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Conserved domains on  [gi|272476863|gb|ACZ94846|]
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uncharacterized protein Dmel_CG18249, isoform B [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-433 2.72e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 2.72e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 105 LTSLQMQGTSLGVLRDQIFNAVPRLEILQLSQNFIHTVHVAAFQGLSKLRLLGLQGNaiaeilsSTLDPLMELVHLDLSR 184
Cdd:COG4886   50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSG 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 185 NELTTLPQNIfAKNKKLQTLLLNGNPLRILmPDVLGSLPNLRLLDLGHA--AELEVMTLNLTNVQNLVLEGSSLSSLvin 262
Cdd:COG4886  123 NQLTDLPEEL-ANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNqlTDLPEELGNLTNLKELDLSNNQITDL--- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 263 ggfiklqagnnelnHLQVGNKSSVIEMDLHGNLLNgnDTAALLRGMWNLQRLDLSKNRIEALPqhgsgldasgtqELLIL 342
Cdd:COG4886  198 --------------PEPLGNLTNLEELDLSGNQLT--DLPEPLANLTNLETLDLSNNQLTDLP------------ELGNL 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 343 PSLKFLNLANNQLVRLPPESPIlsSRLSYLDLSHNLMLTLDVAILRSLSVLKGLYVEGNRLNTINYQKLHEEHPDLSELG 422
Cdd:COG4886  250 TNLEELDLSNNQLTDLPPLANL--TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLL 327

                        330
                 ....*....|.
gi 272476863 423 LHDNPWSSGLY 433
Cdd:COG4886  328 LLLKGLLVTLT 338
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-433 2.72e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 2.72e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 105 LTSLQMQGTSLGVLRDQIFNAVPRLEILQLSQNFIHTVHVAAFQGLSKLRLLGLQGNaiaeilsSTLDPLMELVHLDLSR 184
Cdd:COG4886   50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSG 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 185 NELTTLPQNIfAKNKKLQTLLLNGNPLRILmPDVLGSLPNLRLLDLGHA--AELEVMTLNLTNVQNLVLEGSSLSSLvin 262
Cdd:COG4886  123 NQLTDLPEEL-ANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNqlTDLPEELGNLTNLKELDLSNNQITDL--- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 263 ggfiklqagnnelnHLQVGNKSSVIEMDLHGNLLNgnDTAALLRGMWNLQRLDLSKNRIEALPqhgsgldasgtqELLIL 342
Cdd:COG4886  198 --------------PEPLGNLTNLEELDLSGNQLT--DLPEPLANLTNLETLDLSNNQLTDLP------------ELGNL 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 343 PSLKFLNLANNQLVRLPPESPIlsSRLSYLDLSHNLMLTLDVAILRSLSVLKGLYVEGNRLNTINYQKLHEEHPDLSELG 422
Cdd:COG4886  250 TNLEELDLSNNQLTDLPPLANL--TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLL 327

                        330
                 ....*....|.
gi 272476863 423 LHDNPWSSGLY 433
Cdd:COG4886  328 LLLKGLLVTLT 338
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
176-436 9.87e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.17  E-value: 9.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 176 ELVHLDLSRNELTTLPQNIFAknkKLQTLLLNGNPLRILmPDvlgSLPN-LRLLDLGHAAELEVMTLNLTNVQNLVLEGS 254
Cdd:PRK15370 200 QITTLILDNNELKSLPENLQG---NIKTLYANSNQLTSI-PA---TLPDtIQEMELSINRITELPERLPSALQSLDLFHN 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 255 SLSSLVIN--GGFIKLQAGNNELNHLQVGNKSSVIEMDLHGNLLngndTAALLRGMWNLQRLDLSKNRIEALPQHgsgld 332
Cdd:PRK15370 273 KISCLPENlpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSL----TALPETLPPGLKTLEAGENALTSLPAS----- 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 333 asgtqellILPSLKFLNLANNQLVRLPPESPilsSRLSYLDLSHNLMLTLDVAILRSLSVLKGLYVEGNRLNTiNYQKLH 412
Cdd:PRK15370 344 --------LPPELQVLDVSKNQITVLPETLP---PTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPE-SLPHFR 411

