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Conserved domains on  [gi|599127996|gb|AHN57544|]
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uncharacterized protein Dmel_CG6420, isoform B [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
298-417 7.11e-18

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.89  E-value: 7.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 298 DGYTILT-SKSKTTR-----NPLFKWVFSTDNCCVNEFCFSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCV 371
Cdd:COG2319  257 DGRLLASgSADGTVRlwdlaTGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 599127996 372 CWSPDGKYIVVGGEDDLVTVWSLHERRVVARGQGHRSWVSVVAFDP 417
Cdd:COG2319  337 AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
298-417 7.11e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.89  E-value: 7.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 298 DGYTILT-SKSKTTR-----NPLFKWVFSTDNCCVNEFCFSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCV 371
Cdd:COG2319  257 DGRLLASgSADGTVRlwdlaTGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 599127996 372 CWSPDGKYIVVGGEDDLVTVWSLHERRVVARGQGHRSWVSVVAFDP 417
Cdd:COG2319  337 AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 297-417 3.35e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 3.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 297 GDGYTILTSKSKTT------RNPLFKWVFSTDNCCVNEFCFSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLC 370
Cdd:cd00200  145 PDGTFVASSSQDGTiklwdlRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 599127996 371 VCWSPDGKYIVVGGEDDLVTVWSLHERRVVARGQGHRSWVSVVAFDP 417
Cdd:cd00200  225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 366-393 7.40e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 7.40e-04
                           10        20
                   ....*....|....*....|....*...
gi 599127996   366 GGFLCVCWSPDGKYIVVGGEDDLVTVWS 393
Cdd:smart00320  13 GPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
370-393 4.73e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 4.73e-03
                          10        20
                  ....*....|....*....|....
gi 599127996  370 CVCWSPDGKYIVVGGEDDLVTVWS 393
Cdd:pfam00400  16 SLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
298-417 7.11e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.89  E-value: 7.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 298 DGYTILT-SKSKTTR-----NPLFKWVFSTDNCCVNEFCFSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCV 371
Cdd:COG2319  257 DGRLLASgSADGTVRlwdlaTGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 599127996 372 CWSPDGKYIVVGGEDDLVTVWSLHERRVVARGQGHRSWVSVVAFDP 417
Cdd:COG2319  337 AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382
WD40 COG2319
WD40 repeat [General function prediction only];
326-518 1.49e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 1.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 326 VNEFCFSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCVCWSPDGKYIVVGGEDDLVTVWSLHERRVVARGQG 405
Cdd:COG2319  123 VRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 406 HRSWVSVVAFDP-----YTTSYTN----WDggdfSDDENQMNEYSHSRE----ARFSGDST--ANGGFEG----FDRNS- 465
Cdd:COG2319  203 HTGAVRSVAFSPdgkllASGSADGtvrlWD----LATGKLLRTLTGHSGsvrsVAFSPDGRllASGSADGtvrlWDLATg 278

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 599127996 466 ---TPVHADRNGPHSASFRSDASsaeklmsyRLGSVSQDTQICLWDITEDVLRHPL 518
Cdd:COG2319  279 ellRTLTGHSGGVNSVAFSPDGK--------LLASGSDDGTVRLWDLATGKLLRTL 326
WD40 COG2319
WD40 repeat [General function prediction only];
331-417 4.53e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 4.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 331 FSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCVCWSPDGKYIVVGGEDDLVTVWSLHERRVVARGQGHRSWV 410
Cdd:COG2319  254 FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333


                 ....*..
gi 599127996 411 SVVAFDP 417
Cdd:COG2319  334 RSVAFSP 340
WD40 COG2319
WD40 repeat [General function prediction only];
326-518 1.83e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 1.83e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 326 VNEFCFSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCVCWSPDGKYIVVGGEDDLVTVWSLHERRVVARGQG 405
Cdd:COG2319  165 VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 406 HRSWVSVVAFDP-----YTTSYTN----WDggdfSDDENQMNEYSHSREA----RFSGDST--ANGGFEG----FDRNST 466
Cdd:COG2319  245 HSGSVRSVAFSPdgrllASGSADGtvrlWD----LATGELLRTLTGHSGGvnsvAFSPDGKllASGSDDGtvrlWDLATG 320

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 599127996 467 PVHADRNGpHSASFRSDASSAEKLmsyRLGSVSQDTQICLWDITEDVLRHPL 518
Cdd:COG2319  321 KLLRTLTG-HTGAVRSVAFSPDGK---TLASGSDDGTVRLWDLATGELLRTL 368
WD40 COG2319
WD40 repeat [General function prediction only];
326-510 3.77e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.50  E-value: 3.77e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 326 VNEFCFSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCVCWSPDGKYIVVGGEDDLVTVWSLHERRVVARGQG 405
Cdd:COG2319  207 VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 406 HRSWVSVVAFDP-----YTTSYTN----WDGGDFSDDENQMNEYSHSREARFSGDST--ANGGFEG----FDRNSTPVHA 470
Cdd:COG2319  287 HSGGVNSVAFSPdgkllASGSDDGtvrlWDLATGKLLRTLTGHTGAVRSVAFSPDGKtlASGSDDGtvrlWDLATGELLR 366

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 599127996 471 DRNGP----HSASFRSDASsaeklmsyRLGSVSQDTQICLWDIT 510
Cdd:COG2319  367 TLTGHtgavTSVAFSPDGR--------TLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
331-518 2.13e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.18  E-value: 2.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 331 FSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCVCWSPDGKYIVVGGEDDLVTVWSLHERRVVARGQGHRSWV 410
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 411 SVVAFDP-----YTTSYTN----WDggdfSDDENQMNEYS-HSREAR---FSGDST--ANGGFEG----FDRNS----TP 467
Cdd:COG2319  166 TSVAFSPdgkllASGSDDGtvrlWD----LATGKLLRTLTgHTGAVRsvaFSPDGKllASGSADGtvrlWDLATgkllRT 241

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 599127996 468 VHADRNGPHSASFRSDASsaeklmsyRLGSVSQDTQICLWDITEDVLRHPL 518
Cdd:COG2319  242 LTGHSGSVRSVAFSPDGR--------LLASGSADGTVRLWDLATGELLRTL 284
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 297-417 3.35e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 3.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 297 GDGYTILTSKSKTT------RNPLFKWVFSTDNCCVNEFCFSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLC 370
Cdd:cd00200  145 PDGTFVASSSQDGTiklwdlRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 599127996 371 VCWSPDGKYIVVGGEDDLVTVWSLHERRVVARGQGHRSWVSVVAFDP 417
Cdd:cd00200  225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 326-417 1.03e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.59  E-value: 1.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 326 VNEFCFSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCVCWSPDGKYIVVGGEDDLVTVWSLHERRVVARGQG 405
Cdd:cd00200   12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTG 91

                         90
                 ....*....|..
gi 599127996 406 HRSWVSVVAFDP 417
Cdd:cd00200   92 HTSYVSSVAFSP 103
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 252-420 1.15e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 1.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 252 KVTCLKWLPNSPHLfLAAHASGHLYLYNeelpcaatapsyqpFKLGDGYTILTSKSKttrnplfkwvfstdncCVNEFCF 331
Cdd:cd00200   11 GVTCVAFSPDGKLL-ATGSGDGTIKVWD--------------LETGELLRTLKGHTG----------------PVRDVAA 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 332 SPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCVCWSPDGKYIVVGGEDDLVTVWSLHERRVVARGQGHRSWVS 411
Cdd:cd00200   60 SADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVN 139


                 ....*....
gi 599127996 412 VVAFDPYTT 420
Cdd:cd00200  140 SVAFSPDGT 148
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 253-393 8.27e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.73  E-value: 8.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 253 VTCLKWLPNSPHLFlAAHASGHLYLYN-EELPCAATAPSYQPF-----KLGDGYTILTSKSKTTrnpLFKWVFSTDNCC- 325
Cdd:cd00200  138 VNSVAFSPDGTFVA-SSSQDGTIKLWDlRTGKCVATLTGHTGEvnsvaFSPDGEKLLSSSSDGT---IKLWDLSTGKCLg 213

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 599127996 326 --------VNEFCFSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCVCWSPDGKYIVVGGEDDLVTVWS 393
Cdd:cd00200  214 tlrghengVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 357-421 1.99e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.57  E-value: 1.99e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 599127996 357 LLGIARSYFGGFLCVCWSPDGKYIVVGGEDDLVTVWSLHERRVVARGQGHRSWVSVVAFDPYTTS 421
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY 65
WD40 COG2319
WD40 repeat [General function prediction only];
331-417 1.75e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 1.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127996 331 FSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCVCWSPDGKYIVVGGEDDLVTVWSLHERRVVARGQGHRSWV 410
Cdd:COG2319   44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAV 123


                 ....*..
gi 599127996 411 SVVAFDP 417
Cdd:COG2319  124 RSVAFSP 130
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 366-393 7.40e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 7.40e-04
                           10        20
                   ....*....|....*....|....*...
gi 599127996   366 GGFLCVCWSPDGKYIVVGGEDDLVTVWS 393
Cdd:smart00320  13 GPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
370-393 4.73e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 4.73e-03
                          10        20
                  ....*....|....*....|....
gi 599127996  370 CVCWSPDGKYIVVGGEDDLVTVWS 393
Cdd:pfam00400  16 SLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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