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Conserved domains on  [gi|727863570|gb|AIY62392|]
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3-isopropylmalate dehydrogenase [synthetic construct]

Protein Classification

3-isopropylmalate dehydrogenase( domain architecture ID 10015518)

3-isopropylmalate dehydrogenase catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 5-367 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


:

Pssm-ID: 272939  Cd Length: 346  Bit Score: 572.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570    5 KIVVLPGDHIGPEIVASALEVLKVVEKkRPELKLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGGPEWTN- 83
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAE-RFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNl 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   84 -PNCRPEQGLLKLRKSMGVWANLRPCNFAsKSLVKYSPLKPEIVEGVDFCVVRELTGGCYFGERTEDNGSGYAMDTWPYS 162
Cdd:TIGR00169  80 pRDQRPEQGLLKLRKSLDLFANLRPAKVF-PGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGREGEGEAWDTEVYT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  163 LEEVSRIARLAAWLAETSNPpaPVTLLDKANVLATSRLWRKTVAKIFKeEYPHLTLKNQLIDSAAMLLVKSPRTLNgVVL 242
Cdd:TIGR00169 159 VPEIERIARVAFEMARKRRK--KVTSVDKANVLESSRLWRKTVEEIAK-EYPDVELEHQYIDNAAMQLVKSPTQFD-VVV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  243 TDNLFGDIISDEASVIPGSLGLLPSASLSgvvgkseEKVHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYGLNAPK 322
Cdd:TIGR00169 235 TSNLFGDILSDEASVITGSLGMLPSASLG-------SDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEE 307

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 727863570  323 EAEAIEAAVRKVLDDtsiggrGLYTRDLGGEASTADITKAVVEEL 367
Cdd:TIGR00169 308 AADAIEAAVKKVLAE------GYRTPDLGSSATTAVGTAEMGEEL 346
 
Name Accession Description Interval E-value
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 5-367 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 572.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570    5 KIVVLPGDHIGPEIVASALEVLKVVEKkRPELKLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGGPEWTN- 83
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAE-RFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNl 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   84 -PNCRPEQGLLKLRKSMGVWANLRPCNFAsKSLVKYSPLKPEIVEGVDFCVVRELTGGCYFGERTEDNGSGYAMDTWPYS 162
Cdd:TIGR00169  80 pRDQRPEQGLLKLRKSLDLFANLRPAKVF-PGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGREGEGEAWDTEVYT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  163 LEEVSRIARLAAWLAETSNPpaPVTLLDKANVLATSRLWRKTVAKIFKeEYPHLTLKNQLIDSAAMLLVKSPRTLNgVVL 242
Cdd:TIGR00169 159 VPEIERIARVAFEMARKRRK--KVTSVDKANVLESSRLWRKTVEEIAK-EYPDVELEHQYIDNAAMQLVKSPTQFD-VVV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  243 TDNLFGDIISDEASVIPGSLGLLPSASLSgvvgkseEKVHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYGLNAPK 322
Cdd:TIGR00169 235 TSNLFGDILSDEASVITGSLGMLPSASLG-------SDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEE 307

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 727863570  323 EAEAIEAAVRKVLDDtsiggrGLYTRDLGGEASTADITKAVVEEL 367
Cdd:TIGR00169 308 AADAIEAAVKKVLAE------GYRTPDLGSSATTAVGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
5-363 4.74e-178

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 497.97  E-value: 4.74e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570    5 KIVVLPGDHIGPEIVASALEVLKVVEKKRPeLKLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGGPEWTNP 84
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAP-LEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDPA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   85 NCRPEQGLLKLRKSMGVWANLRPCNFASkSLVKYSPLKPEiVEGVDFCVVRELTGGCYFGERTEDNGSG--YAMDTWPYS 162
Cdd:pfam00180  80 GVRPENGLLALRKELGLFANLRPAKVFP-PLGDASPLKNE-VEGVDIVIVRELTGGIYFGIEKGIKGSGneVAVDTKLYS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  163 LEEVSRIARLAAWLAEtSNPPAPVTLLDKANVLATSRLWRKTVAKIFKEEYPHLTLKNQLIDSAAMLLVKSPRtLNGVVL 242
Cdd:pfam00180 158 RDEIERIARVAFELAR-KRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPS-QFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  243 TDNLFGDIISDEASVIPGSLGLLPSASLSgvvgkseEKVHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYGLNAPK 322
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLG-------ANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLED 308

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 727863570  323 EAEAIEAAVRKVLDDtsiggrGLYTRDLGGEA---STADITKAV 363
Cdd:pfam00180 309 AADKIEAAVLKVLES------GIRTGDLAGSAtyvSTSEFGEAV 346
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 4-369 3.33e-174

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 488.84  E-value: 3.33e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   4 KKIVVLPGDHIGPEIVASALEVLKVVEKKRpELKLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGGPEWTN 83
Cdd:PRK00772   3 YKIAVLPGDGIGPEVMAEAVKVLDAVAEKF-GFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWDN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  84 --PNCRPEQGLLKLRKSMGVWANLRPCNFAsKSLVKYSPLKPEIVEGVDFCVVRELTGGCYFGE---RTEDNGSGYAMDT 158
Cdd:PRK00772  82 lpPDVRPERGLLALRKELGLFANLRPAKLY-PGLADASPLKPEIVAGLDILIVRELTGGIYFGEprgREGLGGEERAFDT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 159 WPYSLEEVSRIARLAAWLAETSNppAPVTLLDKANVLATSRLWRKTVAKIFKEeYPHLTLKNQLIDSAAMLLVKSPRTLn 238
Cdd:PRK00772 161 MVYTREEIERIARVAFELARKRR--KKVTSVDKANVLESSRLWREVVTEVAKE-YPDVELSHMYVDNAAMQLVRNPKQF- 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 239 GVVLTDNLFGDIISDEASVIPGSLGLLPSASLsGVVGKSeekvhcLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYGL 318
Cdd:PRK00772 237 DVIVTENLFGDILSDEAAMLTGSLGMLPSASL-GESGPG------LYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSL 309

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 727863570 319 NAPKEAEAIEAAVRKVLDDtsiggrGLYTRDL---GGEASTADITKAVVEELEK 369
Cdd:PRK00772 310 GLEEAADAIEAAVEKVLAQ------GYRTADIaegGGKVSTSEMGDAILAALAE 357
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 4-367 3.81e-156

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 442.53  E-value: 3.81e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   4 KKIVVLPGDHIGPEIVASALEVLKVVEKKRpELKLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGGPEWTn 83
Cdd:COG0473    2 YKIAVLPGDGIGPEVVAAALKVLEAAAERF-GLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWD- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  84 PNCRPEQGLLKLRKSMGVWANLRPCnfasKSL--VKySPLKPEIVEGVDFCVVRELTGGCYFGE---RTEDNGSGYAMDT 158
Cdd:COG0473   80 DGVRPESGLLALRKELDLYANLRPA----KLYpgLP-SPLKPEIVEGIDLVIVRENTEGLYFGIggrIGTGTGEEVAIDT 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 159 WPYSLEEVSRIARLAAWLAETSNPpaPVTLLDKANVLA-TSRLWRKTVAKIfKEEYPHLTLKNQLIDSAAMLLVKSPRTL 237
Cdd:COG0473  155 RVYTRKGIERIARYAFELARKRRK--KVTSVDKANVLKlTSGLWREVVREV-AKEYPDVELDHMYVDAAAMQLVRNPEQF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 238 NgVVLTDNLFGDIISDEASVIPGSLGLLPSASLSgvvgkseEKVHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYg 317
Cdd:COG0473  232 D-VIVTENLFGDILSDLAAGLTGSLGLAPSANIG-------DEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH- 302

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 727863570 318 LNAPKEAEAIEAAVRKVLDDtsiggrGLYTRDLGGEASTADITKAVVEEL 367
Cdd:COG0473  303 LGEEEAADAIEAAVEKVLAE------GVRTPDLGGKAGTSEMGDAIIAAL 346
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
4-370 2.18e-71

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 226.15  E-value: 2.18e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   4 KKIVVLPGDHIGPEIVASALEVLKVVEkkrpeLKLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGgpewTN 83
Cdd:NF040626   2 YKITVIPGDGIGKEVMEAALYVLDALD-----LNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVT----ST 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  84 PNCRpeQGLLKLRKSMGVWANLRPcnfaskslVKYSPLKPEIVEGVDFCVVRELTGGCYFG---ERTEDNGSGYAMDTWP 160
Cdd:NF040626  73 PGQK--SPIITLRKELDLYANLRP--------IKSYEGINCLFKDLDFLIVRENTEGLYSGleeEYTEEKAIAERVITRK 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 161 YSleevSRIARLAAWLAeTSNPPAPVTLLDKANVLA-TSRLWRKTVAKIfKEEYPHLTLKNQLIDSAAMLLVKSPRTLNg 239
Cdd:NF040626 143 AS----ERICKFAFEYA-IKLGRKKVTAVHKANVLKkTDGIFKDTFYKV-AKDYPQIETEDYYVDATAMYLITKPQDFD- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 240 VVLTDNLFGDIISDEASVIPGSLGLLPSASlsgvVGKSeekvHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYgLN 319
Cdd:NF040626 216 VIVTTNLFGDILSDEAAGLVGGLGLAPSAN----IGDK----NGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LG 286

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 727863570 320 APKEAEAIEAAVRKVLDDtsiggRGLYTRDLGGEASTADITKAVVEELEKI 370
Cdd:NF040626 287 ETYEANKLENALEKVLRE-----GKVVTPDLGGNAKTMEMANEIKKKIEEL 332
AksF_Meth NF040619
homoisocitrate dehydrogenase;
5-363 8.86e-60

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 196.13  E-value: 8.86e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   5 KIVVLPGDHIGPEIVASALEVLKVVEKkrpelkLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGGPEWTNP 84
Cdd:NF040619   3 KICVIEGDGIGKEVIPETVRVLKELGD------FEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKPTEL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  85 NCRPEQG-LLKLRKSMGVWANLRPC-NFASKSLVKysplkpeiveGVDFCVVRELTGGCYFGERTEDNGSGYAMDTWPYS 162
Cdd:NF040619  77 KNKNYKSpILTLRKELDLYANVRPInNFGDGQDVK----------NIDFVIIRENTEGLYVGREYYDEENEIAIAERIIS 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 163 LEEVSRIARLAAWLAETSNPPApVTLLDKANVL-ATSRLWRKTVAKIfKEEYPHLTLK--NQLIDSAAMLLVKSPRTLNg 239
Cdd:NF040619 147 KKGSERIIKFAFEYAKKNNRKK-VSCIHKANVLrVTDGLFLEIFNEI-KKKYKNFNIEadDYLVDATAMYLIKNPEMFD- 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 240 VVLTDNLFGDIISDEASVIPGSLGLLPSASLSGVVGkseekvhcLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYgLN 319
Cdd:NF040619 224 VIVTTNLFGDILSDEASGLIGGLGLAPSANIGDKKG--------LFEPVHGSAPDIAGKGIANPIATILSAAMMLDY-LG 294

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 727863570 320 APKEAEAIEAAVRKVLDdtsiggRGLYTRDLGGEASTADITKAV 363
Cdd:NF040619 295 MKEKGDLIREAVKKCLE------NGKVTPDLGGNLKTKEVTDKI 332
 
Name Accession Description Interval E-value
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 5-367 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 572.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570    5 KIVVLPGDHIGPEIVASALEVLKVVEKkRPELKLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGGPEWTN- 83
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAE-RFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNl 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   84 -PNCRPEQGLLKLRKSMGVWANLRPCNFAsKSLVKYSPLKPEIVEGVDFCVVRELTGGCYFGERTEDNGSGYAMDTWPYS 162
Cdd:TIGR00169  80 pRDQRPEQGLLKLRKSLDLFANLRPAKVF-PGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGREGEGEAWDTEVYT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  163 LEEVSRIARLAAWLAETSNPpaPVTLLDKANVLATSRLWRKTVAKIFKeEYPHLTLKNQLIDSAAMLLVKSPRTLNgVVL 242
Cdd:TIGR00169 159 VPEIERIARVAFEMARKRRK--KVTSVDKANVLESSRLWRKTVEEIAK-EYPDVELEHQYIDNAAMQLVKSPTQFD-VVV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  243 TDNLFGDIISDEASVIPGSLGLLPSASLSgvvgkseEKVHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYGLNAPK 322
Cdd:TIGR00169 235 TSNLFGDILSDEASVITGSLGMLPSASLG-------SDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEE 307

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 727863570  323 EAEAIEAAVRKVLDDtsiggrGLYTRDLGGEASTADITKAVVEEL 367
Cdd:TIGR00169 308 AADAIEAAVKKVLAE------GYRTPDLGSSATTAVGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
5-363 4.74e-178

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 497.97  E-value: 4.74e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570    5 KIVVLPGDHIGPEIVASALEVLKVVEKKRPeLKLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGGPEWTNP 84
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAP-LEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDPA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   85 NCRPEQGLLKLRKSMGVWANLRPCNFASkSLVKYSPLKPEiVEGVDFCVVRELTGGCYFGERTEDNGSG--YAMDTWPYS 162
Cdd:pfam00180  80 GVRPENGLLALRKELGLFANLRPAKVFP-PLGDASPLKNE-VEGVDIVIVRELTGGIYFGIEKGIKGSGneVAVDTKLYS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  163 LEEVSRIARLAAWLAEtSNPPAPVTLLDKANVLATSRLWRKTVAKIFKEEYPHLTLKNQLIDSAAMLLVKSPRtLNGVVL 242
Cdd:pfam00180 158 RDEIERIARVAFELAR-KRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPS-QFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  243 TDNLFGDIISDEASVIPGSLGLLPSASLSgvvgkseEKVHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYGLNAPK 322
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLG-------ANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLED 308

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 727863570  323 EAEAIEAAVRKVLDDtsiggrGLYTRDLGGEA---STADITKAV 363
Cdd:pfam00180 309 AADKIEAAVLKVLES------GIRTGDLAGSAtyvSTSEFGEAV 346
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 4-369 3.33e-174

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 488.84  E-value: 3.33e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   4 KKIVVLPGDHIGPEIVASALEVLKVVEKKRpELKLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGGPEWTN 83
Cdd:PRK00772   3 YKIAVLPGDGIGPEVMAEAVKVLDAVAEKF-GFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWDN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  84 --PNCRPEQGLLKLRKSMGVWANLRPCNFAsKSLVKYSPLKPEIVEGVDFCVVRELTGGCYFGE---RTEDNGSGYAMDT 158
Cdd:PRK00772  82 lpPDVRPERGLLALRKELGLFANLRPAKLY-PGLADASPLKPEIVAGLDILIVRELTGGIYFGEprgREGLGGEERAFDT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 159 WPYSLEEVSRIARLAAWLAETSNppAPVTLLDKANVLATSRLWRKTVAKIFKEeYPHLTLKNQLIDSAAMLLVKSPRTLn 238
Cdd:PRK00772 161 MVYTREEIERIARVAFELARKRR--KKVTSVDKANVLESSRLWREVVTEVAKE-YPDVELSHMYVDNAAMQLVRNPKQF- 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 239 GVVLTDNLFGDIISDEASVIPGSLGLLPSASLsGVVGKSeekvhcLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYGL 318
Cdd:PRK00772 237 DVIVTENLFGDILSDEAAMLTGSLGMLPSASL-GESGPG------LYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSL 309

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 727863570 319 NAPKEAEAIEAAVRKVLDDtsiggrGLYTRDL---GGEASTADITKAVVEELEK 369
Cdd:PRK00772 310 GLEEAADAIEAAVEKVLAQ------GYRTADIaegGGKVSTSEMGDAILAALAE 357
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 4-367 3.81e-156

