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Conserved domains on  [gi|599131221|gb|AHN58042|]
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nudE, isoform F [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NUDE_C super family cl23541
NUDE protein, C-terminal conserved region; This family represents the C-terminal conserved ...
 129-292 3.66e-10

NUDE protein, C-terminal conserved region; This family represents the C-terminal conserved region of the NUDE proteins. NUDE proteins are involved in nuclear migration.


The actual alignment was detected with superfamily member pfam04880:

Pssm-ID: 461464 [Multi-domain]  Cd Length: 169  Bit Score: 57.88  E-value: 3.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221  129 SIENFEKMLDQAYEKNALLELEV----DEKGLLQEKLQRLMDETRDLKQELNVKSRftpvvngtsvptandtnTVNSSMN 204
Cdd:pfam04880   1 SLEDLESKYNQAIERGVLLEEEIkigeQERESLRIENQRLRDELSDLKQELAIRQE-----------------KLRNLLM 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221  205 SSASLPNGivANGELVKHDNAVATRATSVSVNalngslvnrneynqqhSLKNPENQINGNSMNPSSRTTALNIVADMLRK 284
Cdd:pfam04880  64 RSPSTPSL--QTLEIFDRSPAVQAVSSPVIAT----------------PPEKSFNSLRTGSETATPPSPPASESSDLLRK 125


                  ....*...
gi 599131221  285 LNAMETKL 292
Cdd:pfam04880 126 VGALTPKL 133
GAS super family cl25894
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 73-167 4.86e-05

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


The actual alignment was detected with superfamily member pfam13851:

Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 43.74  E-value: 4.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221   73 ENESLKLKLESHGIDMSNMEKQLETVKKDRDTMKVY---LRQLEQKNDDLERAHRILNESIENFEKMLDQAYEKNALLEL 149
Cdd:pfam13851  55 ENKRLTEPLQKAQEEVEELRKQLENYEKDKQSLKNLkarLKVLEKELKDLKWEHEVLEQRFEKVERERDELYDKFEAAIQ 134

                          90       100
                  ....*....|....*....|...
gi 599131221  150 EVDEKG-----LLQEKLQRLMDE 167
Cdd:pfam13851 135 DVQQKTglknlLLEKKLQALGET 157
 
Name Accession Description Interval E-value
NUDE_C pfam04880
NUDE protein, C-terminal conserved region; This family represents the C-terminal conserved ...
 129-292 3.66e-10

NUDE protein, C-terminal conserved region; This family represents the C-terminal conserved region of the NUDE proteins. NUDE proteins are involved in nuclear migration.


Pssm-ID: 461464 [Multi-domain]  Cd Length: 169  Bit Score: 57.88  E-value: 3.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221  129 SIENFEKMLDQAYEKNALLELEV----DEKGLLQEKLQRLMDETRDLKQELNVKSRftpvvngtsvptandtnTVNSSMN 204
Cdd:pfam04880   1 SLEDLESKYNQAIERGVLLEEEIkigeQERESLRIENQRLRDELSDLKQELAIRQE-----------------KLRNLLM 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221  205 SSASLPNGivANGELVKHDNAVATRATSVSVNalngslvnrneynqqhSLKNPENQINGNSMNPSSRTTALNIVADMLRK 284
Cdd:pfam04880  64 RSPSTPSL--QTLEIFDRSPAVQAVSSPVIAT----------------PPEKSFNSLRTGSETATPPSPPASESSDLLRK 125


                  ....*...
gi 599131221  285 LNAMETKL 292
Cdd:pfam04880 126 VGALTPKL 133
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 73-167 4.86e-05

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 43.74  E-value: 4.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221   73 ENESLKLKLESHGIDMSNMEKQLETVKKDRDTMKVY---LRQLEQKNDDLERAHRILNESIENFEKMLDQAYEKNALLEL 149
Cdd:pfam13851  55 ENKRLTEPLQKAQEEVEELRKQLENYEKDKQSLKNLkarLKVLEKELKDLKWEHEVLEQRFEKVERERDELYDKFEAAIQ 134

                          90       100
                  ....*....|....*....|...
gi 599131221  150 EVDEKG-----LLQEKLQRLMDE 167
Cdd:pfam13851 135 DVQQKTglknlLLEKKLQALGET 157
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 11-175 6.42e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 6.42e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221    11 EDECRYWKERSKQYHKEWTDVKQEYDEFVEQSREMEIEMDAT----------LDQKQSIIKDLTAKLTMFERENESLKLK 80
Cdd:TIGR02168  795 KEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATerrledleeqIEELSEDIESLAAEIEELEELIEELESE 874

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221    81 LESHGIDMSNMEKQLETVKKDRDTMKVYLRQLEQKNDDLERAHRILNESIENFEKMLDQAyeknallelevdeKGLLQEK 160
Cdd:TIGR02168  875 LEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGL-------------EVRIDNL 941

                          170
                   ....*....|....*
gi 599131221   161 LQRLMDETRDLKQEL 175
Cdd:TIGR02168  942 QERLSEEYSLTLEEA 956
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
12-180 8.87e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.05  E-value: 8.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221   12 DECRYWKERSKQYHKEwtdvkQEYDEFVEQSREMEIEMDATLDQkqsiIKDLTAKLTMFERENESLKLKLESH-GIDMSN 90
Cdd:COG4913   272 AELEYLRAALRLWFAQ-----RRLELLEAELEELRAELARLEAE----LERLEARLDALREELDELEAQIRGNgGDRLEQ 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221   91 MEKQLETVKKDRDTMKvylRQLEQKNDDLERAHRILNESIENFEKMLDQAyekNALLELEVDEKGLLQEKLQRLMDETRD 170
Cdd:COG4913   343 LEREIERLERELEERE---RRRARLEALLAALGLPLPASAEEFAALRAEA---AALLEALEEELEALEEALAEAEAALRD 416

                         170
                  ....*....|
gi 599131221  171 LKQELNVKSR 180
Cdd:COG4913   417 LRRELRELEA 426
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
18-183 3.18e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 39.28  E-value: 3.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221  18 KERSKQYHKEWTDVKQEYDEFVEQSREMEIEMDATLDQKQSIiKDLTAKLTMFERENESLKLKLESHGIDMSNMEKQLET 97
Cdd:PRK03918 192 EELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKEL-EELKEEIEELEKELESLEGSKRKLEEKIRELEERIEE 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221  98 VKKDRD--------------------TMKVYLRQLEQKNDDLERAHRILNESIENFEKMLDQAYEKNALL-ELEVDEKGL 156
Cdd:PRK03918 271 LKKEIEeleekvkelkelkekaeeyiKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLeELKKKLKEL 350

                        170       180       190
                 ....*....|....*....|....*....|...
gi 599131221 157 LQ-----EKLQRLMDETRDLKQELN-VKSRFTP 183
Cdd:PRK03918 351 EKrleelEERHELYEEAKAKKEELErLKKRLTG 383
 
Name Accession Description Interval E-value
NUDE_C pfam04880
NUDE protein, C-terminal conserved region; This family represents the C-terminal conserved ...
 129-292 3.66e-10

NUDE protein, C-terminal conserved region; This family represents the C-terminal conserved region of the NUDE proteins. NUDE proteins are involved in nuclear migration.


Pssm-ID: 461464 [Multi-domain]  Cd Length: 169  Bit Score: 57.88  E-value: 3.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221  129 SIENFEKMLDQAYEKNALLELEV----DEKGLLQEKLQRLMDETRDLKQELNVKSRftpvvngtsvptandtnTVNSSMN 204
Cdd:pfam04880   1 SLEDLESKYNQAIERGVLLEEEIkigeQERESLRIENQRLRDELSDLKQELAIRQE-----------------KLRNLLM 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221  205 SSASLPNGivANGELVKHDNAVATRATSVSVNalngslvnrneynqqhSLKNPENQINGNSMNPSSRTTALNIVADMLRK 284
Cdd:pfam04880  64 RSPSTPSL--QTLEIFDRSPAVQAVSSPVIAT----------------PPEKSFNSLRTGSETATPPSPPASESSDLLRK 125


                  ....*...
gi 599131221  285 LNAMETKL 292
Cdd:pfam04880 126 VGALTPKL 133
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 73-167 4.86e-05

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 43.74  E-value: 4.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221   73 ENESLKLKLESHGIDMSNMEKQLETVKKDRDTMKVY---LRQLEQKNDDLERAHRILNESIENFEKMLDQAYEKNALLEL 149
Cdd:pfam13851  55 ENKRLTEPLQKAQEEVEELRKQLENYEKDKQSLKNLkarLKVLEKELKDLKWEHEVLEQRFEKVERERDELYDKFEAAIQ 134

                          90       100
                  ....*....|....*....|...
gi 599131221  150 EVDEKG-----LLQEKLQRLMDE 167
Cdd:pfam13851 135 DVQQKTglknlLLEKKLQALGET 157
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 11-175 6.42e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 6.42e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221    11 EDECRYWKERSKQYHKEWTDVKQEYDEFVEQSREMEIEMDAT----------LDQKQSIIKDLTAKLTMFERENESLKLK 80
Cdd:TIGR02168  795 KEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATerrledleeqIEELSEDIESLAAEIEELEELIEELESE 874

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221    81 LESHGIDMSNMEKQLETVKKDRDTMKVYLRQLEQKNDDLERAHRILNESIENFEKMLDQAyeknallelevdeKGLLQEK 160
Cdd:TIGR02168  875 LEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGL-------------EVRIDNL 941

                          170
                   ....*....|....*
gi 599131221   161 LQRLMDETRDLKQEL 175
Cdd:TIGR02168  942 QERLSEEYSLTLEEA 956
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 33-186 1.78e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.51  E-value: 1.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221    33 QEYDEFVEQSREMEIEMDATLDQKQSIIKDLTAKLTMFERENESLKLKLESHGIDMSnmEKQLETVKKDRDTMKVYLRQL 112
Cdd:TIGR02168  375 EELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLE--EAELKELQAELEELEEELEEL 452

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 599131221   113 EQKNDDLERAHRILNESIENFEKMLDQAYEKNALLELEVDekgLLQEKLQRLMDETRDLKQELNVKSRFTPVVN 186
Cdd:TIGR02168  453 QEELERLEEALEELREELEEAEQALDAAERELAQLQARLD---SLERLQENLEGFSEGVKALLKNQSGLSGILG 523
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 11-176 2.11e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.12  E-value: 2.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221    11 EDECRYWKERSKQYHKEWTDVKQE---YDEFVEQSREMEIEMDATLDQKQSIIKDLTAKLTMFERENESLKLKLESHGID 87
Cdd:TIGR02168  739 EAEVEQLEERIAQLSKELTELEAEieeLEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEE 818

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221    88 MSNMEKQLETVKKDRDTMKVYLRQLEQKNDDLERAHRILNESIENFEKMLDQAYEKnalLELEVDEKGLLQEKLQRLMDE 167
Cdd:TIGR02168  819 AANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESE---LEALLNERASLEEALALLRSE 895


                   ....*....
gi 599131221   168 TRDLKQELN 176
Cdd:TIGR02168  896 LEELSEELR 904
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 9-142 3.39e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 42.36  E-value: 3.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221     9 SVEDECRYWKERSKQYHKEWTDVKQEYDEF-VEQSREME--IEMDATLDQKQSIIKDLTAKLTMFERENESLKLKLEShg 85
Cdd:TIGR02169  375 EVDKEFAETRDELKDYREKLEKLKREINELkRELDRLQEelQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKK-- 452

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 599131221    86 idmsnMEKQLETVKKDRDTMKVYLRQLEQKNDDLERAHRILNESIENFEKMLDQAYE 142
Cdd:TIGR02169  453 -----QEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEE 504
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
12-180 8.87e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.05  E-value: 8.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221   12 DECRYWKERSKQYHKEwtdvkQEYDEFVEQSREMEIEMDATLDQkqsiIKDLTAKLTMFERENESLKLKLESH-GIDMSN 90
Cdd:COG4913   272 AELEYLRAALRLWFAQ-----RRLELLEAELEELRAELARLEAE----LERLEARLDALREELDELEAQIRGNgGDRLEQ 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221   91 MEKQLETVKKDRDTMKvylRQLEQKNDDLERAHRILNESIENFEKMLDQAyekNALLELEVDEKGLLQEKLQRLMDETRD 170
Cdd:COG4913   343 LEREIERLERELEERE---RRRARLEALLAALGLPLPASAEEFAALRAEA---AALLEALEEELEALEEALAEAEAALRD 416

                         170
                  ....*....|
gi 599131221  171 LKQELNVKSR 180
Cdd:COG4913   417 LRRELRELEA 426
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 37-179 9.04e-04

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 40.56  E-value: 9.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221   37 EFVEQSREMEIEMDAT---LDQKQSIIKDLTAKLTMFERENESLK---LKLESHGIDMSNMEKQLETVKKDRDTMKVYLr 110
Cdd:pfam15905 174 EVMAKQEGMEGKLQVTqknLEHSKGKVAQLEEKLVSTEKEKIEEKsetEKLLEYITELSCVSEQVEKYKLDIAQLEELL- 252

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221  111 qlEQKNDDLERAHRILNESIENFEKMLDQAYEKNALLELEVDEK-GLLQEKLQRLMDETRDLKQELNVKS 179
Cdd:pfam15905 253 --KEKNDEIESLKQSLEEKEQELSKQIKDLNEKCKLLESEKEELlREYEEKEQTLNAELEELKEKLTLEE 320
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 65-179 9.35e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 9.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221    65 AKLTMFERENESLKL--KLESHGIDMSNMEKQLETVKKDRDTMKVYLRQLEQKNDDLERAHRILNESIENFEKMLDQAYE 142
Cdd:TIGR02168  668 TNSSILERRREIEELeeKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEE 747

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 599131221   143 KNALLELEVDEKGLLQEKLQRLMDETRDLKQELNVKS 179
Cdd:TIGR02168  748 RIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEI 784
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 33-180 1.33e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.43  E-value: 1.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221    33 QEYDEFVEQSREMEI--------EMDATLDQKQSIIKDLTAKLTMFERENESLKLKLESHGIDMSNMEKQLE-------T 97
Cdd:TIGR02168  213 ERYKELKAELRELELallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEelqkelyA 292

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221    98 VKKDRDTMKVYLRQLEQKNDDLERAHRILNESIENFEKMLDQAYEKNALLELEVDEKGLLQEKLQRLMDETRDLKQELNV 177
Cdd:TIGR02168  293 LANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELES 372


                   ...
gi 599131221   178 KSR 180
Cdd:TIGR02168  373 RLE 375
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 27-176 2.41e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.53  E-value: 2.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221  27 EWTDVKQEYDEFVEQSREMEIEMD---ATLDQKQSIIKDLTAKLTMFERENESLKLKLESHGIDMSNMEKQLETVKKDRD 103
Cdd:COG1196  233 KLRELEAELEELEAELEELEAELEeleAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRR 312

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 599131221 104 TMKVYLRQLEQKNDDLERAHRILNESIENFEKMLDQAYEKNALLELEVDEKGLLQEKLQRLMDETRDLKQELN 176
Cdd:COG1196  313 ELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELA 385
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
18-183 3.18e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 39.28  E-value: 3.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221  18 KERSKQYHKEWTDVKQEYDEFVEQSREMEIEMDATLDQKQSIiKDLTAKLTMFERENESLKLKLESHGIDMSNMEKQLET 97
Cdd:PRK03918 192 EELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKEL-EELKEEIEELEKELESLEGSKRKLEEKIRELEERIEE 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221  98 VKKDRD--------------------TMKVYLRQLEQKNDDLERAHRILNESIENFEKMLDQAYEKNALL-ELEVDEKGL 156
Cdd:PRK03918 271 LKKEIEeleekvkelkelkekaeeyiKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLeELKKKLKEL 350

                        170       180       190
                 ....*....|....*....|....*....|...
gi 599131221 157 LQ-----EKLQRLMDETRDLKQELN-VKSRFTP 183
Cdd:PRK03918 351 EKrleelEERHELYEEAKAKKEELErLKKRLTG 383
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
19-175 6.24e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 38.51  E-value: 6.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221  19 ERSKQYHKEWTDVKQEYDEFVEQSREME---IEMDATLDQKQSIIKDLTAKLTMFERENESL---KLKLESHGIDMSNME 92
Cdd:PRK03918 165 KNLGEVIKEIKRRIERLEKFIKRTENIEeliKEKEKELEEVLREINEISSELPELREELEKLekeVKELEELKEEIEELE 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599131221  93 KQLETVKKDRDTMKVYLRQLEqknddlerahrilnESIENFEKMLDQAYEKNALLElEVDEKGLLQEKLQRLMDETRDLK 172
Cdd:PRK03918 245 KELESLEGSKRKLEEKIRELE--------------ERIEELKKEIEELEEKVKELK-ELKEKAEEYIKLSEFYEEYLDEL 309


                 ...
gi 599131221 173 QEL 175
Cdd:PRK03918 310 REI 312
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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