|
Name |
Accession |
Description |
Interval |
E-value |
| FadR |
COG2186 |
DNA-binding transcriptional regulator, FadR family [Transcription]; |
5-228 |
4.91e-64 |
|
DNA-binding transcriptional regulator, FadR family [Transcription];
Pssm-ID: 441789 [Multi-domain] Cd Length: 232 Bit Score: 199.00 E-value: 4.91e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 5 TPIQSQRLYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRVRTPDAATLV 84
Cdd:COG2186 1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 85 APLGTLLEVRRELVRHLFDLRRMIEPQFAAEAARRITPAHLERLQEVVARQAARTARGEFPIEEDEAFHRGIVEATGNPV 164
Cdd:COG2186 81 DPLALLLALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADDGEAFAEADLAFHRAIAEASGNPL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 328452060 165 ALEVHAILAEYLRGGRDLTLQTPERAARSLEGHRAILKALAARDPAAAREGMWRHIHEVEALLF 228
Cdd:COG2186 161 LALLLESLRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLR 224
|
|
| PRK03837 |
PRK03837 |
transcriptional regulator NanR; Provisional |
5-226 |
5.22e-38 |
|
transcriptional regulator NanR; Provisional
Pssm-ID: 235166 [Multi-domain] Cd Length: 241 Bit Score: 132.84 E-value: 5.22e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 5 TPIQSQRLYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRVRTPDAATLV 84
Cdd:PRK03837 7 RPIARKKLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRPSADTII 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 85 APLG----TLLEVRRELVRHLFDLRRMIEPQFAAEAARRITPAHLERLQEVVARQAARTARGEFPIEEDEAFHRGIVEAT 160
Cdd:PRK03837 87 GQLSgmakDFLSQSPDGLAHLKQARLFFESSLARYAAEHATDEQIALLRKALERNSQSLGDNAAFIRSDMEFHRVIAEIP 166
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 328452060 161 GNPVALEVHAILAEYLRGGRDLTLQTPERAARSLEGHRAILKALAARDPAAAREGMWRHIHEVEAL 226
Cdd:PRK03837 167 GNPIFMAIHEALLDWLIEARPEVVILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLNRVSAL 232
|
|
| WHTH_GntR |
cd07377 |
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ... |
12-76 |
2.68e-24 |
|
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.
Pssm-ID: 153418 [Multi-domain] Cd Length: 66 Bit Score: 91.74 E-value: 2.68e-24
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 328452060 12 LYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRVR 76
Cdd:cd07377 2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
|
|
| GntR |
pfam00392 |
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ... |
12-75 |
7.06e-19 |
|
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.
Pssm-ID: 306822 [Multi-domain] Cd Length: 64 Bit Score: 77.65 E-value: 7.06e-19
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 328452060 12 LYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRV 75
Cdd:pfam00392 1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
|
|
| HTH_GNTR |
smart00345 |
helix_turn_helix gluconate operon transcriptional repressor; |
16-75 |
1.72e-17 |
|
helix_turn_helix gluconate operon transcriptional repressor;
Pssm-ID: 197669 [Multi-domain] Cd Length: 60 Bit Score: 73.76 E-value: 1.72e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 16 IAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRV 75
Cdd:smart00345 1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| FadR |
COG2186 |
DNA-binding transcriptional regulator, FadR family [Transcription]; |
5-228 |
4.91e-64 |
|
DNA-binding transcriptional regulator, FadR family [Transcription];
Pssm-ID: 441789 [Multi-domain] Cd Length: 232 Bit Score: 199.00 E-value: 4.91e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 5 TPIQSQRLYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRVRTPDAATLV 84
Cdd:COG2186 1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 85 APLGTLLEVRRELVRHLFDLRRMIEPQFAAEAARRITPAHLERLQEVVARQAARTARGEFPIEEDEAFHRGIVEATGNPV 164
Cdd:COG2186 81 DPLALLLALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADDGEAFAEADLAFHRAIAEASGNPL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 328452060 165 ALEVHAILAEYLRGGRDLTLQTPERAARSLEGHRAILKALAARDPAAAREGMWRHIHEVEALLF 228