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 442.53  E-value: 3.81e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   4 KKIVVLPGDHIGPEIVASALEVLKVVEKKRpELKLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGGPEWTn 83
Cdd:COG0473    2 YKIAVLPGDGIGPEVVAAALKVLEAAAERF-GLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWD- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  84 PNCRPEQGLLKLRKSMGVWANLRPCnfasKSL--VKySPLKPEIVEGVDFCVVRELTGGCYFGE---RTEDNGSGYAMDT 158
Cdd:COG0473   80 DGVRPESGLLALRKELDLYANLRPA----KLYpgLP-SPLKPEIVEGIDLVIVRENTEGLYFGIggrIGTGTGEEVAIDT 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 159 WPYSLEEVSRIARLAAWLAETSNPpaPVTLLDKANVLA-TSRLWRKTVAKIfKEEYPHLTLKNQLIDSAAMLLVKSPRTL 237
Cdd:COG0473  155 RVYTRKGIERIARYAFELARKRRK--KVTSVDKANVLKlTSGLWREVVREV-AKEYPDVELDHMYVDAAAMQLVRNPEQF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 238 NgVVLTDNLFGDIISDEASVIPGSLGLLPSASLSgvvgkseEKVHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYg 317
Cdd:COG0473  232 D-VIVTENLFGDILSDLAAGLTGSLGLAPSANIG-------DEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH- 302

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 727863570 318 LNAPKEAEAIEAAVRKVLDDtsiggrGLYTRDLGGEASTADITKAVVEEL 367
Cdd:COG0473  303 LGEEEAADAIEAAVEKVLAE------GVRTPDLGGKAGTSEMGDAIIAAL 346
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 6-336 2.87e-82

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 256.54  E-value: 2.87e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   6 IVVLPGDHIGPEIVASALEVLKVVEKKRpELKLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGGPEW--TN 83
Cdd:PLN02329  49 IALLPGDGIGPEVISVAKNVLQKAGSLE-GLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWdkNE 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  84 PNCRPEQGLLKLRKSMGVWANLRPCNFASKsLVKYSPLKPEIVEGVDFCVVRELTGGCYFGE----RTEDNGSGYAMDTW 159
Cdd:PLN02329 128 KHLRPEMALFYLRRDLKVFANLRPATVLPQ-LVDASTLKKEVAEGVDMMIVRELTGGIYFGEprgiTINENGEEVGVSTE 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 160 PYSLEEVSRIARLAAWLAETSNppAPVTLLDKANVLATSRLWRKTVAKIfKEEYPHLTLKNQLIDSAAMLLVKSPRTLNG 239
Cdd:PLN02329 207 IYAAHEIDRIARVAFETARKRR--GKLCSVDKANVLDASILWRKRVTAL-ASEYPDVELSHMYVDNAAMQLIRDPKQFDT 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 240 VVlTDNLFGDIISDEASVIPGSLGLLPSASLsGVVGKSeekvhcLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYGLN 319
Cdd:PLN02329 284 IV-TNNIFGDILSDEASMITGSIGMLPSASL-GESGPG------LFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLG 355

                        330
                 ....*....|....*..
gi 727863570 320 APKEAEAIEAAVRKVLD 336
Cdd:PLN02329 356 EEKAAKRIEDAVVDALN 372
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 3-367 3.25e-73

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 230.79  E-value: 3.25e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   3 AKKIVVLPGDHIGPEIVASALEVLKVVEkkrpeLKLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGGPewt 82
Cdd:PRK14025   1 MHKICVIEGDGIGKEVVPAALHVLEATG-----LPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAGET--- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  83 npncrPEQGLLKLRKSMGVWANLRPcnfaSKSLVKYSPLKPeiveGVDFCVVRELTGGCYFGERtEDNGSGYAMDTWPYS 162
Cdd:PRK14025  73 -----AADVIVKLRRILDTYANVRP----VKSYKGVKCLYP----DIDYVIVRENTEGLYKGIE-AEIADGVTVATRVIT 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 163 LEEVSRIARLAAWLAETSNPPA---PVTLLDKANVLA-TSRLWRKTVAKIFKEeYPHLTLKNQLIDSAAMLLVKSPRTLN 238
Cdd:PRK14025 139 RKASERIFRFAFEMAKRRKKMGkegKVTCAHKANVLKkTDGLFKKTFYEVAKE-YPDIKAEDYYVDAMNMYIITRPQTFD 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 239 gVVLTDNLFGDIISDEASVIPGSLGLLPSASlsgvVGKSeekvHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYgL 318
Cdd:PRK14025 218 -VVVTSNLFGDILSDGAAGLVGGLGLAPSAN----IGDK----YGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRH-L 287

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 727863570 319 NAPKEAEAIEAAVRKVLDdtsiggRGLYTRDLGGEASTADITKAVVEEL 367
Cdd:PRK14025 288 GENEEADKVEKALEEVLA------LGLTTPDLGGNLSTMEMAEEVAKRV 330
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
4-370 2.18e-71

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 226.15  E-value: 2.18e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   4 KKIVVLPGDHIGPEIVASALEVLKVVEkkrpeLKLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGgpewTN 83
Cdd:NF040626   2 YKITVIPGDGIGKEVMEAALYVLDALD-----LNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVT----ST 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  84 PNCRpeQGLLKLRKSMGVWANLRPcnfaskslVKYSPLKPEIVEGVDFCVVRELTGGCYFG---ERTEDNGSGYAMDTWP 160
Cdd:NF040626  73 PGQK--SPIITLRKELDLYANLRP--------IKSYEGINCLFKDLDFLIVRENTEGLYSGleeEYTEEKAIAERVITRK 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 161 YSleevSRIARLAAWLAeTSNPPAPVTLLDKANVLA-TSRLWRKTVAKIfKEEYPHLTLKNQLIDSAAMLLVKSPRTLNg 239
Cdd:NF040626 143 AS----ERICKFAFEYA-IKLGRKKVTAVHKANVLKkTDGIFKDTFYKV-AKDYPQIETEDYYVDATAMYLITKPQDFD- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 240 VVLTDNLFGDIISDEASVIPGSLGLLPSASlsgvVGKSeekvHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYgLN 319
Cdd:NF040626 216 VIVTTNLFGDILSDEAAGLVGGLGLAPSAN----IGDK----NGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LG 286

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 727863570 320 APKEAEAIEAAVRKVLDDtsiggRGLYTRDLGGEASTADITKAVVEELEKI 370
Cdd:NF040626 287 ETYEANKLENALEKVLRE-----GKVVTPDLGGNAKTMEMANEIKKKIEEL 332
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 5-367 2.36e-64

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 208.24  E-value: 2.36e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   5 KIVVLPGDHIGPEIVASALEVLKVVEKKRPelKLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGGPewTNP 84
Cdd:PRK03437   6 KLAVIPGDGIGPEVVAEALKVLDAVAAGGP--GVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGDP--SVP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  85 NCRPEQG-LLKLRKSMGVWANLRPcnfaskslVK-----YSPLK--PEIvegvDFCVVRELTGGCYFGertedNGSGYAM 156
Cdd:PRK03437  82 SGVLERGlLLKLRFALDHYVNLRP--------SKlypgvTSPLAgpGDI----DFVVVREGTEGPYTG-----NGGALRV 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 157 DTwPYSLE-EVS--------RIARLAAWLAEtSNPPAPVTLLDKANVLATS-RLWRKTVAKIfKEEYPHLTLKNQLIDSA 226
Cdd:PRK03437 145 GT-PHEVAtEVSvntafgveRVVRDAFERAQ-KRPRKHLTLVHKTNVLTFAgDLWQRTVDEV-AAEYPDVTVDYQHVDAA 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 227 AMLLVKSPRTLNgVVLTDNLFGDIISDEASVIPGSLGLLPSASLSGV-VGKSeekvhcLVEPIHGSAPDIAGKGIVNPVG 305
Cdd:PRK03437 222 TIFMVTDPSRFD-VIVTDNLFGDIITDLAAAVTGGIGLAASGNINPTgTNPS------MFEPVHGSAPDIAGQGIADPTA 294

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727863570 306 TILSASLLLRYgLNAPKEAEAIEAAVRKVLddtsiGGRGlytrdlGGEASTADITKAVVEEL 367
Cdd:PRK03437 295 AILSVALLLDH-LGEEDAAARIEAAVEADL-----AERG------KMGRSTAEVGDRIAARL 344
AksF_Meth NF040619
homoisocitrate dehydrogenase;
5-363 8.86e-60

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 196.13  E-value: 8.86e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   5 KIVVLPGDHIGPEIVASALEVLKVVEKkrpelkLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGGPEWTNP 84
Cdd:NF040619   3 KICVIEGDGIGKEVIPETVRVLKELGD------FEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKPTEL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  85 NCRPEQG-LLKLRKSMGVWANLRPC-NFASKSLVKysplkpeiveGVDFCVVRELTGGCYFGERTEDNGSGYAMDTWPYS 162
Cdd:NF040619  77 KNKNYKSpILTLRKELDLYANVRPInNFGDGQDVK----------NIDFVIIRENTEGLYVGREYYDEENEIAIAERIIS 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 163 LEEVSRIARLAAWLAETSNPPApVTLLDKANVL-ATSRLWRKTVAKIfKEEYPHLTLK--NQLIDSAAMLLVKSPRTLNg 239
Cdd:NF040619 147 KKGSERIIKFAFEYAKKNNRKK-VSCIHKANVLrVTDGLFLEIFNEI-KKKYKNFNIEadDYLVDATAMYLIKNPEMFD- 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 240 VVLTDNLFGDIISDEASVIPGSLGLLPSASLSGVVGkseekvhcLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYgLN 319
Cdd:NF040619 224 VIVTTNLFGDILSDEASGLIGGLGLAPSANIGDKKG--------LFEPVHGSAPDIAGKGIANPIATILSAAMMLDY-LG 294

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 727863570 320 APKEAEAIEAAVRKVLDdtsiggRGLYTRDLGGEASTADITKAV 363
Cdd:NF040619 295 MKEKGDLIREAVKKCLE------NGKVTPDLGGNLKTKEVTDKI 332
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 5-367 3.25e-59

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 195.44  E-value: 3.25e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570    5 KIVVLPGDHIGPEIVASALEVLKVVEKKRPELKLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGGPEWTNP 84
Cdd:TIGR02089   5 RIAAIPGDGIGKEVVAAALQVLEAAAKRHGGFSLHFTEFPWSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPALVPD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   85 NCRPEQGLLKLRKSMGVWANLRPCNFASKslVKySPLKPEIVEGVDFCVVRELTGGCYF---GERTEDNGSGYAMDTWPY 161
Cdd:TIGR02089  85 HISLWGLLLKIRREFDQYANVRPAKLLPG--VT-SPLRNCGPGDFDFVVVRENSEGEYSgvgGRIHRGTDEEVATQNAIF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  162 SLEEVSRIARLAAWLAETSNppAPVTLLDKANVLATSRLWRKTVAKIFKEEYPHLTLKNQLIDSAAMLLVKSPRTLNgVV 241
Cdd:TIGR02089 162 TRKGVERIMRFAFELAQKRR--KHLTSATKSNGIRHSMPFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPETFD-VI 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  242 LTDNLFGDIISDEASVIPGSLGLLPSASLSgvvgkSEEKVHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYgLNAP 321
Cdd:TIGR02089 239 VASNLFGDILSDLGAALMGSLGVAPSANIN-----PEGKFPSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEH-LGEK 312

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 727863570  322 KEAEAIEAAVRKVLddtsigGRGLYTRDLGGEASTADITKAVVEEL 367
Cdd:TIGR02089 313 EAGAKIMDAIERVT------AAGILTPDVGGKATTSEVTEAVCNAL 352
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 4-367 4.43e-53

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 178.76  E-value: 4.43e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   4 KKIVVLPGDHIGPEIVASALEVLKVVEkkrpeLKLEFEEHKIGGASIDAYGTPLTDETVKAcLEADGVLLGA-----VGG 78
Cdd:PRK08997   3 QTITVIPGDGIGPSIIDATLKILDKLG-----CDFEYEFADAGLTALEKHGELLPQRTLDL-IEKNKIALKGplttpVGE 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  79 pEWTNPNcrpeqglLKLRKSMGVWANLRPcnfaskslVKYSPLKPEIVEGVDFCVVRELTGGCYFGE---RTEDNGSGYA 155
Cdd:PRK08997  77 -GFTSIN-------VTLRKKFDLYANVRP--------VLSFPGTKARYDNIDIITVRENTEGMYSGEgqtVSEDGETAEA 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 156 MDTwpYSLEEVSRIARLAAWLAETSNPPApVTLLDKANVL-ATSRLWRKtVAKIFKEEYPHLTLKNQLIDSAAMLLVKSP 234
Cdd:PRK08997 141 TSI--ITRKGAERIVRFAYELARKEGRKK-VTAVHKANIMkSTSGLFLK-VAREVALRYPDIEFEEMIVDATCMQLVMNP 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 235 RTLNgVVLTDNLFGDIISDEASVIPGSLGLLPSASlsgvVGKSEekvhCLVEPIHGSAPDIAGKGIVNPVGTILSASLLL 314
Cdd:PRK08997 217 EQFD-VIVTTNLFGDILSDLCAGLVGGLGMAPGAN----IGRDA----AIFEAVHGSAPDIAGKNLANPTSVILAAIQML 287

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 727863570 315 RYgLNAPKEAEAIEAAVRKVLDDtsiGGRglYTRDLGGEASTADITKAVVEEL 367
Cdd:PRK08997 288 EY-LGMPDKAERIRKAIVAVIEA---GDR--TTRDLGGTHGTTDFTQAVIDRL 334
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 5-370 1.86e-52

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 177.61  E-value: 1.86e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   5 KIVVLPGDHIGPEIVASALEVLKVVEKKRPELKLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGgpewtNP 84
Cdd:PRK08194   5 KIAVIPGDGVGKEVVPAAVRVLKAVAEVHGGLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVG-----NP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  85 NCRPEQ----GLL-KLRKSMGVWANLRPcnfaskslVKY-----SPLKPEivEGVDFCVVRELTGGCY--FGERTEDNGS 152
Cdd:PRK08194  80 KLVPDHislwGLLiKIRREFEQVINIRP--------AKQlrgikSPLANP--KDFDLLVVRENSEGEYseVGGRIHRGED 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 153 GYAMDTWPYSLEEVSRIARLAAWLAETsnPPAPVTLLDKANVLATSRLWRKTVAKIFKEEYPHLTLKNQLIDSAAMLLVK 232
Cdd:PRK08194 150 EIAIQNAVFTRKGTERAMRYAFELAAK--RRKHVTSATKSNGIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAFFVT 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 233 SPRTLNgVVLTDNLFGDIISDEASVIPGSLGLLPSASLSgVVGKSEEkvhcLVEPIHGSAPDIAGKGIVNPVGTILSASL 312
Cdd:PRK08194 228 RPEEFD-VIVASNLFGDILTDIGAAIMGSIGIAPAANIN-VNGKYPS----MFEPVHGSAPDIAGKGIANPIGQIWTAKL 301

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 727863570 313 LL-RYGlnapkEAEAiEAAVRKVLDDTSigGRGLYTRDLGGEASTADITKAVVEELEKI 370
Cdd:PRK08194 302 MLdHFG-----EEEL-GSHLLDVIEDVT--EDGIKTPDIGGRATTDEVTDEIISRLKKL 352
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 8-367 4.36e-44

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 156.19  E-value: 4.36e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   8 VLPGDHIGPEIVASALEVLKVVEkkrpeLKLEFEEHKIGGASIDAYGTPLTDETVkacleaDGVLLGAVG--GPEWTnPN 85
Cdd:PLN00118  46 LFPGDGIGPEIAESVKQVFTAAG-----VPIEWEEHYVGTTVDPRTGSFLTWESL------ESVRRNKVGlkGPMAT-PI 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  86 CRPEQGL-LKLRKSMGVWANLRPCNFASKSLVKYsplkpeivEGVDFCVVRELTGGCYfgertedngSGYAMDTWPYSLE 164
Cdd:PLN00118 114 GKGHRSLnLTLRKELGLYANVRPCYSLPGYKTRY--------DDVDLVTIRENTEGEY---------SGLEHQVVRGVVE 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 165 EVSRIARLA-------AWLAETSNPPAPVTLLDKANVL-ATSRLWRKTVAKIfKEEYPHLTLKNQLIDSAAMLLVKSPrT 236
Cdd:PLN00118 177 SLKIITRQAslrvaeyAFHYAKTHGRKRVSAIHKANIMkKTDGLFLKCCREV-AEKYPEIVYEEVIIDNCCMMLVKNP-A 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 237 LNGVVLTDNLFGDIISDEASVIPGSLGLLPSASLSgvvgkseEKVHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRY 316
Cdd:PLN00118 255 LFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIG-------ENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRH 327

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 727863570 317 gLNAPKEAEAIEAAVRKVLDDtsiggrGLY-TRDLGGEASTADITKAVVEEL 367
Cdd:PLN00118 328 -LKLNEQAEQIHNAILNTIAE------GKYrTADLGGSSTTTDFTKAICDHL 372
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
4-369 8.61e-43

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 155.05  E-value: 8.61e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   4 KKIVVLPGDHIGPEIVASALEVLKVVEKKrpelkLEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAvggpewtn 83
Cdd:PRK09222   5 TPITVAYGDGIGPEIMEAVLKILEAAGAP-----LEIETIEIGEKVYKKGWTSGISPSAWESIRRTKVLLKA-------- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  84 PNCRPEQGLLK-----LRKSMGVWANLRPCnfaskslVKYSPLKPEIVEGVDFCVVRELTGGCYFG---ERTEDNGSGYA 155
Cdd:PRK09222  72 PITTPQGGGYKslnvtLRKTLGLYANVRPC-------VSYHPFVETKHPNLDVVIIRENEEDLYAGiehRQTPDVYQCLK 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 156 MDTWPYSleevSRIARLAAWLAETSNPpAPVTLLDKANVLA-TSRLWRKTVAKIFKEeYPHLTLKNQLIDSAAMLLVKSP 234
Cdd:PRK09222 145 LISRPGS----EKIIRYAFEYARANGR-KKVTCLTKDNIMKlTDGLFHKVFDEIAKE-YPDIEAEHYIVDIGAARLATNP 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 235 RTLNgVVLTDNLFGDIISDEASVIPGSLGLLPSASlsgvVGKseekvHC-LVEPIHGSAPDIAGKGIVNPVGTILSASLL 313
Cdd:PRK09222 219 ENFD-VIVTPNLYGDILSDIAAEISGSVGLAGSAN----IGE-----EYaMFEAVHGSAPDIAGKNIANPSGLLNAAVMM 288

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727863570 314 LRYgLNAPKEAEAIEAAVRKVLDDtsiggrGLYTRDLGGE------ASTADITKAVVEELEK 369
Cdd:PRK09222 289 LVH-IGQFDIAELIENAWLKTLED------GIHTADIYNEgvskkkVGTKEFAEAVIENLGQ 343
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 6-369 4.54e-30

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 119.06  E-value: 4.54e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   6 IVVLPGDHIGPEIVASALEVLK-VVEKK-RPELKLEFEEHKIGGASIDAYGTPLTDETVKACLEAdGVllgAVGGPEWTn 83
Cdd:COG0538   21 IPFIEGDGIGPEITRAIWKVIDaAVEKAyGGKRDIEWKEVDAGEKARDETGDWLPDETAEAIKEY-GV---GIKGPLTT- 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  84 pncrPEQGLLK-----LRKSMGVWANLRPcnfaskslVKY-----SPLK-PEIVegvDFCVVRELTGGCY---------- 142
Cdd:COG0538   96 ----PVGGGWRslnvtIRQILDLYVCRRP--------VRYfkgvpSPVKhPEKV---DIVIFRENTEDIYagiewkagsp 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 143 -------FGERTE-------DNGSGYAMDtwPYSLEEVSRIARLAAWLAETSNPPaPVTLLDKANVL-ATSRLWRKTVAK 207
Cdd:COG0538  161 ealklifFLEDEMgvtvirfPEDSGIGIK--PVSDEGTERLVRAAIQYALDNKRK-SVTLVHKGNIMkFTEGAFKDWGYE 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 208 IFKEEYPH-------------------LTLKNQLIDSAAMLLVKSPRTLNgVVLTDNLFGDIISDEASVIPGSLGLLPSA 268
Cdd:COG0538  238 VAEEEFGDkfitegpwekykgpkpagkIVYKDRIADDMLQQILLRPGEYD-VIATKNLNGDYISDALAAQVGGLGIAPGA 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 269 SLSGVVGkseekvhCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYgLNAPKEAEAIEAAVRKVLDDtsiggrGLYTR 348
Cdd:COG0538  317 NIGDDGG-------AEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRH-RGWLEAADLIEKAVEKTIES------GKVTY 382

                        410       420
                 ....*....|....*....|....*..
gi 727863570 349 DL------GGEASTADITKAVVEELEK 369
Cdd:COG0538  383 DLarlmegATELSTSEFGDAIIENLDK 409
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
6-353 2.61e-25

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 105.68  E-value: 2.61e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   6 IVVLPGDHIGPEIVASALEVL-KVVEKKRPELK-LEFEEHKIGGASIDAYGTPLTDETVKACLEADGVLLGAVGGP---E 80
Cdd:PRK06451  26 ILYVEGDGIGPEITHAAMKVInKAVEKAYGSDReIKWVEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPigkG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  81 WTNPNCRpeqgllkLRKSMGVWANLRPcnfaskslVKY-----SPLKPEivEGVDFCVVRELTGGCYFG----------- 144
Cdd:PRK06451 106 WKSINVA-------IRLMLDLYANIRP--------VKYipgieSPLKNP--EKIDLIIFRENTDDLYRGieypydseeak 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 145 ------------ERTEDNGSGYAmdtwPYSLEEVSRIARLAAWLAeTSNPPAPVTLLDKANVLATS----RLWRKTVA-- 206
Cdd:PRK06451 169 kirdflrkelgvEVEDDTGIGIK----LISKFKTQRIARMAIKYA-IDHKRKKVTIMHKGNVMKYTegafREWAYEVAlk 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 207 ----KIFKEEYPH-----------LTLKNQLIDSAAMLLVKSPRTLNgVVLTDNLFGDIISDEASVIPGSLGLLPSASLS 271
Cdd:PRK06451 244 efrdYVVTEEEVTknyngvppsgkVIINDRIADNMFQQIIIRPDEYD-IILAPNVNGDYISDAAGALVGNIGMLGGANIG 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 272 GVVGkseekvhcLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYgLNAPKEAEAIEAAV------RKVLDDTS--IGGR 343
Cdd:PRK06451 323 DTGG--------MFEAIHGTAPKYAGKNVANPTGIIKGGELMLRF-MGWDKAADLIDKAImesikqKKVTQDLArfMGVR 393

                        410
                 ....*....|
gi 727863570 344 GLYTRDLGGE 353
Cdd:PRK06451 394 ALSTTEYTDE 403
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 6-368 1.97e-20

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 91.08  E-value: 1.97e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570   6 IVVLPGDHIGPEIVASALEVLKVVEKkrpelKLEFEEHKIGGASIDAygTPLTDETV---KACLEadGVLLGAVGGpewt 82
Cdd:PLN00123  33 VTLIPGDGIGPLVTGAVEQVMEAMHA-----PVYFERYEVHGDMKKV--PEEVLESIrrnKVCLK--GGLATPVGG---- 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  83 npncrPEQGL-LKLRKSMGVWANLRPC-NFaskslvkysPLKPEIVEGVDFCVVRELTGGCYFG-ERTEDNGSGYAMDTW 159
Cdd:PLN00123 100 -----GVSSLnVQLRKELDLFASLVNCfNL---------PGLPTRHENVDIVVIRENTEGEYSGlEHEVVPGVVESLKVI 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 160 PYSLEEvsRIARLAAWLAETSNPPApVTLLDKANVLATSR-LWRKTVAKIFKeEYPHLTLKNQLIDSAAMLLVKSPRTLN 238
Cdd:PLN00123 166 TKFCSE--RIAKYAFEYAYLNNRKK-VTAVHKANIMKLADgLFLESCREVAK-KYPGIKYNEIIVDNCCMQLVSKPEQFD 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 239 gVVLTDNLFGDIISDEASVIPGSLGLLPsaslSGVVGKSeekvHCLVEPIHGSA----PDIAGKGIVNPVGTILSASLLL 314
Cdd:PLN00123 242 -VMVTPNLYGNLVANTAAGIAGGTGVMP----GGNVGAD----HAVFEQGASAGnvgnEKLVEQKKANPVALLLSSAMML 312

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 727863570 315 RYgLNAPKEAEAIEAAVRKVLDDtsiggrGLY-TRDLGGEASTADITKAVVEELE 368
Cdd:PLN00123 313 RH-LQFPSFADRLETAVKRVIAE------GKYrTKDLGGSSTTQEVVDAVIANLD 360
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 11-333 1.48e-14

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 74.33  E-value: 1.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  11 GDHIGPEIVASALEVLKV-VEKK-RPELKLEFEEHKIGGASIDAYGTP--LTDETVKACLEadgvLLGAVGGPEWTnpnc 86
Cdd:PRK07006  27 GDGIGPDITPAMLKVVDAaVEKAyKGERKISWMEIYAGEKATKVYGEDvwLPEETLDLIRE----YRVAIKGPLTT---- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570  87 rPEQGLLK-----LRKSMGVWANLRPcnfaskslVKY-----SPLK-PEIVEGVDFcvvRELTGGCYFG----ERTED-- 149
Cdd:PRK07006  99 -PVGGGIRslnvaLRQELDLYVCLRP--------VRYfkgvpSPVKrPEDTDMVIF---RENSEDIYAGiewkAGSAEak 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 150 ------------------NGSGYAMDtwPYSLEEVSRIARLAAWLAETSNPPApVTLLDKANVLATS----RLWRKTVAK 207
Cdd:PRK07006 167 kvikflqeemgvkkirfpETSGIGIK--PVSEEGTERLVRAAIEYAIDNDRKS-VTLVHKGNIMKFTegafKDWGYQLAE 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863570 208 ifkEEYphltlKNQLIDSAAMLLVKSPRTLNGVVLTD-----------------------NLFGDIISDEASVIPGSLGL 264
Cdd:PRK07006 244 ---EEF-----GDELIDGGPWDKIKNPETGKEIIVKDsiadaflqqillrpaeydviatmNLNGDYISDALAAQVGGIGI 315

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727863570 265 LPSASLSgvvgkseeKVHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYgLNAPKEAEAIEAAVRK 333
Cdd:PRK07006 316 APGANIN--------DGHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRH-MGWTEAADLIIKSMEK 375
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
240-316 2.58e-06

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 48.94  E-value: 2.58e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727863570 240 VVLTDNLFGDIISDEASVIPGSLGLLPSASlsgvVGKSEekvhCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRY 316
Cdd:PRK07362 355 ILATLNLNGDYISDAAAAIVGGLGMAPGAN----IGDNA----AIFEATHGTAPKHAGLDRINPGSVILSGVMMLEY 423
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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