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Conserved domains on  [gi|514351544|gb|AGO49953|]
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Toll-like receptor 15, partial [Philesturnus carunculatus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1000960)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15370 super family cl33128
type III secretion system effector E3 ubiquitin transferase SlrP;
216-408 1.76e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


The actual alignment was detected with superfamily member PRK15370:

Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 87.83  E-value: 1.76e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 216 IYTAFSDSGNALPtcIPPPGTVHINAISFVRNEAGTLIESLPAKVKHLGMSNCSIVELPEWFAETVEELlflDLSSNHIS 295
Cdd:PRK15370 201 ITTLILDNNELKS--LPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSL---DLFHNKIS 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 296 ALP-NFPPSLQHLDISNNDIKVIPPSLKSlsNLTTLRIQNNKIMDMhTEYFPSALKKCDFSKNKVKVL--SLTNALEKLe 372
Cdd:PRK15370 276 CLPeNLPEELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTAL-PETLPPGLKTLEAGENALTSLpaSLPPELQVL- 351

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 514351544 373 ylNVSGNLITHLePTSRLPTLASLDSSHNLIPELPD 408
Cdd:PRK15370 352 --DVSKNQITVL-PETLPPTITTLDVSRNALTNLPE 384
 
Name Accession Description Interval E-value
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
216-408 1.76e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 87.83  E-value: 1.76e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 216 IYTAFSDSGNALPtcIPPPGTVHINAISFVRNEAGTLIESLPAKVKHLGMSNCSIVELPEWFAETVEELlflDLSSNHIS 295
Cdd:PRK15370 201 ITTLILDNNELKS--LPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSL---DLFHNKIS 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 296 ALP-NFPPSLQHLDISNNDIKVIPPSLKSlsNLTTLRIQNNKIMDMhTEYFPSALKKCDFSKNKVKVL--SLTNALEKLe 372
Cdd:PRK15370 276 CLPeNLPEELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTAL-PETLPPGLKTLEAGENALTSLpaSLPPELQVL- 351

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 514351544 373 ylNVSGNLITHLePTSRLPTLASLDSSHNLIPELPD 408
Cdd:PRK15370 352 --DVSKNQITVL-PETLPPTITTLDVSRNALTNLPE 384
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
258-408 7.57e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 7.57e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 258 AKVKHLGMSNCSIVELPEWFAEtVEELLFLDLSSNHISALPNF---PPSLQHLDISNNDIKVIPPSLKSLSNLTTLRIQN 334
Cdd:COG4886  113 TNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEPlgnLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSN 191

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514351544 335 NKIMDMHTE-YFPSALKKCDFSKNKVKVLSLT-NALEKLEYLNVSGNLITHLEPTSRLPTLASLDSSHNLIPELPD 408
Cdd:COG4886  192 NQITDLPEPlGNLTNLEELDLSGNQLTDLPEPlANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPP 267
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 287-403 3.92e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 3.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 287 LDLSSNHISALPNFP--PSLQHLDISNNDIKVIPpSLKSLSNLTTLRIQNNKIMDM-HTEYFPSaLKKCDFSKNKVKVL- 362
Cdd:cd21340    7 LYLNDKNITKIDNLSlcKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIeNLENLVN-LKKLYLGGNRISVVe 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 363 -----------------------------SLTNALEKLEYLNVSGNLITHLEPTSRLPTLASLDSSHNLI 403
Cdd:cd21340   85 glenltnleelhienqrlppgekltfdprSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQI 154
LRR_8 pfam13855
Leucine rich repeat;
287-337 2.28e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 2.28e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 514351544  287 LDLSSNHISALP----NFPPSLQHLDISNNDIKVIPP-SLKSLSNLTTLRIQNNKI 337
Cdd:pfam13855   6 LDLSNNRLTSLDdgafKGLSNLKVLDLSNNLLTTLSPgAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
216-408 1.76e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 87.83  E-value: 1.76e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 216 IYTAFSDSGNALPtcIPPPGTVHINAISFVRNEAGTLIESLPAKVKHLGMSNCSIVELPEWFAETVEELlflDLSSNHIS 295
Cdd:PRK15370 201 ITTLILDNNELKS--LPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSL---DLFHNKIS 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 296 ALP-NFPPSLQHLDISNNDIKVIPPSLKSlsNLTTLRIQNNKIMDMhTEYFPSALKKCDFSKNKVKVL--SLTNALEKLe 372
Cdd:PRK15370 276 CLPeNLPEELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTAL-PETLPPGLKTLEAGENALTSLpaSLPPELQVL- 351

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 514351544 373 ylNVSGNLITHLePTSRLPTLASLDSSHNLIPELPD 408
Cdd:PRK15370 352 --DVSKNQITVL-PETLPPTITTLDVSRNALTNLPE 384
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
140-359 5.46e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 86.29  E-value: 5.46e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 140 KLTINILNAESFCKFPSHQLLFLNLSNNPIKSL--------DTL------------CLPSSIKEIDLSFTNISRIPLNFA 199
Cdd:PRK15370 182 ELRLKILGLTTIPACIPEQITTLILDNNELKSLpenlqgniKTLyansnqltsipaTLPDTIQEMELSINRITELPERLP 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 200 GKLFNLEkmyvqgnhfiytAFSDSGNALPTCIPPpgtvHINAISFVRNEAGTLIESLPAKVKHLGMSNCSIVELPEWFAE 279
Cdd:PRK15370 262 SALQSLD------------LFHNKISCLPENLPE----ELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPP 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 280 TVEellFLDLSSNHISALP-NFPPSLQHLDISNNDIKVIPPSLKslSNLTTLRIQNNKIMDMhTEYFPSALKKCDFSKNK 358
Cdd:PRK15370 326 GLK---TLEAGENALTSLPaSLPPELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNL-PENLPAALQIMQASRNN 399


                 .
gi 514351544 359 V 359
Cdd:PRK15370 400 L 400
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
258-408 7.57e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 7.57e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 258 AKVKHLGMSNCSIVELPEWFAEtVEELLFLDLSSNHISALPNF---PPSLQHLDISNNDIKVIPPSLKSLSNLTTLRIQN 334
Cdd:COG4886  113 TNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEPlgnLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSN 191

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514351544 335 NKIMDMHTE-YFPSALKKCDFSKNKVKVLSLT-NALEKLEYLNVSGNLITHLEPTSRLPTLASLDSSHNLIPELPD 408
Cdd:COG4886  192 NQITDLPEPlGNLTNLEELDLSGNQLTDLPEPlANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPP 267
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
76-385 3.96e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.43  E-value: 3.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544  76 LDLSHSNLTTEELMLKLDEDLCQAQLGRILELDISHNNVEMDLLSLFALFFPMENTLSIDASSNKLTINILNAESFCKFP 155
Cdd:COG4886   15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 156 SHQLLFLNLSNNpikslDTLCLPSSIKEIDLSFTNISRIPLNFAgKLFNLEKMYVQGNHFiytafsdsgnalpTCIPPPg 235
Cdd:COG4886   95 LTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLPEELA-NLTNLKELDLSNNQL-------------TDLPEP- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 236 tvhinaisfvrneagtlIESLPaKVKHLGMSNCSIVELPEWFAEtVEELLFLDLSSNHISALPNF---PPSLQHLDISNN 312
Cdd:COG4886  155 -----------------LGNLT-NLKSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITDLPEPlgnLTNLEELDLSGN 215

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351544 313 DIKVIPPSLKSLSNLTTLRIQNNKIMDMHTEYFPSALKKCDFSKNKVKVLSLTNALEKLEYLNVSGNLITHLE 385
Cdd:COG4886  216 QLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
18-324 1.34e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.81  E-value: 1.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544  18 SAPAKELPRSGvlSLLQILNPRLRRSTGNLlRRGERNATALPTATPEPTLcgtpingTLDLSHSNLtteelmLKLDEDLc 97
Cdd:PRK15370 156 EAPAKEAANRE--EAVQRMRDCLKNNKTEL-RLKILGLTTIPACIPEQIT-------TLILDNNEL------KSLPENL- 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544  98 qaqLGRILELDISHNNvemdllsLFALFFPMENTLSI-DASSNKLTinilnaesfcKFPSH---QLLFLNLSNNPIKSL- 172
Cdd:PRK15370 219 ---QGNIKTLYANSNQ-------LTSIPATLPDTIQEmELSINRIT----------ELPERlpsALQSLDLFHNKISCLp 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 173 DTLclPSSIKEIDLSFTNISRIPLNFAGKLFNLekmyvqgnhfiyTAFSDSGNALPTCIPPpgtvHINAISFVRNEAGTL 252
Cdd:PRK15370 279 ENL--PEELRYLSVYDNSIRTLPAHLPSGITHL------------NVQSNSLTALPETLPP----GLKTLEAGENALTSL 340

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351544 253 IESLPAKVKHLGMSNCSIVELPEWFAETVEELlflDLSSNHISALP-NFPPSLQHLDISNNDIKVIPPSLKSL 324
Cdd:PRK15370 341 PASLPPELQVLDVSKNQITVLPETLPPTITTL---DVSRNALTNLPeNLPAALQIMQASRNNLVRLPESLPHF 410
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-403 6.07e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.96  E-value: 6.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544  73 NGTLDLSHSNLTTEELMLKLDEDLCQAQLGRILELDISHNNVEMDLLSLFALFFPMENTLSIDASSNKLTINILNAESFC 152
Cdd:COG4886   31 LLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 153 KFPshQLLFLNLSNNPIKSL-DTLCLPSSIKEIDLSFTNISRIPLNFaGKLFNLEKMYVQGNHFiytafsdsgnalpTCI 231
Cdd:COG4886  111 NLT--NLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQL-------------TDL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 232 PPPgtvhinaisfvrneagtlIESLPaKVKHLGMSNCSIVELPEWFAEtVEELLFLDLSSNHISALPNF---PPSLQHLD 308
Cdd:COG4886  175 PEE------------------LGNLT-NLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTDLPEPlanLTNLETLD 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 309 ISNNDIKVIPpSLKSLSNLTTLRIQNNKIMDMHTEYFPSALKKCDFSKNKVKVLSLTNALEKLEYLNVSGNLITHLEPTS 388
Cdd:COG4886  235 LSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313

                        330
                 ....*....|....*
gi 514351544 389 RLPTLASLDSSHNLI 403
Cdd:COG4886  314 LILLLLLTTLLLLLL 328
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 287-403 3.92e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 3.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 287 LDLSSNHISALPNFP--PSLQHLDISNNDIKVIPpSLKSLSNLTTLRIQNNKIMDM-HTEYFPSaLKKCDFSKNKVKVL- 362
Cdd:cd21340    7 LYLNDKNITKIDNLSlcKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIeNLENLVN-LKKLYLGGNRISVVe 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 363 -----------------------------SLTNALEKLEYLNVSGNLITHLEPTSRLPTLASLDSSHNLI 403
Cdd:cd21340   85 glenltnleelhienqrlppgekltfdprSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQI 154
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 258-403 8.71e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 8.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 258 AKVKHLGMSNCSIVELPEwfAETVEELLFLDLSSNHISALPNFP--PSLQHLDISNNDIKVIPPsLKSLSNLTTLRIQNN 335
Cdd:cd21340    2 KRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIENLEflTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 336 KI------------MDMHTEY----------F----PSALKKC----DFSKNKVKVLSLTNALEKLEYLNVSGNLITHLE 385
Cdd:cd21340   79 RIsvveglenltnlEELHIENqrlppgekltFdprsLAALSNSlrvlNISGNNIDSLEPLAPLRNLEQLDASNNQISDLE 158

                        170       180
                 ....*....|....*....|..
gi 514351544 386 PT----SRLPTLASLDSSHNLI 403
Cdd:cd21340  159 ELldllSSWPSLRELDLTGNPV 180
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
227-409 8.91e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 47.85  E-value: 8.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 227 LPTCIPppgtVHINAISFVRNEAGTLiESLPAKVKHLGMSNCSIVELPEWFAETVEELLF----------------LDLS 290
Cdd:PRK15387 216 LPDCLP----AHITTLVIPDNNLTSL-PALPPELRTLEVSGNQLTSLPVLPPGLLELSIFsnplthlpalpsglckLWIF 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 291 SNHISALPNFPPSLQHLDISNNDIKVIPpslKSLSNLTTLRIQNNKIMDMHTeyFPSALKKCDFSKNKVKVL-SLTNALE 369
Cdd:PRK15387 291 GNQLTSLPVLPPGLQELSVSDNQLASLP---ALPSELCKLWAYNNQLTSLPT--LPSGLQELSVSDNQLASLpTLPSELY 365

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 514351544 370 KLEYLN-----------------VSGNLITHLEP-TSRLPTLASLDSSHNLIPELPDG 409
Cdd:PRK15387 366 KLWAYNnrltslpalpsglkeliVSGNRLTSLPVlPSELKELMVSGNRLTSLPMLPSG 423
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 282-383 1.19e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 282 EELLFLDLSSNHISalpnfpPSLQHLDISNNDIKVIPPsLKSLSNLTTLRIQNNKIMDMHteyfpsalkkcdfsknkvKV 361
Cdd:cd21340  106 EKLTFDPRSLAALS------NSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLE------------------EL 160

                         90       100
                 ....*....|....*....|..
gi 514351544 362 LSLTNALEKLEYLNVSGNLITH 383
Cdd:cd21340  161 LDLLSSWPSLRELDLTGNPVCK 182
LRR_8 pfam13855
Leucine rich repeat;
287-337 2.28e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 2.28e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 514351544  287 LDLSSNHISALP----NFPPSLQHLDISNNDIKVIPP-SLKSLSNLTTLRIQNNKI 337
Cdd:pfam13855   6 LDLSNNRLTSLDdgafKGLSNLKVLDLSNNLLTTLSPgAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 101-401 3.27e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 3.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 101 LGRILELDISHNNVEMDLLSLFAlffPMENTLSIDASSNKLTINIlnAESFCKFPSHQLLFL---NLSNNPIKSLDTlcl 177
Cdd:PLN00113 283 LQKLISLDLSDNSLSGEIPELVI---QLQNLEILHLFSNNFTGKI--PVALTSLPRLQVLQLwsnKFSGEIPKNLGK--- 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 178 PSSIKEIDLSFTNIS-RIPlnfagklfnlEKMYVQGNHFIYTAFSdsgNALPTCIPPPGTVhINAISFVRNEAGTLIESL 256
Cdd:PLN00113 355 HNNLTVLDLSTNNLTgEIP----------EGLCSSGNLFKLILFS---NSLEGEIPKSLGA-CRSLRRVRLQDNSFSGEL 420

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 257 PAK------VKHLGMSNCSI---VELPEWfaeTVEELLFLDLSSNHISA-LPNFPPS--LQHLDISNNDIK-VIPPSLKS 323
Cdd:PLN00113 421 PSEftklplVYFLDISNNNLqgrINSRKW---DMPSLQMLSLARNKFFGgLPDSFGSkrLENLDLSRNQFSgAVPRKLGS 497

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 324 LSNLTTLRIQNNKImdmhTEYFPSALKKCdfsknkvkvlsltnalEKLEYLNVSGNLITHLEPTS--RLPTLASLDSSHN 401
Cdd:PLN00113 498 LSELMQLKLSENKL----SGEIPDELSSC----------------KKLVSLDLSHNQLSGQIPASfsEMPVLSQLDLSQN 557
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
247-339 3.75e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.84  E-value: 3.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 247 NEAGTLIESLPAKVKHLGMSNCSIVELPEWFAETVEellfLDLSSNHISALPNFPPSLQHLDISNNDIKVIPPSLKSLSN 326
Cdd:PRK15387 371 NNRLTSLPALPSGLKELIVSGNRLTSLPVLPSELKE----LMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSS 446

                         90
                 ....*....|...
gi 514351544 327 LTTLRIQNNKIMD 339
Cdd:PRK15387 447 ETTVNLEGNPLSE 459
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 103-407 1.16e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 103 RILELDISHNNVEMDLLSLFalfFPMENTLSIDASSNKLTINILNAESFCkfpSHQLLFLNLSNN----PIKSLDTLCLP 178
Cdd:PLN00113  70 RVVSIDLSGKNISGKISSAI---FRLPYIQTINLSNNQLSGPIPDDIFTT---SSSLRYLNLSNNnftgSIPRGSIPNLE 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 179 SsikeIDLSFTNIS-RIPLNFaGKLFNLEkmyvqgnhfiytaFSD-SGNALPTCIPPPGTvHINAISFVRNEAGTLIESL 256
Cdd:PLN00113 144 T----LDLSNNMLSgEIPNDI-GSFSSLK-------------VLDlGGNVLVGKIPNSLT-NLTSLEFLTLASNQLVGQI 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 257 PA--------KVKHLGMSNCSiVELPewfaetveellfldlssNHISALPnfppSLQHLD-ISNNDIKVIPPSLKSLSNL 327
Cdd:PLN00113 205 PRelgqmkslKWIYLGYNNLS-GEIP-----------------YEIGGLT----SLNHLDlVYNNLTGPIPSSLGNLKNL 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544 328 TTLRIQNNKIMDM--HTEYFPSALKKCDFSKNKV--KVLSLTNALEKLEYLNVSGNLITHLEPT--SRLPTLASLDS-SH 400
Cdd:PLN00113 263 QYLFLYQNKLSGPipPSIFSLQKLISLDLSDNSLsgEIPELVIQLQNLEILHLFSNNFTGKIPValTSLPRLQVLQLwSN 342


                 ....*..
gi 514351544 401 NLIPELP 407
Cdd:PLN00113 343 KFSGEIP 349
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 284-341 1.73e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 1.73e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351544 284 LLFLDLSSNHISALPNFPP--SLQHLDISNN---DIKVIPPSLKSLSNLTTLRIQNNKIMDMH 341
Cdd:cd21340  122 LRVLNISGNNIDSLEPLAPlrNLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 302-335 3.05e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 3.05e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 514351544  302 PSLQHLDISNNDIKVIPPsLKSLSNLTTLRIQNN 335
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGN 33
LRR_8 pfam13855
Leucine rich repeat;
325-403 3.09e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 3.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351544  325 SNLTTLRIQNNKIMDMHTEYFpsalkkcdfsknkvkvlsltNALEKLEYLNVSGNLITHLEPTS--RLPTLASLDSSHNL 402
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAF--------------------KGLSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGNR 60


                  .
gi 514351544  403 I 403
Cdd:pfam13855  61 L 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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