NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|323147352|gb|ADX32955|]
View 

dynein axonemal heavy chain 3, partial [Dibamus seramensis]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MT super family cl37598
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
 12-199 2.04e-32

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


The actual alignment was detected with superfamily member pfam12777:

Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 120.56  E-value: 2.04e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323147352   12 FLEGLKTYDKDNIPPAVMKRIReKFISHPDFQPAVIKNVSSACEGLCKW----VRAMEVY-DrvakvVAPKRLRLQEAEG 86
Cdd:pfam12777 155 FLDSLIKFDKEHIHEACLKAFK-PYLGDPEFDPEFIASKSTAAAGLCSWciniVRFYEVFcD-----VAPKRQALEEANA 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323147352   87 LLAVQMQKLNTKRAELKEVMDRLQALNDEFEDMNNRKIELENNIEICSQKLIRAEKLISGLGGEKDRWTEAARLLGIRYT 166
Cdd:pfam12777 229 DLAAAQEKLAAIKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQER 308

                         170       180       190
                  ....*....|....*....|....*....|...
gi 323147352  167 DLTGDILLSSGTVAYLGAFTVDYRIECQQKWLI 199
Cdd:pfam12777 309 TLCGDILLISAFISYLGFFTKKYRNELLDKFWI 341
 
Name Accession Description Interval E-value
MT pfam12777
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
 12-199 2.04e-32

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 120.56  E-value: 2.04e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323147352   12 FLEGLKTYDKDNIPPAVMKRIReKFISHPDFQPAVIKNVSSACEGLCKW----VRAMEVY-DrvakvVAPKRLRLQEAEG 86
Cdd:pfam12777 155 FLDSLIKFDKEHIHEACLKAFK-PYLGDPEFDPEFIASKSTAAAGLCSWciniVRFYEVFcD-----VAPKRQALEEANA 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323147352   87 LLAVQMQKLNTKRAELKEVMDRLQALNDEFEDMNNRKIELENNIEICSQKLIRAEKLISGLGGEKDRWTEAARLLGIRYT 166
Cdd:pfam12777 229 DLAAAQEKLAAIKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQER 308

                         170       180       190
                  ....*....|....*....|....*....|...
gi 323147352  167 DLTGDILLSSGTVAYLGAFTVDYRIECQQKWLI 199
Cdd:pfam12777 309 TLCGDILLISAFISYLGFFTKKYRNELLDKFWI 341
DYN1 COG5245
Dynein, heavy chain [Cytoskeleton];
26-183 2.07e-05

Dynein, heavy chain [Cytoskeleton];


Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 45.36  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323147352   26 PAVMKRIREKFISHPDFQPAVIKNVSSACEGLCKWVRAMEVYDRVAKVVAP-----KRL---------RLQEAEGLLAVQ 91
Cdd:COG5245  2258 LEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIPlreeeKRIdgeaflvedRLTLGKGLSSDL 2337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323147352   92 MQKLNTKRAELKEVMDRLQALNdefEDMNNRKIELENNIEicsqkliraekLISGLGGEKDRWTEAARLLGIRYTDLTGD 171
Cdd:COG5245  2338 MTFKLRRRSYYSLDILRVHGKI---ADMDTVHKDVLRSIF-----------VSEILINEDSEWGGVFSEVPKLMVELDGD 2403

                         170
                  ....*....|..
gi 323147352  172 ILLSSGTVAYLG 183
Cdd:COG5245  2404 GHPSSCLHPYIG 2415
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 59-154 8.30e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.43  E-value: 8.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323147352    59 KWVRAMEVYDRVAKVVAPKRLRLQEAEGLLAVQMQKLNTKRAELKEVMDRLQALNDEFEDMNNRKIELENNIEICSQKLI 138
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLA 312

                           90
                   ....*....|....*.
gi 323147352   139 RAEKLISGLGGEKDRW 154
Cdd:TIGR02168  313 NLERQLEELEAQLEEL 328
 
Name Accession Description Interval E-value
MT pfam12777
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
 12-199 2.04e-32

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 120.56  E-value: 2.04e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323147352   12 FLEGLKTYDKDNIPPAVMKRIReKFISHPDFQPAVIKNVSSACEGLCKW----VRAMEVY-DrvakvVAPKRLRLQEAEG 86
Cdd:pfam12777 155 FLDSLIKFDKEHIHEACLKAFK-PYLGDPEFDPEFIASKSTAAAGLCSWciniVRFYEVFcD-----VAPKRQALEEANA 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323147352   87 LLAVQMQKLNTKRAELKEVMDRLQALNDEFEDMNNRKIELENNIEICSQKLIRAEKLISGLGGEKDRWTEAARLLGIRYT 166
Cdd:pfam12777 229 DLAAAQEKLAAIKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQER 308

                         170       180       190
                  ....*....|....*....|....*....|...
gi 323147352  167 DLTGDILLSSGTVAYLGAFTVDYRIECQQKWLI 199
Cdd:pfam12777 309 TLCGDILLISAFISYLGFFTKKYRNELLDKFWI 341
DYN1 COG5245
Dynein, heavy chain [Cytoskeleton];
26-183 2.07e-05

Dynein, heavy chain [Cytoskeleton];


Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 45.36  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323147352   26 PAVMKRIREKFISHPDFQPAVIKNVSSACEGLCKWVRAMEVYDRVAKVVAP-----KRL---------RLQEAEGLLAVQ 91
Cdd:COG5245  2258 LEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIPlreeeKRIdgeaflvedRLTLGKGLSSDL 2337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323147352   92 MQKLNTKRAELKEVMDRLQALNdefEDMNNRKIELENNIEicsqkliraekLISGLGGEKDRWTEAARLLGIRYTDLTGD 171
Cdd:COG5245  2338 MTFKLRRRSYYSLDILRVHGKI---ADMDTVHKDVLRSIF-----------VSEILINEDSEWGGVFSEVPKLMVELDGD 2403

                         170
                  ....*....|..
gi 323147352  172 ILLSSGTVAYLG 183
Cdd:COG5245  2404 GHPSSCLHPYIG 2415
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 59-154 8.30e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.43  E-value: 8.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323147352    59 KWVRAMEVYDRVAKVVAPKRLRLQEAEGLLAVQMQKLNTKRAELKEVMDRLQALNDEFEDMNNRKIELENNIEICSQKLI 138
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLA 312

                           90
                   ....*....|....*.
gi 323147352   139 RAEKLISGLGGEKDRW 154
Cdd:TIGR02168  313 NLERQLEELEAQLEEL 328
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 59-161 5.17e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 37.99  E-value: 5.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323147352  59 KWVRAMEVYDRVAKVVAPKRLRLQEAEGLLAVQMQKLNTKRAELKEVMDRLQALNDEFEDMNNRKIELENNIEICSQKLI 138
Cdd:COG1196  233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRR 312

                         90       100
                 ....*....|....*....|...
gi 323147352 139 RAEKLISGLGGEKDRWTEAARLL 161
Cdd:COG1196  313 ELEERLEELEEELAELEEELEEL 335
Nuf2_DHR10-like pfam18595
Nuf2, DHR10-like domain; This domain is found at the C-terminal region of Nuf2 proteins. This ...
 91-143 7.65e-03

Nuf2, DHR10-like domain; This domain is found at the C-terminal region of Nuf2 proteins. This domain was identified as MazG related domain also designated as Designed helical repeat protein 10 (DHR10) that actually adopts a coiled-coil structure. Nuf2 is part of the Ndc80 complex, which binds to the spindle and is required for chromosome segregation and spindle checkpoint activity.


Pssm-ID: 465814 [Multi-domain]  Cd Length: 117  Bit Score: 35.25  E-value: 7.65e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 323147352   91 QMQKLNTKRAELKEVMDRLQALNDEFEDMNNRKIELENNIEICSQKLIRA-EKL 143
Cdd:pfam18595  41 LLEEIEAELAKLEEAKKKLKELRDALEEKEIELRELERREERLQRQLENAqEKL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH