NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|576236147|gb|AHH28324|]
View 

MADS-box transcription factor, partial [Dalechampia sp. CONN 198500613]

Protein Classification

MADS-box domain-containing protein( domain architecture ID 10083661)

MADS-box domain-containing protein with a K-box coiled-coil region; the MADS-box domain (MCM1, AGAMOUS, DEFICIENS, and SRF, serum response factor) is a conserved DNA-binding/dimerization region present in a variety of transcription factors from three eukaryotic kingdoms, plants, animals, and fungi

Gene Ontology:  GO:0003700
PubMed:  29802068

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 1-64 2.70e-35

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


:

Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 119.58  E-value: 2.70e-35
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 576236147   1 TNRQVTFCKRRNGLLKKAYELSVLCDAEVGLIVFSSRGRLYEYANNSVKATIERYKKATSDSST 64
Cdd:cd00265   14 TNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSSPSMEKIIERYQKTSGSSLW 77
K-box pfam01486
K-box region; The K-box region is commonly found associated with SRF-type transcription ...
 73-158 6.84e-31

K-box region; The K-box region is commonly found associated with SRF-type transcription factors see pfam00319. The K-box is a possible coiled-coil structure. Possible role in multimer formation.


:

Pssm-ID: 460228 [Multi-domain]  Cd Length: 91  Bit Score: 108.70  E-value: 6.84e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576236147   73 VQYYQQESAKLRAQIGNLQNSNRHMLGESLGSLNAKELKNLETKLEKGISRIRSKKNELLFAEIEYMQKREIDLHNNNQL 152
Cdd:pfam01486   6 QENWQQEAAKLKKEIENLQRSQRQLLGEDLSSLSLKELQQLEQQLEKSLKRIRSRKNQLLLEQIEELKKKERILQEENKE 85


                  ....*.
gi 576236147  153 LRAKIA 158
Cdd:pfam01486  86 LRKKLE 91
 
Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 1-64 2.70e-35

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 119.58  E-value: 2.70e-35
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 576236147   1 TNRQVTFCKRRNGLLKKAYELSVLCDAEVGLIVFSSRGRLYEYANNSVKATIERYKKATSDSST 64
Cdd:cd00265   14 TNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSSPSMEKIIERYQKTSGSSLW 77
K-box pfam01486
K-box region; The K-box region is commonly found associated with SRF-type transcription ...
 73-158 6.84e-31

K-box region; The K-box region is commonly found associated with SRF-type transcription factors see pfam00319. The K-box is a possible coiled-coil structure. Possible role in multimer formation.


Pssm-ID: 460228 [Multi-domain]  Cd Length: 91  Bit Score: 108.70  E-value: 6.84e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576236147   73 VQYYQQESAKLRAQIGNLQNSNRHMLGESLGSLNAKELKNLETKLEKGISRIRSKKNELLFAEIEYMQKREIDLHNNNQL 152
Cdd:pfam01486   6 QENWQQEAAKLKKEIENLQRSQRQLLGEDLSSLSLKELQQLEQQLEKSLKRIRSRKNQLLLEQIEELKKKERILQEENKE 85


                  ....*.
gi 576236147  153 LRAKIA 158
Cdd:pfam01486  86 LRKKLE 91
MADS smart00432
MADS domain;
1-44 6.34e-25

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 92.24  E-value: 6.34e-25
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 576236147     1 TNRQVTFCKRRNGLLKKAYELSVLCDAEVGLIVFSSRGRLYEYA 44
Cdd:smart00432  14 TNRQVTFSKRRNGLFKKAHELSVLCDAEVALIVFSPTGKLYEFA 57
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
1-43 3.81e-24

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 90.18  E-value: 3.81e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 576236147    1 TNRQVTFCKRRNGLLKKAYELSVLCDAEVGLIVFSSRGRLYEY 43
Cdd:pfam00319   6 RARQVTFSKRRKGLFKKASELSVLCGAEVAVIVFSPTGKLYTF 48
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 1-98 1.06e-07

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 51.17  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576236147   1 TNRQVTFCKRRNGLLKKAYELSVLCDAEVGLIVFSSRGRLYEYannsvkaTIERYKKATSDSSTTGSVSE--INVQYYQQ 78
Cdd:COG5068   95 TKRSVTFSKRKHGINKKAFELSVLTGTEVLLLVISENGLVHTF-------TTPKLESVVKSLEGKSLIQSpcSNAPSDSS 167

                         90       100
                 ....*....|....*....|
gi 576236147  79 ESAKLRAQIGNLQNSNRHML 98
Cdd:COG5068  168 EEPSSSASFSVDPNDNNPMG 187
 
Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 1-64 2.70e-35

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 119.58  E-value: 2.70e-35
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 576236147   1 TNRQVTFCKRRNGLLKKAYELSVLCDAEVGLIVFSSRGRLYEYANNSVKATIERYKKATSDSST 64
Cdd:cd00265   14 TNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSSPSMEKIIERYQKTSGSSLW 77
K-box pfam01486
K-box region; The K-box region is commonly found associated with SRF-type transcription ...
 73-158 6.84e-31

K-box region; The K-box region is commonly found associated with SRF-type transcription factors see pfam00319. The K-box is a possible coiled-coil structure. Possible role in multimer formation.


Pssm-ID: 460228 [Multi-domain]  Cd Length: 91  Bit Score: 108.70  E-value: 6.84e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576236147   73 VQYYQQESAKLRAQIGNLQNSNRHMLGESLGSLNAKELKNLETKLEKGISRIRSKKNELLFAEIEYMQKREIDLHNNNQL 152
Cdd:pfam01486   6 QENWQQEAAKLKKEIENLQRSQRQLLGEDLSSLSLKELQQLEQQLEKSLKRIRSRKNQLLLEQIEELKKKERILQEENKE 85


                  ....*.
gi 576236147  153 LRAKIA 158
Cdd:pfam01486  86 LRKKLE 91
MADS smart00432
MADS domain;
1-44 6.34e-25

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 92.24  E-value: 6.34e-25
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 576236147     1 TNRQVTFCKRRNGLLKKAYELSVLCDAEVGLIVFSSRGRLYEYA 44
Cdd:smart00432  14 TNRQVTFSKRRNGLFKKAHELSVLCDAEVALIVFSPTGKLYEFA 57
MADS cd00120
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 1-44 1.17e-24

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238067 [Multi-domain]  Cd Length: 59  Bit Score: 91.81  E-value: 1.17e-24
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 576236147   1 TNRQVTFCKRRNGLLKKAYELSVLCDAEVGLIVFSSRGRLYEYA 44
Cdd:cd00120   14 TSRQVTFSKRRNGLFKKASELSVLCDAEVAVIVFSPSGKLYEFW 57
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
1-43 3.81e-24

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 90.18  E-value: 3.81e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 576236147    1 TNRQVTFCKRRNGLLKKAYELSVLCDAEVGLIVFSSRGRLYEY 43
Cdd:pfam00319   6 RARQVTFSKRRKGLFKKASELSVLCGAEVAVIVFSPTGKLYTF 48
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 1-57 3.75e-20

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 80.77  E-value: 3.75e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 576236147   1 TNRQVTFCKRRNGLLKKAYELSVLCDAEVGLIVFSSRGRLYEYAN-NSVKATIERYKK 57
Cdd:cd00266   14 KKRAVTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPsSEVEGVISRFEV 71
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 1-98 1.06e-07

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 51.17  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576236147   1 TNRQVTFCKRRNGLLKKAYELSVLCDAEVGLIVFSSRGRLYEYannsvkaTIERYKKATSDSSTTGSVSE--INVQYYQQ 78
Cdd:COG5068   95 TKRSVTFSKRKHGINKKAFELSVLTGTEVLLLVISENGLVHTF-------TTPKLESVVKSLEGKSLIQSpcSNAPSDSS 167

                         90       100
                 ....*....|....*....|
gi 576236147  79 ESAKLRAQIGNLQNSNRHML 98
Cdd:COG5068  168 EEPSSSASFSVDPNDNNPMG 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH