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Conserved domains on  [gi|728866287|gb|AIY87466|]
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aminotransferase class IV [Thermotoga sp. Cell2]

Protein Classification

aminotransferase class IV( domain architecture ID 10087399)

aminotransferase class IV family protein similar to Thermotoga maritima probable branched-chain amino acid aminotransferase IlvE which may catalyze the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLPDE_IV cd00449
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ...
 29-259 3.35e-75

PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.


:

Pssm-ID: 238254 [Multi-domain]  Cd Length: 256  Bit Score: 229.80  E-value: 3.35e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  29 AVYETLRTYNGIPFAAYKHYSRLKRSVDFFKIPFSLSFDEFSKVLKTG-AQEFKQEVRIKVYLFPDSGEIFFVFSPFNVP 107
Cdd:cd00449    9 GVFEGLRAGKGRLFRLDEHLDRLNRSAKRLGLPIPYDREELREALKELvAANNGASLYIRPLLTRGVGGLGVAPPPSPEP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 108 DV--------------ESGVDVKISSVRRIPDLSTPPTLKITGRTDIVLARREIVD--CYDVILLGLNGQVCEGSFSNVF 171
Cdd:cd00449   89 TFvvfaspvgayakggEKGVRLITSPDRRRAAPGGTGDAKTGGNLNSVLAKQEAAEagADEALLLDDNGYVTEGSASNVF 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 172 LVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPVRRLNEHLFFEEEPGPV 251
Cdd:cd00449  169 IVKDGELVTPPLDGGILPGITRDSVIELAKELGIKVEERPISLDELYAADEVFLTGTAAEVTPVTEIDGRGIGDGKPGPV 248


                 ....*...
gi 728866287 252 TATLMENF 259
Cdd:cd00449  249 TRKLRELL 256
 
Name Accession Description Interval E-value
PLPDE_IV cd00449
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ...
 29-259 3.35e-75

PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.


Pssm-ID: 238254 [Multi-domain]  Cd Length: 256  Bit Score: 229.80  E-value: 3.35e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  29 AVYETLRTYNGIPFAAYKHYSRLKRSVDFFKIPFSLSFDEFSKVLKTG-AQEFKQEVRIKVYLFPDSGEIFFVFSPFNVP 107
Cdd:cd00449    9 GVFEGLRAGKGRLFRLDEHLDRLNRSAKRLGLPIPYDREELREALKELvAANNGASLYIRPLLTRGVGGLGVAPPPSPEP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 108 DV--------------ESGVDVKISSVRRIPDLSTPPTLKITGRTDIVLARREIVD--CYDVILLGLNGQVCEGSFSNVF 171
Cdd:cd00449   89 TFvvfaspvgayakggEKGVRLITSPDRRRAAPGGTGDAKTGGNLNSVLAKQEAAEagADEALLLDDNGYVTEGSASNVF 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 172 LVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPVRRLNEHLFFEEEPGPV 251
Cdd:cd00449  169 IVKDGELVTPPLDGGILPGITRDSVIELAKELGIKVEERPISLDELYAADEVFLTGTAAEVTPVTEIDGRGIGDGKPGPV 248


                 ....*...
gi 728866287 252 TATLMENF 259
Cdd:cd00449  249 TRKLRELL 256
IlvE COG0115
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ...
 1-260 7.77e-72

Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439885 [Multi-domain]  Cd Length: 285  Bit Score: 221.99  E-value: 7.77e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287   1 MLIWWRGKFQCADEISLdfSLFEKSLQ-G-AVYETLRTYNGIPFAAYKHYSRLKRSVDFFKIPFSLSFDEFSKVLKTGAQ 78
Cdd:COG0115    1 RLIWLNGELVPEEEATI--SVLDRGLHyGdGVFEGIRAYDGRLFRLDEHLARLNRSAKRLGIPIPYTEEELLEAIRELVA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  79 EFK-QEVRIKVYLF----------PDSGEIFFVF-SPFNVPDV---ESGVDVKISSVRRIPDlSTPPTLKITGRTDIVLA 143
Cdd:COG0115   79 ANGlEDGYIRPQVTrgvggrgvfaEEYEPTVIIIaSPLPAYPAeayEKGVRVITSPYRRAAP-GGLGGIKTGNYLNNVLA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 144 RREIVD--CYDVILLGLNGQVCEGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESD 221
Cdd:COG0115  158 KQEAKEagADEALLLDTDGYVAEGSGSNVFIVKDGVLVTPPLSGGILPGITRDSVIELARELGIPVEERPISLEELYTAD 237

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 728866287 222 EMFLTHTSVGVVPVRRLNEHLFFEEEPGPVTATLMENFE 260
Cdd:COG0115  238 EVFLTGTAAEVTPVTEIDGRPIGDGKPGPVTRRLRELYT 276
Aminotran_4 pfam01063
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ...
 29-238 7.87e-58

Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.


Pssm-ID: 395844 [Multi-domain]  Cd Length: 221  Bit Score: 184.10  E-value: 7.87e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287   29 AVYETLRTYNGIPFAAYKHYSRLKRSVDFFKIPFSLSFDEFSKVLKTGAQEFKQE---VRIKV-------YLFPDSGEIF 98
Cdd:pfam01063   1 GVFETLRVYNGKIFFLDEHLARLRRSAKLLGIPLPFDEEDLRKIIEELLKANGLGvgrLRLTVsrgpggfGLPTSDPTLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287   99 FVFSPFNvPDVESGVDVKISSVRRIPDLSTPPTLKITGRTDIVLARREIV--DCYDVILLGLNGQVCEGSFSNVFLVKEG 176
Cdd:pfam01063  81 IFVSALP-PPPESKKKGVISSLVRRNPPSPLPGAKTLNYLENVLARREAKaqGADDALLLDEDGNVTEGSTSNVFLVKGG 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 728866287  177 KLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPVRRL 238
Cdd:pfam01063 160 TLYTPPLESGILPGITRQALLDLAKALGLEVEERPITLADLQEADEAFLTNSLRGVTPVSSI 221
PRK06606 PRK06606
branched-chain amino acid transaminase;
29-259 1.36e-41

branched-chain amino acid transaminase;


Pssm-ID: 235841  Cd Length: 306  Bit Score: 144.90  E-value: 1.36e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  29 AVYETLRTYNG-----IpFAAYKHYSRLKRSVDFFKIPFSLSFDEFSKVLKtgaqEFKQEVRIK-VYLFPdsgeifFVF- 101
Cdd:PRK06606  35 GVFEGIRAYDTpkgpaI-FRLREHTKRLFNSAKILRMEIPYSVDELMEAQR----EVVRKNNLKsAYIRP------LVFv 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 102 -------SPFNVPD-----------------VESGVDVKISSVRRIPDLSTPPTLKITGR-TDIVLARREIVDC-YD-VI 154
Cdd:PRK06606 104 gdeglgvRPHGLPTdvaiaawpwgaylgeeaLEKGIRVKVSSWTRHAPNSIPTRAKASGNyLNSILAKTEARRNgYDeAL 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 155 LLGLNGQVCEGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVP 234
Cdd:PRK06606 184 LLDVEGYVSEGSGENIFIVRDGVLYTPPLTSSILEGITRDTVITLAKDLGIEVIERRITRDELYIADEVFFTGTAAEVTP 263

                        250       260
                 ....*....|....*....|....*
gi 728866287 235 VRRLNEHLFFEEEPGPVTATLMENF 259
Cdd:PRK06606 264 IREVDGRQIGNGKRGPITEKLQSAY 288
ilvE_I TIGR01122
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ...
 29-259 2.32e-37

branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130192  Cd Length: 298  Bit Score: 133.64  E-value: 2.32e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287   29 AVYETLRTYNG----IPFAAYKHYSRLKRSVDFFKIPFSLSFDEFSKVLKTGAQEFKQE---VRIKVY-------LFPDS 94
Cdd:TIGR01122  26 GVFEGIRAYDTdkgpAIFRLKEHIQRLYDSAKIYRMEIPYSKEELMEATRETLRKNNLRsayIRPLVFrgdgdlgLNPRA 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287   95 G---EIFFVFSPFNV----PDVESGVDVKISSVRRIPDLSTPPTLKITGR-TDIVLARREIVDC-YD-VILLGLNGQVCE 164
Cdd:TIGR01122 106 GykpDVIIAAWPWGAylgeEALEKGIDAKVSSWRRNAPNTIPTAAKAGGNyLNSLLAKSEARRHgYDeAILLDVEGYVAE 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  165 GSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPVRRLNEHLFF 244
Cdd:TIGR01122 186 GSGENIFIVKDGVLFTPPVTSSILPGITRDTVITLAKELGIEVVEQPISREELYTADEAFFTGTAAEITPIREVDGRKIG 265

                         250
                  ....*....|....*
gi 728866287  245 EEEPGPVTATLMENF 259
Cdd:TIGR01122 266 NGRRGPVTKKLQEAF 280
 
Name Accession Description Interval E-value
PLPDE_IV cd00449
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ...
 29-259 3.35e-75

PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.


Pssm-ID: 238254 [Multi-domain]  Cd Length: 256  Bit Score: 229.80  E-value: 3.35e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  29 AVYETLRTYNGIPFAAYKHYSRLKRSVDFFKIPFSLSFDEFSKVLKTG-AQEFKQEVRIKVYLFPDSGEIFFVFSPFNVP 107
Cdd:cd00449    9 GVFEGLRAGKGRLFRLDEHLDRLNRSAKRLGLPIPYDREELREALKELvAANNGASLYIRPLLTRGVGGLGVAPPPSPEP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 108 DV--------------ESGVDVKISSVRRIPDLSTPPTLKITGRTDIVLARREIVD--CYDVILLGLNGQVCEGSFSNVF 171
Cdd:cd00449   89 TFvvfaspvgayakggEKGVRLITSPDRRRAAPGGTGDAKTGGNLNSVLAKQEAAEagADEALLLDDNGYVTEGSASNVF 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 172 LVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPVRRLNEHLFFEEEPGPV 251
Cdd:cd00449  169 IVKDGELVTPPLDGGILPGITRDSVIELAKELGIKVEERPISLDELYAADEVFLTGTAAEVTPVTEIDGRGIGDGKPGPV 248


                 ....*...
gi 728866287 252 TATLMENF 259
Cdd:cd00449  249 TRKLRELL 256
IlvE COG0115
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ...
 1-260 7.77e-72

Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439885 [Multi-domain]  Cd Length: 285  Bit Score: 221.99  E-value: 7.77e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287   1 MLIWWRGKFQCADEISLdfSLFEKSLQ-G-AVYETLRTYNGIPFAAYKHYSRLKRSVDFFKIPFSLSFDEFSKVLKTGAQ 78
Cdd:COG0115    1 RLIWLNGELVPEEEATI--SVLDRGLHyGdGVFEGIRAYDGRLFRLDEHLARLNRSAKRLGIPIPYTEEELLEAIRELVA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  79 EFK-QEVRIKVYLF----------PDSGEIFFVF-SPFNVPDV---ESGVDVKISSVRRIPDlSTPPTLKITGRTDIVLA 143
Cdd:COG0115   79 ANGlEDGYIRPQVTrgvggrgvfaEEYEPTVIIIaSPLPAYPAeayEKGVRVITSPYRRAAP-GGLGGIKTGNYLNNVLA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 144 RREIVD--CYDVILLGLNGQVCEGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESD 221
Cdd:COG0115  158 KQEAKEagADEALLLDTDGYVAEGSGSNVFIVKDGVLVTPPLSGGILPGITRDSVIELARELGIPVEERPISLEELYTAD 237

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 728866287 222 EMFLTHTSVGVVPVRRLNEHLFFEEEPGPVTATLMENFE 260
Cdd:COG0115  238 EVFLTGTAAEVTPVTEIDGRPIGDGKPGPVTRRLRELYT 276
Aminotran_4 pfam01063
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ...
 29-238 7.87e-58

Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.


Pssm-ID: 395844 [Multi-domain]  Cd Length: 221  Bit Score: 184.10  E-value: 7.87e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287   29 AVYETLRTYNGIPFAAYKHYSRLKRSVDFFKIPFSLSFDEFSKVLKTGAQEFKQE---VRIKV-------YLFPDSGEIF 98
Cdd:pfam01063   1 GVFETLRVYNGKIFFLDEHLARLRRSAKLLGIPLPFDEEDLRKIIEELLKANGLGvgrLRLTVsrgpggfGLPTSDPTLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287   99 FVFSPFNvPDVESGVDVKISSVRRIPDLSTPPTLKITGRTDIVLARREIV--DCYDVILLGLNGQVCEGSFSNVFLVKEG 176
Cdd:pfam01063  81 IFVSALP-PPPESKKKGVISSLVRRNPPSPLPGAKTLNYLENVLARREAKaqGADDALLLDEDGNVTEGSTSNVFLVKGG 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 728866287  177 KLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPVRRL 238
Cdd:pfam01063 160 TLYTPPLESGILPGITRQALLDLAKALGLEVEERPITLADLQEADEAFLTNSLRGVTPVSSI 221
D-AAT_like cd01558
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ...
 4-259 7.23e-49

D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.


Pssm-ID: 238799 [Multi-domain]  Cd Length: 270  Bit Score: 162.77  E-value: 7.23e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287   4 WWRGKFQCADEISLdfSLFEKSLQGA--VYETLRTYNGIPFAAYKHYSRLKRSVDFFKIPFSLSFDEFSKVL-----KTG 76
Cdd:cd01558    1 YLNGEYVPREEAKV--SVFDRGFLFGdgVYEVIRVYNGKPFALDEHLDRLYRSAKELRIDIPYTREELKELIrelvaKNE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  77 AQEfkQEVRIKV--------YLFPDSGE---IFFVF--SPFNVPDVESGVDVKISSVRRIPDlstpPTLKITGRTDIVLA 143
Cdd:cd01558   79 GGE--GDVYIQVtrgvgprgHDFPKCVKptvVIITQplPLPPAELLEKGVRVITVPDIRWLR----CDIKSLNLLNNVLA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 144 RREIVD--CYDVILLGLNGQVCEGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESD 221
Cdd:cd01558  153 KQEAKEagADEAILLDADGLVTEGSSSNVFIVKNGVLVTPPLDNGILPGITRATVIELAKELGIPVEERPFSLEELYTAD 232

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 728866287 222 EMFLTHTSVGVVPVRRLNEHLFFEEEPGPVTATLMENF 259
Cdd:cd01558  233 EVFLTSTTAEVMPVVEIDGRPIGDGKPGPVTKRLREAY 270
ADCL_like cd01559
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent ...
 29-259 6.44e-42

ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.


Pssm-ID: 238800 [Multi-domain]  Cd Length: 249  Bit Score: 143.99  E-value: 6.44e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  29 AVYETLRTYNGIPFAAYKHYSRLKRSVDffkipfSLSFDEFSK------VLKTGAQEFKQEVRIKVYL--------FPDS 94
Cdd:cd01559    9 GVFETMRALDGRLFLLDAHLARLERSAR------RLGIPEPDLprlraaLESLLAANDIDEGRIRLILsrgpggrgYAPS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  95 GE----IFFVFSPFNVPDVESGVDVKISSVRRiPDLSTPPTLKITGRTDIVLARREIVD--CYDVILLGLNGQVCEGSFS 168
Cdd:cd01559   83 VCpgpaLYVSVIPLPPAWRQDGVRLITCPVRL-GEQPLLAGLKHLNYLENVLAKREARDrgADEALFLDTDGRVIEGTAS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 169 NVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPVRRLNEHLFfeeEP 248
Cdd:cd01559  162 NLFFVKDGELVTPSLDRGGLAGITRQRVIELAAAKGYAVDERPLRLEDLLAADEAFLTNSLLGVAPVTAIDDHDG---PP 238

                        250
                 ....*....|.
gi 728866287 249 GPVTATLMENF 259
Cdd:cd01559  239 GPLTRALRELL 249
PRK06606 PRK06606
branched-chain amino acid transaminase;
29-259 1.36e-41

branched-chain amino acid transaminase;


Pssm-ID: 235841  Cd Length: 306  Bit Score: 144.90  E-value: 1.36e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  29 AVYETLRTYNG-----IpFAAYKHYSRLKRSVDFFKIPFSLSFDEFSKVLKtgaqEFKQEVRIK-VYLFPdsgeifFVF- 101
Cdd:PRK06606  35 GVFEGIRAYDTpkgpaI-FRLREHTKRLFNSAKILRMEIPYSVDELMEAQR----EVVRKNNLKsAYIRP------LVFv 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 102 -------SPFNVPD-----------------VESGVDVKISSVRRIPDLSTPPTLKITGR-TDIVLARREIVDC-YD-VI 154
Cdd:PRK06606 104 gdeglgvRPHGLPTdvaiaawpwgaylgeeaLEKGIRVKVSSWTRHAPNSIPTRAKASGNyLNSILAKTEARRNgYDeAL 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 155 LLGLNGQVCEGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVP 234
Cdd:PRK06606 184 LLDVEGYVSEGSGENIFIVRDGVLYTPPLTSSILEGITRDTVITLAKDLGIEVIERRITRDELYIADEVFFTGTAAEVTP 263

                        250       260
                 ....*....|....*....|....*
gi 728866287 235 VRRLNEHLFFEEEPGPVTATLMENF 259
Cdd:PRK06606 264 IREVDGRQIGNGKRGPITEKLQSAY 288
ilvE_I TIGR01122
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ...
 29-259 2.32e-37

branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130192  Cd Length: 298  Bit Score: 133.64  E-value: 2.32e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287   29 AVYETLRTYNG----IPFAAYKHYSRLKRSVDFFKIPFSLSFDEFSKVLKTGAQEFKQE---VRIKVY-------LFPDS 94
Cdd:TIGR01122  26 GVFEGIRAYDTdkgpAIFRLKEHIQRLYDSAKIYRMEIPYSKEELMEATRETLRKNNLRsayIRPLVFrgdgdlgLNPRA 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287   95 G---EIFFVFSPFNV----PDVESGVDVKISSVRRIPDLSTPPTLKITGR-TDIVLARREIVDC-YD-VILLGLNGQVCE 164
Cdd:TIGR01122 106 GykpDVIIAAWPWGAylgeEALEKGIDAKVSSWRRNAPNTIPTAAKAGGNyLNSLLAKSEARRHgYDeAILLDVEGYVAE 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  165 GSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPVRRLNEHLFF 244
Cdd:TIGR01122 186 GSGENIFIVKDGVLFTPPVTSSILPGITRDTVITLAKELGIEVVEQPISREELYTADEAFFTGTAAEITPIREVDGRKIG 265

                         250
                  ....*....|....*
gi 728866287  245 EEEPGPVTATLMENF 259
Cdd:TIGR01122 266 NGRRGPVTKKLQEAF 280
PRK07650 PRK07650
4-amino-4-deoxychorismate lyase; Provisional
 30-266 1.62e-36

4-amino-4-deoxychorismate lyase; Provisional


Pssm-ID: 181067  Cd Length: 283  Bit Score: 130.86  E-value: 1.62e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  30 VYETLRTYNGIPFAAYKHYSRLKRSVDFFKIPFSLSFDEFSKVLKT--GAQEFKQE-VRIKVY-------LFPDS----G 95
Cdd:PRK07650  29 VFETFRIYNGHPFLLDDHYDRLNDALDTLQIEWTMTKDEVLLILKNllEKNGLENAyVRFNVSagigeigLQTEMyeepT 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  96 EIFFVfSPFNVPDVESGVDVKISSVRRipdlSTPPT---LKITGRTDIVLARREIVDCYDV--ILLGLNGQVCEGSFSNV 170
Cdd:PRK07650 109 VIVYM-KPLAPPGLPAEKEGVVLKQRR----NTPEGafrLKSHHYLNNILGKREIGNDPNKegIFLTEEGYVAEGIVSNL 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 171 FLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPVRRLNEHLFFEEEpGP 250
Cdd:PRK07650 184 FWVKGDIVYTPSLETGILNGITRAFVIKVLEELGIEVKEGFYTKEELLSADEVFVTNSIQEIVPLTRIEERDFPGKV-GM 262

                        250
                 ....*....|....*.
gi 728866287 251 VTATLMENFEPFVLNL 266
Cdd:PRK07650 263 VTKRLQNLYEMQREKL 278
BCAT_beta_family cd01557
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ...
 29-252 4.61e-35

BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.


Pssm-ID: 238798  Cd Length: 279  Bit Score: 126.93  E-value: 4.61e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  29 AVYETLRTYNGIP-----FAAYKHYSRLKRSVDFFKIPfSLSFDEFSKVLKTGAQEFKQEVRIK----VYLFP----DSG 95
Cdd:cd01557   14 AVFEGLKAYRTPDgkivlFRPDENAERLNRSARRLGLP-PFSVEEFIDAIKELVKLDADWVPYGggasLYIRPfifgTDP 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  96 EI---------FFVF-SPFNV--PDVESGVDVKISSVRRIPDlstpptlKITGRTDI-------VLARREIVD--CYDVI 154
Cdd:cd01557   93 QLgvspaleylFAVFaSPVGAyfKGGEKGVSALVSSFRRAAP-------GGPGAAKAggnyaasLLAQKEAAEkgYDQAL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 155 LL-GLNGQVCEGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVV 233
Cdd:cd01557  166 WLdGAHGYVAEVGTMNIFFVKDGELITPPLDGSILPGITRDSILELARDLGIKVEERPITRDELYEADEVFATGTAAVVT 245

                        250       260
                 ....*....|....*....|.
gi 728866287 234 PVRRLNEH--LFFEEEPGPVT 252
Cdd:cd01557  246 PVGEIDYRgkEPGEGEVGPVT 266
PRK08320 PRK08320
branched-chain amino acid aminotransferase; Reviewed
 110-263 1.79e-32

branched-chain amino acid aminotransferase; Reviewed


Pssm-ID: 236238 [Multi-domain]  Cd Length: 288  Bit Score: 120.36  E-value: 1.79e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 110 ESGVDVKISSVRRIPDLSTPPTLKITGRTDIVLARRE--IVDCYDVILLGLNGQVCEGSFSNVFLVKEGKLITPSLDSGI 187
Cdd:PRK08320 128 EKGLKVITVSTRRNRPDALSPQVKSLNYLNNILAKIEanLAGVDEAIMLNDEGYVAEGTGDNIFIVKNGKLITPPTYAGA 207

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 728866287 188 LDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPVRRLNEHLFFEEEPGPVTATLMENFEPFV 263
Cdd:PRK08320 208 LEGITRNAVIEIAKELGIPVREELFTLHDLYTADEVFLTGTAAEVIPVVKVDGRVIGDGKPGPITKKLLEEFRELT 283
PRK07544 PRK07544
branched-chain amino acid aminotransferase; Validated
 29-263 4.08e-28

branched-chain amino acid aminotransferase; Validated


Pssm-ID: 181025  Cd Length: 292  Bit Score: 108.91  E-value: 4.08e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  29 AVYETLRTYNGIPFAAYKHYSRLKRSVDF--FKIPFSLsfDEF-------------------------SKVLKTGAQEFK 81
Cdd:PRK07544  37 SVFEGERAYGGKIFKLREHSERLRRSAELldFEIPYSV--AEIdaakketlaangltdayvrpvawrgSEMMGVSAQQNK 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  82 QEVRIKVYLFPdsgeiffvfSPFNVPDVESGVDVKISSVRRiPDLSTPPT-LKITGRTDIVLA---RREIVDCYDVILLG 157
Cdd:PRK07544 115 IHLAIAAWEWP---------SYFDPEAKMKGIRLDIAKWRR-PDPETAPSaAKAAGLYMICTIskhAAEAKGYADALMLD 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 158 LNGQVCEGSFSNVFLVKEGKLITPSLDSgILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPVRR 237
Cdd:PRK07544 185 YRGYVAEATGANIFFVKDGVIHTPTPDC-FLDGITRQTVIELAKRRGIEVVERHIMPEELAGFSECFLTGTAAEVTPVSE 263

                        250       260
                 ....*....|....*....|....*.
gi 728866287 238 LNEHLFfeeEPGPVTATLMENFEPFV 263
Cdd:PRK07544 264 IGEYRF---TPGAITRDLMDDYEALV 286
PRK06680 PRK06680
D-amino acid aminotransferase; Reviewed
 20-262 7.87e-27

D-amino acid aminotransferase; Reviewed


Pssm-ID: 180656 [Multi-domain]  Cd Length: 286  Bit Score: 105.40  E-value: 7.87e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  20 SLFEKSLQGA--VYETLRTYNGIPFAAYKHYSRLKRSVDFFKIPFSLSFDEFSKVLKtgaqEFKQEVRIK---VYLFPDS 94
Cdd:PRK06680  20 HIEDRGFQFAdgIYEVCAVRDGKLVDLDRHLARLFRSLGEIRIAPPMTRAELVEVLR----ELIRRNRVReglVYLQVTR 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  95 GEIF--FVFSPfnvPDVESGVDVkisSVRRIPDLSTPPTLK-----IT------GRTDI--------VLARREIVD--CY 151
Cdd:PRK06680  96 GVARrdHVFPA---ADVKPSVVV---FAKSVDFARPAAAAEtgikvITvpdnrwKRCDIksvgllpnVLAKQAAKEagAQ 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 152 DVILLGlNGQVCEGSFSNVFLV-KEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSV 230
Cdd:PRK06680 170 EAWMVD-DGFVTEGASSNAWIVtKDGKLVTRPADNFILPGITRHTLIDLAKELGLEVEERPFTLQEAYAAREAFITAASS 248

                        250       260       270
                 ....*....|....*....|....*....|..
gi 728866287 231 GVVPVRRLNEHLFFEEEPGPVTATLMENFEPF 262
Cdd:PRK06680 249 FVFPVVQIDGKQIGNGKPGPIAKRLREAYEEF 280
PRK12479 PRK12479
branched-chain-amino-acid transaminase;
30-260 1.12e-26

branched-chain-amino-acid transaminase;


Pssm-ID: 183549 [Multi-domain]  Cd Length: 299  Bit Score: 105.42  E-value: 1.12e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  30 VYETLRTYNGIPFAAYKHYSRLKRSVDFFKIPFSLSFDEFSK-VLKTGAQEFKQEVRIKVYLFPDSGEIFFVFSPFNVPD 108
Cdd:PRK12479  33 VFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPLTVDEMEEaVLQTLQKNEYADAYIRLIVSRGKGDLGLDPRSCVKPS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 109 V---------------ESGVDV-KISSVRRIPDlSTPPTLKITGRTDIVLARREIVDC--YDVILLGLNGQVCEGSFSNV 170
Cdd:PRK12479 113 ViiiaeqlklfpqefyDNGLSVvSVASRRNTPD-ALDPRIKSMNYLNNVLVKIEAAQAgvLEALMLNQQGYVCEGSGDNV 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 171 FLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPVRRLNEHLFFEEEPGP 250
Cdd:PRK12479 192 FVVKDGKVLTPPSYLGALEGITRNSVIELCERLSIPCEERPFTRHDVYVADEVFLTGTAAELIPVVKVDSREIGDGKPGS 271

                        250
                 ....*....|
gi 728866287 251 VTATLMENFE 260
Cdd:PRK12479 272 VTKQLTEEFK 281
PRK06092 PRK06092
4-amino-4-deoxychorismate lyase; Reviewed
 110-260 1.47e-22

4-amino-4-deoxychorismate lyase; Reviewed


Pssm-ID: 235696  Cd Length: 268  Bit Score: 93.75  E-value: 1.47e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 110 ESGVDVKISSVRripdLSTPPTL---KITGRTDIVLARREIVDC--YDVILLGLNGQVCEGSFSNVFLVKEGKLITPSLD 184
Cdd:PRK06092 118 EQGITLALCPTR----LGRNPLLagiKHLNRLEQVLIRAELEQTeaDEALVLDSEGWVIECCAANLFWRKGGVVYTPDLD 193

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 728866287 185 -SGIlDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPVRRLNEHLFfeeEPGPVTATLMENFE 260
Cdd:PRK06092 194 qCGV-AGVMRQFILELLAQSGYPVVEVDASLEELLQADEVFICNSLMPVWPVRAIGETSY---SSGTLTRYLQPLCE 266
PRK12400 PRK12400
D-amino acid aminotransferase; Reviewed
 21-259 1.89e-22

D-amino acid aminotransferase; Reviewed


Pssm-ID: 171470  Cd Length: 290  Bit Score: 93.93  E-value: 1.89e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  21 LFEKSLQ--GAVYETLRTYNGIPFAAYKHYSRLKRSVDffKIPFSLSFDefskvlktgaqefKQEVRIKVYL------FP 92
Cdd:PRK12400  25 LEERGLQfgDGVYEVIRLYKGNFHLLDPHITRLYRSME--EIELTLPFS-------------KAELITLLYKliennnFH 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  93 DSGEIFF-----------VFSpFNVPDVesgVDVKISSVRR--------IPDLSTPPTLKItgRTDI--------VLA-- 143
Cdd:PRK12400  90 EDGTIYLqvsrgvqarthTFS-YDVPPT---IYAYITKKERpalwieygVRAISEPDTRWL--RCDIkslnllpnILAat 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 144 RREIVDCYDVILLgLNGQVCEGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEM 223
Cdd:PRK12400 164 KAERKGCKEALFV-RNGTVTEGSHSNFFLIKNGTLYTHPANHLILNGIIRQYVLSLAKTLRIPVQEELFSVRDVYQADEC 242

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 728866287 224 FLTHTSVGVVPVRRLNEHLFFEEEPGPVTATLMENF 259
Cdd:PRK12400 243 FFTGTTIEILPMTHLDGTAIQDGQVGPITKMLQRSF 278
PRK13356 PRK13356
branched-chain amino acid aminotransferase;
92-253 2.87e-15

branched-chain amino acid aminotransferase;


Pssm-ID: 237362  Cd Length: 286  Bit Score: 73.84  E-value: 2.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  92 PDSGEIFFVFSPFNVP-DVESGVDVKISSVRRiPDLSTPPT------LKITGRTDIVLARREIVDcyDVILLGLNGQVCE 164
Cdd:PRK13356 110 PDPESTRFALCLEEAPmPEPTGFSLTLSPFRR-PTLEMAPTdakagcLYPNNARALREARSRGFD--NALVLDMLGNVAE 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 165 GSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPVRRLNEHLFf 244
Cdd:PRK13356 187 TATSNVFMVKDGVVFTPVPNGTFLNGITRQRVIALLREDGVTVVETTLTYEDFLEADEVFSTGNYSKVVPVTRFDDRSL- 265


                 ....*....
gi 728866287 245 eeEPGPVTA 253
Cdd:PRK13356 266 --QPGPVTR 272
PRK07849 PRK07849
aminodeoxychorismate lyase;
30-241 5.17e-15

aminodeoxychorismate lyase;


Pssm-ID: 236114 [Multi-domain]  Cd Length: 292  Bit Score: 73.07  E-value: 5.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  30 VYETLRTYNGIPFAAYKHYSRLKRSVDFFKIPfSLSFDEFSKVLKTGAQEFKQEVR---IKVYLF-------PDSGEIFF 99
Cdd:PRK07849  41 VFETLLVRDGRPCNLEAHLERLARSAALLDLP-EPDLDRWRRAVELAIEEWRAPEDeaaLRLVYSrgresggAPTAWVTV 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 100 VFSPFNVPDV-ESGVDVkISSVRRIP-DLSTP-PTLKITGRTdivL-----------ARREIVDcyDVILLGLNGQVCEG 165
Cdd:PRK07849 120 SPVPERVARArREGVSV-ITLDRGYPsDAAERaPWLLAGAKT---LsyavnmaalryAARRGAD--DVIFTSTDGYVLEG 193

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 728866287 166 SFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPVRRLNEH 241
Cdd:PRK07849 194 PTSTVVIATDDRLLTPPPWYGILPGTTQAALFEVAREKGWDCEYRALRPADLFAADGVWLVSSVRLAARVHTLDGR 269
PRK13357 PRK13357
branched-chain amino acid aminotransferase; Provisional
 169-255 8.65e-15

branched-chain amino acid aminotransferase; Provisional


Pssm-ID: 237363  Cd Length: 356  Bit Score: 73.26  E-value: 8.65e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 169 NVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFES------DEMFLTHTSVGVVPVRRL---- 238
Cdd:PRK13357 237 NFFFITKDGTVTPPLSGSILPGITRDSLLQLAEDLGLTVEERPVSIDEWQADaasgefTEAFACGTAAVITPIGGIkykd 316

                         90
                 ....*....|....*..
gi 728866287 239 NEHLFFEEEPGPVTATL 255
Cdd:PRK13357 317 KEFVIGDGEVGPVTQKL 333
PLN02782 PLN02782
Branched-chain amino acid aminotransferase
 164-235 1.28e-13

Branched-chain amino acid aminotransferase


Pssm-ID: 215418  Cd Length: 403  Bit Score: 69.88  E-value: 1.28e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 728866287 164 EGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPV 235
Cdd:PLN02782 285 EVSSCNIFIVKDNVISTPAIKGTILPGITRKSIIDVARSQGFQVEERNVTVDELLEADEVFCTGTAVVVSPV 356
PLN02883 PLN02883
Branched-chain amino acid aminotransferase
 164-235 1.44e-11

Branched-chain amino acid aminotransferase


Pssm-ID: 178471  Cd Length: 384  Bit Score: 63.97  E-value: 1.44e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 728866287 164 EGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPV 235
Cdd:PLN02883 267 EVSAANIFLVKGNIIVTPATSGTILGGITRKSIIEIALDLGYKVEERRVPVEELKEAEEVFCTGTAAGVASV 338
PRK07546 PRK07546
hypothetical protein; Provisional
 152-197 7.22e-10

hypothetical protein; Provisional


Pssm-ID: 169002 [Multi-domain]  Cd Length: 209  Bit Score: 57.30  E-value: 7.22e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 728866287 152 DVILLGLNGQVCEGSFSNVFL-VKEGKLITPSLDSGILDGITRENVI 197
Cdd:PRK07546 127 EVILLNERGEVCEGTITNVFLdRGGGMLTTPPLSCGLLPGVLRAELL 173
PLN02259 PLN02259
branched-chain-amino-acid aminotransferase 2
 164-235 1.20e-09

branched-chain-amino-acid aminotransferase 2


Pssm-ID: 177901  Cd Length: 388  Bit Score: 58.19  E-value: 1.20e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 728866287 164 EGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPV 235
Cdd:PLN02259 271 EASSCNVFVVKGRTISTPATNGTILEGITRKSVMEIASDQGYQVVEKAVHVDEVMDADEVFCTGTAVVVAPV 342
PLN02845 PLN02845
Branched-chain-amino-acid aminotransferase-like protein
 29-257 2.24e-09

Branched-chain-amino-acid aminotransferase-like protein


Pssm-ID: 215454 [Multi-domain]  Cd Length: 336  Bit Score: 56.95  E-value: 2.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287  29 AVYETLRTYNGIPFAAYKHYSRLKRSVDFFKI--PFSLSFDEfSKVLKTGAQEFKQEVRIKVYLFPDSGEifFVFSPFN- 105
Cdd:PLN02845  69 GVFDTATIRDGHLYELDAHLDRFLRSAAKAKIplPFDRATLR-RILLQTVAASGCRNGSLRYWLSAGPGG--FSLSPSGc 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 106 --------------VPDVESGVDVKISSVrriPdlSTPP---TLKITGRTDIVLARREIVD--CYDVILLGLNGQVCEGS 166
Cdd:PLN02845 146 sepafyavviedtyAQDRPEGVKVVTSSV---P--IKPPqfaTVKSVNYLPNALSQMEAEErgAFAGIWLDEEGFVAEGP 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 167 FSNV-FLVKEGKLITPSLDSgILDGITRENVIKLAKSLEIP-----VEERVVWVWELFESDEMFLTHTSVGVVPVRRLNE 240
Cdd:PLN02845 221 NMNVaFLTNDGELVLPPFDK-ILSGCTARRVLELAPRLVSPgdlrgVKQRKISVEEAKAADEMMLIGSGVPVLPIVSWDG 299

                        250
                 ....*....|....*..
gi 728866287 241 HLFFEEEPGPVTATLME 257
Cdd:PLN02845 300 QPIGDGKVGPITLALHD 316
PLN03117 PLN03117
Branched-chain-amino-acid aminotransferase; Provisional
 164-241 3.00e-09

Branched-chain-amino-acid aminotransferase; Provisional


Pssm-ID: 178664  Cd Length: 355  Bit Score: 56.86  E-value: 3.00e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 728866287 164 EGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESDEMFLTHTSVGVVPVRRLNEH 241
Cdd:PLN03117 234 ELSACNIFILKGNIVSTPPTSGTILPGVTRKSISELARDIGYQVEERDVSVDELLEAEEVFCTGTAVVVKAVETVTFH 311
PRK09266 PRK09266
hypothetical protein; Provisional
 142-248 6.46e-06

hypothetical protein; Provisional


Pssm-ID: 236438  Cd Length: 266  Bit Score: 46.51  E-value: 6.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866287 142 LARREIVDcyDVILLGLNGQVCEGSFSNVFLVKEGKLITPslDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFESD 221
Cdd:PRK09266 147 LAQRAGFD--DALFVDPDGRVSEGATWNLGFWDGGAVVWP--QAPALPGVTMALLQRGLERLGIPQRTRPVTLADLGRFA 222

                         90       100
                 ....*....|....*....|....*..
gi 728866287 222 EMFLTHTSVGVVPVRRLNEHLFFEEEP 248
Cdd:PRK09266 223 GAFACNAWRGQRAVSAIDDVALPDSHA 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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