NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|359499969|gb|AEV52552|]
View 

NADH dehydrogenase subunit 2, partial (mitochondrion) [Thylogale stigmatica]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ND2 super family cl31798
NADH dehydrogenase subunit 2; Provisional
 1-189 9.90e-82

NADH dehydrogenase subunit 2; Provisional


The actual alignment was detected with superfamily member MTH00105:

Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 245.91  E-value: 9.90e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   1 APTALLYQISPTLNMKVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYIIATLTLF 80
Cdd:MTH00105 137 APLSILYQISPSINPNLLLTLAILSILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMF 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  81 LMLNFASVTKIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRI 160
Cdd:MTH00105 217 MLLMLNSSTTTLSLSHTWNKTPLMTSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRL 296

                        170       180
                 ....*....|....*....|....*....
gi 359499969 161 IYASTLTMFPTTNNSKIQWPHPQTKTINI 189
Cdd:MTH00105 297 IYSTSLTMFPSTNNMKMKWQFENTKPMTL 325
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-189 9.90e-82

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 245.91  E-value: 9.90e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   1 APTALLYQISPTLNMKVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYIIATLTLF 80
Cdd:MTH00105 137 APLSILYQISPSINPNLLLTLAILSILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMF 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  81 LMLNFASVTKIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRI 160
Cdd:MTH00105 217 MLLMLNSSTTTLSLSHTWNKTPLMTSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRL 296

                        170       180
                 ....*....|....*....|....*....
gi 359499969 161 IYASTLTMFPTTNNSKIQWPHPQTKTINI 189
Cdd:MTH00105 297 IYSTSLTMFPSTNNMKMKWQFENTKPMTL 325
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 17-163 7.55e-14

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 68.60  E-value: 7.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  17 VLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLA----LLNLLIYIIATLTLFLMLNFAS----- 87
Cdd:COG1007  271 LLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGvsaaLFYLLAYLFMNLGAFAVILLLSrkgge 350

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 359499969  88 VTKIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRIIYA 163
Cdd:COG1007  351 AEEIEDLAGLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLRVVKA 426
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 5-150 5.71e-10

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 56.94  E-value: 5.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969    5 LLYQISPTLNMKVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINP----TLALLNLLIYIIATLTLF 80
Cdd:pfam00361 137 LLYLPSSPFIQQILLILAIISMLLGSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTiygiQAAIFHLLTHGLFSAGLF 216

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 359499969   81 LM-----LNFASVTKIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSA 150
Cdd:pfam00361 217 LCagsviYRRVHTRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVVGS 291
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 16-178 6.45e-08

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 51.49  E-value: 6.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   16 KVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGW----MTIIMLINPTLALLNLLIYIIATL---TLFLMLNFASV 88
Cdd:TIGR01770 270 IFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYiligLLAGTLEGIKAVLFYIFIYALMSLgafGVLSLLRSYKD 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   89 TKIKSLTNL--WNKSAP-MTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRIIYAst 165
Cdd:TIGR01770 350 EWIEYISDFagLFKTNPiLAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVVKV-- 427

                         170
                  ....*....|...
gi 359499969  166 ltMFPTTNNSKIQ 178
Cdd:TIGR01770 428 --MYFDKPERRIP 438
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-189 9.90e-82

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 245.91  E-value: 9.90e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   1 APTALLYQISPTLNMKVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYIIATLTLF 80
Cdd:MTH00105 137 APLSILYQISPSINPNLLLTLAILSILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMF 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  81 LMLNFASVTKIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRI 160
Cdd:MTH00105 217 MLLMLNSSTTTLSLSHTWNKTPLMTSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRL 296

                        170       180
                 ....*....|....*....|....*....
gi 359499969 161 IYASTLTMFPTTNNSKIQWPHPQTKTINI 189
Cdd:MTH00105 297 IYSTSLTMFPSTNNMKMKWQFENTKPMTL 325
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-186 2.12e-62

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 196.56  E-value: 2.12e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   1 APTALLYQISPTlNMKVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYIIATLTLF 80
Cdd:MTH00135 137 APFALILQIAPT-NPTLLITLGLTSTLVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAF 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  81 LMLNFASVTKIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRI 160
Cdd:MTH00135 216 LTFKLNSSTKINTLATSWTKAPALTALTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRL 295

                        170       180
                 ....*....|....*....|....*.
gi 359499969 161 IYASTLTMFPTTNNSKIQWPHPQTKT 186
Cdd:MTH00135 296 SYAMTLTISPNTLNGTTPWRLPSTQL 321
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-179 1.22e-55

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 179.35  E-value: 1.22e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   1 APTALLYQISPTLNMKVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYIIATLTLF 80
Cdd:MTH00070 137 APMALLIQISHLLNSNLLIIMGLLSTLIGGWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMF 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  81 LMLNFASVTKIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRI 160
Cdd:MTH00070 217 LMLMNLNSTNINKLSSSWSKNPTLTSMMMLTLLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRL 296

                        170
                 ....*....|....*....
gi 359499969 161 IYASTLTMFPTTNNSKIQW 179
Cdd:MTH00070 297 SYAMSLTTSPNTSNSKLYW 315
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-189 2.97e-55

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 178.09  E-value: 2.97e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   1 APTALLYQISPTLNMKVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYIIATLTLF 80
Cdd:MTH00112 137 APLTLLLMTSNSLNPTLLLTLAILSTLIGGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMF 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  81 LMLNFASVTKIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRI 160
Cdd:MTH00112 217 LTLNTTSTKTLKDMMTSWTKSPTLNTTLMLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRL 296

                        170       180
                 ....*....|....*....|....*....
gi 359499969 161 IYASTLTMFPTTNNSKIQWPHPQTKTINI 189
Cdd:MTH00112 297 TYISTITLPPNTTNMMMKWRTKPKKNTLT 325
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-179 3.16e-41

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 142.03  E-value: 3.16e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   1 APTALLYQISPTLNMKVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYIIATLTLF 80
Cdd:MTH00200 137 APFALLIQLAPALNSNILLLLGLLSVLVGGWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVF 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  81 LMLNFASVTKIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRI 160
Cdd:MTH00200 217 LLLNLLNSTKINSLSSSKTKNPILSMLLGLTLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRL 296

                        170
                 ....*....|....*....
gi 359499969 161 IYASTLTMFPTTNNSKIQW 179
Cdd:MTH00200 297 SYLTLLTLSPNQINMMSSW 315
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-171 9.53e-34

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 122.35  E-value: 9.53e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   1 APTALLYQISPTLNMKVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYIIATLTLF 80
Cdd:MTH00041 137 APLILLISISNLLNSNILILCGILSVLVGGWGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIF 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  81 LMLNFASVTKIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRI 160
Cdd:MTH00041 217 LIGNNFSLSTLSHLNKLSQLNPISAFLFILSILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRI 296

                        170
                 ....*....|.
gi 359499969 161 IYASTLTMFPT 171
Cdd:MTH00041 297 SFNTSLTLFPQ 307
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 6-177 2.45e-22

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 91.81  E-value: 2.45e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   6 LYQISPTLNMKVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYIIATLTLFLMLNF 85
Cdd:MTH00160 134 LILLSYLINNNFIIIIIILSAIIGAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNK 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  86 ASVTKIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRIIYAST 165
Cdd:MTH00160 214 FNIFFLNQLFNSNNKSKKIKFLLFLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSL 293

                        170
                 ....*....|..
gi 359499969 166 LTMFPTTNNSKI 177
Cdd:MTH00160 294 MLNYNKNKWNLK 305
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 1-168 1.15e-21

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 89.84  E-value: 1.15e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   1 APTALLYQISPTLNMKVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYIIATLTLF 80
Cdd:MTH00011 133 APLSILFFFTSHNILPMMTSMAAMSALAGGLGGMNQTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLM 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  81 LMLNFASVTKIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRI 160
Cdd:MTH00011 213 LLFAYLNAFSTKFNSKISSMSQTTSMSLFIMLLSLGGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNL 292


                 ....*...
gi 359499969 161 IYASTLTM 168
Cdd:MTH00011 293 IFNFMYLS 300
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 1-169 1.07e-20

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 87.25  E-value: 1.07e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   1 APTALLYQISPTLNM-KVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYIIATLTL 79
Cdd:MTH00144 129 APLFLLSNFLDLYWLaYLLCVISVLSALVGSIGGLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFL 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  80 FLMLNFASVTKIKSLTNLwNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMR 159
Cdd:MTH00144 209 FFSLWSGDSGSMKDLGSL-KPSYKTGLSIISLLLSLGGLPPFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLS 287

                        170
                 ....*....|
gi 359499969 160 IIYASTLTMF 169
Cdd:MTH00144 288 VFFSSFLSSS 297
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 14-164 7.04e-17

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 76.63  E-value: 7.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  14 NMKVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYIIATLTLFLMLNFASVTKIKS 93
Cdd:MTH00197 135 SFMGLLICSVLSSLIGGIGGMNQSNIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQ 214

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 359499969  94 LTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRIIYAS 164
Cdd:MTH00197 215 QYSNPESMSSNLVFLGLSFLSLGGLPPLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKS 285
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 17-163 7.55e-14

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 68.60  E-value: 7.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  17 VLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLA----LLNLLIYIIATLTLFLMLNFAS----- 87
Cdd:COG1007  271 LLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGvsaaLFYLLAYLFMNLGAFAVILLLSrkgge 350

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 359499969  88 VTKIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRIIYA 163
Cdd:COG1007  351 AEEIEDLAGLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLRVVKA 426
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
17-161 4.53e-12

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 63.69  E-value: 4.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  17 VLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLA----LLNLLIYIIATLTLFLMLNFAS----- 87
Cdd:PRK05777 272 VLAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLVGLAAGTAEGysavLFYLLAYLFMTLGAFGVISLLRrkgge 351

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 359499969  88 VTKIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRII 161
Cdd:PRK05777 352 AESISDFAGLSKRSPLLAAVMTIFMLSLAGIPPTAGFWGKFYVFEAAVEAGLWWLAVIGVLNSAIGAFYYLRVI 425
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 4-162 6.00e-11

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 60.42  E-value: 6.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   4 ALLYQISPTLNmkVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINP----TLALLNLLIYIIATLTL 79
Cdd:MTH00199 238 SILVQIGPVTN--VVLICAVLSIIYGAIGALNQTKIKRLLAYSGIGHMGFILFGVAIGSfesiQASLIYMIIYVIMSICS 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  80 FLMLNFASVTK--IKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFY 157
Cdd:MTH00199 316 FSIILSLKLTKglIVEVSGLSRKNPVIALTLALTFLSIAGIPPLAGFLSKWLILLSGVSSGYYLICIIAVLSSVIAGVYY 395


                 ....*
gi 359499969 158 MRIIY 162
Cdd:MTH00199 396 VRVVQ 400
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 5-150 5.71e-10

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 56.94  E-value: 5.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969    5 LLYQISPTLNMKVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINP----TLALLNLLIYIIATLTLF 80
Cdd:pfam00361 137 LLYLPSSPFIQQILLILAIISMLLGSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTiygiQAAIFHLLTHGLFSAGLF 216

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 359499969   81 LM-----LNFASVTKIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSA 150
Cdd:pfam00361 217 LCagsviYRRVHTRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVVGS 291
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 17-162 1.83e-09

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 55.92  E-value: 1.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  17 VLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYII----ATLTLFL----MLNFASV 88
Cdd:COG0651  274 LLLVLGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAGALFHLLnhalAKALLFLaagaIERATGT 353

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 359499969  89 TKIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRIIY 162
Cdd:COG0651  354 RDLDKLGGLGKRMPLTAAAFLIGALALAGLPPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSLLTLAYFVRIFG 427
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 4-161 5.39e-09

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 54.27  E-value: 5.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   4 ALLYQISPTLNMkvLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINP----TLALLNLLIYIIATLTL 79
Cdd:MTH00196 143 SILVSIGLNVNI--LLIGGLFSLFVGAIGALNQTKIKRLLAYSGIGHMGFVLWGIEIGSfesiQASLVYLFIYIIMSICV 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  80 FLMLNFASVTK--IKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFY 157
Cdd:MTH00196 221 FSIILALNVYKnlIIEFSGLSRRLPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYY 300


                 ....
gi 359499969 158 MRII 161
Cdd:MTH00196 301 VRIV 304
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 16-178 6.45e-08

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 51.49  E-value: 6.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   16 KVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGW----MTIIMLINPTLALLNLLIYIIATL---TLFLMLNFASV 88
Cdd:TIGR01770 270 IFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYiligLLAGTLEGIKAVLFYIFIYALMSLgafGVLSLLRSYKD 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   89 TKIKSLTNL--WNKSAP-MTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRIIYAst 165
Cdd:TIGR01770 350 EWIEYISDFagLFKTNPiLAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVVKV-- 427

                         170
                  ....*....|...
gi 359499969  166 ltMFPTTNNSKIQ 178
Cdd:TIGR01770 428 --MYFDKPERRIP 438
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 17-163 1.14e-07

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 50.65  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  17 VLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYI----IATLTLFLMLNFASVT--- 89
Cdd:PRK08375 273 LLAVLALLSMLVGSLAALGQDDVKRVLAYSTVSQMGYILLGLALLTPLALAAGLLHLlhhaLMKGALFLAAGAIEVTygt 352

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 359499969  90 -KIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRIIYA 163
Cdd:PRK08375 353 rRLSELSGLGRRMPLTAAAFAVASLSLIGVPPTSGFVSKWYLVVGAVEAGQWLVLAVLLASSLLALLYFLRIWYR 427
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 17-162 1.10e-06

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 47.66  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  17 VLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYI----IATLTLFL----MLNFASV 88
Cdd:PRK12667 297 ILIILGAVSAIIGALMMVVQKDVKRLLAYSTISHMGYIFMGIGIGTQLGLAAALFHIinhaIAKSLLFLasgvFIHAAGT 376

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 359499969  89 TKIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRIIY 162
Cdd:PRK12667 377 RDIDELAGLGRKMPIASFAFLIGALSLVGIPPLNGFFSKLLLFNALLESGFYLPALVLLIASAISLVGYFRAWY 450
PRK12662 PRK12662
putative monovalent cation/H+ antiporter subunit D; Reviewed
 16-161 1.62e-05

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 183662 [Multi-domain]  Cd Length: 492  Bit Score: 44.34  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  16 KVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYII----ATLTLFLMLNFAS---- 87
Cdd:PRK12662 280 NVFMILAALAIVFGSVLAILSKDIKRIFAYSSISHIGYIILAVSLNTYYGLAAAVAYIVnhsiVKSALFMVSGSISyhfg 359

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 359499969  88 VTKIKSLTNLWNKSAPMTTAILLTLLSLGGLPPLTGFMPKWLILQELVSNNNIIMATLMALSALLNLFFYMRII 161
Cdd:PRK12662 360 TTKLEDCLNLWKSMPKITLAFVLLSLSLIGMPPTSGFVAKWYILDAFIKSNAWIGLVVLLVGSGLSVIYVWKIV 433
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 3-83 6.19e-05

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 42.54  E-value: 6.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   3 TALLYQISPTLNMKVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLN----LLIYIIATLT 78
Cdd:MTH00198 344 TVYILLTSLVITSKLLLSVAIISLVVGAFGALNQTRIKRLLAYSGIGHIGFILIGVSAGTYESLQAswtyAVTYLVSALA 423


                 ....*
gi 359499969  79 LFLML 83
Cdd:MTH00198 424 SFTVI 428
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 17-56 1.41e-04

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 41.61  E-value: 1.41e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 359499969  17 VLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTI 56
Cdd:COG1008  277 LLAALGVIGIIYGALVALAQTDLKRLIAYSSVSHMGFVLL 316
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 17-162 1.92e-04

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 41.08  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   17 VLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYIIA----TLTLFLMLNF----ASV 88
Cdd:TIGR01972 271 VLAALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVLLGIFSFNELGISGAVFQMIShgliTAALFLLVGVlyerAHT 350

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 359499969   89 TKIKSLTNLWNKsAPMTTAILLTLLSLGGLPPLT-GFMPKWLILQELVSNN---NIIMATLMALSALLNLFFYMRIIY 162
Cdd:TIGR01972 351 RDIAKYGGLANK-MPVLAAFFMLFAMASLGLPGTsGFVGEFLILLGSFKVNpvvAFLAALGIVLAAAYMLTLYKRVFF 427
NADH_dehy_S2_C pfam06444
NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region ...
 155-188 2.21e-04

NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with pfam00361.


Pssm-ID: 461914 [Multi-domain]  Cd Length: 51  Bit Score: 37.62  E-value: 2.21e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 359499969  155 FFYMRIIYASTLTMFPTTNNSKIQWPHPQTKTIN 188
Cdd:pfam06444   1 FFYLRLSYSTTLTLFPNTNNSKMKWRFNSTKNTL 34
PRK08668 PRK08668
NADH dehydrogenase subunit M; Validated
 7-163 1.72e-03

NADH dehydrogenase subunit M; Validated


Pssm-ID: 236332 [Multi-domain]  Cd Length: 610  Bit Score: 38.44  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969   7 YQISPTLNMkVLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYII--ATLTLFLMLN 84
Cdd:PRK08668 265 YRGVPLFNY-ILAWLGNISIIVGTLMAILQEDIKKLIAYSSVANGGYILVGLGLGTSLGFAGGLFHVFnhALFKGLFFLI 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359499969  85 FASV------TKIKSLTNLWNKsAPMTTAILLTLLSLGGLPPLT-GFMPKWLILQELVSNNNIIMATLMALSALLNLFFY 157
Cdd:PRK08668 344 FAAViyrtgtTKISEMGGLIEK-MPFTFAMYLVAIISLAGIPPMsGFASKWLIFEALISKGMPITAFMAFFGSIGSFLYV 422


                 ....*.
gi 359499969 158 MRIIYA 163
Cdd:PRK08668 423 FRPLAG 428
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 17-56 3.31e-03

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 37.49  E-value: 3.31e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 359499969  17 VLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTI 56
Cdd:PRK05846 279 IIITLGVIAIIYGALVALAQTDIKKLIAYSSISHMGFVTL 318
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
17-77 3.48e-03

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 37.34  E-value: 3.48e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 359499969  17 VLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYIIATL 77
Cdd:PRK02504 278 LFTALAILSMVLGNVVALAQTSMKRMLAYSSIGQAGFVMIGLVAGTEAGYASMVFYLLAYL 338
PRK08676 PRK08676
hydrogenase membrane subunit; Validated
 17-75 7.27e-03

hydrogenase membrane subunit; Validated


Pssm-ID: 181537 [Multi-domain]  Cd Length: 485  Bit Score: 36.27  E-value: 7.27e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 359499969  17 VLITLAFLSTTLGGWGGLNQTHLRKILAYSSIAHMGWMTIIMLINPTLALLNLLIYIIA 75
Cdd:PRK08676 275 VLIGLGIFSIAVAAFSMLSQRNLKKLIAFSSIEHMGLMLLGIGIGTPLALFWMLFHMLA 333
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH