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Conserved domains on  [gi|386788575|gb|AFJ34694|]
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TetR family transcriptional regulator [Mycobacterium sp. MOTT36Y]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
1-147 2.04e-14

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 68.00  E-value: 2.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386788575   1 MLSVKGFAGTRLTDVADDAEIQAPAIYYYFPSREDLIEEVmycgIHDMRTHLQKTLDALPAGMAPMDRIMVAVEAHLRHA 80
Cdd:COG1309   18 LFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAV----LERLLEELLAALEEALAAEDPRERLRALLRAYLEFL 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 386788575  81 LELSDYTTASIRNSGQIPsrlskRQKKEEAAYGRIWQGLFADAVAEGEVNPELDPQLARFLVMGAMN 147
Cdd:COG1309   94 AENPALARLLLAEAAELP-----ELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLALLD 155
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
1-147 2.04e-14

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 68.00  E-value: 2.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386788575   1 MLSVKGFAGTRLTDVADDAEIQAPAIYYYFPSREDLIEEVmycgIHDMRTHLQKTLDALPAGMAPMDRIMVAVEAHLRHA 80
Cdd:COG1309   18 LFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAV----LERLLEELLAALEEALAAEDPRERLRALLRAYLEFL 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 386788575  81 LELSDYTTASIRNSGQIPsrlskRQKKEEAAYGRIWQGLFADAVAEGEVNPELDPQLARFLVMGAMN 147
Cdd:COG1309   94 AENPALARLLLAEAAELP-----ELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLALLD 155
TetR_C_24 pfam17932
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 65-175 1.26e-11

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.


Pssm-ID: 465574  Cd Length: 114  Bit Score: 59.11  E-value: 1.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386788575   65 PMDRIMVAVEAHLRHALELSDYTTASIRNSGQIPSRLSKRQKKEEAAYGRIWQGLFADAVAEGEVNPeLDPQLARFLVMG 144
Cdd:pfam17932   4 PVERLRALVRAHVRVHAERRDEAAVFLRELRSLSPEHRAEIRALRREYERLLRDLIEEGVAAGEFRD-LDPKLAALAILG 82

                          90       100       110
                  ....*....|....*....|....*....|..
gi 386788575  145 AMNWTAEWWDPR-RGSVDAIVANAQLLVRSGL 175
Cdd:pfam17932  83 MLNWVYRWYRPDgPLSPEEIADQYADLLLRGL 114
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
6-142 3.60e-06

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 45.66  E-value: 3.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386788575   6 GFAGTRLTDVADDAEIQAPAIYYYFPSREDLIEEVMYCGIHDMRTHLqktLDALPAGMAPMDRImVAVEAHLRHALELSD 85
Cdd:NF041196  23 GYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLREAV---EPQRAGGGSKLQEL-VDLTHVLARRLRTDP 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386788575  86 YTTASIRNSGQIPSRLSKRqkkeEAAYGRiW----QGLFADAVAEGEVNPELDP-QLARFLV 142
Cdd:NF041196  99 VVRAGVRLSIEQAAIGAGL----PTPYRE-WidlvAELLAEARAAGELLPGVDPeEAARLLV 155
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 1-40 7.56e-04

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 39.34  E-value: 7.56e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 386788575   1 MLSVKGFAGTRLTDVADDAEIQAPAIYYYFPSREDLIEEV 40
Cdd:PRK09975  23 QFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEM 62
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
1-147 2.04e-14

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 68.00  E-value: 2.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386788575   1 MLSVKGFAGTRLTDVADDAEIQAPAIYYYFPSREDLIEEVmycgIHDMRTHLQKTLDALPAGMAPMDRIMVAVEAHLRHA 80
Cdd:COG1309   18 LFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAV----LERLLEELLAALEEALAAEDPRERLRALLRAYLEFL 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 386788575  81 LELSDYTTASIRNSGQIPsrlskRQKKEEAAYGRIWQGLFADAVAEGEVNPELDPQLARFLVMGAMN 147
Cdd:COG1309   94 AENPALARLLLAEAAELP-----ELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLALLD 155
TetR_C_24 pfam17932
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 65-175 1.26e-11

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.


Pssm-ID: 465574  Cd Length: 114  Bit Score: 59.11  E-value: 1.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386788575   65 PMDRIMVAVEAHLRHALELSDYTTASIRNSGQIPSRLSKRQKKEEAAYGRIWQGLFADAVAEGEVNPeLDPQLARFLVMG 144
Cdd:pfam17932   4 PVERLRALVRAHVRVHAERRDEAAVFLRELRSLSPEHRAEIRALRREYERLLRDLIEEGVAAGEFRD-LDPKLAALAILG 82

                          90       100       110
                  ....*....|....*....|....*....|..
gi 386788575  145 AMNWTAEWWDPR-RGSVDAIVANAQLLVRSGL 175
Cdd:pfam17932  83 MLNWVYRWYRPDgPLSPEEIADQYADLLLRGL 114
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
6-142 3.60e-06

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 45.66  E-value: 3.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386788575   6 GFAGTRLTDVADDAEIQAPAIYYYFPSREDLIEEVMYCGIHDMRTHLqktLDALPAGMAPMDRImVAVEAHLRHALELSD 85
Cdd:NF041196  23 GYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLREAV---EPQRAGGGSKLQEL-VDLTHVLARRLRTDP 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386788575  86 YTTASIRNSGQIPSRLSKRqkkeEAAYGRiW----QGLFADAVAEGEVNPELDP-QLARFLV 142
Cdd:NF041196  99 VVRAGVRLSIEQAAIGAGL----PTPYRE-WidlvAELLAEARAAGELLPGVDPeEAARLLV 155
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
1-40 6.97e-06

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 42.01  E-value: 6.97e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 386788575    1 MLSVKGFAGTRLTDVADDAEIQAPAIYYYFPSREDLIEEV 40
Cdd:pfam00440   8 LFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 1-40 7.56e-04

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 39.34  E-value: 7.56e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 386788575   1 MLSVKGFAGTRLTDVADDAEIQAPAIYYYFPSREDLIEEV 40
Cdd:PRK09975  23 QFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEM 62
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 6-90 1.03e-03

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 38.76  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386788575   6 GFAGTRLTDVADDAEIQAPAIYYYFPSREDLIEEVMYcGIHDMrthLQKTLDALPAGMAPmdriMVAVEAHLRHALELS- 84
Cdd:PRK15008  35 GFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLR-QILDI---WLAPLKAFREDFAP----LAAIKEYIRLKLEVSr 106


                 ....*.
gi 386788575  85 DYTTAS 90
Cdd:PRK15008 107 DYPQAS 112
TetR_C_4 pfam08359
YsiA-like protein, C-terminal region; The members of this family are thought to be TetR-type ...
 65-153 1.25e-03

YsiA-like protein, C-terminal region; The members of this family are thought to be TetR-type transcriptional regulators that bear particular similarity to YsiA, a hypothetical protein expressed by B. subtilis.


Pssm-ID: 285548  Cd Length: 133  Bit Score: 37.74  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386788575   65 PMDRIMVAVEAHLRhALElSDYTTASIRnsgQIPSRLSK---RQKKEEA--AYGRIWQGLFADAVAEGEVNPELDPQLAR 139
Cdd:pfam08359  22 AEEKLRLLIEMHFS-QLS-ADPHLAIVT---QLELRQSNlelRQKINEVlkGYLTLIDEIIAEGKESGEFREELDVRLAR 96

                          90
                  ....*....|....
gi 386788575  140 FLVMGAMNWTAEWW 153
Cdd:pfam08359  97 QMIFGTLDETVTNW 110
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
6-78 3.80e-03

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 36.84  E-value: 3.80e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386788575   6 GFAGTRLTDVADDAEIQAPAIYYYFPSREDLIEEVMYCGIHDMRTHLQKTLDALPAGMAPMDRIMVAVEAHLR 78
Cdd:COG3226   25 GVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLEDAAEALADLLAELLP 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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