|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
19-390 |
7.98e-113 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 334.54 E-value: 7.98e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 19 LYMVFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGL 98
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 99 CALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSMFGWRYPFLLPFA 178
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 179 AIPVALWITLRLKQNRTATNHKAGNPFKEMLKAFSNPLAILLFSTSTVTFIILYGAFLTFLPFHLNTSFQATALQIGLIS 258
Cdd:cd17474 161 LIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 259 AFMSFTSAVVAFNMKGIS-KALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEE 337
Cdd:cd17474 241 AGWSVLLALGSLFVGRLLkKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 355396663 338 NRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYF 390
Cdd:cd17474 321 ERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
24-392 |
1.62e-60 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 200.11 E-value: 1.62e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 24 AVTLLSVLGVASVTPAFPQIAE-FFGISPAKTGLVVssfTIPGLVA---TPLLGLLADRYGRKKVLVPCLLLFGVSGGLC 99
Cdd:cd17473 6 LASTLTVMAGAAIAPALPAIAQhFVPNSELLVPLLL---TLPALFIalfAPLAGWLADRFGRKRLLIAGLLLYGIGGVAG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 100 ALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSMFGWRYPFLLPFAA 179
Cdd:cd17473 83 LFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 180 IPVAL--WITLRlkqNRTATNHKAGNPFKEMLKAFSNPLAILLFSTSTVTFIILYgAFLTFLPFHLNTSFQATALQIGLI 257
Cdd:cd17473 163 LPVLIlvLLFLP---EPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFY-VIPIQLPFLLQERGGGSAALIGLA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 258 SAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEE 337
Cdd:cd17473 239 LAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPE 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 355396663 338 NRAAFISLNSMSLRLGQTLGPFLMGGIYSL-FGIRSVFSSGAILAAVMASVLYFAL 392
Cdd:cd17473 319 LRGRAMGIVTSAFFLGQFLSPLVLGPLVNLtGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
22-390 |
7.28e-51 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 174.69 E-value: 7.28e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 22 VFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCAL 101
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 102 SRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLL-SMFGWRYPFLLPFAAI 180
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLaDALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 181 PVALWITLRLKQ---NRTATNHKAGNPFKEMLKAFSNPLAILLFSTSTVTFIILYGAFLTFLPFHLNTSFQATALQIGLI 257
Cdd:cd17325 161 LLALVLALLLLPeprPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 258 SAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEE 337
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 355396663 338 NRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYF 390
Cdd:cd17325 321 GRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
19-356 |
2.29e-46 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 162.45 E-value: 2.29e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 19 LYMVFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGL 98
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 99 CALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLL-SMFGWRYPFLLpf 177
Cdd:COG2814 92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLaDLFGWRWVFLV-- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 178 AAIPVALWITLRLKQNRTATNHKAGNPFKEMLKAFSNPLAILLFSTSTVTFIILYgAFLTFLPFHLNTSFQATALQIGLI 257
Cdd:COG2814 170 NAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFF-ALFTYLPLYLQEVLGLSASAAGLL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 258 SAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEE 337
Cdd:COG2814 249 LALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPE 328
|
330
....*....|....*....
gi 355396663 338 NRAAFISLNSMSLRLGQTL 356
Cdd:COG2814 329 ARGRASGLYNSAFFLGGPL 347
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
22-392 |
4.07e-36 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 135.41 E-value: 4.07e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 22 VFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCAL 101
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 102 SRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSMFGWRYPFLLPFAAIP 181
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 182 VALWITLRLKQNRTATNHKAGNPFKEMLKAFSNPlAILLFSTSTVTFIILYGAFLTFLPFHLNTSFQAtalQIGLISAFM 261
Cdd:cd17489 161 LLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEK-KVLPPALILFLASIAYGAISTFLPLYAAERGIS---NAGLFFTVY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 262 SFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEENRAA 341
Cdd:cd17489 237 AIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 355396663 342 FISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYFAL 392
Cdd:cd17489 317 ANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
26-389 |
4.56e-36 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 135.38 E-value: 4.56e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 26 TLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSF 105
Cdd:cd17321 5 VFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 106 NELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGG-LLSMFGWRYPFLLPFAAIPVAL 184
Cdd:cd17321 85 AFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGlLLELFGWRWIFLINVPIGLVAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 185 WITlrlkqnrtatnhkagnpfkemlKAFSNPLAILLFSTSTvtfiilYGAFLTFLPFHLNTSFQATALQIGLISAFMSFT 264
Cdd:cd17321 165 LLA----------------------RTFSGAVLAAFLLGAA------LGGLLFLLPLYLQGVLGYSPLQAGLALLPLALA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 265 SAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPN---CLSALIPAGLIGAAQGLNMPTLMTMITNIAPEENRAA 341
Cdd:cd17321 217 MLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGAdssVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGA 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 355396663 342 FISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLY 389
Cdd:cd17321 297 ASGILNTARQLGGALGVALLGALLTAGLSANLGDSGVAALLSAAAAAF 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-397 |
9.10e-36 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 134.23 E-value: 9.10e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 19 LYMVFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGL 98
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 99 CALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTA-TYPAIGGLLSMFGWRYPFLLPf 177
Cdd:COG2271 92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGAlAPPLLGWLLAAFGWRAAFLIL- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 178 aAIPVALWItlrlkqnrtatnhkagnpfkemlkafsnPLAILLFSTSTVTFIILYGAFLTFLPFHLNTSFQATALQIGLI 257
Cdd:COG2271 171 -GLPGLLLA----------------------------LLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 258 SAFMSFTSAVVAFNMKGISKALSERYR--LFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAP 335
Cdd:COG2271 222 LSLPFLAGIVGSLLGGWLSDRLGRRRKlvLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFP 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 355396663 336 EENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYFALKPTQR 397
Cdd:COG2271 302 KKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
19-387 |
1.74e-33 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 128.44 E-value: 1.74e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 19 LYMVFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGL 98
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 99 CALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLS-MFGWRYPFLLPF 177
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGqLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 178 AAIPVALWITLRLKQNRTATNHKAGNPFKEMLKAFSNPLAILLFSTSTVTFIILYGAFlTFLPFHLNTSFQATALQIGLI 257
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALY-TYLAPFLTDVPGFSSSAIIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 258 SAFMSFTSAVVAFnmkgISKALSERY---RLFLAFILYCLALI-IALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNI 333
Cdd:cd17324 240 LLLFGVAGVVGSP----LAGRLADRGgrrALLIALLLLAAALLlLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 355396663 334 APeENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASV 387
Cdd:cd17324 316 AP-EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLL 368
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
19-390 |
3.97e-32 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 124.23 E-value: 3.97e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 19 LYMVFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGL 98
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 99 CALSRSFNELLMMRVLQGIGASALnSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSMFgwrYPFLLPFA 178
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP---YGYALPFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 179 AIPVAlwitlrlkqnrtatnhkagnpfkemlkAFSNPLAILLFSTSTVTFIILY-------GAFLTFLPFHLNTSFQATA 251
Cdd:cd17330 157 VAAAL---------------------------ALLNLVLVLFFLPPLRRLLLVYflialafAGLESVFSLFLKDRFGFSP 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 252 LQIGLISAFMSFTSAVVAFNMKGIS-KALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMI 330
Cdd:cd17330 210 SQIGLLLALVGIAGILAQLLLIPRLaKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALL 289
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 331 TNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYF 390
Cdd:cd17330 290 SKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
22-358 |
1.23e-31 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 122.91 E-value: 1.23e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 22 VFAVTLLSVLGVASVTPAFPQ-IAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCA 100
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 101 LSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLL-SMFGWRYPFLLP--- 176
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLaSLFGWRAAFLILail 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 177 --FAAIPVALWITLRLKQNRTATNHKAGNPFKEMLKAFSNPLAILLFstSTVTFIILYGAFLTFLPFHLNTsFQATALQI 254
Cdd:pfam07690 161 slLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLL--ALLLFGFAFFGLLTYLPLYQEV-LGLSALLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 255 GLISAFMSFTSAVVAFNMKGISKALSERYRLFLA---FILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMIT 331
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAlllLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVS 317
|
330 340
....*....|....*....|....*..
gi 355396663 332 NIAPEENRAAFISLNSMSLRLGQTLGP 358
Cdd:pfam07690 318 DLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-397 |
1.61e-30 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 120.76 E-value: 1.61e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 18 NLYMVFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGG 97
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 98 LCALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTA-TYPAIGGLLSMFGWRYPFLLP 176
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAvAAFLAPLLIAAFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 177 FAAIPVALWITLRLKQNRTATNHKAGN-PFKEMLKAFSNPLAILLFSTSTVTFIILYGaFLTFLPFHLNTSFQATALQIG 255
Cdd:COG2223 166 GILLLVVAVLAWLFLRDPPAGAAAAAKaSLRDQLEALRDPRFWLLSLLYFGTFGSFIG-FSSWLPPYLVDQFGLSAATAG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 256 LISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPA-GLIGAAQGLNMPTLMTMITNIA 334
Cdd:COG2223 245 LLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLfLLLGLALGGGNGAVFALVPDIF 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 355396663 335 PEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFG-IRSVFSSGAILAAVMASVLYFALKPTQR 397
Cdd:COG2223 325 PTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
21-329 |
7.36e-29 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 115.75 E-value: 7.36e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 21 MVFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCA 100
Cdd:cd17320 3 LLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 101 LSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSM-FGWRYPFLLPFA- 178
Cdd:cd17320 83 LASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLfFGWRAIFVFLALl 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 179 AIPVALWITLRLKQnrTATNHKAGNPFKEMLKAFSNPLAILLFSTSTVTFIILYGAFLTFL---PFHLNTSFQATALQIG 255
Cdd:cd17320 163 GLLLLLLVLLFLPE--TLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLaaaPFIYIEQLGLSPAQFG 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 355396663 256 LISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALI-----IALNLPNCLSALIPAGLIGAAQGLNMPTLMTM 329
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALvlllaALLGGLSLWPLVAPLFLIFFGFGLIFPNATSL 319
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
26-369 |
7.98e-28 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 113.05 E-value: 7.98e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 26 TLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSF 105
Cdd:cd17503 5 AFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 106 NELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLS-MFGWRYPFL--LPFAAIPV 182
Cdd:cd17503 85 ASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTdNLSWRWIFYinLPIGILAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 183 ALWITLRlkqnrtatnhkagnpfkemLKAFSNPLAILLFSTSTVTFIILYGAFLTfLPFHLNTSFQATALQIGLISAFMS 262
Cdd:cd17503 165 LLAPLLD-------------------LRLFKDRNFTLGLLLSFLLGLGLFGAMFL-LPLYLQNVLGYSAFESGLVLAPGG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 263 FTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALI---PAGLIGAAQGLNMPTLMTMITNIAPEENR 339
Cdd:cd17503 225 LASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLiilPLFIRGLGMGLVFMPLNTLALNSLPPEQI 304
|
330 340 350
....*....|....*....|....*....|
gi 355396663 340 AAFISLNSMSLRLGQTLGPFLMGGIYSLFG 369
Cdd:cd17503 305 GDATALFNTIRQLGGSIGTALLATLLTNRT 334
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
23-391 |
3.31e-27 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 111.17 E-value: 3.31e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 23 FAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALS 102
Cdd:cd06173 5 WLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 103 RSFNE-----LLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLL-SMFGWRYPFLLP 176
Cdd:cd06173 85 ALLGSlslwlLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLvALLGPGGAFAIN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 177 FAAIPVALWITLRLKQNRTATNHKAGNP----FKEMLKAFSNPLAILLFSTSTVTFIILYGAFLTFLPFHLNTSFQATAL 252
Cdd:cd06173 165 ALSFLLSALLLLFIRRPPPAAPGESSSLllrdLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 253 QIGLISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITN 332
Cdd:cd06173 245 GYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQL 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 355396663 333 IAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYFA 391
Cdd:cd06173 325 RVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
22-386 |
4.01e-27 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 109.96 E-value: 4.01e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 22 VFAVTLLSVLGVASVTPAFPQIAEFFGiSPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCAL 101
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 102 SRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLS-MFGWRYPFL--LPFA 178
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTdHLSWRWCFYinLPIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 179 AIPVALwitLRlkqnrtatnhkagnpfkemlkafsnplAILLFSTSTVTFIILYGAFLTFLPFHLNTSFQATALQIGLIS 258
Cdd:cd17502 160 GLALAL---LR---------------------------TILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 259 AFMSFTSAVVAFNM-KGISKALSERYRLFLAFIL--YCLALIIALNLPNCLSALIPAGLI-GAAQGLNMPTLMTMITNIA 334
Cdd:cd17502 210 LPLIIGLVIGSIISgALISKTGRYKPLIVIGTILmsVGAGLLTTLTLDTSKWLLIGYLILlGLGLGIGFQQPLVAVQNAV 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 355396663 335 PEENRAAFISLNSMSLRLGQTLGpflmGGIYSLFGIRSVFSSGAILAAVMAS 386
Cdd:cd17502 290 PPADVGVATATNTFFRSLGGTLG----VAITDVFLVALALAALAFLLSLFLP 337
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
22-390 |
1.10e-25 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 106.74 E-value: 1.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 22 VFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCAL 101
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 102 SRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSM---FGWRYPFLLP-- 176
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslgFGWRAVFLIAaa 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 177 ---FAAIPVALWI-TLRLKQNRTATNHKAGNPFKEMLKAFSNPlAILLFSTSTVTFIILYGAFLTFLPFHLNTSFQATAL 252
Cdd:cd06174 161 lalLAAILLLLVVpDPPESARAKNEEASSKSVLKLLKRVLKNP-GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 253 QIGLISAFMSFTSAVVAFNMKGIS-KALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMIT 331
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSdRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 355396663 332 NIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYF 390
Cdd:cd06174 320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
19-297 |
1.64e-25 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 104.89 E-value: 1.64e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 19 LYMVFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGL 98
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 99 CALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLL-SMFGWRYPFLLPF 177
Cdd:COG0477 96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLvAALGWRWIFLINA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 178 AAIPVALWITLRLKQNRTATNHKAGNPFKEMLKAFSNPLAILLFSTSTVTFIILYGAFLTFLPFHLNTSFQATALQIGLI 257
Cdd:COG0477 176 PLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLA 255
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 355396663 258 SAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALI 297
Cdd:COG0477 256 LLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
24-391 |
3.51e-25 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 105.35 E-value: 3.51e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 24 AVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSR 103
Cdd:cd17504 3 LAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 104 SFNELLMMRVLQGIGaSALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLS-MFGWRYPFLLPFAAIPV 182
Cdd:cd17504 83 NLPVLIAGRALQGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVqHLGWRWIFWTAAPVAVL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 183 ALWITLRLKqnrtatnhkagnpfkemLKAFSNPLAILLFSTSTVTFIILYGAFLTfLPFHLNTSFQATALQIGLISAFMS 262
Cdd:cd17504 162 LAALVPLID-----------------LRLLRRRNVLLANITALLAGFGMFMVFQL-LPQLLQLPTPTGFGLGITEAGLLL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 263 FTSAVVAFNMKGISKALSERYR----LFLAFILYCLALIIALNLPNCLSALIPAGLI-GAAQGLNMPTLMTMITNIAPEE 337
Cdd:cd17504 224 LPGALVMLIAGPLAGRLIARVGprrvLLIGLVISAVGLLLLALLHSSLWALVVALLLiGIGLGLAFASLPNIVVESVPPD 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 355396663 338 NRAAFISLNSMSLRLGQTLGPFLMGGI---YSLFGIRSVFSSGA--ILAAVMASVLYFA 391
Cdd:cd17504 304 RTGIATGMNTVLRTIGSAIGPAIAGAIlttYTVSITSGGVPTEGayVLAFLIGAALALA 362
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
38-393 |
3.84e-25 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 105.38 E-value: 3.84e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 38 PAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLF-GVSGGLCALSRSFNELLMMRVLQG 116
Cdd:cd17490 17 PFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFtVLASLIMILFPSPWGLLIARFLSG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 117 IGASALNSLNITIIGdLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLS-MFGWRYPFLLPFAAIPVALWITLRLKQNRt 195
Cdd:cd17490 97 IAAATWVSFTVLYAS-YFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAeHFGMRAPFLLAALAGVLGFILSLFIKEER- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 196 ATNHKAGNPFKEMLKAFSNPLAILLFSTSTVTFIILYGAFLTFLPFHLNtSFQATALQIGLISAFMSFTSAVVA-FNMKG 274
Cdd:cd17490 175 REKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAK-QLGASSFQLGLLSIIYLLPNALASlLSGTL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 275 ISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEENRAAFISLNSMSLRLGQ 354
Cdd:cd17490 254 FYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGM 333
|
330 340 350
....*....|....*....|....*....|....*....
gi 355396663 355 TLGPFLMGGIYSLFGIRSVFSSGAILAAVmASVLYFALK 393
Cdd:cd17490 334 FLGPVLVGIISEAFGLQTGFFVIGVIALL-AAILSLAYY 371
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
19-397 |
8.47e-25 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 104.55 E-value: 8.47e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 19 LYMVFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGL 98
Cdd:COG0738 10 LIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 99 CALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTeAMGYNSSVLGIGTATYPAIGGLLSMFG----WRYPFL 174
Cdd:COG0738 90 FALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAS-RLNLLHAFFSLGALLGPLLGGLLILLGlslsWHLPYL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 175 LpFAAIPVALWITLRLKQ--NRTATNHKAGNPFKEMLKAFSNPlAILLFSTSTVTFIILYGAFLTFLPFHLNTSFQATAL 252
Cdd:COG0738 169 I-LAVLLLLLALLFLRSKlpEIEEEEEEAAGSAASLKSLLKNP-RLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 253 QIGLISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITN 332
Cdd:COG0738 247 TAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALD 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 355396663 333 IAPeENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYFALKPTQR 397
Cdd:COG0738 327 GLG-KRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
43-389 |
1.19e-24 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 103.85 E-value: 1.19e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 43 IAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGASAL 122
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 123 NSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSMFGWRYPFLLPFAA-IPVALWITLRLKQNRTATNHKA 201
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLfLLAALVLLFLLPETRPKRRAAE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 202 GNPFKEMLKAFSNPLAILLFSTSTVTFIILYGAFLTFLPFHLNTSFQATALQIGLISAFMSFTSAVVAFNMKGISKALSE 281
Cdd:cd17329 186 KTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 282 RYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLM 361
Cdd:cd17329 266 RKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVG 345
|
330 340
....*....|....*....|....*...
gi 355396663 362 GGIYSLFGIRSVFSSGAILAAVMASVLY 389
Cdd:cd17329 346 GLLLDLLGPGLPWLILAALGLIAAALLL 373
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
55-392 |
8.51e-23 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 98.88 E-value: 8.51e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 55 GLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIgASALNSLNITIIGDLY 134
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGV-FSGYVPNATALIASQT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 135 KEKYRTEAMGYNSSVLGIGTATYPAIGGLLS-MFGWRYPFLLPFAAIPVALWITLRL-KQNRTATNHKAGNPFKEMLKAF 212
Cdd:cd17391 118 PKEKSGWALGTLSTGVVAGTLIGPLLGGFLAdLFGIRNVFFITGGLLFLAFLLTLFFvKEDFKPVEKKKMVSTKEVWNSV 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 213 SNPLaiLLFSTSTVTFIILYGAF-----LTFLPFHLNTSFQATALQIGLISAFMSFTSAVVAFNMKGISKALSERYRLFL 287
Cdd:cd17391 198 PNPS--LLISLFVTTFIIQLANQsiepiLTLYIRQLMGDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLG 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 288 AFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSL 367
Cdd:cd17391 276 ALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAH 355
|
330 340
....*....|....*....|....*
gi 355396663 368 FGIRSVFSSGAILAAVMASVLYFAL 392
Cdd:cd17391 356 FGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
22-395 |
2.42e-22 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 97.64 E-value: 2.42e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 22 VFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCAL 101
Cdd:COG2807 23 IVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 102 SRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKyRTEAMGYNSSVLGIGTATYPAIGG-LLSMFGWRYPFLL--PFA 178
Cdd:COG2807 103 APSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVpLAAALGWRGALAVwaLLA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 179 AIPVALWITLRLKQNRTATNHKAGNPFKEMLKafsNPLAILLfstsTVTFII---LYGAFLTFLPFHLnTSFQATALQIG 255
Cdd:COG2807 182 LLALLLWLPLLRRRPAAAAAAPAAASLRSLWR---SPLAWLL----TLFFGLqslLYYAVVAWLPPIL-RDAGLSAATAG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 256 LISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAP 335
Cdd:COG2807 254 LLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRAR 333
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 355396663 336 EENRAAfiSLNSMSL---RLGQTLGPFLMGGIYSLFG-IRSVFSSGAILAAVMASVLYFALKPT 395
Cdd:COG2807 334 TPAEAA--ALSGMAQsvgYLLAALGPLLVGALHDATGsWTAALLLLAALAVLMLVAGLLAGRPY 395
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
21-392 |
1.49e-20 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 91.86 E-value: 1.49e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 21 MVFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCA 100
Cdd:cd17319 7 LLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 101 LSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTA-TYPAIGGLLSMFGWRYPFLLPFAA 179
Cdd:cd17319 87 FATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAiGPPLSGWLLLLFGWRWAFIIEGLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 180 IPVALWITLRLkqnrtatnhkagnpFKEMLKafsnpLAILLFSTSTVTFiilygAFLTFLPFHLNTSFQATALQIGLISA 259
Cdd:cd17319 167 GLLLAVLWWFY--------------LRQVWG-----LALGYFGINYALY-----GLLTWLPTYLKQARGFSLKQVGLLAA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 260 FMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNM---PTLMTMITNIAPE 336
Cdd:cd17319 223 IPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGaasPVFWSLPADLLPG 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 355396663 337 ENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYFAL 392
Cdd:cd17319 303 EAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
19-392 |
4.09e-20 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 91.16 E-value: 4.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 19 LYMVFAVTLLSVLGVASVTPAFPQIAEFFGIS----PAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGV 94
Cdd:cd17388 1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGDsadaATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 95 SGGLCALSRSFNELLMMRVLQGI-GASalNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSMFGWRYPF 173
Cdd:cd17388 81 DYLLMAFAPTLWWLYLGRIIAGItGAT--GAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 174 LlpFAAIPVAL-----WITLR---LKQNRTATNHKAGNPFKEMLKAFSNPLAILLFSTSTVTFIILYGAFLTFlPFHLNT 245
Cdd:cd17388 159 L--VAAGLNGLnfllgLFVLPeslPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTW-VLFTED 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 246 SFQATALQIGLISAFMSFTSAVV-AFNMKGISKALSERYRLFLAFILYCLALIIaLNLPNCLSALIPAGLIGAAQGLNMP 324
Cdd:cd17388 236 RFDWSPTMVGLSLAVFGLLHALFqAFVTGPIAKRLGEKRAILLGLAADALGFLL-LAFATQGWMVFPILILLALGGIAGP 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 355396663 325 TLMTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIR---SVFSSGAILAAVMASVLYFAL 392
Cdd:cd17388 315 ALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATwpgLAWIIGAALYLICLVLAYRFF 385
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
22-390 |
1.22e-18 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 86.13 E-value: 1.22e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 22 VFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCAL 101
Cdd:cd17390 1 LYLVGFLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 102 SRSFNELLMMRVLQGIGASALnSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSMF--GWRYPFLLPFA- 178
Cdd:cd17390 81 STSLALLFLSRIPLGIFKHTQ-SLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETdgGFYYVALLCSAi 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 179 ---------AIPVALWITLRLKqnrtatnhkagnpfkemlkafsnplaiLLFSTStvtFIILYGAFLTFlpfhLNTSFQA 249
Cdd:cd17390 160 filnaglvwFLLSKLWDLLLVR---------------------------FLMGFS---VLLFRSNFSLY----LEERFDL 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 250 TALQIGLISAFMSFTSAVVAFNMKGISKAL--SERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLM 327
Cdd:cd17390 206 SPKTIGYLISYSGVLGALSGFLVGRILKLYknNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCST 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 355396663 328 TMITNIAPEENRAAFISLNSMSLRLGQTLGPFLmGGIYSLFGIRSVFSSGAILAAVMASVLYF 390
Cdd:cd17390 286 SLLLSRGKSKERGTLLGVGQSVTSLARILAPLL-SGLLQEFSVSGPGLLGAVLALAAILLMLA 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
2-191 |
6.85e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 84.16 E-value: 6.85e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 2 TSGIDNARKRTVLKDENLYMVFAVTLLSVLGVASVTPAFP-QIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYG 80
Cdd:cd17325 184 SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 81 RKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAI 160
Cdd:cd17325 264 RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343
|
170 180 190
....*....|....*....|....*....|..
gi 355396663 161 GGLLS-MFGWRYPFLLPFAAIPVALWITLRLK 191
Cdd:cd17325 344 GGFLYdAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
34-385 |
7.70e-18 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 84.14 E-value: 7.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 34 ASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRV 113
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 114 LQGIGASALNSLNITIIGDLYKEKyRTEAMGYNSSVLGIGTATYPAIGGLLSMFgWRYPFLLPFAAIP----VALWITLR 189
Cdd:cd17478 93 LAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVAL-FGGLGLLILLIIPglavALLLLRLR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 190 LKQNRTATNHKAGNPFKEMLKAFSNPLAILLFSTSTVTFIILygAFLTFLPFHLNTSFQATALQIGLISAFMsFTSAVVA 269
Cdd:cd17478 171 PLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLS--SLTTFLPFYLVQRGYSLVFAGLLLSLFL-FAGAIGT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 270 FNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIpAGLIGAAQGLNMPTLMTMITNIAPEenRAAFISlnSMS 349
Cdd:cd17478 248 LIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYIL-LVLAGFLLFASFPVTVVLAQELLPG--NVGLAS--GLM 322
|
330 340 350
....*....|....*....|....*....|....*....
gi 355396663 350 LRLGQTLG---PFLMGGIYSLFGIRSVFSSGAILAAVMA 385
Cdd:cd17478 323 MGLSFGLGgigAPVLGALADAFGLESVLLILALLPLLGA 361
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
44-393 |
9.87e-18 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 84.57 E-value: 9.87e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 44 AEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYG-----RKKVLVPCLLLFGVSGGLCALSRSFNE------LLMMR 112
Cdd:COG2211 38 TDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDLSPtgkliyALVTY 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 113 VLQGIGASALNSLNITIIGDLYKE-KYRTEAMGYNSSVLGIGTATYPAIGGLL-------SMFGWRYPFLLPFAAIPVAL 184
Cdd:COG2211 118 LLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLvaafggdAALGYRLTALIFAVLGLLAF 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 185 WITLRLKQNRTATNHKAGnPFKEMLKAFSNPLAILLFSTSTVTFIILYGAFLTFLPFHLNTSFQATALQIGLISAFMSFT 264
Cdd:COG2211 198 LLTFFGTKERPVPEEEKV-SLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLA 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 265 SAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLP--NCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEE----- 337
Cdd:COG2211 277 ALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktg 356
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 355396663 338 --NRAAFISLNSMSLRLGQTLGPFLMGGIYSLFG--------------IRSVFSSGAILAAVMASVLYFALK 393
Cdd:COG2211 357 rrREGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspsaltgIRLLFFLLPAVLLLLAALLLLFYP 428
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
22-391 |
2.18e-17 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 82.65 E-value: 2.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 22 VFAVTLLSVLGVASVTPAF-PQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCA 100
Cdd:cd17472 1 LSLIFSLRMLGMFLVLPVLsVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 101 LSRSFNELLMMRVLQGIGasALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLS-MFGWRYPFLL-PFA 178
Cdd:cd17472 81 YATSIYGLILGRALQGSG--AISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAaHLGVSGLFLItAIL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 179 AIPVALWITLRLKQNRTATNHKAgnPFKEMLKAFSNPLAILLFSTSTVTFIILYGAFLTFLPFHLNTSFQATALQI---- 254
Cdd:cd17472 159 SLVSLLILLFFVPDPPKIVQISE--KEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWkvyl 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 255 -GLISAFMSFTSAVVAFNMKGISKALseryrLFLAFILYCLALIIALNLPNCLSALIpAGLIGAAQGLNM--PTLMTMIT 331
Cdd:cd17472 237 pAILIGFILMVPFVIYAEKKGKMKQV-----FVSSILLIAVGFLLLLFAATSLWLLI-IGLIIFFIGFNLleALLPSLVS 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 332 NIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYFA 391
Cdd:cd17472 311 KIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSFLL 370
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
36-369 |
2.23e-17 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 83.05 E-value: 2.23e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 36 VTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQ 115
Cdd:cd17328 18 IAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 116 GIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLL--SMFGWRYPFL---LPFAAIPVALWITL-- 188
Cdd:cd17328 98 GIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaqATGGWRWAFRvtgVLGVLLAILLLLFVre 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 189 --RLKQNRTATNHKAGNPFKEMLKA-FSNPLAILL-FSTSTVTFIIlyGAFLTFLPFHLNTSFQATALQIGLISAFMSFT 264
Cdd:cd17328 178 ppRGAAEGGVMAKSTATSFLADLKAlAKNPSFILStLGFTAVSFVT--GALAFWAPTFFLRAFGVGDLSSADVGLIFGAI 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 265 SAVVAFNMKGISKALSERYR--------LFLAFILYCLALIIALNLPNCLSALIPA----GLIGAAQGLNMPTLMTMITN 332
Cdd:cd17328 256 TCIAGVLGVLLGGILADRLRrktpradpLVCAVGLLAAAPFLFLALVLALSNLLLAwvllFLGEFLLSLNWAPVFAILLY 335
|
330 340 350
....*....|....*....|....*....|....*...
gi 355396663 333 IAPEENRA-AFISLNSMSLRLGQTLGPFLMGGIYSLFG 369
Cdd:cd17328 336 VVIPTRRStASAIQILLSHLLGDAGSPYLIGLISDLLR 373
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
41-395 |
1.24e-16 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 80.81 E-value: 1.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 41 PQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGAS 120
Cdd:cd17371 23 PALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 121 ALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIG-----TATYPAIGGLLSMFGWRYPFLlpFAAIPVALWITLRLK---- 191
Cdd:cd17371 103 GEWAAGAALMAEYVPARHRGKALGYVQSGWAVGwllatLLAALLFPLLPPEIAWRVLFL--LGALPALLVLFIRRFvkep 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 192 ----QNRTATNHKAGNPFKEMLKAFSNPLAILLFSTSTVTFIILYGAFLTFLPFHLNTSFQATALQIGLISAFMSFTSAV 267
Cdd:cd17371 181 pqwqAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 268 VAFNMKGISKALSERYRLFLAFILYCLALIIALNLP----NCLSALIPAGLIGAAQGLNMPTLMtmiTNIAPEENRAAFI 343
Cdd:cd17371 261 GYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPlsptLILILGFPLGFFASGPFSGMGAYL---TELFPTAVRATAQ 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 355396663 344 SLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYFALKPT 395
Cdd:cd17371 338 GFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPET 389
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
27-330 |
2.54e-16 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 79.74 E-value: 2.54e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 27 LLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFN 106
Cdd:TIGR00710 15 ILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIE 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 107 ELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSMF-GWRYPFLLPF-----AAI 180
Cdd:TIGR00710 95 TLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWlSWHAIFAFLSlagilLSA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 181 PVALWITLRLKQNRTATNHKAGNPFKEMLKAFSNPLAILLFSTSTVTFIilygAFLTFLPFHLNTSFQATALQIGLISAF 260
Cdd:TIGR00710 175 LIFFILPETLPYEARIQISTYFETFLLLLKSKMFWGYALIYGASFGGFF----AFFSGAPFVYIDIMGVSPSVFGLLFAL 250
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 355396663 261 MSFTSAVVAFNMKGISKALSERYRLFLAFILYC-----LALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMI 330
Cdd:TIGR00710 251 NIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAvsavlLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAYA 325
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
26-173 |
2.04e-15 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 76.85 E-value: 2.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 26 TLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSF 105
Cdd:cd17323 8 TFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNI 87
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 355396663 106 NELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSMF-GWRYPF 173
Cdd:cd17323 88 AMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSlGWRWIF 156
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
55-175 |
2.37e-15 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 72.30 E-value: 2.37e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 55 GLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGASALNSLNITIIGDLY 134
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 355396663 135 KEKYRTEAMGYNSSVLGIGTATYPAIGGLLSMF-GWRYPFLL 175
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFlGWRAPFLF 122
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
39-189 |
2.29e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 73.93 E-value: 2.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 39 AFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIG 118
Cdd:TIGR00895 39 AAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLG 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 355396663 119 ASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGG-LLSMFGWRYPFLLPFAAIPVALWITLR 189
Cdd:TIGR00895 119 LGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGwLIPVFGWRSLFYVGGIAPLLLLLLLMR 190
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
22-388 |
3.21e-14 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 73.36 E-value: 3.21e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 22 VFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCAL 101
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 102 SRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSMFGWRyPFLLPFAAIP 181
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL-PFLIAAVLLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 182 VALWITLRLKQNRTATNHKAGNPFKEMLKAfsNPLAILlfstSTVTFIILYGAFLTFLPFHLnTSFQATALQIGLISAFM 261
Cdd:cd17477 160 LALVPLLLTRRAAPEIEEAESISLRRLLRI--APLALL----GAFVAGFLEGAFYSLLPLYG-LRLGLSVAQAALLLAAF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 262 SFTSAVVAFNMKGISKALSERY-RLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEENRA 340
Cdd:cd17477 233 VLGGLLLQWPLGWLADRFDRRRvLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELV 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 355396663 341 AFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVL 388
Cdd:cd17477 313 AANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
47-390 |
3.88e-14 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 73.02 E-value: 3.88e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 47 FGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGASALNSLN 126
Cdd:cd17316 31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 127 ITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSM-----FGWRYPFLLPFAAIPVALWITLRLkqnrtatnhka 201
Cdd:cd17316 111 STYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsgdWGWRILFLIGALPALLALLLRRRT----------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 202 gnpfkemlkafsnplaILLFSTSTVTFIILYGaFLTFLPFHLNTSFQATALQIGLISAFMSFTSAVVAFNMKGISKALSE 281
Cdd:cd17316 180 ----------------LLLILLWFFISFGYYG-LTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 282 RYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMP--TLMTMITNIAPEENRAAFISLNSMSLRLGQTLGPF 359
Cdd:cd17316 243 KKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVwgALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPP 322
|
330 340 350
....*....|....*....|....*....|.
gi 355396663 360 LMGGIYSLFGIRSVFSSGAILAAVMASVLYF 390
Cdd:cd17316 323 LIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
26-366 |
9.14e-13 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 69.33 E-value: 9.14e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 26 TLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSF 105
Cdd:TIGR00711 11 TFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 106 NELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLS-MFGWRYPFLL---PFAAIP 181
Cdd:TIGR00711 91 ELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIeNYHWRWIFLInvpIGIIVV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 182 VALWITLR-----LKQN--------------------RTATNHKAGNPFKEMLKAFSNPLAILLF--------------- 221
Cdd:TIGR00711 171 VVAFFILPrdkpaASENfdflgllllsvglgsllyglSEGPERGWFDSNEILILSITGLVAIIAFvvweltddnplvdlr 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 222 -----------STSTVTFIILYGAFLtFLPFHLNTSFQATALQIGLISAfmsfTSAVVAFNMKGISKAL----SERYRLF 286
Cdd:TIGR00711 251 lfkyrnftigcVYMSLLGLGLYGSFY-LLPLYLQQVLGYTALQAGLHIL----PVGLAPMLSSPIAGRMgdkiDPRKLVT 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 287 LAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIA----PEENRAAFISLNSMSLRLGQTLGPFLMG 362
Cdd:TIGR00711 326 IGLILYAVGFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIAlsglPPHKIARGSSLSNFTRQLGGSIGTALIT 405
|
....
gi 355396663 363 GIYS 366
Cdd:TIGR00711 406 TILT 409
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
31-384 |
1.17e-12 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 68.76 E-value: 1.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 31 LGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCAL--SRSFNEL 108
Cdd:cd17335 11 AALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFfvAQIFWLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 109 LMMRVLQGIGASALNSL----NITIIGDlYKEKYRTEAMgYNSSVLGIGTatyPAIGGLLSMFGWRYPFLLPFAAIPVAL 184
Cdd:cd17335 91 LLLVILGAFFSAPVVPLvdsiTLQYLGE-ERERYGKQRL-WGSIGFGIAA---LLVGILIDRSSTYKNYTIAFYVFAVLM 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 185 WITL--RLKQNRTATNHKAGNPFKEMLKAFSNPlAILLFSTSTVTFIILYGAFLTFLPFHLNtSFQATALQIGLISAFMS 262
Cdd:cd17335 166 LLALllALKFPFRPKHPEPNENTGGLLALLRNP-RVLAFLLVAFLMGFGHGLIYSFLFWHLQ-DLGGSKTLIGLLWTVGV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 263 FTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEENRAAF 342
Cdd:cd17335 244 VSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATA 323
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 355396663 343 ISL-NSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVM 384
Cdd:cd17335 324 QGLlQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAG 366
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
38-390 |
1.23e-12 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 68.78 E-value: 1.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 38 PAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRV---- 113
Cdd:cd17331 21 PVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLpsvf 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 114 LQGIGASAlnslniTIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLS-MFGWRYPFL----LPFAAIpVALWITL 188
Cdd:cd17331 101 MHAMQAAQ------MVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTkKFGEQAAALvaavGSLLSI-VLVILLI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 189 RLKQNRTATNHKAGNP-------FKEMLKAFSNPLAILLFSTSTVTFIILyGAFLTFLPFHLNTSFQATALQIGLISAFM 261
Cdd:cd17331 174 PSNTKSKREKEAKESAsppsvfnLKEILRLLRLPGVAFLLLVKLLSGLPI-GMFQSMFSLVAMDFFGLTPEENGYLMSYA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 262 SFTSAVV-AFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEENRA 340
Cdd:cd17331 253 GVLGMVVqGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTG 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 355396663 341 AFISLNsMSLR-LGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYF 390
Cdd:cd17331 333 TALGLS-HALFsLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
221-397 |
1.24e-12 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 68.21 E-value: 1.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 221 FSTSTVTFIILYGAFLTFLPFHLNTSFQATALQIGLISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIAL 300
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 301 NLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAIL 380
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170
....*....|....*..
gi 355396663 381 AAVMASVLYFALKPTQR 397
Cdd:pfam07690 161 SLLAAVLLLLPRPPPES 177
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
19-190 |
3.25e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 67.23 E-value: 3.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 19 LYMVFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGL 98
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 99 CALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTatypAIGGLLSM-----FGWRYPF 173
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGA----ALGGFLAAalipaFGWRSVF 156
|
170 180
....*....|....*....|
gi 355396663 174 LL---PFAAIPVALWITLRL 190
Cdd:cd17365 157 LLggvPPLILLPLLRGTLLL 176
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
216-397 |
5.77e-12 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 66.54 E-value: 5.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 216 LAILLFSTSTVTFIILYGAFLTFLPFhLNTSFQATALQIGLISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLA 295
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 296 LIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFS 375
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170 180
....*....|....*....|..
gi 355396663 376 SGAILAAVMASVLYFALKPTQR 397
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRP 190
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
38-192 |
9.81e-12 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 65.71 E-value: 9.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 38 PAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGI 117
Cdd:PRK11102 12 PALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 355396663 118 GASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGG-LLSMFGWRYPF-LLPFAAIPVALWITLRLKQ 192
Cdd:PRK11102 92 AAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGwLLVWFSWHAIFwVLALAAILAAALVFFFIPE 168
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
23-185 |
1.58e-11 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 65.37 E-value: 1.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 23 FAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALS 102
Cdd:PRK11551 21 FLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 103 RSFNELLMMRVLQGIG-ASALNSLnITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSM-FGWRYPF----LLP 176
Cdd:PRK11551 101 WDFPSLLVARLLTGVGlGGALPNL-IALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGdAAWRHIFyvggVGP 179
|
....*....
gi 355396663 177 FAAIPVALW 185
Cdd:PRK11551 180 LLLVPLLMR 188
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
221-395 |
1.65e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 65.29 E-value: 1.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 221 FSTSTVTFIILYGAFLTFLPFHLnTSFQATALQIGLISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIAL 300
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYA-ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 301 NLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAIL 380
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170
....*....|....*
gi 355396663 381 AAVMASVLYFALKPT 395
Cdd:cd17325 160 ALLALVLALLLLPEP 174
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
25-388 |
1.93e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 64.87 E-value: 1.93e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 25 VTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVpcllLFGVSGGLC----- 99
Cdd:cd17370 7 VSLFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLV----ILGYGLSALakpll 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 100 ALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIG-GLLSMFGWRYPFLLPFA 178
Cdd:cd17370 83 ALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAaLLLYLLGGNYRTIFLLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 179 AIP--VALWITLRLKQNRTATNHKAGNPFKEMLKAFSNPLAILLFStstVTFIILYGAFLTFLPFHLNTSFQATALQIGL 256
Cdd:cd17370 163 AIPalLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLA---VALFALGNFSFAFLILRAQELGLSAALIPLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 257 ISAFMsFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPE 336
Cdd:cd17370 240 YALFN-LVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPA 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 355396663 337 ENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVL 388
Cdd:cd17370 319 ELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
22-392 |
2.34e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 64.60 E-value: 2.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 22 VFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCAL 101
Cdd:cd17355 8 TFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 102 SRSFNEL-LMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATY-PAIGGLLSMFGWR-----YPFL 174
Cdd:cd17355 88 ATSLWQLyLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFlPLGAALIEAFGWRtallvLALL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 175 LPFAAIPVALWITLRL--KQNRTATNHKAGNPFKEMLKAFSNPLAILLFSTSTVTFIILYGAFLTFLPF--HLNTSFQAT 250
Cdd:cd17355 168 ALLVLVPVLLLLRRRPadLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYlaDRGISPAAA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 251 ALQIGLISAFMSFTSAVVAFnmkgISKALSERYRLFLAFILYCLALIIALNLPN-CLSALIPAGLIGAAQGLNMPTLMTM 329
Cdd:cd17355 248 AVALALIGLFNIVGRLLSGW----LGDRYSPRRLLAASYALRALGLALLLLLPFpPLALLLFAALFGLGWGATVPLTAAL 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 355396663 330 ITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYFAL 392
Cdd:cd17355 324 AARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
36-195 |
5.13e-11 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 63.98 E-value: 5.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 36 VTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQ 115
Cdd:PRK10504 29 VNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQ 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 116 GIGASALNSLN-ITIIGDLYKEKYRTeAMGYNSSVLGIGTATYPAIGGLLSMFG-WRYPFLLPFAAIPVALWITLRLKQN 193
Cdd:PRK10504 109 GVGGAMMVPVGrLTVMKIVPREQYMA-AMTFVTLPGQVGPLLGPALGGLLVEYAsWHWIFLINIPVGIIGAIATLMLMPN 187
|
..
gi 355396663 194 RT 195
Cdd:PRK10504 188 YT 189
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
31-385 |
9.82e-11 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 62.72 E-value: 9.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 31 LGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLM 110
Cdd:cd17333 10 LTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 111 MRVLQGIGASALNSLNITIIGDLYKEKyRTEAMGYNSSVLGIGTATYPAIGGLL--SMFGWRYPFLLPFA-AIPVALWIT 187
Cdd:cd17333 90 LMFLAGLGAGILDTGANTFVGALFEES-SATRLNVLHGFFGLGALIGPLIATSLltSELSWSWAYLIIGLiYLLLAILIL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 188 LRLKQNRTATNHKAGNPFKE---MLKAFSNPlAILLFSTSTVTFIILYGAFLTFLPFHLNTSFQATALQIGLISAFMSFT 264
Cdd:cd17333 169 LTLFPELPSARNPQQSVGAFsasASRLLRNP-SIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 265 SAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEENRAAfIS 344
Cdd:cd17333 248 ITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKG-TS 326
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 355396663 345 LNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMA 385
Cdd:cd17333 327 VLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIF 367
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
17-374 |
3.55e-10 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 61.09 E-value: 3.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 17 ENLYMVFAVTLLSVLGVASVTPAFPQIAEFFGISPAK-----TGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLL 91
Cdd:PRK09874 14 RNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSalnmwSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 92 FGVSGGLCALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKyRTEAMGYNSSVLGIGTATYPAIGGLLS-MFGWR 170
Cdd:PRK09874 94 MGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNK-SGWALGTLSTGGVSGALLGPLAGGLLAdSYGLR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 171 YPFLLPFAAIPVALWITLR-LKQNRTATNHKAGNPFKEMLKAFSNPLAILLFSTSTVTFIILYGA---FLTFLPFHLNTS 246
Cdd:PRK09874 173 PVFFITASVLFLCFLVTLFcIRENFQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSiapILTLYVRELAGN 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 247 FQATALQIGLISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTL 326
Cdd:PRK09874 253 VSNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLPAV 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 355396663 327 MTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVF 374
Cdd:PRK09874 333 QTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVF 380
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
39-188 |
1.58e-09 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 59.12 E-value: 1.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 39 AFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIG 118
Cdd:cd17359 23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 119 ASALNSLNITIIGDLYKEKYRTEAMGYN--SSVLGIGTA-------TYPAIGGLLSMFGWRYPFLLpfAAIP-VALWITL 188
Cdd:cd17359 103 VGGASALVPMYIAEVAPAEIRGRLVSLNqlMIVFGQLLAyivnyliANAGGADWLGAEGWRWMLGL--EAIPaILFLLGM 180
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
19-380 |
1.76e-09 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 58.82 E-value: 1.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 19 LYMVFAVTLLSVLGVASVTPAFPQIAEFFGISPAKT------------------------------GLVVSSFTIPGLVA 68
Cdd:cd17389 1 ITIVFLALLLDLLAFTIILPLFPSLLDYYGQNDDSGlyslqissvdwfrdaigapderrynsvlfgGLIGSLFSLLQFLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 69 TPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIgASALNSLNITIIGDLYKEKYRTEAMGYNSS 148
Cdd:cd17389 81 SPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGI-SKGNVSLSTAIVADVTSPKKRSKGMALIGV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 149 VLGIGTATYPAIGGLLSMFGWRY---PFLLP-----FAAIPVALWITLRLKQNRtatnhkagnPFKEMLKAFSNPLAILL 220
Cdd:cd17389 160 AFSLGFIIGPMIGAYFASFTRSLgevFFSMPalfalVLALADLLFIFFFLPETL---------PSNLRRLGLVYFLYLFL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 221 FSTSTVTfiilygafLTFLPFHlntSFQATALQIGLISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALI--- 297
Cdd:cd17389 231 FSGLEFT--------LTFLTHQ---RFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPGKEKKAVLQGLILLIPAFLlig 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 298 IALNLPNCLSALIpagLIGAAQGLNMPTLMTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSG 377
Cdd:cd17389 300 WASSVTVLYAGLF---LYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLAGSEACYTIG 376
|
...
gi 355396663 378 AIL 380
Cdd:cd17389 377 ALL 379
|
|
| OATP |
pfam03137 |
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ... |
47-305 |
2.03e-09 |
|
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.
Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 59.14 E-value: 2.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 47 FGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALsRSFNELLMMRVLQGIGASALNSLN 126
Cdd:pfam03137 31 FGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLGSLLFAL-PHFLSFFLGQLLLGIGGTPIYTLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 127 ITIIGDLYKEKyrteamgyNSSV-LGIGTATY---PAIG-----GLLSMFG--------------------WRYPFLLPF 177
Cdd:pfam03137 110 ISYIDDNVKKK--------NSPLyLGILYAVRvlgPALGfllgsLCLRIYVdigkvsitltpkdprwvgawWLGFLIAGL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 178 AAIPVALWITL-----------------------RLKQNRTATNHKAGNPFKEMLKA----FSNPLaILLFSTSTVTFII 230
Cdd:pfam03137 182 LLLLTAIPFFFfpkslpgaakrrakkkkephsqdIADLKKTKSLKKLGPSLKDFPKAlkrlLKNPV-YMLLTLASVFEFL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 231 LYGAFLTFLPFHLNTSFQATALQIGLISAFMSFTSAVVAFNMKG--ISKA-LSERYRLFLAFI--LYCLALIIALNLPNC 305
Cdd:pfam03137 261 LIAGYATFLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGliIKKFkLSAKGLAKFNVItsLVSLLLSLLLFFLGC 340
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
23-344 |
3.72e-09 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 58.11 E-value: 3.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 23 FAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFtIPGLVATPLL-GLLADRYGRKKVLVPCLLLFGVSGGLCAL 101
Cdd:PRK10473 9 FALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVY-LAGMAAAMLFaGKIADRSGRKPVAIPGAALFIIASLLCSL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 102 SRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGL-LSMFGWRYPFLLPFA-A 179
Cdd:PRK10473 88 AETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLiMLKFPWQSLFYTMAAmG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 180 IPVALWITLRLKQNRTATNHKAGNPFKEMLKAFSNPLAI--LLFSTSTVTFIILYgafLTFLPFHLNTSFQATALQIGLI 257
Cdd:PRK10473 168 ILVLLLSLFILKETRPARAPAASSKPRENSESLLNRFFLsrLVITTLSVTVILTF---VNTSPVLLMEQMGFSRGEYAII 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 258 SAFMSFTSAVVAFNMKGISKALSERYRLFLAFILY-CLALIIALNLPNCLSaLIPAGLIGAaqGLNMPTLMTMITNIAPE 336
Cdd:PRK10473 245 MALTAGVSMTVSFSTPFALGIFKPRTLMLTSQVLFlAAGITLALSPSHAVS-LFGITLICA--GFSVGFGVAMSQALGPF 321
|
....*...
gi 355396663 337 ENRAAFIS 344
Cdd:PRK10473 322 SLRAGVAS 329
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
2-188 |
5.09e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 57.56 E-value: 5.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 2 TSGIDNARKRTVLKDENLYMVFAVTLLSVLGVASVTPAF-PQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYG 80
Cdd:cd17324 183 GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLaPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGG 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 81 RKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKyRTEAMGYNSSVLGIGTATYPAI 160
Cdd:cd17324 263 RRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAAL 341
|
170 180
....*....|....*....|....*....
gi 355396663 161 GGL-LSMFGWRYPFLLPFAAIPVALWITL 188
Cdd:cd17324 342 GGLvLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
56-388 |
5.78e-09 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 57.21 E-value: 5.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 56 LVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYK 135
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 136 EKYRTEAMGYNSSVLGIGTATYPAIGGLLSMFGWRYPFL-LPFAAIPVALWITLRlkqnRTATNHkagnpfkemlkafsn 214
Cdd:cd17317 109 PKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAIsLPGLLFLLLLWWLPR----RTIIVG--------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 215 plaILLFSTSTVTFIILYGAflTFLPFHLNTSFqatalqigLISAFMSFTSAVVAFNMKgisKALSERYRLFLAFILYCL 294
Cdd:cd17317 170 ---LIWFVTSLVYYGLSLNS--SNLGGNLYLNF--------FLSGLVEIPAYFLALLLL---DRLGRRWTLSGSLLLAGL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 295 ALIIALNLPNCLS------ALIPAGLIGAAQGLnMPTLMTMITniaPEENRAAFISLNSMSLRLGQTLGPFL--MGGIYS 366
Cdd:cd17317 234 ACLVTALLPDDENtlaltlALVGKFAISAAFSV-IYLYTAELY---PTVVRNTGVGLCSTVARVGAILAPFIvlLGKIGP 309
|
330 340
....*....|....*....|..
gi 355396663 367 LFGIrSVFSSGAILAAVMASVL 388
Cdd:cd17317 310 LLPL-IIFGVLALLGGLLTLLL 330
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
36-264 |
6.13e-09 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 57.40 E-value: 6.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 36 VTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQ 115
Cdd:PRK03893 39 ITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVI 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 116 GIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLL-SMFGWRYPFLLPFAAIPVALWITLRLK--- 191
Cdd:PRK03893 119 GMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVvPVWGWRALFFIGILPIIFALWLRKNLPeae 198
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 355396663 192 --QNRTATNHKAGNPFKEMLKAFSNPLAILLfstSTVTFIILYgafltfLPFHLNTSFQATALQIGLISA--FMSFT 264
Cdd:PRK03893 199 dwKEKHAGKAPVRTMVDILYRGEHRIINILL---TLAAAAALW------FCFAGNLQNAAIVAVLGLLCAaiFISFM 266
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
27-188 |
9.56e-09 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 56.50 E-value: 9.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 27 LLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPglVATPLL--GLLADRYGRKKVLVPCLLLFGVSGGLCALSRS 104
Cdd:cd17476 8 LLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLT--VGTFILifGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 105 FNELLMMRVLQGIGASALNSLNITIIGDLYKE-KYRTEAMGYNSSVLGIGTATYPAIGGLLSMFGWrYPFLLPFAAIPVA 183
Cdd:cd17476 86 FIFFIICRALQGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAW-WPWIFWFLAILAA 164
|
....*
gi 355396663 184 LWITL 188
Cdd:cd17476 165 IVAVA 169
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
11-168 |
9.71e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.83 E-value: 9.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 11 RTVLKDENLYMVFAVTLLSVLGVASVTPAFPQIAEF-FGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCL 89
Cdd:COG2211 222 KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 90 LLFGVSGGLCALSRSFNELLMM--RVLQGIGASALNSLNITIIGDL-----YKEKYRTEA--MGYNSSVLGIGTATYPAI 160
Cdd:COG2211 302 LLAALGLLLLFFLGPGNLWLLLvlAALAGIGLGAILVLPWAMLADVvdydeWKTGRRREGlyFGIFTFAIKLGQALAGAL 381
|
....*....
gi 355396663 161 GG-LLSMFG 168
Cdd:COG2211 382 AGlLLALFG 390
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
71-385 |
1.74e-08 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 55.74 E-value: 1.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 71 LLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNE--------LLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEA 142
Cdd:TIGR00883 54 VFGHFGDRIGRKKTLVITLLMMGIGTLLIGLLPSYATigiwapilLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFY 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 143 MGYNSSVLGIGTATYPAIGGLLSMF---------GWRYPFLLPFAAIPVALWITLRLKQN-----RTATNHKAGNPFKEM 208
Cdd:TIGR00883 134 GSFQQVGAPVGLLLAALTVLLLSYLlgddallewGWRIPFLVSAVLVLIGLYLRRNLEETpvfekAQEKHKKKRGPIAET 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 209 LKAFSNPLAILLFSTSTVTfiILYGAFLTFLPFHLNTSFQATAlqigLISAFMSFTSAVVAFNMKGISKALSERY--RLF 286
Cdd:TIGR00883 214 LTKHRKPFLLGLGLVIATT--TTFYLITTYLPTYLTQTLGLSA----NSALLVLMLSLILFFITIPLSGALSDRIgrRPV 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 287 L------AFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEENRAAFISLN-SMSLRLGQTLGPF 359
Cdd:TIGR00883 288 LiiftvlAALLAVPLLMALLDSGSFTLFFFLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAyNLAGAIFGGFAPY 367
|
330 340
....*....|....*....|....*.
gi 355396663 360 LMGGIYSLFGIRSVFSSGAILAAVMA 385
Cdd:TIGR00883 368 IAAALVAMTGDWYAIGYYLAALALIG 393
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
15-196 |
1.78e-08 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 55.68 E-value: 1.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 15 KDENLYMVFAVTLLSVLGVASVT---PAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLL 91
Cdd:PRK11652 3 RQRNVNLLFMLVLLVAVGQMAQTiyvPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 92 FGVSGGLCALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLS-MFGWR 170
Cdd:PRK11652 83 FILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTtLFGWR 162
|
170 180
....*....|....*....|....*...
gi 355396663 171 --YPFLLPFAAIpVALWITLRLKQNRTA 196
Cdd:PRK11652 163 acYLFLLLLGAG-VTFSMARWMPETRPA 189
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
47-390 |
1.88e-08 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 55.71 E-value: 1.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 47 FGISPAKTGLVVSSFTIPGLVATPLLGLLADR----YGRKK--VLVPCLL------LFGVSG----GLCALSRSFNELLM 110
Cdd:cd17313 29 LGLSHALIGFVWTLGPILGLFVQPLVGSLSDRcnsrIGRRRpfILVGAPLaalgliLIPNAAdiglALGDGPRTWALVLF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 111 M--RVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSMFGW---------RYPFLLPFAA 179
Cdd:cd17313 109 VlgIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWfgfalggnlKVPFYIGAII 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 180 IPVALWITL--------RLKQNRTATNHKAGNPFKEMLKAFSNP--------LAILLFSTSTVTFIILYGAFLTFLPFHl 243
Cdd:cd17313 189 LLVCVLVTLffvkepplSPEAGEHSENPSLGEVLKSLLKLLKIMprsllrllLVIFFWWIAFFPFELFFTDYMGEEVYH- 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 244 NTSFQATALQIG-----LISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAA 318
Cdd:cd17313 268 GTSAASSHYGAGvrmgaWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIG 347
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 355396663 319 QGLNMPTLMTMITNIAPEENR--AAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYF 390
Cdd:cd17313 348 WATININPYPLVSDYHSESGRgqGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGALF 421
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
27-320 |
1.97e-08 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 55.67 E-value: 1.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 27 LLSVLGVASVT---PAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSR 103
Cdd:PRK11043 13 GLSMLGFLATDmylPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 104 SFNELLMMRVLQGIGASALNSLNITIIGDLYKEKyrtEAMGYNSSVL---GIGTATYPAIGG-LLSMFGWRYPFLLPFAA 179
Cdd:PRK11043 93 SAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQ---KANRVFATIMplvALSPALAPLLGAwLLNHFGWQAIFATLFAI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 180 IPVALWITLRLKQNRTATNHKAGNP-FKEMLK--AFSNPLAIllFSTSTVTFIilygAFLTFLPFHL-NTSFQATAlqIG 255
Cdd:PRK11043 170 TLLLILPTLRLKPSKKARKQSQDALtFKQLLKskTYLGNVLI--FAACSAAFF----AWLTGSPFILeQMGYSPAD--IG 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 355396663 256 LisafmSFTSAVVAFNMKGI-SKALSERYR-------LFLAFILYCLALIIA--LNLPNCLSALIPAGLIGAAQG 320
Cdd:PRK11043 242 L-----SYVPQTIAFLVGGYgCRAALQKWGgeqllpwLLVLFAVSVIAIWLAslLSHPSLVPLLIPFCVMAAANG 311
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
54-175 |
2.54e-08 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 55.35 E-value: 2.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 54 TGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGASALNSLNITIIGDL 133
Cdd:cd17391 242 SGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKI 321
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 355396663 134 YKEKYRTEAMGYNSSVLGIGTATYPAIGGLLS-MFGWRYPFLL 175
Cdd:cd17391 322 TPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAaHFGYRAVFVV 364
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
21-364 |
2.89e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 55.32 E-value: 2.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 21 MVFAVTLLSvLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCA 100
Cdd:cd17475 1 ATLAQAAAS-LVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 101 LSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTA----TYPAIGGLlsmFGWRYPFLLP 176
Cdd:cd17475 80 LVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGAlaaaLLPPLALH---YGWRAAFVVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 177 FAAI---PVALWITLRLKQNRTATNHKAGNPFKEMLKAFSNPlAILLFSTSTVTFIILYGAFLTFLPFHLNTSFQATALQ 253
Cdd:cd17475 157 GLVSilaAVLFWLFYREPPAASAATESASTLLRSLKEVLRNR-DVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 254 IGLISAFMSFTSAVVAFNMKGISKALSERYR----LFLAFILYCLALIIALNLPNCLSALIPAGLIG---AAQGLNMPTL 326
Cdd:cd17475 236 AGALLAVAQLGGALGRIGLGRVSDRVFGGRRrpvlVITAAIAAAALLVLSLLSPGTPLWLLVLLLILlglFAIGWNGLYL 315
|
330 340 350
....*....|....*....|....*....|....*...
gi 355396663 327 mTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGI 364
Cdd:cd17475 316 -TLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLL 352
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
218-385 |
3.80e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.88 E-value: 3.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 218 ILLFSTSTVTFIILYGAFLTFLPFHLNTSFQATALQIGLISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALI 297
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 298 IALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSG 377
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLIL 170
|
....*...
gi 355396663 378 AILAAVMA 385
Cdd:COG2271 171 GLPGLLLA 178
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
19-184 |
7.54e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 53.74 E-value: 7.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 19 LYMVFAVTLLSVLGVASVTPafpQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVS-GG 97
Cdd:cd17365 176 LWVTFFMGLLLVYLLNSWLP---KLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSlAL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 98 LCALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSMFGWRYPFLLPF 177
Cdd:cd17365 253 LGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLA 332
|
....*..
gi 355396663 178 AAIPVAL 184
Cdd:cd17365 333 LAIPAAL 339
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
40-300 |
7.77e-08 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 54.07 E-value: 7.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 40 FPQIaeFFGISPAKTGLVVS--SFTIpGLVATPLLGLLA----DRYGRKKVLVPCLLLFGVSGGLCALSRSFNE------ 107
Cdd:cd17369 29 FNKL--FFPAVDPAAGTLAAfaTFGV-GFLARPLGGVVFghfgDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQigilap 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 108 --LLMMRVLQGIGASALNSLNITIIGDLYKEKYRteamGYNSSVLGIG--------TATYPAIGGLLS-----MFGWRYP 172
Cdd:cd17369 106 ilLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRR----GFYGSFPQLGapvglllaTGVFLLLSALLSdeaflSWGWRIP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 173 FLLPFAAIPVALWITLRLK-----QNRTATNHKAGNPFKEMLKAFSNP--LAILLFSTSTVTFIILYGAFLTFLPFHLNT 245
Cdd:cd17369 182 FLLSAVLVAVGLYIRLRLEetpvfRRAKEAGQVVRAPLVEVLRRHWRAllLAIGLRLAENVLFYLFTTFALSYATQTLGV 261
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 355396663 246 SfQATALQIGLIsafmsftSAVVAFNMKGISKALSERY---RLFLAFILYCLALIIAL 300
Cdd:cd17369 262 D-RSTVLLAVLI-------ASVVAAITIPLFGWLSDRVgrrPVYLAGALLAALFAFPF 311
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
22-385 |
8.27e-08 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 53.80 E-value: 8.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 22 VFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCAL 101
Cdd:cd17393 4 VAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 102 SRSFNELLMMRVLQGIGASALNSLnITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSMFGW-RYPFLLPFAAI 180
Cdd:cd17393 84 APSVPALALALFLFGAANGALDVA-MNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVsPGVHLLAAAVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 181 P-VALWITLRLKQNRTATNHKAGNPFKEMLKAFSNPLAILLFSTSTVTFIILYGAFLTFLPFHLNTSFQATALQIGLISA 259
Cdd:cd17393 163 LlLAALVAIRALLPGTGEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 260 FMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNiAPEENR 339
Cdd:cd17393 243 VFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGA-LPGLAA 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 355396663 340 AAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMA 385
Cdd:cd17393 322 GIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVA 367
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
36-118 |
2.36e-07 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 52.19 E-value: 2.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 36 VTPAFPQIAEFFGI--SPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRV 113
Cdd:cd17315 16 INGALLYIAKDLGFglSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRF 95
|
....*
gi 355396663 114 LQGIG 118
Cdd:cd17315 96 LLGLG 100
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
58-369 |
2.64e-07 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 52.46 E-value: 2.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 58 VSSFTIpgLVATPLLGLLADRYGRKKVLvpcLLLFGVSGGLCALSRSFNE------LLMMRVLQGIGASALNSLNITIIG 131
Cdd:COG2270 60 IAGLLV--ALLAPVLGAIADRSGRKKPF---LAFFTLLGVLATAALFFVApgglwlGLLLFVLANIGFEGSLVFYNAFLP 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 132 DLYKEKYRTE------AMGYNSSVLG-----IGTATYPAIGGLLSMFGWRYPFllPFAAIP---VALWITLRLKQNRTAT 197
Cdd:COG2270 135 DIATPEEIGRvsglgwALGYLGGVLLllinlALFLKPEAFGLPDAGEAVRISF--LLTALWwllFALPLFLFLPERPRPG 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 198 NHKAGNPFKEMLKAFSNPLAILLFSTSTVTFIILY-------GAFLTFLPFHLNTSFQATALQIGLISAFMSFTSAVVAF 270
Cdd:COG2270 213 PAPPRGAVRAGFRELRRTLRELRRYRDLLRFLLAYffyrdgvQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGAL 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 271 NMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEENRAAFISLNSMSL 350
Cdd:COG2270 293 LFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGLYALSG 372
|
330
....*....|....*....
gi 355396663 351 RLGQTLGPFLMGGIYSLFG 369
Cdd:COG2270 373 KAASFLGPLLFGLVTQLTG 391
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
21-303 |
4.63e-07 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 51.47 E-value: 4.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 21 MVFAVTLLSVLGVASVTPAFPQIA---EFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGG 97
Cdd:cd17336 4 FVVLLCLLGLLQGAVVSYFVSTITtieKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGCF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 98 LCALSRSFnelLMMRVLQGIGASALNSLNITIIGDLYKEKyrteamgyNSSV-LGIGTATY---PAIGGLLSMFGWRYPF 173
Cdd:cd17336 84 LLALPHFL---FVGQFLLGIGSSPLYTLGITYIDDNVSKK--------NSPLyIGILYAMRvlgPALGFLLGSFLLRIYV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 174 LLPFAAIPV---------ALWITLRLkqnrtatnhkagnpFKEMLKAFSNPLA----ILLFSTSTVTFIIL-YGAFLTFL 239
Cdd:cd17336 153 DFSRVPLGItpddprwigAWWLGFLI--------------LGILLLIVSIPLFffppIFILLLLAIVFESFaISGFSTFL 218
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 355396663 240 PFHLNTSFQATALQIGLISAFMSFTSAVVAFNMKG-ISKALSERYRLFLAFILYCLALIIALNLP 303
Cdd:cd17336 219 PKYLETQFRLSASLASLLTGLILVPGAALGILLGGlIIKKFKLTARGLAKFVLILSLLSVILYIS 283
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
14-175 |
6.09e-07 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 51.16 E-value: 6.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 14 LKDENLYMVFAvtllsvlgvasvtpafPQIAEFFGiSPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFG 93
Cdd:cd17383 9 LLDNMLYMVIV----------------PIIPDYLN-EDIAIGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMF 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 94 VSGGLCALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKY-RTEAMGYNSSVLGIGTATYPAIGGLLSMF-GWRY 171
Cdd:cd17383 72 LSTAVFAFGESYAVLFFARSLQGVGSAFADTAGLAMIADRFTEEAeRSKALGIALAFISFGCLVAPPFGGILYEFaGKEV 151
|
....
gi 355396663 172 PFLL 175
Cdd:cd17383 152 PFLI 155
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
40-190 |
7.66e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 50.65 E-value: 7.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 40 FPQIAE-FFGISPAKTGLVVSSFTIPGLVATPLLG-LLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGI 117
Cdd:cd17474 221 LPFLLElLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGL 300
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 355396663 118 GASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSM-FGWRYPFLLPFAAIPVALWITLRL 190
Cdd:cd17474 301 GLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEiFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
52-388 |
8.16e-07 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 50.78 E-value: 8.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 52 AKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGASALNSLNITIIG 131
Cdd:TIGR00898 127 WKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNT 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 132 DLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSmfGWRYPFL---LPFAAIPVALWI----------------TLRLKQ 192
Cdd:TIGR00898 207 EFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIP--DWRWLQLavsLPTFLFFLLSWFvpesprwlisqgrieeALKILQ 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 193 NRTATNHKA-------GNPFKEMLKAFSNPLAILLFSTST---VTFIILYGAFLTF-----LPFHLnTSFQATALQIGLI 257
Cdd:TIGR00898 285 RIAKINGKKlpaevlsLSLEKDLSSSKKQYSFLDLFRTPNlrkTTLCLMMLWFTTAfsyygLVLDL-GNLGGNIYLDLFI 363
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 258 SAFMSFTSAVVAFNMkgISKaLSERYRL---FLAFILYCLALI-IALNLPNCLSALIPAGLIGAAQGLNMPTLMTmiTNI 333
Cdd:TIGR00898 364 SGLVELPAKLITLLL--IDR-LGRRYTMaasLLLAGVALLLLLfVPVDLYFLRTALAVLGKFGITSAFQMVYLYT--AEL 438
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 355396663 334 APEENRAAFISLNSMSLRLGQTLGPFL-MGGIYSLFGIRSVFSSGAILAAVMASVL 388
Cdd:TIGR00898 439 YPTVVRNLGVGVCSTMARVGSIISPFLvYLGEKWLFLPLVLFGGLALLAGILTLFL 494
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
29-173 |
1.46e-06 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 50.32 E-value: 1.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 29 SVLGVASVTPAFPQIAEFFGISPAkTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVpCLLLFGVSGGL-CALSRSFNE 107
Cdd:cd06179 10 QLFGVTLPAAVLPFIVADLGPSSN-STWISTAWSLAQAVLGPIVGRLSDLFGRRWFFI-GGNLLGVVGSIvAGTAKSVNM 87
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 355396663 108 LLMMRVLQGIGASALNSLNItIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLL---SMFGWRYPF 173
Cdd:cd06179 88 LIGGQALIGIGAGTQGLGAA-VASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALveaNAAGWRWIF 155
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
41-303 |
1.87e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 49.56 E-value: 1.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 41 PQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGV-SGGLCALSRSFNELLMMRVLQGIGA 119
Cdd:cd17341 23 PVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIpLLALALAVSSYWGLLVLGFLLGFAG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 120 SALNSlNITIIGDLY-KEKYRTEAMGY----NSSVLGIGTAT---YPAIGGLLSMFGWRYPFLLPFAAIPVALWITLRLK 191
Cdd:cd17341 103 ANFAS-GQPWASFWFpKEKIGGAAGGIagagNMGVAVSQLLApliAGAIVFDGGFVGWRNAFFVPGILLAIAAVLVLLFG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 192 QNRTATNHKAGNPFKEMLKAFSNPLAILLFststVTFIILYGAFLTF---LPFHLNTSFQATALQIGLISAFMSFTSAVv 268
Cdd:cd17341 182 DDLPTGKASALEFLKVQLAVLKNYRTWILS----LLYGVTFGSFVGFsnvLPTYFKTRFGLPLVTAGILAALFPLAGAL- 256
|
250 260 270
....*....|....*....|....*....|....*....
gi 355396663 269 afnMKGISKALSERY----RLFLAFILYCLALIIALNLP 303
Cdd:cd17341 257 ---ARPAGGWLSDRFggrrRLWWLFIVMTIGAALLSLSL 292
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
56-361 |
2.14e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 49.55 E-value: 2.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 56 LVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYK 135
Cdd:cd17327 45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 136 EKYRTEAMGYNSSVLGIGtatyPAIGGLLS-----------MFGWRYPFLLP-FAAIPVALWITL--------------- 188
Cdd:cd17327 125 REEQAKRIAFFYAAAGLG----SIFGGLLAygvfkilgvggLAGWRWLFIIEgLITIIIGLVIFFwlpdnpskawfltee 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 189 --RLKQNRTATNHKAG----NPFKEMLKAFSNPLAILLFSTSTVTFIILYGAFlTFLPFHLNtSFQATALQIGLISAFMS 262
Cdd:cd17327 201 ekELAVERLRANQTGKgdqkFKWKQIKEAFKDPRTWLLFLFFFCSQITNNGIS-NFLPLILK-SLGFYSLQTNLLSVPIG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 263 FTSAVVAFnmkgISKALSER--YRLFLAFILYCLAL---IIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNI-APE 336
Cdd:cd17327 279 ALGAVSLL----IAALLSDRfkKRGLFAIFACVLALvgsIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNcAGY 354
|
330 340
....*....|....*....|....*
gi 355396663 337 ENRAAFISLNSMSLRLGQTLGPFLM 361
Cdd:cd17327 355 TKRATVLAIMLIFYNVGNIVAPQIF 379
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
19-188 |
2.25e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 49.35 E-value: 2.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 19 LYMVFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRY-GRKKVLVPCLLLFGVSGG 97
Cdd:cd06174 206 WLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLA 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 98 LCALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLS--MFGWRYPFLL 175
Cdd:cd06174 286 LLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaaTFGLTGAFLV 365
|
170
....*....|...
gi 355396663 176 PFAAIPVALWITL 188
Cdd:cd06174 366 LAVLLLLAAILLL 378
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
50-396 |
2.55e-06 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 49.36 E-value: 2.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 50 SPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSR-----SFNELLMMRVLQGIGASALNS 124
Cdd:pfam05977 43 SPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTLLTLLAglgllSPWLLLGLTFLGGIGTALMDP 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 125 LNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGG-LLSMFGWRYPFL---LPFAAIPVALWITLRLKQNRTATNHK 200
Cdd:pfam05977 123 AWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGvLLAAFGPAFTFAlnaLSYFAVIAALWRWKRAAPASPLPRER 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 201 AGNPFKEMLK--AFSNPLAILLfsTSTVTFIILYGAFLTFLPFHLNTSFQATALQIGLISAFMSFTSAVVAFNMKGISKA 278
Cdd:pfam05977 203 IFGAVRAGLRftAMSRELRSVL--VRAFAFGLSASAVWALLPLVARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRER 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 279 LSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEENRAAFISLNSMSLRLGQTLGP 358
Cdd:pfam05977 281 LGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLLLGGAAWITALTTLNVAVQLSVPRWVRGRALAVYQTVFFGGMAAGS 360
|
330 340 350
....*....|....*....|....*....|....*....
gi 355396663 359 FLMGGIYSLFGIR-SVFSSGAILAAVMASVLYFALKPTQ 396
Cdd:pfam05977 361 WLWGAVAEALSVTgALLGAAAALLAGAAAGLRFRLPEGE 399
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
232-396 |
3.76e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 48.38 E-value: 3.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 232 YGAFLTFLPFHLNTSFQATALQIGLISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIP 311
Cdd:cd17329 15 FFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 312 AGLIGAAQGLNMPTLMTMITNIAPEENRAAFISLNSMSLRLGQTLGPfLMGGIYSLFGIRSVFSSGAILAAVMASVLYFA 391
Cdd:cd17329 95 LVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGP-LLGGLLLLYSFRLLFLAAAVLFLLAALVLLFL 173
|
....*
gi 355396663 392 LKPTQ 396
Cdd:cd17329 174 LPETR 178
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
54-188 |
4.40e-06 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 48.42 E-value: 4.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 54 TGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALS---RSFNELLMMRVLQGIGASALNSLNITII 130
Cdd:pfam00083 48 SGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYI 127
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 355396663 131 GDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSMF----GWRYPFLLPFA-AIPVALWITL 188
Cdd:pfam00083 128 SEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTsnsdGWRIPLGLQLVpALLLIIGLLF 190
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
36-212 |
7.46e-06 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 47.63 E-value: 7.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 36 VTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQ 115
Cdd:PRK15402 32 IQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQ 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 116 GIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGG-LLSMFGWRYPFLLpFAAIPVALWITLRLKQNR 194
Cdd:PRK15402 112 GIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAaLIHVLPWRGMFVL-FAALAALSFFGLWRAMPE 190
|
170
....*....|....*...
gi 355396663 195 TATNHKAGNPFKEMLKAF 212
Cdd:PRK15402 191 TAGRVGEKLSLKELGRDY 208
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
55-390 |
8.09e-06 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 47.57 E-value: 8.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 55 GLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGASALNSLNITIIGDLY 134
Cdd:cd17384 34 GLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMLASLY 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 135 -KEKYRTEAMGYNSSVLGIGTATYPAIGGLLSMF-GWRYPFLL--PFAAIPVALWITLrLKQNRTATNHKAGNPFKEMLK 210
Cdd:cd17384 114 pDDKERGKAMGIALGGLALGVLVGPPFGGVMYEFvGKSAPFLIlaFLALLDGALQLFI-LQPSVKSEESEEGTPWKTLLK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 211 afsNPLAIL-----LFSTSTVtfiilygAFL-TFLPFHLNTSFQATALQIGLIsafmsFTSAVVAF----NMKGISKALS 280
Cdd:cd17384 193 ---DPYILIaagaiCFSNSGI-------AILePCLPIWMMETMCPPKWQLGTA-----FLPDSIGYligtNLFGPLAHKI 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 281 ERYR-LFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGL---NMPTLMTMITNIAPEENRAAFISLNSMSLRLGQTL 356
Cdd:cd17384 258 GRWLcSLLGMLLVGISLILIPLAKNIYGLIIPHFGLGLGIGMvdsSMMPLLAYLVDLRHSSVYGSVYAIADVAFCLAFAL 337
|
330 340 350
....*....|....*....|....*....|....
gi 355396663 357 GPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYF 390
Cdd:cd17384 338 GPSLGGAIVKSIGFPWLMRIIGIINILYAPLLFF 371
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
23-383 |
1.10e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 47.16 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 23 FAVTLLSVLGVASVTPAFPQ-IAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADR-YGRKKVLVPCLLLFGVSGGLCA 100
Cdd:cd17471 2 LLATLLTGLAGAFVLPYLSLfLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 101 LSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNS---SVLGIGTATYPAIGGLLSM-FGWRYPFLLP 176
Cdd:cd17471 82 FLRNYWVLLLVGVVLLSLGAAAFPQLFALAREYADRSSGRDATLFNSvlrAAFSLAWVIGPPLAFLLLDvLGFTGLFLLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 177 FAAIPVALWITLRLKQNRTATNHKAGNPFKEMlKAFSNPLAILLFststVTFIILYGA---FLTFLPFHLNTSFQATALQ 253
Cdd:cd17471 162 ALLYLVVALLVLFLLPSVKPPAQKATPASSLV-KAPVNRRLLLLF----AAFTLLFAAnsmYIIAMPLYVTNELGGSESW 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 254 IGLIsafMSFTSAVVAFNMKGiSKALSERY---RLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQ-GLNMPTLMTM 329
Cdd:cd17471 237 VGLL---FGLAAALEIPIMLL-AGLLAKRFgkrRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFiGITAGLGISY 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 355396663 330 ITNIAPEENRAAfISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAV 383
Cdd:cd17471 313 FQDLMPGQPGLA-TTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALL 365
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
40-175 |
1.14e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 47.16 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 40 FPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYG-RKKVLVPCLLLFGvSGGLCALSRSFNELLM-MRVLQGI 117
Cdd:cd17352 26 FVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGcRPVAIAGGLLAAL-GLLLSSFATSLWQLYLtYGVLGGL 104
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 355396663 118 GASALNSLNITIIGdLYKEKYRTEAMGYNSSVLGIGTATYPAIGG-LLSMFGWRYPFLL 175
Cdd:cd17352 105 GLGLIYSPAIVIVG-QYFEKKRGLATGIAVAGSGVGTFVFPPLLRyLLDNYGWRGALLI 162
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
50-189 |
1.18e-05 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 46.90 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 50 SPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGASALNSLNITI 129
Cdd:cd17374 33 SQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLIL 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 355396663 130 IGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSmfGWRYPFL---LPFAAIPVALWITLR 189
Cdd:cd17374 113 GTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIR--DWRLLQLvvsVPFFLFFLYSWWLPK 173
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
71-289 |
1.57e-05 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 46.52 E-value: 1.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 71 LLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNE--------LLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEA 142
Cdd:cd17367 59 LFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATigiwapiiLLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFY 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 143 MGYNSSVLGIGTATYPAIGGLLSMF---------GWRYPFLLPFAAIPVALWITLRLK-----QNRTATNHKAGNPFKEM 208
Cdd:cd17367 139 SSFQYVTLIGGQLLALGVLLVLQHTlgedqmaawGWRIPFLLGGVLAVVVLWLRRGLEetesfEAIAESNEASAGTLREL 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 209 LKafsNPLAILLFSTSTVTFIILYGAFLTFLPFHLNTSFQATALQIGLIsafmSFTSAVVAFNMKGISKALSERY---RL 285
Cdd:cd17367 219 RR---HPRELLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWI----TTAALLVFMLLQPLGGRLSDRIgrrPL 291
|
....
gi 355396663 286 FLAF 289
Cdd:cd17367 292 LLFF 295
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
39-175 |
1.71e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 46.39 E-value: 1.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 39 AFPQIAEFFGISPAKTGLVVSSFTIpGLVATPLL-GLLADRYGRKKVlvpclLLFGVSG-GLCAL------SRSFNELLM 110
Cdd:cd17380 21 AIVPMAKEFGWSKTDQGLVLSSFFW-GYALTQVLgGYLADRFGGKKV-----LLLAVALwSLATLltpllaYSSLPLLIL 94
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 355396663 111 MRVLQGIG-ASALNSLNiTIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGG-LLSMFGWRYPFLL 175
Cdd:cd17380 95 SRILLGLGeGVHFPSMT-SLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPlLLEYYGWPSVFYF 160
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
22-397 |
1.97e-05 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 46.51 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 22 VFAVTLLSVLGVASVTPAFP-QIAEFFGiSPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLvpcLLLFGVSG---- 96
Cdd:PRK10489 22 VFIARFISIFGLGLLGVAVPvQIQMMTG-STLQVGLSVTLTGGAMFIGLMVGGVLADRYDRKKLI---LLARGTCGlgfi 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 97 GLCALSRSFN-ELLMMRVLQ-------GIGASALNSLNITIIGdlyKEKyrTEAMGYNSSVLG-IGTATYPAIGGLL--- 164
Cdd:PRK10489 98 GLALNAFLPEpSLLAIYLLGlwdgffgSLGVTALLAATPALVG---REN--LMQAGAITMLTVrLGSVISPALGGLLiaa 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 165 SMFGWRYpfLLPFAAIPVALWITLRLKQNRtATNHKAGNPFKEMLKAFSnplaiLLFSTSTVTFIILYGAFLTFL----- 239
Cdd:PRK10489 173 GGVAWNY--GLAAAGTFITLLPLLRLPALP-PPPQPREHPLRSLLAGFR-----FLLASPVVGGIALLGGLLTMAsavrv 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 240 --PFHLNTSFQATALQIGLISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGA 317
Cdd:PRK10489 245 lyPALADEVWQMGAAQIGLLYAAVPLGAALGALTSGWLAHSARPGLLMLLSTLGSFLAVGLFGLMPMWILAVLCLALFGY 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 318 AQGLNMPTLMTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYFALKPTQR 397
Cdd:PRK10489 325 LSAISSLLQYTLLQTQTPDEMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPVASASASGFGLLIIGVLLLLVLGELRR 404
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
33-391 |
2.01e-05 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 46.42 E-value: 2.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 33 VASVTPAFPQIAEFFGISPAKTGLVVssfTIPGL---VATPLLGLLADRYGRKKVLVPCLLLFGVSgglcALSRSFNE-- 107
Cdd:cd17339 15 ITSVGPLLPEIRDDLGLSASQAGLLT---TLPLLcfaVFSPLAPRLARRFGLERTLLLALLLLAAG----ILLRSLGGia 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 108 -LLMMRVLQGIGASALNSLNITIIGDlYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLS---MFGWRYPFLL--PFAAIP 181
Cdd:cd17339 88 lLFLGTALAGAGIAVGNVLLPSLIKR-DFPRRVGLMTGLYTTSMNLGAALASGLSVPLAqalGGGWRGALAIwaLPALLA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 182 VALWITLRLKQNRTATNHKAgnpfKEMLKAFSNPLA---ILLFSTSTVTFIILYGAFLTFLpfhlnTSFQATALQIGLIS 258
Cdd:cd17339 167 LLIWLPQLRRRKRAAAAAAP----LTKISVWRSPLAwqvTLFMGLQSLLFYTLMAWLPTIL-----IDAGLSAATAGWLL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 259 AFMSFTSAVVAFNMKGI-SKALSERYRLFLAFILYCLALIIALNLPNCLSALIpAGLIGAAQGLNMPTLMTMITNIAPEE 337
Cdd:cd17339 238 SLFQLVGIPASLLVPILaTRLKNQRPIVVLLAVLFIIGVLGLLFAPTALALLW-AVLLGLGGGAAFSLALTLISLRSSDP 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 355396663 338 NRAAfiSLNSMSLRLGQTL---GPFLMGGIYSLFG-IRSVFSSGAILAAVMASVLYFA 391
Cdd:cd17339 317 AEAA--ALSGMAQSVGYLLaalGPLLFGVLHDLTGsWTAPLVLLLALTVLQLVAGLGA 372
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
3-190 |
2.15e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 46.06 E-value: 2.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 3 SGIDNARKRTVLKDENLYMVFAVTLLSVLGVASVTPAFPQIA-EFFGISPAKTGLVVSSFTIPGLVATPLL-GLLADRYG 80
Cdd:cd17331 193 SVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAmDFFGLTPEENGYLMSYAGVLGMVVQGLLvGPLTKRFG 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 81 RKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGASALNslniTIIGDLYKEKYRTEAMGynsSVLGIGTATY--- 157
Cdd:cd17331 273 ERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLY----TVITSLLTKAVPPEDTG---TALGLSHALFslv 345
|
170 180 190
....*....|....*....|....*....|....*...
gi 355396663 158 ----PAIGG-LLSMFGWRyPFLLPFAAIPVALWITLRL 190
Cdd:cd17331 346 rtvsPTIGGaLLQAYGFP-SFGLLGAAINGLLTVYLLL 382
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
55-184 |
2.22e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 46.10 E-value: 2.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 55 GLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMM---RVLQGIGASALNSLNITIIG 131
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKSPELLifgRFLVGIACGLSTGFVPMYLQ 131
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 355396663 132 DLYKEKYRTeAMGYNSSVLGIGTATYPAIGGLLSMFGWRY--PFLLPFAAIPVAL 184
Cdd:cd17357 132 EISPSELRG-ALGSLTQIGVTLGILLGQVFGLPSVLGTETlwPYLLFFPGIPALL 185
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
216-390 |
2.53e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 45.57 E-value: 2.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 216 LAILLFSTSTVTFIILYGAFLTFLPFhLNTSFQATALQIGLISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLA 295
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 296 LIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFS 375
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172
|
170
....*....|....*
gi 355396663 376 SGAILAAVMASVLYF 390
Cdd:COG0477 173 INAPLGLLALVLRLR 187
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
11-155 |
2.56e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.87 E-value: 2.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 11 RTVLKDENLYMVFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLL 90
Cdd:pfam07690 194 WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALL 273
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 355396663 91 LFGVSGGLCALSRSFNELLMMR---VLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTA 155
Cdd:pfam07690 274 LLILAALGLLLLSLTLSSLWLLlalLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGA 341
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
47-262 |
4.51e-05 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 45.30 E-value: 4.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 47 FGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGASALNSLN 126
Cdd:PRK12307 48 LGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 127 ITIIGDLYKEKYRTEAMGYNSSVLGIGT--ATYpAIGGLLSMFGWRYPFLLPFAAIPVALWITLRLKQNRTATNHKAGNP 204
Cdd:PRK12307 128 STYAVESWPKHLKSKASAFLVSGFGIGNiiAAY-FMPSFAEAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLSGK 206
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 355396663 205 FKEMLKAFSNPLAILL-------FSTSTVTFIILYGAFLTFLPFH--LNTSFQATALQIGLISAFMS 262
Cdd:PRK12307 207 GKHSQSAWSVFSLSMKglfnraqFPLTLCVFIVLFSIFGANWPIFglLPTYLAGEGFDTGVVSNLMT 273
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
41-188 |
4.98e-05 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 44.83 E-value: 4.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 41 PQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGAS 120
Cdd:cd17372 23 PAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLG 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 355396663 121 AlNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGL-LSMFGWRYpfLLPFAAIPVALWITL 188
Cdd:cd17372 103 G-GPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLvMPRLGWRW--LLAFSSVPSSLLLVF 168
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
35-120 |
4.99e-05 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 45.04 E-value: 4.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 35 SVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVL 114
Cdd:cd17362 22 SITSPALSGTDWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLI 101
|
....*.
gi 355396663 115 QGIGAS 120
Cdd:cd17362 102 YGVGIG 107
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
9-184 |
5.81e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.84 E-value: 5.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 9 RKRTVLKDENLYMVFAVTLLSVLGVASVtpAFPQI-AEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVP 87
Cdd:cd17370 192 KTSLKKLPKAFWLYLLAVALFALGNFSF--AFLILrAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLIL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 88 CLLLFGVSGGLCALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLL-SM 166
Cdd:cd17370 270 GYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLwDL 349
|
170
....*....|....*...
gi 355396663 167 FGWRYPFLlpFAAIPVAL 184
Cdd:cd17370 350 ISPSAAFL--FSAVLALI 365
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
71-345 |
6.89e-05 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 44.67 E-value: 6.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 71 LLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNE--------LLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEA 142
Cdd:cd17368 59 VLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYATigiaapllVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFY 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 143 MGYNSSVLGIGTATYPAIGGLLSM---------FGWRYPFLLPFAAIPVALWITLRLKQNRTATNHKAGNPFKEMLKAFS 213
Cdd:cd17368 139 TSWQSASQQVAIVAGALVGYLLSLtltaealaeWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPTRRELFALLA 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 214 NP-----LAILLFSTSTVTFIILYGAFLTFLPFHLNTSfQATALQIGLISAFMSFTSAVVAfnmkgisKALSERY-RLFL 287
Cdd:cd17368 219 NNrriilLGMLLVAGSTVTFYFTTVYTPTYAKTVLGLS-ARDSFLVTLLAGVANFIWAPLG-------GALSDRIgRRPV 290
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 355396663 288 AFILYCLALIIA-------LNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEENRAAFISL 345
Cdd:cd17368 291 LLVITLAALVTLypvfawlTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSL 355
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
38-257 |
8.52e-05 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 44.52 E-value: 8.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 38 PAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVP-------CLLLFG----VSGGLCALSRSFn 106
Cdd:cd17385 20 PFFPREAEKKGVSDTIIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAgmfvsggCTILFGfldrVPDGTVFIALCF- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 107 ellMMRVLQGIGASALNSLNITIIGDLYKEKYRTeAMGYNSSVLGIGTATYPAIGGLL-SMFGWRYPFL----LPFAAIP 181
Cdd:cd17385 99 ---LVRIVEAVGFAAFITASFAIIAKEFPNNIAT-VLGTLETFSGLGLMLGPPLGGFLyQAGGYELPFLvlgcLLLLTVP 174
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 355396663 182 VALWITLRLKQNRTATNhkagnpfKEMLKAFSNPlAILLFSTSTVTFIILYGAFLTFLPFHLNtSFQATALQIGLI 257
Cdd:cd17385 175 LNMFILPRYDDDPSPKS-------GSMLKLLKIP-SVLLLCLSIVSGSVSLGFLDPTLSPHLR-QFKLSPGQVGLM 241
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
246-397 |
8.53e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.46 E-value: 8.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 246 SFQATALQIGLISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGLNMPT 325
Cdd:cd17324 28 DFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAI 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 355396663 326 LMTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYFALKPTQR 397
Cdd:cd17324 108 AAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPP 179
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
72-190 |
8.55e-05 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 44.33 E-value: 8.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 72 LGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGASALNSLNITIIGDLY-KEKYRTEAMGYNSSVL 150
Cdd:PRK14995 61 MGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFtEEKQRNMALGVWAAVG 140
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 355396663 151 GIGTATYPAIGG-LLSMFGWRYPFLLPFAAIPVALWITLRL 190
Cdd:PRK14995 141 SGGAAFGPLVGGiLLEHFYWGSVFLINVPIVLVVMGLTARY 181
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
216-397 |
1.66e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 43.32 E-value: 1.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 216 LAILLFSTSTVTFIILYGAFLTFLpfhlNTSFQATALQIGLISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLA 295
Cdd:COG2807 21 LAIVLVALNLRPAITSVGPLLPEI----RADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 296 LIIALNLPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPEeNRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFS 375
Cdd:COG2807 97 LLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALA 175
|
170 180
....*....|....*....|..
gi 355396663 376 SGAILAAVMASVLYFALKPTQR 397
Cdd:COG2807 176 VWALLALLALLLWLPLLRRRPA 197
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
56-184 |
1.72e-04 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 43.37 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 56 LVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSR---SFNELLMMRVLQGIGAS-ALNSLNItIIG 131
Cdd:cd17432 54 LTVSIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLSKiakSFEMIIVGRFLVGINAGiSLNVVPM-YLG 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 355396663 132 DLYKEKYRteamgynsSVLGIGTATYPAIG-------GLLSMFG--WRYPFLLPFAAIPVAL 184
Cdd:cd17432 133 ESAPKNLR--------GAVGLVPAIFITLGillgqvlGLRELLGneEGWPLLLALTGVPALL 186
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
58-228 |
1.89e-04 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 43.28 E-value: 1.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 58 VSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEK 137
Cdd:PRK15403 57 VSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQT 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 138 YRTEAMGYNSSVLGIGTATYPAIG-GLLSMFGWRYPFLLpFAAIPVALWITLRLKQNRTATNH----KAGNPFKEMLKAF 212
Cdd:PRK15403 137 KGIKLMAIITSIVLVAPIIGPLSGaALMHFVHWKVLFAI-IAVMGLIAFVGLLLAMPETVKRGavpfSAKSVLRDFRNVF 215
|
170
....*....|....*.
gi 355396663 213 SNPlaILLFSTSTVTF 228
Cdd:PRK15403 216 RNR--LFLTGAATLSL 229
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
37-387 |
1.98e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 43.06 E-value: 1.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 37 TPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQG 116
Cdd:cd06180 19 TPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 117 IGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAI------GGLLSMFGWRYPFLLpFAAIPVALWITLRL 190
Cdd:cd06180 99 AASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLvpaglgGGLSWRAGWLALALL-SAVLLLLSFLLLRR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 191 KQNRTATNHKAGNPFKEMLKAFSNPLAILLFStstVTFIIlygaFLTFLPFHLNTSFqATALQIGLISAFMSFTSAVVAF 270
Cdd:cd06180 178 GPSAPTEASAAESAPGLNRPLWRLALAYGLFG---FGYII----TATFLPLIARETG-AGSLLAGLLWSLFGLAAVPSCF 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 271 NMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQgLNMPTLMTMITNIAPEENRAAFISLNSMSL 350
Cdd:cd06180 250 LWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTF-MAITALVMALARELAPPAAPRALALMTASF 328
|
330 340 350
....*....|....*....|....*....|....*..
gi 355396663 351 RLGQTLGPFLMGGIYSLFGirsVFSSGAILAAVMASV 387
Cdd:cd06180 329 GVGQILGPLLAGWLADATG---GFAPALILAAAALVV 362
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
72-139 |
2.26e-04 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 42.72 E-value: 2.26e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 355396663 72 LGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYR 139
Cdd:cd17379 53 IGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYR 120
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
242-393 |
6.96e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.40 E-value: 6.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 242 HLNTSFQATALQIGLISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQGL 321
Cdd:cd17319 28 TIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAG 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 355396663 322 NMPTLMTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYFALK 393
Cdd:cd17319 108 FFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR 179
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
229-393 |
7.29e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 41.49 E-value: 7.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 229 IILYGAFLTFLPFHLN------------TSFQATALQIGLISAFMSFTSAVVAFnmkgISKALSERY---RLFLAFILYC 293
Cdd:cd17312 3 RIFLGVFLGYAAYYVCrknfsvakppivEEIGLSKDDLGIIGSAFLIAYAVGKF----ISGFLSDRSnirRFMSAGLLLS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 294 LALIIALNLPNCLSALIPA-GLIGAAQGLNMPTLMTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRS 372
Cdd:cd17312 79 ALANIFMGFSTSLWFFAVLwGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRA 158
|
170 180
....*....|....*....|.
gi 355396663 373 VFSSGAILAAVMASVLYFALK 393
Cdd:cd17312 159 AFLVPGIVGLVVAIILFFFLR 179
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
55-393 |
8.63e-04 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 41.04 E-value: 8.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 55 GLVVSSFTIPGLVATPLLGLLADRYG-RKKVLVPCLLLFGVSGGLCALSRSFNE-----LLMMRVLQGIGASALNSLNiT 128
Cdd:cd17326 39 GWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVGNILYALAEYFPSnrkyvMLVARFLIGVGAGNVAVLR-A 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 129 IIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSmfgwrypfllPFAAIPVALWITLRLKQNRTATnhkagnpfkeM 208
Cdd:cd17326 118 YVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFT----------PIGYPGYVIGIKLRFNMYTAPA----------W 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 209 LKAFSNPLAILLFSTSTVTFIILYGAFLTFLPFHLNTS---------FQATALQIGLISAFMSFTSAVVAFNMKGISKAL 279
Cdd:cd17326 178 LMAILGIINIILILFFFKEVVCIFLFFVVLFIFANLETigtpltmdmYGWTREEAVLYNGIILAVSGVLSVLVFLLFKFL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 280 S-----ERYRLFLAFILYCLALIIALNLPNCLSALIpagligaaqGLNMPTLMTMI----TNIAPEENRAAFISLNSMSL 350
Cdd:cd17326 258 SlglidERKILLGGLILFFLGFVVTLPWGITGVILF---------GLGYPIGNVMLytlySKILGPKPQGTMQGVLTASG 328
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 355396663 351 RLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYFALK 393
Cdd:cd17326 329 SLARTLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVFYK 371
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
66-129 |
9.03e-04 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 40.86 E-value: 9.03e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 355396663 66 LVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGASA--LNSLNITI 129
Cdd:cd17446 47 LVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGivLNSVSLNV 112
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
23-118 |
9.61e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 41.02 E-value: 9.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 23 FAVTLLSVLGVASV-------TPAFPQIAE----FFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLL 91
Cdd:cd17358 1 LLATFVANLGSFSFgiavgwsSPALPSLMSdnslSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIP 80
|
90 100
....*....|....*....|....*..
gi 355396663 92 FGVSGGLCALSRSFNELLMMRVLQGIG 118
Cdd:cd17358 81 CILGWLLIAFAKDVWMLYLGRFLAGFG 107
|
|
| MFS_MFSD5_like |
cd17487 |
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily ... |
66-124 |
1.08e-03 |
|
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily domain containing 5 protein (MFSD5) is also called molybdate-anion transporter, or molybdate transporter 2 homolog (MOT2). It acts as an atypical solute carrier (SLC) that mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. It may also play a role in maintaining the glucose homeostasis and pancreatic beta-cell proliferation, as well as in altered energy homeostasis. MFSD5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341040 Cd Length: 385 Bit Score: 40.66 E-value: 1.08e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 355396663 66 LVATPLLGLLADRYGRKKVlvpClLLFGVSGGLCAL---SRSFNELLMMRVLQGIGASALNS 124
Cdd:cd17487 52 VVFGTFVGSLADKFGRKRA---C-LLFCVLYSLSCLtkhSPNFGVLLLGRVLGGISTSLLFS 109
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
48-374 |
1.13e-03 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 40.69 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 48 GISPAKTGLVVSSFTIPGLVATPLLGLLADRYG-RKKVLVPCLLLFGV--SGGLCA-LSRSFNELLMMRVLQGIGASA-- 121
Cdd:pfam12832 30 GLNPSEIGLITAILPLTRILAPPIWGWLADRTGkRKAVVRLASILAAVlfLSVLFIpISLTFWWLALLVVLFSFFWNAil 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 122 --LNSLNITIIGDLYKEKYRTEAMGynssvlGIGTATYPAIGGLlsMFGWRYPFLLPFAAIPV--ALWI-TLRLKQNRTA 196
Cdd:pfam12832 110 pqFEVATLQHLGEKRKDYGRQRLWG------SVGFALSVFGLGA--LFDHYSVGLLPSVLFYLfaALMLlSLLLPLAPPE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 197 TN-HKAGNPFKEMLKAFSNPLAILLFstsTVTFI--ILYGAFLTFLPFHLNtSFQATALQIGLISAFMSFTSAVVAFNMK 273
Cdd:pfam12832 182 MEyESKGGSKAVFWNLLKQPEVIIFF---LAAFLlgFSHGPFYTFLFLYLE-NLGASNTLLGALWALGVVAEIPLFFYAH 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 274 GISKALSERYRLFLAFILYCLALIIALNLPNCLSALIPAGLIGAAQ-GLNMPTLMTMITNIAPEENRAAFISL-NSMSLR 351
Cdd:pfam12832 258 RLLRRFGHRNLLIIALLLTALRWLLYAFFVENPWLVLPIQFLHAISfGLTHAAAIEYVRRIFPGSLQGTGQALySGLYFG 337
|
330 340
....*....|....*....|...
gi 355396663 352 LGQTLGPFLMGGIYSLFGIRSVF 374
Cdd:pfam12832 338 LGGALGSLIGGQLWDLFGARFTF 360
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
231-397 |
1.53e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.23 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 231 LYGAFLTFLPFHLNTSFQATALQIGLISAFMSFTSAVVAFNMKGISKALSERYRLFLAFILYCLALIIALNLPNCLSALI 310
Cdd:cd17478 10 FYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 311 PAGLIGAAQGLNMPTLMTMITNIAPEeNRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYF 390
Cdd:cd17478 90 LVALAGIGSAAFHPEGARLASQAAGG-RRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLR 168
|
....*..
gi 355396663 391 ALKPTQR 397
Cdd:cd17478 169 LRPLKKP 175
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
41-175 |
1.74e-03 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 40.08 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 41 PQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIGAS 120
Cdd:PRK10091 27 TELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGRLVSGFPHG 106
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 355396663 121 ALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLS-MFGWRYPFLL 175
Cdd:PRK10091 107 AFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSqEFSWRYTFLL 162
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
29-125 |
2.39e-03 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 39.93 E-value: 2.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 29 SVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLF--GVSGGLCALsRSFN 106
Cdd:cd17356 22 GILNMKSFQKYFADNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYiiGAIIQVAAI-GKWY 100
|
90
....*....|....*....
gi 355396663 107 ELLMMRVLQGIGASALNSL 125
Cdd:cd17356 101 QLIVGRIIAGLGVGFASVL 119
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
19-188 |
2.86e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 39.52 E-value: 2.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 19 LYMVFAVTLLSVLGVASVTPAFPQiaEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLvpcLLLFGVSGGL 98
Cdd:cd17353 218 LWLMFFLNATAGLMLIGQAKPIGQ--EFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTL---SIAFLIQGVA 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 99 CALSRSFNELLMMRVLqGIGASALN-----SLNITIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGG-LLSMFGWRYP 172
Cdd:cd17353 293 MFLLPFIGSVAVLFVL-GVALIGFCygggfALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAyVLYTGGYNAA 371
|
170
....*....|....*.
gi 355396663 173 FLLPFAAIPVALWITL 188
Cdd:cd17353 372 FIIAAALSLVALALAL 387
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
39-191 |
2.90e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 39.67 E-value: 2.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 39 AFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQGIG 118
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIF 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 355396663 119 ASALNSLNITIIGDLYKEKYRTEAMG-YNSS-VLGIGTATYPAIGGLLSMFGWRYPFLLP-FAAIPVALWITLRLK 191
Cdd:TIGR00881 97 QGMGWPPCGRTVTKWFSRSERGTWVSfWNCShNVGGGLLPPLVLFGIAELYSWHWVFIVPgIIAIIVSLICFLLLR 172
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
16-195 |
2.92e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 39.96 E-value: 2.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 16 DENLYMVFAVTLLSVLGVasvtpafpqiaeffgispaktglvvssftIPGLVATpllGLLADRYGRKKVLVPCLLLFGVS 95
Cdd:TIGR01299 591 DEGAYMIYFVNFLGTLAV-----------------------------LPGNIVS---ALLMDKIGRLRMLAGSMVLSCIS 638
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 96 GGLCALSRSFNELLMMRVL-QGIGASALNSLNITIIgDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSMFGWRYPFL 174
Cdd:TIGR01299 639 CFFLSFGNSESAMIALLCLfGGLSIAAWNALDVLTV-ELYPSDKRATAFGFLNALCKAAAVLGILIFGSFVGITKAAPIL 717
|
170 180
....*....|....*....|.
gi 355396663 175 LPFAAIPVALWITLRLKQNRT 195
Cdd:TIGR01299 718 FASAALACGGLLALKLPDTRG 738
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
26-171 |
3.09e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 39.43 E-value: 3.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 26 TLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIP---------GLVATPLLGLLADRYGRKKVLVPCLLLFGVSG 96
Cdd:cd17369 229 ALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLlavliasvvAAITIPLFGWLSDRVGRRPVYLAGALLAALFA 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 97 ----GLCALSRSFNELLMMRVLQGIGASALNSLNITIIGDLYKEKYRTEAM--GYN-SSVLGIGTATYPAIGGLLSMFGW 169
Cdd:cd17369 309 fpffWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGAslGYQlGAILGGGFAPLIATALVAATGSW 388
|
..
gi 355396663 170 RY 171
Cdd:cd17369 389 WP 390
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
287-392 |
3.16e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 39.26 E-value: 3.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 287 LAFILYCLALIIALNLPNCLSALIPAGL-IGAAqglnMPTLMTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIY 365
Cdd:TIGR00895 90 LLFSVFTLLCALATNVTQLLILRFLAGLgLGGL----MPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLI 165
|
90 100
....*....|....*....|....*..
gi 355396663 366 SLFGIRSVFSSGAILAAVMASVLYFAL 392
Cdd:TIGR00895 166 PVFGWRSLFYVGGIAPLLLLLLLMRFL 192
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
19-391 |
3.46e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 39.32 E-value: 3.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 19 LYMVFAVTLLSVLGVASVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVpcLLLFGVSGGL 98
Cdd:cd17314 5 LYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMA--LAGIMVLAGY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 99 CALSRSFNELLMM---RVLQGIGASALNSLNITIIGDLYKEKyRTEAMGYNSSVLGIGTATY-PAIGGLLSMFGWRYPF- 173
Cdd:cd17314 83 TYLSYVFNSFPLSyacFVFIGAGTGILYGSAVLVTTQYFPDT-KGLALGLPTTGYSLGLVLGsPLLRILWVFYGLALVYt 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 174 ---LLPFAAIPVALWITLRLKQNRTATNHKAGNPFKEMLKAFSNP----LAILLFSTSTVTF-IILYGAFLTFLPFHLNT 245
Cdd:cd17314 162 ilgILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKvfwiLFIAIFLVLIGGFlFIANMASLVRSLQLDAP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 246 SFQATALQI-GLISAFMSFTSAVVAFNMKGISKALSERYrlFLAFILYCLALIIALNLPNCLSALIpaGLIGAAQGLNMP 324
Cdd:cd17314 242 SFVTKLMSIyGLFNAFGRLLWGIVADFFGGRLSTLSILL--TILGLGLCAFLFLLKMTPVGLVLTG--SLLGFSYGGLFT 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 355396663 325 TLMTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYS-LFGIRSVFSSGAILAAVMASVLYFA 391
Cdd:cd17314 318 VYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDrTPSYISAVYIYAVIVFLASAILLAV 385
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
23-111 |
4.52e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 38.82 E-value: 4.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 23 FAVTLLSVLGVASVTPAFpqIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALS 102
Cdd:TIGR00886 222 YSVTFGSFLGVSSIFAML--FKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLG 299
|
....*....
gi 355396663 103 RSFNELLMM 111
Cdd:TIGR00886 300 LVSDGSLAA 308
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
48-397 |
4.77e-03 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 38.71 E-value: 4.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 48 GISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSR--------SFNELLMMRVLQGIGA 119
Cdd:PRK05122 47 GFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCALSGLLYLLAGllaawpvlSLLLLLLGRLLLGIGE 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 120 S----ALNSLNITIIGDLYKEKyrteAMGYNssvlgiGTATYPAIG-----GLLsMFGWRYPFLLPFAAIPVALwITLRL 190
Cdd:PRK05122 127 SlagtGSILWGIGRVGALHTGR----VISWN------GIATYGALAigaplGVL-LYHWGGLAGLGLLIMLLAL-LGLLL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 191 KQNRTATNHKAGN--PFKEMLKAFSNPLAILLFST----STVTFIILY-------GAFLTFLPFhlNTSFQATALQIG-L 256
Cdd:PRK05122 195 ARPRPAVPPVKGErlPFRRVLGRVWPYGMGLALASigfgTIATFITLYyaargwdGAALALTLF--GVAFVGARLLFGnL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 257 ISAFMSFTSAVVAFNMKGISKALseryrLFLAfilyclaliialnlPNCLSALIPAGLIGAAQGLNMPTLMTMITNIAPE 336
Cdd:PRK05122 273 INRLGGLRVAIVSLLVEILGLLL-----LWLA--------------PSPWMALIGAALTGFGFSLVFPALGVEAVKRVPP 333
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 355396663 337 ENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAV-MASVLYFALKPTQR 397
Cdd:PRK05122 334 QNRGAALGAYSVFLDLSLGITGPLAGLVASWFGYPSIFLAAALAALLgLALTWLLYRRAPRA 395
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
243-379 |
4.95e-03 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 38.96 E-value: 4.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 243 LNTSFQATALQIGLISAFMSFTSAVVAFNMKGISKALSERY-----RLFLAFILYCLALIIALNLPNCLSALIPAGLIGA 317
Cdd:pfam05977 36 LMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKimlagQLLLALVSTLLTLLAGLGLLSPWLLLGLTFLGGI 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 355396663 318 AQGLNMPTLMTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAI 379
Cdd:pfam05977 116 GTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPAFTFALNAL 177
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
50-335 |
5.15e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 38.96 E-value: 5.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 50 SPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLC--ALSRSFNELLMMRVLQGIGASALNSLNI 127
Cdd:TIGR00894 74 SGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIpwAAGGGIALVVFCRVIQGLAQGSVSPATH 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 128 TIIGDLYKEKYRTEAMGYNSSVLGIGTATYPAIGGLLSMFGWRYP-----------------FLLPFAAIPVALWITLRL 190
Cdd:TIGR00894 154 KIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWGGWPmifyvfgivgcawsllwFVFPADDPSIHPCISKFE 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 191 KQ--NRTATNHKAGNPFKEMLKAFSNPLAILLFSTSTVTFIILYGAFLTFLPFHLNTSFQATALQIGLISAF---MSFTS 265
Cdd:TIGR00894 234 KKyiNSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLpylFAWLC 313
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 355396663 266 AVVA------FNMKGI-SKALSERYRLFLAFILYCLALIIALNLP-NCLSALIPAGLIGAAQGLNMPTLMTMITNIAP 335
Cdd:TIGR00894 314 SIFAgyladfLKSSKTlSLTAARKIFNGIGGLGPGIFAYALPYLSaAFYLTIIILTLANAVSSGPLAGVLINSLDLAP 391
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
314-395 |
5.42e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 38.69 E-value: 5.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 314 LIGAAQGLNMPTLMTMITNIAPEENRAAFISLNSMSLRLGQTLGPFLMGGIYSLFGIRSVFSSGAILAAVMASVLYFALK 393
Cdd:cd17380 98 LLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP 177
|
..
gi 355396663 394 PT 395
Cdd:cd17380 178 PV 179
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
35-176 |
8.75e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 38.02 E-value: 8.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 35 SVTPAFPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVL 114
Cdd:cd17312 21 NFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGL 100
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 355396663 115 QGIGASALNSLNITIIGDLYKEKYRTEAMGYNSSVLGIGTA-TYPAIGGLLSMFGWRYPFLLP 176
Cdd:cd17312 101 NGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGIlAPILAASLASYYGWRAAFLVP 163
|
|
| MFS_SLC22A31 |
cd17443 |
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ... |
60-116 |
9.12e-03 |
|
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341001 [Multi-domain] Cd Length: 343 Bit Score: 37.83 E-value: 9.12e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 355396663 60 SFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFNELLMMRVLQG 116
Cdd:cd17443 44 SYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVALSASPPTFLVLRLLQG 100
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
27-188 |
9.15e-03 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 37.87 E-value: 9.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 27 LLSVLGvasvtpafPQIAEFFGISPAKTGLVVSSFTIPGLVATPLLGLLADRYGRKKVLVPCLLLFGVSGGLCALSRSFN 106
Cdd:cd17441 17 ILSILA--------PQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355396663 107 ELLMMRVLQGIGASALNSlNITIIGDLYKEKYRTEAMGYNSSVLGIGTaTYPAIGGLLSM--FGWRYpfLLPFAAIPVAL 184
Cdd:cd17441 89 WILVLRGLVGFGIGGVPQ-SVTLYAEFLPMKSRAKCILLIEVFWALGT-VFEVLLAVFVMptLGWRW--LLILSALPLLI 164
|
....
gi 355396663 185 WITL 188
Cdd:cd17441 165 FAVL 168
|
|
| |
