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Conserved domains on  [gi|618841377|gb|AHX84171|]
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septin 7 variant 4 [Homo sapiens]

Protein Classification

septin family protein( domain architecture ID 10110922)

septin family protein, a filament-forming cytoskeletal GTPase, is involved in various cellular processes, including cytoskeleton organization, cytokinesis, and membrane dynamics

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CDC_Septin cd01850
CDC/Septin GTPase family; Septins are a conserved family of GTP-binding proteins associated ...
27-287 5.86e-161

CDC/Septin GTPase family; Septins are a conserved family of GTP-binding proteins associated with diverse processes in dividing and non-dividing cells. They were first discovered in the budding yeast S. cerevisiae as a set of genes (CDC3, CDC10, CDC11 and CDC12) required for normal bud morphology. Septins are also present in metazoan cells, where they are required for cytokinesis in some systems, and implicated in a variety of other processes involving organization of the cell cortex and exocytosis. In humans, 12 septin genes generate dozens of polypeptides, many of which comprise heterooligomeric complexes. Since septin mutants are commonly defective in cytokinesis and formation of the neck formation of the neck filaments/septin rings, septins have been considered to be the primary constituents of the neck filaments. Septins belong to the GTPase superfamily for their conserved GTPase motifs and enzymatic activities.


:

Pssm-ID: 206649  Cd Length: 275  Bit Score: 453.54  E-value: 5.86e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377  27 GESGLGKSTLINSLFLTDLYSPEYPG-PSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYID 105
Cdd:cd01850   11 GESGLGKSTFINTLFGTKLYPSKYPPaPGEHITKTVEIKISKAELEENGVKLKLTVIDTPGFGDNINNSDCWKPIVDYID 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377 106 SKFEDYLNAESRVNR-RQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKE 184
Cdd:cd01850   91 DQFESYLREESRINRnRRIPDTRVHCCLYFIPPTGHGLKPLDIEFMKKLSKKVNIIPVIAKADTLTPEELTEFKKRIMED 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377 185 IQEHKIKIYEFPETD-DEEENKLVKKIKDRLPLAVVGSNTIIEVNGKRVRGRQYPWGVAEVENGEHCDFTILRNMLIRTH 263
Cdd:cd01850  171 IEENNIKIYKFPEDEeDEEEIEENKKLKSLIPFAIVGSNEEVEVNGKKVRGRKYPWGVVEVENEEHCDFVKLRNLLIRTH 250
                        250       260
                 ....*....|....*....|....
gi 618841377 264 MQDLKDVTNNVHYENYRSRKLAAV 287
Cdd:cd01850  251 LQDLKETTHNVHYENYRSEKLEAL 274
PRK12704 super family cl36166
phosphodiesterase; Provisional
307-403 4.33e-04

phosphodiesterase; Provisional


The actual alignment was detected with superfamily member PRK12704:

Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.46  E-value: 4.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377 307 AQMEEERREHVAKMKKMEMEMEQVFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEaqhkELEEKRRQFEDEKANWEAQQR 386
Cdd:PRK12704  49 KEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLE----LLEKREEELEKKEKELEQKQQ 124
                         90
                 ....*....|....*..
gi 618841377 387 ILEQQNSsrTLEKNKKK 403
Cdd:PRK12704 125 ELEKKEE--ELEELIEE 139
 
Name Accession Description Interval E-value
CDC_Septin cd01850
CDC/Septin GTPase family; Septins are a conserved family of GTP-binding proteins associated ...
27-287 5.86e-161

CDC/Septin GTPase family; Septins are a conserved family of GTP-binding proteins associated with diverse processes in dividing and non-dividing cells. They were first discovered in the budding yeast S. cerevisiae as a set of genes (CDC3, CDC10, CDC11 and CDC12) required for normal bud morphology. Septins are also present in metazoan cells, where they are required for cytokinesis in some systems, and implicated in a variety of other processes involving organization of the cell cortex and exocytosis. In humans, 12 septin genes generate dozens of polypeptides, many of which comprise heterooligomeric complexes. Since septin mutants are commonly defective in cytokinesis and formation of the neck formation of the neck filaments/septin rings, septins have been considered to be the primary constituents of the neck filaments. Septins belong to the GTPase superfamily for their conserved GTPase motifs and enzymatic activities.


