|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
31-444 |
0e+00 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 548.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 31 RIRIFYSMFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGL 110
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 111 TNIFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAM 190
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 191 YVPGILCIGMGLVLINRLRDTPqslglppiekykrdphhahhegksasegteeierelstreilftyvltnQWLWFLAAA 270
Cdd:cd17488 161 YVPGIIAILMGIVLCWRLRDRP-------------------------------------------------PYIWLLAFC 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 271 SFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKISKGNRGPMNVLFSLGLLFAILGMWF 350
Cdd:cd17488 192 YVLVYVVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKGNRGPMNLIFALGLLVSVGALWL 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 351 SRSHnQWWVDGTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWGWKGFFIALL 430
Cdd:cd17488 272 VPVH-SYWLLATCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVIS 350
|
410
....*....|....
gi 269302449 431 ACASIALLLFLPTW 444
Cdd:cd17488 351 IAAAISGLLLLPLL 364
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
11-446 |
0e+00 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 530.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 11 PKHIKEIEDQEVVKKKYKYWRIRIFYSMFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGV 90
Cdd:PRK11663 1 PADAPLITDKHEIDARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 91 MSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGG 170
Cdd:PRK11663 81 VSDRSNARYFMGIGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 171 ALIPILTGFIIDYSGWRGAMYVPGILCIGMGLVLINRLRDTPQSLGLPPIEKYKRDPHHAHHEgksaSEGteeieRELST 250
Cdd:PRK11663 161 ALIPLVVGAIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEWRHDALELAQQ----QEG-----AGLSR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 251 REILFTYVLTNQWLWFLAAASFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKISKGNR 330
Cdd:PRK11663 232 KEILTKYVLLNPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFNGNR 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 331 GPMNVLFSLGLLFAILGMWFSRSHNqWWVDGTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFAG 410
Cdd:PRK11663 312 GPMNLIFAAGILLSVGSLWLMPFAS-YVMQAACFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGAALSG 390
|
410 420 430
....*....|....*....|....*....|....*.
gi 269302449 411 YPLGKVTDVWGWKGFFIALLACASIALLLFLPTWNA 446
Cdd:PRK11663 391 YPLAKVLEIWHWTGFFVVISIAAGISALLLLPFLNA 426
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
31-444 |
2.61e-147 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 425.89 E-value: 2.61e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 31 RIRIFYSMFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGL 110
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 111 TNIFFG----MSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSG- 185
Cdd:cd17345 81 INILIGfvpsATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGd 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 186 --WRGAMYVPGILCIGMGLVLINRLRDTPQSLGLPPIEKYKRDPHHAHHEgksasegtEEIERELSTREILFTYVLTNQW 263
Cdd:cd17345 161 gwWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADG--------EEEEQELSAWEIFVKYVLKNKL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 264 LWFLAAASFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKISKGNRGPMNVLFSLGLLF 343
Cdd:cd17345 233 LWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 344 AILGMWFSRSHnqwWVDGTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAY-FGATFAGYPLGKVTDVWGW 422
Cdd:cd17345 313 ALIVYWLAPNV---LVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYlGGSVLATALIGIIVDHFGW 389
|
410 420
....*....|....*....|..
gi 269302449 423 KGFFIALLACASIALLLFLPTW 444
Cdd:cd17345 390 NGGFIVLLASCILAIIFLALVA 411
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
39-426 |
1.98e-129 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 379.41 E-value: 1.98e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 39 FIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMS 118
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 119 SSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYS-GWRGAMYVPGILC 197
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 198 IGMGLVLINRLRDTPQSLGLPPIEKYKRDphhahhegkSASEGTEEIERELSTREILFTYVLTNQWLWFLAAASFFIYIV 277
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEMPNE---------EPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 278 RMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKISKGNRGPMNVLFSLGLLFAILGMWFSRSHNQW 357
Cdd:TIGR00881 232 RTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPL 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 269302449 358 WvDGTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWGWKGFF 426
Cdd:TIGR00881 312 M-DLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
31-444 |
3.13e-125 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 368.14 E-value: 3.13e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 31 RIRIFYSMFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGL 110
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 111 TNIFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAM 190
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 191 YVPGILCIGMGLVLINRLRDTPqslglppiekykrdPHhahhegksasegteeierelstreilftyvltnqwLWFLAAA 270
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSP--------------PY-----------------------------------VWVLSLA 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 271 SFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKISKGNRGPMNVLFSLGLLFAILGMWF 350
Cdd:cd17312 192 YAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWF 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 351 SRSHnqWWVDGTLLFVIGFFLYGPQMMIGLAAAELSHKK-AAGTASGFTGWFAYFGATFAGYPLGKVTDVWGWKGFFIAL 429
Cdd:cd17312 272 FPHN--KLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKeAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFL 349
|
410
....*....|....*
gi 269302449 430 LACASIALLLFLPTW 444
Cdd:cd17312 350 ISAALLSVLLLLSLW 364
|
|
| glpT |
TIGR00712 |
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted ... |
8-449 |
3.16e-123 |
|
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted to span the membrane at least 8 times. The two members confirmed experimentally as glycerol-3-phosphate transporters, from E. coli and B. subtilis, share more than 50 % amino acid identity. Proteins of the hexose phosphate and phosphoglycerate transport systems are also quite similar. [Transport and binding proteins, Other]
Pssm-ID: 129795 [Multi-domain] Cd Length: 438 Bit Score: 365.70 E-value: 3.16e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 8 FQPPKHIKEIEDQEVvKKKYKYWRIRIFYSMFIGYIFYYFTRKSFTFAMPTLIaDLGFDKAQLGIIGSTLYFSYGISKFV 87
Cdd:TIGR00712 3 FKPAPHIARLPAAKI-DPTYKRLRWQVFLGIFFGYAAYYLVRKNFALAMPYLV-EQGFSKGELGFALSAISIAYGFSKFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 88 SGVMSDQSNPRYFMAIGLMITGLTNIFFGM----SSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWS 163
Cdd:TIGR00712 81 MGSVSDRSNPRVFLPAGLILSAAVMLLMGFvpwaTSSIAIMFVLLFLNGWFQGMGWPPCGRTMVHWWSQSERGTIVSIWN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 164 TSHNIGGALIPILTGFIID-YSGWRGAMYVPGILCIGMGLVLINRLRDTPQSLGLPPIEKYKRD-PHHAHhegksasegt 241
Cdd:TIGR00712 161 CAHNIGGGIPPLLVLLGMAwFNDWHAALYFPAICAIIVALFAFAMMRDTPQSCGLPPIEEYRNDyPDDYN---------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 242 EEIERELSTREILFTYVLTNQWLWFLAAASFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWL 321
Cdd:TIGR00712 231 EKAEQELTAKEIFMQYVLPNKLLWYIAIANVFVYLLRYGVLDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWM 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 322 SDKISKGNRGPMNVLFSLGLLFAILGMWFSRSHNQwWVDGTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWF 401
Cdd:TIGR00712 311 SDKVFKGNRGATGVFFMTLVTIAVIVYWMNPAGNP-LVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLF 389
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 269302449 402 AYFGAT-FAGYPLGKVTDVWGWKGFFIALLACASIALLLFLPTWNATEK 449
Cdd:TIGR00712 390 GYLGGSvAASAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKR 438
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
7-455 |
1.13e-119 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 357.10 E-value: 1.13e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 7 FFQPPKHIKEIEDQEVvKKKYKYWRIRIFYSMFIGYIFYYFTRKSFTFAMPTLIaDLGFDKAQLGIIGSTLYFSYGISKF 86
Cdd:PRK11273 4 IFKPAPHKARLPAAEI-DPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLV-EQGFSRGDLGFALSGISIAYGFSKF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 87 VSGVMSDQSNPRYFMAIGLMITGLTNIFFGM-----SSSIVLFALWWgLNGWFQGWGWPPCARLLTHWYAKSERGTWWSV 161
Cdd:PRK11273 82 IMGSVSDRSNPRVFLPAGLILAAAVMLFMGFvpwatSSIAVMFVLLF-LCGWFQGMGWPPCGRTMVHWWSQKERGGIVSV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 162 WSTSHNIGGALIPILtgFIID---YSGWRGAMYVPGILCIGMGLVLINRLRDTPQSLGLPPIEKYKRDphhahhegkSAS 238
Cdd:PRK11273 161 WNCAHNVGGGLPPLL--FLLGmawFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEEYKND---------YPD 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 239 EGTEEIERELSTREILFTYVLTNQWLWFLAAASFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVA 318
Cdd:PRK11273 230 DYNEKHEQELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLC 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 319 GWLSDKISKGNRGPMNVLFSLGLLFAILGMWFSRSHNQwWVDGTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFT 398
Cdd:PRK11273 310 GWMSDKVFRGNRGATGVFFMTLVTIATIVYWLNPAGNP-TVDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFT 388
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 269302449 399 GWFAYFGATFAGYP-LGKVTDVWGWKGFFIALLACASIALLLFLPTWNATEKNTRSKA 455
Cdd:PRK11273 389 GLFGYLGGSVAASAiVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKRHHEELL 446
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
31-441 |
3.65e-102 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 310.81 E-value: 3.65e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 31 RIRIFYSMFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGL 110
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 111 TNIFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAM 190
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 191 YVPGILCIGMGLVLINRLRDTPQSLGLPPIEKykrdphhAHHEGKSASEGTEeierelstrEILFTYVLTNQWLWFLAAA 270
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEPSDVGLNNIEE-------EESKGKKKKSPRG---------ESTLKELLLSPFLWLLSLG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 271 SFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDK-------ISKGN-RGPMNVLFSLGL- 341
Cdd:cd17343 225 YLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWavakhgsSSRGNpRMPLALVFMAGLt 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 342 -LFAILGMWFSRSHNQWWVDgTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVW 420
Cdd:cd17343 305 vSLHLFRVHITSDSSELFIL-LLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHY 383
|
410 420
....*....|....*....|..
gi 269302449 421 GWKG-FFIALLACASIALLLFL 441
Cdd:cd17343 384 DWRTaFLLLEILCAITVVILFL 405
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
24-449 |
6.85e-77 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 244.01 E-value: 6.85e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 24 KKKYKYWRIRIFYSMFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAI 103
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 104 GLMITGLTNIFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDY 183
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 184 SGWRGAMYVPGILCIGMGLVlinrlrdtpqslglppiekykrdphhahhegksasegteeierelstreilftyvltnqW 263
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL-----------------------------------------------------------R 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 264 LWFLAAASFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKISKGNRGPMnvlfSLGLLF 343
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL----AIGLLL 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 344 AILGMWFSRSHNQWWVDGTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWGWK 423
Cdd:COG2271 258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
410 420
....*....|....*....|....*.
gi 269302449 424 GFFIALLACASIALLLFLPTWNATEK 449
Cdd:COG2271 338 AAFLLLAALALLAALLALLLLRETRK 363
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
32-453 |
4.30e-72 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 234.94 E-value: 4.30e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 32 IRIFYSMFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLT 111
Cdd:PRK09556 28 MQSYLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAIC 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 112 NIFFGMS-----SSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDY--S 184
Cdd:PRK09556 108 MLGFGASlgsgsVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYffD 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 185 GWRGAMYV-PGILCIGMGLVLINRLRDTPQSLGLPPIEKYKRDPhhahhegkSASEGTEEIERELSTREILFTYVLTNQW 263
Cdd:PRK09556 188 GHVIGMFIfPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEP--------ISEEDKETESTDMTKWQIFVEYVLKNPV 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 264 LWFLAAASFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDkISKGNRGpMNVLFSLGLLF 343
Cdd:PRK09556 260 IWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSD-LANGRRA-LVACIALALII 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 344 AILgMWFSRSHNQWWVDGTlLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAY-FGATFAGYPLGKVTDVW-- 420
Cdd:PRK09556 338 FTL-GVYQHATSEYMYLAS-LFALGFLVFGPQLLIGVAAVGFVPKKAIGVANGIKGTFAYlFGDSFAKVGLGMIADPTkn 415
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 269302449 421 ----------GWKGFFIALLACASIALLLFLPTWNATEKNTRS 453
Cdd:PRK09556 416 gtpifgytltGWAGTFAALDIAAIGCICLMAIVAVMEERKIRR 458
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
38-409 |
6.57e-39 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 143.71 E-value: 6.57e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 38 MFIGYIFYYFTRKSFTFAMPTLIA-DLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFG 116
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 117 MSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMYVPGIL 196
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 197 CIGMGLVLInrlrdtpqslglppiekYKRDPHhahhegksASEGTEEIERELSTREILFTYVLTNQWLWFLAAAsFFIYI 276
Cdd:pfam07690 161 SLLAAVLLL-----------------LPRPPP--------ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 277 VRMAVNDWSALFlIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKIskGNRGPMNVLFSLGLLFAILGMWFSRSHNQ 356
Cdd:pfam07690 215 AFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL--GRRRRLLLALLLLILAALGLLLLSLTLSS 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 269302449 357 WWVdGTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFA 409
Cdd:pfam07690 292 LWL-LLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
31-441 |
2.12e-37 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 140.01 E-value: 2.12e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 31 RIRIFYSMFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGL 110
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 111 TNIFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAM 190
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 191 YVPGILCIGMGLVLINRLRDtpqslglppiekykrdphhahhegksasegteeierelstreilftyvltnqwLWFLAAA 270
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYLRQ-----------------------------------------------------VWGLALG 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 271 SFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKISKGNRGPMNVLFSLGLLFAILGMWF 350
Cdd:cd17319 188 YFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 351 SRSHnqwWVDGTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWG-WKGFFIAL 429
Cdd:cd17319 268 TTSP---VVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFL 344
|
410
....*....|..
gi 269302449 430 LACASIALLLFL 441
Cdd:cd17319 345 AAVALLAALLVL 356
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
28-407 |
1.93e-35 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 134.33 E-value: 1.93e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 28 KYWRIRIFYSMFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMI 107
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 108 TGLTNIFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWR 187
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 188 GAMYVPGILCIGMGLVLINRLRDTPqslglppiekykrdPHHAHHEGKSASEgteeierelstreilftyVLTNQWLWFL 267
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPESR--------------PAARARLRGSLRE------------------LLRRPRLLLL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 268 AAASFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKISKGNrgpmnvLFSLGLLFAILG 347
Cdd:COG2814 213 LLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR------LLLIGLLLLALG 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 348 MWFSRSHNQWWVDGTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGAT 407
Cdd:COG2814 287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
38-441 |
3.75e-35 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 134.48 E-value: 3.75e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 38 MFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGM 117
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 118 SSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDY--SGWRGAMYVPGI 195
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 196 LCIGMGLVLINRLRDTPQSLGLPPIEKykrdphhahhegksasegteeierELSTREILFTYVLTNQWLWFLAAASFFIY 275
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEA------------------------SSKSVLKLLKRVLKNPGLWLLLLAIFLVN 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 276 IVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKISKgnRGPMNVLFSLGLLFAILGMWFSRSHN 355
Cdd:cd06174 217 LAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG--RKPLLLIGLLLMALGLALLLLAPSLL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 356 QWWVdgtLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTD-VWGWKGFFIALLACAS 434
Cdd:cd06174 295 LLLL---LLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLL 371
|
....*..
gi 269302449 435 IALLLFL 441
Cdd:cd06174 372 LAAILLL 378
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
38-441 |
4.15e-35 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 134.29 E-value: 4.15e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 38 MFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGM 117
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 118 SSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMYVPGILC 197
Cdd:cd17475 81 VGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 198 IGMGLVLINRLRDTPQSlglppiekyKRDPHHAHHEGKSASEgteeierelstreilftyVLTNQWLWFLAAASFFIYIV 277
Cdd:cd17475 161 ILAAVLFWLFYREPPAA---------SAATESASTLLRSLKE------------------VLRNRDVWLIAIAGALLVAP 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 278 RMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKISKGNRGPmnVLFSLGLL--FAILGMWFSRSHN 355
Cdd:cd17475 214 QFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRP--VLVITAAIaaAALLVLSLLSPGT 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 356 QWWVDGTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGAtFAGYPL--GKVTDVWGWKGFFIALLACA 433
Cdd:cd17475 292 PLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGI-AIGPPLfgLLVDATHSYAPAWLALALLL 370
|
....*...
gi 269302449 434 SIALLLFL 441
Cdd:cd17475 371 VLAALLLL 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
31-441 |
2.58e-31 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 123.84 E-value: 2.58e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 31 RIRIFYSMFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGL 110
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 111 TNIFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAM 190
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 191 YVPGILCIGMGLVLINRLRDTPqslglppiekykrdphhahhegksASEGTEEIERELSTREILFTYvlTNQWLWFLAAA 270
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPP------------------------AGAAAAAKASLRDQLEALRDP--RFWLLSLLYFG 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 271 SFFIYIvrmAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKIskgnrGPMNVLFSLGLLFAILGMWF 350
Cdd:COG2223 217 TFGSFI---GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI-----GGRRVLLIVFALMALGLLLL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 351 SRSHNQWWVDGTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWG-WKGFFIAL 429
Cdd:COG2223 289 ALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVF 368
|
410
....*....|..
gi 269302449 430 LACASIALLLFL 441
Cdd:COG2223 369 AVLALVALVLTL 380
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
31-444 |
1.94e-25 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 107.40 E-value: 1.94e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 31 RIRIFYSMFIGYIFYYFTRKSFTFAMPTLIADLG--------------------FDKAQ-----LGIIGSTLYFSYGISK 85
Cdd:cd17342 1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEWTpsnsntsielheetwnanplFPSQDdaalfLGVLDTIFLFSYAIGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 86 FVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSS------SIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWW 159
Cdd:cd17342 81 FISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTewlhfyNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 160 SVWSTSHNIGGALIPILTGFIIDYsGWRGAMYVPGILCIGMGLVLINRLRDTPQSlglppiekykrdphhahhegksase 239
Cdd:cd17342 161 GLWSACASVGNIIGALLASSVLDY-GYEYAFLVTSSLLFAGAIVVFFGLLSSPPG------------------------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 240 gteeierelstreiLFTYVLTNQWLWFLAAASFFiyivrmavndWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAG 319
Cdd:cd17342 215 --------------VIPYSLAYACLKLVNYSFFF----------WLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAG 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 320 WLSDKISKgnRGPMNVLFslgLLFAILGMWF-SRSHNQWWVDGTLLFVIGFFLYGPQMMIGLA-AAEL-------SHKKA 390
Cdd:cd17342 271 YISDRMGS--RSPVVVVM---LLLAIPSLFVySHSPSDKVLNAFVMTITGFFIGGPANLISSAiSADLgrqpqlrGSSEA 345
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 269302449 391 AGTASGFTGWFAYFGATFAGYPLGKVTDVWGWKGFFIALLACASIALLLFLPTW 444
Cdd:cd17342 346 LATVTGIIDGTGSIGAAIGQVLVPLIQNRLGWMWVFYFFIIMTILTIVCILPLL 399
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
56-444 |
1.97e-22 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 98.01 E-value: 1.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 56 MPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSS---IVLFALWWGL-N 131
Cdd:cd17478 19 LPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNywlLLLLVALAGIgS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 132 GWFQgwgwPPCARLLTHwYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMYVPGILCIGMGLVLInrlrdt 211
Cdd:cd17478 99 AAFH----PEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLL------ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 212 pqslglppieKYKRDPHHAHHEGKSASEGTEeierelstreilfTYVLTNQWLWFLAAASFFIYIVRMAVNDWSALFLIE 291
Cdd:cd17478 168 ----------RLRPLKKPEAKKAAAKSSARS-------------TLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 292 tKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKIskgNRGPMNVLFSLGLLFAILGMWFSRSHNQWwvdgTLLFVIGFFL 371
Cdd:cd17478 225 -RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRF---GRRRVIIASLLLAAPFLLLFLLTPGIWSY----ILLVLAGFLL 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 269302449 372 YGPQMMIGLAAAELSHKKaAGTASGFTGWFAYFGATFAGYPLGKVTDVWgwkGFFIALLACASIALLLFLPTW 444
Cdd:cd17478 297 FASFPVTVVLAQELLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAF---GLESVLLILALLPLLGALLAF 365
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
31-441 |
1.34e-21 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 96.08 E-value: 1.34e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 31 RIRIFYSMFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGL 110
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 111 TNIFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSER------GTWWSvwstshnIGGALIPILTGFIIDYS 184
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAsrlnllHAFFS-------LGALLGPLLGGLLILLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 185 ---GWRGAMYVPGILCIGMGLVLINRlrdtpqslGLPPIEKYKRDPHHAHHEGKSasegteeierelstreilftyVLTN 261
Cdd:COG0738 159 lslSWHLPYLILAVLLLLLALLFLRS--------KLPEIEEEEEEAAGSAASLKS---------------------LLKN 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 262 QWLWFLAAASFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKISkgnRGPMNVLFSLGL 341
Cdd:COG0738 210 PRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFG---PVRLLRLSALLA 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 342 LFAILGMWFSrshNQWWVDGTLLFVIGFFLyGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWG 421
Cdd:COG0738 287 AVGLLLALLA---PGPWLALIGLALVGLGL-SLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG 362
|
410 420
....*....|....*....|
gi 269302449 422 WKGFFIALLACASIALLLFL 441
Cdd:COG0738 363 LRAAFLVPLVCYLLILLLAL 382
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
31-439 |
1.61e-21 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 95.85 E-value: 1.61e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 31 RIRIFYSMFIGYIFYYFTRK-------------SFTFAMPTLIADLG-------FD----KAQLGIIGSTLYFSYGISKF 86
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKpisivksvlhpncSALIPPPNIVLNNTtwcgwapFDgkngTELLGALDSAFLFAYAIGMF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 87 VSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWW-----GLNGWFQGWGWPPCARLLTHWYAKSERGTWWSV 161
Cdd:cd17344 81 FSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHSLWYfvvvqILAGLFQSTGWPSVVACVGNWFGKGKRGLIMGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 162 WStSH----NIGGALIPiltGFIIDySGWRGAMYVPGILCIGMGLVLINRLRDTPQSLglppiekykrdphhahhegksa 237
Cdd:cd17344 161 WN-SHtsvgNILGSLIA---GIFVS-SAWGLSFIVPGIIIAAMGVLVFLFLVEHPPGV---------------------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 238 segteeierelstreILFTYVLtnqwlwflaaasFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLV 317
Cdd:cd17344 214 ---------------IEFSLCL------------FFAKLVSYTFLYWLPLYISNTAILSAKKAGDLSTLFDVGGIVGGIL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 318 AGWLSDKIskGNRGPMNVLFsLGLLFAILGMWFSRSHNQWWVDGTLLFVIGFFLYGPQMMIGLA-AAEL-SHKKAAGTAS 395
Cdd:cd17344 267 AGYISDYT--GGRATTCAAM-LILAAPMLFIYNYFGQVSMTTNIVLLIVCGLLVNGPYALITTAvSADLgTHKSLKGNAR 343
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 269302449 396 GF---------TGWF-AYFGATFAGYplgkvTDVWGWKGFFIALLACASIALLL 439
Cdd:cd17344 344 ALatvtaiidgTGSIgAALGPLLAGL-----ISSRGWNNVFYMLIAADVCAGLL 392
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
56-441 |
5.10e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 91.10 E-value: 5.10e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 56 MPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGWFQ 135
Cdd:cd17325 19 LPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLAS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 136 GWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMYVPGIL-CIGMGLVLInrlrdtpqs 214
Cdd:cd17325 99 AAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALaLLALVLALL--------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 215 lglppiekYKRDPHHAHHEGKSASEGTEEIERELstreilftyvLTNQWLWFLAAASFFIYIVRMAVNDWSALFLIETKH 294
Cdd:cd17325 170 --------LLPEPRPPPNKRAVSAARLRSGLRLL----------LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 295 YAAVKANFCVSLFEIGGLFGMLVAGWLSDKISKgnrgpmNVLFSLGLLFAILGMWFSRSHNQWWVDGTLLFVIGFFLYGP 374
Cdd:cd17325 232 LSPAQIGLLFGAQGLASALSQPPAGKLSDRIGR------KPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 269302449 375 QMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWGWKGFFIALLACASIALLLFL 441
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
56-446 |
1.20e-17 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 84.54 E-value: 1.20e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 56 MPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGWFQ 135
Cdd:COG2807 41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 136 GWGWPPCARLLTHWYAKSeRGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMYVPGILCIGMGLVLINRLRDTPqsl 215
Cdd:COG2807 121 AVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRP--- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 216 glppiekykRDPHHAHHEGKSASegteeierelstreilftyVLTNQWLWFLAAASFFIYIVRMAVNDWSALFLIEtKHY 295
Cdd:COG2807 197 ---------AAAAAAPAAASLRS-------------------LWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 296 AAVKANFCVSLFEIGGLFGMLVAGWLSDKIskGNRGPMNVLFSLGLLFAILGMWFSRSHNQW-WVdgtllFVIGFFLYG- 373
Cdd:COG2807 248 SAATAGLLLSLFQLAGIPGSLLVPLLADRL--GDRRPLLLLLGLLGLAGLLGLLLAPGSLPWlWA-----VLLGLGQGGl 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 269302449 374 PQMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWGwkGFFIALLACASIALLLFLPTWNA 446
Cdd:COG2807 321 FPLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATG--SWTAALLLLAALAVLMLVAGLLA 391
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
54-396 |
7.80e-17 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 82.02 E-value: 7.80e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 54 FAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGW 133
Cdd:TIGR00895 38 FAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 134 FQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMYVPGILCIGMGLVLINRLRDTPQ 213
Cdd:TIGR00895 118 GLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESID 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 214 SLGLPPIEKYKR-----DPHHAHHEGKSASEGTEEIERELSTREILFTYVLTNQWLWFLAAASFFIYIVRMAVNdWSALF 288
Cdd:TIGR00895 198 FLVSKRPETVRRivnaiAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTARITVLLWLLYFMLLVGVYFLTN-WLPKL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 289 LIETKhYAAVKANFCVSLFEIGGLFGMLVAGWLSDKIskgNRGPMNVLFSLGLLFAILGMWFSRSHNqwwVDGTLLFVIG 368
Cdd:TIGR00895 277 MVELG-FSLSLAATGGALFNFGGVIGSIIFGWLADRL---GPRVTALLLLLGAVFAVLVGSTLFSPT---LLLLLGAIAG 349
|
330 340
....*....|....*....|....*...
gi 269302449 369 FFLYGPQMMIGLAAAELSHKKAAGTASG 396
Cdd:TIGR00895 350 FFVNGGQSGLYALMALFYPTAIRATGVG 377
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
54-441 |
9.94e-17 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 81.09 E-value: 9.94e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 54 FAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGW 133
Cdd:cd17365 20 FVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 134 FQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMYVpgilcigmglvlinrlrdtpq 213
Cdd:cd17365 100 GLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL--------------------- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 214 sLGLPPIekykrdphhahhegksasegteeierelstreILFTYVLTNQWLWflaAASFFIYIVRMAVNDWSALFLIETK 293
Cdd:cd17365 159 -GGVPPL--------------------------------ILLPLLRGTLLLW---VTFFMGLLLVYLLNSWLPKLMVEAG 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 294 hYAAVKANFCVSLFEIGGLFGMLVAGWLSDKiskgnRGPMNVLFSLGLLFAILGMWFSRSHNQWWVDGTLLFVIGFFLYG 373
Cdd:cd17365 203 -YSLSQALTITLLLNIGGVIGSLLLGWLADR-----FGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNG 276
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 269302449 374 PQMMIGLAAAELSHKKAAGTASGFTGWFAYFGAtFAGYPLGKVTDVWGWkGFFIALLACASIALLLFL 441
Cdd:cd17365 277 AQVGLYALAARFYPTEVRATGVGWALGVGRLGA-ILGPLLGGLLLAAGL-GPESVFLALAIPAALGAL 342
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
56-441 |
1.01e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 78.36 E-value: 1.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 56 MPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGWFQ 135
Cdd:cd17324 22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 136 GWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMYVPGILCIGMGLVLINRLRDTPQSL 215
Cdd:cd17324 102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 216 GLPPIEKYkrdphhahhegksasegteEIERELSTREILFTYVLTnqWLWFLAAASFFIYIvrmavndwsALFLIETKHY 295
Cdd:cd17324 182 PGSLGLLS-------------------SLLLLLRNPRLRLAYLIT--FLLFGGFFALYTYL---------APFLTDVPGF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 296 AAVKANFCVSLFEIGGLFGMLVAGWLSDkiskgnRGPMNVLFSLGLLFAILGMWFSRSHNQWWVDGTLLFVIGFFLYGPQ 375
Cdd:cd17324 232 SSSAIIGLLLLFGVAGVVGSPLAGRLAD------RGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAH 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 269302449 376 MMIGLAAAELSHkKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWGWKGFFIALLACASIALLLFL 441
Cdd:cd17324 306 SALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
34-441 |
2.58e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 74.17 E-value: 2.58e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 34 IFYSMFIGYIFYYFtrksFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNI 113
Cdd:cd17489 1 ILLANFFFFLSFYL----LLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 114 FFGMSSSIVLFALWWGLNGWfqGWGW-PPCARLLTHWYAKSER-GTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMY 191
Cdd:cd17489 77 LYLLATSVALLLVLRLIHGI--GWGAfTTAAATLVADIIPPSRrGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 192 VPGILCIgMGLVLINRLRDTPQSlgLPPIEKYKRDPHHAHHEGKsasegteeierelstreilftyvltnqwLWFLAAAS 271
Cdd:cd17489 155 VAAVLAL-LALLLVFLVKDPPPV--AAEEAEAGTRAFRRLVEKK----------------------------VLPPALIL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 272 FFIYIVRMAVNDWSALFLIETkhyAAVKANFCVSLFEIGGLFGMLVAGWLSDkiskgnRGPMNVLFSLGLLFAILGMWFs 351
Cdd:cd17489 204 FLASIAYGAISTFLPLYAAER---GISNAGLFFTVYAIALLLSRPFSGKLSD------RKGPKTVIIPGLLLLALGLLL- 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 352 rshnQWWVDGTLLFVIGFFLYG-----PQMMIGLAAAELSHKKAAGTASGFtgWFAYF--GATFAGYPLGKVTDVWGWKG 424
Cdd:cd17489 274 ----LSFAGSPWMLLLAAVLYGlgfglLFPALQALAVDLVPPHRRGAANGT--FFIFFdlGIGLGGLLLGLVAELFGYRA 347
|
410
....*....|....*..
gi 269302449 425 FFIALLACASIALLLFL 441
Cdd:cd17489 348 MFLLAAVVVLLALVLYI 364
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
31-290 |
7.91e-14 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 71.77 E-value: 7.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 31 RIRIFYSMFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGL 110
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 111 TNIFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAM 190
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 191 YVPGILCIgMGLVLINRLRDTPQSLGLPPIEKYKRDPHHAHHEGKSASEGTEEIERELSTREILFTYVLTNQWLWFLAAA 270
Cdd:COG0477 172 LINAPLGL-LALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLAL 250
|
250 260
....*....|....*....|
gi 269302449 271 SFFIYIVRMAVNDWSALFLI 290
Cdd:COG0477 251 LLLLALLLLAALLLLLLLLL 270
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
35-441 |
9.76e-14 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 72.25 E-value: 9.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 35 FYSMFIGYIFYYFTRKSFTFAMPTLIA--DLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTN 112
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 113 IFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIG----GALIPILTGFIIDYSGWRG 188
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGallaALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 189 AMYVPGILCIgmgLVLINRLRdtpqslglppiekykrdphhahhegksasegteeierelstreilftyvltnqwLWFLA 268
Cdd:cd17316 161 LFLIGALPAL---LALLLRRR------------------------------------------------------TLLLI 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 269 AASFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKIskgNRGPMNVLFSLGLLFAILGM 348
Cdd:cd17316 184 LLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI---GRKKTLVIGLILSGILALPL 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 349 WFSRSHNQWWVdGTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWGWKGFFIA 428
Cdd:cd17316 261 FYLLSGSPTLL-LLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPAL 339
|
410
....*....|...
gi 269302449 429 LLACASIALLLFL 441
Cdd:cd17316 340 ILALLAIVALIVA 352
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
35-443 |
4.19e-12 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 67.33 E-value: 4.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 35 FYSMFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDqsnpRYFMAIGLMITGLTNIF 114
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILAD----RFGRVRVLVITILLFAV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 115 FGMSSSIVlfALWWGLNGW--FQGWG----WPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYS---- 184
Cdd:cd17371 77 FTLLCGFA--QNYWQLLILraLAGLGfggeWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLppei 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 185 GWRGAMYVpGILCIGMGLVLINRLRDTPQSlglppiekykrdphhAHHEGKSASEGTEEIERELSTREILFTYVLTNqwl 264
Cdd:cd17371 155 AWRVLFLL-GALPALLVLFIRRFVKEPPQW---------------QAARAARRHFADRPSLRELFSPPLLRTTLLAS--- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 265 wFLAAASFFIYivrMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKISkgnRGPMNVLFSLG-LLF 343
Cdd:cd17371 216 -LLATGALGGY---YGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIG---RRNNFALFALGsAIS 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 344 AILGMWFSRSHNQWWVdgtLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWGWK 423
Cdd:cd17371 289 ILLYFFLPLSPTLILI---LGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLG 365
|
410 420
....*....|....*....|...
gi 269302449 424 ---GFFIALLACASIALLLFLPT 443
Cdd:cd17371 366 taiAVFAAVYYIAGLVLALLLPE 388
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
55-409 |
9.47e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 66.04 E-value: 9.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 55 AMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGwF 134
Cdd:cd17321 18 ALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQG-I 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 135 QGWGWPPCA-RLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMYVPGILCIgMGLVLINRLRDTpq 213
Cdd:cd17321 97 GAAAIMPASlALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL-VALLLARTFSGA-- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 214 slglppiekykrdphhahhegksasegteeierelstreilftyvltnqwlwflAAASFFIYIVRMAVNDWSALFLIETK 293
Cdd:cd17321 174 ------------------------------------------------------VLAAFLLGAALGGLLFLLPLYLQGVL 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 294 HYAAVKANFCVSLFEIGGLFGMLVAGWLSDKIskGNRGPMnvlfSLGLLFAILGMW---FSRSHNQWWVDGTLLFVIGF- 369
Cdd:cd17321 200 GYSPLQAGLALLPLALAMLVAAPLAGRLADRF--GPRLVL----VAGLLLTAVGLLllaLLGADSSVWLLLPGLVLLGLg 273
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 269302449 370 --FLYGPQMMIGLAAAElshKKAAGTASGFTGWFAYFGATFA 409
Cdd:cd17321 274 lgLFATPLTNAALSSVP---KEKAGAASGILNTARQLGGALG 312
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
49-443 |
1.91e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 65.37 E-value: 1.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 49 RKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWW 128
Cdd:cd17355 19 RYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 129 GL--NGWFQGWGWPPCARLLTHWYAKsERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMYVPGILCIGMGLVLIN 206
Cdd:cd17355 99 GLlgGGGAGTLAAVAFATVAAWWFER-RRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 207 RLRDTPQSLGLPPiekykRDPHHAHHEGKSASEGteeierelstreilftyvLTNQWLWFLAAASFF--IYIVRMAVNDW 284
Cdd:cd17355 178 LLRRRPADLALRA-----YDDASPASPGSTLKEA------------------LRSASFWLLALAFFLcgFAVVGLIVHLV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 285 SALfliETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKISkgnRGPMNVLFSLGLLFAILGMWFSRSHNQWWvdgtLL 364
Cdd:cd17355 235 PYL---ADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYS---PRRLLAASYALRALGLALLLLLPFPPLAL----LL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 365 FVIGF-FLYGPQM-MIGLAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWG-WKGFFIALLACASIALLLFL 441
Cdd:cd17355 305 FAALFgLGWGATVpLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALLVL 384
|
..
gi 269302449 442 PT 443
Cdd:cd17355 385 PI 386
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
7-209 |
2.87e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 64.90 E-value: 2.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 7 FFQPPKHIKEIEDQEVVKKKYKYWRIRIFYSMFIGY---IFYYFTRKSFTFAMPTLIADL-GFDKAQLGIIGSTLYFSYG 82
Cdd:cd17325 170 LLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFlaiFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASA 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 83 ISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVW 162
Cdd:cd17325 250 LSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLF 329
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 269302449 163 STSHNIGGALIPILTGFIIDYSGWRGAMYVPGILCIgMGLVLINRLR 209
Cdd:cd17325 330 NTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLL-LAAVLFLLLR 375
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
38-439 |
9.44e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 63.41 E-value: 9.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 38 MFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGM 117
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 118 SSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYS-GWRGAMYVPGIL 196
Cdd:cd17328 84 APNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 197 CIGMGLVLInrlrdtpqsLGLPPIEKYKRDPHHAHHEGKSASEGTeeierelstreilFTYVLTNQWLWFLAAASFFIYI 276
Cdd:cd17328 164 GVLLAILLL---------LFVREPPRGAAEGGVMAKSTATSFLAD-------------LKALAKNPSFILSTLGFTAVSF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 277 VRMAVNDWSALFL---IETKHYAAVKANFCVSLFE-IGGLFGMLVAGWLSDKISKGNRG--PMNVLFSLGLL--FAILGM 348
Cdd:cd17328 222 VTGALAFWAPTFFlraFGVGDLSSADVGLIFGAITcIAGVLGVLLGGILADRLRRKTPRadPLVCAVGLLAAapFLFLAL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 349 WFSRSHNQW-WVdgtLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAY-FGATFAGYPLGKVTDV------- 419
Cdd:cd17328 302 VLALSNLLLaWV---LLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHlLGDAGSPYLIGLISDLlrqnkds 378
|
410 420
....*....|....*....|..
gi 269302449 420 --WGWKGFFIALLACASIALLL 439
Cdd:cd17328 379 plAEAASLQYALLLCSFVLVLG 400
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
9-205 |
2.71e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.86 E-value: 2.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 9 QPPKHIKEIEDQEVVKKKYKYWRIRIFYSMFIGYIFYYFTRKSFTFAMPTLIAD-LGFDKAQLGIIGSTLYFSYGISKFV 87
Cdd:cd06173 184 AAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 88 SGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHN 167
Cdd:cd06173 264 LGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNS 343
|
170 180 190
....*....|....*....|....*....|....*...
gi 269302449 168 IGGALIPILTGFIIDYSGWRGAMYVPGILCIGMGLVLI 205
Cdd:cd06173 344 GAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLL 381
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
34-442 |
3.44e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.84 E-value: 3.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 34 IFYSMFIGYIFYYFTrksftfamptliADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRY-----FMAIGLMIT 108
Cdd:COG2211 24 LAFGLLSAYLLYFYT------------DVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 109 GLTNIF------FGMSSSIVLFALWWGLNGWFQGWGWPPCARL---LTHWYAksERGTWWSVWSTSHNIGGALIPILTGF 179
Cdd:COG2211 92 ALSFVLlftapdLSPTGKLIYALVTYLLLGLAYTLVNIPYSALgaeLTPDYE--ERTRLSSWRFAFAGLGGLLASVLPPP 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 180 IIDY------SGWRGAMYVPGILCIGMGLVLINRLRDTPQslglppiekykrdphhahhegksasegteEIERELSTREI 253
Cdd:COG2211 170 LVAAfggdaaLGYRLTALIFAVLGLLAFLLTFFGTKERPV-----------------------------PEEEKVSLKES 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 254 LFTyVLTNQWLWFLAAASFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKISKGNrgpm 333
Cdd:COG2211 221 LKA-LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKK---- 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 334 nvLFSLGLLFAILG---MWFSRSHNQWWVdgTLLFVIGFFLYGPQMMIGLA--------AAELSHKKAAGT--------- 393
Cdd:COG2211 296 --AFIIGLLLAALGlllLFFLGPGNLWLL--LVLAALAGIGLGAILVLPWAmladvvdyDEWKTGRRREGLyfgiftfai 371
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 269302449 394 --ASGFTGWFAYFGATFAGYPLGKVTD---VWGWKGFFI---ALLACASIALLLFLP 442
Cdd:COG2211 372 klGQALAGALAGLLLALFGYVAGAAQSpsaLTGIRLLFFllpAVLLLLAALLLLFYP 428
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
32-441 |
9.08e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 60.32 E-value: 9.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 32 IRIFYSMFIGYIFYYFTRksftfamptliaDLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLT 111
Cdd:cd17329 11 NRLGFFMVWPFMAIYLHQ------------QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 112 NIFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGwRGAMY 191
Cdd:cd17329 79 FALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF-RLLFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 192 VPGILCIGMGLVLINRLRdtpqslglppiekykrdphhaHHEGKSASEGTEEIERELSTreilftyVLTNQWLWFLAAAS 271
Cdd:cd17329 158 AAAVLFLLAALVLLFLLP---------------------ETRPKRRAAEKTEILRGYKI-------VLRDRAFLLFLLAS 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 272 FFIYivrMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKISKGNRGpmnVLFSLGLLFAILGMWFS 351
Cdd:cd17329 210 FLIS---LIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLR---KILMIGILLFAIGFAVL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 352 RSHNQ--WWVDGTLLFVIGFFLYGPqmMIGLAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWGWKGFFIAL 429
Cdd:cd17329 284 AFANTlaVLILAMIVLTLGEMLVFP--AVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLIL 361
|
410
....*....|..
gi 269302449 430 LACASIALLLFL 441
Cdd:cd17329 362 AALGLIAAALLL 373
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
55-441 |
4.45e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 57.97 E-value: 4.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 55 AMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWwglnGWF 134
Cdd:cd17320 21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIA----RFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 135 QGWGWPPCA----RLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMYVPGILCIGMGLVLINRLRD 210
Cdd:cd17320 97 QGLGAAAGSvvarAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 211 TPQSlglppiekykrdphhahHEGKSASEGTEEIERELSTREILFTYVLTNQwlwfLAAASFFIYIVRmavndwSALFLI 290
Cdd:cd17320 177 TLPE-----------------EKRKPLLSSLLRAYKRVLKNRRFLGYALALG----LSFAGLFAYLAA------APFIYI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 291 ETKHYAAvkANFcvSLFEIGGLFGMLVAGWLSDKISKGNRGPMNVLFSLGLLFA----ILGMWFSRSHNQWWVdgTLLFV 366
Cdd:cd17320 230 EQLGLSP--AQF--GLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAaalvLLLAALLGGLSLWPL--VAPLF 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 269302449 367 IGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWGWKgFFIALLACASIALLLFL 441
Cdd:cd17320 304 LIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALP-MGLLILVLGLLALLLLI 377
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
303-442 |
1.46e-08 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 56.51 E-value: 1.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 303 CVSLFEIGGLFGMLVAGWLSDKIskGNRGPM---NVLFSLGllfaILGMWFSRSHNQWWVDGTLLFVIGFFLYGPQMMIG 379
Cdd:pfam00083 51 IVSIFSVGCFIGSLFAGKLGDRF--GRKKSLliaNVLFVIG----AVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAP 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 269302449 380 LAAAELSHKKAAGTASGFTGWFAYFG---ATFAGYPLGKVTDVWGWKGFF--IALLACASIALLLFLP 442
Cdd:pfam00083 125 MYISEIAPKKLRGALGSLYQLAITFGillAYIFGLGLNKTSNSDGWRIPLglQLVPALLLIIGLLFLP 192
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
55-441 |
2.32e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 55.65 E-value: 2.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 55 AMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGWF 134
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 135 QGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSgWRGAMYVPGILCIgMGLVLINRLRDTPQS 214
Cdd:cd17474 101 AAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIS-WRYPFFLLAALIP-VAFLAILFLLPEPKE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 215 LGLPPIEKYKRDPHHAhhegksasegteeierelstreilftyvLTNQWLWFLAAASFFIYIVRMAVNDWSALFLIETKH 294
Cdd:cd17474 179 KAKSSSATKLRDLKKA----------------------------LRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 295 YAAVKANFCVSLFEIGGLFGMLVAGWLSDKISKGNRGPMNVLFSLGLLFAILGMWfsrsHNQWW-VDGTLLFVIGFFLYG 373
Cdd:cd17474 231 ISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFV----PSLALlLIAIVLFGLGLGLNL 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 269302449 374 PQMMIglAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWGWKGFFIALLACASIALLLFL 441
Cdd:cd17474 307 PLLTT--LVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
38-198 |
3.17e-08 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 55.25 E-value: 3.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 38 MFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGM 117
Cdd:cd17380 4 LFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 118 --SSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMYVPGI 195
Cdd:cd17380 84 laYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGL 163
|
...
gi 269302449 196 LCI 198
Cdd:cd17380 164 LGL 166
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
29-205 |
5.48e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 54.50 E-value: 5.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 29 YWRIRIFYSMFIGYIFYYFTRKSFTFAMPTLIAD-LGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNP---RYFMAIG 104
Cdd:cd17319 175 WFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQaRGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRgarRLVIIIG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 105 LMITGLTNIFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYS 184
Cdd:cd17319 255 LLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAT 334
|
170 180
....*....|....*....|...
gi 269302449 185 G-WRGAM-YVPGILCIGMGLVLI 205
Cdd:cd17319 335 GsYTAAFlFLAAVALLAALLVLL 357
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
37-442 |
6.30e-08 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 54.48 E-value: 6.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 37 SMFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIG--LMITGL---- 110
Cdd:cd17352 7 ASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGglLAALGLllss 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 111 --TNIFFGMSSSIVLFALWWGLNgwfqgwgWPPCARLLTHWYAKsERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRG 188
Cdd:cd17352 87 faTSLWQLYLTYGVLGGLGLGLI-------YSPAIVIVGQYFEK-KRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 189 AMYVPGILC-IGMGLVLINRLRdtpqslglppiekykRDPhhahhegksasegteeierelstreilfTYVLTNQWLwFL 267
Cdd:cd17352 159 ALLILGGLClNLCVCGLLLRLL---------------KDP----------------------------TFVLLALGV-SF 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 268 AAASFFIYIVRMAvndwsalFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKisKGNRGPMNVLFSLGLLF-AIL 346
Cdd:cd17352 195 AMLGFFVPFVYLP-------SYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADK--PRIGRLYLYIFTLLILGlSLL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 347 GMWFSRShnqWWVDGTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTgWFAYFGATFAGYPL-GKVTDVWG-WKG 424
Cdd:cd17352 266 AFPLATT---YVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLV-LLFQGLAALVGPPIaGLLRDYTGdYDA 341
|
410
....*....|....*...
gi 269302449 425 FFIALLACASIALLLFLP 442
Cdd:cd17352 342 AFYFCGACLLLSGVLLFL 359
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
51-439 |
8.77e-08 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 54.15 E-value: 8.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 51 SFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFAL-WWG 129
Cdd:cd17353 21 AWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLgYGV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 130 LNGWFQGWGWPPCARLLTHWYaKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMYVPGILCIGMGLVLINRLR 209
Cdd:cd17353 101 LGGIGAGIGYITPVSTAVKWF-PDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 210 DTPQSLglppiekykrdphhaHHEGKSASEGTEEIE-RELSTREILFTYVLTNQWLWFLAAASFFIYIVRMAvndwsALF 288
Cdd:cd17353 180 DPPKGW---------------VPPGVDPLANNAENSpRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQA-----KPI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 289 LIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKIskgnrGPMNVLFSLGLL--FAILGMWFSRSHnqwwvdgTLLFV 366
Cdd:cd17353 240 GQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKI-----GRKNTLSIAFLIqgVAMFLLPFIGSV-------AVLFV 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 367 IGFFLYGPQM--MIGLAAAELSHK---KAAGTASG--FTGWFayFGATFAGYPLGKVTDVWGWKGFFIALLACASIALLL 439
Cdd:cd17353 308 LGVALIGFCYggGFALFPALTADFfgtKNAGTNYGllYTAKG--VGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALAL 385
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
264-454 |
9.31e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 53.82 E-value: 9.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 264 LWFLAAASFFIYIVRMAVNdwSAL-FLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKIskgnrGPMNVLFSLGLL 342
Cdd:COG2814 12 LLALALGAFLSGLGIGIVL--PALpLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-----GRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 343 FAILGMWFSRSHNQWWVdGTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWGW 422
Cdd:COG2814 85 FALGSLLCALAPSLWLL-LAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190
....*....|....*....|....*....|..
gi 269302449 423 KGFFIALLACASIALLLFLPTWNATEKNTRSK 454
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPESRPAARAR 195
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
56-441 |
9.69e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 53.70 E-value: 9.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 56 MPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAI-GLMITGLTNIFFGMSSSIVLFALWWGLNGWF 134
Cdd:cd17370 22 LPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVIlGYGLSALAKPLLALAGSWQLVLLLRILERLG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 135 QGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGW--RGAMY---VPGILCIGMGLVlinrlr 209
Cdd:cd17370 102 KGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGnyRTIFLlaaIPALLALLILLF------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 210 dtpqslglppiekYKRDPHHAHHEGKSASEGteeIERELSTREILFTYVltnqwlWFLAAASFF---IYIVRMAVNDWSA 286
Cdd:cd17370 176 -------------VVKEYPRPPKLRKKSKKT---SLKKLPKAFWLYLLA------VALFALGNFsfaFLILRAQELGLSA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 287 LFLIETkhYAAvkANFCVSLFEigglfgmLVAGWLSDKISKGnrgpmnVLFSLGLLFAILG-MWFSRSHNQWWVdgtllf 365
Cdd:cd17370 234 ALIPLL--YAL--FNLVYALAA-------YPAGRLSDRIGRK------KLLILGYLSLALAyLGFALGSSLWLL------ 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 366 VIGFFLYGPQMMIGL-----AAAELSHKKAAGTASGF----TGWFAYFGATFAGYplgkVTDVWGWKGFFIALLACASIA 436
Cdd:cd17370 291 LLGFILWGLYMGAQEsieraAVADLVPAELRGTAYGLfntvVGIGWLLASLIAGY----LWDLISPSAAFLFSAVLALIA 366
|
....*
gi 269302449 437 LLLFL 441
Cdd:cd17370 367 LLLLL 371
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
56-409 |
1.00e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 53.86 E-value: 1.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 56 MPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGWFQ 135
Cdd:cd17333 19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 136 GWGwPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYS-GWRGAMYVPGILCIGMGLVLINrlrdtpqs 214
Cdd:cd17333 99 GIL-DTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSElSWSWAYLIIGLIYLLLAILILL-------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 215 lglppiEKYKRDPHHAHHEGKSASEGTEEIERELstreilftyvltNQWLWFLAAASFFIYIVRMAVNDWSALFLIETKH 294
Cdd:cd17333 170 ------TLFPELPSARNPQQSVGAFSASASRLLR------------NPSIILGALALFLYVGAETAFSSWVPSYLVEKKH 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 295 YAAVKANFCVSLFEIGGLFGMLVAGWLSDKIskgnrGPMNVLFsLGLLFAILGMWFSrshnqWWVDGTLLFVIGFFLYG- 373
Cdd:cd17333 232 VSDGLAGYLLSGFWVGITIGRLLGGPISRRI-----KPHTLLV-LSGSGALLGLLIL-----LLAPTLVVGLVATALLGl 300
|
330 340 350
....*....|....*....|....*....|....*....
gi 269302449 374 ---PQMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFA 409
Cdd:cd17333 301 fmaALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAII 339
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
56-440 |
1.66e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 52.95 E-value: 1.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 56 MPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGWFQ 135
Cdd:cd17477 19 LSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 136 GWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGfIIDYSGWrgAMYVPGILCIGMGLVLINRLRDTPqsl 215
Cdd:cd17477 99 AGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLA-LVGTAGA--LPFLIAAVLLLLALVPLLLTRRAA--- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 216 glPPIEKykrdphhahhegksasegteeiERELSTREILFTyvltnqwLWFLAAASFFIYIVRMAVNDWSALFLIEtKHY 295
Cdd:cd17477 173 --PEIEE----------------------AESISLRRLLRI-------APLALLGAFVAGFLEGAFYSLLPLYGLR-LGL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 296 AAVKANFCVSLFEIGGLFGMLVAGWLSDKISKgnRGPMNVLFSLGLLFAILGMWFSrshNQWWVDGTLLFVIGFFLYGPQ 375
Cdd:cd17477 221 SVAQAALLLAAFVLGGLLLQWPLGWLADRFDR--RRVLLGCALLGALAALLLPLVP---GLPLALLVLLFLWGGAAGPLY 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 269302449 376 -MMIGLAAAELSHKKAAGTASGFTGWFAyFGATFAGYPLGKVTDVWGWKGFFIALLACASIALLLF 440
Cdd:cd17477 296 tLALALAGDRLPGDELVAANAALLLLYG-LGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
56-438 |
3.18e-07 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 52.26 E-value: 3.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 56 MPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGWFQ 135
Cdd:cd17393 22 IPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAAN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 136 GWgwppCARLLTHWYAKSERGTWWSVWSTSHNIG--GALIPILTGFIIdySGWRGAMYV----PGILCIGMGLVLINRLR 209
Cdd:cd17393 102 GA----LDVAMNAQGVAVERAYGRPIMSSLHAMWslGGLAGALLGAAA--IGAGVSPGVhllaAAVLLLLAALVAIRALL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 210 DTPQslglppiekyKRDPHHAHHEGKSASegteeierelstreilftyVLTNQWLWFLAAASFFIYIVRMAVNDWSALFL 289
Cdd:cd17393 176 PGTG----------EAAEDRPDGAGKPGF-------------------LLPNRLLLLLGLLALAAALAEGAAADWSALYL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 290 IETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKIskgnrGPMNVLFSLGLLfAILGMWFS-RSHNQWWVdgtllfVIG 368
Cdd:cd17393 227 RDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRF-----GDVAVLRAGALL-AALGLLLAlLAPSVWVA------LAG 294
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 269302449 369 FFLYG-------PQMMiglAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWGWK-GFFIALLACASIALL 438
Cdd:cd17393 295 FALMGlglsvvvPLAF---SAAGALPGLAAGIAVARVATLGYLGFLVGPPLIGFLADATGLRtAFLVVALLALLVALL 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
29-172 |
6.32e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.13 E-value: 6.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 29 YWRIRIFYSMFIGYIFYYFTRKSFTFAMPTLIAD-LGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMI 107
Cdd:COG2814 203 LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 269302449 108 TGLTNIFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGAL 172
Cdd:COG2814 283 LALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
52-370 |
7.06e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.08 E-value: 7.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 52 FTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAI------GLMITGLTNIFFGMSSSIVLFA 125
Cdd:cd06173 18 FTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllraLLAAVLALLALLGSLSLWLLLV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 126 LWwGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMYVPGILCIGMGLVLi 205
Cdd:cd06173 98 LA-FLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLL- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 206 nrlrdtpqsLGLPPIEKYKRDPHHAHHEGKSasegteeierelstrEILFTYVLTNQWLWFLAAASFFIYIVRMAVNDWS 285
Cdd:cd06173 176 ---------LFIRRPPPAAPGESSSLLLRDL---------------REGLRYLRRSPLLRLLLLALALFALLGGALTVLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 286 ALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKIskgNRGPMNVLFSLGLLFAILGMWFSRShnqWWVDGTLLF 365
Cdd:cd06173 232 PLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR---RRGRLLLIGALLLGLALLVLGLSPS---LWLLLAALF 305
|
....*
gi 269302449 366 VIGFF 370
Cdd:cd06173 306 LLGLA 310
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
7-205 |
8.27e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 51.03 E-value: 8.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 7 FFQPPKHIKEIEDQEVVKKKY-KYWRIRIFYSMFIGYIFYYFTRKSFTFAMPTLIADL-GFDKAQLGIIGSTLYFSYGIS 84
Cdd:cd17474 171 FLLPEPKEKAKSSSATKLRDLkKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLyGISPIIIGLLFAGWSVLLALG 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 85 KFVSG-VMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWS 163
Cdd:cd17474 251 SLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYN 330
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 269302449 164 TSHNIGGALIPILTGFIIDYSGWRGAMYVPGILCIGMGLVLI 205
Cdd:cd17474 331 FVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
267-443 |
1.10e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.49 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 267 LAAASFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKIskgnrGPMNVLFSLGLLFAIL 346
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF-----GRRRVLLIGLLLFALG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 347 GMWFSRSHNQWWVdGTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWGWKG-F 425
Cdd:pfam07690 76 LLLLLFASSLWLL-LVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAaF 154
|
170
....*....|....*...
gi 269302449 426 FIALLACASIALLLFLPT 443
Cdd:pfam07690 155 LILAILSLLAAVLLLLPR 172
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
32-375 |
1.38e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 50.33 E-value: 1.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 32 IRIFYSMFIGYIFYYFTRKSFTFA----MPTliaDLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMI 107
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAavmgMKE---DLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 108 TGLTNIF-FGMSSSIVLFALWWgLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPIL-TGFII---- 181
Cdd:cd17327 81 WGLLTLLtAAVKNFGGLIALRF-FLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLaYGVFKilgv 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 182 -DYSGWRGAMYVPGILCIGMGLVLINRLRDTPQ-SLGLPPIEK-YKRDPHHAHHEGKsaseGTEEIERElstreiLFTYV 258
Cdd:cd17327 160 gGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSkAWFLTEEEKeLAVERLRANQTGK----GDQKFKWK------QIKEA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 259 LTNQWLWFLAAASFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLfGMLVAGWLSDKISKgnRGP----MN 334
Cdd:cd17327 230 FKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAV-SLLIAALLSDRFKK--RGLfaifAC 306
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 269302449 335 VLFSLGllFAILGMWFSRSHNQWwvdgtLLFVIGFFLYGPQ 375
Cdd:cd17327 307 VLALVG--SIILLAAPNPPGAYF-----AAYILGGGSYAGF 340
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
56-440 |
1.43e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 50.33 E-value: 1.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 56 MPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGWFQ 135
Cdd:cd17341 22 GPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 136 GWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALI----PILTGFII---DYSGWRGAMYVPGILCIGMGLVLINRL 208
Cdd:cd17341 102 GANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSqllaPLIAGAIVfdgGFVGWRNAFFVPGILLAIAAVLVLLFG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 209 RDTPQSlglppiekyKRDPHHAHHEgksasegteeierelstreilFTYVLTNQWLWFLAAASFFIYIVRMAVNDWSALF 288
Cdd:cd17341 182 DDLPTG---------KASALEFLKV---------------------QLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTY 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 289 LIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKIskGNRGPMNVLFSLGLLFAILGMWFSRSHNQwwvdGTLLFVIG 368
Cdd:cd17341 232 FKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRF--GGRRRLWWLFIVMTIGAALLSLSLPTSGT----NLVLFLAL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 369 FFLygpqMMIGLAAAELS--------HKKAAGTASGFTGWFAYFGATFAGYPLGKVTDVWGWKGFFIALLACASIALLLF 440
Cdd:cd17341 306 FVA----LGLGAGAGNGSvfrmvpfiFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLL 381
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
57-196 |
6.78e-06 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 48.00 E-value: 6.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 57 PTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSI--VLFALWWGLNGWF 134
Cdd:cd17318 45 PVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGgyGALIVLRILQGLA 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 269302449 135 QGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMYVPGIL 196
Cdd:cd17318 125 QGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGL 186
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
3-205 |
1.19e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 3 VWTKFFQPPKHIKEIEDQEVVKKKYKYWR--IRIFYSMFIGYIFYYftrkSFTFAMPTLIADLG-FDKAQLGIIGSTLYF 79
Cdd:cd17473 169 VLLFLPEPARKSKSAASPGAATAAALPWKrvLPIYFLAFLAMLLFY----VIPIQLPFLLQERGgGSAALIGLALAIASL 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 80 SYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWW 159
Cdd:cd17473 245 AGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAM 324
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 269302449 160 SVWSTSHNIGGALIPILTGFII-DYSGWRGAMYVPGILCIGMGLVLI 205
Cdd:cd17473 325 GIVTSAFFLGQFLSPLVLGPLVnLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
30-214 |
1.26e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 47.18 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 30 WRIRIFYSMFIGYIFYYFTRKSFTFAMPTLIAD-LGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMIT 108
Cdd:COG2223 202 LRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALM 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 109 GLTNIFFGMSS-SIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSG-W 186
Cdd:COG2223 282 ALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsY 361
|
170 180
....*....|....*....|....*....
gi 269302449 187 RGAMYVPGILC-IGMGLVLINRLRDTPQS 214
Cdd:COG2223 362 TAAFLVFAVLAlVALVLTLLLYRRPRRAA 390
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
53-444 |
2.70e-05 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 46.46 E-value: 2.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 53 TFAMPTLIA----DLGFDKAQLGI--IGStlyFSYGI-SKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFA 125
Cdd:PLN00028 52 TFAAAPLLPiirdNLNLTKSDIGNagIAS---VSGSIfSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFI 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 126 L----------------WW----------GL-NGWFQGWGwppcarllthwyaksergtwwsvwstshNIGGA----LIP 174
Cdd:PLN00028 129 AvrffigfslatfvscqYWmstmfngkivGTaNGIAAGWG----------------------------NLGGGvtqlLMP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 175 ILTGFIID-----YSGWRGAMYVPGILCIGMGLVLINRLRDTPQSlglppieKYKRDPHHAHHEGKSASEgteeierels 249
Cdd:PLN00028 181 LVFPLIKDagapsFTAWRIAFFVPGLLHIIMGILVLTLGQDLPDG-------NYRELKKSGTMPKDSFSK---------- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 250 treiLFTYVLTNQWLWFLAAASFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKISK-- 327
Cdd:PLN00028 244 ----VLRYGVTNYRTWILALTYGYSFGVELTMDNIIAEYFYDRFGLSLETAGAIAASFGLMNLFARPAGGYLSDVAARrf 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 328 GNRGPMNVLFSLGLLFAILGMWFSRSHNQWwvdGTLLFVIGFflygpqmMIGLAAAELSH--------KKAAGTASGFTG 399
Cdd:PLN00028 320 GMRGRLWALWIVQTLGGVFCIWLGRANSLG---AAIVVMILF-------SIFVQAACGATfgivpfvsRRSLGVISGLTG 389
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 269302449 400 WFAYFGATFAGYPLGKVTDVWGWKGFF---IALLACASIALLLFLPTW 444
Cdd:PLN00028 390 AGGNVGAVLTQLLFFTGSSYSTETGISlmgVMIIACTLPVAFIHFPQW 437
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
3-174 |
3.70e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.49 E-value: 3.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 3 VWTKFFQPPKHIKEIEDQEVVKKKYKYWRIRIFYSMFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYG 82
Cdd:pfam07690 170 LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGA 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 83 ISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWG---LNGWFQGWGWPPCARLLTHWYAKSERGTWW 159
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLallLLGFGFGLVFPALNALVSDLAPKEERGTAS 329
|
170
....*....|....*
gi 269302449 160 SVWSTSHNIGGALIP 174
Cdd:pfam07690 330 GLYNTAGSLGGALGP 344
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
145-438 |
4.79e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 45.26 E-value: 4.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 145 LLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYsGWRGAMYVpgilcIGMGLVLinrlrdtpqslgLPPIEKYK 224
Cdd:cd17473 112 LIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLV-----YLLALPV------------LILVLLFL 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 225 RDPHHAHhegKSASEGTEEIERELSTREILFTYVLTnqwlwFLAAASFFIYIVRMavndwsALFLIETKHYAAVKANFCV 304
Cdd:cd17473 174 PEPARKS---KSAASPGAATAAALPWKRVLPIYFLA-----FLAMLLFYVIPIQL------PFLLQERGGGSAALIGLAL 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 305 SLFEIGGLFGMLVAGWLSDKISKGNrgpmnvLFSLGLLFAILG-MWFSRSHNQWWVDGTLLFV-IGFFLYGPQMMigLAA 382
Cdd:cd17473 240 AIASLAGAIGALLFGRLKRRLGKRR------LLAIGFALMALGfLLLALASGLWVVLLGAILAgLGFGLLLPTLN--SWA 311
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 269302449 383 AELSHKKAAGTASGFTGWFAYFGA-------TFAGYPLGKVTDVWGWKGFFIALLACASIALL 438
Cdd:cd17473 312 MSLVPPELRGRAMGIVTSAFFLGQflsplvlGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MFSD7 |
cd17399 |
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ... |
300-397 |
5.76e-05 |
|
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340957 Cd Length: 419 Bit Score: 45.34 E-value: 5.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 300 ANFCVSLFEIGGLFGMLVAGWLSDKiSKGNRGPMNVLFSLGLLFAILGMWFSRSHNQWWVDGTLLFVIGFFLYgPQMMIG 379
Cdd:cd17399 256 AGICGALMIGVGLIGAFVAGLIVDK-TKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLCGLFGFFGF-AIYPVG 333
|
90
....*....|....*....
gi 269302449 380 LA-AAELSHKKAAGTASGF 397
Cdd:cd17399 334 LElAVECTYPVAEATSTGL 352
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
43-406 |
6.18e-05 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 44.99 E-value: 6.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 43 IFYYFTRKSFTFAMPTLI-----ADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGM 117
Cdd:TIGR00886 7 WFGFFLSFLVWFAFSPLAvflikDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 118 SSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIID----------YSGWR 187
Cdd:TIGR00886 87 AVQSYSVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGslifgggqpaHLAWG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 188 GAMY-VPGILCIGMGLVLINRLRDTPQslglppiekykrdphhahheGKSAsegteeiERELSTREILftYVLTNQWLWF 266
Cdd:TIGR00886 167 WAFViVPAGILLLPALLIFFVGADTPP--------------------GKPA-------TGKLSFKEAL--KVFGNRHTWI 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 267 LAAASFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKISKGNRGPMNVlfsLGLLFAIL 346
Cdd:TIGR00886 218 LALLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNF---LGVAMGAF 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 347 GMWFSRSHNQWWVDGTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGA 406
Cdd:TIGR00886 295 LVVLGLVSDGSLAAFIVLFVALFFFAGAGNGSTFALVPHIFRRATGAVSGLIGAIGNLGG 354
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
29-205 |
8.23e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.51 E-value: 8.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 29 YWRIRIFYSMFIgYIFYYFTRKSFTFAMPT-LIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMI 107
Cdd:cd17316 174 LLRRRTLLLILL-WFFISFGYYGLTTFLPTyLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 108 TGLTNIFFGM--SSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSV-WSTSHNIGGALIPILTGFIIDYS 184
Cdd:cd17316 253 SGILALPLFYllSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLsYNLGRLGGGGAPPLIALLLASTG 332
|
170 180
....*....|....*....|.
gi 269302449 185 GWRGAMYVPGILCIGMGLVLI 205
Cdd:cd17316 333 GTGVPALILALLAIVALIVAL 353
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
27-205 |
1.58e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 43.70 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 27 YKYWRIRIFYSMFIGYIFYYFTRKSFTFAMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPR--YFMAIG 104
Cdd:cd17352 177 LRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGrlYLYIFT 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 105 LMITGLTNIFFGMSSSIVLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYS 184
Cdd:cd17352 257 LLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYT 336
|
170 180
....*....|....*....|..
gi 269302449 185 G-WRGAMYVPGILCIGMGLVLI 205
Cdd:cd17352 337 GdYDAAFYFCGACLLLSGVLLF 358
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
56-136 |
8.46e-04 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 41.44 E-value: 8.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 56 MPTLIADLGFDKAQLGIIGSTlyfsYGISKFVS----GVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLN 131
Cdd:cd17390 19 LSTHIRSLGASPTVIGLIGSV----YGALQLFSsplvGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPL 94
|
....*
gi 269302449 132 GWFQG 136
Cdd:cd17390 95 GIFKH 99
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
301-442 |
8.48e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 41.48 E-value: 8.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 301 NFCVSLFEIGGLFGMLVAGWLSDKIskGNRGPMNVLFSLGLLFAILgMWFSRshnqwWVDGTLLFVIGFFLYGPQMMIGL 380
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRF--GRKNGLLISNALLVVSSLL-MFLSK-----SAKSPELLIFGRFLVGIACGLST 123
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 269302449 381 AAA-----ELSHKKAAGTASGFTGWFAYFGATFAG-----YPLGKVTDvWGWKGFFIALLACASIALLLFLP 442
Cdd:cd17357 124 GFVpmylqEISPSELRGALGSLTQIGVTLGILLGQvfglpSVLGTETL-WPYLLFFPGIPALLQLAALPFFP 194
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
168-383 |
1.00e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 41.10 E-value: 1.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 168 IGGALIPILTGFIIDYSGWRGAMYVPGILCIGMGLVLINRLRDTPQSLglppiekykrdphhAHHEGKSASEGTEEI--- 244
Cdd:PRK11551 150 FGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFA--------------QAAGAGKQRAPVLRAlfg 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 245 -ERELSTREILFTYVLTNQWLWFLAaasffiyivrmavnDWSALFLIEtKHYAAVKANFCVSLFEIGGLFGMLVAGWLSD 323
Cdd:PRK11551 216 eGRATATLLLWISYFFTLIVLYFLL--------------NWLPSLLVG-QGLSRSQAGLVQIAFNIGGALGSLLIGALMD 280
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 269302449 324 KIskgNRGPMNVLFSLGLLFAILGMWFSRSHNQWWVDGtllFVIGFFLYGPQMMI-GLAAA 383
Cdd:PRK11551 281 RL---RPRRVVLLIYAGILASLAALAAAPSFAGMLLAG---FAAGLFVVGGQSVLyALAPL 335
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
56-181 |
1.23e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 40.80 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 56 MPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGWFQ 135
Cdd:TIGR00895 273 LPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFV 352
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 269302449 136 GWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFII 181
Cdd:TIGR00895 353 NGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
151-441 |
1.42e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 40.74 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 151 AKSERGTWWSVWSTSHNIGGALIPILTGFIIDYS---------GWRGAMYVPGILCIgMGLVLINRLRDTPQSLglppie 221
Cdd:cd17367 130 APPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTlgedqmaawGWRIPFLLGGVLAV-VVLWLRRGLEETESFE------ 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 222 kykrdphhAHHEGKSASEGT-EEIERElsTREILFTYVLTnqwlwflAAASFFIYivrmAVNDWSALFLIETKHYAAVKA 300
Cdd:cd17367 203 --------AIAESNEASAGTlRELRRH--PRELLLVVGLT-------AGGTLAFY----TWTTYLQKFLVNTAGFSKGDA 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 301 NFCVSLFEIGGLFGMLVAGWLSDKISkgnRGPMNVLFSLGLLFAILGMWFS-RSHNQWWVDGTLLFVIGFFLYGPQMMIG 379
Cdd:cd17367 262 TWITTAALLVFMLLQPLGGRLSDRIG---RRPLLLFFGIGGTLATVPLLSAlDHTDSPYTAFALVLVGLVFLSGYTSINA 338
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 269302449 380 LAAAEL--SHKKAAGTASGFTGWFAYFGATfAGYPLGKVTDVWGWKGFFIALLACASIALLLFL 441
Cdd:cd17367 339 VVKAELfpTHVRALGVGLPYALAVAIFGGT-APYVALWLKSIGHEWVFFWYVAGLIAISLVVYL 401
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
55-371 |
1.74e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 40.64 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 55 AMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGWF 134
Cdd:cd17503 18 ALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 135 QGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMYV---PGILCIGMGLVLinRLRdt 211
Cdd:cd17503 98 GGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYInlpIGILALLLAPLL--DLR-- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 212 pqslglppiekykrdphhahhegksasegteeierelstreilftyVLTNQWLWFLAAASFFIYIVRMAVNDWSALFLIE 291
Cdd:cd17503 174 ----------------------------------------------LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQN 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 292 TKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKIskGNRGPMNVLFSLGLLFAILGMWFSrSHNQWWVDGTLLFVIGFFL 371
Cdd:cd17503 208 VLGYSAFESGLVLAPGGLASAILSPLVGRLLDKF--GPRLLLLAGLLLLALGTLLLAFLT-PDTSLWLIILPLFIRGLGM 284
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
266-440 |
2.05e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.20 E-value: 2.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 266 FLAAASFFIYIVrmavndWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKIskGNRGPMNVLFSLGLLFAI 345
Cdd:cd17369 238 LAENVLFYLFTT------FALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRV--GRRPVYLAGALLAALFAF 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 346 LGMWFSRSHNQWWVDGTLLFVIGFF---LYGPQmmiGLAAAEL--SHKKAAGTASGF---TGWFAYFGATFAGYpLGKVT 417
Cdd:cd17369 310 PFFWLLDTGSTWLIVLAAVVVLGVLhgmMYGPQ---AAFLAELfpTRVRYTGASLGYqlgAILGGGFAPLIATA-LVAAT 385
|
170 180
....*....|....*....|...
gi 269302449 418 DVWGWKGFFIALLACASIALLLF 440
Cdd:cd17369 386 GSWWPVALYLAALAVISLVAALF 408
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
264-370 |
3.98e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.13 E-value: 3.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 264 LWFLAAASFFIYIVRMAVNDWSALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKISkgnRGPMNVLFSLGLLF 343
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFG---RKPVMLAGLLLRAL 77
|
90 100
....*....|....*....|....*..
gi 269302449 344 AILGMWFsrsHNQWWVDGTLLFVIGFF 370
Cdd:cd17329 78 GFALLGF---AHSPWLFAIALVLTGFG 101
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
43-205 |
5.36e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 39.10 E-value: 5.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 43 IFYYFTRKSFTFAMPTLIADLGFDkAQLGIIGSTLYF-SYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSI 121
Cdd:cd17323 9 FVVTFGSSIYSPALPQIAEDFHVS-EEVANLGVSLFVlGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 122 VLFALWWGLNGWFQGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMYvpgILCIGMG 201
Cdd:cd17323 88 AMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFW---FLAIISG 164
|
....
gi 269302449 202 LVLI 205
Cdd:cd17323 165 FCLI 168
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
264-444 |
5.58e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.95 E-value: 5.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 264 LWFLAAASFFIYIVRMAVndwsALFLIETKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKIskgnrGPMNVLFSLGLLF 343
Cdd:cd06174 1 LLLGFFLTGLARGLISPL----LPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF-----GRRPVLLLGLLLF 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 344 AILGMWFSRSHNQWWVdGTLLFVIGFFLYGPQMMIGLAAAELSHKKAAGTASGFTGWFAYFGATFaGYPLGKVTDVWGWK 423
Cdd:cd06174 72 ALGALLFAFAPSFWLL-LLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGIL-GPLLGGILASSLGF 149
|
170 180
....*....|....*....|.
gi 269302449 424 GFFIALLACASIALLLFLPTW 444
Cdd:cd06174 150 GWRAVFLIAAALALLAAILLL 170
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
55-213 |
5.84e-03 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 38.90 E-value: 5.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 55 AMPTLIADLGFDKAQLGIIGSTLYFSYGISKFVSGVMSDQSNPRYFMAIGLMITGLTNIFFGMSSSIVLFALWWGLNGWF 134
Cdd:TIGR00711 24 AIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 135 QGWGWPPCARLLTHWYAKSERGTWWSVWSTSHNIGGALIPILTGFIIDYSGWRGAMYV---PGILCIGMGLVLINrlRDT 211
Cdd:TIGR00711 104 GGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLInvpIGIIVVVVAFFILP--RDK 181
|
..
gi 269302449 212 PQ 213
Cdd:TIGR00711 182 PA 183
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
270-451 |
8.52e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.34 E-value: 8.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 270 ASFFIYIVRMAVNDWSALFLIEtKHYAAVKANFCVSLFEIGGLFGMLVAGWLSDKIskgnrGPMNVLFSLGLLFAILGMW 349
Cdd:cd17489 4 ANFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRF-----GRKRLLLIGLLIFALATLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 350 FSRSHNQWWvdgtllFVIGFFLYGPQM-----MIGLAAAELSHKKAAGTASGFTGWFAYFGATFAGyPLGK-VTDVWGWK 423
Cdd:cd17489 78 YLLATSVAL------LLVLRLIHGIGWgafttAAATLVADIIPPSRRGEGIGYYGLATTLAMALGP-ALGLfLYQHLGFA 150
|
170 180
....*....|....*....|....*...
gi 269302449 424 GFFIALLACASIALLLFLPTWNATEKNT 451
Cdd:cd17489 151 VLFIVAAVLALLALLLVFLVKDPPPVAA 178
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
294-442 |
9.40e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 37.94 E-value: 9.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 294 HYAAVKANFCVSLFEIGGLFGMLVAGWLSDKIskgnrGPMNVLFSLGLLFaILGMWFSRSHNQWWVDGTLLFVIGFFlyg 373
Cdd:cd17315 30 GLSTSLQGLVVSSLLLGAAIGSLFGGPLADRF-----GRRKSLLIAAVLY-VIGALLSALAPNVWVLIVGRFLLGLG--- 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269302449 374 pqmmIGLAA-------AELSHKKAAGTASGFTGWFAYFG---ATFAGYPLGKVTDVWgWKGFF--IALLACASIALLLFL 441
Cdd:cd17315 101 ----VGLASvlvplyiSEIAPAKIRGALGTLNQLMITFGillAYLLGLALSLSPPGW-WRLMFalAAVPALLQLLLMFFL 175
|
.
gi 269302449 442 P 442
Cdd:cd17315 176 P 176
|
|
| |
