BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661416  54 GADVLIHTDDNGLIYAHSNVIGMASDVIRGMMKQHKRKSHRKSISILGVPHHALRVFIRFLYSSCYEKQDMEDFAIHLLV 133
Cdd:cd18313    1 GADVEIETDNNSHIPAHSNVLASASPVIAGMLKQPRRKSSKKVIKILGVPCDAVRVFIRFLYSSCYEEEEMEKFGIHLLV 80

                         90       100
                 ....*....|....*....|..
gi 332661416 134 LSHVYVVPHLKRVCESEFESSL 155
Cdd:cd18313   81 LSHVYVVPQLKRVCEKGLEQGL 102

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 332661416 157 NKENVIDVFQLALLCDAPRLGLLCHRMILNNFEEVSTSEGWQAMKEShprLQKELLRS 214
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVE---LLLELLSS 55

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661416  54 GADVLIHTDDNGLIYAHSNVIGMASDVIRGMMKQHKRKSHRKSISILGVPHHALRVFIRFLYSSCYEKQDMEDFAIHLLV 133
Cdd:cd18313    1 GADVEIETDNNSHIPAHSNVLASASPVIAGMLKQPRRKSSKKVIKILGVPCDAVRVFIRFLYSSCYEEEEMEKFGIHLLV 80

                         90       100
                 ....*....|....*....|..
gi 332661416 134 LSHVYVVPHLKRVCESEFESSL 155
Cdd:cd18313   81 LSHVYVVPQLKRVCEKGLEQGL 102

TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1. The zinc coordinating motif that is necessary for binding to target DNA sequences consists of HCCC.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661416  238 LYEAMEAFVHICRdgCREIGPTKtetphmsCGFQACNGLEQLLKHLAGCKLRsipGGCS--RCKRMWQLLElHSRICVDs 315
Cdd:pfam02135   1 LQRWLLLLLHASK--CSAPGPGP-------CSLPNCRKMKRLLRHMATCKRG---GGCPypHCKRSRQLLR-HAKNCKD- 66

                  ....*
gi 332661416  316 EQCKV 320
Cdd:pfam02135  67 EDCPV 71

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661416    56 DVLIHTDDnGLIYAHSNVIGMASDVIRGMMKQHKRKSHRKSISILGVPHHALRVFIRFLYSscYEKQDMEDFAIHLLVLS 135
Cdd:smart00225   1 DVTLVVGG-KKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYT--GKLDLPEENVEELLELA 77

                           90       100
                   ....*....|....*....|
gi 332661416   136 HVYVVPHLKRVCESEFESSL 155
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKLL 97

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 332661416   161 VIDVFQLALLCDAPRLGLLCHRMILNNFEEVSTSEGWQAMkeSHPRLQkELLRS 214
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLEL--PLEQLL-ELLSS 51

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661416  54 GADVLIHTDDNGLIYAHSNVIGMASDVIRGMMKQHKRKSHRKSISILGVPHHALRVFIRFLYSSCYEKQDMEDFAIHLLV 133
Cdd:cd18313    1 GADVEIETDNNSHIPAHSNVLASASPVIAGMLKQPRRKSSKKVIKILGVPCDAVRVFIRFLYSSCYEEEEMEKFGIHLLV 80

                         90       100
                 ....*....|....*....|..
gi 332661416 134 LSHVYVVPHLKRVCESEFESSL 155
Cdd:cd18313   81 LSHVYVVPQLKRVCEKGLEQGL 102

TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1. The zinc coordinating motif that is necessary for binding to target DNA sequences consists of HCCC.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661416  238 LYEAMEAFVHICRdgCREIGPTKtetphmsCGFQACNGLEQLLKHLAGCKLRsipGGCS--RCKRMWQLLElHSRICVDs 315
Cdd:pfam02135   1 LQRWLLLLLHASK--CSAPGPGP-------CSLPNCRKMKRLLRHMATCKRG---GGCPypHCKRSRQLLR-HAKNCKD- 66

                  ....*
gi 332661416  316 EQCKV 320
Cdd:pfam02135  67 EDCPV 71

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661416   46 DRMFDEAHGADVLIHTDDnGLIYAHSNVIGMASDVIRGMMKQHKRKSHRKSISILGVPHHALRVFIRFLYSSCYEKQDMe 125
Cdd:pfam00651   2 NELREQGELCDVTLVVGD-KEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLISEEN- 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 332661416  126 dfAIHLLVLSHVYVVPHLKRVCESEFESSL 155
Cdd:pfam00651  80 --VDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661416  67 IYAHSNVIGMASDVIRGMMKQHKRKSHRKSISILGVPHHALRVFIRFLYSSCYEKQDMEDFAIH-LLVLSHVYVVPHLKR 145
Cdd:cd18297   24 FYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVESLDVAQDDALeLLRAASFFQLDGLKR 103

                         90
                 ....*....|
gi 332661416 146 VCESEFESSL 155
Cdd:cd18297  104 HCEILLSQQI 113

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661416  55 ADVLIHTDDnGLIYAHSNVIGMASDVIRGMMKQHKRKSHRKSISILGVPHHALRVFIRFLYS-SCYEKQDMEdfAIHLLV 133
Cdd:cd18300   10 SDVTFIVED-GTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTdQAPILEDGD--CVGLIV 86

                         90
                 ....*....|....*
gi 332661416 134 LSHVYVVPHLKRVCE 148
Cdd:cd18300   87 LANRLCLPRLVALCE 101

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 332661416 157 NKENVIDVFQLALLCDAPRLGLLCHRMILNNFEEVSTSEGWQAMKEShprLQKELLRS 214
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVE---LLLELLSS 55

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661416  68 YAHSNVIGMASDVIRGMMKQHKRKSHRKSISILGVPHHALRVFIRFLYSSCYEKQdmEDFAIHLLVLSHVYVVPHLKRVC 147
Cdd:cd18352   26 YAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDIT--NDIAKDLLRAADQYLLEGLKRLC 103

                 .
gi 332661416 148 E 148
Cdd:cd18352  104 E 104

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 332661416   161 VIDVFQLALLCDAPRLGLLCHRMILNNFEEVSTSEGWQAMkeSHPRLQkELLRS 214
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLEL--PLEQLL-ELLSS 51

BACK (BTB and C-terminal Kelch) domain found in TD and POZ domain-containing proteins, Tdpoz1-4; TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", and are not inlcuded in this subfamily.

                         10        20
                 ....*....|....*....|....*..
gi 332661416 190 EVSTSEGWQAMKESHPRLQKELLRSVA 216
Cdd:cd18521   35 EVSETSEWKSMVESHPHLVAEAFHSLA 61

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332661416  43 DSWDRMFDEAHGADVLIHTDDNgLIYAHSNVIGMASDVIRGMMKQHKRKSHRKSISILGVPHHALRVFIRFLYSSCYEkQ 122
Cdd:cd18298    1 DSLRKAFNDPRTSDLKFRVDGK-YIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVD-L 78

                         90       100
                 ....*....|....*....|....*.
gi 332661416 123 DMEDfAIHLLVLSHVYVVPHLKRVCE 148
Cdd:cd18298   79 PPED-AIGLLDLANSYCEERLKKLCE 103