Pssm-ID: 206649  Cd Length: 275  Bit Score: 453.54  E-value: 5.86e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377  27 GESGLGKSTLINSLFLTDLYSPEYPG-PSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYID 105
Cdd:cd01850   11 GESGLGKSTFINTLFGTKLYPSKYPPaPGEHITKTVEIKISKAELEENGVKLKLTVIDTPGFGDNINNSDCWKPIVDYID 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377 106 SKFEDYLNAESRVNR-RQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKE 184
Cdd:cd01850   91 DQFESYLREESRINRnRRIPDTRVHCCLYFIPPTGHGLKPLDIEFMKKLSKKVNIIPVIAKADTLTPEELTEFKKRIMED 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377 185 IQEHKIKIYEFPETD-DEEENKLVKKIKDRLPLAVVGSNTIIEVNGKRVRGRQYPWGVAEVENGEHCDFTILRNMLIRTH 263
Cdd:cd01850  171 IEENNIKIYKFPEDEeDEEEIEENKKLKSLIPFAIVGSNEEVEVNGKKVRGRKYPWGVVEVENEEHCDFVKLRNLLIRTH 250
                        250       260
                 ....*....|....*....|....
gi 618841377 264 MQDLKDVTNNVHYENYRSRKLAAV 287
Cdd:cd01850  251 LQDLKETTHNVHYENYRSEKLEAL 274
Septin pfam00735
Septin; Members of this family include CDC3, CDC10, CDC11 and CDC12/Septin. Members of this ...
25-286 4.41e-155

Septin; Members of this family include CDC3, CDC10, CDC11 and CDC12/Septin. Members of this family bind GTP. As regards the septins, these are polypeptides of 30-65kDa with three characteriztic GTPase motifs (G-1, G-3 and G-4) that are similar to those of the Ras family. The G-4 motif is strictly conserved with a unique septin consensus of AKAD. Most septins are thought to have at least one coiled-coil region, which in some cases is necessary for intermolecular interactions that allow septins to polymerize to form rod-shaped complexes. In turn, these are arranged into tandem arrays to form filaments. They are multifunctional proteins, with roles in cytokinesis, sporulation, germ cell development, exocytosis and apoptosis.


Pssm-ID: 395596  Cd Length: 272  Bit Score: 438.27  E-value: 4.41e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377   25 ITGESGLGKSTLINSLFLTDLYSPE-YPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDY 103
Cdd:pfam00735   8 VVGESGLGKTTFINTLFLTDLYRARgIPGPSEKIKKTVEIKAYTVEIEEDGVKLNLTVIDTPGFGDAIDNSNCWRPIVEY 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377  104 IDSKFEDYLNAESRVNRRQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMK 183
Cdd:pfam00735  88 IDEQYEQYLRDESGLNRKSIKDNRVHCCLYFISPTGHGLKPLDVEFMKKLSEKVNIIPVIAKADTLTPDELQRFKKRIRE 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377  184 EIQEHKIKIYEFP--ETDDEEENKLVKKIKDRLPLAVVGSNTIIEVNGKRVRGRQYPWGVAEVENGEHCDFTILRNMLIR 261
Cdd:pfam00735 168 EIERQNIPIYHFPdeESDEDEEKELNEQLKSSIPFAIVGSNTVIENDGEKVRGRKYPWGVVEVENPSHCDFLKLRNMLIR 247
                         250       260
                  ....*....|....*....|....*
gi 618841377  262 THMQDLKDVTNNVHYENYRSRKLAA 286
Cdd:pfam00735 248 THLQDLKEVTHELHYETYRSEKLSA 272
CDC3 COG5019
Septin family protein [Cell cycle control, cell division, chromosome partitioning, ...
27-380 3.76e-128

Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 227352 [Multi-domain]  Cd Length: 373  Bit Score: 373.97  E-value: 3.76e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377  27 GESGLGKSTLINSLFLTDLYS--PEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYI 104
Cdd:COG5019   30 GESGLGKTTFINTLFGTSLVDetEIDDIRAEGTSPTLEIKITKAELEEDGFHLNLTVIDTPGFGDFIDNSKCWEPIVDYI 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377 105 DSKFEDYLNAESRVNR-RQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMK 183
Cdd:COG5019  110 DDQFDQYLDEEQKIKRnPKFKDTRVHACLYFIRPTGHGLKPLDIEAMKRLSKRVNLIPVIAKADTLTDDELAEFKERIRE 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377 184 EIQEHKIKIYE--FPETDDEEENKLVKKIKDRLPLAVVGSNTIIEVNGKRVRGRQYPWGVAEVENGEHCDFTILRNMLIR 261
Cdd:COG5019  190 DLEQYNIPVFDpyDPEDDEDESLEENQDLRSLIPFAIIGSNTEIENGGEQVRGRKYPWGVVEIDDEEHSDFKKLRNLLIR 269
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377 262 THMQDLKDVTNNVHYENYRSRKLAAvtyngvDNNKNKGQLTKSPLAQMEEERREhvakmkkmemeMEQVFEMKVKEKVQK 341
Cdd:COG5019  270 THLQELKETTENLLYENYRTEKLSG------LKNSGEPSLKEIHEARLNEEERE-----------LKKKFTEKIREKEKR 332
                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 618841377 342 LKDSEAELQRRHEQMKKNLEAQHKELEEKRRQFEDEKAN 380
Cdd:COG5019  333 LEELEQNLIEERKELNSKLEEIQKKLEDLEKRLEKLKSN 371
PRK12704 PRK12704
phosphodiesterase; Provisional
307-403 4.33e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.46  E-value: 4.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377 307 AQMEEERREHVAKMKKMEMEMEQVFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEaqhkELEEKRRQFEDEKANWEAQQR 386
Cdd:PRK12704  49 KEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLE----LLEKREEELEKKEKELEQKQQ 124
                         90
                 ....*....|....*..
gi 618841377 387 ILEQQNSsrTLEKNKKK 403
Cdd:PRK12704 125 ELEKKEE--ELEELIEE 139
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
334-406 1.22e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.58  E-value: 1.22e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 618841377 334 KVKEKVQKLKDSEAELQRRHEQMKKNLEAQHKELEEKRRQFEDEKANWEAQQRILEQQNSSRTLEKNKKKGKI 406
Cdd:COG3883  140 ADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAA 212
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
298-403 1.67e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 40.71  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377  298 KGQLTKSPLAQMEEERREHVAKMKKMEMEMEQ--VFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEAQ----HKEL---- 367
Cdd:pfam15709 393 KQRLEEERQRQEEEERKQRLQLQAAQERARQQqeEFRRKLQELQRKKQQEEAERAEAEKQRQKELEMQlaeeQKRLmema 472
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 618841377  368 EEKR------RQFEDEKANWEAQQRILEQQNSSRTLEKNKKK 403
Cdd:pfam15709 473 EEERleyqrqKQEAEEKARLEAEERRQKEEEAARLALEEAMK 514
uvrA PRK00349
excinuclease ABC subunit UvrA;
25-66 5.63e-03

excinuclease ABC subunit UvrA;


Pssm-ID: 234734 [Multi-domain]  Cd Length: 943  Bit Score: 38.90  E-value: 5.63e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 618841377  25 ITGESGLGKSTLINSLFLTDLY-----SPEYPGPSHRIK------KTVQVEQS 66
Cdd:PRK00349 640 VTGVSGSGKSTLINETLYKALArklngAKKVPGKHKEIEglehldKVIDIDQS 692
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
25-86 5.91e-03

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 37.35  E-value: 5.91e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 618841377   25 ITGESGLGKSTLINSLFLTDLYSPEYpgpshriKKTVQVEQSKVLIKEGGVQLLLTIVDTPG 86
Cdd:TIGR00231   6 IVGHPNVGKSTLLNSLLGNKGSITEY-------YPGTTRNYVTTVIEEDGKTYKFNLLDTAG 60
 
Name Accession Description Interval E-value
CDC_Septin cd01850
CDC/Septin GTPase family; Septins are a conserved family of GTP-binding proteins associated ...
27-287 5.86e-161

CDC/Septin GTPase family; Septins are a conserved family of GTP-binding proteins associated with diverse processes in dividing and non-dividing cells. They were first discovered in the budding yeast S. cerevisiae as a set of genes (CDC3, CDC10, CDC11 and CDC12) required for normal bud morphology. Septins are also present in metazoan cells, where they are required for cytokinesis in some systems, and implicated in a variety of other processes involving organization of the cell cortex and exocytosis. In humans, 12 septin genes generate dozens of polypeptides, many of which comprise heterooligomeric complexes. Since septin mutants are commonly defective in cytokinesis and formation of the neck formation of the neck filaments/septin rings, septins have been considered to be the primary constituents of the neck filaments. Septins belong to the GTPase superfamily for their conserved GTPase motifs and enzymatic activities.


Pssm-ID: 206649  Cd Length: 275  Bit Score: 453.54  E-value: 5.86e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377  27 GESGLGKSTLINSLFLTDLYSPEYPG-PSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYID 105
Cdd:cd01850   11 GESGLGKSTFINTLFGTKLYPSKYPPaPGEHITKTVEIKISKAELEENGVKLKLTVIDTPGFGDNINNSDCWKPIVDYID 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377 106 SKFEDYLNAESRVNR-RQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKE 184
Cdd:cd01850   91 DQFESYLREESRINRnRRIPDTRVHCCLYFIPPTGHGLKPLDIEFMKKLSKKVNIIPVIAKADTLTPEELTEFKKRIMED 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377 185 IQEHKIKIYEFPETD-DEEENKLVKKIKDRLPLAVVGSNTIIEVNGKRVRGRQYPWGVAEVENGEHCDFTILRNMLIRTH 263
Cdd:cd01850  171 IEENNIKIYKFPEDEeDEEEIEENKKLKSLIPFAIVGSNEEVEVNGKKVRGRKYPWGVVEVENEEHCDFVKLRNLLIRTH 250
                        250       260
                 ....*....|....*....|....
gi 618841377 264 MQDLKDVTNNVHYENYRSRKLAAV 287
Cdd:cd01850  251 LQDLKETTHNVHYENYRSEKLEAL 274
Septin pfam00735
Septin; Members of this family include CDC3, CDC10, CDC11 and CDC12/Septin. Members of this ...
25-286 4.41e-155

Septin; Members of this family include CDC3, CDC10, CDC11 and CDC12/Septin. Members of this family bind GTP. As regards the septins, these are polypeptides of 30-65kDa with three characteriztic GTPase motifs (G-1, G-3 and G-4) that are similar to those of the Ras family. The G-4 motif is strictly conserved with a unique septin consensus of AKAD. Most septins are thought to have at least one coiled-coil region, which in some cases is necessary for intermolecular interactions that allow septins to polymerize to form rod-shaped complexes. In turn, these are arranged into tandem arrays to form filaments. They are multifunctional proteins, with roles in cytokinesis, sporulation, germ cell development, exocytosis and apoptosis.


Pssm-ID: 395596  Cd Length: 272  Bit Score: 438.27  E-value: 4.41e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377   25 ITGESGLGKSTLINSLFLTDLYSPE-YPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDY 103
Cdd:pfam00735   8 VVGESGLGKTTFINTLFLTDLYRARgIPGPSEKIKKTVEIKAYTVEIEEDGVKLNLTVIDTPGFGDAIDNSNCWRPIVEY 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377  104 IDSKFEDYLNAESRVNRRQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMK 183
Cdd:pfam00735  88 IDEQYEQYLRDESGLNRKSIKDNRVHCCLYFISPTGHGLKPLDVEFMKKLSEKVNIIPVIAKADTLTPDELQRFKKRIRE 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377  184 EIQEHKIKIYEFP--ETDDEEENKLVKKIKDRLPLAVVGSNTIIEVNGKRVRGRQYPWGVAEVENGEHCDFTILRNMLIR 261
Cdd:pfam00735 168 EIERQNIPIYHFPdeESDEDEEKELNEQLKSSIPFAIVGSNTVIENDGEKVRGRKYPWGVVEVENPSHCDFLKLRNMLIR 247
                         250       260
                  ....*....|....*....|....*
gi 618841377  262 THMQDLKDVTNNVHYENYRSRKLAA 286
Cdd:pfam00735 248 THLQDLKEVTHELHYETYRSEKLSA 272
CDC3 COG5019
Septin family protein [Cell cycle control, cell division, chromosome partitioning, ...
27-380 3.76e-128

Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 227352 [Multi-domain]  Cd Length: 373  Bit Score: 373.97  E-value: 3.76e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377  27 GESGLGKSTLINSLFLTDLYS--PEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYI 104
Cdd:COG5019   30 GESGLGKTTFINTLFGTSLVDetEIDDIRAEGTSPTLEIKITKAELEEDGFHLNLTVIDTPGFGDFIDNSKCWEPIVDYI 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377 105 DSKFEDYLNAESRVNR-RQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMK 183
Cdd:COG5019  110 DDQFDQYLDEEQKIKRnPKFKDTRVHACLYFIRPTGHGLKPLDIEAMKRLSKRVNLIPVIAKADTLTDDELAEFKERIRE 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377 184 EIQEHKIKIYE--FPETDDEEENKLVKKIKDRLPLAVVGSNTIIEVNGKRVRGRQYPWGVAEVENGEHCDFTILRNMLIR 261
Cdd:COG5019  190 DLEQYNIPVFDpyDPEDDEDESLEENQDLRSLIPFAIIGSNTEIENGGEQVRGRKYPWGVVEIDDEEHSDFKKLRNLLIR 269
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377 262 THMQDLKDVTNNVHYENYRSRKLAAvtyngvDNNKNKGQLTKSPLAQMEEERREhvakmkkmemeMEQVFEMKVKEKVQK 341
Cdd:COG5019  270 THLQELKETTENLLYENYRTEKLSG------LKNSGEPSLKEIHEARLNEEERE-----------LKKKFTEKIREKEKR 332
                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 618841377 342 LKDSEAELQRRHEQMKKNLEAQHKELEEKRRQFEDEKAN 380
Cdd:COG5019  333 LEELEQNLIEERKELNSKLEEIQKKLEDLEKRLEKLKSN 371
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
25-210 7.67e-09

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 54.38  E-value: 7.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377  25 ITGESGLGKSTLINSLFLTdlyspEYPGPSHRIKKTVQVEQSKVLIKEGGVQllLTIVDTPGFGDAvdnsncwqpvidyi 104
Cdd:cd00882    2 VVGRGGVGKSSLLNALLGG-----EVGEVSDVPGTTRDPDVYVKELDKGKVK--LVLVDTPGLDEF-------------- 60
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377 105 dskfedylNAESRVNRRQMPDNRVQCCLYFIAPSGHGLKP--LDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIM 182
Cdd:cd00882   61 --------GGLGREELARLLLRGADLILLVVDSTDRESEEdaKLLILRRLRKEGIPIILVGNKIDLLEEREVEELLRLEE 132
                        170       180
                 ....*....|....*....|....*...
gi 618841377 183 KEiQEHKIKIYEFPETDDEEENKLVKKI 210
Cdd:cd00882  133 LA-KILGVPVFEVSAKTGEGVDELFEKL 159
YihA_EngB cd01876
YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli ...
27-197 6.62e-06

YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and consists of the GTPase domain only (some of the eukaryotic homologs contain an N-terminal extension of about 120 residues that might be involved in organellar targeting). Homologs of yihA are found in most Gram-positive and Gram-negative pathogenic bacteria, with the exception of Mycobacterium tuberculosis. The broad-spectrum nature of YihA and its essentiality for cell viability in bacteria make it an attractive antibacterial target.


Pssm-ID: 206665 [Multi-domain]  Cd Length: 170  Bit Score: 45.96  E-value: 6.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377  27 GESGLGKSTLINSLFltdlyspeypgpshRIKKTVQVeqSKvliKEGGVQLL--------LTIVDTPGFG-----DAVDN 93
Cdd:cd01876    6 GRSNVGKSSLINALT--------------NRKKLART--SK---TPGRTQLInffnvgdkFRLVDLPGYGyakvsKEVRE 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377  94 SncWQPVIdyidskfEDYLNaesrvNRRQMpdnrvqCCLYFIAPSGHGLKPLDIEFMKRL-HEKVNIIPLIAKADTLTPE 172
Cdd:cd01876   67 K--WGKLI-------EEYLE-----NRENL------KGVVLLIDARHGPTPIDLEMLEFLeELGIPFLIVLTKADKLKKS 126
                        170       180
                 ....*....|....*....|....*
gi 618841377 173 EcqqfKKQIMKEIQEHKIKIYEFPE 197
Cdd:cd01876  127 E----LAKVLKKIKEELNLFNILPP 147
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
25-214 1.60e-05

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 44.97  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377  25 ITGESGLGKSTLINSlFLTDLYSPEYPGPSHRikktVQVEQSKVLIKEGGVQLLltIVDTPGfgdavdnsncwQPVIDYI 104
Cdd:COG1100    8 VVGTGGVGKTSLVNR-LVGDIFSLEKYLSTNG----VTIDKKELKLDGLDVDLV--IWDTPG-----------QDEFRET 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377 105 DSKFEDYLNAESRV-----NRRqmPDNRVQccLYFIapsghglkpldIEFMKRLHEKVNIIPLIAKADtLTPEECQQFKK 179
Cdd:COG1100   70 RQFYARQLTGASLYlfvvdGTR--EETLQS--LYEL-----------LESLRRLGKKSPIILVLNKID-LYDEEEIEDEE 133
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 618841377 180 QIMKEIQEHKIK-IYEFPETDDEEENKLVKKIKDRL 214
Cdd:COG1100  134 RLKEALSEDNIVeVVATSAKTGEGVEELFAALAEIL 169
YeeP COG3596
Predicted GTPase [General function prediction only];
3-173 4.26e-04

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 42.06  E-value: 4.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377   3 PVANLELLGSSDPSALASQSAR-----------ITGESGLGKSTLINSLF-----LTDLYSPEypgpshrikkTVQVEQs 66
Cdd:COG3596   11 RLEALKRLPQVLRELLAEALERllvelpppviaLVGKTGAGKSSLINALFgaevaEVGVGRPC----------TREIQR- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377  67 kVLIKEGGVQlLLTIVDTPGFGDAVDNsncwqpviDYIDSKFEDYLNaESR----VNRRQMPDNRVqcclyfiapsghgl 142
Cdd:COG3596   80 -YRLESDGLP-GLVLLDTPGLGEVNER--------DREYRELRELLP-EADlilwVVKADDRALAT-------------- 134
                        170       180       190
                 ....*....|....*....|....*....|....
gi 618841377 143 kplDIEFMKRLHEKVNIIPLIA---KADTLTPEE 173
Cdd:COG3596  135 ---DEEFLQALRAQYPDPPVLVvltQVDRLEPER 165
PRK12704 PRK12704
phosphodiesterase; Provisional
307-403 4.33e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.46  E-value: 4.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377 307 AQMEEERREHVAKMKKMEMEMEQVFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEaqhkELEEKRRQFEDEKANWEAQQR 386
Cdd:PRK12704  49 KEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLE----LLEKREEELEKKEKELEQKQQ 124
                         90
                 ....*....|....*..
gi 618841377 387 ILEQQNSsrTLEKNKKK 403
Cdd:PRK12704 125 ELEKKEE--ELEELIEE 139
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
334-406 1.22e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.58  E-value: 1.22e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 618841377 334 KVKEKVQKLKDSEAELQRRHEQMKKNLEAQHKELEEKRRQFEDEKANWEAQQRILEQQNSSRTLEKNKKKGKI 406
Cdd:COG3883  140 ADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAA 212
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
27-92 1.65e-03

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 39.99  E-value: 1.65e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 618841377  27 GESGLGKSTLINSLF-----LTDLYSPEYPGPsHRIKKTVQveqskvlikegGVQllLTIVDTPGFGDAVD 92
Cdd:cd01853   38 GKTGVGKSSTINSIFgerkvSVSAFQSETLRP-REVSRTVD-----------GFK--LNIIDTPGLLESQD 94
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
298-403 1.67e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 40.71  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377  298 KGQLTKSPLAQMEEERREHVAKMKKMEMEMEQ--VFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEAQ----HKEL---- 367
Cdd:pfam15709 393 KQRLEEERQRQEEEERKQRLQLQAAQERARQQqeEFRRKLQELQRKKQQEEAERAEAEKQRQKELEMQlaeeQKRLmema 472
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 618841377  368 EEKR------RQFEDEKANWEAQQRILEQQNSSRTLEKNKKK 403
Cdd:pfam15709 473 EEERleyqrqKQEAEEKARLEAEERRQKEEEAARLALEEAMK 514
YjeQ_EngC cd01854
Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; ...
25-87 4.23e-03

Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain.


Pssm-ID: 206747 [Multi-domain]  Cd Length: 211  Bit Score: 38.15  E-value: 4.23e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 618841377  25 ITGESGLGKSTLINSLFltdlyspeyPGP-------SHRIKK----TVQVEqskvLIK--EGGVqllltIVDTPGF 87
Cdd:cd01854   90 LVGQSGVGKSTLLNALL---------PELvlatgeiSEKLGRgrhtTTHRE----LFPlpGGGL-----IIDTPGF 147
PTZ00121 PTZ00121
MAEBL; Provisional
292-403 4.53e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.35  E-value: 4.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377  292 VDNNKNKGQLTKSPLAQMEEERREHVAKMKKMEMEMEQVFEMKVKE-----KVQKLKDSEAELQRRHEQMKKNLEAQHKE 366
Cdd:PTZ00121 1652 LKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEaeeakKAEELKKKEAEEKKKAEELKKAEEENKIK 1731
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 618841377  367 LEEKRRQFEDEKANWEAQQRILEQQNSSRTLEKNKKK 403
Cdd:PTZ00121 1732 AEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEK 1768
uvrA PRK00349
excinuclease ABC subunit UvrA;
25-66 5.63e-03

excinuclease ABC subunit UvrA;


Pssm-ID: 234734 [Multi-domain]  Cd Length: 943  Bit Score: 38.90  E-value: 5.63e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 618841377  25 ITGESGLGKSTLINSLFLTDLY-----SPEYPGPSHRIK------KTVQVEQS 66
Cdd:PRK00349 640 VTGVSGSGKSTLINETLYKALArklngAKKVPGKHKEIEglehldKVIDIDQS 692
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
25-86 5.91e-03

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 37.35  E-value: 5.91e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 618841377   25 ITGESGLGKSTLINSLFLTDLYSPEYpgpshriKKTVQVEQSKVLIKEGGVQLLLTIVDTPG 86
Cdd:TIGR00231   6 IVGHPNVGKSTLLNSLLGNKGSITEY-------YPGTTRNYVTTVIEEDGKTYKFNLLDTAG 60
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
32-163 6.47e-03

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 36.06  E-value: 6.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 618841377   32 GKSTLINSLFLTDLYSPEYPGpshrikKTVQVEQSKVLIKEGGVQLlltiVDTPGFgdavdnsncwqpvidyIDSKFEDY 111
Cdd:pfam01926  11 GKSTLINALTGAKAIVSDYPG------TTRDPNEGRLELKGKQIIL----VDTPGL----------------IEGASEGE 64
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 618841377  112 LNAESRVNRRqmpdnRVQCCLYFIaPSGHGLKPLDIEFMKRLHEkvNIIPLI 163
Cdd:pfam01926  65 GLGRAFLAII-----EADLILFVV-DSEEGITPLDEELLELLRE--NKKPII 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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