                        250       260
                 ....*....|....*....|....
gi 272476863 413 EEHPDLSELGLHDNPWSSGLYRKM 436
Cdd:PRK15370 412 GEGPQPTRIIVEYNPFSERTIQNM 435
LRR_8 pfam13855
Leucine rich repeat;
104-163 3.56e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 3.56e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863  104 NLTSLQMQGTSLGVLRDQIFNAVPRLEILQLSQNFIHTVHVAAFQGLSKLRLLGLQGNAI 163
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 305-427 1.77e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 1.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 305 LRGMWNLQRLDLSKNRIEALpqhgSGLDAsgtqelliLPSLKFLNLANNqlvRLPPESPI---------LSSRLSYLDLS 375
Cdd:cd21340   64 LENLVNLKKLYLGGNRISVV----EGLEN--------LTNLEELHIENQ---RLPPGEKLtfdprslaaLSNSLRVLNIS 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 272476863 376 HNLMLTLDVaiLRSLSVLKGLYVEGNRLNTINYQKLHEEH-PDLSELGLHDNP 427
Cdd:cd21340  129 GNNIDSLEP--LAPLRNLEQLDASNNQISDLEELLDLLSSwPSLRELDLTGNP 179
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-433 2.72e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 2.72e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 105 LTSLQMQGTSLGVLRDQIFNAVPRLEILQLSQNFIHTVHVAAFQGLSKLRLLGLQGNaiaeilsSTLDPLMELVHLDLSR 184
Cdd:COG4886   50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSG 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 185 NELTTLPQNIfAKNKKLQTLLLNGNPLRILmPDVLGSLPNLRLLDLGHA--AELEVMTLNLTNVQNLVLEGSSLSSLvin 262
Cdd:COG4886  123 NQLTDLPEEL-ANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNqlTDLPEELGNLTNLKELDLSNNQITDL--- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 263 ggfiklqagnnelnHLQVGNKSSVIEMDLHGNLLNgnDTAALLRGMWNLQRLDLSKNRIEALPqhgsgldasgtqELLIL 342
Cdd:COG4886  198 --------------PEPLGNLTNLEELDLSGNQLT--DLPEPLANLTNLETLDLSNNQLTDLP------------ELGNL 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 343 PSLKFLNLANNQLVRLPPESPIlsSRLSYLDLSHNLMLTLDVAILRSLSVLKGLYVEGNRLNTINYQKLHEEHPDLSELG 422
Cdd:COG4886  250 TNLEELDLSNNQLTDLPPLANL--TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLL 327

                        330
                 ....*....|.
gi 272476863 423 LHDNPWSSGLY 433
Cdd:COG4886  328 LLLKGLLVTLT 338
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
97-407 2.79e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 2.79e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863  97 ESLRPVENLTSLQMQGTSLGVLRDQIFNAvPRLEILQLSQNFIHTVHvAAFQGLSKLRLLGLQGNAIAEIlSSTLDPLME 176
Cdd:COG4886  107 EELSNLTNLESLDLSGNQLTDLPEELANL-TNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTN 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 177 LVHLDLSRNELTTLPQNIfAKNKKLQTLLLNGNPLRILmPDVLGSLPNLRLLDLGHAA--ELEVMTlNLTNVQNLVLEGS 254
Cdd:COG4886  184 LKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQltDLPELG-NLTNLEELDLSNN 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 255 SLSSLVINGGFIKLQAGNNELNHLQVGNKSSVIEMDLHGNLLNGNDTAALLRGMWNLQRLDLSKNRIEALPQHGSGLDAS 334
Cdd:COG4886  261 QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 272476863 335 GTQELLILPSLKFLNLANNQLVRLPPESPILSSRLSYLDLSHNLMLTLDVAILRSLSVLKGLYVEGNRLNTIN 407
Cdd:COG4886  341 ALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-321 1.00e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863  56 QLRELHLRNCSRQSITWLVLQLTpGLRTLVIRNCATYHISkESLRPVENLTSLQMQGTSLGVLRDQIFNaVPRLEILQLS 135
Cdd:COG4886  114 NLESLDLSGNQLTDLPEELANLT-NLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGN-LTNLKELDLS 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 136 QNFIHTVHvAAFQGLSKLRLLGLQGNAIAEiLSSTLDPLMELVHLDLSRNELTTLPQ--------------------NIF 195
Cdd:COG4886  191 NNQITDLP-EPLGNLTNLEELDLSGNQLTD-LPEPLANLTNLETLDLSNNQLTDLPElgnltnleeldlsnnqltdlPPL 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 196 AKNKKLQTLLLNGNPLRILMPDVLGSLPNLRLLDLGHAAELEVMTLNLTNVQNLVLEGSSLSSLVINGGFIKLQAGNNEL 275
Cdd:COG4886  269 ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLA 348

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 272476863 276 NHLQVGNKSSVIEMDLHGNLLNGNDTAALLRGMWNLQRLDLSKNRI 321
Cdd:COG4886  349 LLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
176-436 9.87e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.17  E-value: 9.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 176 ELVHLDLSRNELTTLPQNIFAknkKLQTLLLNGNPLRILmPDvlgSLPN-LRLLDLGHAAELEVMTLNLTNVQNLVLEGS 254
Cdd:PRK15370 200 QITTLILDNNELKSLPENLQG---NIKTLYANSNQLTSI-PA---TLPDtIQEMELSINRITELPERLPSALQSLDLFHN 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 255 SLSSLVIN--GGFIKLQAGNNELNHLQVGNKSSVIEMDLHGNLLngndTAALLRGMWNLQRLDLSKNRIEALPQHgsgld 332
Cdd:PRK15370 273 KISCLPENlpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSL----TALPETLPPGLKTLEAGENALTSLPAS----- 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 333 asgtqellILPSLKFLNLANNQLVRLPPESPilsSRLSYLDLSHNLMLTLDVAILRSLSVLKGLYVEGNRLNTiNYQKLH 412
Cdd:PRK15370 344 --------LPPELQVLDVSKNQITVLPETLP---PTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPE-SLPHFR 411

                        250       260
                 ....*....|....*....|....
gi 272476863 413 EEHPDLSELGLHDNPWSSGLYRKM 436
Cdd:PRK15370 412 GEGPQPTRIIVEYNPFSERTIQNM 435
LRR_8 pfam13855
Leucine rich repeat;
104-163 3.56e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 3.56e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863  104 NLTSLQMQGTSLGVLRDQIFNAVPRLEILQLSQNFIHTVHVAAFQGLSKLRLLGLQGNAI 163
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 150-403 5.81e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.62  E-value: 5.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 150 LSKLRLLGLQGNAIAEILSSTLDPLMELVHLDLSRNELTTLPQNIFAKNKKLQTLLLNGNPLRILMPDVLGSLPNLRLL- 228
Cdd:PLN00113 259 LKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLq 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 229 ------------DLGHAAELEVMTLNLTNvqnlvLEGSSLSSLVINGGFIKLQAGNNELNH---LQVGNKSSVIEMDLHG 293
Cdd:PLN00113 339 lwsnkfsgeipkNLGKHNNLTVLDLSTNN-----LTGEIPEGLCSSGNLFKLILFSNSLEGeipKSLGACRSLRRVRLQD 413

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 294 NLLNGNdtaaLLRGMWNLQR---LDLSKNRIealpqhgSGLDASGTQElliLPSLKFLNLANNQLVRLPPESpILSSRLS 370
Cdd:PLN00113 414 NSFSGE----LPSEFTKLPLvyfLDISNNNL-------QGRINSRKWD---MPSLQMLSLARNKFFGGLPDS-FGSKRLE 478

                        250       260       270
                 ....*....|....*....|....*....|...
gi 272476863 371 YLDLSHNLMLTLDVAILRSLSVLKGLYVEGNRL 403
Cdd:PLN00113 479 NLDLSRNQFSGAVPRKLGSLSELMQLKLSENKL 511
LRR_8 pfam13855
Leucine rich repeat;
127-211 1.14e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863  127 PRLEILQLSQNFIHTVHVAAFQGLSKLRllglqgnaiaeilsstldplmelvHLDLSRNELTTLPQNIFAKNKKLQTLLL 206
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLK------------------------VLDLSNNLLTTLSPGAFSGLPSLRYLDL 56


                  ....*
gi 272476863  207 NGNPL 211
Cdd:pfam13855  57 SGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 98-377 1.37e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.39  E-value: 1.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863  98 SLRPVENLTSLQMQGTSLGVLRDQIFNAVPRLEILQL-SQNFIHTVHVAaFQGLSKLRLLGLQGNAIAEILSSTLDPLME 176
Cdd:PLN00113 279 SIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLfSNNFTGKIPVA-LTSLPRLQVLQLWSNKFSGEIPKNLGKHNN 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 177 LVHLDLSRNELTTLPQNIFAKNKKLQTLLLNGNPLRILMPDVLG---SLPNLRLLDLGHAAELEVMTLNLTNVQNLVLEG 253
Cdd:PLN00113 358 LTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGacrSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISN 437

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 254 SSLSSlvinggfiKLQAGNNELNHLQVgnkssvieMDLHGNLLNGNDTAALlrGMWNLQRLDLSKNRI-EALPQhgsgld 332
Cdd:PLN00113 438 NNLQG--------RINSRKWDMPSLQM--------LSLARNKFFGGLPDSF--GSKRLENLDLSRNQFsGAVPR------ 493

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 272476863 333 asgtqELLILPSLKFLNLANNQLVRLPPESpiLSS--RLSYLDLSHN 377
Cdd:PLN00113 494 -----KLGSLSELMQLKLSENKLSGEIPDE--LSSckKLVSLDLSHN 533
LRR_8 pfam13855
Leucine rich repeat;
176-232 1.78e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 1.78e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 272476863  176 ELVHLDLSRNELTTLPQNIFAKNKKLQTLLLNGNPLRILMPDVLGSLPNLRLLDLGH 232
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 104-232 7.11e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.08  E-value: 7.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 104 NLTSLQMqgtsLGVLRDQIFNAVP------RLEILQLSQNFIHTVHVAAFQGLSKLRLLGLQGNAIAEILSSTLDPLMEL 177
Cdd:PLN00113 450 DMPSLQM----LSLARNKFFGGLPdsfgskRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKL 525

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 272476863 178 VHLDLSRNELTTLPQNIFAKNKKLQTLLLNGNPLRILMPDVLGSLPNLRLLDLGH 232
Cdd:PLN00113 526 VSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISH 580
LRR_8 pfam13855
Leucine rich repeat;
343-403 1.55e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.55e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 272476863  343 PSLKFLNLANNQLVRLPPESPILSSRLSYLDLSHNLMLTLDVAILRSLSVLKGLYVEGNRL 403
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 305-427 1.77e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 1.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 305 LRGMWNLQRLDLSKNRIEALpqhgSGLDAsgtqelliLPSLKFLNLANNqlvRLPPESPI---------LSSRLSYLDLS 375
Cdd:cd21340   64 LENLVNLKKLYLGGNRISVV----EGLEN--------LTNLEELHIENQ---RLPPGEKLtfdprslaaLSNSLRVLNIS 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 272476863 376 HNLMLTLDVaiLRSLSVLKGLYVEGNRLNTINYQKLHEEH-PDLSELGLHDNP 427
Cdd:cd21340  129 GNNIDSLEP--LAPLRNLEQLDASNNQISDLEELLDLLSSwPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
310-379 2.39e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 2.39e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863  310 NLQRLDLSKNRIEALPQHGsgldasgtqeLLILPSLKFLNLANNQLVRLPPESPILSSRLSYLDLSHNLM 379
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGA----------FKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 150-223 4.51e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 4.51e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 272476863 150 LSKLRLLGLQGNAIAEILSSTLDPLMELVHLDLSRNELTTLPQNIFAKNKKLQTLLLNGNPLRILMPDVLGSLP 223
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGRL 514
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
237-430 9.01e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 9.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 237 EVMTLNLTNVQNLVLEGSSLSSLVINGGFIKLQAGNNELNHLQVGNKSSVIEMDLHGNLLNGNDTAALLRGMWNLQRLDL 316
Cdd:COG4886    8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 317 SKNRIEALPQHGSgLDASGTQELLILPSLKFLNLANNQLVRLPPESPILSSrLSYLDLSHNLMLTLDVAiLRSLSVLKGL 396
Cdd:COG4886   88 GLTDLGDLTNLTE-LDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTN-LKELDLSNNQLTDLPEP-LGNLTNLKSL 164

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 272476863 397 YVEGNRLNTINY--QKLheehPDLSELGLHDNPWSS 430
Cdd:COG4886  165 DLSNNQLTDLPEelGNL----TNLKELDLSNNQITD 196
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 124-404 4.58e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 4.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 124 NAVPRLEILQLSQNFIHTVHVAAFQGLSKLRLLGLQGNAIAEILSSTLDPL-MELVHLDLSRNELTTLPQNIFAKNkkLQ 202
Cdd:PLN00113  66 NNSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTsSSLRYLNLSNNNFTGSIPRGSIPN--LE 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 203 TLLLNGNPLRILMPDVLGSLPNLRLLDLGHAAELEVMTLNLTNVQNlvLEGSSLSSLVINGG------------FIKLqa 270
Cdd:PLN00113 144 TLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTS--LEFLTLASNQLVGQiprelgqmkslkWIYL-- 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 271 GNNELNH---LQVGNKSSVIEMDLHGNLLNGNDTAAlLRGMWNLQRLDLSKNRiealpqhgsgLDASGTQELLILPSLKF 347
Cdd:PLN00113 220 GYNNLSGeipYEIGGLTSLNHLDLVYNNLTGPIPSS-LGNLKNLQYLFLYQNK----------LSGPIPPSIFSLQKLIS 288

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 272476863 348 LNLANNQLVRLPPESPILSSRLSYLDL-SHNLMLTLDVAiLRSLSVLKGLYVEGNRLN 404
Cdd:PLN00113 289 LDLSDNSLSGEIPELVIQLQNLEILHLfSNNFTGKIPVA-LTSLPRLQVLQLWSNKFS 345
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 123-253 5.39e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 5.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 123 FNAVPRLEILQLSQNFIhtVHVAAFQGLSKLRLLGLQGNAIAEIlsSTLDPLMELVHLDLSR------NELTTLPQNIFA 196
Cdd:cd21340   42 LEFLTNLTHLYLQNNQI--EKIENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENqrlppgEKLTFDPRSLAA 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 272476863 197 KNKKLQTLLLNGNPLRILMPdvLGSLPNLRLLDLGH-----AAELEVMTLNLTNVQNLVLEG 253
Cdd:cd21340  118 LSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNnqisdLEELLDLLSSWPSLRELDLTG 177
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 107-438 7.50e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.88  E-value: 7.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 107 SLQMQGTSLGVLR-DQIFNAVPRLEILQLSQNFIHTVHVAAfqglsklrllglqgnaiaeiLSSTLDPLMELVHLDLSRN 185
Cdd:cd00116    2 QLSLKGELLKTERaTELLPKLLCLQVLRLEGNTLGEEAAKA--------------------LASALRPQPSLKELCLSLN 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 186 ELTTLPQNIfaknkklqtlllngnplrILMPDVLGSLPNLRLLDLG------HAAELEVMTLNLTNVQNLVLEGSSLSsl 259
Cdd:cd00116   62 ETGRIPRGL------------------QSLLQGLTKGCGLQELDLSdnalgpDGCGVLESLLRSSSLQELKLNNNGLG-- 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 260 viNGGFIKLQAGnneLNHLQvgnkSSVIEMDLHGNLLNGNDTAAL---LRGMWNLQRLDLSKNRIealpqHGSGLdASGT 336
Cdd:cd00116  122 --DRGLRLLAKG---LKDLP----PALEKLVLGRNRLEGASCEALakaLRANRDLKELNLANNGI-----GDAGI-RALA 186

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 272476863 337 QELLILPSLKFLNLANNQL----VRLPPESPILSSRLSYLDLSHNL-----MLTLDVAILRSLSVLKGLYVEGNRLNTIN 407
Cdd:cd00116  187 EGLKANCNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNNltdagAAALASALLSPNISLLTLSLSCNDITDDG 266

                        330       340       350
                 ....*....|....*....|....*....|....
gi 272476863 408 YQKLHE---EHPDLSELGLHDNPWSSGLYRKMFL 438
Cdd:cd00116  267 AKDLAEvlaEKESLLELDLRGNKFGEEGAQLLAE 300
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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