Cdd:COG2186 161 LALLLESLRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLR 224
|
|
| PRK03837 |
PRK03837 |
transcriptional regulator NanR; Provisional |
5-226 |
5.22e-38 |
|
transcriptional regulator NanR; Provisional
Pssm-ID: 235166 [Multi-domain] Cd Length: 241 Bit Score: 132.84 E-value: 5.22e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 5 TPIQSQRLYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRVRTPDAATLV 84
Cdd:PRK03837 7 RPIARKKLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRPSADTII 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 85 APLG----TLLEVRRELVRHLFDLRRMIEPQFAAEAARRITPAHLERLQEVVARQAARTARGEFPIEEDEAFHRGIVEAT 160
Cdd:PRK03837 87 GQLSgmakDFLSQSPDGLAHLKQARLFFESSLARYAAEHATDEQIALLRKALERNSQSLGDNAAFIRSDMEFHRVIAEIP 166
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 328452060 161 GNPVALEVHAILAEYLRGGRDLTLQTPERAARSLEGHRAILKALAARDPAAAREGMWRHIHEVEAL 226
Cdd:PRK03837 167 GNPIFMAIHEALLDWLIEARPEVVILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLNRVSAL 232
|
|
| GntR |
COG1802 |
DNA-binding transcriptional regulator, GntR family [Transcription]; |
1-227 |
6.95e-38 |
|
DNA-binding transcriptional regulator, GntR family [Transcription];
Pssm-ID: 441407 [Multi-domain] Cd Length: 222 Bit Score: 131.58 E-value: 6.95e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 1 MDGFTPIQSQRLYQEIAERILEMIRTGRLKPGDLLpSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRVRTPDA 80
Cdd:COG1802 1 MTSPSPLRRESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 81 ATlvaplgtllevrrelVRHLFDLRRMIEPQFAAEAARRITPAHLERLQEVVARQAARTARGEFP--IEEDEAFHRGIVE 158
Cdd:COG1802 80 EE---------------IRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAayLELDREFHRALVE 144
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 328452060 159 ATGNPVALEVHAILAEYLRGGRDLTLQTPERAARSLEGHRAILKALAARDPAAAREGMWRHIHEVEALL 227
Cdd:COG1802 145 AAGNPRLAELLRRLRARLRRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERL 213
|
|
| WHTH_GntR |
cd07377 |
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ... |
12-76 |
2.68e-24 |
|
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.
Pssm-ID: 153418 [Multi-domain] Cd Length: 66 Bit Score: 91.74 E-value: 2.68e-24
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 328452060 12 LYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRVR 76
Cdd:cd07377 2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
|
|
| PRK10421 |
PRK10421 |
DNA-binding transcriptional repressor LldR; Provisional |
11-223 |
2.63e-23 |
|
DNA-binding transcriptional repressor LldR; Provisional
Pssm-ID: 236690 [Multi-domain] Cd Length: 253 Bit Score: 94.45 E-value: 2.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 11 RLYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRVRTPDAA----TLVAP 86
Cdd:PRK10421 2 RLSDEVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHETwseqNIVQP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 87 LGTLLEVRRELVRHLFDLRRMIEPQFAAEAARRITPAHLERLQ----EVVARQAARTARGefpieeDEAFHRGIVEATGN 162
Cdd:PRK10421 82 LKTLMADDPDYSFDILEARHAIEASTAWHAAMRATPGDKEKIQlcfeATLSEDPDLASQA------DVRFHLAIAEASHN 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 328452060 163 PVALEVHAILAEYLRG----GRDLTLQTPERAARSLEGHRAILKALAARDPAAAREGMWRHIHEV 223
Cdd:PRK10421 156 VVLLQTMRGFFDVLQSsvkqSRQRMYLVPPVFSQLTEQHQAVMDAILAGDAEGARKAMMAHLSFV 220
|
|
| MngR |
COG2188 |
DNA-binding transcriptional regulator, GntR family [Transcription]; |
12-178 |
2.69e-22 |
|
DNA-binding transcriptional regulator, GntR family [Transcription];
Pssm-ID: 441791 [Multi-domain] Cd Length: 238 Bit Score: 91.46 E-value: 2.69e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 12 LYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRVRtpdaatlvaplgtll 91
Cdd:COG2188 6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVA--------------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 92 evRRELVRHLFDLRRmiepqFAAEAARRITPAHLeRLQEVVARQAARTARGEFPIEEDEAFHR--GIVEATGNPVALEVH 169
Cdd:COG2188 71 --EPKIEYPLSRLTS-----FTEELRARGREPST-RVLSAERVPADEEVAEALGLPPGAPVLRieRLRLADGEPVALETS 142
|
....*....
