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Conserved domains on  [gi|328448122|gb|AEB13838|]
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GCN5-related N-acetyltransferase [Treponema succinifaciens DSM 2489]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4491 pfam14898
Domain of unknown function (DUF4491); This family of proteins is found in bacteria. Proteins ...
 5-93 6.86e-43

Domain of unknown function (DUF4491); This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 107 amino acids in length. There is a conserved EYY sequence motif.


:

Pssm-ID: 405568  Cd Length: 90  Bit Score: 141.16  E-value: 6.86e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328448122    5 YGIIIAFASFFVIGIFHPIVIKGEYYFSEKICPVFLTAGILFCAVSIFTSGIV-SVLCALIGGACLWSIRELKEQRKRVQ 83
Cdd:pfam14898   1 TGIIIGIATFLIIGLFHPIVIKGEYYFGTRIWWVFLVAGILCIAASLFVANVLlSALLGVLGFSSLWSIGELFEQEKRVE 80

                          90
                  ....*....|
gi 328448122   84 KERFPQNKKR 93
Cdd:pfam14898  81 KGWFPKNPKR 90
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 107-246 1.10e-17

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


:

Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 76.95  E-value: 1.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328448122 107 IIIRPIQKKDNGQLSSIIRaifeefgapkensvysdkatdflfETFSENKKSEYFVAEQNGKILGGCGYFPtegLPADCA 186
Cdd:COG1246    1 MTIRPATPDDVPAILELIR------------------------PYALEEEIGEFWVAEEDGEIVGCAALHP---LDEDLA 53

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 328448122 187 EIVKFYLCPDSRGMKIRTKLFSLAEECARLAGYKKLYIESFPQfssAVSMYKKNGFTELS 246
Cdd:COG1246   54 ELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSA---AIHFYEKLGFEEID 110
 
Name Accession Description Interval E-value
DUF4491 pfam14898
Domain of unknown function (DUF4491); This family of proteins is found in bacteria. Proteins ...
 5-93 6.86e-43

Domain of unknown function (DUF4491); This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 107 amino acids in length. There is a conserved EYY sequence motif.


Pssm-ID: 405568  Cd Length: 90  Bit Score: 141.16  E-value: 6.86e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328448122    5 YGIIIAFASFFVIGIFHPIVIKGEYYFSEKICPVFLTAGILFCAVSIFTSGIV-SVLCALIGGACLWSIRELKEQRKRVQ 83
Cdd:pfam14898   1 TGIIIGIATFLIIGLFHPIVIKGEYYFGTRIWWVFLVAGILCIAASLFVANVLlSALLGVLGFSSLWSIGELFEQEKRVE 80

                          90
                  ....*....|
gi 328448122   84 KERFPQNKKR 93
Cdd:pfam14898  81 KGWFPKNPKR 90
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 107-246 1.10e-17

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 76.95  E-value: 1.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328448122 107 IIIRPIQKKDNGQLSSIIRaifeefgapkensvysdkatdflfETFSENKKSEYFVAEQNGKILGGCGYFPtegLPADCA 186
Cdd:COG1246    1 MTIRPATPDDVPAILELIR------------------------PYALEEEIGEFWVAEEDGEIVGCAALHP---LDEDLA 53

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 328448122 187 EIVKFYLCPDSRGMKIRTKLFSLAEECARLAGYKKLYIESFPQfssAVSMYKKNGFTELS 246
Cdd:COG1246   54 ELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSA---AIHFYEKLGFEEID 110
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 124-242 2.21e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 59.45  E-value: 2.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328448122  124 IRAIFEEFGAPKENSVysDKATDFLFETFSENKKSEYFVAEQNGKILGGCGYFPTEGlPADCAEIVKFYLCPDSRGMKIR 203
Cdd:pfam00583   1 LEALYELLSEEFPEPW--PDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDD-EPPVGEIEGLAVAPEYRGKGIG 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 328448122  204 TKLFSLAEECARLAGYKKLYIESFPQFSSAVSMYKKNGF 242
Cdd:pfam00583  78 TALLQALLEWARERGCERIFLEVAADNLAAIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 160-225 8.26e-08

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 48.04  E-value: 8.26e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 328448122 160 YFVAEQNGKILGGCGYFPtEGLPADCAEIVKFYLCPDSRGMKIRTKLFSLAEECARLAGYKKLYIE 225
Cdd:cd04301    1 FLVAEDDGEIVGFASLSP-DGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Name Accession Description Interval E-value
DUF4491 pfam14898
Domain of unknown function (DUF4491); This family of proteins is found in bacteria. Proteins ...
 5-93 6.86e-43

Domain of unknown function (DUF4491); This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 107 amino acids in length. There is a conserved EYY sequence motif.


Pssm-ID: 405568  Cd Length: 90  Bit Score: 141.16  E-value: 6.86e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328448122    5 YGIIIAFASFFVIGIFHPIVIKGEYYFSEKICPVFLTAGILFCAVSIFTSGIV-SVLCALIGGACLWSIRELKEQRKRVQ 83
Cdd:pfam14898   1 TGIIIGIATFLIIGLFHPIVIKGEYYFGTRIWWVFLVAGILCIAASLFVANVLlSALLGVLGFSSLWSIGELFEQEKRVE 80

                          90
                  ....*....|
gi 328448122   84 KERFPQNKKR 93
Cdd:pfam14898  81 KGWFPKNPKR 90
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 107-246 1.10e-17

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 76.95  E-value: 1.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328448122 107 IIIRPIQKKDNGQLSSIIRaifeefgapkensvysdkatdflfETFSENKKSEYFVAEQNGKILGGCGYFPtegLPADCA 186
Cdd:COG1246    1 MTIRPATPDDVPAILELIR------------------------PYALEEEIGEFWVAEEDGEIVGCAALHP---LDEDLA 53

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 328448122 187 EIVKFYLCPDSRGMKIRTKLFSLAEECARLAGYKKLYIESFPQfssAVSMYKKNGFTELS 246
Cdd:COG1246   54 ELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSA---AIHFYEKLGFEEID 110
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
106-245 9.66e-14

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 67.33  E-value: 9.66e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328448122 106 AIIIRPIQKKDNGQLSSIIRAIFEEFGAPKENSVYSDKATDFLFETFSENKkSEYFVAEQNGKILGGCGYFPTEGLPAD- 184
Cdd:COG1247    1 EMTIRPATPEDAPAIAAIYNEAIAEGTATFETEPPSEEEREAWFAAILAPG-RPVLVAEEDGEVVGFASLGPFRPRPAYr 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 328448122 185 -CAEIvKFYLCPDSRGMKIRTKLFSLAEECARLAGYKKLYIESFPQFSSAVSMYKKNGFTEL 245
Cdd:COG1247   80 gTAEE-SIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEV 140
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 124-242 2.21e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 59.45  E-value: 2.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328448122  124 IRAIFEEFGAPKENSVysDKATDFLFETFSENKKSEYFVAEQNGKILGGCGYFPTEGlPADCAEIVKFYLCPDSRGMKIR 203
Cdd:pfam00583   1 LEALYELLSEEFPEPW--PDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDD-EPPVGEIEGLAVAPEYRGKGIG 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 328448122  204 TKLFSLAEECARLAGYKKLYIESFPQFSSAVSMYKKNGF 242
Cdd:pfam00583  78 TALLQALLEWARERGCERIFLEVAADNLAAIALYEKLGF 116
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
109-248 2.43e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 60.10  E-value: 2.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328448122 109 IRPIQKKDNGQLSSIIRAIFeefgapkensvySDKATDFLFETFSENKKSEY-FVAEQNGKILGGCGYFPTE-GLPADCA 186
Cdd:COG3153    1 IRPATPEDAEAIAALLRAAF------------GPGREAELVDRLREDPAAGLsLVAEDDGEIVGHVALSPVDiDGEGPAL 68

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 328448122 187 EIVKFYLCPDSRGMKIRTKLFSLAEECARLAGYKKLYIESFPqfsSAVSMYKKNGFTELSSR 248
Cdd:COG3153   69 LLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDP---SLLPFYERFGFRPAGEL 127
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 156-244 3.50e-10

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 3.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328448122  156 KKSEYFVAEQNGKILGGCGYFPTEGlpADCAEIVKFYLCPDSRGMKIRTKLFSLAEECARLAGYKKLYIESFPQfssAVS 235
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDD--EGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNR---AAA 75


                  ....*....
gi 328448122  236 MYKKNGFTE 244
Cdd:pfam13508  76 FYEKLGFEE 84
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 182-265 4.09e-08

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 49.65  E-value: 4.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328448122 182 PADCAEIVKFYLCPDSRGMKIRTKLFSLAEECARLAGYKKLYIESFPQFSSAVSMYKKNGFTELSSRLGNSGHtaTAIHL 261
Cdd:COG0456   10 GGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGD--DALVM 87


                 ....
gi 328448122 262 IKEI 265
Cdd:COG0456   88 EKEL 91
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 160-225 8.26e-08

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 48.04  E-value: 8.26e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 328448122 160 YFVAEQNGKILGGCGYFPtEGLPADCAEIVKFYLCPDSRGMKIRTKLFSLAEECARLAGYKKLYIE 225
Cdd:cd04301    1 FLVAEDDGEIVGFASLSP-DGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 148-246 1.84e-07

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 48.90  E-value: 1.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328448122 148 LFETFSENKKSEYFVAEQNGKILGGCGYFPTEGlpaDCAEIVKFYLCPDSRGMKIRTKLFSLAEECARLAGYKKLYIESF 227
Cdd:COG0454   24 LKAMEGSLAGAEFIAVDDKGEPIGFAGLRRLDD---KVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTL 100

                         90
                 ....*....|....*....
gi 328448122 228 PQFSSAVSMYKKNGFTELS 246
Cdd:COG0454  101 DGNPAAIRFYERLGFKEIE 119
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
161-246 6.27e-04

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 39.01  E-value: 6.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328448122 161 FVAEQNGKILGGCGYFPTEGlpaDCAEIVKFYLCPDSRGMKIRTKLFSLAEECARLAGYKKLYIESfpQfSSAVSMYKKN 240
Cdd:COG2153   37 LLAYDDGELVATARLLPPGD---GEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIVLSA--Q-AHAVGFYEKL 110


                 ....*.
gi 328448122 241 GFTELS 246
Cdd:COG2153  111 GFVPVG 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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