NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|332661274|gb|AEE86674|]
View 

AAA-type ATPase family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
ATAD3_N pfam12037
ATPase family AAA domain-containing protein 3, N-terminal; This is the conserved N-terminal ...
54-317 1.20e-123

ATPase family AAA domain-containing protein 3, N-terminal; This is the conserved N-terminal domain of ATPase family AAA domain-containing protein 3 (ATAD3) which is involved in dimerization and interacts with the inner surface of the outer mitochondrial membrane. This domain is found associated with the AAA ATPase domain (pfam00004). ATAD3 is essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organizm and cellular level. It may also play an important role in mitochondrial protein synthesis.


:

Pssm-ID: 463442 [Multi-domain]  Cd Length: 264  Bit Score: 366.23  E-value: 1.20e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274   54 SSSKSKAEPDEPK--GSGFDPEALERAAKALRDINSSPHSKQVFDLMRKQEKTRLAELTAETSHYEAIQAHNDIGRQQKL 131
Cdd:pfam12037   5 SDKDPKKSNDKPRtaYSGFDPEALERAAKAARELESSPHAKKALELMKKQEQTRQAELQAKIKEYEAAQEQLKIERQRVE 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  132 AEDQRNLLQTQAQTKAQNLRYEDELARKRQQTDHEAQRHHNVELVKMQEASSIRKEKAKIateeqiQAQHRQTEKERAEL 211
Cdd:pfam12037  85 YEERRKTLQEETKQKQQRAQYQDELARKRYQDQLEAQRRRNEELLRKQEESVAKQEAMRI------QAQRRQTEEHEAEL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  212 ERETIRVKAMAEAEGRAHEAKLTEEQNRRLLMERINGEREKWLAAINTMFSHIEGGFRTLLTDRNKLIMTVGGATALAAG 291
Cdd:pfam12037 159 RRETERAKAEAEAEARAKEERENEDLNLEQLREKANEERETVLESINTAGSHIGGGLRALLTDWDKLVAAVGGLTALAAG 238
                         250       260
                  ....*....|....*....|....*.
gi 332661274  292 VYTTREGARVTWGYINRMLGQPSLIR 317
Cdd:pfam12037 239 VYTAKEGTGVAWRYIEARLGKPSLVR 264
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
361-510 1.01e-86

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd19512:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 150  Bit Score: 267.08  E-value: 1.01e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 361 LKKRIERLARATANTKSHQAPFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAPLGSQAVTKIHQIFDWAKKSN 440
Cdd:cd19512    1 LEARVRDIAIATRNTKKNKGLYRNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAIHKVFDWANTSR 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 441 KGLLLFIDEADAFLCERNSTYMSEAQRSALNALLFRTGDQSRDIVLVLATNRRGDLDSAVTDRIDEVIEF 510
Cdd:cd19512   81 RGLLLFVDEADAFLRKRSTEKISEDLRAALNAFLYRTGEQSNKFMLVLASNQPEQFDWAINDRIDEMVEF 150
 
Name Accession Description Interval E-value
ATAD3_N pfam12037
ATPase family AAA domain-containing protein 3, N-terminal; This is the conserved N-terminal ...
54-317 1.20e-123

ATPase family AAA domain-containing protein 3, N-terminal; This is the conserved N-terminal domain of ATPase family AAA domain-containing protein 3 (ATAD3) which is involved in dimerization and interacts with the inner surface of the outer mitochondrial membrane. This domain is found associated with the AAA ATPase domain (pfam00004). ATAD3 is essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organizm and cellular level. It may also play an important role in mitochondrial protein synthesis.


Pssm-ID: 463442 [Multi-domain]  Cd Length: 264  Bit Score: 366.23  E-value: 1.20e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274   54 SSSKSKAEPDEPK--GSGFDPEALERAAKALRDINSSPHSKQVFDLMRKQEKTRLAELTAETSHYEAIQAHNDIGRQQKL 131
Cdd:pfam12037   5 SDKDPKKSNDKPRtaYSGFDPEALERAAKAARELESSPHAKKALELMKKQEQTRQAELQAKIKEYEAAQEQLKIERQRVE 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  132 AEDQRNLLQTQAQTKAQNLRYEDELARKRQQTDHEAQRHHNVELVKMQEASSIRKEKAKIateeqiQAQHRQTEKERAEL 211
Cdd:pfam12037  85 YEERRKTLQEETKQKQQRAQYQDELARKRYQDQLEAQRRRNEELLRKQEESVAKQEAMRI------QAQRRQTEEHEAEL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  212 ERETIRVKAMAEAEGRAHEAKLTEEQNRRLLMERINGEREKWLAAINTMFSHIEGGFRTLLTDRNKLIMTVGGATALAAG 291
Cdd:pfam12037 159 RRETERAKAEAEAEARAKEERENEDLNLEQLREKANEERETVLESINTAGSHIGGGLRALLTDWDKLVAAVGGLTALAAG 238
                         250       260
                  ....*....|....*....|....*.
gi 332661274  292 VYTTREGARVTWGYINRMLGQPSLIR 317
Cdd:pfam12037 239 VYTAKEGTGVAWRYIEARLGKPSLVR 264
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
361-510 1.01e-86

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 267.08  E-value: 1.01e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 361 LKKRIERLARATANTKSHQAPFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAPLGSQAVTKIHQIFDWAKKSN 440
Cdd:cd19512    1 LEARVRDIAIATRNTKKNKGLYRNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAIHKVFDWANTSR 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 441 KGLLLFIDEADAFLCERNSTYMSEAQRSALNALLFRTGDQSRDIVLVLATNRRGDLDSAVTDRIDEVIEF 510
Cdd:cd19512   81 RGLLLFVDEADAFLRKRSTEKISEDLRAALNAFLYRTGEQSNKFMLVLASNQPEQFDWAINDRIDEMVEF 150
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
197-584 5.69e-36

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 139.66  E-value: 5.69e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 197 IQAQHRQTEKERAELERETIRVKAMAEAEGRAHEAKLTEEQNRRLLMERINGEREKWLAAINTMFSHIEGGFRTLLTDRN 276
Cdd:COG0464    1 LAELLALAVALALALLLLDDAALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 277 KLIMTVGGATALAAGVYTTREGARVTWGYINRMLGQPSLIRESSMRRFPWTGSVSQFKNRISGAAAASAAEGKKPLDNVI 356
Cdd:COG0464   81 LLAALLSALELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELLELREAILDDLG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 357 LHTSLKKRIERLARA-TANTKSHQA----PFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAplgSQAV----T 427
Cdd:COG0464  161 GLEEVKEELRELVALpLKRPELREEyglpPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLV---SKYVgeteK 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 428 KIHQIFDWAKKSNKGLLlFIDEADAFLCERNSTyMSEAQRSALNALLFRTGDQSRDIVLVLATNRRGDLDSAVTDRIDEV 507
Cdd:COG0464  238 NLREVFDKARGLAPCVL-FIDEADALAGKRGEV-GDGVGRRVVNTLLTEMEELRSDVVVIAATNRPDLLDPALLRRFDEI 315
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 332661274 508 IEFPLPGEEERFKllnlylnkylkmgdnnedtkpkwshLFKKLSQKITVEEDLTdkvISEAAKKTEGFSGREIAKLV 584
Cdd:COG0464  316 IFFPLPDAEERLE-------------------------IFRIHLRKRPLDEDVD---LEELAEATEGLSGADIRNVV 364
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
352-618 3.59e-34

