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Conserved domains on  [gi|330251488|gb|AEC06582|]
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Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03210 super family cl33662
Resistant to P. syringae 6; Provisional
 20-1072 1.70e-84

Resistant to P. syringae 6; Provisional


The actual alignment was detected with superfamily member PLN03210:

Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 299.48  E-value: 1.70e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488   20 VFINFRGSELRYTFVYYLRTALVKNGINVFTDN-MEpkgRNQKI---LFKRIEESKIALAIFSSRYTESSWCLEELVKMK 95
Cdd:PLN03210   15 VFPSFSGEDVRITFLSHFLKELDRKLIIAFKDNeIE---RSQSLdpeLKQAIRDSRIAVVVFSKNYASSSWCLNELLEIV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488   96 ECMDAEKLVIIPIFYIVTPYTIKKQMGDFGDKF-RVLVDYVDDVTeKKWTDALKSVPLILGITYDGQSEEQLLINQIVGE 174
Cdd:PLN03210   92 RCKEELGQLVIPVFYGLDPSHVRKQTGDFGEAFeKTCQNKTEDEK-IQWKQALTDVANILGYHSQNWPNEAKMIEEIAND 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  175 VQrvikiisqgegdekNKMvctntstgsSFIPQNrnmvDPEnqiELVGLSQRLKELKEKLDLSRKETRIVGVLGMPGIGK 254
Cdd:PLN03210  171 VL--------------GKL---------NLTPSN----DFE---DFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGK 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  255 TTLVKRLYDEWKHNFQRHLHM--VNIRQKSKEYGTHS---------LERMILKELLSDTYNDITEemtYASVKDELLKKK 323
Cdd:PLN03210  221 TTIARALFSRLSRQFQSSVFIdrAFISKSMEIYSSANpddynmklhLQRAFLSEILDKKDIKIYH---LGAMEERLKHRK 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  324 VLLVLDDVSSKKQIQGLLGNLNWIRKGSRIVITTRDK--ISISQFEYTYVVPRLNITDGLKQFSFYAFEdHNCPyPGNLM 401
Cdd:PLN03210  298 VLIFIDDLDDQDVLDALAGQTQWFGSGSRIIVITKDKhfLRAHGIDHIYEVCLPSNELALEMFCRSAFK-KNSP-PDGFM 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  402 DLSTKFVDYARGNPLALKILGRELLSIDKDQWPKRLDTLAQLPIPYIQDLLRASYDDLSNQQKE-VFLVVAWFFGSGDEY 480
Cdd:PLN03210  376 ELASEVALRAGNLPLGLNVLGSYLRGRDKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNNKKDKaIFRHIACLFNGEKVN 455

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  481 YIRSLVdtedPDSADDAASEVRDFAGNLLISISSGRLEMHDLMATFAKKLCSSLSNENNYGYQMIWNHESFNAAAKNKRM 560
Cdd:PLN03210  456 DIKLLL----ANSDLDVNIGLKNLVDKSLIHVREDIVEMHSLLQEMGKEIVRAQSNEPGEREFLVDAKDICDVLEDNTGT 531

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  561 RyvnqprkkvtesemdNVMGILLDVSEMDNnMTLDSKFFSEMCNLRYLKVYNSQCSRDCDVGCKLtfPDGLKCSMENVRY 640
Cdd:PLN03210  532 K---------------KVLGITLDIDEIDE-LHIHENAFKGMRNLLFLKFYTKKWDQKKEVRWHL--PEGFDYLPPKLRL 593

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  641 LYWLQFPLKKLSKAFNPKNLIELNLPYSKITRLWKESKEISKLKWVDLSHSSELCDISGLIGAHNIRRLNLEGCIELKTL 720
Cdd:PLN03210  594 LRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVEL 673

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  721 PQEMQEMESLIYLNLGGCTRLVSLPE-FKLKSLKTLILSHCKNFEQFPVISECLEALYLQGTAIKCIPT----------- 788
Cdd:PLN03210  674 PSSIQYLNKLEDLDMSRCENLEILPTgINLKSLYRLNLSGCSRLKSFPDISTNISWLDLDETAIEEFPSnlrlenldeli 753

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  789 -------------------------------------------SIENLQKLILLDLKDCEVLVSLPDCLgNLRSLQELIL 825
Cdd:PLN03210  754 lcemkseklwervqpltplmtmlspsltrlflsdipslvelpsSIQNLHKLEHLEIENCINLETLPTGI-NLESLESLDL 832

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  826 SGCSKLKFFPELKetmKSIKILLLDGTAIKQMPILlqciqsqghsvanktlpnslsdyylpssllslclsgndieslhan 905
Cdd:PLN03210  833 SGCSRLRTFPDIS---TNISDLNLSRTGIEEVPWW--------------------------------------------- 864

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  906 ISQLYHLKWLDLKNCKKLKSVSVLPPNLKCL---DAHGCDSLEEV---GSPLAVLMVTGKIHCTY------IFTNCNKLD 973
Cdd:PLN03210  865 IEKFSNLSFLDMNGCNNLQRVSLNISKLKHLetvDFSDCGALTEAswnGSPSEVAMATDNIHSKLpstvciNFINCFNLD 944

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  974 QvaesniisftwrksqmmsDALNRYNGGFvleslVSTCFPGCEVPASFDHQAYGA------LLQTKLPRHWCDSRltgia 1047
Cdd:PLN03210  945 Q------------------EALLQQQSIF-----KQLILSGEEVPSYFTHRTTGAsltnipLLHISPCQPFFRFR----- 996

                        1130      1140
                  ....*....|....*....|....*
gi 330251488 1048 LCAVILFPDYQHQSNRFLVKCTCEF 1072
Cdd:PLN03210  997 ACAVVDSESFFIISVSFDIQVCCRF 1021
C-JID super family cl45530
C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron ...
 1012-1134 5.22e-08

C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron microscopy (cryoEM) structures of plant intracellular immune receptors containing Toll/interleukin-1 receptor (TIR, PF01582), nucleotide-binding (NB-ARC, PF00931) and leucine-rich repeat (LRR) domains (TIR-NLRs). Structurally, the C-JID core is represented by a beta-sandwich made up of 8 to 9 beta-strands. C-JID matches the so-called post LRR domain originally detected via a set of MEME motifs. The domain showed a strong distribution bias towards TIR-NLRs of dicotyledonous plant species despite broader taxonomic distribution of TIR-NLR in plant groups. Structure-function analyses of cryoEM structures suggest that C-JID domains play a role in substrate-recognition, such as binding to effector proteins from pathogens, and thus are involved in the initiation of signaling by TIR-NLR receptors. Presence of C-JID (or post-LRR) and its importance for the function of Arabidopsis TIR-NLR RPS4 that partners with RRS1 for effector recognition suggest that C-JID has additional functions.


The actual alignment was detected with superfamily member pfam20160:

Pssm-ID: 466313  Cd Length: 108  Bit Score: 52.06  E-value: 5.22e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  1012 FPGCEVPASFDHQAYGALLQTKLPRHWCDSRLTGIALCAVILFPDYQHqsnrFLVKCTCEFgtedgpCISFSSIvGDINK 1091
Cdd:pfam20160    1 LPGSQIPEWFNHQSTGSSISIKLPENWYNDNFLGFAVCAVGSLIPSLH----NFLGYIHFF------LIPLVSL-WDTSK 69

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 330251488  1092 RHVEKHGNGCipskaslrfQVTDGASEVGNCHVLK-CGFTLVYT 1134
Cdd:pfam20160   70 ANGKTPNDYG---------RIEASFEFPSDLHEIKqCGVRLIYK 104
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 20-1072 1.70e-84

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 299.48  E-value: 1.70e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488   20 VFINFRGSELRYTFVYYLRTALVKNGINVFTDN-MEpkgRNQKI---LFKRIEESKIALAIFSSRYTESSWCLEELVKMK 95
Cdd:PLN03210   15 VFPSFSGEDVRITFLSHFLKELDRKLIIAFKDNeIE---RSQSLdpeLKQAIRDSRIAVVVFSKNYASSSWCLNELLEIV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488   96 ECMDAEKLVIIPIFYIVTPYTIKKQMGDFGDKF-RVLVDYVDDVTeKKWTDALKSVPLILGITYDGQSEEQLLINQIVGE 174
Cdd:PLN03210   92 RCKEELGQLVIPVFYGLDPSHVRKQTGDFGEAFeKTCQNKTEDEK-IQWKQALTDVANILGYHSQNWPNEAKMIEEIAND 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  175 VQrvikiisqgegdekNKMvctntstgsSFIPQNrnmvDPEnqiELVGLSQRLKELKEKLDLSRKETRIVGVLGMPGIGK 254
Cdd:PLN03210  171 VL--------------GKL---------NLTPSN----DFE---DFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGK 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  255 TTLVKRLYDEWKHNFQRHLHM--VNIRQKSKEYGTHS---------LERMILKELLSDTYNDITEemtYASVKDELLKKK 323
Cdd:PLN03210  221 TTIARALFSRLSRQFQSSVFIdrAFISKSMEIYSSANpddynmklhLQRAFLSEILDKKDIKIYH---LGAMEERLKHRK 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  324 VLLVLDDVSSKKQIQGLLGNLNWIRKGSRIVITTRDK--ISISQFEYTYVVPRLNITDGLKQFSFYAFEdHNCPyPGNLM 401
Cdd:PLN03210  298 VLIFIDDLDDQDVLDALAGQTQWFGSGSRIIVITKDKhfLRAHGIDHIYEVCLPSNELALEMFCRSAFK-KNSP-PDGFM 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  402 DLSTKFVDYARGNPLALKILGRELLSIDKDQWPKRLDTLAQLPIPYIQDLLRASYDDLSNQQKE-VFLVVAWFFGSGDEY 480
Cdd:PLN03210  376 ELASEVALRAGNLPLGLNVLGSYLRGRDKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNNKKDKaIFRHIACLFNGEKVN 455

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  481 YIRSLVdtedPDSADDAASEVRDFAGNLLISISSGRLEMHDLMATFAKKLCSSLSNENNYGYQMIWNHESFNAAAKNKRM 560
Cdd:PLN03210  456 DIKLLL----ANSDLDVNIGLKNLVDKSLIHVREDIVEMHSLLQEMGKEIVRAQSNEPGEREFLVDAKDICDVLEDNTGT 531

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  561 RyvnqprkkvtesemdNVMGILLDVSEMDNnMTLDSKFFSEMCNLRYLKVYNSQCSRDCDVGCKLtfPDGLKCSMENVRY 640
Cdd:PLN03210  532 K---------------KVLGITLDIDEIDE-LHIHENAFKGMRNLLFLKFYTKKWDQKKEVRWHL--PEGFDYLPPKLRL 593

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  641 LYWLQFPLKKLSKAFNPKNLIELNLPYSKITRLWKESKEISKLKWVDLSHSSELCDISGLIGAHNIRRLNLEGCIELKTL 720
Cdd:PLN03210  594 LRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVEL 673

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  721 PQEMQEMESLIYLNLGGCTRLVSLPE-FKLKSLKTLILSHCKNFEQFPVISECLEALYLQGTAIKCIPT----------- 788
Cdd:PLN03210  674 PSSIQYLNKLEDLDMSRCENLEILPTgINLKSLYRLNLSGCSRLKSFPDISTNISWLDLDETAIEEFPSnlrlenldeli 753

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  789 -------------------------------------------SIENLQKLILLDLKDCEVLVSLPDCLgNLRSLQELIL 825
Cdd:PLN03210  754 lcemkseklwervqpltplmtmlspsltrlflsdipslvelpsSIQNLHKLEHLEIENCINLETLPTGI-NLESLESLDL 832

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  826 SGCSKLKFFPELKetmKSIKILLLDGTAIKQMPILlqciqsqghsvanktlpnslsdyylpssllslclsgndieslhan 905
Cdd:PLN03210  833 SGCSRLRTFPDIS---TNISDLNLSRTGIEEVPWW--------------------------------------------- 864

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  906 ISQLYHLKWLDLKNCKKLKSVSVLPPNLKCL---DAHGCDSLEEV---GSPLAVLMVTGKIHCTY------IFTNCNKLD 973
Cdd:PLN03210  865 IEKFSNLSFLDMNGCNNLQRVSLNISKLKHLetvDFSDCGALTEAswnGSPSEVAMATDNIHSKLpstvciNFINCFNLD 944

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  974 QvaesniisftwrksqmmsDALNRYNGGFvleslVSTCFPGCEVPASFDHQAYGA------LLQTKLPRHWCDSRltgia 1047
Cdd:PLN03210  945 Q------------------EALLQQQSIF-----KQLILSGEEVPSYFTHRTTGAsltnipLLHISPCQPFFRFR----- 996

                        1130      1140
                  ....*....|....*....|....*
gi 330251488 1048 LCAVILFPDYQHQSNRFLVKCTCEF 1072
Cdd:PLN03210  997 ACAVVDSESFFIISVSFDIQVCCRF 1021
TIR smart00255
Toll - interleukin 1 - resistance;
17-153 4.65e-39

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 142.08  E-value: 4.65e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488     17 QPQVFINFRGSE-LRYTFVYYLRTALVKNGINVFTDNMEPKGRNQKILFKRIEESKIALAIFSSRYTESSWCLEELVKMK 95
Cdd:smart00255    1 EYDVFISYSGKEdVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAAL 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488     96 ECMDAE-KLVIIPIFYIVTPYTIKKQMGDFGDKFRVLVD-YVDDVTEKKWTDALKSVPLI 153
Cdd:smart00255   81 ENALEEgGLRVIPIFYEVIPSDVRKQPGKFRKVFKKNYLkWPEDEKEQFWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 19-172 1.64e-31

