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Conserved domains on  [gi|398656970|gb|AFO90936|]
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transcriptional regulator, MarR family [Phaeobacter inhibens DSM 17395]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-140 1.02e-26

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 97.73  E-value: 1.02e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398656970   1 MSEPPVDTLQFPAHLIRRLHQISVALFADHMArnDIDLTPVQFAAIEAVAHEPGVDQATIAARIAYDRATLGKVIDRLEA 80
Cdd:COG1846    1 MSDEPDPAEERLGLLLRRLARALRRALDRALA--ELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEE 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 398656970  81 KALIRRDISTTDRRARVVTLTDSGQSLLRRALPIVAELQADILTGLSPTEQVQMTTLLTK 140
Cdd:COG1846   79 KGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRR 138
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-140 1.02e-26

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 97.73  E-value: 1.02e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398656970   1 MSEPPVDTLQFPAHLIRRLHQISVALFADHMArnDIDLTPVQFAAIEAVAHEPGVDQATIAARIAYDRATLGKVIDRLEA 80
Cdd:COG1846    1 MSDEPDPAEERLGLLLRRLARALRRALDRALA--ELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEE 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 398656970  81 KALIRRDISTTDRRARVVTLTDSGQSLLRRALPIVAELQADILTGLSPTEQVQMTTLLTK 140
Cdd:COG1846   79 KGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRR 138
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
37-131 4.79e-20

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 79.56  E-value: 4.79e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398656970    37 DLTPVQFAAIEAVAHEPGVDQATIAARIAYDRATLGKVIDRLEAKALIRRDISTTDRRARVVTLTDSGQSLLRRALPIVA 116
Cdd:smart00347   7 GLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARS 86

                           90
                   ....*....|....*
gi 398656970   117 ELQADILTGLSPTEQ 131
Cdd:smart00347  87 ETLAELLAGLTAEEQ 101
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 53-140 9.99e-10

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 53.85  E-value: 9.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398656970  53 PGVDQATIAARIAYDRATLGKVIDRLEAKALIRRDISTTDRRARVVTLTDSGQSLLRRALPIVAELQADILTGLSPTEQV 132
Cdd:PRK03573  45 PEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEIE 124


                 ....*...
gi 398656970 133 QMTTLLTK 140
Cdd:PRK03573 125 QLITLIAK 132
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 36-95 1.16e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 51.44  E-value: 1.16e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 398656970   36 IDLTPVQFAAIEAVAHEPGVDQATIAARIAYDRATLGKVIDRLEAKALIRRDISTTDRRA 95
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-140 1.02e-26

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 97.73  E-value: 1.02e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398656970   1 MSEPPVDTLQFPAHLIRRLHQISVALFADHMArnDIDLTPVQFAAIEAVAHEPGVDQATIAARIAYDRATLGKVIDRLEA 80
Cdd:COG1846    1 MSDEPDPAEERLGLLLRRLARALRRALDRALA--ELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEE 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 398656970  81 KALIRRDISTTDRRARVVTLTDSGQSLLRRALPIVAELQADILTGLSPTEQVQMTTLLTK 140
Cdd:COG1846   79 KGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRR 138
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
37-131 4.79e-20

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 79.56  E-value: 4.79e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398656970    37 DLTPVQFAAIEAVAHEPGVDQATIAARIAYDRATLGKVIDRLEAKALIRRDISTTDRRARVVTLTDSGQSLLRRALPIVA 116
Cdd:smart00347   7 GLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARS 86

                           90
                   ....*....|....*
gi 398656970   117 ELQADILTGLSPTEQ 131
Cdd:smart00347  87 ETLAELLAGLTAEEQ 101
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 53-140 9.99e-10

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 53.85  E-value: 9.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398656970  53 PGVDQATIAARIAYDRATLGKVIDRLEAKALIRRDISTTDRRARVVTLTDSGQSLLRRALPIVAELQADILTGLSPTEQV 132
Cdd:PRK03573  45 PEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEIE 124


                 ....*...
gi 398656970 133 QMTTLLTK 140
Cdd:PRK03573 125 QLITLIAK 132
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 36-95 1.16e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 51.44  E-value: 1.16e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 398656970   36 IDLTPVQFAAIEAVAHEPGVDQATIAARIAYDRATLGKVIDRLEAKALIRRDISTTDRRA 95
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 38-95 2.15e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 45.62  E-value: 2.15e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 398656970   38 LTPVQFAAIEAVAHEPGVDQATIAARIAYDRATLGKVIDRLEAKALIRRDISTTDRRA 95
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRRE 58
HTH_27 pfam13463
Winged helix DNA-binding domain;
38-104 3.98e-05

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 39.58  E-value: 3.98e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398656970   38 LTPVQFAAIEAVAHE-PGVDQATIAARIAYDRATLGKVIDRLEAKALIRRDISTTDRRARVVTLTDSG 104
Cdd:pfam13463   1 LTRLEALILHNIGHRgDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 59-140 5.01e-04

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 38.58  E-value: 5.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398656970  59 TIAARIAydratlgkviDRLEAKALIRRDISTTDRRARVVTLTDSGQSLLRRALPIVAELQADILTGLSPTEQVQMTTLL 138
Cdd:PRK10870  86 TNATRIA----------DELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQIT 155


                 ..
gi 398656970 139 TK 140
Cdd:PRK10870 156 RK 157
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
15-140 5.28e-04

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 38.34  E-value: 5.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398656970  15 LIRRLHQISVALFADHMArnDIDLTPVQFAAIEAVAHEPGVDQATIAARIAYDRATLGKVIDRLEAKALIRRDISTTDRR 94
Cdd:PRK11512  17 LIHMVNQKKDRLLNEYLS--PLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKR 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 398656970  95 ARVVTLTDSGQSLLRRALPIVAE-LQADILTGLSPTEQVQMTTLLTK 140
Cdd:PRK11512  95 GVLVKLTTSGAAICEQCHQLVGQdLHQELTKNLTADEVATLEHLLKK 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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