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 130.39  E-value: 3.59e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 352 LDNVILHTSLKKRIERLA---RATANTKSH-QAPFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVapLGS---Q 424
Cdd:COG1223    1 LDDVVGQEEAKKKLKLIIkelRRRENLRKFgLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSL--IGSylgE 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 425 AVTKIHQIFDWAKksNKGLLLFIDEADAFLCER-NSTYMSEAQRsALNALLFRTGDQSRDIVLVLATNRRGDLDSAVTDR 503
Cdd:COG1223   79 TARNLRKLFDFAR--RAPCVIFFDEFDAIAKDRgDQNDVGEVKR-VVNALLQELDGLPSGSVVIAATNHPELLDSALWRR 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 504 IDEVIEFPLPGEEERfkllnlylnkylkmgdnnedtkpkwSHLFKKLSQKITVEEDLTDKVIseaAKKTEGFSGREIAKL 583
Cdd:COG1223  156 FDEVIEFPLPDKEER-------------------------KEILELNLKKFPLPFELDLKKL---AKKLEGLSGADIEKV 207
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 332661274 584 VAGVqagvygRADCVLD--SQLFKEIVEYKVEEHHRR 618
Cdd:COG1223  208 LKTA------LKKAILEdrEKVTKEDLEEALKQRKER 238
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
385-512 1.49e-30

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 116.15  E-value: 1.49e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  385 MMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAPLG-SQAVTKIHQIFDWAKKSNKGlLLFIDEADAFLCERNSTYMS 463
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYvGESEKRLRELFEAAKKLAPC-VIFIDEIDALAGSRGSGGDS 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 332661274  464 EAQRsALNALLFRTGDQSRD---IVLVLATNRRGDLDSAVTDRIDEVIEFPL 512
Cdd:pfam00004  80 ESRR-VVNQLLTELDGFTSSnskVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
381-584 3.37e-16

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 82.26  E-value: 3.37e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  381 PFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDV-APLGSQAVTKIHQIFDWAKKSNKGlLLFIDEADAFLCERNS 459
Cdd:TIGR01243 486 PPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEIlSKWVGESEKAIREIFRKARQAAPA-IIFFDEIDAIAPARGA 564
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  460 TYMSEAQRSALNALLFRTG--DQSRDIVLVLATNRRGDLDSAV--TDRIDEVIEFPLPGEEERFKllnlylnkylkmgdn 535
Cdd:TIGR01243 565 RFDTSVTDRIVNQLLTEMDgiQELSNVVVIAATNRPDILDPALlrPGRFDRLILVPPPDEEARKE--------------- 629
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 332661274  536 nedtkpkwshLFKKLSQKITVEEDLTdkvISEAAKKTEGFSGREIAKLV 584
Cdd:TIGR01243 630 ----------IFKIHTRSMPLAEDVD---LEELAEMTEGYTGADIEAVC 665
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
381-518 3.61e-13

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 71.72  E-value: 3.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 381 PFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAP--LGsQAVTKIHQIFDWAKKsNKGLLLFIDEADAFLCERN 458
Cdd:PTZ00454 178 PPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQkyLG-EGPRMVRDVFRLARE-NAPSIIFIDEVDSIATKRF 255
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 332661274 459 STYMS---EAQRSALNALLFRTG-DQSRDIVLVLATNRRGDLDSAV--TDRIDEVIEFPLPGEEER 518
Cdd:PTZ00454 256 DAQTGadrEVQRILLELLNQMDGfDQTTNVKVIMATNRADTLDPALlrPGRLDRKIEFPLPDRRQK 321
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
381-513 3.39e-12

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 64.32  E-value: 3.39e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274   381 PFRNMMFYGPPGTGKTMVAREIARKSG------------------LDYAMMTGGDVAPLGSQAVTKIHQIFDWAKKSNKG 442
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGppgggviyidgedileevLDQLLLIIVGGKKASGSGELRLRLALALARKLKPD 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 332661274   443 lLLFIDEADAFLCERNSTYMSEAQRSALNALLfrtgDQSRDIVLVLATNRRGDLDSAVT-DRIDEVIEFPLP 513
Cdd:smart00382  81 -VLILDEITSLLDAEQEALLLLLEELRLLLLL----KSEKNLTVILTTNDEKDLGPALLrRRFDRRIVLLLI 147
PTZ00121 PTZ00121
MAEBL; Provisional
79-252 1.13e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.52  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274   79 AKALRDINSSPHSKQVFDLMRKQEKTRLAELTAETSHYEAIQAHNDIGRQ--QKLAEDQRNLLQTQAQTKAQNLRYEDEL 156
Cdd:PTZ00121 1539 AKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKaeEARIEEVMKLYEEEKKMKAEEAKKAEEA 1618
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  157 ARKRQQTDHEAQRHHNVELVKMQEASSIRKEKAKIATEEQIQAQHRQTEKERAELERETIRVKAMAEAEGRAHEAKLTEE 236
Cdd:PTZ00121 1619 KIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEA 1698
                         170
                  ....*....|....*.
gi 332661274  237 QNRRLLMERINGEREK 252
Cdd:PTZ00121 1699 EEAKKAEELKKKEAEE 1714
 
Name Accession Description Interval E-value
ATAD3_N pfam12037
ATPase family AAA domain-containing protein 3, N-terminal; This is the conserved N-terminal ...
54-317 1.20e-123

ATPase family AAA domain-containing protein 3, N-terminal; This is the conserved N-terminal domain of ATPase family AAA domain-containing protein 3 (ATAD3) which is involved in dimerization and interacts with the inner surface of the outer mitochondrial membrane. This domain is found associated with the AAA ATPase domain (pfam00004). ATAD3 is essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organizm and cellular level. It may also play an important role in mitochondrial protein synthesis.


Pssm-ID: 463442 [Multi-domain]  Cd Length: 264  Bit Score: 366.23  E-value: 1.20e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274   54 SSSKSKAEPDEPK--GSGFDPEALERAAKALRDINSSPHSKQVFDLMRKQEKTRLAELTAETSHYEAIQAHNDIGRQQKL 131
Cdd:pfam12037   5 SDKDPKKSNDKPRtaYSGFDPEALERAAKAARELESSPHAKKALELMKKQEQTRQAELQAKIKEYEAAQEQLKIERQRVE 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  132 AEDQRNLLQTQAQTKAQNLRYEDELARKRQQTDHEAQRHHNVELVKMQEASSIRKEKAKIateeqiQAQHRQTEKERAEL 211
Cdd:pfam12037  85 YEERRKTLQEETKQKQQRAQYQDELARKRYQDQLEAQRRRNEELLRKQEESVAKQEAMRI------QAQRRQTEEHEAEL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  212 ERETIRVKAMAEAEGRAHEAKLTEEQNRRLLMERINGEREKWLAAINTMFSHIEGGFRTLLTDRNKLIMTVGGATALAAG 291
Cdd:pfam12037 159 RRETERAKAEAEAEARAKEERENEDLNLEQLREKANEERETVLESINTAGSHIGGGLRALLTDWDKLVAAVGGLTALAAG 238
                         250       260
                  ....*....|....*....|....*.
gi 332661274  292 VYTTREGARVTWGYINRMLGQPSLIR 317
Cdd:pfam12037 239 VYTAKEGTGVAWRYIEARLGKPSLVR 264
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
361-510 1.01e-86

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 267.08  E-value: 1.01e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 361 LKKRIERLARATANTKSHQAPFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAPLGSQAVTKIHQIFDWAKKSN 440
Cdd:cd19512    1 LEARVRDIAIATRNTKKNKGLYRNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAIHKVFDWANTSR 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 441 KGLLLFIDEADAFLCERNSTYMSEAQRSALNALLFRTGDQSRDIVLVLATNRRGDLDSAVTDRIDEVIEF 510
Cdd:cd19512   81 RGLLLFVDEADAFLRKRSTEKISEDLRAALNAFLYRTGEQSNKFMLVLASNQPEQFDWAINDRIDEMVEF 150
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
197-584 5.69e-36

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 139.66  E-value: 5.69e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 197 IQAQHRQTEKERAELERETIRVKAMAEAEGRAHEAKLTEEQNRRLLMERINGEREKWLAAINTMFSHIEGGFRTLLTDRN 276
Cdd:COG0464    1 LAELLALAVALALALLLLDDAALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 277 KLIMTVGGATALAAGVYTTREGARVTWGYINRMLGQPSLIRESSMRRFPWTGSVSQFKNRISGAAAASAAEGKKPLDNVI 356
Cdd:COG0464   81 LLAALLSALELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELLELREAILDDLG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 357 LHTSLKKRIERLARA-TANTKSHQA----PFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAplgSQAV----T 427
Cdd:COG0464  161 GLEEVKEELRELVALpLKRPELREEyglpPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLV---SKYVgeteK 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 428 KIHQIFDWAKKSNKGLLlFIDEADAFLCERNSTyMSEAQRSALNALLFRTGDQSRDIVLVLATNRRGDLDSAVTDRIDEV 507
Cdd:COG0464  238 NLREVFDKARGLAPCVL-FIDEADALAGKRGEV-GDGVGRRVVNTLLTEMEELRSDVVVIAATNRPDLLDPALLRRFDEI 315
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 332661274 508 IEFPLPGEEERFKllnlylnkylkmgdnnedtkpkwshLFKKLSQKITVEEDLTdkvISEAAKKTEGFSGREIAKLV 584
Cdd:COG0464  316 IFFPLPDAEERLE-------------------------IFRIHLRKRPLDEDVD---LEELAEATEGLSGADIRNVV 364
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
352-618 3.59e-34

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 130.39  E-value: 3.59e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 352 LDNVILHTSLKKRIERLA---RATANTKSH-QAPFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVapLGS---Q 424
Cdd:COG1223    1 LDDVVGQEEAKKKLKLIIkelRRRENLRKFgLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSL--IGSylgE 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 425 AVTKIHQIFDWAKksNKGLLLFIDEADAFLCER-NSTYMSEAQRsALNALLFRTGDQSRDIVLVLATNRRGDLDSAVTDR 503
Cdd:COG1223   79 TARNLRKLFDFAR--RAPCVIFFDEFDAIAKDRgDQNDVGEVKR-VVNALLQELDGLPSGSVVIAATNHPELLDSALWRR 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 504 IDEVIEFPLPGEEERfkllnlylnkylkmgdnnedtkpkwSHLFKKLSQKITVEEDLTDKVIseaAKKTEGFSGREIAKL 583
Cdd:COG1223  156 FDEVIEFPLPDKEER-------------------------KEILELNLKKFPLPFELDLKKL---AKKLEGLSGADIEKV 207
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 332661274 584 VAGVqagvygRADCVLD--SQLFKEIVEYKVEEHHRR 618
Cdd:COG1223  208 LKTA------LKKAILEdrEKVTKEDLEEALKQRKER 238
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
360-510 6.59e-32

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 121.24  E-value: 6.59e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 360 SLKKRIERLARATANTKSHQAPFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVA-PLGSQAVTKIHQIFDWAKK 438
Cdd:cd19481    4 SLREAVEAPRRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLsKYVGESEKNLRKIFERARR 83
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 332661274 439 SnKGLLLFIDEADAFLCERNSTYMSEAQRSALNALLFRT-GDQSRD-IVLVLATNRRGDLDSAVTD--RIDEVIEF 510
Cdd:cd19481   84 L-APCILFIDEIDAIGRKRDSSGESGELRRVLNQLLTELdGVNSRSkVLVIAATNRPDLLDPALLRpgRFDEVIEF 158
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
385-512 1.49e-30

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 116.15  E-value: 1.49e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  385 MMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAPLG-SQAVTKIHQIFDWAKKSNKGlLLFIDEADAFLCERNSTYMS 463
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYvGESEKRLRELFEAAKKLAPC-VIFIDEIDALAGSRGSGGDS 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 332661274  464 EAQRsALNALLFRTGDQSRD---IVLVLATNRRGDLDSAVTDRIDEVIEFPL 512
Cdd:pfam00004  80 ESRR-VVNQLLTELDGFTSSnskVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
386-589 1.13e-25

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 108.17  E-value: 1.13e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 386 MFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAP--LGSQAvTKIHQIFDWAKKSNKGlLLFIDEADAFLCERNSTYMS 463
Cdd:COG1222  116 LLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSkyIGEGA-RNVREVFELAREKAPS-IIFIDEIDAIAARRTDDGTS 193
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 464 -EAQRSaLNALL-FRTGDQSR-DIVLVLATNRRGDLDSAVT--DRIDEVIEFPLPGEEERfkllnlylnkylkmgdnned 538
Cdd:COG1222  194 gEVQRT-VNQLLaELDGFESRgDVLIIAATNRPDLLDPALLrpGRFDRVIEVPLPDEEAR-------------------- 252
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 332661274 539 tkpkwSHLFKKLSQKITVEEDLTdkvISEAAKKTEGFSGREIAKLV--AGVQA 589
Cdd:COG1222  253 -----EEILKIHLRDMPLADDVD---LDKLAKLTEGFSGADLKAIVteAGMFA 297
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
379-512 6.14e-17

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 78.34  E-value: 6.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 379 QAPFRNMMFYGPPGTGKTMVAREIARKSG--------LDYAMMTGGDVapLGSQAVTKIHQIFDWAKKSNKGLLLFIDEA 450
Cdd:cd00009   16 LPPPKNLLLYGPPGTGKTTLARAIANELFrpgapflyLNASDLLEGLV--VAELFGHFLVRLLFELAEKAKPGVLFIDEI 93
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 332661274 451 DAFlcernSTYMSEAQRSALNALLFrTGDQSRDIVLVLATNRR--GDLDSAVTDRIDEVIEFPL 512
Cdd:cd00009   94 DSL-----SRGAQNALLRVLETLND-LRIDRENVRVIGATNRPllGDLDRALYDRLDIRIVIPL 151
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
381-584 3.37e-16

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 82.26  E-value: 3.37e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  381 PFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDV-APLGSQAVTKIHQIFDWAKKSNKGlLLFIDEADAFLCERNS 459
Cdd:TIGR01243 486 PPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEIlSKWVGESEKAIREIFRKARQAAPA-IIFFDEIDAIAPARGA 564
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  460 TYMSEAQRSALNALLFRTG--DQSRDIVLVLATNRRGDLDSAV--TDRIDEVIEFPLPGEEERFKllnlylnkylkmgdn 535
Cdd:TIGR01243 565 RFDTSVTDRIVNQLLTEMDgiQELSNVVVIAATNRPDILDPALlrPGRFDRLILVPPPDEEARKE--------------- 629
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 332661274  536 nedtkpkwshLFKKLSQKITVEEDLTdkvISEAAKKTEGFSGREIAKLV 584
Cdd:TIGR01243 630 ----------IFKIHTRSMPLAEDVD---LEELAEMTEGYTGADIEAVC 665
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
380-510 1.45e-15

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 74.64  E-value: 1.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 380 APFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDV--APLGsQAVTKIHQIFDWAkKSNKGLLLFIDEADAfLCER 457
Cdd:cd19503   32 KPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIvsKYLG-ESEKNLREIFEEA-RSHAPSIIFIDEIDA-LAPK 108
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 332661274 458 NSTYMSEAQRSALNALL-FRTGDQSRDIVLVL-ATNRRGDLDSAV--TDRIDEVIEF 510
Cdd:cd19503  109 REEDQREVERRVVAQLLtLMDGMSSRGKVVVIaATNRPDAIDPALrrPGRFDREVEI 165
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
381-508 2.95e-14

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 70.78  E-value: 2.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 381 PFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGgdvAPLGSQAVTK----IHQIFDWAKKsNKGLLLFIDEADAFLCE 456
Cdd:cd19511   26 PPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKG---PELFSKYVGEseraVREIFQKARQ-AAPCIIFFDEIDSLAPR 101
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 332661274 457 RNSTYMSEAQRSALNALLFR-TGDQSRDIVLVL-ATNRRGDLDSAV--TDRIDEVI 508
Cdd:cd19511  102 RGQSDSSGVTDRVVSQLLTElDGIESLKGVVVIaATNRPDMIDPALlrPGRLDKLI 157
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
352-504 1.03e-13

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 69.38  E-value: 1.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 352 LDNVIlhTSLKKRIE---RLARATANTKSHQAPfRNMMFYGPPGTGKTMVAREIARKSG-----LDYAMMTG---GDvap 420
Cdd:cd19520    5 LDEVI--TELKELVIlplQRPELFDNSRLLQPP-KGVLLYGPPGCGKTMLAKATAKEAGarfinLQVSSLTDkwyGE--- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 421 lgSQAVTKihQIFDWAKKSNKGlLLFIDEADAFLCERNST-YMSEAQRSALNALL---FRTGDQSRDIVLVlATNRRGDL 496
Cdd:cd19520   79 --SQKLVA--AVFSLASKLQPS-IIFIDEIDSFLRQRSSTdHEATAMMKAEFMSLwdgLSTDGNCRVIVMG-ATNRPQDL 152

                 ....*...
gi 332661274 497 DSAVTDRI 504
Cdd:cd19520  153 DEAILRRM 160
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
380-510 1.19e-13

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 69.29  E-value: 1.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 380 APFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTggdvaplGSQAVTK--------IHQIFDWAkKSNKGLLLFIDEAD 451
Cdd:cd19502   35 EPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVV-------GSELVQKyigegarlVRELFEMA-REKAPSIIFIDEID 106
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 332661274 452 AFLCER---NSTYMSEAQRSALNALLFRTG-DQSRDIVLVLATNRRGDLDSAV--TDRIDEVIEF 510
Cdd:cd19502  107 AIGAKRfdsGTGGDREVQRTMLELLNQLDGfDPRGNIKVIMATNRPDILDPALlrPGRFDRKIEF 171
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
380-503 3.04e-13

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 67.76  E-value: 3.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 380 APFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVA--PLGsQAVTKIHQIFDWAKKsNKGLLLFIDEADAFLCER 457
Cdd:cd19509   30 GPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVskWVG-ESEKIVRALFALARE-LQPSIIFIDEIDSLLSER 107
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 332661274 458 NSTyMSEAQRSALNALLFR---TGDQSRDIVLVL-ATNRRGDLDSAVTDR 503
Cdd:cd19509  108 GSG-EHEASRRVKTEFLVQmdgVLNKPEDRVLVLgATNRPWELDEAFLRR 156
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
381-518 3.61e-13

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 71.72  E-value: 3.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 381 PFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAP--LGsQAVTKIHQIFDWAKKsNKGLLLFIDEADAFLCERN 458
Cdd:PTZ00454 178 PPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQkyLG-EGPRMVRDVFRLARE-NAPSIIFIDEVDSIATKRF 255
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 332661274 459 STYMS---EAQRSALNALLFRTG-DQSRDIVLVLATNRRGDLDSAV--TDRIDEVIEFPLPGEEER 518
Cdd:PTZ00454 256 DAQTGadrEVQRILLELLNQMDGfDQTTNVKVIMATNRADTLDPALlrPGRLDRKIEFPLPDRRQK 321
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
381-511 1.81e-12

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 65.92  E-value: 1.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 381 PFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDV-APLGSQAVTKIHQIFDWAKKsNKGLLLFIDEADAFLCERNS 459
Cdd:cd19519   33 PPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEImSKLAGESESNLRKAFEEAEK-NAPAIIFIDEIDAIAPKREK 111
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 332661274 460 TYmSEAQRSALNALL-FRTGDQSRDIVLVL-ATNRRGDLDSAVT--DRIDEVIEFP 511
Cdd:cd19519  112 TH-GEVERRIVSQLLtLMDGLKQRAHVIVMaATNRPNSIDPALRrfGRFDREIDIG 166
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
381-513 3.39e-12

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 64.32  E-value: 3.39e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274   381 PFRNMMFYGPPGTGKTMVAREIARKSG------------------LDYAMMTGGDVAPLGSQAVTKIHQIFDWAKKSNKG 442
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGppgggviyidgedileevLDQLLLIIVGGKKASGSGELRLRLALALARKLKPD 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 332661274   443 lLLFIDEADAFLCERNSTYMSEAQRSALNALLfrtgDQSRDIVLVLATNRRGDLDSAVT-DRIDEVIEFPLP 513
Cdd:smart00382  81 -VLILDEITSLLDAEQEALLLLLEELRLLLLL----KSEKNLTVILTTNDEKDLGPALLrRRFDRRIVLLLI 147
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
383-500 3.48e-12

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 64.95  E-value: 3.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 383 RNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAP----LGSQavtKIHQIFDWAKKsNKGLLLFIDEADAFLCERN 458
Cdd:cd19501   38 KGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEmfvgVGAS---RVRDLFEQAKK-NAPCIVFIDEIDAVGRKRG 113
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 332661274 459 STYM--SEAQRSALNALL-----FRTGDQsrdIVLVLATNRRGDLDSAV 500
Cdd:cd19501  114 AGLGggHDEREQTLNQLLvemdgFESNTG---VIVIAATNRPDVLDPAL 159
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
381-508 5.76e-12

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 64.07  E-value: 5.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 381 PFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAPLG-SQAVTKIHQIFDWAKKSNKgLLLFIDEADAFLCERNS 459
Cdd:cd19528   26 PSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWfGESEANVRDIFDKARAAAP-CVLFFDELDSIAKARGG 104
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 332661274 460 TY--MSEAQRSALNALLFRTG--DQSRDIVLVLATNRRGDLDSAVT--DRIDEVI 508
Cdd:cd19528  105 NIgdAGGAADRVINQILTEMDgmNTKKNVFIIGATNRPDIIDPAILrpGRLDQLI 159
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
388-590 6.94e-12

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 67.55  E-value: 6.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 388 YGPPGTGKTMVAREIARKSGLDYAMMTggdvaplGSQAVTK--------IHQIFDWAKKsNKGLLLFIDEADAFLCERNS 459
Cdd:PRK03992 171 YGPPGTGKTLLAKAVAHETNATFIRVV-------GSELVQKfigegarlVRELFELARE-KAPSIIFIDEIDAIAAKRTD 242
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 460 TYMS---EAQRSALNALLFRTGDQSR-DIVLVLATNRRGDLDSAV--TDRIDEVIEFPLPGEEERfkllnlylnkylkmg 533
Cdd:PRK03992 243 SGTSgdrEVQRTLMQLLAEMDGFDPRgNVKIIAATNRIDILDPAIlrPGRFDRIIEVPLPDEEGR--------------- 307
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 332661274 534 dnnedtkpkwSHLFKKLSQKITVEEDLTdkvISEAAKKTEGFSGREIAKLVagVQAG 590
Cdd:PRK03992 308 ----------LEILKIHTRKMNLADDVD---LEELAELTEGASGADLKAIC--TEAG 349
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
381-508 3.95e-11

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 61.92  E-value: 3.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 381 PFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAP-LGSQAVTKIHQIFDWAKKSNKGlLLFIDEADAFLCERNS 459
Cdd:cd19522   32 PWKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSkYRGESEKLVRLLFEMARFYAPT-TIFIDEIDSICSRRGT 110
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 332661274 460 TYMSEAQRSALNALLFR--------TGDQSRDIVLVL-ATNRRGDLDSAVTDRIDEVI 508
Cdd:cd19522  111 SEEHEASRRVKSELLVQmdgvggasENDDPSKMVMVLaATNFPWDIDEALRRRLEKRI 168
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
375-508 5.33e-11

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 61.36  E-value: 5.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 375 TKSHQAPFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAPLGSQAVTK-IHQIFDWAKKSNKgLLLFIDEADAF 453
Cdd:cd19529   20 KRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKaIREIFRKARQVAP-CVIFFDEIDSI 98
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 332661274 454 LCERNSTYMSEAQRSALNALLFRTG--DQSRDIVLVLATNRRGDLDSAV--TDRIDEVI 508
Cdd:cd19529   99 APRRGTTGDSGVTERVVNQLLTELDglEEMNGVVVIAATNRPDIIDPALlrAGRFDRLI 157
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
381-508 6.43e-11

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 61.42  E-value: 6.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 381 PFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAP--LG-SQAVTKihQIFDWAKKsNKGLLLFIDEADAfLCER 457
Cdd:cd19521   39 PWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSkwMGeSEKLVK--QLFAMARE-NKPSIIFIDEVDS-LCGT 114
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 332661274 458 NSTYMSEAQRSALNALLFR---TGDQSRDIVLVLATNRRGDLDSAVTDRIDEVI 508
Cdd:cd19521  115 RGEGESEASRRIKTELLVQmngVGNDSQGVLVLGATNIPWQLDSAIRRRFEKRI 168
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
381-516 1.05e-10

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 64.02  E-value: 1.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 381 PFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMtggdvapLGSQAVTK--------IHQIFDWAKKsNKGLLLFIDEADA 452
Cdd:PTZ00361 216 PPKGVILYGPPGTGKTLLAKAVANETSATFLRV-------VGSELIQKylgdgpklVRELFRVAEE-NAPSIVFIDEIDA 287
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 453 FLCER---NSTYMSEAQRSALNALLFRTGDQSR-DIVLVLATNRRGDLDSAVT--DRIDEVIEFPLPGEE 516
Cdd:PTZ00361 288 IGTKRydaTSGGEKEIQRTMLELLNQLDGFDSRgDVKVIMATNRIESLDPALIrpGRIDRKIEFPNPDEK 357
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
379-504 1.51e-10

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 60.25  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 379 QAPFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGgdvAPLGSQAVTK----IHQIFDWAKKSNKGlLLFIDEADAFL 454
Cdd:cd19524   30 RAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISA---ASLTSKYVGEgeklVRALFAVARELQPS-IIFIDEVDSLL 105
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 332661274 455 CERNSTYMSEAQRSALNALLFRTGDQSR--DIVLVL-ATNRRGDLDSAVTDRI 504
Cdd:cd19524  106 SERSEGEHEASRRLKTEFLIEFDGVQSNgdDRVLVMgATNRPQELDDAVLRRF 158
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
381-518 1.03e-09

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 61.46  E-value: 1.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  381 PFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDV-APLGSQAVTKIHQIFDWAKKsNKGLLLFIDEADAFLCERNS 459
Cdd:TIGR01243 211 PPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEImSKYYGESEERLREIFKEAEE-NAPSIIFIDEIDAIAPKREE 289
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 332661274  460 TYMSEAQRSALNALLFRTGDQSRDIVLVL-ATNRRGDLDSAV--TDRIDEVIEFPLPGEEER 518
Cdd:TIGR01243 290 VTGEVEKRVVAQLLTLMDGLKGRGRVIVIgATNRPDALDPALrrPGRFDREIVIRVPDKRAR 351
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
383-584 1.35e-09

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 61.20  E-value: 1.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 383 RNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGD-VAPLGSQAVTKIHQIFDWAKKSNKgLLLFIDEADAFLCERNSTY 461
Cdd:PRK10733 186 KGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDfVEMFVGVGASRVRDMFEQAKKAAP-CIIFIDEIDAVGRQRGAGL 264
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 462 MS--EAQRSALNALLFRTG--DQSRDIVLVLATNRRGDLDSAV--TDRIDEVIEFPLPGEEERfkllnlylnkylkmgdn 535
Cdd:PRK10733 265 GGghDEREQTLNQMLVEMDgfEGNEGIIVIAATNRPDVLDPALlrPGRFDRQVVVGLPDVRGR----------------- 327
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 332661274 536 nedtkpkwSHLFKKLSQKITVEEDLTDKVIseaAKKTEGFSGREIAKLV 584
Cdd:PRK10733 328 --------EQILKVHMRRVPLAPDIDAAII---ARGTPGFSGADLANLV 365
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
379-504 5.20e-09

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 56.15  E-value: 5.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 379 QAPFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGgdvAPLGSQAVTK----IHQIFDWAKKSNKGlLLFIDEADAFL 454
Cdd:cd19525   52 RGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISA---SSLTSKWVGEgekmVRALFSVARCKQPA-VIFIDEIDSLL 127
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 332661274 455 CERNSTYMSEAQRSALNALLFRTG--DQSRDIVLVL-ATNRRGDLDSAVTDRI 504
Cdd:cd19525  128 SQRGEGEHESSRRIKTEFLVQLDGatTSSEDRILVVgATNRPQEIDEAARRRL 180
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
376-500 7.16e-09

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 55.59  E-value: 7.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 376 KSHQAPFRNMMFYGPPGTGKTMVAREIARKSGLD-----YAMMTGGDV-APLGSQAVTKIHQIFDWAKKsNKGLLLFIDE 449
Cdd:cd19517   28 KFKITPPRGVLFHGPPGTGKTLMARALAAECSKGgqkvsFFMRKGADClSKWVGEAERQLRLLFEEAYR-MQPSIIFFDE 106
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 332661274 450 ADAFLCERNSTyMSEAQRSALNALL-FRTGDQSR-DIVLVLATNRRGDLDSAV 500
Cdd:cd19517  107 IDGLAPVRSSK-QEQIHASIVSTLLaLMDGLDNRgQVVVIGATNRPDALDPAL 158
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
381-499 7.56e-09

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 55.49  E-value: 7.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 381 PFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGD-VAPLGSQAVTKIHQIFDWAkKSNKGLLLFIDEADAFLCERNS 459
Cdd:cd19518   33 PPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEiVSGVSGESEEKIRELFDQA-ISNAPCIVFIDEIDAITPKRES 111
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 332661274 460 tymseAQR-----------SALNALLFRTGDQSRdiVLVL-ATNRRGDLDSA 499
Cdd:cd19518  112 -----AQRemerrivsqllTCMDELNNEKTAGGP--VLVIgATNRPDSLDPA 156
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
385-500 1.29e-08

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 54.42  E-value: 1.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 385 MMFYGPPGTGKTMVAREIARKSGLDYAMMTGgdvAPLGSQAVTK----IHQIFDWAKKSNKgLLLFIDEADAfLCERNST 460
Cdd:cd19530   33 VLLYGPPGCGKTLLAKAVANESGANFISVKG---PELLNKYVGEseraVRQVFQRARASAP-CVIFFDEVDA-LVPKRGD 107
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 332661274 461 YMSEAQRSALNALLFRT--GDQSRDIVLVLATNRRGDLDSAV 500
Cdd:cd19530  108 GGSWASERVVNQLLTEMdgLEERSNVFVIAATNRPDIIDPAM 149
ftsH CHL00176
cell division protein; Validated
318-583 4.18e-08

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 56.21  E-value: 4.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 318 ESSMRRFPWTGSVsqFKNrISGAAaasaaEGKKPLDNVIlhtSLKKRIERLARATANtkshqaPFRNMMFYGPPGTGKTM 397
Cdd:CHL00176 169 KARFQMEADTGIT--FRD-IAGIE-----EAKEEFEEVV---SFLKKPERFTAVGAK------IPKGVLLVGPPGTGKTL 231
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 398 VAREIARKSGLDYAMMTGGD-VAPLGSQAVTKIHQIFDWAkKSNKGLLLFIDEADAFLCERNSTYM--SEAQRSALNALL 474
Cdd:CHL00176 232 LAKAIAGEAEVPFFSISGSEfVEMFVGVGAARVRDLFKKA-KENSPCIVFIDEIDAVGRQRGAGIGggNDEREQTLNQLL 310
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 475 -----FRtgdQSRDIVLVLATNRRGDLDSAVT--DRIDEVIEFPLPGEEERFKLLNLYLnkylkmgdNNedtkpkwshlf 547
Cdd:CHL00176 311 temdgFK---GNKGVIVIAATNRVDILDAALLrpGRFDRQITVSLPDREGRLDILKVHA--------RN----------- 368
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 332661274 548 KKLSQKITVEedltdkvisEAAKKTEGFSGREIAKL 583
Cdd:CHL00176 369 KKLSPDVSLE---------LIARRTPGFSGADLANL 395
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
376-454 4.57e-08

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 55.86  E-value: 4.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 376 KSHQAPfrNMMFYGPPGTGKTMVAREIARKSGLDYAMMTggdvAPLGSqaVTKIHQIFDWAKK---SNKGLLLFIDE--- 449
Cdd:PRK13342  32 EAGRLS--SMILWGPPGTGKTTLARIIAGATDAPFEALS----AVTSG--VKDLREVIEEARQrrsAGRRTILFIDEihr 103
                         90
                 ....*....|
gi 332661274 450 -----ADAFL 454
Cdd:PRK13342 104 fnkaqQDALL 113
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
384-454 1.35e-07

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 54.29  E-value: 1.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 384 NMMFYGPPGTGKTMVAREIARKSGLDYAMM---TGGdvaplgsqaVTKIHQIFDWAKK---SNKGLLLFIDE-------- 449
Cdd:COG2256   51 SMILWGPPGTGKTTLARLIANATDAEFVALsavTSG---------VKDIREVIEEARErraYGRRTILFVDEihrfnkaq 121

                 ....*
gi 332661274 450 ADAFL 454
Cdd:COG2256  122 QDALL 126
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
99-255 1.74e-07

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 54.36  E-value: 1.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274   99 RKQEKTRLAELTAETSHY--------------EAIQAHNDIGRQQKLAEDQRNLLQTQAQTKAQNLRYEDELARKRQQTD 164
Cdd:pfam17380 360 RELERIRQEEIAMEISRMrelerlqmerqqknERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRR 439
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  165 HEAQRHHNVELVKMQEASsiRKEKAKIATEEQIQAQHRQTEKERAELERETIRV--KAMAEAEGRAHEAKLTEEQNRRLL 242
Cdd:pfam17380 440 LEEERAREMERVRLEEQE--RQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEqrRKILEKELEERKQAMIEEERKRKL 517
                         170
                  ....*....|...
gi 332661274  243 MERINGEREKWLA 255
Cdd:pfam17380 518 LEKEMEERQKAIY 530
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
99-232 6.14e-07

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 52.18  E-value: 6.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  99 RKQEKTRLAELTAETSHYEAIQAHNDIGRQQKLAEDQRNLLQTQAQTKAQnlrYEDELARKRQQTDHEAQRHHNVELVKM 178
Cdd:COG2268  218 QANREAEEAELEQEREIETARIAEAEAELAKKKAEERREAETARAEAEAA---YEIAEANAEREVQRQLEIAEREREIEL 294
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 332661274 179 QEASSIRKEKAKIATEEQIQAQHRQTEKERAELERETIRVKAMAEAEGRAHEAK 232
Cdd:COG2268  295 QEKEAEREEAELEADVRKPAEAEKQAAEAEAEAEAEAIRAKGLAEAEGKRALAE 348
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
385-500 7.64e-07

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 49.43  E-value: 7.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 385 MMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAPLG-SQAVTKIHQIFDWAKKSnKGLLLFIDEADAFLCER----NS 459
Cdd:cd19527   29 ILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYiGESEANVREVFQKARDA-KPCVIFFDELDSLAPSRgnsgDS 107
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 332661274 460 TYMSEAQRSALNALLFRTGDQSRDIVLVLATNRRGDLDSAV 500
Cdd:cd19527  108 GGVMDRVVSQLLAELDGMSSSGQDVFVIGATNRPDLLDPAL 148
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
73-242 8.57e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 52.25  E-value: 8.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  73 EALERAAKALRDINSSPHSKQVFDLMRKQEKTRLAELTAETShyEAIQAHNDIGRQQKLAEDQRNLLQTQAQTKAQNLRY 152
Cdd:COG1196  285 EAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELA--ELEEELEELEEELEELEEELEEAEEELEEAEAELAE 362
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 153 EDELARKRQQTDHEAQRHHNVELVKMQEASSIRKEKAKIATEEQIQAQHRQTEKERAELERETIRVKAMAEAEGRAHEAK 232
Cdd:COG1196  363 AEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEE 442
                        170
                 ....*....|
gi 332661274 233 LTEEQNRRLL 242
Cdd:COG1196  443 ALEEAAEEEA 452
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
383-500 1.49e-06

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 48.64  E-value: 1.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 383 RNMMFYGPPGTGKTMVAREIARK-SGLDYAMMTGGDV-APLGSQAVTKIHQIF-----DW-AKKSNKGLLLFI-DEADAF 453
Cdd:cd19504   36 KGILLYGPPGTGKTLMARQIGKMlNAREPKIVNGPEIlNKYVGESEANIRKLFadaeeEQrRLGANSGLHIIIfDEIDAI 115
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 332661274 454 LCERNSTYMSEA-QRSALNALLFRTG--DQSRDIVLVLATNRRGDLDSAV 500
Cdd:cd19504  116 CKQRGSMAGSTGvHDTVVNQLLSKIDgvEQLNNILVIGMTNRKDLIDEAL 165
44 PHA02544
clamp loader, small subunit; Provisional
352-518 3.55e-06

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 49.22  E-value: 3.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 352 LDNVILHTSLKKRIERLaratanTKSHQAPfrNMMFYGP-PGTGKTMVAREIARKSGLDYAMMTGGDvaplgsqavTKIH 430
Cdd:PHA02544  20 IDECILPAADKETFKSI------VKKGRIP--NMLLHSPsPGTGKTTVAKALCNEVGAEVLFVNGSD---------CRID 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 431 QIFDWAKK-------SNKGLLLFIDEADaflcernSTYMSEAQ---RSALNALlfrtgdqSRDIVLVLATNRRGDLDSAV 500
Cdd:PHA02544  83 FVRNRLTRfastvslTGGGKVIIIDEFD-------RLGLADAQrhlRSFMEAY-------SKNCSFIITANNKNGIIEPL 148
                        170
                 ....*....|....*...
gi 332661274 501 TDRIDeVIEFPLPGEEER 518
Cdd:PHA02544 149 RSRCR-VIDFGVPTKEEQ 165
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
357-511 1.21e-05

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 48.30  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  357 LHTSLKKRIERLAR--ATANTKSHqapfrnMMFYGPPGTGKTMVAREIARKsgldYAMMTggdvaPLGSQAVTKIHQ--- 431
Cdd:TIGR03922 291 LKSSTAMALARAERglPVAQTSNH------MLFAGPPGTGKTTIARVVAKI----YCGLG-----VLRKPLVREVSRadl 355
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  432 ----IFDWAKKSNK------GLLLFIDEADAFLCERNSTyMSEAQRSALNALLFRTgDQSRDIVLVLATNRRGDLDSAVT 501
Cdd:TIGR03922 356 igqyIGESEAKTNEiidsalGGVLFLDEAYTLVETGYGQ-KDPFGLEAIDTLLARM-ENDRDRLVVIGAGYRKDLDKFLE 433
                         170
                  ....*....|....*.
gi 332661274  502 ------DRIDEVIEFP 511
Cdd:TIGR03922 434 vneglrSRFTRVIEFP 449
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
379-509 2.21e-05

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 45.11  E-value: 2.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 379 QAPFR---NMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAP--LGS--QAVtkiHQIFDWAkKSNKGLLLFIDEAD 451
Cdd:cd19526   21 SSPLRlrsGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNkyIGAseQNV---RDLFSRA-QSAKPCILFFDEFD 96
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 332661274 452 AFLCER--NSTYMSEaqrSALNALLFR-TGDQSRDIVLVLATNRRGDL-DSAV--TDRIDEVIE 509
Cdd:cd19526   97 SIAPKRghDSTGVTD---RVVNQLLTQlDGVEGLDGVYVLAATSRPDLiDPALlrPGRLDKLVY 157
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
96-258 2.37e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 47.62  E-value: 2.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  96 DLMRKQEKTRLAELTAETSHYEAIQAHndigRQQKLAEDQRNLLQTQAQTKAQNLRYEDELARKRQQTDHEAQRHHNVEL 175
Cdd:COG1196  235 RELEAELEELEAELEELEAELEELEAE----LAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER 310
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 176 VKMQEASSIRKEKAKIATEEQIQAQHRQTEKERAELERETIRVKAMAEAEGRAHEAKLTEEQNRRLLMERINGEREKWLA 255
Cdd:COG1196  311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLE 390

                 ...
gi 332661274 256 AIN 258
Cdd:COG1196  391 ALR 393
PTZ00121 PTZ00121
MAEBL; Provisional
79-252 1.13e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.52  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274   79 AKALRDINSSPHSKQVFDLMRKQEKTRLAELTAETSHYEAIQAHNDIGRQ--QKLAEDQRNLLQTQAQTKAQNLRYEDEL 156
Cdd:PTZ00121 1539 AKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKaeEARIEEVMKLYEEEKKMKAEEAKKAEEA 1618
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  157 ARKRQQTDHEAQRHHNVELVKMQEASSIRKEKAKIATEEQIQAQHRQTEKERAELERETIRVKAMAEAEGRAHEAKLTEE 236
Cdd:PTZ00121 1619 KIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEA 1698
                         170
                  ....*....|....*.
gi 332661274  237 QNRRLLMERINGEREK 252
Cdd:PTZ00121 1699 EEAKKAEELKKKEAEE 1714
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
380-503 2.24e-04

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 42.18  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 380 APFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAPLGSQAVTKIHQIFDWAKKSNKGLLLFIDEADAFLCERNS 459
Cdd:cd19523   31 RLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKILQASFLAARCRQPSVLFISDLDALLSSQDD 110
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 332661274 460 TY--MSEAQRSALNALLFRTGDQSRDIVLVLATNRRGDLDSAVTDR 503
Cdd:cd19523  111 EAspVGRLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRY 156
PRK13341 PRK13341
AAA family ATPase;
384-470 3.80e-04

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 43.50  E-value: 3.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 384 NMMFYGPPGTGKTMVAREIARKsgldyammTGGDVAPLGS--QAVTKIHQIFDWAK----KSNKGLLLFIDEADAFlcer 457
Cdd:PRK13341  54 SLILYGPPGVGKTTLARIIANH--------TRAHFSSLNAvlAGVKDLRAEVDRAKerleRHGKRTILFIDEVHRF---- 121
                         90
                 ....*....|...
gi 332661274 458 NStymseAQRSAL 470
Cdd:PRK13341 122 NK-----AQQDAL 129
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
349-418 3.99e-04

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 41.78  E-value: 3.99e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 332661274 349 KKPLDNVilHTSL---KKRI-ERLArATANTKSHQAPFrnMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDV 418
Cdd:cd19500    5 RKVLDAD--HYGLedvKERIlEYLA-VRKLKGSMKGPI--LCLVGPPGVGKTSLGKSIARALGRKFVRISLGGV 73
PTZ00121 PTZ00121
MAEBL; Provisional
57-252 4.06e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 4.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274   57 KSKAEPDEPKGSGFDPEALERAAKAlrDINSSPHSKQVFDLMRKQEKTRLAELTAETSHYEAIQAHNDIGRQQKLAEDQR 136
Cdd:PTZ00121 1321 KKKAEEAKKKADAAKKKAEEAKKAA--EAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKK 1398
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  137 NllQTQAQTKAQNLRYEDELARKRQQTDHEAQRHHNVELVKMQEASSIRKEKAKIATEEQIQAQHrqtEKERAELERETI 216
Cdd:PTZ00121 1399 K--AEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEE---AKKKAEEAKKAD 1473
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 332661274  217 RVKAMAEAEGRAHEAKLTEEQNRRLLMERINGEREK 252
Cdd:PTZ00121 1474 EAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAK 1509
PTZ00121 PTZ00121
MAEBL; Provisional
22-239 8.57e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 8.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274   22 SQNRAYADSSRFRFPFFSSSPSPPPSDSPANQSSSKSKAEPDEPKGSGFDPEALERAaKALRDINSSPHSKQVFDLMRKQ 101
Cdd:PTZ00121 1362 AEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKK-KADEAKKKAEEKKKADEAKKKA 1440
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  102 EKTRLAElTAETSHYEAIQAHNdigrQQKLAEDQRNllQTQAQTKAQNLRYEDELARKRQQTDHEAQRHHNVELVKMQEA 181
Cdd:PTZ00121 1441 EEAKKAD-EAKKKAEEAKKAEE----AKKKAEEAKK--ADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKAD 1513
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 332661274  182 SSIRKEKAKIATEEQIQAQHRQTEKER-AELERETIRVKAmAEAEGRAHEAKLTEEQNR 239
Cdd:PTZ00121 1514 EAKKAEEAKKADEAKKAEEAKKADEAKkAEEKKKADELKK-AEELKKAEEKKKAEEAKK 1571
PTZ00121 PTZ00121
MAEBL; Provisional
51-269 1.12e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274   51 ANQSSSKSKAEPDEPKGSGFDPEALERAakalRDINSSPHSKQVFDLMRKQEKTRLAEltaETSHYEAIQAHNDIGRQQK 130
Cdd:PTZ00121 1060 AEAKAHVGQDEGLKPSYKDFDFDAKEDN----RADEATEEAFGKAEEAKKTETGKAEE---ARKAEEAKKKAEDARKAEE 1132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  131 L--AEDQRNLLQTQAQTKAQNL----RYED----ELARKRQQTDHEAQRHHNVELVKMQE---ASSIRK-EKAKIATEEQ 196
Cdd:PTZ00121 1133 ArkAEDARKAEEARKAEDAKRVeiarKAEDarkaEEARKAEDAKKAEAARKAEEVRKAEElrkAEDARKaEAARKAEEER 1212
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 332661274  197 iqaqhRQTEKERAELEREtirvkamAEAEGRAHEAKLTEEQNRRLLMERINGEREKWLAAINTMFSHIEGGFR 269
Cdd:PTZ00121 1213 -----KAEEARKAEDAKK-------AEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIK 1273
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
118-237 1.17e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 41.72  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 118 AIQAHNDIGRQQKLAEDQRNLLQTQAQTKAQNLRYEDELARKRQQTDhEAQRHHNVELVKMQEassirkEKAKIATEEQI 197
Cdd:PRK09510  60 VVEQYNRQQQQQKSAKRAEEQRKKKEQQQAEELQQKQAAEQERLKQL-EKERLAAQEQKKQAE------EAAKQAALKQK 132
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 332661274 198 QAqhrqteKERAELERETIRVKAMAEAEGRAHEAKLTEEQ 237
Cdd:PRK09510 133 QA------EEAAAKAAAAAKAKAEAEAKRAAAAAKKAAAE 166
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
380-400 1.23e-03

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 40.60  E-value: 1.23e-03
                          10        20
                  ....*....|....*....|.
gi 332661274  380 APFRNMMFYGPPGTGKTMVAR 400
Cdd:pfam01078  20 AGGHNLLMIGPPGSGKTMLAK 40
PTZ00491 PTZ00491
major vault protein; Provisional
101-233 1.50e-03

major vault protein; Provisional


Pssm-ID: 240439 [Multi-domain]  Cd Length: 850  Bit Score: 41.54  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 101 QEKTRLAELTAETshyEAIQ------AHNDIGRQQKLAEDQRNLLQTQAQTKAQNLRYEDELA--RKRQQTDHE-AQRHH 171
Cdd:PTZ00491 696 EQRTKLLELQAES---AAVEssgqsrAEALAEAEARLIEAEAEVEQAELRAKALRIEAEAELEklRKRQELELEyEQAQN 772
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 332661274 172 NVELVKMQEASSIRKEKakiaTEEQIQAqhrqtekeraeLERETIrvKAMAEAeGRAHEAKL 233
Cdd:PTZ00491 773 ELEIAKAKELADIEATK----FERIVEA-----------LGRETL--IAIARA-GPELQAKL 816
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
53-232 1.84e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 40.95  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  53 QSSSKSKAEPDEPKGSGFDPEALERAAKALRDInssphskqvfdlmRKQEKTRLAeltAETSHYEAIQAHNDIGRQQKLA 132
Cdd:PRK09510  71 QKSAKRAEEQRKKKEQQQAEELQQKQAAEQERL-------------KQLEKERLA---AQEQKKQAEEAAKQAALKQKQA 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 133 EDQRNLLQTQAQTKAQNLRYEDELARKrqQTDHEAQRHHNVELVKMQEASSIRK----EKAKIATEEQIQAQHRQTEKER 208
Cdd:PRK09510 135 EEAAAKAAAAAKAKAEAEAKRAAAAAK--KAAAEAKKKAEAEAAKKAAAEAKKKaeaeAAAKAAAEAKKKAEAEAKKKAA 212
                        170       180
                 ....*....|....*....|....
gi 332661274 209 AELERetirvKAMAEAEGRAHEAK 232
Cdd:PRK09510 213 AEAKK-----KAAAEAKAAAAKAA 231
DEXXQc_Helz-like cd18038
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ...
370-398 2.64e-03

DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350796 [Multi-domain]  Cd Length: 229  Bit Score: 39.91  E-value: 2.64e-03
                         10        20
                 ....*....|....*....|....*....
gi 332661274 370 RATANTKSHQAPFrnmMFYGPPGTGKTMV 398
Cdd:cd18038   11 RNIVTGTSRPPPY---IIFGPPGTGKTVT 36
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
362-449 2.76e-03

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 39.02  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  362 KKRIERLARATANTKSHQAPFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTG------GDVAPLgsqaVTKIhqifdw 435
Cdd:pfam05496  13 EKVKENLKIFIEAAKQRGEALDHVLLYGPPGLGKTTLANIIANEMGVNIRITSGpaierpGDLAAI----LTNL------ 82
                          90
                  ....*....|....
gi 332661274  436 akksNKGLLLFIDE 449
Cdd:pfam05496  83 ----EPGDVLFIDE 92
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
363-517 3.40e-03

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 40.31  E-value: 3.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  363 KRIERLARATANTKSHQAPfRNMMFYGPPGTGKTMVAR-------EIARKSGLD--------------YAMM-------- 413
Cdd:TIGR02928  22 EQIEELAKALRPILRGSRP-SNVFIYGKTGTGKTAVTKyvmkeleEAAEDRDVRvvtvyvncqildtlYQVLvelanqlr 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  414 -TGGDVAPLGSQAVTKIHQIFDWAKKSNKGLLLFIDEADAFLCERNSTYMSeaqrsalnalLFRT---GDQSRDIVLVLA 489
Cdd:TIGR02928 101 gSGEEVPTTGLSTSEVFRRLYKELNERGDSLIIVLDEIDYLVGDDDDLLYQ----------LSRArsnGDLDNAKVGVIG 170
                         170       180       190
                  ....*....|....*....|....*....|...
gi 332661274  490 ----TNRRGDLDSAVTDR-IDEVIEFPLPGEEE 517
Cdd:TIGR02928 171 isndLKFRENLDPRVKSSlCEEEIIFPPYDAEE 203
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
361-517 3.97e-03

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 39.57  E-value: 3.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 361 LKKRIERLARATANTKSHQApfrnMMFYGPPGTGKTMVAREIAR---------------KSGLDYAMMTGGDV----APL 421
Cdd:COG0470    1 QEEAWEQLLAAAESGRLPHA----LLLHGPPGIGKTTLALALARdllcenpeggkacgqCHSRLMAAGNHPDLlelnPEE 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 422 GSQAVTK--IHQIFDWAKKS---NKGLLLFIDEADAflcernstyMSEAqrsALNALLfRT-GDQSRDIVLVLATNRRGD 495
Cdd:COG0470   77 KSDQIGIdqIRELGEFLSLTpleGGRKVVIIDEADA---------MNEA---AANALL-KTlEEPPKNTPFILIANDPSR 143
                        170       180
                 ....*....|....*....|..
gi 332661274 496 LDSAVTDRIdEVIEFPLPGEEE 517
Cdd:COG0470  144 LLPTIRSRC-QVIRFRPPSEEE 164
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
384-400 4.23e-03

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 40.02  E-value: 4.23e-03
                         10
                 ....*....|....*..
gi 332661274 384 NMMFYGPPGTGKTMVAR 400
Cdd:COG0606  213 NLLMIGPPGSGKTMLAR 229
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
127-234 6.10e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 39.72  E-value: 6.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  127 RQQKLAEDQRNLLQTQAQTKAQNLRYEDELARKRQQTDHEAQRHHNVELVKMQEASSIRKEKAKIATEEQIQAQHRQTEK 206
Cdd:pfam17380 484 RDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKATE 563
                          90       100       110
                  ....*....|....*....|....*....|.
gi 332661274  207 ERAEL---ERETIRVKAMAEAEGRAHEAKLT 234
Cdd:pfam17380 564 ERSRLeamEREREMMRQIVESEKARAEYEAT 594
PRK12704 PRK12704
phosphodiesterase; Provisional
128-249 6.72e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 39.38  E-value: 6.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274 128 QQKLAEDQRNLLQTQAQTKAQNLRYE------DELARKRQQTDHEAQRHHNvELVKMQ------------EASSIRKEKA 189
Cdd:PRK12704  32 KIKEAEEEAKRILEEAKKEAEAIKKEalleakEEIHKLRNEFEKELRERRN-ELQKLEkrllqkeenldrKLELLEKREE 110
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 332661274 190 KI-ATEEQIQAQHRQTEKERAELERetIRVKAMAEAEgraHEAKLTEEQNRRLLMERINGE 249
Cdd:PRK12704 111 ELeKKEKELEQKQQELEKKEEELEE--LIEEQLQELE---RISGLTAEEAKEILLEKVEEE 166
PTZ00121 PTZ00121
MAEBL; Provisional
76-252 7.80e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 7.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274   76 ERAAKALRDINSSPHSKQVFDLMRKQEKTRLAELTAETSHYEAIQAHNDIGRQQKLAEDQRNLLQTQAQTKAQNLRYEDE 155
Cdd:PTZ00121 1240 EEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADE 1319
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  156 LARKRQQTDHEAQR-HHNVELVKMQEASSIRKEKAKIATEEQIQAQHRQTEKERAELERETIRVKAMAEAEGRAHEAKLT 234
Cdd:PTZ00121 1320 AKKKAEEAKKKADAaKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKK 1399
                         170
                  ....*....|....*...
gi 332661274  235 EEQNRRLLMERINGEREK 252
Cdd:PTZ00121 1400 AEEDKKKADELKKAAAAK 1417
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
99-252 7.93e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 39.16  E-value: 7.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274   99 RKQEKTRLAELTAEtshyEAIQAHNDIGRQQKLAEDQRNLLQTQaQTKAQNLRYEDELARKR---------QQTDHEAQR 169
Cdd:pfam15709 328 REQEKASRDRLRAE----RAEMRRLEVERKRREQEEQRRLQQEQ-LERAEKMREELELEQQRrfeeirlrkQRLEEERQR 402
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  170 HHNVElVKMQEASSIRKEKAKIATEE------QIQAQHRQTEKERAELERETIRVKAMAEAEGRAHEAKLTEEQnrRLLM 243
Cdd:pfam15709 403 QEEEE-RKQRLQLQAAQERARQQQEEfrrklqELQRKKQQEEAERAEAEKQRQKELEMQLAEEQKRLMEMAEEE--RLEY 479

                  ....*....
gi 332661274  244 ERINGEREK 252
Cdd:pfam15709 480 QRQKQEAEE 488
PTZ00121 PTZ00121
MAEBL; Provisional
53-252 8.79e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.35  E-value: 8.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274   53 QSSSKSKAEpdEPKGSGFDPEALERAAKALRDINSSpHSKQVFDLMRKQEKTRLAEL-TAETSHYEAIQAHNDigRQQKL 131
Cdd:PTZ00121 1559 KAEEKKKAE--EAKKAEEDKNMALRKAEEAKKAEEA-RIEEVMKLYEEEKKMKAEEAkKAEEAKIKAEELKKA--EEEKK 1633
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661274  132 AEDQRNLLQTQAQTKAQNLRYEDELA--RKRQQTDHEAQRHHNVELVKMQEASSIRKEKAKIATEEQIQAQHRQTEKERA 209
Cdd:PTZ00121 1634 KVEQLKKKEAEEKKKAEELKKAEEENkiKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAE 1713
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 332661274  210 ELERETIRVKAMAEAEGRAHEAKLTEEQNRRLLMERINGEREK 252
Cdd:PTZ00121 1714 EKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEK 1756
PRK04182 PRK04182
cytidylate kinase; Provisional
389-410 9.81e-03

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 37.48  E-value: 9.81e-03
                         10        20
                 ....*....|....*....|..
gi 332661274 389 GPPGTGKTMVAREIARKSGLDY 410
Cdd:PRK04182   7 GPPGSGKTTVARLLAEKLGLKH 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH