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Conserved domains on  [gi|383292708|gb|AFH06422|]
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lethal (3) L1231, isoform C [Drosophila melanogaster]

Protein Classification

zf-C3Hc3H domain-containing protein( domain architecture ID 10620855)

zf-C3Hc3H domain-containing protein may be a DNA-binding protein and is similar to human KAT8 regulatory NSL complex subunit 2 that, as part of the NSL complex, is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-C3Hc3H pfam13891
Potential DNA-binding domain; This domain is likely to be the DNA-binding domain of chromatin ...
 712-767 9.79e-16

Potential DNA-binding domain; This domain is likely to be the DNA-binding domain of chromatin re-modelling proteins and helicases.


:

Pssm-ID: 464023  Cd Length: 62  Bit Score: 72.38  E-value: 9.79e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 383292708   712 CKQPTLSMAAHCERHIVNNSTQQLFQPCVAWRMDGTACQAPVFDVLHTLALCKVHS 767
Cdd:pfam13891    7 CKQKALPGTKYCYRHILEDPNQALFKQCSYVFSGNKRCGNPVLKSDVPSPLCPEHA 62
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 245-578 3.08e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 3.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383292708  245 SPPTSPASLPSPTLPPATAAVTAMVAPISVSPKGGLPLPPSKFHHTTLAQHLQKVECLKKKKSLPLACQNNNNNSNLPNN 324
Cdd:PHA03247 2607 DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRR 2686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383292708  325 nnveSLKKPVVQGTSYNQTHPPPlmvfNTGTVAVPAQSPQTAAPQKhstgnsvddsdlneipvnvifrkPQEAGGAaktg 404
Cdd:PHA03247 2687 ----AARPTVGSLTSLADPPPPP----PTPEPAPHALVSATPLPPG-----------------------PAAARQA---- 2731

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383292708  405 gpgglSAPVSGTPQTRPAEVKMVTPLTPPTPPEMSAPPLLAQMQPPQIPTSCVPALAPSFKVSSPAVLSPKVISPAPASP 484
Cdd:PHA03247 2732 -----SPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPAD 2806

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383292708  485 KLLCPTAPASTNSLQIAPKAVPATTTSSAPALATK-------SEQMSSKVANLNAFNRQAPIASKGVRNGITNNNNNRNS 557
Cdd:PHA03247 2807 PPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPppgppppSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRL 2886

                         330       340
                  ....*....|....*....|.
gi 383292708  558 NVVAKKSSPTSMPPPKDPIAP 578
Cdd:PHA03247 2887 ARPAVSRSTESFALPPDQPER 2907
 
Name Accession Description Interval E-value
zf-C3Hc3H pfam13891
Potential DNA-binding domain; This domain is likely to be the DNA-binding domain of chromatin ...
 712-767 9.79e-16

Potential DNA-binding domain; This domain is likely to be the DNA-binding domain of chromatin re-modelling proteins and helicases.


Pssm-ID: 464023  Cd Length: 62  Bit Score: 72.38  E-value: 9.79e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 383292708   712 CKQPTLSMAAHCERHIVNNSTQQLFQPCVAWRMDGTACQAPVFDVLHTLALCKVHS 767
Cdd:pfam13891    7 CKQKALPGTKYCYRHILEDPNQALFKQCSYVFSGNKRCGNPVLKSDVPSPLCPEHA 62
PHA03247 PHA03247
large tegument protein UL36; Provisional
 245-578 3.08e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 3.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383292708  245 SPPTSPASLPSPTLPPATAAVTAMVAPISVSPKGGLPLPPSKFHHTTLAQHLQKVECLKKKKSLPLACQNNNNNSNLPNN 324
Cdd:PHA03247 2607 DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRR 2686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383292708  325 nnveSLKKPVVQGTSYNQTHPPPlmvfNTGTVAVPAQSPQTAAPQKhstgnsvddsdlneipvnvifrkPQEAGGAaktg 404
Cdd:PHA03247 2687 ----AARPTVGSLTSLADPPPPP----PTPEPAPHALVSATPLPPG-----------------------PAAARQA---- 2731

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383292708  405 gpgglSAPVSGTPQTRPAEVKMVTPLTPPTPPEMSAPPLLAQMQPPQIPTSCVPALAPSFKVSSPAVLSPKVISPAPASP 484
Cdd:PHA03247 2732 -----SPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPAD 2806

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383292708  485 KLLCPTAPASTNSLQIAPKAVPATTTSSAPALATK-------SEQMSSKVANLNAFNRQAPIASKGVRNGITNNNNNRNS 557
Cdd:PHA03247 2807 PPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPppgppppSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRL 2886

                         330       340
                  ....*....|....*....|.
gi 383292708  558 NVVAKKSSPTSMPPPKDPIAP 578
Cdd:PHA03247 2887 ARPAVSRSTESFALPPDQPER 2907
 
Name Accession Description Interval E-value
zf-C3Hc3H pfam13891
Potential DNA-binding domain; This domain is likely to be the DNA-binding domain of chromatin ...
 712-767 9.79e-16

Potential DNA-binding domain; This domain is likely to be the DNA-binding domain of chromatin re-modelling proteins and helicases.


Pssm-ID: 464023  Cd Length: 62  Bit Score: 72.38  E-value: 9.79e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 383292708   712 CKQPTLSMAAHCERHIVNNSTQQLFQPCVAWRMDGTACQAPVFDVLHTLALCKVHS 767
Cdd:pfam13891    7 CKQKALPGTKYCYRHILEDPNQALFKQCSYVFSGNKRCGNPVLKSDVPSPLCPEHA 62
PHA03247 PHA03247
large tegument protein UL36; Provisional
 245-578 3.08e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 3.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383292708  245 SPPTSPASLPSPTLPPATAAVTAMVAPISVSPKGGLPLPPSKFHHTTLAQHLQKVECLKKKKSLPLACQNNNNNSNLPNN 324
Cdd:PHA03247 2607 DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRR 2686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383292708  325 nnveSLKKPVVQGTSYNQTHPPPlmvfNTGTVAVPAQSPQTAAPQKhstgnsvddsdlneipvnvifrkPQEAGGAaktg 404
Cdd:PHA03247 2687 ----AARPTVGSLTSLADPPPPP----PTPEPAPHALVSATPLPPG-----------------------PAAARQA---- 2731

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383292708  405 gpgglSAPVSGTPQTRPAEVKMVTPLTPPTPPEMSAPPLLAQMQPPQIPTSCVPALAPSFKVSSPAVLSPKVISPAPASP 484
Cdd:PHA03247 2732 -----SPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPAD 2806

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383292708  485 KLLCPTAPASTNSLQIAPKAVPATTTSSAPALATK-------SEQMSSKVANLNAFNRQAPIASKGVRNGITNNNNNRNS 557
Cdd:PHA03247 2807 PPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPppgppppSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRL 2886

                         330       340
                  ....*....|....*....|.
gi 383292708  558 NVVAKKSSPTSMPPPKDPIAP 578
Cdd:PHA03247 2887 ARPAVSRSTESFALPPDQPER 2907
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 439-585 2.94e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 41.77  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383292708  439 SAPPLLAQMQPPQIPTSCVPALAPSFKVSSPAVLSPkvISPAPASPKLLCPTAPASTNSLQIAPKAVPATTTSSAPALAT 518
Cdd:PRK07994  370 VPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPAS--APQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSEPAAAS 447

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 383292708  519 KSEQMSSKVANLNAFnRQAPIASKGVRNGITNNNNNRNSNVVAKKSSPTSMPPPKDPIAPIAANELT 585
Cdd:PRK07994  448 RARPVNSALERLASV-RPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALEHEKTPELA 513
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
391-581 8.63e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 8.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383292708  391 FRKPQEAGGAAKtggPGGLSAPVSGTPQTRPAEVKMVTPLTPPTPPEMSAPPLLAQMQPP-QIPTSCVPALAP------- 462
Cdd:PRK12323  363 FRPGQSGGGAGP---ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVaAAPARRSPAPEAlaaarqa 439

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383292708  463 --SFKVSSPAVLSPKVISPAPASPKLLCPTAPASTNSLQIAPKAVPATTTSSAPALATKSEQMSSKVANLNAFNRQAPIA 540
Cdd:PRK12323  440 saRGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPA 519

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 383292708  541 SKGVRNGITNNNNNRNSNVVAKKSSPT--SMPPPKDPIAPIAA 581
Cdd:PRK12323  520 GWVAESIPDPATADPDDAFETLAPAPAaaPAPRAAAATEPVVA 562
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 393-521 9.97e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.08  E-value: 9.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383292708  393 KPQEAGGAAKTGGPGGLSAPVSGTPQTRPAEVKMVTPLTPPTPPEMSAPPLLAQMQPPQIPTSCVPALAP-SFKVSSPAV 471
Cdd:PRK14951  365 KPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPaAAPAAAPAA 444

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 383292708  472 LSPKVISPAPASPKLLCPtaPASTNSLQIAPKAVPATTTSSAPALATKSE 521
Cdd:PRK14951  445 VALAPAPPAQAAPETVAI--PVRVAPEPAVASAAPAPAAAPAAARLTPTE 492
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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