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Conserved domains on  [gi|315454851|gb|ADU25380|]
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POU-domain protein, partial [Sus scrofa]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10441114)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0003677
PubMed:  21557080|26464018|27768937|1357790
SCOP:  4000291

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain super family cl47488
Homeodomain;
6-49 1.85e-14

Homeodomain;


The actual alignment was detected with superfamily member pfam00046:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 60.59  E-value: 1.85e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 315454851   6 ALERHFGEQNKPSSQEILRMAEELNLEKEVVRVWFCNRRQREKR 49
Cdd:pfam00046 14 ELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
6-49 1.85e-14

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 60.59  E-value: 1.85e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 315454851   6 ALERHFGEQNKPSSQEILRMAEELNLEKEVVRVWFCNRRQREKR 49
Cdd:pfam00046 14 ELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 3-48 6.95e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 51.48  E-value: 6.95e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 315454851    3 AKDALERHFGEQNKPSSQEILRMAEELNLEKEVVRVWFCNRRQREK 48
Cdd:smart00389 12 QLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 4-51 1.39e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 50.70  E-value: 1.39e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 315454851  4 KDALERHFGEQNKPSSQEILRMAEELNLEKEVVRVWFCNRRQREKRVK 51
Cdd:cd00086  12 LEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
2-49 2.05e-04

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 36.65  E-value: 2.05e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 315454851   2 AAKDALERHFGEQNKPSSQEILRMAEELNLEKEVVRVWFCNRRQREKR 49
Cdd:COG5576   61 EQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
6-49 1.85e-14

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 60.59  E-value: 1.85e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 315454851   6 ALERHFGEQNKPSSQEILRMAEELNLEKEVVRVWFCNRRQREKR 49
Cdd:pfam00046 14 ELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 3-48 6.95e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 51.48  E-value: 6.95e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 315454851    3 AKDALERHFGEQNKPSSQEILRMAEELNLEKEVVRVWFCNRRQREK 48
Cdd:smart00389 12 QLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 4-51 1.39e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 50.70  E-value: 1.39e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 315454851  4 KDALERHFGEQNKPSSQEILRMAEELNLEKEVVRVWFCNRRQREKRVK 51
Cdd:cd00086  12 LEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
2-49 2.05e-04

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 36.65  E-value: 2.05e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 315454851   2 AAKDALERHFGEQNKPSSQEILRMAEELNLEKEVVRVWFCNRRQREKR 49
Cdd:COG5576   61 EQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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