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Conserved domains on  [gi|332196140|gb|AEE34261|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 212-525 3.94e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 140.16  E-value: 3.94e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 212 QEFSAHDGSILAMKFSPDGKYIASAGEDCVVRVWSITEEERTDTYEVAE--VDSGVYFGMNQRsqieplkinnektekks 289
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgpVRDVAASADGTY----------------- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 290 sFLRKSSDSTCVVLPPTifsiSEKPLHEFKGHIGEILDLSWSEKG-YLLSSSVDETVRLWRVGCDECLRTFT-HNNFVTC 367
Cdd:cd00200   66 -LASGSSDKTIRLWDLE----TGECVRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNS 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 368 VAFNPvDDNYFISGSIDGKVRIWDVTRCRVV-DYTDIRDIVTAVCYRPDAKGAVIGSMTGNCRFYhifenQLQMDQEINV 446
Cdd:cd00200  141 VAFSP-DGTFVASSSQDGTIKLWDLRTGKCVaTLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW-----DLSTGKCLGT 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 447 HGKKkvaSKRISGLQYLPsdsDSDKVMVTSADSQIRI--ICGEDVICKLKASSLRTTSASFISDGKHIISTSEDSYINVW 524
Cdd:cd00200  215 LRGH---ENGVNSVAFSP---DGYLLASGSEDGTIRVwdLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288


                 .
gi 332196140 525 S 525
Cdd:cd00200  289 D 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 212-525 3.94e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.16  E-value: 3.94e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 212 QEFSAHDGSILAMKFSPDGKYIASAGEDCVVRVWSITEEERTDTYEVAE--VDSGVYFGMNQRsqieplkinnektekks 289
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgpVRDVAASADGTY----------------- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 290 sFLRKSSDSTCVVLPPTifsiSEKPLHEFKGHIGEILDLSWSEKG-YLLSSSVDETVRLWRVGCDECLRTFT-HNNFVTC 367
Cdd:cd00200   66 -LASGSSDKTIRLWDLE----TGECVRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNS 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 368 VAFNPvDDNYFISGSIDGKVRIWDVTRCRVV-DYTDIRDIVTAVCYRPDAKGAVIGSMTGNCRFYhifenQLQMDQEINV 446
Cdd:cd00200  141 VAFSP-DGTFVASSSQDGTIKLWDLRTGKCVaTLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW-----DLSTGKCLGT 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 447 HGKKkvaSKRISGLQYLPsdsDSDKVMVTSADSQIRI--ICGEDVICKLKASSLRTTSASFISDGKHIISTSEDSYINVW 524
Cdd:cd00200  215 LRGH---ENGVNSVAFSP---DGYLLASGSEDGTIRVwdLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288


                 .
gi 332196140 525 S 525
Cdd:cd00200  289 D 289
WD40 COG2319
WD40 repeat [General function prediction only];
212-525 2.87e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.74  E-value: 2.87e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 212 QEFSAHDGSILAMKFSPDGKYIASAGEDCVVRVWSITEEERTDTYEV--AEVDSgVYFgmnqrsqieplkinnektekks 289
Cdd:COG2319  114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGhsGAVTS-VAF---------------------- 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 290 sflrkSSDSTcvvlppTIFSISE------------KPLHEFKGHIGEILDLSWSEKG-YLLSSSVDETVRLWRVGCDECL 356
Cdd:COG2319  171 -----SPDGK------LLASGSDdgtvrlwdlatgKLLRTLTGHTGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLL 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 357 RTFT-HNNFVTCVAFNPvDDNYFISGSIDGKVRIWDV-TRCRVVDYTDIRDIVTAVCYRPDAKGAVIGSMTGNCRFYhif 434
Cdd:COG2319  240 RTLTgHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLaTGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW--- 315

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 435 enQLQMDQEINVHgkkKVASKRISGLQYLPsdsDSDKVMVTSADSQIRI--ICGEDVICKLKASSLRTTSASFISDGKHI 512
Cdd:COG2319  316 --DLATGKLLRTL---TGHTGAVRSVAFSP---DGKTLASGSDDGTVRLwdLATGELLRTLTGHTGAVTSVAFSPDGRTL 387

