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Conserved domains on  [gi|347990749|gb|AEP40515|]
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chimeric cellulase FnCel5A-TfCBM2a [synthetic construct]

Protein Classification

CBD_II domain-containing protein; CBD_II domain-containing protein; CBD_II domain-containing protein; cellulose-binding domain-containing protein( domain architecture ID 11457718)

CBD_II domain-containing protein; CBD_II domain-containing protein; CBD_II domain-containing protein; cellulose-binding domain-containing protein similar to Mycobacterium tuberculosis protein Rv1987, a functional beta-glucan-targeting protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
BglC COG2730
Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism];
20-309 3.60e-87

Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism];


:

Pssm-ID: 442036 [Multi-domain]  Cd Length: 295  Bit Score: 267.68  E-value: 3.60e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749  20 IGHGINMGNALEAPVEGSWGvYIEDEYFKIIKERGFDSVRIPIRWSAHISEKYPYEIDKFFLDRVKHVVDVALKNDLVVI 99
Cdd:COG2730    6 RLRGVNLGNWLELWFETLWG-NITEEDIDAIADWGFNTVRLPVSWERLQDPDNPYTLDEAYLERVDEVVDWAKARGLYVI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749 100 INCHHFEELY-QAPDKYGPVLVEIWKQVAQAFKDYPDKLFFEIFNEPAQNlTPTKWNELYPKVLGEIRKTNPSRIVIIDV 178
Cdd:COG2730   85 LDLHHAPGYQgWYDAATQERFIAFWRQLAERYKDYPNVLGFELLNEPHGA-TWADWNALAQRAIDAIRATNPDRLIIVEG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749 179 PNWSNYSYVRELKLVDDKNIIVSFHYYEPFNFTHQGAEWVSPTLPigvkwegkdwevEQIRNHFKYVSEWAKKNNVPIFL 258
Cdd:COG2730  164 NNWGGAHNLRALDPLDDDNLVYSVHFYGPFVFTHQGAWFAGPTYP------------ANLEARLDNWGDWAADNGVPVFV 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 347990749 259 GEFGAYSKADMESRVKWTKTVRRIAEEFGFSLAYWEFCAG---FGLYDRWTKTW 309
Cdd:COG2730  232 GEFGAYNDDPDASRLAWLRDLLDYLEENGIGWTYWSFNPSgdtGGLLDRGTGDW 285
CBM_2 pfam00553
Cellulose binding domain; Two tryptophan residues are involved in cellulose binding. Cellulose ...
 342-440 3.00e-46

Cellulose binding domain; Two tryptophan residues are involved in cellulose binding. Cellulose binding domain found in bacteria.


:

Pssm-ID: 425748 [Multi-domain]  Cd Length: 101  Bit Score: 154.91  E-value: 3.00e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749  342 CSVDYTV-NSWGTGFTANVTITNLGSA-INGWTLEWDFPGNQQVTNLWNGTYTQSGQHVSVSNAPYNASIPANGTVEFGF 419
Cdd:pfam00553   1 CTATYAVtNQWGTGFTANVTITNTGSSpINGWTVSWTYPAGQRVTQSWNATVSQSGNPVTATNVSWNGTIAPGGSASFGF 80

                          90       100
                  ....*....|....*....|.
gi 347990749  420 NGSYSGSNDIPSSFKLNGVTC 440
Cdd:pfam00553  81 QGSGTGSNSAPTSFTVNGAAC 101
 
Name Accession Description Interval E-value
BglC COG2730
Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism];
20-309 3.60e-87

Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism];


Pssm-ID: 442036 [Multi-domain]  Cd Length: 295  Bit Score: 267.68  E-value: 3.60e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749  20 IGHGINMGNALEAPVEGSWGvYIEDEYFKIIKERGFDSVRIPIRWSAHISEKYPYEIDKFFLDRVKHVVDVALKNDLVVI 99
Cdd:COG2730    6 RLRGVNLGNWLELWFETLWG-NITEEDIDAIADWGFNTVRLPVSWERLQDPDNPYTLDEAYLERVDEVVDWAKARGLYVI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749 100 INCHHFEELY-QAPDKYGPVLVEIWKQVAQAFKDYPDKLFFEIFNEPAQNlTPTKWNELYPKVLGEIRKTNPSRIVIIDV 178
Cdd:COG2730   85 LDLHHAPGYQgWYDAATQERFIAFWRQLAERYKDYPNVLGFELLNEPHGA-TWADWNALAQRAIDAIRATNPDRLIIVEG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749 179 PNWSNYSYVRELKLVDDKNIIVSFHYYEPFNFTHQGAEWVSPTLPigvkwegkdwevEQIRNHFKYVSEWAKKNNVPIFL 258
Cdd:COG2730  164 NNWGGAHNLRALDPLDDDNLVYSVHFYGPFVFTHQGAWFAGPTYP------------ANLEARLDNWGDWAADNGVPVFV 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 347990749 259 GEFGAYSKADMESRVKWTKTVRRIAEEFGFSLAYWEFCAG---FGLYDRWTKTW 309
Cdd:COG2730  232 GEFGAYNDDPDASRLAWLRDLLDYLEENGIGWTYWSFNPSgdtGGLLDRGTGDW 285
Cellulase pfam00150
Cellulase (glycosyl hydrolase family 5);
35-293 2.97e-47

Cellulase (glycosyl hydrolase family 5);


Pssm-ID: 395098 [Multi-domain]  Cd Length: 272  Bit Score: 163.70  E-value: 2.97e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749   35 EGSWG--VYIEDEYFKIIKERGFDSVRIPIRWSAHISEKYPYEIDKFFLDRVKHVVDVALKNDLVVIINCHH-------- 104
Cdd:pfam00150  16 GGQWGnpYVTTKAMIDLVKDWGFNVVRLPVSWGGYVPNNPDYLIDENWLNRVDEVVDYAIDNGMYVIIDWHHdggwpgdp 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749  105 FEELYQAPDKYgpvlVEIWKQVAQAFkDYPDKLFFEIFNEP---AQNLTPTKWNELYPKVLGEIRKTNPSRIVIIDVPNW 181
Cdd:pfam00150  96 NGNIDTAKAFF----KKIWTQIATRY-GNNPNVIFELMNEPhgnDQATWADDVKDYAQEAIDAIRAAGPNNLIIVGGNSW 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749  182 SNYSYVRELKL-VDDKNIIVSFHYYEPFNFTHQGAEWVSPTlpigvkwegkdWEVEQIRNHFKyvseWAKKNNVPIFLGE 260
Cdd:pfam00150 171 SQNPDGAALNDpNDDDNLIYSVHFYAPSDFSGTWFDCEDPT-----------NLAQRLRAAAN----WALDNGIPVFIGE 235

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 347990749  261 FGA--YSKADMESRVKWtktvRRIAEEFGFSLAYW 293
Cdd:pfam00150 236 FGGgnADGPCRDEAEKW----LDYLKENGISWTGW 266
CBM_2 pfam00553
Cellulose binding domain; Two tryptophan residues are involved in cellulose binding. Cellulose ...
 342-440 3.00e-46

Cellulose binding domain; Two tryptophan residues are involved in cellulose binding. Cellulose binding domain found in bacteria.


Pssm-ID: 425748 [Multi-domain]  Cd Length: 101  Bit Score: 154.91  E-value: 3.00e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749  342 CSVDYTV-NSWGTGFTANVTITNLGSA-INGWTLEWDFPGNQQVTNLWNGTYTQSGQHVSVSNAPYNASIPANGTVEFGF 419
Cdd:pfam00553   1 CTATYAVtNQWGTGFTANVTITNTGSSpINGWTVSWTYPAGQRVTQSWNATVSQSGNPVTATNVSWNGTIAPGGSASFGF 80

                          90       100
                  ....*....|....*....|.
gi 347990749  420 NGSYSGSNDIPSSFKLNGVTC 440
Cdd:pfam00553  81 QGSGTGSNSAPTSFTVNGAAC 101
CelA1 COG5297
Cellulase/cellobiase CelA1 [Carbohydrate transport and metabolism];
297-440 9.28e-43

Cellulase/cellobiase CelA1 [Carbohydrate transport and metabolism];


Pssm-ID: 444099 [Multi-domain]  Cd Length: 301  Bit Score: 152.67  E-value: 9.28e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749 297 AGFGLYDRWTKTWIEPLTTSAlgpgTYPSYSPKPSPRPTkpPVASCSVDYTV-NSWGTGFTANVTITNLGS-AINGWTLE 374
Cdd:COG5297  162 TGGGIANQPTAVWDRIAAITA----TVRAHLDAALAAPL--PGRDCGVTYSVySDWGSGYTAAVTVTNPGSlPLNGWTLA 235

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 347990749 375 WDFPGNQQVTNLWNGTYTQSGQHVSVSNAPYNASIPANGTVEFGFNGSYSGSNdiPSSFKLNGvTC 440
Cdd:COG5297  236 WDLPGGAGVTNAWGFTLNQSGYTVTATNVSWNGTLAPGGSVSFGFDTSRNGWN--PSGRGLDG-AC 298
CBD_II smart00637
CBD_II domain;
348-439 2.25e-37

CBD_II domain;


Pssm-ID: 214754 [Multi-domain]  Cd Length: 92  Bit Score: 131.38  E-value: 2.25e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749   348 VNSWGTGFTANVTITNLGS-AINGWTLEWDFPGNQQVTNLWNGTYTQSGQHVSVSNAPYNASIPANGTVEFGFNGsYSGS 426
Cdd:smart00637   1 TSDWGSGFTANVTVTNTGSsAINGWTLTFDLPGGQTVTNSWNATVSQSGGHVTATNASWNGTIAPGGSVSFGFQG-KTGS 79

                           90
                   ....*....|...
gi 347990749   427 NDIPSSFKLNGVT 439
Cdd:smart00637  80 SAAPTGFTLNGAA 92
 
Name Accession Description Interval E-value
BglC COG2730
Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism];
20-309 3.60e-87

Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism];


Pssm-ID: 442036 [Multi-domain]  Cd Length: 295  Bit Score: 267.68  E-value: 3.60e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749  20 IGHGINMGNALEAPVEGSWGvYIEDEYFKIIKERGFDSVRIPIRWSAHISEKYPYEIDKFFLDRVKHVVDVALKNDLVVI 99
Cdd:COG2730    6 RLRGVNLGNWLELWFETLWG-NITEEDIDAIADWGFNTVRLPVSWERLQDPDNPYTLDEAYLERVDEVVDWAKARGLYVI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749 100 INCHHFEELY-QAPDKYGPVLVEIWKQVAQAFKDYPDKLFFEIFNEPAQNlTPTKWNELYPKVLGEIRKTNPSRIVIIDV 178
Cdd:COG2730   85 LDLHHAPGYQgWYDAATQERFIAFWRQLAERYKDYPNVLGFELLNEPHGA-TWADWNALAQRAIDAIRATNPDRLIIVEG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749 179 PNWSNYSYVRELKLVDDKNIIVSFHYYEPFNFTHQGAEWVSPTLPigvkwegkdwevEQIRNHFKYVSEWAKKNNVPIFL 258
Cdd:COG2730  164 NNWGGAHNLRALDPLDDDNLVYSVHFYGPFVFTHQGAWFAGPTYP------------ANLEARLDNWGDWAADNGVPVFV 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 347990749 259 GEFGAYSKADMESRVKWTKTVRRIAEEFGFSLAYWEFCAG---FGLYDRWTKTW 309
Cdd:COG2730  232 GEFGAYNDDPDASRLAWLRDLLDYLEENGIGWTYWSFNPSgdtGGLLDRGTGDW 285
Cellulase pfam00150
Cellulase (glycosyl hydrolase family 5);
35-293 2.97e-47

Cellulase (glycosyl hydrolase family 5);


Pssm-ID: 395098 [Multi-domain]  Cd Length: 272  Bit Score: 163.70  E-value: 2.97e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749   35 EGSWG--VYIEDEYFKIIKERGFDSVRIPIRWSAHISEKYPYEIDKFFLDRVKHVVDVALKNDLVVIINCHH-------- 104
Cdd:pfam00150  16 GGQWGnpYVTTKAMIDLVKDWGFNVVRLPVSWGGYVPNNPDYLIDENWLNRVDEVVDYAIDNGMYVIIDWHHdggwpgdp 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749  105 FEELYQAPDKYgpvlVEIWKQVAQAFkDYPDKLFFEIFNEP---AQNLTPTKWNELYPKVLGEIRKTNPSRIVIIDVPNW 181
Cdd:pfam00150  96 NGNIDTAKAFF----KKIWTQIATRY-GNNPNVIFELMNEPhgnDQATWADDVKDYAQEAIDAIRAAGPNNLIIVGGNSW 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749  182 SNYSYVRELKL-VDDKNIIVSFHYYEPFNFTHQGAEWVSPTlpigvkwegkdWEVEQIRNHFKyvseWAKKNNVPIFLGE 260
Cdd:pfam00150 171 SQNPDGAALNDpNDDDNLIYSVHFYAPSDFSGTWFDCEDPT-----------NLAQRLRAAAN----WALDNGIPVFIGE 235

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 347990749  261 FGA--YSKADMESRVKWtktvRRIAEEFGFSLAYW 293
Cdd:pfam00150 236 FGGgnADGPCRDEAEKW----LDYLKENGISWTGW 266
CBM_2 pfam00553
Cellulose binding domain; Two tryptophan residues are involved in cellulose binding. Cellulose ...
 342-440 3.00e-46

Cellulose binding domain; Two tryptophan residues are involved in cellulose binding. Cellulose binding domain found in bacteria.


Pssm-ID: 425748 [Multi-domain]  Cd Length: 101  Bit Score: 154.91  E-value: 3.00e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749  342 CSVDYTV-NSWGTGFTANVTITNLGSA-INGWTLEWDFPGNQQVTNLWNGTYTQSGQHVSVSNAPYNASIPANGTVEFGF 419
Cdd:pfam00553   1 CTATYAVtNQWGTGFTANVTITNTGSSpINGWTVSWTYPAGQRVTQSWNATVSQSGNPVTATNVSWNGTIAPGGSASFGF 80

                          90       100
                  ....*....|....*....|.
gi 347990749  420 NGSYSGSNDIPSSFKLNGVTC 440
Cdd:pfam00553  81 QGSGTGSNSAPTSFTVNGAAC 101
CelA1 COG5297
Cellulase/cellobiase CelA1 [Carbohydrate transport and metabolism];
297-440 9.28e-43

Cellulase/cellobiase CelA1 [Carbohydrate transport and metabolism];


Pssm-ID: 444099 [Multi-domain]  Cd Length: 301  Bit Score: 152.67  E-value: 9.28e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749 297 AGFGLYDRWTKTWIEPLTTSAlgpgTYPSYSPKPSPRPTkpPVASCSVDYTV-NSWGTGFTANVTITNLGS-AINGWTLE 374
Cdd:COG5297  162 TGGGIANQPTAVWDRIAAITA----TVRAHLDAALAAPL--PGRDCGVTYSVySDWGSGYTAAVTVTNPGSlPLNGWTLA 235

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 347990749 375 WDFPGNQQVTNLWNGTYTQSGQHVSVSNAPYNASIPANGTVEFGFNGSYSGSNdiPSSFKLNGvTC 440
Cdd:COG5297  236 WDLPGGAGVTNAWGFTLNQSGYTVTATNVSWNGTLAPGGSVSFGFDTSRNGWN--PSGRGLDG-AC 298
CBD_II smart00637
CBD_II domain;
348-439 2.25e-37

CBD_II domain;


Pssm-ID: 214754 [Multi-domain]  Cd Length: 92  Bit Score: 131.38  E-value: 2.25e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347990749   348 VNSWGTGFTANVTITNLGS-AINGWTLEWDFPGNQQVTNLWNGTYTQSGQHVSVSNAPYNASIPANGTVEFGFNGsYSGS 426
Cdd:smart00637   1 TSDWGSGFTANVTVTNTGSsAINGWTLTFDLPGGQTVTNSWNATVSQSGGHVTATNASWNGTIAPGGSVSFGFQG-KTGS 79

                           90
                   ....*....|...
gi 347990749   427 NDIPSSFKLNGVT 439
Cdd:smart00637  80 SAAPTGFTLNGAA 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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