gi 328452060 170 AILAEYLRG 178
Cdd:COG2188 143 YLPAALFPG 151
|
|
| PRK09990 |
PRK09990 |
DNA-binding transcriptional regulator GlcC; Provisional |
8-164 |
1.69e-21 |
|
DNA-binding transcriptional regulator GlcC; Provisional
Pssm-ID: 182186 [Multi-domain] Cd Length: 251 Bit Score: 89.44 E-value: 1.69e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 8 QSQRLYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRVRTPDAATLVAPL 87
Cdd:PRK09990 4 ERRPIADVVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRVQDASPL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 88 GTLLEVRRELVRHLFDLRRMIEPQFAAEAARRITPAHL----ERLQEVVARQAARTARGefPIEE---DEAFHRGIVEAT 160
Cdd:PRK09990 84 MHLFSSQPRTLYDLLEVRALLEGESARLAALRGTQADFvlitRRYEEMLAAHENNKEID--PIEHarlDHAFHLAICEAS 161
|
....
gi 328452060 161 GNPV 164
Cdd:PRK09990 162 HNPV 165
|
|
| pdhR |
PRK09464 |
pyruvate dehydrogenase complex transcriptional repressor PdhR; |
4-237 |
6.14e-21 |
|
pyruvate dehydrogenase complex transcriptional repressor PdhR;
Pssm-ID: 181879 [Multi-domain] Cd Length: 254 Bit Score: 88.15 E-value: 6.14e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 4 FTPIQSQRLYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRVRTPDAATL 83
Cdd:PRK09464 3 YSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQSF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 84 VAPLGTLLEVRRELVRHLFDLRRMIEPQFAAEAARRITPAHLERLQEVVARQAARTARGEFPIEEDE--AFHRGIVEATG 161
Cdd:PRK09464 83 SDPLVELLSDHPESQFDLLETRHALEGIAAYYAALRGTDEDFERIRECHHAIELAQQSGDLDAEANAvmQYQIAVTEAAH 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 162 NPVALEV----HAILAEYLRGGRDLTLQTPERAARSLEGHRAILKALAARDPAAAREGMWRHIHEVEALLFGSGQTPTER 237
Cdd:PRK09464 163 NVVLLHLlrcmEPMLEQNVRQNFELLYRRREMLPKVSSHRARIFEAIVAGKPEKAREASHRHLAFIEEILLDLSREESRR 242
|
|
| ARO8 |
COG1167 |
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ... |
12-140 |
2.66e-19 |
|
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis
Pssm-ID: 440781 [Multi-domain] Cd Length: 471 Bit Score: 86.04 E-value: 2.66e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 12 LYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRVRTPDAATLVAPLGTLL 91
Cdd:COG1167 13 LYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLPAPAPAPRAAAA 92
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 328452060 92 EVRRELVRHLFDLRRMIEPQFAAEAARRITPAHLERLQEVVARQAARTA 140
Cdd:COG1167 93 VAAPALRRLLEAAPGVIDLGSGAPDPDLFPLAALRRALRRALRRLPPAL 141
|
|
| GntR |
pfam00392 |
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ... |
12-75 |
7.06e-19 |
|
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.
