BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  222 FVDVTLSCEGHSIKAHKMVLSACSPYFQALFYD-NPCQHPIIIMRDVSWSDLKALVEFMYKGEINVCQDQINPLLKVAET 300
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                  ....*
gi 440215109  301 LKIRG 305
Cdd:cd18315    81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  222 FVDVTLSCEGHSIKAHKMVLSACSPYFQALFYD-NPCQHPIIIMRDVSWSDLKALVEFMYKGEINVCQDQINPLLKVAET 300
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                  ....*
gi 440215109  301 LKIRG 305
Cdd:cd18315    81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109    224 DVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPC--QHPIIIMRDVSWSDLKALVEFMYKGEINVCQDQINPLLKVAETL 301
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                    ....*...
gi 440215109    302 KIRGLAEV 309
Cdd:smart00225   81 QIPGLVEL 88

kelch-like protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  223 VDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQHPIIIMRDVswSDLKALVEFMYKGEINVCQDQINPLLKVAETLK 302
Cdd:PHA03098   12 ESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINLNIDY--DSFNEVIKYIYTGKINITSNNVKDILSIANYLI 89

                  .
gi 440215109  303 I 303
Cdd:PHA03098   90 I 90

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  222 FVDVTLSCEGHSIKAHKMVLSACSPYFQALFYD-NPCQHPIIIMRDVSWSDLKALVEFMYKGEINVCQDQINPLLKVAET 300
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                  ....*
gi 440215109  301 LKIRG 305
Cdd:cd18315    81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109    224 DVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPC--QHPIIIMRDVSWSDLKALVEFMYKGEINVCQDQINPLLKVAETL 301
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                    ....*...
gi 440215109    302 KIRGLAEV 309
Cdd:smart00225   81 QIPGLVEL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  218 QSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNP---CQHPIIIMRDVSWSDLKALVEFMYKGEINVCQDQINPL 294
Cdd:cd18293    11 NSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPppaGQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDV 90

                          90       100
                  ....*....|....*....|...
gi 440215109  295 LKVAETLkirGLAEVSAGRGEGG 317
Cdd:cd18293    91 LAAARRL---QISELESLCLEGG 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  211 NVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDN--PCQHPIIIMRDVSWSDLKALVEFMYKGEINVCQ 288
Cdd:cd18238     4 KVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEmaESKQDSITIKDIDEEAVELLVDFAYTGKLTLTV 83

                          90       100
                  ....*....|....*....|...
gi 440215109  289 DQINPLLKVAETLKIRGLAEVSA 311
Cdd:cd18238    84 DNVQSLLYAASLLQVEEVAKACC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  207 SNLTNVFDELLQSESFVDVTLSCEGHSIK----AHKMVLSACSPYFQALFYDNP---CQHPIIIMRDVSWSDLKALVEFM 279
Cdd:cd18211    10 SNLLNEMHKLRLLGHLCDVTVQVEHQGSKeefsAHKAVLAASSKYFKEVFLNEKisdGKNTNVMLNEIYTADFASFLEFV 89

                          90       100       110
                  ....*....|....*....|....*....|
gi 440215109  280 YKGEINVCQDQINPLLKVAETLKIRGLAEV 309
Cdd:cd18211    90 YTAKVEVEEDRVQRMLEIAEKLKCLDLSET 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  212 VFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQHPI--IIMRDVSWSDLKALVEFMYKGEINVCQD 289
Cdd:cd18339    11 VMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAkkIEIKDVDGQTLSKLIDYIYTAEIEVTEE 90

                          90
                  ....*....|....
gi 440215109  290 QINPLLKVAETLKI 303
Cdd:cd18339    91 NVQVLLPAASLLQL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  213 FDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNpCQHPIIIMRDVSWSDLKALVEFMYKGEINV-CQDQI 291
Cdd:cd18221     9 LNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDF-TQEPLVEIEGVSNMAFRHLIEFTYTAKLMVqGEEEA 87

                          90
                  ....*....|..
gi 440215109  292 NPLLKVAETLKI 303
Cdd:cd18221    88 NDVWKAAEYLQM 99

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  213 FDELLQSESFVDVTLSC-EGHSIKAHKMVLSACSPYFQALFydnpCQHPIIIM-RDVSWSDLKALVEFMYKGEINVCQDQ 290
Cdd:cd18299     3 LRNLLHSPSCADVVFILqGGVRIFAHRIVLAAASSVFADLF----LMMTVVTLdSDITPEAFRRVLEFLYTGVLDENEDD 78

