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Conserved domains on  [gi|261280949|gb|ACX62920|]
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conserved hypothetical protein [Paenibacillus sp. Y412MC10]

Protein Classification

ABC transporter permease( domain architecture ID 15349074)

ABC transporter permease is the transmembrane subunit found in a periplasmic binding protein (PBP)-dependent ABC transport system, which may be involved in the transport of one or more from a variety of substrates including sugars, ions, amino acids, and peptides, among others

Gene Ontology:  GO:0043190|GO:0140359|GO:0042626|GO:0016020
PubMed:  25750732|24638992|18535149|17723295
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ABC-2_lan_permease-like cd21809
lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit ...
 10-242 3.24e-76

lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit and similar proteins; This subfamily contains lantibiotic ABC transporter permease subunits which are highly hydrophobic, integral membrane proteins, and part of the bacitracin ABC transport system that confers resistance to the Gram-positive bacteria in which this system operates, particularly to type-A lantibiotics. Lantibiotics are small peptides, produced by Gram-positive bacteria, which are ribosomally-synthesized as pre-peptides and act by disrupting membrane integrity. Genes encoding the lantibiotic ABC transporter subunits are highly organized in operons containing all the genes required for maturation, transport, immunity, and synthesis. For example, in Lactococcus lactis, the lantibiotic nisin is active against other Gram-positive bacteria via various modes of actions; however, its self-protection against the pore-forming nisin is mediated by the ABC transporter composed of NisF, NisE and NisG; the NisG permease subunit transports nisin to the surface and expels it from the membrane. This family includes mostly uncharacterized transport permease subunits that transport lantibiotics to the surface and expel them from the membrane.


:

Pssm-ID: 409634  Cd Length: 235  Bit Score: 230.16  E-value: 3.24e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949  10 AEWLKLSKSKLWPQIFLCAILVMLLGILN-----GKPEELAPWEYLISIMIVLHAMLLLPILTGIFSAMVCRYEHSGGGW 84
Cdd:cd21809    1 AEWLKLKRSKIWLLVLLAPLLAVLLGLLNflrnkDILVKDNPWWSLLTQVVLFYGLLFLPLLIGILASLVCRIEHKNNGW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949  85 KQLLVLPVSRGAVYFAKFSVVAMLLAVVQLLFMGAVLGAGLIHKVDAPIPWEMLLRCLLGGWVACLPLAALQLGVSTAWS 164
Cdd:cd21809   81 KQLLALPVSRTQIYLAKFLVVLLLLALTQLLFLGAIILGGLLLGFGGPIPWLLILKSVLLGWIASLPLIALQLWLSLRFK 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 261280949 165 SFAAPLAlNVVFTIPNMLVANSQTYAPYYPWTQPFLAMMPAGQadFGAFNLPFESLMTVVVGGFLLFFLAGFVYFQRK 242
Cdd:cd21809  161 SFAAPLG-IGILTLPAGLIANSSKLGPFYPWAYPILAMLPGSG--DGAFNVSLELFLIVSLGSFILFLLIGLRHFKRK 235
 
Name Accession Description Interval E-value
ABC-2_lan_permease-like cd21809
lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit ...
 10-242 3.24e-76

lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit and similar proteins; This subfamily contains lantibiotic ABC transporter permease subunits which are highly hydrophobic, integral membrane proteins, and part of the bacitracin ABC transport system that confers resistance to the Gram-positive bacteria in which this system operates, particularly to type-A lantibiotics. Lantibiotics are small peptides, produced by Gram-positive bacteria, which are ribosomally-synthesized as pre-peptides and act by disrupting membrane integrity. Genes encoding the lantibiotic ABC transporter subunits are highly organized in operons containing all the genes required for maturation, transport, immunity, and synthesis. For example, in Lactococcus lactis, the lantibiotic nisin is active against other Gram-positive bacteria via various modes of actions; however, its self-protection against the pore-forming nisin is mediated by the ABC transporter composed of NisF, NisE and NisG; the NisG permease subunit transports nisin to the surface and expels it from the membrane. This family includes mostly uncharacterized transport permease subunits that transport lantibiotics to the surface and expel them from the membrane.


Pssm-ID: 409634  Cd Length: 235  Bit Score: 230.16  E-value: 3.24e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949  10 AEWLKLSKSKLWPQIFLCAILVMLLGILN-----GKPEELAPWEYLISIMIVLHAMLLLPILTGIFSAMVCRYEHSGGGW 84
Cdd:cd21809    1 AEWLKLKRSKIWLLVLLAPLLAVLLGLLNflrnkDILVKDNPWWSLLTQVVLFYGLLFLPLLIGILASLVCRIEHKNNGW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949  85 KQLLVLPVSRGAVYFAKFSVVAMLLAVVQLLFMGAVLGAGLIHKVDAPIPWEMLLRCLLGGWVACLPLAALQLGVSTAWS 164
Cdd:cd21809   81 KQLLALPVSRTQIYLAKFLVVLLLLALTQLLFLGAIILGGLLLGFGGPIPWLLILKSVLLGWIASLPLIALQLWLSLRFK 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 261280949 165 SFAAPLAlNVVFTIPNMLVANSQTYAPYYPWTQPFLAMMPAGQadFGAFNLPFESLMTVVVGGFLLFFLAGFVYFQRK 242
Cdd:cd21809  161 SFAAPLG-IGILTLPAGLIANSSKLGPFYPWAYPILAMLPGSG--DGAFNVSLELFLIVSLGSFILFLLIGLRHFKRK 235
EfiE COG4200
Predicted lantabiotic-exporting membrane pepmease, EfiE/EfiG/ABC2 family [Defense mechanisms];
3-244 5.02e-52

Predicted lantabiotic-exporting membrane pepmease, EfiE/EfiG/ABC2 family [Defense mechanisms];


Pssm-ID: 443354 [Multi-domain]  Cd Length: 250  Bit Score: 168.98  E-value: 5.02e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949   3 SYLRAVSAEWLKLSKSKLWPQIFLCAILVMLLGILN--------GKPEELAPWEYLISIMIVLHAMLLLPILTGIFSAMV 74
Cdd:COG4200    1 MMLRLLRAELLKLKRSLIWLLVLLLPLLSALLGLFNyllnyeilQPYNDGDGWLSLWTQSFLFWSFFFLPLLIALLASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949  75 CRYEHSGGGWKQLLVLPVSRGAVYFAKFSVVAMLLAVVQLLFMGAVLGAGLIHKVDAPIPWEMLLRCLLGGWVACLPLAA 154
Cdd:COG4200   81 ARLEHKNGNWKQLLTLPVSRAKLYLAKLLVVALLLLLSQLLFFVLYLLSGLLLGLSGSIPWGELLKWLLLGWLASLPLIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949 155 LQLGVSTAWSSFAAPLALNVVFTIPN-MLVANSQTYAPYYPWTQPFLAMMPAGQADFgaFNLPFESLMTVVVGGFLLFFL 233
Cdd:COG4200  161 LQLWLSLRFRSFAAPVGIGIVGTIAGlLASVTGSGLGYYYPWSLPVLGMRSNGLGDL--SSVSLVLFLLVSLLYFVLFLI 238

                        250
                 ....*....|.
gi 261280949 234 AGFVYFQRKEV 244
Cdd:COG4200  239 LGILWFKRRDV 249
ABC2_membrane_4 pfam12730
ABC-2 family transporter protein; This family is related to the ABC-2 membrane transporter ...
 7-180 5.45e-29

ABC-2 family transporter protein; This family is related to the ABC-2 membrane transporter family pfam01061.


Pssm-ID: 403819  Cd Length: 179  Bit Score: 107.67  E-value: 5.45e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949    7 AVSAEWLKLSKSKLWPQIFLCAILVMLLGILNGK---PEELAPWEYLISIMIVLHAMLLLPILTGIFSAMVCRYEHSGGG 83
Cdd:pfam12730   1 LIKTEFLKLKRSKIVWIIFLAALLFPFLALLYFNylgKTGIDPAEYYSWSVFGFTLLLLLPIILGIIASYLFFREYDNDT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949   84 WKQLLVLPVSRGAVYFAKFSVVAMLLAVVQLL-FMGAVLGAGLIHKV--DAPIPWEMLLRCLLGGWVACLPLAALqLGVS 160
Cdd:pfam12730  81 LKNLLTIPVSRRKLLFAKLIVLLLLSVLFMLVtFLITVLFGLLSGFVgfSWGLILYLLKKCLEIGLLVFFAVLPI-IALA 159

                         170       180
                  ....*....|....*....|
gi 261280949  161 TAWSSFAAPLALNVVFTIPN 180
Cdd:pfam12730 160 LLFKGYVLPVILTLVYTFAG 179
 
Name Accession Description Interval E-value
ABC-2_lan_permease-like cd21809
lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit ...
 10-242 3.24e-76

lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit and similar proteins; This subfamily contains lantibiotic ABC transporter permease subunits which are highly hydrophobic, integral membrane proteins, and part of the bacitracin ABC transport system that confers resistance to the Gram-positive bacteria in which this system operates, particularly to type-A lantibiotics. Lantibiotics are small peptides, produced by Gram-positive bacteria, which are ribosomally-synthesized as pre-peptides and act by disrupting membrane integrity. Genes encoding the lantibiotic ABC transporter subunits are highly organized in operons containing all the genes required for maturation, transport, immunity, and synthesis. For example, in Lactococcus lactis, the lantibiotic nisin is active against other Gram-positive bacteria via various modes of actions; however, its self-protection against the pore-forming nisin is mediated by the ABC transporter composed of NisF, NisE and NisG; the NisG permease subunit transports nisin to the surface and expels it from the membrane. This family includes mostly uncharacterized transport permease subunits that transport lantibiotics to the surface and expel them from the membrane.


Pssm-ID: 409634  Cd Length: 235  Bit Score: 230.16  E-value: 3.24e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949  10 AEWLKLSKSKLWPQIFLCAILVMLLGILN-----GKPEELAPWEYLISIMIVLHAMLLLPILTGIFSAMVCRYEHSGGGW 84
Cdd:cd21809    1 AEWLKLKRSKIWLLVLLAPLLAVLLGLLNflrnkDILVKDNPWWSLLTQVVLFYGLLFLPLLIGILASLVCRIEHKNNGW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949  85 KQLLVLPVSRGAVYFAKFSVVAMLLAVVQLLFMGAVLGAGLIHKVDAPIPWEMLLRCLLGGWVACLPLAALQLGVSTAWS 164
Cdd:cd21809   81 KQLLALPVSRTQIYLAKFLVVLLLLALTQLLFLGAIILGGLLLGFGGPIPWLLILKSVLLGWIASLPLIALQLWLSLRFK 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 261280949 165 SFAAPLAlNVVFTIPNMLVANSQTYAPYYPWTQPFLAMMPAGQadFGAFNLPFESLMTVVVGGFLLFFLAGFVYFQRK 242
Cdd:cd21809  161 SFAAPLG-IGILTLPAGLIANSSKLGPFYPWAYPILAMLPGSG--DGAFNVSLELFLIVSLGSFILFLLIGLRHFKRK 235
EfiE COG4200
Predicted lantabiotic-exporting membrane pepmease, EfiE/EfiG/ABC2 family [Defense mechanisms];
3-244 5.02e-52

Predicted lantabiotic-exporting membrane pepmease, EfiE/EfiG/ABC2 family [Defense mechanisms];


Pssm-ID: 443354 [Multi-domain]  Cd Length: 250  Bit Score: 168.98  E-value: 5.02e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949   3 SYLRAVSAEWLKLSKSKLWPQIFLCAILVMLLGILN--------GKPEELAPWEYLISIMIVLHAMLLLPILTGIFSAMV 74
Cdd:COG4200    1 MMLRLLRAELLKLKRSLIWLLVLLLPLLSALLGLFNyllnyeilQPYNDGDGWLSLWTQSFLFWSFFFLPLLIALLASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949  75 CRYEHSGGGWKQLLVLPVSRGAVYFAKFSVVAMLLAVVQLLFMGAVLGAGLIHKVDAPIPWEMLLRCLLGGWVACLPLAA 154
Cdd:COG4200   81 ARLEHKNGNWKQLLTLPVSRAKLYLAKLLVVALLLLLSQLLFFVLYLLSGLLLGLSGSIPWGELLKWLLLGWLASLPLIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949 155 LQLGVSTAWSSFAAPLALNVVFTIPN-MLVANSQTYAPYYPWTQPFLAMMPAGQADFgaFNLPFESLMTVVVGGFLLFFL 233
Cdd:COG4200  161 LQLWLSLRFRSFAAPVGIGIVGTIAGlLASVTGSGLGYYYPWSLPVLGMRSNGLGDL--SSVSLVLFLLVSLLYFVLFLI 238

                        250
                 ....*....|.
gi 261280949 234 AGFVYFQRKEV 244
Cdd:COG4200  239 LGILWFKRRDV 249
ABC2_membrane_4 pfam12730
ABC-2 family transporter protein; This family is related to the ABC-2 membrane transporter ...
 7-180 5.45e-29

ABC-2 family transporter protein; This family is related to the ABC-2 membrane transporter family pfam01061.


Pssm-ID: 403819  Cd Length: 179  Bit Score: 107.67  E-value: 5.45e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949    7 AVSAEWLKLSKSKLWPQIFLCAILVMLLGILNGK---PEELAPWEYLISIMIVLHAMLLLPILTGIFSAMVCRYEHSGGG 83
Cdd:pfam12730   1 LIKTEFLKLKRSKIVWIIFLAALLFPFLALLYFNylgKTGIDPAEYYSWSVFGFTLLLLLPIILGIIASYLFFREYDNDT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949   84 WKQLLVLPVSRGAVYFAKFSVVAMLLAVVQLL-FMGAVLGAGLIHKV--DAPIPWEMLLRCLLGGWVACLPLAALqLGVS 160
Cdd:pfam12730  81 LKNLLTIPVSRRKLLFAKLIVLLLLSVLFMLVtFLITVLFGLLSGFVgfSWGLILYLLKKCLEIGLLVFFAVLPI-IALA 159

                         170       180
                  ....*....|....*....|
gi 261280949  161 TAWSSFAAPLALNVVFTIPN 180
Cdd:pfam12730 160 LLFKGYVLPVILTLVYTFAG 179
ABC-2_lan_permease_MutE_EpiE-like cd21807
lantibiotic immunity ABC transporter MutE/EpiE family permease (also called ABC-2 transporter ...
 10-204 1.16e-15

lantibiotic immunity ABC transporter MutE/EpiE family permease (also called ABC-2 transporter MutE/EpiE family permease) subunit; This subfamily includes lantibiotic ABC transporter permease subunits EpiE, MutE, SlvE and NisE, which are highly hydrophobic, integral membrane proteins, and part of the bacitracin ABC transport system that confers resistance to the Gram-positive bacteria in which this system operates, specifically to the lantibiotics mutacin, epidermin, nisin and salivaricin, respectively. Lantibiotics are small peptides, produced by Gram-positive bacteria, which are ribosomally-synthesized as pre-peptides and act by disrupting membrane integrity. Genes encoding the lantibiotic ABC transporter subunits are highly organized in operons containing all the genes required for maturation, transport, immunity, and synthesis. For example, in Staphylococcus epidermidis Tu3298, the lantibiotic epidermin is active against other Gram-positive bacteria via various modes of actions; however, its self-protection against the pore-forming epidermin is mediated by the ABC transporter immunity proteins composed of EpiF, EpiE and EpiG; the EpiE permease subunit transports epidermin to the surface and expels it from the membrane. This subfamily also includes the lantibiotic ABC transporter permease subunits MutE, SlvF, and NisE. Self-protection of the mutacin-producing strain Streptococcus mutans CH43 against the pore-forming lantibiotic mutacin is mediated by an ABC transporter composed of MutF, MutE and MutG. In salivaricin D-producing strain Streptococcus salivarius 5M6c, self-immunity against the intrinsically trypsin-resistant salivaricin is mediated via ABC transporter proteins SlvF, SlvE and SlvG, while in Lactococcus lactis, self-immunity against nisin is mediated by the ABC transporter NisFEG. The MutE, NisE and SlvF permease subunits transport mutacin, nisin and salivaricin, respectively to the surface and expel them from the membrane.


Pssm-ID: 409632  Cd Length: 234  Bit Score: 73.32  E-value: 1.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949  10 AEWLKLSKSKLWPQIFLCAILVMLLGILNGkpeelAPWEYLISIMIVLHAMLLLPILTGIFSAMVCRYEHSGGGWKQLLV 89
Cdd:cd21807    1 AELLKYKRTFTKKLILLAPLITILLALLLG-----GGMNYFQANAYNWWYVLFLPGGIALLCALSIQKEKKAGNYRALLS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949  90 LPVSRGAVYFAKFSVVAMLLAVVQLLFMGAVLGAGLIHKVDAPIPWEMLLRCLLgGWVACLPLAALQLGVSTAWSSFAAp 169
Cdd:cd21807   76 LPVSLKKLWLAKILVLAIYLLLSSLILFVLLLLGGLLLGGGISPPISILLASLL-LWLTSLWQIPLCLFLAKKFGMFVT- 153

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 261280949 170 LALNVVFTIPNMLVANSQTYAPYYPWTQPFLAMMP 204
Cdd:cd21807  154 IIINVLLGLLLGVLLATTSYWWLIPWSWPARLMCP 188
ABC-2_lan_permease_MutG cd21808
lantibiotic immunity ABC transporter MutG family permease (also called ABC-2 transporter MutG ...
 10-241 3.65e-09

lantibiotic immunity ABC transporter MutG family permease (also called ABC-2 transporter MutG family permease) subunit; This subfamily includes lantibiotic ABC transporter permease subunit MutG which is a highly hydrophobic, integral membrane protein, and part of the bacitracin ABC transport system that confers resistance to the Gram-positive bacteria in which this system operates, specifically to lantibiotic mutacin. Lantibiotics are small peptides, produced by Gram-positive bacteria, which are ribosomally-synthesized as pre-peptides and act by disrupting membrane integrity. Genes encoding the lantibiotic ABC transporter subunits are highly organized in operons containing all the genes required for maturation, transport, immunity, and synthesis. For example, in Streptococcus mutans CH43, the lantibiotic mutacin is active against other Gram-positive bacteria via various modes of actions; however, its self-protection against the pore-forming mutacin is mediated by the ABC transporter composed of MutF, MutE, and MutG. This subfamily includes the MutG permease subunit that transports mutacin to the surface and expels it from the membrane.


Pssm-ID: 409633  Cd Length: 237  Bit Score: 55.24  E-value: 3.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949  10 AEWLKLSKSKLWPQIFLCAILVMLLGILNGKpeeLAPWEYLISIMIVLHAM-LLLPILTGIFSAMVCRYEHSGGGWKQLL 88
Cdd:cd21808    1 SEFLKLKRTPLLWIHLLIPILGALLFLAYYS---FSPWSPLSKVSAFFQLLaIAFPLLIGIVCGLVVEQEEEAGNFQNLL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949  89 VLPVSRGAVYFAKFSVVAML-LAVVQLLFMGAVLGAGLIHKVdAPIPWEMLLRCLLGGWVACLPLAALQLGVSTAWSSfA 167
Cdd:cd21808   78 GTPSSRSKAYLSKLLLLLLLgLLSILLAVLIFGIGFKFLLGI-NIIPYGFYLLAALLLFLGSLPLYALHLFLSFRFGK-G 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949 168 APLALNVVFTIpnmLVANSQTYA-----PYYPWTQP-----FLAMMPAGQADFGAFNLPFESLMTVVVGGFLLFFLAGFV 237
Cdd:cd21808  156 ASIGLGIVGSL---IAALMLTGLgdgiwPFIPWAWPvrlssLPLLYLLGAGLSGYLISELITGIIICIILTIILLILSLI 232


                 ....
gi 261280949 238 YFQR 241
Cdd:cd21808  233 WFNR 236
ABC2_membrane_2 pfam12679
ABC-2 family transporter protein; This family is related to the ABC-2 membrane transporter ...
 61-244 1.06e-05

ABC-2 family transporter protein; This family is related to the ABC-2 membrane transporter family.


Pssm-ID: 403774 [Multi-domain]  Cd Length: 281  Bit Score: 45.46  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949   61 LLLPILTGIFSAMVCRYEHSGGGWKQLLVLPVSRGAVYFAKFSVV-AMLLAVVQLLFMGAVLGAGLIHKVDAPIPWEMLL 139
Cdd:pfam12679  76 FLIPVIAALLGADAIAGERERGTIELLLSLPVSRSEILLGKFIGRlAIGLILAVALLAGVLLALAITLALGDPLDLGDLL 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949  140 RCLLGGW--VACLPLAALQLGVSTAWSSF----AAPLALNVVFTIPNMLV-----------ANSQTYAPYYPWTQPFLAM 202
Cdd:pfam12679 156 LLVAASVllALALVFLSIGLLLSSVARSTrtaaAIALGLFFVLAILWPIVlyglaellagpAPPQELLDFLLFLNPTSPY 235

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 261280949  203 MPA----GQADFGAFNLPFESLMTVVVGGFLLFFLAGFVYFQRKEV 244
Cdd:pfam12679 236 NTLlstiLAGSDLSLYGSTATNLLILLAWIAVPLALAYVLFKRKDL 281
ABC-2_lan_permease cd21503
lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit; ...
 10-139 2.50e-03

lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit; This family contains lantibiotic ABC transporter permease subunits which are highly hydrophobic, integral membrane proteins, and part of the bacitracin ABC transport system that confers resistance to the Gram-positive bacteria in which this system operates, particularly to type-A lantibiotics. Lantibiotics are small peptides, produced by Gram-positive bacteria, which are ribosomally-synthesized as pre-peptides and act by disrupting membrane integrity. Genes encoding the lantibiotic ABC transporter subunits are highly organized in operons containing all the genes required for maturation, transport, immunity, and synthesis. For example, in Lactococcus lactis, the lantibiotic nisin is active against other Gram-positive bacteria via various modes of actions; however, its self-protection against the pore-forming nisin is mediated by the ABC transporter composed of NisF, NisE and NisG subunits. This family includes the Lactococcus lactis NisG permease subunit that transports nisin to the surface and expels it from the membrane. This family also includes the lantibiotic ABC transporter permease subunits EpiE, MutE, MutG, and SlvE. Self-protection of the epidermin-producing strain Staphylococcus epidermidis Tu3298 against the pore-forming lantibiotic epidermin is mediated by an ABC transporter composed of the EpiF, EpiE, and EpiG proteins. In the mutacin I-producing strain Streptococcus mutans CH43, self-immunity against mutacin I is mediated by proteins MutF, MutE, and MutG, while in salivaricin D-producing strain Streptococcus salivarius 5M6c, mediation is via ABC transporter proteins SlvF, SlvE, and SlvG.


Pssm-ID: 409631  Cd Length: 221  Bit Score: 38.05  E-value: 2.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949  10 AEWLKLSKSKLWPQIFLCAI---LVMLLGILNGKPEELAPWEYLISIMIVLhamllLPILTGIFSAMVCRYEHSGGGWKQ 86
Cdd:cd21503    1 SEWLKTKRTPFRVLLILFPIlfaLILSLYIGFTNSLKGVSIFSFFTIYNIL-----LPFLISLLIPLLYEQEEQAGNFQN 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 261280949  87 LLVLPVSRGAVYFAKFSVVAMLLAVVQLLFMGAVLGAGLIHKVDAPIPWEMLL 139
Cdd:cd21503   76 ILRSGHSRKKIFLSKFLFITLLLLLVILLLSLPFILIWLITGIGNITIILFLL 128
NosY COG1277
ABC-type transport system involved in multi-copper enzyme maturation, permease component ...
 24-178 5.63e-03

ABC-type transport system involved in multi-copper enzyme maturation, permease component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440888 [Multi-domain]  Cd Length: 201  Bit Score: 36.72  E-value: 5.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261280949  24 IFLCAILVMLLGILNGKPEELAPWEYLISIMIVLHAmLLLPILTGIFSAMVCRYEHSGGGWKQLLVLPVSRGAVYFAKFS 103
Cdd:COG1277   23 ALFLLLALLLAYLGGAASGFLGLGLALLASLFSLLS-LLLPLLAPALGMDAISGERESGTLELLLTLPISRWEIVLGKFL 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 261280949 104 VVAMLLAVVQLLFMGAVLGAGLIHKVDAPIPWEMLLRCLLGGWVACLPLAALQLGVSTAWSS----FAAPLALNVVFTI 178
Cdd:COG1277  102 GALLVLLLALLITFLLALLLGLLLFGSPPPDLGAILGFYLGLLLLGLAFLAIGLFISALTRNqivaAILAIALWLLLVI 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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