|
Name |
Accession |
Description |
Interval |
E-value |
| MrcB |
COG0744 |
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ... |
99-719 |
0e+00 |
|
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440507 [Multi-domain] Cd Length: 630 Bit Score: 672.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 99 NYPRAGAKNPWRWIPSLRMIVGAMALMVLAGLgFAVWLYTDTEVPEPSDFALAQTSRVYYADGeTEMGQFSEVNRTELPA 178
Cdd:COG0744 2 AKPRRGKRLLRRLLGLLLLLLAVLVLAALAGL-VALYVADLPDPEELEDLALPQTSTIYDRDG-TLIATLGDENREWVPL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 179 DEIPDSVKQAVVASEDSSFYENRGVSPRGILRAVVNNLR-GGDRQGASTITMQYVERYYTGTETSYVGKAKEAIMALKID 257
Cdd:COG0744 80 DQIPPHLKDAVVAIEDRRFYEHGGVDPKGIARALVANLTaGGVVQGGSTITQQLVKNLFLSNERTLSRKLKEALLALKLE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 258 QEISKDEILSRYLNTIYFGRGAYGVQEASQAYFGKDAADITDAEAALLVAVIPAPSGYDPANSPKKSVSLWDRVITRQVG 337
Cdd:COG0744 160 RKYSKDEILELYLNTVYFGRGAYGIEAAAQYYFGKSASDLTLAEAALLAGLVKAPSYYDPYRNPEAAKERRNLVLDRMVE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 338 EGQMTPEEAD-ALEFPDTIEPKSENSLGGTKGYLLAQVRGELVAQgFTDDEINTGGFTIVSTVDPSIQENTVQAIED-MP 415
Cdd:COG0744 240 QGYITQAEADaAKAEPLTLVPPPNGAAAGKYPYFVDYVRRELEEL-LGEDDLYRGGLKIYTTLDPKLQKAAEKAVKNvLP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 416 EDRPENNRVGTVTIDPDTGAIRAMYGGPDYVAQAQNDATQSRMQAGSIFKTFTLIAALEDGFPLDSRWDGnSPKSFRGG- 494
Cdd:COG0744 319 EGKPGGLQAALVVVDPKTGEVLAMVGGRDYGKSQFNRATQAKRQPGSTFKPFVYAAALEQGYTPATTVDD-EPVTFPGGg 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 495 WEVNNFNNIDYGRVTLQKATTNSINTAYAEANIEIGPERTRDTAVKLGLPEKtpgLSADASNVLGSASPTVAEMAEVYAT 574
Cdd:COG0744 398 WSPKNYDGRYRGPVTLREALANSLNTPAVRLAQEVGLDKVVDTARRLGITSP---LDPNPSLALGTSEVSPLEMASAYAT 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 575 IAAGGMHRDSYIVESVTRPDGSSRYEHESEETRAMDEEVAINATVALQGPPTEGSARSLRtaMDGRPVAGKTGTSEKFRS 654
Cdd:COG0744 475 FANGGVYVEPHAITKVTDADGKVLYEAKPKCEQVISPEVAYLMTDMLQDVVTSGTGRAAR--LPGRPVAGKTGTTNDNRD 552
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 256561094 655 AWFVGFTPQLVTAVGMFQPgeDGSeqtlssfgGVQNITGGSHPTDIWGDIMSASLEGKEVLDFPG 719
Cdd:COG0744 553 AWFVGYTPQLVTAVWVGND--DNS--------PMGYVTGGSLPAPIWRDFMEAALEGLPVEDFPK 607
|
|
| PBP_1a_fam |
TIGR02074 |
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ... |
172-711 |
1.61e-144 |
|
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273955 [Multi-domain] Cd Length: 531 Bit Score: 437.46 E-value: 1.61e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 172 NRTELPADEIPDSVKQAVVASEDSSFYENRGVSPRGILRAVVNNLR-GGDRQGASTITMQYVERYYTGTETSYVGKAKEA 250
Cdd:TIGR02074 1 RREYVPIDDIPENLINAFLAIEDRRFYDHFGIDLKGIGRAAVANITsGRVLEGGSTITQQLAKNLYLTNERTITRKIQEA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 251 IMALKIDQEISKDEILSRYLNTIYFGRGAYGVQEASQAYFGKDAADITDAEAALLVAVIPAPSGYDPANSPKKSVSLWDR 330
Cdd:TIGR02074 81 LLALKLEQKLSKDEILELYLNRIYFGNGAYGIEAAAQFYFGKSVNDLTLAEAAMLAGLPKAPSAYNPFKNPERAKDRRNL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 331 VITRQVGEGQMTPEEAD-ALEFPDTIEPKSENSLGGTKGYLLAQVRGELVAQgfTDDEINTGGFTIVSTVDPSIQENTVQ 409
Cdd:TIGR02074 161 VLSNMVENGYITAEEAEeAINEPIQLYLQTKKSEQYKAPYFVDYVIQELEEE--YGEELYTGGLKIYTTLDLDAQKAAEK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 410 AIED-------MPEDRPEnnrVGTVTIDPDTGAIRAMYGGPDYVAQAQNDATQSRMQAGSIFKTFTLIAALEDGFPLDSR 482
Cdd:TIGR02074 239 VLNTglrvagrRDGDDLQ---AALVAIDPDTGAVRALVGGRDYGKSQFNRATQAKRQPGSTFKPFVYAAALEKGLTPATI 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 483 WDgNSPKSF--RGGWEVNNFNNIDYGRVTLQKATTNSINTAYAEANIEIGPERTRDTAVKLGLpekTPGLSADASNVLGS 560
Cdd:TIGR02074 316 VN-DEPITYngNGPWSPKNYGGGYRGNVTLRQALAQSRNIPAVRLLQEVGLDKVVALAKRFGI---TSPLDPVLSLALGT 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 561 ASPTVAEMAEVYATIAAGGMHRDSYIVESVTRPDGSSRYEHESEETRAMDEEVAINATVALQGPPTEGSARSLRTAmdGR 640
Cdd:TIGR02074 392 VEVSPLEMASAYAVFANGGKYVEPHGIRKIVDRDGKVIYENKPKTTQVISPATAYIMTDMLKGVVESGTGRSARLP--GR 469
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 256561094 641 PVAGKTGTSEKFRSAWFVGFTPQLVTAVGMfqpGEDGSEQTLSSfggvqnITGGSHPTDIWGDIMSASLEG 711
Cdd:TIGR02074 470 PVAGKTGTTQNWRDAWFVGYTPYYVTAVWV---GYDDKKTLGKS------GTGGGLAAPIWRDFMAEALKN 531
|
|
| Transgly |
pfam00912 |
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of ... |
163-334 |
1.13e-76 |
|
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.
Pssm-ID: 459993 [Multi-domain] Cd Length: 177 Bit Score: 246.66 E-value: 1.13e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 163 TEMGQFSEVNRTELPADEIPDSVKQAVVASEDSSFYENRGVSPRGILRAVVNNLRGGDR-QGASTITMQYVERYYTGTET 241
Cdd:pfam00912 3 TLLAELGEENREYVPLDDIPPALKNAVLAIEDRRFYEHGGVDPKGIARALLSNLRSGRIvQGGSTITQQLAKNLFLTPER 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 242 SYVGKAKEAIMALKIDQEISKDEILSRYLNTIYFGRGAYGVQEASQAYFGKDAADITDAEAALLVAVIPAPSGYDPANSP 321
Cdd:pfam00912 83 TLTRKLKEAVLALKLERRYSKDEILEAYLNTVYFGRGAYGIEAAARAYFGKDASDLTLAEAALLAGLPQAPSRYNPLRNP 162
|
170
....*....|...
gi 256561094 322 KKSVSLWDRVITR 334
Cdd:pfam00912 163 ERAKRRRNLVLDR 175
|
|
| mrcB |
PRK09506 |
bifunctional glycosyl transferase/transpeptidase; Reviewed |
173-695 |
9.14e-60 |
|
bifunctional glycosyl transferase/transpeptidase; Reviewed
Pssm-ID: 236544 [Multi-domain] Cd Length: 830 Bit Score: 218.49 E-value: 9.14e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 173 RTELPADEIPDSVKQAVVASEDSSFYENRGVSPRGILRAVVNNLRGGDR-QGASTITMQYVERYYTGTETSYVGKAKEAI 251
Cdd:PRK09506 211 RLFVPRSGFPDLLVDTLLATEDRHFYEHDGISLYSIGRAVLANLTAGRTvQGGSTLTQQLVKNLFLSNERSLWRKANEAY 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 252 MALKIDQEISKDEILSRYLNTIYFGRGA----YGVQEASQAYFGKDAADITDAEAALLVAVIPAPSGYDPANSPKKSVSL 327
Cdd:PRK09506 291 MALIMDARYSKDRILELYLNEVYLGQSGddqiRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASLYNPWRNPKLALER 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 328 WDRVITRQVGEGQMTPEEADALEF-PDTIEPKSenslggtkGYLLAQ------VRGELvaQGFTDDEINT-GGFTIVSTV 399
Cdd:PRK09506 371 RNLVLRLLQQQQIIDQELYDMLSArPLGVQPKG--------GVISPQpafmqmVRQEL--QAKLGDKVKDlSGVKIFTTL 440
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 400 DPSIQENTVQAIED-MPEDRPENN----RVGTVTIDPDTGAIRAMYGGPDYVAQAQNDATQSRMQAGSIFKTFTLIAALE 474
Cdd:PRK09506 441 DPVSQDAAEKAVEEgIPALKKQRKlsdlETAMVVVDRFSGEVRAMVGGSEPQFAGYNRAMQARRSIGSLAKPATYLTALS 520
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 475 --DGFPLDSrWDGNSPKSFR--GG--WEVNNFNNIDYGRVTLQKATTNSINTAYAEANIEIGPERTRDTAVKLGLPEKTp 548
Cdd:PRK09506 521 qpDKYRLNT-WIADAPISLRqpNGqvWSPQNDDRRFSGRVMLVDALTRSMNVPTVNLGMALGLPAVTDTWIKLGVPKDQ- 598
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 549 gLSADASNVLGSASPTVAEMAEVYATIAAGGMHRDSYIVESVTRPDGSSRYEHESEETRAMDEEVAINATVALQGPPTEG 628
Cdd:PRK09506 599 -LNPVPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIAEDGKVLYQSFPQAERAVPAQAAYLTLYTMQQVVQRG 677
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 256561094 629 SARSLRTAMDGRPVAGKTGTSEKFRSAWFVGFtpqlvtavgmfqpgeDGSEQTLSSFG----GVQNITGGS 695
Cdd:PRK09506 678 TGRQLGAKYPNLHLAGKTGTTNDLVDSWFAGI---------------DGKEVTITWVGrdnnQPTKLYGAS 733
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MrcB |
COG0744 |
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ... |
99-719 |
0e+00 |
|
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440507 [Multi-domain] Cd Length: 630 Bit Score: 672.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 99 NYPRAGAKNPWRWIPSLRMIVGAMALMVLAGLgFAVWLYTDTEVPEPSDFALAQTSRVYYADGeTEMGQFSEVNRTELPA 178
Cdd:COG0744 2 AKPRRGKRLLRRLLGLLLLLLAVLVLAALAGL-VALYVADLPDPEELEDLALPQTSTIYDRDG-TLIATLGDENREWVPL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 179 DEIPDSVKQAVVASEDSSFYENRGVSPRGILRAVVNNLR-GGDRQGASTITMQYVERYYTGTETSYVGKAKEAIMALKID 257
Cdd:COG0744 80 DQIPPHLKDAVVAIEDRRFYEHGGVDPKGIARALVANLTaGGVVQGGSTITQQLVKNLFLSNERTLSRKLKEALLALKLE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 258 QEISKDEILSRYLNTIYFGRGAYGVQEASQAYFGKDAADITDAEAALLVAVIPAPSGYDPANSPKKSVSLWDRVITRQVG 337
Cdd:COG0744 160 RKYSKDEILELYLNTVYFGRGAYGIEAAAQYYFGKSASDLTLAEAALLAGLVKAPSYYDPYRNPEAAKERRNLVLDRMVE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 338 EGQMTPEEAD-ALEFPDTIEPKSENSLGGTKGYLLAQVRGELVAQgFTDDEINTGGFTIVSTVDPSIQENTVQAIED-MP 415
Cdd:COG0744 240 QGYITQAEADaAKAEPLTLVPPPNGAAAGKYPYFVDYVRRELEEL-LGEDDLYRGGLKIYTTLDPKLQKAAEKAVKNvLP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 416 EDRPENNRVGTVTIDPDTGAIRAMYGGPDYVAQAQNDATQSRMQAGSIFKTFTLIAALEDGFPLDSRWDGnSPKSFRGG- 494
Cdd:COG0744 319 EGKPGGLQAALVVVDPKTGEVLAMVGGRDYGKSQFNRATQAKRQPGSTFKPFVYAAALEQGYTPATTVDD-EPVTFPGGg 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 495 WEVNNFNNIDYGRVTLQKATTNSINTAYAEANIEIGPERTRDTAVKLGLPEKtpgLSADASNVLGSASPTVAEMAEVYAT 574
Cdd:COG0744 398 WSPKNYDGRYRGPVTLREALANSLNTPAVRLAQEVGLDKVVDTARRLGITSP---LDPNPSLALGTSEVSPLEMASAYAT 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 575 IAAGGMHRDSYIVESVTRPDGSSRYEHESEETRAMDEEVAINATVALQGPPTEGSARSLRtaMDGRPVAGKTGTSEKFRS 654
Cdd:COG0744 475 FANGGVYVEPHAITKVTDADGKVLYEAKPKCEQVISPEVAYLMTDMLQDVVTSGTGRAAR--LPGRPVAGKTGTTNDNRD 552
