VISPGIanllnlEILNLSNNQLTELPVSLSSMPKLRILNVSI 105
Cdd:PRK15387 266 ELSIFSNPLTHLPALP-----SGLCKLWIFGNQLTslpVLPPGL------QELSVSDNQLASLPALPSELCKLWAYNNQL 334

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726 106 NRLINLPRGfgafpvLEVLDLSYNNLNE-QVLPGNFFgmetlrALYLGDNDFEYIPKEVGQLKNLQILGLRDNDLLELPR 184
Cdd:PRK15387 335 TSLPTLPSG------LQELSVSDNQLASlPTLPSELY------KLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVLPS 402

                        170       180
                 ....*....|....*....|..
gi 253795726 185 EvgdlvrLRELHIQNNRLQVLP 206
Cdd:PRK15387 403 E------LKELMVSGNRLTSLP 418
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
84-172 3.59e-03

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 38.91  E-value: 3.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  84 QLTELPVSLSsmPKLRILNVSINRLINLPRGFGAfpVLEVLDLSYNNLNE--QVLPgNFF--GMETLRALylgdndFEYI 159
Cdd:PRK15370 357 QITVLPETLP--PTITTLDVSRNALTNLPENLPA--ALQIMQASRNNLVRlpESLP-HFRgeGPQPTRII------VEYN 425

                         90
                 ....*....|...
gi 253795726 160 PKEVGQLKNLQIL 172
Cdd:PRK15370 426 PFSERTIQNMQRL 438
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
30-163 3.68e-03

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 38.52  E-value: 3.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  30 LDLADKGLSSF-EELPglfnmSNITRLTLSHNKIS----VISPGIanllnlEILNLSNNQLTELPVSLSsmPKLRILNVS 104
Cdd:PRK15370 288 LSVYDNSIRTLpAHLP-----SGITHLNVQSNSLTalpeTLPPGL------KTLEAGENALTSLPASLP--PELQVLDVS 354

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726 105 INRLINLPRGFGafPVLEVLDLSYNNLNEqvLPGNF-FGMETLRALYlgdNDFEYIPKEV 163
Cdd:PRK15370 355 KNQITVLPETLP--PTITTLDVSRNALTN--LPENLpAALQIMQASR---NNLVRLPESL 407
LRR_8 pfam13855
Leucine rich repeat;
119-202 6.45e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 6.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253795726  119 PVLEVLDLSYNNLNEqVLPGNFFGMETLRALYLGDNdfeyipkevgqlkNLQILGlrdndllelPREVGDLVRLRELHIQ 198
Cdd:pfam13855   1 PNLRSLDLSNNRLTS-LDDGAFKGLSNLKVLDLSNN-------------LLTTLS---------PGAFSGLPSLRYLDLS 57


                  ....
gi 253795726  199 NNRL 202
Cdd:pfam13855  58 GNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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