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 121.32  E-value: 1.64e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488    19 QVFINFRGSELRYTFVYYLRTALVKNGINVFTD--NMEPKGRNQKILFKRIEESKIALAIFSSRYTESSWCLEELVKMKE 96
Cdd:pfam01582    2 DVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDdrDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKILE 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 330251488    97 CMDAEKLVIIPIFYIVTPYTIKKQMGDFGDKFRVLVDYVDDVTEKKWTDALKSVPLILGItyDGQSEEQLLINQIV 172
Cdd:pfam01582   82 CALDLGQKVIPIFYEVDPSDVRKQTGSFGKAFKKHKKVLTEEKVLKWRGALNEVANIWHS--KSVSDESKFWKKIA 155
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
646-940 2.22e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 2.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  646 FPLKKLSKAFNPKNLIELNLPYSKITRLWKESKEISKLKWVDLSHSSELCDISGLIGAHNIRRLNLEGCIELKTLPQEMQ 725
Cdd:COG4886    14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  726 EMESLIYLNLGGCTRLvslpeFKLKSLKTLILSHCKNFEQFPVISEC--LEALYLQGTAIKCIPTSIENLQKLILLDLKD 803
Cdd:COG4886    94 DLTNLTELDLSGNEEL-----SNLTNLESLDLSGNQLTDLPEELANLtnLKELDLSNNQLTDLPEPLGNLTNLKSLDLSN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  804 CEvLVSLPDCLGNLRSLQELILSGCsKLKFFPELKETMKSIKILLLDGtaikqmpillqciqsqghsvanktlpnslsdy 883
Cdd:COG4886   169 NQ-LTDLPEELGNLTNLKELDLSNN-QITDLPEPLGNLTNLEELDLSG-------------------------------- 214

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 330251488  884 ylpssllslclsgNDIESLHANISQLYHLKWLDLKNCkKLKSVSVLP--PNLKCLDAHG 940
Cdd:COG4886   215 -------------NQLTDLPEPLANLTNLETLDLSNN-QLTDLPELGnlTNLEELDLSN 259
C-JID pfam20160
C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron ...
 1012-1134 5.22e-08

C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron microscopy (cryoEM) structures of plant intracellular immune receptors containing Toll/interleukin-1 receptor (TIR, PF01582), nucleotide-binding (NB-ARC, PF00931) and leucine-rich repeat (LRR) domains (TIR-NLRs). Structurally, the C-JID core is represented by a beta-sandwich made up of 8 to 9 beta-strands. C-JID matches the so-called post LRR domain originally detected via a set of MEME motifs. The domain showed a strong distribution bias towards TIR-NLRs of dicotyledonous plant species despite broader taxonomic distribution of TIR-NLR in plant groups. Structure-function analyses of cryoEM structures suggest that C-JID domains play a role in substrate-recognition, such as binding to effector proteins from pathogens, and thus are involved in the initiation of signaling by TIR-NLR receptors. Presence of C-JID (or post-LRR) and its importance for the function of Arabidopsis TIR-NLR RPS4 that partners with RRS1 for effector recognition suggest that C-JID has additional functions.


Pssm-ID: 466313  Cd Length: 108  Bit Score: 52.06  E-value: 5.22e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  1012 FPGCEVPASFDHQAYGALLQTKLPRHWCDSRLTGIALCAVILFPDYQHqsnrFLVKCTCEFgtedgpCISFSSIvGDINK 1091
Cdd:pfam20160    1 LPGSQIPEWFNHQSTGSSISIKLPENWYNDNFLGFAVCAVGSLIPSLH----NFLGYIHFF------LIPLVSL-WDTSK 69

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 330251488  1092 RHVEKHGNGCipskaslrfQVTDGASEVGNCHVLK-CGFTLVYT 1134
Cdd:pfam20160   70 ANGKTPNDYG---------RIEASFEFPSDLHEIKqCGVRLIYK 104
RecA-like_Thep1 cd19482
RecA-like domain of the nucleoside-triphosphatase THEP1 family; This family represents the ...
 244-264 3.33e-03

RecA-like domain of the nucleoside-triphosphatase THEP1 family; This family represents the THEP1 family ATPase domain. It includes nucleoside-triphosphatase THEP 1 from Aquifex aeolicus (aaTHEP1) a nucleoside-phosphatase, with activity towards ATP, GTP, CTP, TTP and UTP; and which may hydrolyze nucleoside diphosphates with lower efficiency. The catalytic function of aaTHEP1 remains unclear, it may be a DNA/RNA modifying enzyme. Human THEP1 (hsTHEP1) may have a general function in many human tissues, as it is widely expressed in most examined tissues (such as in brain, heart, lymph node, skin, pancreas); it is especially highly expressed in embryonic and various tumor tissues. This family belongs to the RecA-like NTPase superfamily which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410890 [Multi-domain]  Cd Length: 164  Bit Score: 39.51  E-value: 3.33e-03
                          10        20
                  ....*....|....*....|.
gi 330251488  244 VGVLGMPGIGKTTLVKRLYDE 264
Cdd:cd19482     1 IFITGPPGVGKTTLVLKVAEL 21
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 20-1072 1.70e-84

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 299.48  E-value: 1.70e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488   20 VFINFRGSELRYTFVYYLRTALVKNGINVFTDN-MEpkgRNQKI---LFKRIEESKIALAIFSSRYTESSWCLEELVKMK 95
Cdd:PLN03210   15 VFPSFSGEDVRITFLSHFLKELDRKLIIAFKDNeIE---RSQSLdpeLKQAIRDSRIAVVVFSKNYASSSWCLNELLEIV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488   96 ECMDAEKLVIIPIFYIVTPYTIKKQMGDFGDKF-RVLVDYVDDVTeKKWTDALKSVPLILGITYDGQSEEQLLINQIVGE 174
Cdd:PLN03210   92 RCKEELGQLVIPVFYGLDPSHVRKQTGDFGEAFeKTCQNKTEDEK-IQWKQALTDVANILGYHSQNWPNEAKMIEEIAND 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  175 VQrvikiisqgegdekNKMvctntstgsSFIPQNrnmvDPEnqiELVGLSQRLKELKEKLDLSRKETRIVGVLGMPGIGK 254
Cdd:PLN03210  171 VL--------------GKL---------NLTPSN----DFE---DFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGK 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  255 TTLVKRLYDEWKHNFQRHLHM--VNIRQKSKEYGTHS---------LERMILKELLSDTYNDITEemtYASVKDELLKKK 323
Cdd:PLN03210  221 TTIARALFSRLSRQFQSSVFIdrAFISKSMEIYSSANpddynmklhLQRAFLSEILDKKDIKIYH---LGAMEERLKHRK 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  324 VLLVLDDVSSKKQIQGLLGNLNWIRKGSRIVITTRDK--ISISQFEYTYVVPRLNITDGLKQFSFYAFEdHNCPyPGNLM 401
Cdd:PLN03210  298 VLIFIDDLDDQDVLDALAGQTQWFGSGSRIIVITKDKhfLRAHGIDHIYEVCLPSNELALEMFCRSAFK-KNSP-PDGFM 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  402 DLSTKFVDYARGNPLALKILGRELLSIDKDQWPKRLDTLAQLPIPYIQDLLRASYDDLSNQQKE-VFLVVAWFFGSGDEY 480
Cdd:PLN03210  376 ELASEVALRAGNLPLGLNVLGSYLRGRDKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNNKKDKaIFRHIACLFNGEKVN 455

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  481 YIRSLVdtedPDSADDAASEVRDFAGNLLISISSGRLEMHDLMATFAKKLCSSLSNENNYGYQMIWNHESFNAAAKNKRM 560
Cdd:PLN03210  456 DIKLLL----ANSDLDVNIGLKNLVDKSLIHVREDIVEMHSLLQEMGKEIVRAQSNEPGEREFLVDAKDICDVLEDNTGT 531

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  561 RyvnqprkkvtesemdNVMGILLDVSEMDNnMTLDSKFFSEMCNLRYLKVYNSQCSRDCDVGCKLtfPDGLKCSMENVRY 640
Cdd:PLN03210  532 K---------------KVLGITLDIDEIDE-LHIHENAFKGMRNLLFLKFYTKKWDQKKEVRWHL--PEGFDYLPPKLRL 593

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  641 LYWLQFPLKKLSKAFNPKNLIELNLPYSKITRLWKESKEISKLKWVDLSHSSELCDISGLIGAHNIRRLNLEGCIELKTL 720
Cdd:PLN03210  594 LRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVEL 673

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  721 PQEMQEMESLIYLNLGGCTRLVSLPE-FKLKSLKTLILSHCKNFEQFPVISECLEALYLQGTAIKCIPT----------- 788
Cdd:PLN03210  674 PSSIQYLNKLEDLDMSRCENLEILPTgINLKSLYRLNLSGCSRLKSFPDISTNISWLDLDETAIEEFPSnlrlenldeli 753

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  789 -------------------------------------------SIENLQKLILLDLKDCEVLVSLPDCLgNLRSLQELIL 825
Cdd:PLN03210  754 lcemkseklwervqpltplmtmlspsltrlflsdipslvelpsSIQNLHKLEHLEIENCINLETLPTGI-NLESLESLDL 832

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  826 SGCSKLKFFPELKetmKSIKILLLDGTAIKQMPILlqciqsqghsvanktlpnslsdyylpssllslclsgndieslhan 905
Cdd:PLN03210  833 SGCSRLRTFPDIS---TNISDLNLSRTGIEEVPWW--------------------------------------------- 864

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  906 ISQLYHLKWLDLKNCKKLKSVSVLPPNLKCL---DAHGCDSLEEV---GSPLAVLMVTGKIHCTY------IFTNCNKLD 973
Cdd:PLN03210  865 IEKFSNLSFLDMNGCNNLQRVSLNISKLKHLetvDFSDCGALTEAswnGSPSEVAMATDNIHSKLpstvciNFINCFNLD 944

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  974 QvaesniisftwrksqmmsDALNRYNGGFvleslVSTCFPGCEVPASFDHQAYGA------LLQTKLPRHWCDSRltgia 1047
Cdd:PLN03210  945 Q------------------EALLQQQSIF-----KQLILSGEEVPSYFTHRTTGAsltnipLLHISPCQPFFRFR----- 996

                        1130      1140
                  ....*....|....*....|....*
gi 330251488 1048 LCAVILFPDYQHQSNRFLVKCTCEF 1072
Cdd:PLN03210  997 ACAVVDSESFFIISVSFDIQVCCRF 1021
TIR smart00255
Toll - interleukin 1 - resistance;
17-153 4.65e-39

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 142.08  E-value: 4.65e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488     17 QPQVFINFRGSE-LRYTFVYYLRTALVKNGINVFTDNMEPKGRNQKILFKRIEESKIALAIFSSRYTESSWCLEELVKMK 95
Cdd:smart00255    1 EYDVFISYSGKEdVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAAL 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488     96 ECMDAE-KLVIIPIFYIVTPYTIKKQMGDFGDKFRVLVD-YVDDVTEKKWTDALKSVPLI 153
Cdd:smart00255   81 ENALEEgGLRVIPIFYEVIPSDVRKQPGKFRKVFKKNYLkWPEDEKEQFWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 19-172 1.64e-31

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 121.32  E-value: 1.64e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488    19 QVFINFRGSELRYTFVYYLRTALVKNGINVFTD--NMEPKGRNQKILFKRIEESKIALAIFSSRYTESSWCLEELVKMKE 96
Cdd:pfam01582    2 DVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDdrDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKILE 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 330251488    97 CMDAEKLVIIPIFYIVTPYTIKKQMGDFGDKFRVLVDYVDDVTEKKWTDALKSVPLILGItyDGQSEEQLLINQIV 172
Cdd:pfam01582   82 CALDLGQKVIPIFYEVDPSDVRKQTGSFGKAFKKHKKVLTEEKVLKWRGALNEVANIWHS--KSVSDESKFWKKIA 155
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
646-940 2.22e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 2.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  646 FPLKKLSKAFNPKNLIELNLPYSKITRLWKESKEISKLKWVDLSHSSELCDISGLIGAHNIRRLNLEGCIELKTLPQEMQ 725
Cdd:COG4886    14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  726 EMESLIYLNLGGCTRLvslpeFKLKSLKTLILSHCKNFEQFPVISEC--LEALYLQGTAIKCIPTSIENLQKLILLDLKD 803
Cdd:COG4886    94 DLTNLTELDLSGNEEL-----SNLTNLESLDLSGNQLTDLPEELANLtnLKELDLSNNQLTDLPEPLGNLTNLKSLDLSN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  804 CEvLVSLPDCLGNLRSLQELILSGCsKLKFFPELKETMKSIKILLLDGtaikqmpillqciqsqghsvanktlpnslsdy 883
Cdd:COG4886   169 NQ-LTDLPEELGNLTNLKELDLSNN-QITDLPEPLGNLTNLEELDLSG-------------------------------- 214

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 330251488  884 ylpssllslclsgNDIESLHANISQLYHLKWLDLKNCkKLKSVSVLP--PNLKCLDAHG 940
Cdd:COG4886   215 -------------NQLTDLPEPLANLTNLETLDLSNN-QLTDLPELGnlTNLEELDLSN 259
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
517-915 6.10e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 6.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  517 LEMHDLMATFAKKLCSSLSNENNYGYQMIWNHESFNAAAKNKRMRYVNQPRKKVTESEMDNVMGILLDVSEMDNNMTLD- 595
Cdd:COG4886    24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDl 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  596 --SKFFSEMCNLRYLKVYNSQCSrdcdvgcklTFPDGLKcSMENVRYLYwLQF-PLKKLSKAF-NPKNLIELNLPYSKIT 671
Cdd:COG4886   104 sgNEELSNLTNLESLDLSGNQLT---------DLPEELA-NLTNLKELD-LSNnQLTDLPEPLgNLTNLKSLDLSNNQLT 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  672 RLWKESKEISKLKWVDLSHSselcdisgligahnirrlnlegciELKTLPQEMQEMESLIYLNLGGcTRLVSLPEF--KL 749
Cdd:COG4886   173 DLPEELGNLTNLKELDLSNN------------------------QITDLPEPLGNLTNLEELDLSG-NQLTDLPEPlaNL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  750 KSLKTLILSHCKnFEQFPVISEC--LEALYLQGTAIKCIPTSiENLQKLILLDLKDCEV----LVSLPDcLGNLRSLQEL 823
Cdd:COG4886   228 TNLETLDLSNNQ-LTDLPELGNLtnLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLtdlkLKELEL-LLGLNSLLLL 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  824 ILSGCSKLKFFPELKETMKSIKILLLDGTAIKQMPILLQCIQSQGHSVANKTLPNSLSDYYLPSSLLSLCLSGNDIESLH 903
Cdd:COG4886   305 LLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLAL 384

                         410
                  ....*....|..
gi 330251488  904 ANISQLYHLKWL 915
Cdd:COG4886   385 LLLTLLLLLLTT 396
PLN03194 PLN03194
putative disease resistance protein; Provisional
 5-114 8.30e-10

putative disease resistance protein; Provisional


Pssm-ID: 215626 [Multi-domain]  Cd Length: 187  Bit Score: 59.45  E-value: 8.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488    5 PTLRRYSMEASRQP-QVFINFRGSELRYTFVYYLRTALVKNGINVFTD--NMEPKGRnqkiLFKRIE----ESKIALAIF 77
Cdd:PLN03194   13 LFLHYPSSSSSAKPcDVFINHRGIDTKRTIATLLYDHLSRLNLRPFLDnkNMKPGDK----LFDKINsairNCKVGVAVF 88

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 330251488   78 SSRYTESSWCLEELVKMkecMDAEKLViIPIFYIVTP 114
Cdd:PLN03194   89 SPRYCESYFCLHELALI---MESKKRV-IPIFCDVKP 121
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 20-110 6.46e-09

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 55.01  E-value: 6.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488    20 VFINFRGSELryTFVYYLRTALVKNGINVFTD--NMEPKGRNQKILFKRIEESKIALAIFSSRYTESSWCLEELVKMKEC 97
Cdd:pfam13676    1 VFISYAGEDR--AWAEWLADALEAAGYRVWLDrwDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALAD 78

                           90
                   ....*....|...
gi 330251488    98 MDAEKlVIIPIFY 110
Cdd:pfam13676   79 PEGRK-RLIPVRL 90
NB-ARC pfam00931
NB-ARC domain;
227-458 6.82e-09

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 57.77  E-value: 6.82e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488   227 LKELKEKLDLSrKETRIVGVLGMPGIGKTTLVKRLY---DEWKHNFQRHlHMVNIrqkSKEYGTHSLERMILKELLsdTY 303
Cdd:pfam00931    5 VEKVIGKLSEK-DEPGIVGIHGMGGVGKTTLAAQIFndfDEVEGHFDSV-AWVVV---SKTFTISTLQQTILQNLG--LS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488   304 NDITEEMTyasvkdelLKKKVLLVLDDVSSKKQI--------QGLLGNLNWIRK----GSRIVITTRDKI---SISQFEY 368
Cdd:pfam00931   78 EDDWDNKE--------EGELARKIRRALLTKRFLlvlddvwdEEDWDKIGIPLPdrenGCRVLLTTRSEEvagRVGGPSD 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488   369 TYVVPRLNITDGLKQFSFYAFEDHNCPYPgNLMDLSTKFVDYARGNPLALKILGrELLSIDK--DQWPKRLDTL--AQLP 444
Cdd:pfam00931  150 PHEVELLEPDEAWELFENKVFPKTLGECE-LLEDVAKEIVEKCRGLPLALKVLG-GLLSCKKtvEEWKHVYDVLqsELKS 227

                          250
                   ....*....|....*...
gi 330251488   445 IPYIQDLLRA----SYDD 458
Cdd:pfam00931  228 NSYSLNSVRSilqlSYEN 245
C-JID pfam20160
C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron ...
 1012-1134 5.22e-08

C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron microscopy (cryoEM) structures of plant intracellular immune receptors containing Toll/interleukin-1 receptor (TIR, PF01582), nucleotide-binding (NB-ARC, PF00931) and leucine-rich repeat (LRR) domains (TIR-NLRs). Structurally, the C-JID core is represented by a beta-sandwich made up of 8 to 9 beta-strands. C-JID matches the so-called post LRR domain originally detected via a set of MEME motifs. The domain showed a strong distribution bias towards TIR-NLRs of dicotyledonous plant species despite broader taxonomic distribution of TIR-NLR in plant groups. Structure-function analyses of cryoEM structures suggest that C-JID domains play a role in substrate-recognition, such as binding to effector proteins from pathogens, and thus are involved in the initiation of signaling by TIR-NLR receptors. Presence of C-JID (or post-LRR) and its importance for the function of Arabidopsis TIR-NLR RPS4 that partners with RRS1 for effector recognition suggest that C-JID has additional functions.


Pssm-ID: 466313  Cd Length: 108  Bit Score: 52.06  E-value: 5.22e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  1012 FPGCEVPASFDHQAYGALLQTKLPRHWCDSRLTGIALCAVILFPDYQHqsnrFLVKCTCEFgtedgpCISFSSIvGDINK 1091
Cdd:pfam20160    1 LPGSQIPEWFNHQSTGSSISIKLPENWYNDNFLGFAVCAVGSLIPSLH----NFLGYIHFF------LIPLVSL-WDTSK 69

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 330251488  1092 RHVEKHGNGCipskaslrfQVTDGASEVGNCHVLK-CGFTLVYT 1134
Cdd:pfam20160   70 ANGKTPNDYG---------RIEASFEFPSDLHEIKqCGVRLIYK 104
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
748-954 2.53e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 2.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  748 KLKSLKTLILSHCKNFEQFpvisECLEALYLQGTAIKCIPTSIENLQKLILLDLKDCEvLVSLPDCLGNLRSLQELILSG 827
Cdd:COG4886    94 DLTNLTELDLSGNEELSNL----TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQ-LTDLPEPLGNLTNLKSLDLSN 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  828 csklkffpelketmksikillldgtaikqmpillqciqsqghsvanktlpnslsdyylpssllslclsgNDIESLHANIS 907
Cdd:COG4886   169 ---------------------------------------------------------------------NQLTDLPEELG 179

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 330251488  908 QLYHLKWLDLKNCKklksVSVLP------PNLKCLDAHGCDsLEEVGSPLAVL 954
Cdd:COG4886   180 NLTNLKELDLSNNQ----ITDLPeplgnlTNLEELDLSGNQ-LTDLPEPLANL 227
PRK15386 PRK15386
type III secretion effector GogB;
700-846 8.54e-05

type III secretion effector GogB;


Pssm-ID: 237954 [Multi-domain]  Cd Length: 426  Bit Score: 46.40  E-value: 8.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330251488  700 LIGAHNIRRLNLEGCiELKTLPQEMqemESLIYLNLGGCTRLVSLPEFKLKSLKTLILSHCKnfeQFPVISECLEALYLQ 779
Cdd:PRK15386   48 IEEARASGRLYIKDC-DIESLPVLP---NELTEITIENCNNLTTLPGSIPEGLEKLTVCHCP---EISGLPESVRSLEIK 120

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 330251488  780 GTAIKCIPTSIENLQKLILLDLKDcEVLVSLPDCLGNlrSLQELILSGCSKLKFFPELKETMKSIKI 846
Cdd:PRK15386  121 GSATDSIKNVPNGLTSLSINSYNP-ENQARIDNLISP--SLKTLSLTGCSNIILPEKLPESLQSITL 184
LRR_3 pfam07725
Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the ...
 659-678 8.55e-04

Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the pfam00560 model.


Pssm-ID: 429621 [Multi-domain]  Cd Length: 20  Bit Score: 37.70  E-value: 8.55e-04
                           10        20
                   ....*....|....*....|
gi 330251488   659 NLIELNLPYSKITRLWKESK 678
Cdd:pfam07725    1 NLVELNMPYSKLEKLWEGVK 20
RecA-like_Thep1 cd19482
RecA-like domain of the nucleoside-triphosphatase THEP1 family; This family represents the ...
 244-264 3.33e-03

RecA-like domain of the nucleoside-triphosphatase THEP1 family; This family represents the THEP1 family ATPase domain. It includes nucleoside-triphosphatase THEP 1 from Aquifex aeolicus (aaTHEP1) a nucleoside-phosphatase, with activity towards ATP, GTP, CTP, TTP and UTP; and which may hydrolyze nucleoside diphosphates with lower efficiency. The catalytic function of aaTHEP1 remains unclear, it may be a DNA/RNA modifying enzyme. Human THEP1 (hsTHEP1) may have a general function in many human tissues, as it is widely expressed in most examined tissues (such as in brain, heart, lymph node, skin, pancreas); it is especially highly expressed in embryonic and various tumor tissues. This family belongs to the RecA-like NTPase superfamily which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410890 [Multi-domain]  Cd Length: 164  Bit Score: 39.51  E-value: 3.33e-03
                          10        20
                  ....*....|....*....|.
gi 330251488  244 VGVLGMPGIGKTTLVKRLYDE 264
Cdd:cd19482     1 IFITGPPGVGKTTLVLKVAEL 21
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 219-265 5.22e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 39.02  E-value: 5.22e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 330251488   219 ELVGLSQRLKELKEKLD-LSRKETRIVGVLGMPGIGKTTLVKRLYDEW 265
Cdd:pfam13191    1 RLVGREEELEQLLDALDrVRSGRPPSVLLTGEAGTGKTTLLRELLRAL 48
PRK13695 PRK13695
NTPase;
244-264 5.86e-03

NTPase;


Pssm-ID: 237475  Cd Length: 174  Bit Score: 39.13  E-value: 5.86e-03
                          10        20
                  ....*....|....*....|.
gi 330251488  244 VGVLGMPGIGKTTLVKRLYDE 264
Cdd:PRK13695    3 IGITGPPGVGKTTLVLKIAEL 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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