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 256561094 655 AWFVGFTPQLVTAVGMFQPgeDGSeqtlssfgGVQNITGGSHPTDIWGDIMSASLEGKEVLDFPG 719
Cdd:COG0744 553 AWFVGYTPQLVTAVWVGND--DNS--------PMGYVTGGSLPAPIWRDFMEAALEGLPVEDFPK 607
|
|
| PBP_1a_fam |
TIGR02074 |
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ... |
172-711 |
1.61e-144 |
|
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273955 [Multi-domain] Cd Length: 531 Bit Score: 437.46 E-value: 1.61e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 172 NRTELPADEIPDSVKQAVVASEDSSFYENRGVSPRGILRAVVNNLR-GGDRQGASTITMQYVERYYTGTETSYVGKAKEA 250
Cdd:TIGR02074 1 RREYVPIDDIPENLINAFLAIEDRRFYDHFGIDLKGIGRAAVANITsGRVLEGGSTITQQLAKNLYLTNERTITRKIQEA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 251 IMALKIDQEISKDEILSRYLNTIYFGRGAYGVQEASQAYFGKDAADITDAEAALLVAVIPAPSGYDPANSPKKSVSLWDR 330
Cdd:TIGR02074 81 LLALKLEQKLSKDEILELYLNRIYFGNGAYGIEAAAQFYFGKSVNDLTLAEAAMLAGLPKAPSAYNPFKNPERAKDRRNL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 331 VITRQVGEGQMTPEEAD-ALEFPDTIEPKSENSLGGTKGYLLAQVRGELVAQgfTDDEINTGGFTIVSTVDPSIQENTVQ 409
Cdd:TIGR02074 161 VLSNMVENGYITAEEAEeAINEPIQLYLQTKKSEQYKAPYFVDYVIQELEEE--YGEELYTGGLKIYTTLDLDAQKAAEK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 410 AIED-------MPEDRPEnnrVGTVTIDPDTGAIRAMYGGPDYVAQAQNDATQSRMQAGSIFKTFTLIAALEDGFPLDSR 482
Cdd:TIGR02074 239 VLNTglrvagrRDGDDLQ---AALVAIDPDTGAVRALVGGRDYGKSQFNRATQAKRQPGSTFKPFVYAAALEKGLTPATI 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 483 WDgNSPKSF--RGGWEVNNFNNIDYGRVTLQKATTNSINTAYAEANIEIGPERTRDTAVKLGLpekTPGLSADASNVLGS 560
Cdd:TIGR02074 316 VN-DEPITYngNGPWSPKNYGGGYRGNVTLRQALAQSRNIPAVRLLQEVGLDKVVALAKRFGI---TSPLDPVLSLALGT 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 561 ASPTVAEMAEVYATIAAGGMHRDSYIVESVTRPDGSSRYEHESEETRAMDEEVAINATVALQGPPTEGSARSLRTAmdGR 640
Cdd:TIGR02074 392 VEVSPLEMASAYAVFANGGKYVEPHGIRKIVDRDGKVIYENKPKTTQVISPATAYIMTDMLKGVVESGTGRSARLP--GR 469
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 256561094 641 PVAGKTGTSEKFRSAWFVGFTPQLVTAVGMfqpGEDGSEQTLSSfggvqnITGGSHPTDIWGDIMSASLEG 711
Cdd:TIGR02074 470 PVAGKTGTTQNWRDAWFVGYTPYYVTAVWV---GYDDKKTLGKS------GTGGGLAAPIWRDFMAEALKN 531
|
|
| MrcA |
COG5009 |
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis]; |
109-731 |
5.22e-135 |
|
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 444033 [Multi-domain] Cd Length: 785 Bit Score: 421.11 E-value: 5.22e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 109 WRWIpslrMIVGAMALMVLAGLGFAVWLYTDTEVPEPS---DFALAQTSRVYYADGEtEMGQFSEVNRTELPADEIPDSV 185
Cdd:COG5009 4 LKIL----LILLLLLLLLGALAVAGLYLYLSPDLPDVEtlkDYQPPTPSRVYSADGK-LIAEFGEERRIPVPIEEIPPLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 186 KQAVVASEDSSFYENRGVSPRGILRAVVNNLRGGDR-QGASTITMQYVERYYTGTETSYVGKAKEAIMALKIDQEISKDE 264
Cdd:COG5009 79 INAFLAAEDKRFYEHPGVDPIGIARAAVVNLRTGRRvQGGSTITQQVAKNFLLSPERTLTRKIKEAILALRIEQELSKDE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 265 ILSRYLNTIYFGRGAYGVQEASQAYFGKDAADITDAEAALLVAVIPAPSGYDPANSPKKSVslwDR---VITRQVGEGQM 341
Cdd:COG5009 159 ILELYLNKIYLGHRAYGVAAAAQTYFGKSLDELTLAEAAMLAGLPKAPSRYNPIRNPERAL---ERrnyVLGRMLELGYI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 342 TPEEAD-ALEFPDTIEPKSENSLgGTKGYLLAQVRGELVAQgFTDDEINTGGFTIVSTVDPSIQ---------------- 404
Cdd:COG5009 236 TQAEYEaAKAEPLTARYHGASAE-VDAPYFAEMVRRELVER-YGEDALYTGGLKVYTTLDPRLQeaaekalrdgllaydr 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 405 ---------------ENTVQAIEDMPEDRP------------------ENNRVGT------------------------- 426
Cdd:COG5009 314 rhgyrgpeahldlaeEDWDEALAEVPDVGDlrpavvlevddksarvglRDGETGTlpleglkwarpyindnrrgpapksa 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 427 --------------------------------VTIDPDTGAIRAMYGGPDYvAQAQ-NDATQSRMQAGSIFKTFTLIAAL 473
Cdd:COG5009 394 sdvlkpgdvirvrpvadggwrlrqipevqgalVALDPHTGAVLALVGGFDF-EQSKfNRATQAKRQPGSSFKPFVYAAAL 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 474 EDGFPLDSRWDgNSPKSFRGG-----WEVNNFNNIDYGRVTLQKATTNSINTAYAEANIEIGPERTRDTAVKLGLPEKtp 548
Cdd:COG5009 473 DNGYTPATIIN-DAPIVFDDGggggvWRPKNYSGKFYGPTTLREALEKSRNLVTVRLLQDVGIDYVIDYAERFGIYSK-- 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 549 gLSADASNVLGSASPTVAEMAEVYATIAAGGMHRDSYIVESVTRPDGSSRYEHESEE---------------------TR 607
Cdd:COG5009 550 -LPPNLSLALGSGEVTPLEMARAYAVFANGGYRVEPYLIDRIEDRNGKVIYRADPARacedcdaaewdgaeprlpdpaEQ 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 608 AMDEEVAINATVALQGPPTEGSARSLRTAmdGRPVAGKTGTSEKFRSAWFVGFTPQLVTA--VGMFQPgedgseqtlSSF 685
Cdd:COG5009 629 VIDPRTAYQMTSMLRGVVQRGTGRRARAL--GRDIAGKTGTTNDSKDAWFVGFTPDLVAGvwVGFDDP---------RSL 697
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|.
gi 256561094 686 GgvQNITGGSHPTDIWGDIMSASLEGKEVLDFP---G--QVRLDNETRERS 731
Cdd:COG5009 698 G--RGETGGRAALPIWIDFMKAALKDKPEKPFPvpeGivTVRIDPKTGLLA 746
|
|
| Transgly |
pfam00912 |
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of ... |
163-334 |
1.13e-76 |
|
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.
Pssm-ID: 459993 [Multi-domain] Cd Length: 177 Bit Score: 246.66 E-value: 1.13e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 163 TEMGQFSEVNRTELPADEIPDSVKQAVVASEDSSFYENRGVSPRGILRAVVNNLRGGDR-QGASTITMQYVERYYTGTET 241
Cdd:pfam00912 3 TLLAELGEENREYVPLDDIPPALKNAVLAIEDRRFYEHGGVDPKGIARALLSNLRSGRIvQGGSTITQQLAKNLFLTPER 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 242 SYVGKAKEAIMALKIDQEISKDEILSRYLNTIYFGRGAYGVQEASQAYFGKDAADITDAEAALLVAVIPAPSGYDPANSP 321
Cdd:pfam00912 83 TLTRKLKEAVLALKLERRYSKDEILEAYLNTVYFGRGAYGIEAAARAYFGKDASDLTLAEAALLAGLPQAPSRYNPLRNP 162
|
170
....*....|...
gi 256561094 322 KKSVSLWDRVITR 334
Cdd:pfam00912 163 ERAKRRRNLVLDR 175
|
|
| PbpC |
COG4953 |
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope ... |
110-718 |
2.31e-75 |
|
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 443980 [Multi-domain] Cd Length: 773 Bit Score: 261.69 E-value: 2.31e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 110 RWIPSLRMIVGAMALMVLAGLGFAVWLYTdteVPEPSDFALAQTSRVYYADGETeMGQF---SEVNRTELPADEIPDSVK 186
Cdd:COG4953 3 RARLRRRRLLALLLALLLLALALWALDRL---FPLPLLFAVPYSTVVLDRDGTL-LRAFlaaDGQWRLPVPLDEVSPRYL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 187 QAVVASEDSSFYENRGVSPRGILRAVVNNLRGGDR-QGASTITMQyVERYYTGTETSYVGKAKEAIMALKIDQEISKDEI 265
Cdd:COG4953 79 QALLAYEDRRFYYHPGVNPLALLRAAWQNLRSGRIvSGGSTLTMQ-VARLLEPRPRTLSGKLRQILRALQLERRYSKDEI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 266 LSRYLNTIYFGRGAYGVQEASQAYFGKDAADITDAEAALLvAVIP-APSGYDPANSPKKSVSLWDRVITRQVGEGQMTPE 344
Cdd:COG4953 158 LELYLNLAPYGGNIEGVEAASLAYFGKPPSRLSLAEAALL-AVLPqAPSRRRPDRNPERARAARDRVLARLAEAGVIDAE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 345 EA-DALEfpdtiEPksenslggtkgylLAQVRGEL----------VAQGFTDDEIntggftIVSTVDPSIQentvQAIED 413
Cdd:COG4953 237 EAaLALL-----EP-------------VPARRRPLpqlaphlarrLLRQLPGGTR------IRTTLDAGLQ----RRLER 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 414 MPEDRPENNRVGTVT------IDPDTGAIRAMYGGPDYVAQA---QNDATQSRMQAGSIFKTFTLIAALEDGF--Pldsr 482
Cdd:COG4953 289 LVRRYVRRLKQNGIHnaavlvVDNRTGEVLAYVGSADFFDASrqgQVDMVRALRSPGSTLKPFLYGLALDQGLihP---- 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 483 wdgNS-----PKSFrGGWEVNNFNNIDYGRVTLQKATTNSIntayaeaNI-------EIGPERTRDTAVKLGL-----PE 545
Cdd:COG4953 365 ---ETlladvPTSF-GGYRPENFDGTFQGPVSAREALARSL-------NIpavrlleALGPARFYARLRRAGLrlllpPA 433
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 546 KTPGLSAdasnVLGSASPTVAEMAEVYATIAAGGMHRdsyivESVTRPDGSsryehESEETRAMDEEVAINATVALQGPP 625
Cdd:COG4953 434 EHYGLSL----ILGGAEVTLEELVGLYAALARGGEAR-----PLRLLAGEP-----ASPGRRLLSPGAAWLVRDILSDVP 499
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 626 TEGSARSLRTAMDGRPVAGKTGTSEKFRSAWFVGFTPQLVTAV--GMFqpgeDGSeqtlssfgGVQNITGGSHPTDIWGD 703
Cdd:COG4953 500 RPDGAFGWRALDSPPPIAWKTGTSYGFRDAWAVGFTGRYTVGVwvGNP----DGT--------PVPGLTGAEAAAPLLFD 567
|
650
....*....|....*
gi 256561094 704 IMSASLEGKEVLDFP 718
Cdd:COG4953 568 IFDLLPASRWPLPFP 582
|
|
| PBP_1c |
TIGR02073 |
penicillin-binding protein 1C; This subfamily of the penicillin binding proteins includes the ... |
143-668 |
1.13e-63 |
|
penicillin-binding protein 1C; This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273954 [Multi-domain] Cd Length: 727 Bit Score: 228.07 E-value: 1.13e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 143 PEPSDFALaQTSRVYYADGETEMGQF-SEVNRTELPAD--EIPDSVKQAVVASEDSSFYENRGVSPRGILRAVVNNLRGG 219
Cdd:TIGR02073 1 PPPLLFHR-PSSTVVLDRHGTLLRALlANDGQWRLPVPleDISPKFLQALLLYEDKRFYWHPGVNPLALLRAAWQNLTNG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 220 DR-QGASTITMQYVERYYTGTETSYVGKAKEAIMALKIDQEISKDEILSRYLNTIYFGRGAYGVQEASQAYFGKDAADIT 298
Cdd:TIGR02073 80 RRvSGGSTLTMQLARLLDPELSRTLTGKLRQMWRAIQLEARYSKREILEAYLNLAPYGGNLEGLRAASLIYFGKEPSSLS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 299 DAEAALLVAVIPAPSGYDPANSPKKSVSLWDRVITRQVGEGQMTPEE-ADALEFPDTIEPKSENSLGGTKGYLLAQVRGE 377
Cdd:TIGR02073 160 LAEAALLAALPQAPSARRLDRLPKAAKAARDRLLDRMVEQGPDDSEQvALAALEPLPALPEPLPQLAPHFALKLLRARPE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 378 LVAqgftddeintggfTIVSTVDPSIQentvQAIEDMPED-----RPENNR-VGTVTIDPDTGAIRAMYGGPDYV---AQ 448
Cdd:TIGR02073 240 IAS-------------VIVSTLDADLQ----RRLEELARRylsalRPRGISnLAILVVDNRSGAVLAYVGSADFFddsNS 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 449 AQNDATQSRMQAGSIFKTFTLIAALEDGFPL-DSRWDgNSPKSFrGGWEVNNFNNIDYGRVTLQKATTNSINTAYAEANI 527
Cdd:TIGR02073 303 GQVDGVRAPRSPGSTLKPFLYALALDDGLLHpDSLLK-DVPLRF-GDYAPENFDKTFHGPVPAREALARSLNIPAVRLLE 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 528 EIGPERTRDTAVKLGLPEKTP-----GLSAdasnVLGSASPTVAEMAEVYATIAAGGM-HRDSYIVESVTRPdgssryeh 601
Cdd:TIGR02073 381 RVGPPRFADFLRQAGLNLLKPksdyyGLSL----ALGGAEITLQDLANLYAMLANQGLsGPLRFLQTDAKRP-------- 448
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 602 esEETRAMDEEVA-INATVALQGPPTEGSA--RSLRTAMdgrPVAGKTGTSEKFRSAWFVGFTPQLVTAV 668
Cdd:TIGR02073 449 --ERERLLSPGAAwIVLDILKDRPRPDDTLplSALPTRL---PLAWKTGTSYGFRDAWAAGVSGRYTIGV 513
|
|
| mrcB |
PRK09506 |
bifunctional glycosyl transferase/transpeptidase; Reviewed |
173-695 |
9.14e-60 |
|
bifunctional glycosyl transferase/transpeptidase; Reviewed
Pssm-ID: 236544 [Multi-domain] Cd Length: 830 Bit Score: 218.49 E-value: 9.14e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 173 RTELPADEIPDSVKQAVVASEDSSFYENRGVSPRGILRAVVNNLRGGDR-QGASTITMQYVERYYTGTETSYVGKAKEAI 251
Cdd:PRK09506 211 RLFVPRSGFPDLLVDTLLATEDRHFYEHDGISLYSIGRAVLANLTAGRTvQGGSTLTQQLVKNLFLSNERSLWRKANEAY 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 252 MALKIDQEISKDEILSRYLNTIYFGRGA----YGVQEASQAYFGKDAADITDAEAALLVAVIPAPSGYDPANSPKKSVSL 327
Cdd:PRK09506 291 MALIMDARYSKDRILELYLNEVYLGQSGddqiRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASLYNPWRNPKLALER 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 328 WDRVITRQVGEGQMTPEEADALEF-PDTIEPKSenslggtkGYLLAQ------VRGELvaQGFTDDEINT-GGFTIVSTV 399
Cdd:PRK09506 371 RNLVLRLLQQQQIIDQELYDMLSArPLGVQPKG--------GVISPQpafmqmVRQEL--QAKLGDKVKDlSGVKIFTTL 440
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 400 DPSIQENTVQAIED-MPEDRPENN----RVGTVTIDPDTGAIRAMYGGPDYVAQAQNDATQSRMQAGSIFKTFTLIAALE 474
Cdd:PRK09506 441 DPVSQDAAEKAVEEgIPALKKQRKlsdlETAMVVVDRFSGEVRAMVGGSEPQFAGYNRAMQARRSIGSLAKPATYLTALS 520
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 475 --DGFPLDSrWDGNSPKSFR--GG--WEVNNFNNIDYGRVTLQKATTNSINTAYAEANIEIGPERTRDTAVKLGLPEKTp 548
Cdd:PRK09506 521 qpDKYRLNT-WIADAPISLRqpNGqvWSPQNDDRRFSGRVMLVDALTRSMNVPTVNLGMALGLPAVTDTWIKLGVPKDQ- 598
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 549 gLSADASNVLGSASPTVAEMAEVYATIAAGGMHRDSYIVESVTRPDGSSRYEHESEETRAMDEEVAINATVALQGPPTEG 628
Cdd:PRK09506 599 -LNPVPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIAEDGKVLYQSFPQAERAVPAQAAYLTLYTMQQVVQRG 677
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 256561094 629 SARSLRTAMDGRPVAGKTGTSEKFRSAWFVGFtpqlvtavgmfqpgeDGSEQTLSSFG----GVQNITGGS 695
Cdd:PRK09506 678 TGRQLGAKYPNLHLAGKTGTTNDLVDSWFAGI---------------DGKEVTITWVGrdnnQPTKLYGAS 733
|
|
| mrcA |
PRK11636 |
penicillin-binding protein 1a; Provisional |
117-711 |
1.87e-50 |
|
penicillin-binding protein 1a; Provisional
Pssm-ID: 183248 [Multi-domain] Cd Length: 850 Bit Score: 191.11 E-value: 1.87e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 117 MIVGAMALMVLAGLGFAVWLYTDTEVPEPS---DFALAQTSRVYYADGETeMGQFSEVNRTELPADEIPDSVKQAVVASE 193
Cdd:PRK11636 8 LILAVCCILLGAGSIYGLYRYIEPQLPDVAtlkDVRLQTPMQVYSADGEL-IAQYGEKRRIPLTLDQIPPEMVKAFIATE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 194 DSSFYENRGVSPRGILRAVVNNLRGGD-RQGASTITMQYVERYYTGTETSYVGKAKEAIMALKIDQEISKDEILSRYLNT 272
Cdd:PRK11636 87 DSRFYEHHGVDPVGIFRAASVALFSGHaSQGASTITQQLARNFFLSPERTLMRKIKEAFLAIRIEQLLTKDEILELYLNK 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 273 IYFGRGAYGVQEASQAYFGKDAADITDAEAALLVAVIPAPSGYDPANSPKKSVSLWDRVITRQVGEGQMTPEEADALEFP 352
Cdd:PRK11636 167 IYLGYRAYGVGAAAQVYFGKTVDQLTLSEMAVIAGLPKAPSTFNPLYSMDRAVARRNVVLSRMLDEGYITQAQYDQARSE 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 353 DTIEPKSENSLGGTKGYLLAQVRGELVA----QGFTDdeintgGFTIVSTVDPSIQENTVQAIE------DM-------- 414
Cdd:PRK11636 247 PIVANYHAPEIAFSAPYLSEMVRQEMYNrygeNAYED------GYRVYTTITRKVQQAAQQAVRnnvldyDMrhgyrgpa 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 415 ------------------------------------------------------------------------PEDRPENN 422
Cdd:PRK11636 321 nvlwkvgesawdnkkitdtlkalptygpllpavvtsanpqeatamladgssvalpmegvrwarpyrsdtqqgPTPRKVTD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 423 RVGT-------------------------VTIDPDTGAIRAMYGGPDYVAQAQNDATQSRMQAGSIFKTFTLIAALEDGF 477
Cdd:PRK11636 401 VVQTgqqiwvrqvddawwlaqvpdvnsalVSINPQNGAVMALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGL 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 478 PLD--------SRWDGNSPKSfrggWEVNNFNNIDYGRVTLQKATTNSINTAYAEANIEIGPERTRDTAVKLGLPEKTpg 549
Cdd:PRK11636 481 TLAsmlndvpiSRWDAGAGSD----WRPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEYLQRFGFPAQN-- 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 550 LSADASNVLGSASPTVAEMAEVYATIAAGGMHRDSYIVESVTRPDGSSRYEHE--------------SEETRAMD----- 610
Cdd:PRK11636 555 IVHTESLALGSASFTPMQVARGYAVMANGGFLVDPYFISKIENDQGGVIFEAKpkvacpecdipviyGDTQKSNVlendd 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 611 -EEVAI-----NATVAL----QGPPTEGSARS--------------------LRTAMDGRP-----------------VA 643
Cdd:PRK11636 635 vENVATsqeqqNSSVPMpqleQANQALVAQNGaqeyaphvintplafliksaLNTNIFGEPgwmgtgwragrdlkrrdIG 714
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 256561094 644 GKTGTSEKFRSAWFVGFTPQLVTAVGMfqpGEDGSEQTL---SSFGGVQNITGG-------SHPtdIWGDIMSASLEG 711
Cdd:PRK11636 715 GKTGTTNSSKDAWFSGYGPGVVTSVWI---GFDDHRRDLgrtTASGAIKDQISGyeggaksAQP--AWDDYMKAALEG 787
|
|
| PRK14850 |
PRK14850 |
penicillin-binding protein 1b; Provisional |
173-659 |
4.76e-47 |
|
penicillin-binding protein 1b; Provisional
Pssm-ID: 237835 [Multi-domain] Cd Length: 764 Bit Score: 180.04 E-value: 4.76e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 173 RTELPADEIPDSVKQAVVASEDSSFYENRGVSPRGILRAVVNNLRGGDR-QGASTITMQYVERYYTGTETSYVGKAKEAI 251
Cdd:PRK14850 157 RLFIPRNQYPEMLIKTLLAIEDKYFYEHDGIHLSSIGRAFLVNLMSGHTiQGGSTLTQQLVKNLFLTNTRSLWRKINEIY 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 252 MALKIDQEISKDEILSRYLNTIYFGRGA----YGVQEASQAYFGKDAADITDAEAALLVAVIPAPSGYDPANSPKKSVSL 327
Cdd:PRK14850 237 MALILDRFYSKDRILELYLNEVYLGQDGneqiRGFPLASIYYFGRPINELNLDQYALLVGMVKGASLYNPWTNPNLTLKR 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 328 WD---------RVITRQVGEgqmtpeeaDALEFPDTIEPKSeNSLGGTKGYLlaQVRGELVAQGFTDDEINTGGFTIVST 398
Cdd:PRK14850 317 RNlvlfllykqKVITRKLYK--------DLCSRPLNVQSKG-NIISSHPAFI--QLVCEEFHKKIHYPFKNFSGTKIFTT 385
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 399 VDPSIQENTVQAIE-DMPEDRPENN----RVGTVTIDPDTGAIRAMYGGPDYVAQAQNDATQSRMQAGSIFKTFTLIAAL 473
Cdd:PRK14850 386 LDYISQNAAEQAVKiGIPILKRKKRlkdlEVAMVIIDRFSGEVRALIGSSKPEFNGYNRALKARRSIGSLSKPITYLTAL 465
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 474 E--DGFPLDSrWDGNSPKSFRGG----WEVNNFNNIDYGRVTLQKATTNSINTAYAEANIEIGPERTRDTAVKLGLPEKT 547
Cdd:PRK14850 466 SqpEKYHLNT-WISDTPISIKLDngqyWTPKNNNFSFSGKVMLIDALIHSINIPTVHLSINLGLKKLVDSWILLGISSNY 544
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 548 pgLSADASNVLGSASPTVAEMAEVYATIAAGGMHRDSYIVESVTRPDGSSRYEHESEETRAMDEEVAINATVALQGPPTE 627
Cdd:PRK14850 545 --ITPLPSISLGAINLTPMEVAQVFQIIGSGGYKSSLSSIRSIISDDNKVLYQNFPQSKHVESSQASYLTLYAMQQVVKS 622
|
490 500 510
....*....|....*....|....*....|..
gi 256561094 628 GSARSLRTAMDGRPVAGKTGTSEKFRSAWFVG 659
Cdd:PRK14850 623 GTAKSLGTIFKEFSLAGKTGTTNNLVDSWFVG 654
|
|
| FtsI |
COG0768 |
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ... |
360-712 |
1.81e-38 |
|
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain] Cd Length: 568 Bit Score: 151.52 E-value: 1.81e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 360 ENSLGGTKGYLLAQV--RGELVAQGFTDDE-INtgGFTIVSTVDPSIQENTVQAIEDMPEDRpeNNRVGTVT-IDPDTGA 435
Cdd:COG0768 185 EDLLRGTPGKRRVEVdaRGRVIRDLGEEKPpVP--GKDLVLTIDSDLQKIAEEALKKAVEEY--KAKSGAVVvMDPKTGE 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 436 IRAMYGGPDY---------VAQAQNDATQSRMQAGSIFKTFTLIAALEDG-FPLDSRWDGnsPKSFR-GGWEVNNFNNID 504
Cdd:COG0768 261 ILAMASYPSFdpnlfvggpDEPLRNRAVQGTYEPGSTFKPFTAAAALEEGvITPDTTFDC--PGYYRvGGRTIRDWDRGG 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 505 YGRVTLQKATTNSINTAYAEANIEIGPERTRDTAVKLG--------LPEKTPGLSADASNVLGSASPTVA---------- 566
Cdd:COG0768 339 HGTLTLTEALAKSSNVGFYKLALRLGIDKLYDYLKKFGlgqktgidLPGEASGLLPSPKRWYPGETATMSigqglsvtpl 418
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 567 EMAEVYATIAAGGMHRDSYIVESVTRPDGSSRYEHESEETRAMDEEVAinATV--ALQGPPTE--GSARSLRTamDGRPV 642
Cdd:COG0768 419 QLAQAYAAIANGGVLVKPHLVKEIVDPDGEVVKEEPEVLRRVISPETA--ETVreGMEGVVNEpgGTARRAAI--PGYRV 494
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 643 AGKTGTSEKFRS-----------AWFVGFT----PQLVTAVGMFQPGEdgseqtlssfggvqNITGGSHPTDIWGDIMSA 707
Cdd:COG0768 495 AGKTGTAQVVDIgnggyykgrhiASFVGFApadnPRYAVAVVVENPGG--------------GAYGGTVAAPVFREIMEA 560
|
....*
gi 256561094 708 SLEGK 712
Cdd:COG0768 561 YLRLL 565
|
|
| mono_pep_trsgly |
TIGR02070 |
monofunctional biosynthetic peptidoglycan transglycosylase; This family is one of the ... |
177-337 |
4.85e-35 |
|
monofunctional biosynthetic peptidoglycan transglycosylase; This family is one of the transglycosylases involved in the late stages of peptidoglycan biosynthesis. Members tend to be small, about 240 amino acids in length, and consist almost entirely of a domain described by pfam00912 for transglycosylases. Species with this protein will have several other transglycosylases as well. All species with this protein are Proteobacteria that produce murein (peptidoglycan). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273951 [Multi-domain] Cd Length: 224 Bit Score: 132.97 E-value: 4.85e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 177 PADEIPDSVKQAVVASEDSSFYENRGVSPRGILRAVVNNLRGGDR-QGASTITMQYVERYYTGTETSYVGKAKEAIMALK 255
Cdd:TIGR02070 59 PYDQISPNLKRAVIASEDAKFVEHHGFDWEAIQDALEKNEKSGKVvRGGSTISQQLAKNLFLWSGRSYLRKGLEAWATWM 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 256 IDQEISKDEILSRYLNTIYFGRGAYGVQEASQAYFGKDAADITDAEAALLVAVIPAPSGYDpANSPKKSVSLWDRVITRQ 335
Cdd:TIGR02070 139 LETWWSKQRILEVYLNSVEWGNGVFGAEAAARYYFKRSASNLTRGQAARLAAVLPNPKYYD-ENRPGPYVRRKATWILKQ 217
|
..
gi 256561094 336 VG 337
Cdd:TIGR02070 218 MG 219
|
|
| PRK11240 |
PRK11240 |
penicillin-binding protein 1C; Provisional |
109-678 |
1.82e-33 |
|
penicillin-binding protein 1C; Provisional
Pssm-ID: 183049 [Multi-domain] Cd Length: 772 Bit Score: 138.29 E-value: 1.82e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 109 WRWIpslrmivgamALMVLAGLGfAVWLyTDTEVPEPsdFALAQTSRVYYADGETEMGQFSEVN---RTELPADEIPDSV 185
Cdd:PRK11240 9 WLWL----------AAAPLLLFL-ALWL-ADKLWPLP--LHEVNPARVVVAEDGTPLWRFADADgiwRYPVTIEDVSPRY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 186 KQAVVASEDSSFYENRGVSPRGILRAVVNNLRGGD-RQGASTITMQyVERYYTGTETSYVGKAKEAIMALKIDQEISKDE 264
Cdd:PRK11240 75 LEALINYEDRWFWKHPGVNPFSVARAAWQDLTSGRvISGGSTLTMQ-VARLLDPHPRTFGGKIRQLWRALQLEWHLSKRE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 265 ILSRYLNTIYFGRGAYGVQEASQAYFGKDAADITDAEAALLvAVIP-APSGYDPANSPKKSVSLWDRVITRqVGEGQMTP 343
Cdd:PRK11240 154 ILTLYLNRAPFGGTLQGIGAASWAYLGKSPANLSYAEAALL-AVLPqAPSRLRPDRWPERAEAARNKVLER-MAEQGVWS 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 344 EE--ADALEFPDTIEPKSENSLGGtkgyLLAQvrgeLVAQGFTDDEINTggftivsTVDPSIQentvQAIEDMPED---- 417
Cdd:PRK11240 232 AEqvKESREEPVWLAPRQMPQLAP----LFAR----MMLGKSKSDKIVT-------TLDAGLQ----RRLEDLALNwkgr 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 418 RPENNRVGTVTIDPDTGAIRAMYGGPDYVAQAQ---NDATQSRMQAGSIFKTFTLIAALEDGFPLDSRWDGNSPKSFrGG 494
Cdd:PRK11240 293 LPPRSSLAMIVVDHTDMAVRGWVGSVDLNDDSRfghVDMVNAIRSPGSVLKPFVYGLALDDGLIHPASLLQDVPRRT-GD 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 495 WEVNNFNNIDYGRVTLQKATTNSINTAYAEANIEIGPER----TRDTAVKLGLPektPGLSADASNVLGSASPTVAEMAE 570
Cdd:PRK11240 372 YRPGNFDSGFHGPVSMSEALVRSLNLPAVQVLEAYGPKRfaakLRNVGLPLYLP---AGAEPNLSLILGGAGARLEDMVA 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 571 VYATIAAGGMHRDSYIvesvtRPDGSSRyeheseETRAMDEEVA--INATVALQGPPTEGSARSLRTamdgrPVAGKTGT 648
Cdd:PRK11240 449 AYSAFARHGKAAKLRL-----QPDDPLL------ERPLMSPGAAwiIRRIMADEAQPLPDAALPRVV-----PLAWKTGT 512
|
570 580 590
....*....|....*....|....*....|
gi 256561094 649 SEKFRSAWFVGFTPQLVTAVGMFQPgeDGS 678
Cdd:PRK11240 513 SYGYRDAWAIGVNARYVIGIWTGRP--DGT 540
|
|
| PRK13481 |
PRK13481 |
glycosyltransferase; Provisional |
170-316 |
4.98e-33 |
|
glycosyltransferase; Provisional
Pssm-ID: 184078 [Multi-domain] Cd Length: 232 Bit Score: 127.61 E-value: 4.98e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 170 EVNRTELPADEIPDSVKQAVVASEDSSFYENRGVSPRGILRAVVNNLRGGDRQGASTITMQYVERYYTGTETSYVGKAKE 249
Cdd:PRK13481 42 ENKSSFVSADNMPEYVKGAFISMEDERFYKHHGFDLKGTTRALFSTISDRDVQGGSTITQQVVKNYFYDNERSFTRKVKE 121
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 256561094 250 AIMALKIDQEISKDEILSRYLNTIYFGRGAYGVQEASQAYFG----KDAAD---ITDAEAALLVAVIPAPSGYD 316
Cdd:PRK13481 122 LFVAHRVEKQYSKNEILSFYLNNIYFGDNQYTLEGAANHYFGttvnKNSTTmshITVLQSAILASKVNAPSVYN 195
|
|
| Transpeptidase |
pfam00905 |
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ... |
425-663 |
2.29e-27 |
|
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain] Cd Length: 296 Bit Score: 112.89 E-value: 2.29e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 425 GTVTIDPDTGAIRAMYGGPDY-----VAQAQNDATQSRMQAGSIFKTFTLIAALEDG-FPLDSRWDgNSPKSFRGGWEVN 498
Cdd:pfam00905 2 SAVVLDPKTGEVLAMVGKPSYdpngfIGPLRNRAVTSRYEPGSTFKPFTALAALDNGvLKPDETIF-DWPGKQQGGKSIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 499 NFNNIDYGRVTLQKATTNSINTAYAEANIEIGPERTRDTAVKLG--------LPEKTPGLSADASNVLGSASP------T 564
Cdd:pfam00905 81 DWNQDQVGIGTLRQALEYSSNWYMQKLAQKLGADKLRSYLKKFGygnktgigLPGENAGYLTPYWLEGATASFgigltiT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 565 VAEMAEVYATIAAGGMHRDSYIVESVTRPDgSSRYEHEseetRAMDEEVAINATVALQGPPTEGSARSlRTAMDGRPVAG 644
Cdd:pfam00905 161 PLQQAQAYAAIANGGKLVPPHLVKSIEDKV-DPKVLNK----LPISKSTAEKVKDMLRLVVNDGTGTG-TAAVPGYKVAG 234
|
250 260 270
....*....|....*....|....*....|
gi 256561094 645 KTGTSEKF-----------RSAWFVGFTPQ 663
Cdd:pfam00905 235 KTGTAQVAgpkgggyydgaQIGWFVGYAPA 264
|
|
| pbp2_mrdA |
TIGR03423 |
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ... |
355-668 |
5.95e-20 |
|
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain] Cd Length: 592 Bit Score: 94.90 E-value: 5.95e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 355 IEPKSENSLGGTKGYllAQVrgELVAQGFTDDEINT----GGFTIVSTVDPSIQENTVQAIEDmpedrpennRVGT-VTI 429
Cdd:TIGR03423 188 IEKYYEDELRGKPGY--REV--EVNARGRVIRTLSRvppvPGKDLVLTIDARLQQAAEKALGG---------RRGAvVVM 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 430 DPDTGAIRAMYGGPDY--------VAQAQ-------------NDATQSRMQAGSIFKTFTLIAALEDGF--PLDSRWDgn 486
Cdd:TIGR03423 255 DPRTGEILAMVSTPSFdpnlfvdgISSKDykallndpdrpllNRAIQGVYPPGSTFKPVVALAALEEGVitPETRIYC-- 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 487 sPKSFR-GGWEVNNFNNIDYGRVTLQKATTNSINTAYAEANIEIGPERTRDTAVKLGLPEKTP-GLSADASNVLGS---- 560
Cdd:TIGR03423 333 -PGYFQlGGRRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRLGIDKIAEYAKRFGFGQKTGiDLPGEKSGLVPSrewk 411
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 561 ------------------------ASPTvaEMAEVYATIAAGGMHRDSYIVESVTRPDGSS--RYEHESEETRAMDEE-- 612
Cdd:TIGR03423 412 rkrfgqpwypgdtlnvsigqgyvlVTPL--QLAVATAALANGGKLYKPHLVKSIEDPDGGVvrRTEPEVLRPLPISPEnl 489
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256561094 613 -VAINATVA-LQGPptEGSARSLRtAMDGRPVAGKTGTSEKFR------------------SAWFVGFTP----QLVTAV 668
Cdd:TIGR03423 490 dVVREGMRDvVNGP--GGTARRAR-LGLPYKMAGKTGTAQVVSlkqgekydaeqiperlrdHALFVAFAPydnpKIAVAV 566
|
|
| |