Pssm-ID: 306822 [Multi-domain] Cd Length: 64 Bit Score: 77.65 E-value: 7.06e-19
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 328452060 12 LYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRV 75
Cdd:pfam00392 1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
|
|
| PRK11523 |
PRK11523 |
transcriptional regulator ExuR; |
8-228 |
8.35e-19 |
|
transcriptional regulator ExuR;
Pssm-ID: 183176 [Multi-domain] Cd Length: 253 Bit Score: 82.59 E-value: 8.35e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 8 QSQRLYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRVRTPDAATLVAPl 87
Cdd:PRK11523 5 EPRRLYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQQAA- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 88 GTLLEVRRELVRHLFDLRRMIEPQFAAEAARRITPAHLERLQEV--VARQAARTARGEFpieeDEAFHRGIVEATGNPV- 164
Cdd:PRK11523 84 DNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMAIqeQARGEDCFRDSEW----DLQFHVQVALATQNSAl 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 328452060 165 ALEVHAILAEYLRGG--RDLTLQTPERAARS-LEGHRAILKALAARDPAAAREGMWRHIHEVEALLF 228
Cdd:PRK11523 160 AAIVEKMWTQRSHNPywKKLHEHIDDRTVDNwCDDHDQILKALIRKDPHAAKLAMWQHLENTKQMLF 226
|
|
| HTH_GNTR |
smart00345 |
helix_turn_helix gluconate operon transcriptional repressor; |
16-75 |
1.72e-17 |
|
helix_turn_helix gluconate operon transcriptional repressor;
Pssm-ID: 197669 [Multi-domain] Cd Length: 60 Bit Score: 73.76 E-value: 1.72e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 16 IAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRV 75
Cdd:smart00345 1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
|
|
| PRK10225 |
PRK10225 |
Uxu operon transcriptional regulator; |
10-228 |
2.17e-17 |
|
Uxu operon transcriptional regulator;
Pssm-ID: 182318 [Multi-domain] Cd Length: 257 Bit Score: 78.52 E-value: 2.17e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 10 QRLYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRV-RTPDAATLVAPLG 88
Cdd:PRK10225 8 QRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVlDSSGSHNTDSPDA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 89 TLLEVRRELvrHLFDLRRMIEPQFAAEAARRITPAHLERLQEVV---ARQAARTARGEfPIEEDEAFHRGIVEATGNPVA 165
Cdd:PRK10225 88 NVCNDAGPF--ELLQARQLLESNIAEFAALQATREDIVKMRQALqleERELASSAPGS-SESGDMQFHLAIAEATHNSML 164
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 328452060 166 LEVHAILAEYlRGGRDLTLQTPERAARS------LEGHRAILKALAARDPAAAREGMWRHIHEVEALLF 228
Cdd:PRK10225 165 VELFRQSWQW-RENNPMWIQLHSHLDDSlyrkewLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLL 232
|
|
| YhcF |
COG1725 |
DNA-binding transcriptional regulator YhcF, GntR family [Transcription]; |
12-128 |
3.86e-16 |
|
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
Pssm-ID: 441331 [Multi-domain] Cd Length: 114 Bit Score: 71.75 E-value: 3.86e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 12 LYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRVrTPDAATLVAplgtll 91
Cdd:COG1725 11 IYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFV-AEDARELLE------ 83
|
90 100 110
....*....|....*....|....*....|....*...
gi 328452060 92 EVRRELVRHLFDlrrmiepQFAAEAARR-ITPAHLERL 128
Cdd:COG1725 84 ERREEFLEEALR-------ELVAEARRLgLSLEELLEL 114
|
|
| FCD |
pfam07729 |
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ... |
101-201 |
3.33e-15 |
|
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).
Pssm-ID: 429623 [Multi-domain] Cd Length: 121 Bit Score: 69.71 E-value: 3.33e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 101 LFDLRRMIEPQFAAEAARRITPAHLERLQEVVARQAARTARGEFP--IEEDEAFHRGIVEATGNPVALEVHAILAEYLRG 178
Cdd:pfam07729 2 LYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEafAEADREFHLALAEAAGNPVLARMLESLWDRLRR 81
|
90 100
....*....|....*....|...
gi 328452060 179 GRDLTLQTPERAARSLEGHRAIL 201
Cdd:pfam07729 82 LRRLLLSSPGRLRASLEEHRAIL 104
|
|
| FCD |
smart00895 |
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ... |
100-201 |
1.30e-13 |
|
This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.
Pssm-ID: 214892 [Multi-domain] Cd Length: 123 Bit Score: 65.46 E-value: 1.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 100 HLFDLRRMIEPQFAAEAARRITPAHLERLQEVVARQAARTARGEFP---IEEDEAFHRGIVEATGNPVALEVHAILAEYL 176
Cdd:smart00895 1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGDDLeefAELDREFHRALAEAAGNPVLLELLESLRARL 80
|
90 100
....*....|....*....|....*
gi 328452060 177 RGGRDLTLqtpERAARSLEGHRAIL 201
Cdd:smart00895 81 RRLRRLSL---EAARRALDEHRAIL 102
|
|
| PRK09764 |
PRK09764 |
GntR family transcriptional regulator; |
12-76 |
2.87e-13 |
|
GntR family transcriptional regulator;
Pssm-ID: 182065 [Multi-domain] Cd Length: 240 Bit Score: 67.16 E-value: 2.87e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 328452060 12 LYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRVR 76
Cdd:PRK09764 6 LYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVK 70
|
|
| PRK11402 |
PRK11402 |
transcriptional regulator PhoB; |
9-80 |
2.00e-12 |
|
transcriptional regulator PhoB;
Pssm-ID: 183118 [Multi-domain] Cd Length: 241 Bit Score: 64.47 E-value: 2.00e-12
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 328452060 9 SQRLYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRVRTPDA 80
Cdd:PRK11402 7 HQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKV 78
|
|
| PRK15481 |
PRK15481 |
transcriptional regulatory protein PtsJ; Provisional |
15-82 |
9.57e-08 |
|
transcriptional regulatory protein PtsJ; Provisional
Pssm-ID: 185378 [Multi-domain] Cd Length: 431 Bit Score: 51.97 E-value: 9.57e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 328452060 15 EIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRVRTPDAAT 82
Cdd:PRK15481 9 EIFDSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRGSPSPV 76
|
|
| PRK10079 |
PRK10079 |
phosphonate metabolism transcriptional regulator PhnF; Provisional |
6-75 |
1.93e-07 |
|
phosphonate metabolism transcriptional regulator PhnF; Provisional
Pssm-ID: 182227 [Multi-domain] Cd Length: 241 Bit Score: 50.54 E-value: 1.93e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 6 PIQSQRLYQEIAERILEMIRTgRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRV 75
Cdd:PRK10079 7 PTSYPTRYQEIAAKLEQELRQ-HYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLV 75
|
|
| PRK14999 |
PRK14999 |
histidine utilization repressor; Provisional |
12-94 |
1.96e-05 |
|
histidine utilization repressor; Provisional
Pssm-ID: 184961 [Multi-domain] Cd Length: 241 Bit Score: 44.54 E-value: 1.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 12 LYQEIAERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEGTRVRTPDAATlvaplgTLL 91
Cdd:PRK14999 13 FYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQS------ALF 86
|
...
gi 328452060 92 EVR 94
Cdd:PRK14999 87 EVR 89
|
|
| PRK04984 |
PRK04984 |
fatty acid metabolism transcriptional regulator FadR; |
18-164 |
1.35e-04 |
|
fatty acid metabolism transcriptional regulator FadR;
Pssm-ID: 179909 [Multi-domain] Cd Length: 239 Bit Score: 41.78 E-value: 1.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328452060 18 ERILEMIRTGRLKPGDLLPSERELAQRMNVSRVSVRDairVLE--AR-GILEVRQGEGTRVRTP-DAATL--VAPLGTLL 91
Cdd:PRK04984 14 EYIIESIWNNRFPPGSILPAERELSELIGVTRTTLRE---VLQrlARdGWLTIQHGKPTKVNNFwETSGLniLETLARLD 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 328452060 92 EVRR-ELVRHLFDLRRMIEPQFAAEAARRITPAHLERLQEVVARQAARTARGEFpieeDEAFHRGIVEATGNPV 164
Cdd:PRK04984 91 HDSVpQLIDNLLSARTNISAIFIRTAFRNNPEKALEVLATAEELEDTAEAFAEF----DYNLFRGLAFASGNPI 160
|
|
| HTH_36 |
pfam13730 |
Helix-turn-helix domain; |
30-65 |
5.95e-03 |
|
Helix-turn-helix domain;
Pssm-ID: 463970 [Multi-domain] Cd Length: 55 Bit Score: 34.00 E-value: 5.95e-03
10 20 30
....*....|....*....|....*....|....*.
gi 328452060 30 KPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGIL 65
Cdd:pfam13730 20 KDGGCFPSVETLAKRLGLSRRTIQRAIKELEELGYL 55
|
|
| MntR |
COG1321 |
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription]; |
14-72 |
7.98e-03 |
|
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
Pssm-ID: 440932 [Multi-domain] Cd Length: 135 Bit Score: 35.56 E-value: 7.98e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 328452060 14 QEIAERILEMIRtgRLKPGDLLPSERELAQRMNVSRVSVRDAIRVLEARGILEVRQGEG 72
Cdd:COG1321 5 SESEEDYLKAIY--ELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGG 61
|
|
| |
