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Conserved domains on  [gi|514351548|gb|AGO49955|]
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Toll-like receptor 15, partial [Porphyrio hochstetteri]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-366 2.29e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 2.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548  81 QAQLDGILELNISHSALEMDLLSLFTLFLPMKNMRSVDASYNKLTINILDVSAICAFPDSQLLFVNLSNN-PINSLDTLc 159
Cdd:COG4886   37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNeELSNLTNL- 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 160 lpstvTVIDLSFTNISQIPQNFAQkMLNLEHMYVQGNHFiytarpaasnamenvppgtvhinaisfvrNQAGTPIESLPK 239
Cdd:COG4886  116 -----ESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQL-----------------------------TDLPEPLGNLTN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 240 kVKHLEMANCSIVELPEWFAGtMEELLFLDLSSNRISVLPDL---PSSLQYLDLSNGDIEAIPPGFKSVSNLTVVNIQNN 316
Cdd:COG4886  161 -LKSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITDLPEPlgnLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNN 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 514351548 317 KITEMhPEYFPLT-LTRCDFSKNKLHTLPLTDALERLEYLNISGNLITRLE 366
Cdd:COG4886  239 QLTDL-PELGNLTnLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-366 2.29e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 2.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548  81 QAQLDGILELNISHSALEMDLLSLFTLFLPMKNMRSVDASYNKLTINILDVSAICAFPDSQLLFVNLSNN-PINSLDTLc 159
Cdd:COG4886   37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNeELSNLTNL- 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 160 lpstvTVIDLSFTNISQIPQNFAQkMLNLEHMYVQGNHFiytarpaasnamenvppgtvhinaisfvrNQAGTPIESLPK 239
Cdd:COG4886  116 -----ESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQL-----------------------------TDLPEPLGNLTN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 240 kVKHLEMANCSIVELPEWFAGtMEELLFLDLSSNRISVLPDL---PSSLQYLDLSNGDIEAIPPGFKSVSNLTVVNIQNN 316
Cdd:COG4886  161 -LKSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITDLPEPlgnLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNN 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 514351548 317 KITEMhPEYFPLT-LTRCDFSKNKLHTLPLTDALERLEYLNISGNLITRLE 366
Cdd:COG4886  239 QLTDL-PELGNLTnLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
160-369 1.70e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.81  E-value: 1.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 160 LPSTVTVIDLSFTNISQIPQNFAQkmlNLEHMYVQGNHFiyTARPAASnamenvpPGTVHINAISfvRNQAGTPIESLPK 239
Cdd:PRK15370 197 IPEQITTLILDNNELKSLPENLQG---NIKTLYANSNQL--TSIPATL-------PDTIQEMELS--INRITELPERLPS 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 240 KVKHLEMANCSIVELPEWFAgtmEELLFLDLSSNRISVLPD-LPSSLQYLDLSNGDI----EAIPPGFKSVS-------- 306
Cdd:PRK15370 263 ALQSLDLFHNKISCLPENLP---EELRYLSVYDNSIRTLPAhLPSGITHLNVQSNSLtalpETLPPGLKTLEagenalts 339

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 307 -------NLTVVNIQNNKITEMhPEYFPLTLTRCDFSKNKLHTLPlTDALERLEYLNISGNLITRLePAS 369
Cdd:PRK15370 340 lpaslppELQVLDVSKNQITVL-PETLPPTITTLDVSRNALTNLP-ENLPAALQIMQASRNNLVRL-PES 406
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 268-364 2.69e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 2.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 268 LDLSSNRISVLPDL--PSSLQYLDLSNgdiEAIPPGFK---------SVSN-LTVVNIQNNKITEMHPeYFPLT-LTRCD 334
Cdd:cd21340   73 LYLGGNRISVVEGLenLTNLEELHIEN---QRLPPGEKltfdprslaALSNsLRVLNISGNNIDSLEP-LAPLRnLEQLD 148

                         90       100       110
                 ....*....|....*....|....*....|....
gi 514351548 335 FSKNKLHTL-PLTDALER---LEYLNISGNLITR 364
Cdd:cd21340  149 ASNNQISDLeELLDLLSSwpsLRELDLTGNPVCK 182
LRR_8 pfam13855
Leucine rich repeat;
283-362 2.56e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548  283 SSLQYLDLSNGDIEAIPPG-FKSVSNLTVVNIQNNKITEMHPEYFpltltrcdfsknklhtlpltDALERLEYLNISGNL 361
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAF--------------------SGLPSLRYLDLSGNR 60


                  .
gi 514351548  362 I 362
Cdd:pfam13855  61 L 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-366 2.29e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 2.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548  81 QAQLDGILELNISHSALEMDLLSLFTLFLPMKNMRSVDASYNKLTINILDVSAICAFPDSQLLFVNLSNN-PINSLDTLc 159
Cdd:COG4886   37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNeELSNLTNL- 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 160 lpstvTVIDLSFTNISQIPQNFAQkMLNLEHMYVQGNHFiytarpaasnamenvppgtvhinaisfvrNQAGTPIESLPK 239
Cdd:COG4886  116 -----ESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQL-----------------------------TDLPEPLGNLTN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 240 kVKHLEMANCSIVELPEWFAGtMEELLFLDLSSNRISVLPDL---PSSLQYLDLSNGDIEAIPPGFKSVSNLTVVNIQNN 316
Cdd:COG4886  161 -LKSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITDLPEPlgnLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNN 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 514351548 317 KITEMhPEYFPLT-LTRCDFSKNKLHTLPLTDALERLEYLNISGNLITRLE 366
Cdd:COG4886  239 QLTDL-PELGNLTnLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
231-371 3.41e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 3.41e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 231 GTPIESLP------KKVKHLEMANCSIVELPEWFAGtMEELLFLDLSSNRISVLPD----LPSsLQYLDLSNGDIEAIPP 300
Cdd:COG4886  122 GNQLTDLPeelanlTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDLPEelgnLTN-LKELDLSNNQITDLPE 199

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514351548 301 GFKSVSNLTVVNIQNNKITEMHPEYFPLT-LTRCDFSKNKLHTLPLTDALERLEYLNISGNLITRLEPASAL 371
Cdd:COG4886  200 PLGNLTNLEELDLSGNQLTDLPEPLANLTnLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANL 271
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
160-369 1.70e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.81  E-value: 1.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 160 LPSTVTVIDLSFTNISQIPQNFAQkmlNLEHMYVQGNHFiyTARPAASnamenvpPGTVHINAISfvRNQAGTPIESLPK 239
Cdd:PRK15370 197 IPEQITTLILDNNELKSLPENLQG---NIKTLYANSNQL--TSIPATL-------PDTIQEMELS--INRITELPERLPS 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 240 KVKHLEMANCSIVELPEWFAgtmEELLFLDLSSNRISVLPD-LPSSLQYLDLSNGDI----EAIPPGFKSVS-------- 306
Cdd:PRK15370 263 ALQSLDLFHNKISCLPENLP---EELRYLSVYDNSIRTLPAhLPSGITHLNVQSNSLtalpETLPPGLKTLEagenalts 339

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 307 -------NLTVVNIQNNKITEMhPEYFPLTLTRCDFSKNKLHTLPlTDALERLEYLNISGNLITRLePAS 369
Cdd:PRK15370 340 lpaslppELQVLDVSKNQITVL-PETLPPTITTLDVSRNALTNLP-ENLPAALQIMQASRNNLVRL-PES 406
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
260-368 1.86e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 1.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 260 GTMEELLFLDLSSNRISVLPDL---PSSLQYLDLSNGDIEAIPPGFKSVSNLTVVNIQNNKITEMHPEYFPLT-LTRCDF 335
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPEElanLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDL 189

                         90       100       110
                 ....*....|....*....|....*....|....
gi 514351548 336 SKNKLHTLPLT-DALERLEYLNISGNLITRLEPA 368
Cdd:COG4886  190 SNNQITDLPEPlGNLTNLEELDLSGNQLTDLPEP 223
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-346 2.37e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 2.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548  56 NGTLDLSNSKLSEEELMLKLDPDHCQAQLDGILELNISHSALEMDLLSLFTLFLPMKNMRSVDASYNKLTINILDVSAIC 135
Cdd:COG4886   31 LLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 136 AFpdSQLLFVNLSNNPINSL-DTLCLPSTVTVIDLSFTNISQIPQNFAQkMLNLEHMYVQGNHFiytarpaasnamENVP 214
Cdd:COG4886  111 NL--TNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQL------------TDLP 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 215 PgtvhinaisfvrnqagtPIESLPKkVKHLEMANCSIVELPEWFAGtMEELLFLDLSSNRISVLPD-LP--SSLQYLDLS 291
Cdd:COG4886  176 E-----------------ELGNLTN-LKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTDLPEpLAnlTNLETLDLS 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 514351548 292 NGDIEAIPpGFKSVSNLTVVNIQNNKITEMHPEYFPLTLTRCDFSKNKLHTLPLT 346
Cdd:COG4886  237 NNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLK 290
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
113-320 1.54e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.87  E-value: 1.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 113 NMRSVDASYNKLT---------INILDVSA--ICAFPD---SQLLFVNLSNNPINSL-DTLclPSTVTVIDLSFTNISQI 177
Cdd:PRK15370 221 NIKTLYANSNQLTsipatlpdtIQEMELSInrITELPErlpSALQSLDLFHNKISCLpENL--PEELRYLSVYDNSIRTL 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 178 PQNFAQKMLnleHMYVQGNHFiyTARPaasnamENVPPGtvhINAISFVRNQAGTPIESLPKKVKHLEMANCSIVELPEW 257
Cdd:PRK15370 299 PAHLPSGIT---HLNVQSNSL--TALP------ETLPPG---LKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPET 364

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 514351548 258 FAGTMEEllfLDLSSNRISVLPD-LPSSLQYLDLSNGDIEAIP---PGFKSVS-NLTVVNIQNNKITE 320
Cdd:PRK15370 365 LPPTITT---LDVSRNALTNLPEnLPAALQIMQASRNNLVRLPeslPHFRGEGpQPTRIIVEYNPFSE 429
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
236-365 1.10e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.10  E-value: 1.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 236 SLPKKVKHLEMANCSIVELPEWFAGTMEELL------------------FLDLSSNRISVLPD-LPSSLQYLDLSNGDI- 295
Cdd:PRK15370 196 CIPEQITTLILDNNELKSLPENLQGNIKTLYansnqltsipatlpdtiqEMELSINRITELPErLPSALQSLDLFHNKIs 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 296 ---EAIPPGFKSV---------------SNLTVVNIQNNKITEMhPEYFPLTLTRCDFSKNKLHTLPLTDALErLEYLNI 357
Cdd:PRK15370 276 clpENLPEELRYLsvydnsirtlpahlpSGITHLNVQSNSLTAL-PETLPPGLKTLEAGENALTSLPASLPPE-LQVLDV 353


                 ....*...
gi 514351548 358 SGNLITRL 365
Cdd:PRK15370 354 SKNQITVL 361
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
159-365 2.39e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 52.86  E-value: 2.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 159 CLPSTVTVIDLSFTNISQIPQnFAQKMLNLEhmyVQGNHFiyTARPAA----------SNAMENVPPGTVHINAISFVRN 228
Cdd:PRK15387 219 CLPAHITTLVIPDNNLTSLPA-LPPELRTLE---VSGNQL--TSLPVLppgllelsifSNPLTHLPALPSGLCKLWIFGN 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 229 QAgTPIESLPKKVKHLEMANCSIVELPewfaGTMEELLFLDLSSNRISVLPDLPSSLQYLDLSNGDIEAIPpgfKSVSNL 308
Cdd:PRK15387 293 QL-TSLPVLPPGLQELSVSDNQLASLP----ALPSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLP---TLPSEL 364

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 514351548 309 TVVNIQNNKITEMhpEYFPLTLTRCDFSKNKLHTLPLTDAleRLEYLNISGNLITRL 365
Cdd:PRK15387 365 YKLWAYNNRLTSL--PALPSGLKELIVSGNRLTSLPVLPS--ELKELMVSGNRLTSL 417
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 268-364 2.69e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 2.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 268 LDLSSNRISVLPDL--PSSLQYLDLSNgdiEAIPPGFK---------SVSN-LTVVNIQNNKITEMHPeYFPLT-LTRCD 334
Cdd:cd21340   73 LYLGGNRISVVEGLenLTNLEELHIEN---QRLPPGEKltfdprslaALSNsLRVLNISGNNIDSLEP-LAPLRnLEQLD 148

                         90       100       110
                 ....*....|....*....|....*....|....
gi 514351548 335 FSKNKLHTL-PLTDALER---LEYLNISGNLITR 364
Cdd:cd21340  149 ASNNQISDLeELLDLLSSwpsLRELDLTGNPVCK 182
LRR_8 pfam13855
Leucine rich repeat;
283-362 2.56e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548  283 SSLQYLDLSNGDIEAIPPG-FKSVSNLTVVNIQNNKITEMHPEYFpltltrcdfsknklhtlpltDALERLEYLNISGNL 361
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAF--------------------SGLPSLRYLDLSGNR 60


                  .
gi 514351548  362 I 362
Cdd:pfam13855  61 L 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
58-371 1.69e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 1.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548  58 TLDLSNSKLSEEELMLkldpdhcqAQLDGILELNISHSALEmdllSLFTLFLPMKNMRSVDASYNKLTinilDVSAIcAF 137
Cdd:COG4886  117 SLDLSGNQLTDLPEEL--------ANLTNLKELDLSNNQLT----DLPEPLGNLTNLKSLDLSNNQLT----DLPEE-LG 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 138 PDSQLLFVNLSNNPINSL-DTLCLPSTVTVIDLSFTNISQIPQNFAQkMLNLEHMYVQGNhfiytarpaasnamenvppg 216
Cdd:COG4886  180 NLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNN-------------------- 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 217 tvhinaisfvrnqagtPIESLP-----KKVKHLEMANCSIVELPEwfAGTMEELLFLDLSSNRISVLPDLPSSLQYLDLS 291
Cdd:COG4886  239 ----------------QLTDLPelgnlTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 292 NGDIEAIPPGFKSVSNLTVVNIQNNKITEMHPEYFPLTLTRCDFSKNKLHTLPLTDALERLEYLNISGNLITRLEPASAL 371
Cdd:COG4886  301 LLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLL 380
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
90-320 1.89e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 43.61  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548  90 LNISHSALEM--DLLS--LFTLFLPMKNMRSVDA---SYNKLTINILDVSAICAFPDSqLLFVNLSNNPINSLDTLclPS 162
Cdd:PRK15387 206 LNVGESGLTTlpDCLPahITTLVIPDNNLTSLPAlppELRTLEVSGNQLTSLPVLPPG-LLELSIFSNPLTHLPAL--PS 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 163 TVT---VIDLSFTNISQIPQNfaqkmlnLEHMYVQGNHFI-YTARP-------AASNAMENVPPGTVHINAISFVRNQAG 231
Cdd:PRK15387 283 GLCklwIFGNQLTSLPVLPPG-------LQELSVSDNQLAsLPALPselcklwAYNNQLTSLPTLPSGLQELSVSDNQLA 355

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 232 TpIESLPKKVKHLEMANCSIVELPEWFAGTME----------------ELLFLDLSSNRISVLPDLPSSLQYLDLSNGDI 295
Cdd:PRK15387 356 S-LPTLPSELYKLWAYNNRLTSLPALPSGLKElivsgnrltslpvlpsELKELMVSGNRLTSLPMLPSGLLSLSVYRNQL 434

                        250       260
                 ....*....|....*....|....*
gi 514351548 296 EAIPPGFKSVSNLTVVNIQNNKITE 320
Cdd:PRK15387 435 TRLPESLIHLSSETTVNLEGNPLSE 459
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 160-336 2.92e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 42.94  E-value: 2.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548  160 LPSTVTVIDLSFTNISQIPQNFAQKMLNLEHMYVQGNHFIYTARPAASNAMENVPPGTVHI---NAISFVrnQAGTPIES 236
Cdd:PLN03210  723 ISTNISWLDLDETAIEEFPSNLRLENLDELILCEMKSEKLWERVQPLTPLMTMLSPSLTRLflsDIPSLV--ELPSSIQN 800

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548  237 LpKKVKHLEMANC-SIVELPEWFagTMEELLFLDLSS-NRISVLPDLPSSLQYLDLSNGDIEAIPPGFKSVSNLTVVNIQ 314
Cdd:PLN03210  801 L-HKLEHLEIENCiNLETLPTGI--NLESLESLDLSGcSRLRTFPDISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDMN 877

                         170       180
                  ....*....|....*....|....
gi 514351548  315 N-NKITEMHPEYFPLT-LTRCDFS 336
Cdd:PLN03210  878 GcNNLQRVSLNISKLKhLETVDFS 901
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 268-366 5.31e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 5.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 268 LDLSSNRISVLPDLPS--SLQYLDLSNGDIEAIPpGFKSVSNLTVVNIQNNKITEMhpEYFpltltrcdfsknklhtlpl 345
Cdd:cd21340    7 LYLNDKNITKIDNLSLckNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKI--ENL------------------- 64

                         90       100
                 ....*....|....*....|.
gi 514351548 346 tDALERLEYLNISGNLITRLE 366
Cdd:cd21340   65 -ENLVNLKKLYLGGNRISVVE 84
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 239-371 4.32e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 4.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 239 KKVKHLEMANCSIVELPEwfAGTMEELLFLDLSSNRISVLPDLPS--SLQYLDLSNGDIEAIPpGFKSVSNLTVVNIQNN 316
Cdd:cd21340    2 KRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIENLEFltNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351548 317 KIT------------EMH------PEYFPLTltrcdFSKNKLHTLpltdaLERLEYLNISGNLITRLEPASAL 371
Cdd:cd21340   79 RISvveglenltnleELHienqrlPPGEKLT-----FDPRSLAAL-----SNSLRVLNISGNNIDSLEPLAPL 141
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 107-340 4.73e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.06  E-value: 4.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 107 LFLPMKNMRSVDASYNKLTINIldVSAICAFPDSQLLFVnLSNN-----PINsldtLCLPSTVTVIDLSFTNIS-QIPQN 180
Cdd:PLN00113 303 LVIQLQNLEILHLFSNNFTGKI--PVALTSLPRLQVLQL-WSNKfsgeiPKN----LGKHNNLTVLDLSTNNLTgEIPEG 375

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 181 FAQkmlnlehmyvQGNHFIYTArpaASNAMEN-VPPGTVHINAISFVRNQAGTPIESLPKK------VKHLEMANCSI-- 251
Cdd:PLN00113 376 LCS----------SGNLFKLIL---FSNSLEGeIPKSLGACRSLRRVRLQDNSFSGELPSEftklplVYFLDISNNNLqg 442

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351548 252 -VELPEWfagTMEELLFLDLSSNRIS-VLPDLPSS--LQYLDLSNGDI-EAIPPGFKSVSNLTVVNIQNNKITEMHPEyf 326
Cdd:PLN00113 443 rINSRKW---DMPSLQMLSLARNKFFgGLPDSFGSkrLENLDLSRNQFsGAVPRKLGSLSELMQLKLSENKLSGEIPD-- 517

                        250       260
                 ....*....|....*....|
gi 514351548 327 plTLTRC------DFSKNKL 340
Cdd:PLN00113 518 --ELSSCkklvslDLSHNQL 535
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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