                          90
                  ....*....|...
gi 440215109  291 INPLLKVAETLKI 303
Cdd:cd18299    79 LKELKDAAELLEL 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  208 NLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQHPI--IIMRDVSWSDLKALVEFMYKGEIN 285
Cdd:cd18250     7 HLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRAdrVVLHGVSAEILGLLLDFSYTGRVT 86

                          90       100
                  ....*....|....*....|...
gi 440215109  286 VCQDQINPLLKVAETLKIRGLAE 308
Cdd:cd18250    87 VTQDNVEALLRAADLFQFPSVKE 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  213 FDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPC--QHPIIIMRDVSWSDLKALVEFMYKGEINVCqdq 290
Cdd:cd18287    13 IGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMResQQSEIELKDTNAEAFKALLKYIYTGRLTLT--- 89

                          90
                  ....*....|....*..
gi 440215109  291 inpLLKVAETLKIRGLA 307
Cdd:cd18287    90 ---DLKEDVLLDVLGLA 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  212 VFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYD--NPCQHPIIIMRDVSWSDLKALVEFMYKGEINVCQD 289
Cdd:cd18338    11 VMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGemSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEE 90

                          90
                  ....*....|....*
gi 440215109  290 QINPLLKVAETLKIR 304
Cdd:cd18338    91 NVQVLLPAAGLLQLQ 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  224 DVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPC--QHPIIIMRDVSWSDLKALVEFMYKGEINVCQDQINPLLKVAETL 301
Cdd:cd18234     3 DVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVReaTEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACLL 82

                  ....*....
gi 440215109  302 KirgLAEVS 310
Cdd:cd18234    83 Q---LSEVV 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  204 NYQSNLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQ--HPIIIMRDVSWSDLKALVEFMYK 281
Cdd:cd18256     2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSEssKDVVQIHGVEPDIFHILLDFIYT 81

                          90       100
                  ....*....|....*....|....*...
gi 440215109  282 GEINVCQDQINPLLKVAETLKirgLAEV 309
Cdd:cd18256    82 GVVEVTVSNVQELLVAADMLQ---LTEV 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  214 DELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQHPIIImRDVSWSDLKALVEFMYKGEINVCQDQINP 293
Cdd:cd18226    14 DDRQKQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNPNTDAVTL-DHVSYSVFQHLLEFLYTSEFFVYENEIPL 92

                          90
                  ....*....|
gi 440215109  294 LLKVAETLKI 303
Cdd:cd18226    93 VLEAAKFLDI 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  203 NNYQSNLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDN--PCQHPIIIMRDVSWSDLKALVEFMY 280
Cdd:cd18242     2 NSHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEmsEKGKSEVELQGLTASTMEILLDFVY 81

                          90       100
                  ....*....|....*....|....*...
gi 440215109  281 KGEINVCQDQINPLLKVAETLKIRGLAE 308
Cdd:cd18242    82 TETVHVTVENVQELLPAACLLQLKGVKQ 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  204 NYQSNLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDN---PCQhPIIIMRDVSWSDLKALVEFMY 280
Cdd:cd18268     5 DLSSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNfreSSQ-AKVDLKGIDSDVLDQIVDYVY 83

                          90       100
                  ....*....|....*....|....*...
gi 440215109  281 KGEINVCQDQINPLLKVAETLKIRGLAE 308
Cdd:cd18268    84 TGEILITRDNVLPLMEAASMLQYPKLFE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  224 DVTLSCEGHSIKAHKMVLSACSPYFQALFYD--NPCQHPIIIMRDVSWSDLKALVEFMYKGEINVCQDQINPLLKVAETL 301
Cdd:cd18255    20 DVTLIADGQRFQAHKVVLASCSDYFRAMFTGgmRESSQDEIELKGVSAKGLKHILDFAYTSELTLDLDCIQDVLGAAVHL 99

                  ..
gi 440215109  302 KI 303
Cdd:cd18255   100 QM 101

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  217 LQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQHPIiimRDVSWSDLK-----ALVEFMYKGEINVCQDQI 291
Cdd:cd18314     1 YNDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNL---KEVTLEDVEpeifeTVLKYMYTGQVTLSEENV 77

                          90
                  ....*....|....*....
gi 440215109  292 NPLLKVAETLKIRGLAEVS 310
Cdd:cd18314    78 LDLLMLASKYQVPDLEKLC 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  217 LQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDN--PCQHPIIIMRDVSWSDLKALVEFMYKGEINVCQDQINPL 294
Cdd:cd18336    14 LQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDvrEAKQEEIKMEGVDPDALKALVHYAYTGVLELKEDTIESL 93

                          90
                  ....*....|....*
gi 440215109  295 LKVAETLKIRGLAEV 309
Cdd:cd18336    94 LAAACLLQLSQVIDV 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  208 NLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDN--PCQHPIIIMRDVSWSDLKALVEFMYKGEIN 285
Cdd:cd18253     4 SILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDhrESREMLVEINGILAEAMDCFLQYVYTGKVK 83

                          90       100
                  ....*....|....*....|....*.
gi 440215109  286 VCQDQINPLLKVAETLKIRGLAEVSA 311
Cdd:cd18253    84 ITTENVQYLFETSSLFQISPLRDACA 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  208 NLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDN--PCQHPIIIMRDVSWSDLKALVEFMYKGEIN 285
Cdd:cd18276     7 TLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGlmECSQREVVLHDITAESVSIILNYMYSSDLH 86

                  ....*.
gi 440215109  286 VCQDQI 291
Cdd:cd18276    87 LTNSNV 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 440215109  213 FDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDnpcqhPI-------IIMRDVSWSDLKALVEFMYKGEI 284
Cdd:cd18280     5 FGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFG-----PMreenegeIVIEDVEPPVFKALLHFIYKDEL 78

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  207 SNLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDN--PCQHPIIIMRDVSWSDLKALVEFMYKGEI 284
Cdd:cd18286     2 SRLGKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSwaESNSSEITLTGVSHAAVSFVLLFIYGGVL 81

                          90       100
                  ....*....|....*....|....*.
gi 440215109  285 NVCQDQ-INPLLKVAETLKIRGLAEV 309
Cdd:cd18286    82 DLPDDVnLGELLSLADMYGLDGLKDV 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  222 FVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQH--PIIIMRDVSWSDLKALVEFMYKGEINVCQDQINPLLKVAE 299
Cdd:cd18259    32 LSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESisARVEIKDVDPAVMESLIDFAYTGKLTINQGNVEALIRTSN 111

                          90
                  ....*....|
gi 440215109  300 TLKIRGLAEV 309
Cdd:cd18259   112 RLQFPTVRKV 121

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  209 LTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQH-------PIIIMRDVSWSDLKALVEFMYK 281
Cdd:cd18296     4 LDELPFPPEQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESeenngsiPVVTLHDVSPEVFAIVLYYIYT 83

                          90       100
                  ....*....|....*....|....*
gi 440215109  282 GEINVCQDQINPLLKVAETLKIRGL 306
Cdd:cd18296    84 DDTDLPPENAYDVLYVADMYLLPGL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  213 FDELLQSESFVDVTLSC-EGHSIKAHKMVLSACSPYFQALFYDNPCQ--HPIIIMRDVSWSDLKALVEFMYKGEINVCQD 289
Cdd:cd18252    12 FRTFYLDGLFTDITLQCaSGQIFHCHKAALAACSSYFKVMFTADMKEksNNVIKLSGIDHDILEALVNYVYTSQICITER 91

                          90
                  ....*....|...
gi 440215109  290 QINPLLKVAETLK 302
Cdd:cd18252    92 NVQSLLEAADLLQ 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  224 DVTLSCEGHSIKAHKMVLSACSPYFQALFYDN--PCQHPIIIMRDVSWSDLKALVEFMYKGEINVCQDQINPLLKVAETL 301
Cdd:cd18249    25 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGElaESRQTEVTIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLL 104

                  ....*...
gi 440215109  302 KIRGLAEV 309
Cdd:cd18249   105 QLAEIQEV 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215109  224 DVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQHPIIIMRDV-SWSDLKALVEFMYKGEINVCQDQINPLLKVAETLK 302
Cdd:cd18233    20 DCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNDVFHLDIkNVGGIGQILDFMYTSHLDLNQDNVQVMLDIAQCLQ 99

                  .
gi 440215109  303 I 303
Cdd:cd18233   100 V 100