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Conserved domains on  [gi|291334217|gb|ADD93883|]
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hypothetical protein [uncultured marine bacterium MedDCM-OCT-S08-C1463]

Protein Classification

porin family protein( domain architecture ID 229388)

porin family protein is a member of a large superfamily consisting of classical (gram-negative ) porins which are non-specific channels for small hydrophillic molecules, maltoporin-like channels which have specificities for various sugars, and ligand-gated protein channels which cooperate with a TonB associated inner membrane complex to actively transport ligands via the proton motive force

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CirA super family cl34327
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
2-207 1.04e-28

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG1629:

Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 119.55  E-value: 1.04e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   2 QDVPIAVSAFTDEVLADRQIEYASDLQLQVPGLSYSSNTFSGGGFSIRGITnfltaaSGDAGVEVHINGAPL-----GTT 76
Cdd:COG1629   16 QDVPGSVSVISREQLEDQPATDLGDLLRRVPGVSVTSAGGGAGQISIRGFG------GGGNRVLVLVDGVPLndpsgGDG 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  77 STNEIGYLDMSRVEVLRGPQGTLFGRNSTGGVVNMITNVPDlDAFSGSANIQYGADAEKMIKMMLNVPiSDTLGARFAIS 156
Cdd:COG1629   90 GLSYIDPEDIERVEVLRGPSSALYGSGALGGVINIVTKKPK-DGKGGEVSASYGSYGTYRASLSLSGG-NGKLAYRLSAS 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 291334217 157 TFERDGvtknlnsaaTDDFDNRDSYMWRASFRWEADDDLTLDFMHQAYDEE 207
Cdd:COG1629  168 YRDSDG---------YRDNSDSDRYNLRAKLGYQLGDDTRLTLSASYSDSD 209
 
Name Accession Description Interval E-value
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
2-207 1.04e-28

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 119.55  E-value: 1.04e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   2 QDVPIAVSAFTDEVLADRQIEYASDLQLQVPGLSYSSNTFSGGGFSIRGITnfltaaSGDAGVEVHINGAPL-----GTT 76
Cdd:COG1629   16 QDVPGSVSVISREQLEDQPATDLGDLLRRVPGVSVTSAGGGAGQISIRGFG------GGGNRVLVLVDGVPLndpsgGDG 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  77 STNEIGYLDMSRVEVLRGPQGTLFGRNSTGGVVNMITNVPDlDAFSGSANIQYGADAEKMIKMMLNVPiSDTLGARFAIS 156
Cdd:COG1629   90 GLSYIDPEDIERVEVLRGPSSALYGSGALGGVINIVTKKPK-DGKGGEVSASYGSYGTYRASLSLSGG-NGKLAYRLSAS 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 291334217 157 TFERDGvtknlnsaaTDDFDNRDSYMWRASFRWEADDDLTLDFMHQAYDEE 207
Cdd:COG1629  168 YRDSDG---------YRDNSDSDRYNLRAKLGYQLGDDTRLTLSASYSDSD 209
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 8-227 1.67e-18

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 88.28  E-value: 1.67e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   8 VSAFTDEVLADRQIEYASDLQLQVPGLSYSSNTFSGG-GFSIRGItnfltaasGDAGVEVHINGAPLGTTSTNEIGYLD- 85
Cdd:cd01347    2 VSVITAEDIEKQPATSLADLLRRIPGVSVTRGGGGGGsTISIRGF--------GPDRTLVLVDGLPLASSNYGRGVDLNt 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  86 -----MSRVEVLRGPQGTLFGRNSTGGVVNMITnVPDLDAFSGSANIQYGADAEKMIK---MMLNVPISDTLGARFAIST 157
Cdd:cd01347   74 ippelIERVEVLKGPSSALYGSGAIGGVVNIIT-KRPTDEFGGSVTAGYGSDNSGSSGgggFDVSGALADDGAFGARLYG 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217 158 FERDGVTKNLNSAATDDfDNRDSYMWRASFRWEADDDLTLDFMHQAYDEESARTQRQGAFCEVGGNAVQG 227
Cdd:cd01347  153 AYRDGDGTIDGDGQADD-SDEERYNVAGKLDWRPDDDTRLTLDAGYQDQDADGPGGTLPANGTGSSLGGG 221
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 2-108 2.06e-15

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 71.92  E-value: 2.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217    2 QDVPIAVSAFTDEVLADRQIEYASDLQLQVPGLSYSSNTFSGGG-FSIRGItnfltaasGDAGVEVHINGAPL-----GT 75
Cdd:pfam07715   3 RDTPGSVSVVTAEDIEDQGATNLADALRGVPGVSVSSGGGGGGSsISIRGF--------GSNRVLVLVDGVPLnsgggGS 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 291334217   76 TSTNEIGYLDMSRVEVLRGPQGTLFGRNSTGGV 108
Cdd:pfam07715  75 VDLNSIDPEDIERVEVLKGPASALYGSGAIGGV 107
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 3-153 7.06e-13

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 70.90  E-value: 7.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217    3 DVPIAVSAFTDEVLADRQIEYASDLQLQVPGL--SYSSNTFSGGGFSIRGItnfltAASGDAGVeVHINGAPLgtTSTNE 80
Cdd:TIGR01783   1 DIPQSVSVITRQELEDQQAGSLSEALQRVPGVvvGGSGGTTQFGNITIRGF-----GLEVDIDN-VYLDGVPL--LSRGN 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 291334217   81 IGYLDMS---RVEVLRGPQGTLFGRNSTGGVVNMITNVPDlDAFSGSANIQYGADAEKMIKMMLNVPI--SDTLGARF 153
Cdd:TIGR01783  73 LAIVDPAmveRVEVLRGPASLLYGGSAPGGVINIVTKRPQ-DEPKGSVTFGAGTRSGYRTAFDLGGPLgaDGTFRGRL 149
PRK10064 PRK10064
catecholate siderophore receptor CirA; Provisional
 1-215 1.12e-08

catecholate siderophore receptor CirA; Provisional


Pssm-ID: 236646 [Multi-domain]  Cd Length: 663  Bit Score: 57.59  E-value: 1.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   1 MQDVPIAVSAFTDEVLADRQIEYASDLQLQVPGLSYSSNTFSGGGFSIRGITNFLTAasgdagveVHINGAPLGTTS--- 77
Cdd:PRK10064  44 LKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRGLDSSYTL--------ILIDGKRVNSRNavf 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  78 ------TNEIGYLDMSRVEVLRGPQGTLFGRNSTGGVVNMITNvPDLDAFSGS----ANIQYGADAEKMIKMMLNVP--- 144
Cdd:PRK10064 116 rhndfdLNWIPVDAIERIEVVRGPMSSLYGSDALGGVVNIITK-KIGQKWHGTvtvdTTIQEHRDRGDTYNGQFFTSgpl 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217 145 ISDTLGARF--AISTFERDGVTKNLNSAA-----TDDFDNRDSymwRASFRWEADDD----LTLDFMHQAYDEES---AR 210
Cdd:PRK10064 195 IDGVLGMKAygSLAKREKDDPQNSTTTDTgetprIEGFTSRDG---NVEFAWTPNQNhdftAGYGFDRQDRDSDSldkNR 271


                 ....*
gi 291334217 211 TQRQG 215
Cdd:PRK10064 272 LERQN 276
 
Name Accession Description Interval E-value
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
2-207 1.04e-28

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 119.55  E-value: 1.04e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   2 QDVPIAVSAFTDEVLADRQIEYASDLQLQVPGLSYSSNTFSGGGFSIRGITnfltaaSGDAGVEVHINGAPL-----GTT 76
Cdd:COG1629   16 QDVPGSVSVISREQLEDQPATDLGDLLRRVPGVSVTSAGGGAGQISIRGFG------GGGNRVLVLVDGVPLndpsgGDG 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  77 STNEIGYLDMSRVEVLRGPQGTLFGRNSTGGVVNMITNVPDlDAFSGSANIQYGADAEKMIKMMLNVPiSDTLGARFAIS 156
Cdd:COG1629   90 GLSYIDPEDIERVEVLRGPSSALYGSGALGGVINIVTKKPK-DGKGGEVSASYGSYGTYRASLSLSGG-NGKLAYRLSAS 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 291334217 157 TFERDGvtknlnsaaTDDFDNRDSYMWRASFRWEADDDLTLDFMHQAYDEE 207
Cdd:COG1629  168 YRDSDG---------YRDNSDSDRYNLRAKLGYQLGDDTRLTLSASYSDSD 209
Fiu COG4774
Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];
2-207 5.16e-24

Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];


Pssm-ID: 443806 [Multi-domain]  Cd Length: 639  Bit Score: 105.34  E-value: 5.16e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   2 QDVPIAVSAFTDEVLADRQieyASDLQ--LQ-VPGLSySSNTFSGGG--FSIRGItnfltaasgDAGVEVHINGAPLGTT 76
Cdd:COG4774    7 LDTPQSVTVVTRELIEDQG---ATSLAdaLRnVPGVT-FGAGEGGNGdsFSIRGF---------SASGDIYVDGLRDPGQ 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  77 STNEIGYLDmsRVEVLRGPQGTLFGRNSTGGVVNMITNVPDLDAFsGSANIQYGADAEKMIKMMLNVPISDTLGARFais 156
Cdd:COG4774   74 YRRDTFNLE--RVEVLKGPASVLYGRGSPGGVINLVTKRPTDEPF-TEVTLTYGSDGQRRATLDVNGPLGDDLAYRL--- 147

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 291334217 157 tferDGVTKNLNSAAtdDFDNRDSYMWRASFRWEADDDLTLDFMHQAYDEE 207
Cdd:COG4774  148 ----NGMYRDSDSYR--DGVDNDRWGIAPSLTWRLGDRTRLTLDYEYQDDD 192
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 2-216 1.42e-21

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 97.62  E-value: 1.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   2 QDVPIAVSAFTDEVLADRQIEYASDLQLQVPGLSYSSNTFSGGG--FSIRGItnfltaasGDAGVEVHINGAPLGTTSTN 79
Cdd:COG4771   42 SDAPASVSVITAEEIEKLGATDLADALRLLPGVSVTRSGGRGGSsgISIRGL--------GGDRVLVLIDGVPVNNPALG 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  80 EIGYL------DMSRVEVLRGPQGTLFGRNSTGGVVNMITNVPDlDAFSGSANIQYGADAEKMIK--MMLNVPiSDTLGA 151
Cdd:COG4771  114 GGGDLsyippdDIERIEVIRGPASALYGSDAIGGVINIITKKPT-DELEGSVSLGYGSNGNGTYSgsLSLGGP-GDKLSF 191

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291334217 152 RFAISTFERDGvTKNLNSAATDDFDNRDSYMWRASFRWEADDDLTLDFMHQAYDEESARTQRQGA 216
Cdd:COG4771  192 LLSGSYRDRDG-YLDYRNGGFVGNSGYERYNLNAKLGYRLSDNHRLSLSGGYSRQDRDGGPPTLG 255
FhuE COG4773
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion ...
 3-210 9.23e-20

Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism];


Pssm-ID: 443805 [Multi-domain]  Cd Length: 692  Bit Score: 92.27  E-value: 9.23e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   3 DVPIAVSAFTDEVLADRQIEYASDLQLQVPGLSYSSN-TFSGGGFSIRG--ITNFLtaasgdagvevhINGAPLGTTSTn 79
Cdd:COG4773   64 ETPQSVSVVTRQLIEDQGATTLDDALRNVPGVTVSSYdGGGRDSFSIRGfsIDNYL------------RDGLPLGGFGG- 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  80 eiGYLDMS---RVEVLRGPQGTLFGRNSTGGVVNMITNVPdLDAFSGSANIQYG--------ADaekmikmmLNVPISD- 147
Cdd:COG4773  131 --GQPDTAnleRVEVLKGPAGLLYGAGSPGGLVNLVTKRP-TAEPQGEVSLSAGswdtyratAD--------VGGPLNEd 199

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 291334217 148 -TLGARFAISTFERDGVTknlnsaatdDFDNRDSYMWRASFRWEADDD--LTLDFMHQAYDEESAR 210
Cdd:COG4773  200 gTLRYRLNAAYEDGDSFR---------DGVDNRRTLIAPSLDWDLTDDttLTLGAEYQDDDSTGDR 256
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 8-227 1.67e-18

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 88.28  E-value: 1.67e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   8 VSAFTDEVLADRQIEYASDLQLQVPGLSYSSNTFSGG-GFSIRGItnfltaasGDAGVEVHINGAPLGTTSTNEIGYLD- 85
Cdd:cd01347    2 VSVITAEDIEKQPATSLADLLRRIPGVSVTRGGGGGGsTISIRGF--------GPDRTLVLVDGLPLASSNYGRGVDLNt 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  86 -----MSRVEVLRGPQGTLFGRNSTGGVVNMITnVPDLDAFSGSANIQYGADAEKMIK---MMLNVPISDTLGARFAIST 157
Cdd:cd01347   74 ippelIERVEVLKGPSSALYGSGAIGGVVNIIT-KRPTDEFGGSVTAGYGSDNSGSSGgggFDVSGALADDGAFGARLYG 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217 158 FERDGVTKNLNSAATDDfDNRDSYMWRASFRWEADDDLTLDFMHQAYDEESARTQRQGAFCEVGGNAVQG 227
Cdd:cd01347  153 AYRDGDGTIDGDGQADD-SDEERYNVAGKLDWRPDDDTRLTLDAGYQDQDADGPGGTLPANGTGSSLGGG 221
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 2-108 2.06e-15

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 71.92  E-value: 2.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217    2 QDVPIAVSAFTDEVLADRQIEYASDLQLQVPGLSYSSNTFSGGG-FSIRGItnfltaasGDAGVEVHINGAPL-----GT 75
Cdd:pfam07715   3 RDTPGSVSVVTAEDIEDQGATNLADALRGVPGVSVSSGGGGGGSsISIRGF--------GSNRVLVLVDGVPLnsgggGS 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 291334217   76 TSTNEIGYLDMSRVEVLRGPQGTLFGRNSTGGV 108
Cdd:pfam07715  75 VDLNSIDPEDIERVEVLKGPASALYGSGAIGGV 107
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
3-208 9.78e-15

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 74.14  E-value: 9.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   3 DVPIAVSAFTDEVLADRQIEYASDLQLQVPGLSYSSNTFSGGG--FSIRGITNFLTAASGDaGVEvhINGAPLGTTSTNE 80
Cdd:COG4206   14 DLTGSVTVIDAEELERSGATSLADALRRVPGVQVSSSGGPGSAasISIRGLGSNQTLVLID-GVP--LNDPSLGGVDLSL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  81 IGYLDMSRVEVLRGPQGTLFGRNSTGGVVNMITNVPDlDAFSGSANIQYGAD--AEKMIKMMLNvpiSDTLGARFAISTF 158
Cdd:COG4206   91 IPPDDIERIEVLKGAASALYGSDAIGGVINITTKKGK-KGFKGSVSASYGSFgtRRLSASLSGG---AGKFSYSLSASYR 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 291334217 159 ERDGVTKNLNSAATDDFDNRDSYMWRASFRWeaDDDLTLDFMHQAYDEES 208
Cdd:COG4206  167 RSDGYRYNDPDLRNNDGYENTSLNARLGYKL--GDNGSLSLSGGYSDSER 214
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 3-153 7.06e-13

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 70.90  E-value: 7.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217    3 DVPIAVSAFTDEVLADRQIEYASDLQLQVPGL--SYSSNTFSGGGFSIRGItnfltAASGDAGVeVHINGAPLgtTSTNE 80
Cdd:TIGR01783   1 DIPQSVSVITRQELEDQQAGSLSEALQRVPGVvvGGSGGTTQFGNITIRGF-----GLEVDIDN-VYLDGVPL--LSRGN 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 291334217   81 IGYLDMS---RVEVLRGPQGTLFGRNSTGGVVNMITNVPDlDAFSGSANIQYGADAEKMIKMMLNVPI--SDTLGARF 153
Cdd:TIGR01783  73 LAIVDPAmveRVEVLRGPASLLYGGSAPGGVINIVTKRPQ-DEPKGSVTFGAGTRSGYRTAFDLGGPLgaDGTFRGRL 149
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
2-208 3.01e-11

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 65.72  E-value: 3.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   2 QDVPIAVSAFTDEVLADRQIEYASDLQLQVPGLsYSSNTFSGG---GFSIRGitnflTAASGDAGVE-----VHINGAPL 73
Cdd:COG4772   39 KDVPGSVSVVDREELENQAATSLREVLRRVPGV-NVQEEDGFGlrpNIGIRG-----LGPRRSRGITlledgIPIAPAPY 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  74 GTTStneiGYLD-----MSRVEVLRGPQGTLFGRNSTGGVVNMITNVPDlDAFSGSANIQYGADAEKmikmMLNVPISDT 148
Cdd:COG4772  113 GDPA----AYYFpdlerMERIEVLRGAAALRYGPQTVGGAINFVTRTIP-TAFGGELRVTGGSFGYR----RTHASVGGT 183

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 291334217 149 ---LGARFAISTFERDGVTKNlnsaatDDFDnRDSYMwrASFRWEADDDLTLDFMHQAYDEES 208
Cdd:COG4772  184 vgnFGYLVEYSRKRGDGFRDN------SGFD-INDFN--AKLGYRLSDRQELTLKFQYYDEDA 237
TonB-hemin TIGR01785
TonB-dependent heme/hemoglobin receptor family protein; This model represents the ...
 1-201 3.95e-11

TonB-dependent heme/hemoglobin receptor family protein; This model represents the TonB-dependent outer membrane heme/hemoglobin receptor/transporter found in bacteria which live in contact with animals (which contain hemoglobin or other heme-bearing globins) or legumes (which contain leghemoglobin). Some species having hits to this model such as Nostoc, Caulobacter and Chlorobium do not have an obvious source of hemoglobin-like proteins in their biological niche and so the possibility exists that they act on some other substance. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273807 [Multi-domain]  Cd Length: 665  Bit Score: 65.11  E-value: 3.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217    1 MQDVPIAVSAFTDEVLADRQIEYASDLQLQVPGLSYSSNTFSGG-GFSIRGItnfltaasGDAGVEVHINGAPLGTT--- 76
Cdd:TIGR01785  15 LSEAPASVSVISGEQIESKQANNLADALNTVPGVDVTGGGRPPGqSINIRGL--------QDNRVLVVVDGARQNYQrgg 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   77 STNEIGYLDMS---RVEVLRGPQGTLFGRNSTGGVVNMIT-NVPDL----DAFSGSANIQYG-ADAEKMIKMMLNVPISD 147
Cdd:TIGR01785  87 AHNGSLFVDPEllkRIEIVKGPSSSLYGSGALGGVVAFRTkDAADLlrpgQLFGGLAKLSYGsNNNSFGGSVAVAGRLDD 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 291334217  148 TLgaRFAISTFERDG-VTKNLN--SAATDDFDNRDSYMwraSFRWEADDDLTLDFMH 201
Cdd:TIGR01785 167 NL--DALVAATYRDGgNYRNGNkeEATNSAYVQKNLLA---KLGWQLDDAQRLEFSY 218
PRK10064 PRK10064
catecholate siderophore receptor CirA; Provisional
 1-215 1.12e-08

catecholate siderophore receptor CirA; Provisional


Pssm-ID: 236646 [Multi-domain]  Cd Length: 663  Bit Score: 57.59  E-value: 1.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   1 MQDVPIAVSAFTDEVLADRQIEYASDLQLQVPGLSYSSNTFSGGGFSIRGITNFLTAasgdagveVHINGAPLGTTS--- 77
Cdd:PRK10064  44 LKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRGLDSSYTL--------ILIDGKRVNSRNavf 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  78 ------TNEIGYLDMSRVEVLRGPQGTLFGRNSTGGVVNMITNvPDLDAFSGS----ANIQYGADAEKMIKMMLNVP--- 144
Cdd:PRK10064 116 rhndfdLNWIPVDAIERIEVVRGPMSSLYGSDALGGVVNIITK-KIGQKWHGTvtvdTTIQEHRDRGDTYNGQFFTSgpl 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217 145 ISDTLGARF--AISTFERDGVTKNLNSAA-----TDDFDNRDSymwRASFRWEADDD----LTLDFMHQAYDEES---AR 210
Cdd:PRK10064 195 IDGVLGMKAygSLAKREKDDPQNSTTTDTgetprIEGFTSRDG---NVEFAWTPNQNhdftAGYGFDRQDRDSDSldkNR 271


                 ....*
gi 291334217 211 TQRQG 215
Cdd:PRK10064 272 LERQN 276
PRK13484 PRK13484
IreA family TonB-dependent siderophore receptor;
1-180 3.97e-07

IreA family TonB-dependent siderophore receptor;


Pssm-ID: 139605 [Multi-domain]  Cd Length: 682  Bit Score: 52.70  E-value: 3.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   1 MQDVPIAVSAFTDEVLADRQIEYASDLQLQVPGLSYSSNTfSGGGFSIRGI----TNFLTAASGDAGVEVHINGaplgtT 76
Cdd:PRK13484  44 LRNAPASVSVITSEQLQKKPVSDLVDAVKDVEGISITGGN-EKPDISIRGLsgdyTLILVDGRRQSGRESRPNG-----S 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  77 STNEIGYLD----MSRVEVLRGPQGTLFGRNSTGGVVNMITNVPDLDAFSGSAN----IQYGADAEKMIK--MMLNVP-I 145
Cdd:PRK13484 118 GGFEAGFIPpveaIERIEVIRGPMSSLYGSDAIGGVINIITKPVNNQTWDGVLGlggiIQEHGKFGNSTTndFYLSGPlI 197

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 291334217 146 SDTLGARFAISTFER--DGVTK------NLNSAATDDFDNRDS 180
Cdd:PRK13484 198 KDKLGLQLYGGMNYRkeDSISQgtpakdNKNITATLQFTPTES 240
PRK13524 PRK13524
FepA family TonB-dependent siderophore receptor;
88-215 6.60e-07

FepA family TonB-dependent siderophore receptor;


Pssm-ID: 237410 [Multi-domain]  Cd Length: 744  Bit Score: 51.95  E-value: 6.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  88 RVEVLRGPQGTLFGRNSTGGVVNMITNVPDlDAFSGSANIQYGA---DAEKMIKMM---LNVPISDTLGARfaistferd 161
Cdd:PRK13524 148 RIEVLRGPAAARYGNGAAGGVVNIITKKPT-GEWHGSWNTYFNApehKAEGATKRTnfsLSGPLGDELSFR--------- 217

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 291334217 162 gVTKNLNSAATDDFD-------------------------NRDSymwRASFRWEADDDLTLDFmhqaydeeSARTQRQG 215
Cdd:PRK13524 218 -LYGNLNKTQADAWDinqghqsartgsyagtlpagregviNKDI---NGLLRWDFAPLQSLEL--------EAGYSRQG 284
PRK13483 PRK13483
ligand-gated channel protein;
1-150 7.09e-07

ligand-gated channel protein;


Pssm-ID: 184080 [Multi-domain]  Cd Length: 660  Bit Score: 51.70  E-value: 7.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   1 MQDVPIAVSAFTDEVLADRQIEYASDLQLQVPGLsyssnTFSGGG----FSIRGI----TNFLTAASGDAGVEVHINGAP 72
Cdd:PRK13483  47 IRDAPASISVITREDLENRFYRDLTDALLDVPGV-----VVTGGGdrtdISLRGMgsqyTLILVDGKRQSSRETRPNSDG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  73 LGTTS--TNEIGYLDmsRVEVLRGPQGTLFGRNSTGGVVNMIT-NVPD-------LDAF----SGSANIQYGadaekmiK 138
Cdd:PRK13483 122 PGVEQawTPPLAAIE--RIEVIRGPMSSLYGSDAIGGVINIITrKVPNewqgevrLDTTlqenSDSGNVYQA-------N 192

                        170
                 ....*....|...
gi 291334217 139 MMLNVP-ISDTLG 150
Cdd:PRK13483 193 FFVNGPlIKDLLG 205
PRK13513 PRK13513
ligand-gated channel protein;
1-113 7.70e-07

ligand-gated channel protein;


Pssm-ID: 184104 [Multi-domain]  Cd Length: 659  Bit Score: 51.69  E-value: 7.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   1 MQDVPIAVSAFTDEVLADRQIEYASDLQLQVPGLsyssnTFSGGG----FSIRGITNFLTAasgdagveVHINGAPLGTT 76
Cdd:PRK13513  49 IQDAPASISVVTREQLENKAYRDVTDALKDVPGV-----VVTGGGstsdISIRGMAAKYTL--------ILVDGKRVDTR 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 291334217  77 STN--------EIGYLD----MSRVEVLRGPQGTLFGRNSTGGVVNMIT 113
Cdd:PRK13513 116 STRpnsdgsgiEQGWLPplaaIERIEVVRGPMSSLYGSDAMGGVINIIT 164
PRK13486 PRK13486
TonB-dependent receptor;
7-205 1.13e-06

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 51.18  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   7 AVSAFTDEVLADRQIEYASDLQLQVPGLSYSSNTFSGGGF--SIRGITNFLTAASGDAgveVHINGA----PLGTTSTNe 80
Cdd:PRK13486  45 SVSVISQEELQSSQYHDLAEALRSVEGVDVESGTGKTGGLeiSIRGMPASYTLILIDG---VRQGGSsdvtPNGFSAMN- 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  81 IGYLD----MSRVEVLRGPQGTLFGRNSTGGVVNMITNvPDLDAFSGSANI--------QYGADAEkmIKMMLNVP-ISD 147
Cdd:PRK13486 121 TGFMPplaaIERIEVIRGPMSTLYGSDAMGGVVNIITR-KNADKWLSSVNAglnlqesnKWGNSSQ--FNFWSSGPlVDD 197

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 291334217 148 TLGARFAISTFERDG--VTKNLNSAATDDFDNRDS--YMWRASFRWEADDDLTL----DFMHQAYD 205
Cdd:PRK13486 198 SVSLQVRGSTQQRQGssVTSLSDTAATRIPYPTESqnYNLGARLDWKASEQDVLwfdmDTTRQRYD 263
PRK13528 PRK13528
outer membrane receptor FepA; Provisional
 25-215 3.17e-06

outer membrane receptor FepA; Provisional


Pssm-ID: 237413 [Multi-domain]  Cd Length: 727  Bit Score: 49.75  E-value: 3.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  25 SDLQLQVPGLSYSSNTFSGG-----GFSIRGItnfltaasGDAGVEVHINGAPlgTTSTNEIGYL--------------- 84
Cdd:PRK13528  71 SDIIRKMPGVNLTGNSASGTrgnnrQIDIRGM--------GPENTLILIDGVP--VTSRNSVRYSwrgerdtrgdtnwvp 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  85 --DMSRVEVLRGPQGTLFGRNSTGGVVNMITNVPDlDAFSGSANIqYGADAE-------KMIKMMLNVPIS-DTLGARfa 154
Cdd:PRK13528 141 peMVERIEVIRGPAAARYGSGAAGGVVNIITKRPT-NDWHGSLSL-YTNQPEsskegatRRANFSLSGPLAgDALTMR-- 216

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 291334217 155 istferdgVTKNLNSAATDDFD-----------------NRDsymWRASFRWEADDDLTLDFmhqaydeeSARTQRQG 215
Cdd:PRK13528 217 --------LYGNLNKTDADSWDinssagtknaagregvrNKD---INGVLSWKMTPQQILDF--------EAGYSRQG 275
PRK09840 PRK09840
catecholate siderophore receptor Fiu; Provisional
 88-152 3.63e-06

catecholate siderophore receptor Fiu; Provisional


Pssm-ID: 182105 [Multi-domain]  Cd Length: 761  Bit Score: 49.42  E-value: 3.63e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 291334217  88 RVEVLRGPQGTLFGRNSTGGVVNMITNVPDLD-AFSGSANIqyGADAEKMIKMMLNVPISDTLGAR 152
Cdd:PRK09840 149 QVEVIKGPSGTDYGRSAPTGSINMISKQPRNDsGIDASASI--GSAWFRRGTLDVNQVIGDTTAVR 212
PRK10044 PRK10044
ferrichrome outer membrane transporter; Provisional
 1-116 8.19e-06

ferrichrome outer membrane transporter; Provisional


Pssm-ID: 236643 [Multi-domain]  Cd Length: 727  Bit Score: 48.22  E-value: 8.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   1 MQDVPIAVSAFTDEVLADRQIEYASDlqlqvpGLSYSSNTFSGGgfsiRGITNFLTAasgdagveVHINGAPLGTTSTNE 80
Cdd:PRK10044  76 IEKTPQSISVVTAEEMALHQPKSVKE------ALSYTPGVSVGT----RGASNTYDH--------LIIRGFAASGQSQNN 137

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 291334217  81 igYLD------------------MSRVEVLRGPQGTLFGRNSTGGVVNMITNVP 116
Cdd:PRK10044 138 --YLDglklqgnfyndavidpymLERAELMRGPVSVLYGKSNPGGLLNMVSKRP 189
PRK10003 PRK10003
ferric-rhodotorulic acid outer membrane transporter; Provisional
 2-147 1.91e-03

ferric-rhodotorulic acid outer membrane transporter; Provisional


Pssm-ID: 236640 [Multi-domain]  Cd Length: 729  Bit Score: 40.62  E-value: 1.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   2 QDVPIAVSAFTDEVLADRQIEYASDLQLQVPGLSYSSNTFSGGGFSIRG--ITNFLtaasgdagvevhINGAP------- 72
Cdd:PRK10003  76 RDIPQSVSIVSQQRMEDQQLQTLGEVMENTLGISKSQADSDRALYYSRGfqIDNYM------------VDGIPtyfesrw 143

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 291334217  73 -LGTTSTNEIGYldmSRVEVLRGPQGTLFGRNSTGGVVNMITNVPDLDAFSGSANIQYGA-DAEKMIkMMLNVPISD 147
Cdd:PRK10003 144 nLGDALSDTALF---ERVEVVRGATGLMTGTGNPSAAINMVRKHATSREFKGDVSAEYGSwNKQRYV-ADLQSPLTE 216
PRK14049 PRK14049
ferrioxamine B receptor precursor protein; Provisional
 3-197 1.98e-03

ferrioxamine B receptor precursor protein; Provisional


Pssm-ID: 172541 [Multi-domain]  Cd Length: 726  Bit Score: 40.65  E-value: 1.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   3 DVPIAVSAFTDEVLADRQIEYASDLQLQVPGLSYSSNTFSG--GGFSIRGITNFLTAASGDagvEVHINGAPLGTTSTNE 80
Cdd:PRK14049  78 ETPQSISSVTEQQLKDRNPQTLLETLAYTPGARVGAFGFDPrfDAFFVRGFDVTYTGVFRD---NLRQPGASSSIFKTEP 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217  81 IGyldMSRVEVLRGPQGTLFGRNSTGGVVNMITNVPDLDAFSgSANIQYGADAEKMIKMMLNVPISDTLGARFAISTFER 160
Cdd:PRK14049 155 YG---LEGVSILRGPSSALYGASGAGGLFNLITKRPTEEPLR-EVQVQYGTNNRYQGQFDFSGPVNETDPVYYRLTGLLR 230

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 291334217 161 DGVTKNLNSAatddfDNRdSYMWRAsFRWEADDDLTL 197
Cdd:PRK14049 231 DADTEQVGVP-----DDR-AYIAPA-FTWKPDEDTRL 260
PRK14050 PRK14050
TonB-dependent siderophore receptor;
1-116 3.78e-03

TonB-dependent siderophore receptor;


Pssm-ID: 237595 [Multi-domain]  Cd Length: 728  Bit Score: 39.78  E-value: 3.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291334217   1 MQDVPIAVSAFTDEVLADRQIEYASDLQLQ-VPGLSysSNTFSGGG----FSIRGitnFLTAASGdagveVHINGAPL-- 73
Cdd:PRK14050  76 ITEIPQSVSVVGRQEMDDRGVTNKVDEALRyTPGVL--SQPFGTDGdtdwFYIRG---FDATQTG-----VFLDGLNLfs 145

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 291334217  74 ---GTTSTNEIGyldMSRVEVLRGPQGTLFGRNSTGGVVNMITNVP 116
Cdd:PRK14050 146 ygfGGFQIDPFM---LERVEVLKGPASVLYGGSNPGGIVNMVSKRP 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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