                        330
                 ....*....|...
gi 332196140 513 ISTSEDSYINVWS 525
Cdd:COG2319  388 ASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 354-391 1.95e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 1.95e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 332196140   354 ECLRTFT-HNNFVTCVAFNPvDDNYFISGSIDGKVRIWD 391
Cdd:smart00320   3 ELLKTLKgHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
354-391 8.51e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 8.51e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 332196140  354 ECLRTFT-HNNFVTCVAFNPvDDNYFISGSIDGKVRIWD 391
Cdd:pfam00400   2 KLLKTLEgHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 314-392 1.33e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 1.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 314 PLHEFKGHIGEILDLS----WSEkgYLLSSSVDETVRLWRV-GCDECLRTFT--------HNNFVTCVAFNPVddNYFI- 379
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQfnpcFSE--ILASGSEDLTIRVWEIpHNDESVKEIKdpqcilkgHKKKISIIDWNPM--NYYIm 141

                         90
                 ....*....|....
gi 332196140 380 -SGSIDGKVRIWDV 392
Cdd:PTZ00420 142 cSSGFDSFVNIWDI 155
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 212-525 3.94e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.16  E-value: 3.94e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 212 QEFSAHDGSILAMKFSPDGKYIASAGEDCVVRVWSITEEERTDTYEVAE--VDSGVYFGMNQRsqieplkinnektekks 289
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgpVRDVAASADGTY----------------- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 290 sFLRKSSDSTCVVLPPTifsiSEKPLHEFKGHIGEILDLSWSEKG-YLLSSSVDETVRLWRVGCDECLRTFT-HNNFVTC 367
Cdd:cd00200   66 -LASGSSDKTIRLWDLE----TGECVRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNS 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 368 VAFNPvDDNYFISGSIDGKVRIWDVTRCRVV-DYTDIRDIVTAVCYRPDAKGAVIGSMTGNCRFYhifenQLQMDQEINV 446
Cdd:cd00200  141 VAFSP-DGTFVASSSQDGTIKLWDLRTGKCVaTLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW-----DLSTGKCLGT 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 447 HGKKkvaSKRISGLQYLPsdsDSDKVMVTSADSQIRI--ICGEDVICKLKASSLRTTSASFISDGKHIISTSEDSYINVW 524
Cdd:cd00200  215 LRGH---ENGVNSVAFSP---DGYLLASGSEDGTIRVwdLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288


                 .
gi 332196140 525 S 525
Cdd:cd00200  289 D 289
WD40 COG2319
WD40 repeat [General function prediction only];
212-525 2.87e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.74  E-value: 2.87e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 212 QEFSAHDGSILAMKFSPDGKYIASAGEDCVVRVWSITEEERTDTYEV--AEVDSgVYFgmnqrsqieplkinnektekks 289
Cdd:COG2319  114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGhsGAVTS-VAF---------------------- 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 290 sflrkSSDSTcvvlppTIFSISE------------KPLHEFKGHIGEILDLSWSEKG-YLLSSSVDETVRLWRVGCDECL 356
Cdd:COG2319  171 -----SPDGK------LLASGSDdgtvrlwdlatgKLLRTLTGHTGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLL 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 357 RTFT-HNNFVTCVAFNPvDDNYFISGSIDGKVRIWDV-TRCRVVDYTDIRDIVTAVCYRPDAKGAVIGSMTGNCRFYhif 434
Cdd:COG2319  240 RTLTgHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLaTGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW--- 315

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 435 enQLQMDQEINVHgkkKVASKRISGLQYLPsdsDSDKVMVTSADSQIRI--ICGEDVICKLKASSLRTTSASFISDGKHI 512
Cdd:COG2319  316 --DLATGKLLRTL---TGHTGAVRSVAFSP---DGKTLASGSDDGTVRLwdLATGELLRTLTGHTGAVTSVAFSPDGRTL 387

                        330
                 ....*....|...
gi 332196140 513 ISTSEDSYINVWS 525
Cdd:COG2319  388 ASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
212-557 2.76e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.62  E-value: 2.76e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 212 QEFSAHDGSILAMKFSPDGKYIASAGEDCVVRVWSITeeertdtyevaevdsgvyfgmnqrsqieplkinnektekkssf 291
Cdd:COG2319   72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA------------------------------------------- 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 292 lrkssdstcvvlpptifsiSEKPLHEFKGHIGEILDLSWSEKG-YLLSSSVDETVRLWRVGCDECLRTFT-HNNFVTCVA 369
Cdd:COG2319  109 -------------------TGLLLRTLTGHTGAVRSVAFSPDGkTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVA 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 370 FNPvDDNYFISGSIDGKVRIWDVTRCRVVD-YTDIRDIVTAVCYRPDAKGAVIGSMTGNCRFYHIFENQLQmdQEINVHg 448
Cdd:COG2319  170 FSP-DGKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGH- 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 449 kkkvaSKRISGLQYLPsdsDSDKVMVTSADSQIRI--ICGEDVICKLKASSLRTTSASFISDGKHIISTSEDSYINVWSY 526
Cdd:COG2319  246 -----SGSVRSVAFSP---DGRLLASGSADGTVRLwdLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317

                        330       340       350
                 ....*....|....*....|....*....|.
gi 332196140 527 sqlpskkpysETPKSIRSYEGFLSHNASVAI 557
Cdd:COG2319  318 ----------ATGKLLRTLTGHTGAVRSVAF 338
WD40 COG2319
WD40 repeat [General function prediction only];
212-393 2.77e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 2.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 212 QEFSAHDGSILAMKFSPDGKYIASAGEDCVVRVWSIT--EEERTDTYEVAEVDSGVYfgmnqrsqieplkinnektekks 289
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAtgELLRTLTGHSGGVNSVAF----------------------- 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 290 sflrkSSDSTcvvlppTIFSISE------------KPLHEFKGHIGEILDLSWSEKG-YLLSSSVDETVRLWRVGCDECL 356
Cdd:COG2319  297 -----SPDGK------LLASGSDdgtvrlwdlatgKLLRTLTGHTGAVRSVAFSPDGkTLASGSDDGTVRLWDLATGELL 365

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 332196140 357 RTFT-HNNFVTCVAFNPvDDNYFISGSIDGKVRIWDVT 393
Cdd:COG2319  366 RTLTgHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 205-423 5.67e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.49  E-value: 5.67e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 205 LSSMCIDQEFSAHDGSILAMKFSPDGKYIASAGEDCVVRVWSITEEERTDTYEVAEVDsgvyfgmnqrsqieplkINNEK 284
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW-----------------VNSVA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 285 TEKKSSFLRKSSDSTCVvlppTIFSI-SEKPLHEFKGHIGEILDLSWSEKGY-LLSSSVDETVRLWRVGCDECLRTFT-H 361
Cdd:cd00200  143 FSPDGTFVASSSQDGTI----KLWDLrTGKCVATLTGHTGEVNSVAFSPDGEkLLSSSSDGTIKLWDLSTGKCLGTLRgH 218

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 332196140 362 NNFVTCVAFNPvDDNYFISGSIDGKVRIWDVTRCRVVdyTDIR---DIVTAVCYRPDAKGAVIGS 423
Cdd:cd00200  219 ENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECV--QTLSghtNSVTSLAWSPDGKRLASGS 280
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 314-638 2.32e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 2.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 314 PLHEFKGHIGEILDLSWSEKG-YLLSSSVDETVRLWRVGCDECLRTFT-HNNFVTCVAFNPvDDNYFISGSIDGKVRIWD 391
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGkLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASA-DGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 392 V-TRCRVVDYTDIRDIVTAVCYRPDAKGAVIGSMTGNCRFYHIFENQLQmdQEINVHgkkkvaSKRISGLQYLPSDSdsd 470
Cdd:cd00200   80 LeTGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL--TTLRGH------TDWVNSVAFSPDGT--- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 471 kvMVTSA--DSQIRIICGEDVICK--LKASSLRTTSASFISDGKHIISTSEDSYINVWSYSqlpskkpyseTPKSIRSYE 546
Cdd:cd00200  149 --FVASSsqDGTIKLWDLRTGKCVatLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----------TGKCLGTLR 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 547 GflsHNASV-AIPWLRQGRRdgLSECITDLDMKIPKVDCFSPMK---GSTTWpeekLEDVAMSNRGKlkllrsawqphlw 622
Cdd:cd00200  217 G---HENGVnSVAFSPDGYL--LASGSEDGTIRVWDLRTGECVQtlsGHTNS----VTSLAWSPDGK------------- 274

                        330
                 ....*....|....*.
gi 332196140 623 glVIVTATWDGRIRVF 638
Cdd:cd00200  275 --RLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
315-565 3.87e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.48  E-value: 3.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 315 LHEFKGHIGEILDLSWSEKG-YLLSSSVDETVRLWRVGCDECLRTFT-HNNFVTCVAFNPvDDNYFISGSIDGKVRIWDV 392
Cdd:COG2319   29 LLLLLGLAAAVASLAASPDGaRLAAGAGDLTLLLLDAAAGALLATLLgHTAAVLSVAFSP-DGRLLASASADGTVRLWDL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 393 -TRCRVVDYTDIRDIVTAVCYRPDAKGAVIGSMTGNCRFYHIFENQLQmdQEINVHgkkkvaSKRISGLQYLPsdsDSDK 471
Cdd:COG2319  108 aTGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL--RTLTGH------SGAVTSVAFSP---DGKL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 472 VMVTSADSQIRI--ICGEDVICKLKASSLRTTSASFISDGKHIISTSEDSYINVWSysqlpskkpySETPKSIRSYEGFL 549
Cdd:COG2319  177 LASGSDDGTVRLwdLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD----------LATGKLLRTLTGHS 246

                        250
                 ....*....|....*.
gi 332196140 550 SHNASVAipWLRQGRR 565
Cdd:COG2319  247 GSVRSVA--FSPDGRL 260
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 354-391 1.95e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 1.95e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 332196140   354 ECLRTFT-HNNFVTCVAFNPvDDNYFISGSIDGKVRIWD 391
Cdd:smart00320   3 ELLKTLKgHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 212-246 6.76e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 6.76e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 332196140   212 QEFSAHDGSILAMKFSPDGKYIASAGEDCVVRVWS 246
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
354-391 8.51e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 8.51e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 332196140  354 ECLRTFT-HNNFVTCVAFNPvDDNYFISGSIDGKVRIWD 391
Cdd:pfam00400   2 KLLKTLEgHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
212-246 6.53e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 6.53e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 332196140  212 QEFSAHDGSILAMKFSPDGKYIASAGEDCVVRVWS 246
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 210-246 2.55e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 2.55e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 332196140 210 IDQEFSAHDGSILAMKFSPDGKYIASAGEDCVVRVWS 246
Cdd:cd00200  253 CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 311-348 2.82e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.82e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 332196140   311 SEKPLHEFKGHIGEILDLSWSEKG-YLLSSSVDETVRLW 348
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
313-348 1.31e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.31e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 332196140  313 KPLHEFKGHIGEILDLSWSEKG-YLLSSSVDETVRLW 348
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 314-392 1.33e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 1.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332196140 314 PLHEFKGHIGEILDLS----WSEkgYLLSSSVDETVRLWRV-GCDECLRTFT--------HNNFVTCVAFNPVddNYFI- 379
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQfnpcFSE--ILASGSEDLTIRVWEIpHNDESVKEIKdpqcilkgHKKKISIIDWNPM--NYYIm 141

                         90
                 ....*....|....
gi 332196140 380 -SGSIDGKVRIWDV 392
Cdd:PTZ00420 142 cSSGFDSFVNIWDI 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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