|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
27-436 |
1.20e-161 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 461.81 E-value: 1.20e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 27 IVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVd 106
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 107 ifsgfGIIVALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFM 186
Cdd:TIGR00893 80 -----GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 187 GGLGIVISFIWLKVIHEPNQHPGVNKKELEYIAAGGALINMDQqntkvKVPFSVKWGQIKQLLGSRMMIGVYIGQYCINA 266
Cdd:TIGR00893 155 GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQG-----KGPSTPKKYQIKELLKDRRVWGLALGQFLVNI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 267 LTYFFITWFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMRRTGSLNIARKTPIVMGMLLSMVMVFCNYV 346
Cdd:TIGR00893 230 GLGFFLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYV 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 347 NVEWMIIGFMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGALIYVGVHAL 426
Cdd:TIGR00893 310 NIPYAALALVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALAL 389
|
410
....*....|
gi 732683370 427 IAVLSYLVLV 436
Cdd:TIGR00893 390 IGALSYLLLV 399
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
18-435 |
1.88e-107 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 322.21 E-value: 1.88e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 18 RYWIVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSM 97
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 98 FTLLQGFVDIFSGFgiivalFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEV 177
Cdd:cd17319 81 FTALTGFATSLTSL------YVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 178 GWSHVFFFMGGLGIVISFIWLKVIhepnqhpgvnkkeleyiaaggalinmdqqntkvkvpfsvkwgqikqllgsRMMIGV 257
Cdd:cd17319 155 GWRWAFIIEGLLGLLLAVLWWFYL--------------------------------------------------RQVWGL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 258 YIGQYCINALTYFFITWFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMRrtgslnIARKTPIVMGMLLS 337
Cdd:cd17319 185 ALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLR------GARRLVIIIGLLLA 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 338 MVMVFCNYVNV-EWMIIGFMALAFFGKGIGALGWAVMADTA-PKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFN 415
Cdd:cd17319 259 AVGLLLAYLTTsPVVAVILLSLAGFGIGAASPVFWSLPADLlPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYT 338
|
410 420
....*....|....*....|
gi 732683370 416 GALIYVGVHALIAVLSYLVL 435
Cdd:cd17319 339 AAFLFLAAVALLAALLVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-441 |
8.56e-70 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 225.52 E-value: 8.56e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 13 KRTNARYWIVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSI 92
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 93 FIWSMFTLLQGFVDIFsgfgiiVALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGW 172
Cdd:COG2271 83 LLWGLATLLFGFATSF------WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 173 LTHEVGWSHVFFFMGGLGIVISFIwlkvihepnqhpgvnkkeleyiaaggalinmdqqntkvkvpfsvkwgqikqllgsr 252
Cdd:COG2271 157 LLAAFGWRAAFLILGLPGLLLALL-------------------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 253 MMIGVYIGQYCINALTYFFITWFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMRRtgslniaRKTPIVM 332
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-------RKLVLAI 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 333 GMLLSMV-MVFCNYVNVEWMIIGFMALA-FFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGT 410
Cdd:COG2271 254 GLLLAALaLLLLALLPSPALAIALLFLAgFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA 333
|
410 420 430
....*....|....*....|....*....|.
gi 732683370 411 TGsFNGALIYVGVHALIAVLSYLVLVGDIKR 441
Cdd:COG2271 334 TG-YQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
26-418 |
7.35e-64 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 210.70 E-value: 7.35e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 26 FIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFV 105
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 106 DIFSgfgiivALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMG-WLTHEVGWSHVFF 184
Cdd:TIGR00881 81 TSLW------VMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLfGIAELYSWHWVFI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 185 FMGGLGIVISFIWLKVIHEPNQHPGVNKKELEYIAAggalinMDQQNTKVKVPFSVKWGQIKQLLGSRMMIGVYIGQYCI 264
Cdd:TIGR00881 155 VPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEE------PDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 265 NALTYFFITWFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMRRT-GSLNIARKTPIVMGMLLSMVMVFC 343
Cdd:TIGR00881 229 YVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRrGPLAVFFMALIIVSLLVYWLNPAA 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 732683370 344 NYVnveWMIIGFMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGsFNGAL 418
Cdd:TIGR00881 309 NPL---MDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG-WAGAF 379
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
22-434 |
3.02e-51 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 176.98 E-value: 3.02e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 22 VVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLL 101
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 102 QGFVdifsGFGIIVALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSH 181
Cdd:cd17380 81 TPLL----AYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 182 VFFFMGGLGIVISFIWLKVIhepnqhPGVnkkeleyiaaggalinmdqqntkvkvpfsvkWgqikqllgsrmmiGVYIGQ 261
Cdd:cd17380 157 VFYFFGLLGLLWALVWLIYL------PPV-------------------------------W-------------AIIVAH 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 262 YCINALTYFFITWFPVYLVQARGmSILKAGFVASVPAVCGFIGGVLGGIISDWLMRRTGSLNIARKTPIVMGMLLSMV-M 340
Cdd:cd17380 187 FCMNWGFYILLSWLPTYFHEVLV-PLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALfL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 341 VFCNYVNVEWMIIGFMALAFFGKGIGALGWAV-MADTAPKEiSGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGALI 419
Cdd:cd17380 266 LLLSHTDSFSLALLCMSVALGLSAFSSSGVLVnHQDIAPNY-AGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFV 344
|
410
....*....|....*
gi 732683370 420 YVGVHALIAVLSYLV 434
Cdd:cd17380 345 LAAVVNLVGAVVFLL 359
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
14-408 |
2.55e-48 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 170.11 E-value: 2.55e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 14 RTNARYWIVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIF 93
Cdd:cd17318 15 RVNLSVAIVAMVNSTATHDNNNTSTDKDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSIL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 94 IWSMFTLLqgfVDIFSGFGIiVALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWL 173
Cdd:cd17318 95 ITALLTLL---TPLAARGGY-GALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 174 THEVGWSHVFFFMGGLGIVISFIWLKVIhepnqhpgvnkkeleyiaaggalinmdqqntkvkVPFsvkWGQIkqllgsrm 253
Cdd:cd17318 171 CESLGWPSIFYIFGGLGLLWCLLWFFLV----------------------------------LPV---WAIV-------- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 254 migvyIGQYCINALTYFFITWFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMRRTG-SLNIARKTPIVM 332
Cdd:cd17318 206 -----VAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIlSTTTVRKLFTSI 280
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 732683370 333 GMLLSMVMVFC-NYVNVE-WMIIGFMALAFFGKGIGALGWAV-MADTAPKeISGLSGGLFNMFGNISGIVTPIAIGYIV 408
Cdd:cd17318 281 GFLGPGVFLIAlGYLGSNaTLAVVFLTLSVGLSGACYSGFLVnHLDLAPN-YAGTLMGITNTAATIAGIISPLIVGAIV 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-435 |
6.81e-45 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 160.82 E-value: 6.81e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 18 RYWIVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSM 97
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 98 FTLLQGFVDIFsgfgiiVALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEV 177
Cdd:COG2223 83 GLLLLALAVSY------WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 178 GWSHVFFFMGGLGIVISFIWLKVIHEPNQHPGVNKKeleyiaaggalinmdqqntkvkvpfsVKWGQIKQLLGSRMMIGV 257
Cdd:COG2223 157 GWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK--------------------------ASLRDQLEALRDPRFWLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 258 YIGQYCINALTYFFITWFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMRRTGSLniarktPIVMGMLLS 337
Cdd:COG2223 211 SLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLL------IVFALMALG 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 338 MVMVFCNYVNVEWMIIGFMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGA 417
Cdd:COG2223 285 LLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAA 364
|
410
....*....|....*...
gi 732683370 418 LIYVGVHALIAVLSYLVL 435
Cdd:COG2223 365 FLVFAVLALVALVLTLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
18-397 |
6.57e-34 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 130.09 E-value: 6.57e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 18 RYWIVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSM 97
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 98 FTLLQGFVDIFsgfgiiVALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEV 177
Cdd:COG2814 88 GSLLCALAPSL------WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 178 GWSHVFFFMGGLGIVISFIWLKVIHEPNQHPGVNKKeleyiaaggalinmdqqntkvkvpfsvkwGQIKQLLGSRMMIGV 257
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLR-----------------------------GSLRELLRRPRLLLL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 258 YIGQYCINALTYFFITWFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWlmrrtgslnIARKTPIVMGMLLS 337
Cdd:COG2814 213 LLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR---------FGRRRLLLIGLLLL 283
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 732683370 338 MV--MVFCNYVNVEWMIIGFMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISG 397
Cdd:COG2814 284 ALglLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
58-431 |
1.25e-32 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 128.71 E-value: 1.25e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 58 GYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLqgfVDIFSGFGIIVALFtLRFLVGLAEAPSFPGNSR 137
Cdd:TIGR00894 79 GLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIV---IPWAAGGGIALVVF-CRVIQGLAQGSVSPATHK 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 138 IVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHE-VGWSHVFFFMGGLGIVISFIWLKVIHE-PNQHPGVNKKEL 215
Cdd:TIGR00894 155 IIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADdPSIHPCISKFEK 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 216 EYiaaggalINMDQQNTKVKVPFSVKWgqiKQLLGSRMMIGVYIGQYCINALTYFFITWFPVYLVQARGMSILKAGFVAS 295
Cdd:TIGR00894 235 KY-------INSSLQGQKGSTRQSLPI---KAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSS 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 296 VPAVCGFIGGVLGGIISDWL-MRRTGSLNIARKTPIVMGMLLSMVMVFCNYV---NVEWMIIGFMALAFFGKGIGALGWA 371
Cdd:TIGR00894 305 LPYLFAWLCSIFAGYLADFLkSSKTLSLTAARKIFNGIGGLGPGIFAYALPYlsaAFYLTIIILTLANAVSSGPLAGVLI 384
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 372 VMADTAPKeISGLSGGLFNMFGNISGIVTPIAIGYIVgTTGSFNGALIYVGVHALIAVLS 431
Cdd:TIGR00894 385 NSLDLAPR-FLGFIKGITGLPGFIGGLIASTLAGNIL-SQDSKNVWLIVFLIMAFVNILC 442
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
47-433 |
5.09e-32 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 125.38 E-value: 5.09e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 47 AKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFsgfgiiVALFTLRFLVGL 126
Cdd:cd17325 23 AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY------WQLLLARFLQGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 127 AEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFMGGLGIVISFIWLKVIHEPNq 206
Cdd:cd17325 97 ASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPR- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 207 hpgvnkkeleyiaaggalinmdQQNTKVKVPFSVKWGQIKQLLGSRMMIGVYIGQYCINALTYFFITWFPVYLVQARGMS 286
Cdd:cd17325 176 ----------------------PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 287 ILKAGFVASVPAVCGFIGGVLGGIISDWlmrrtgslnIARKTPIVMGMLLSMVMVFC-NYVNVEWMIIGFMALAFFGKGI 365
Cdd:cd17325 234 PAQIGLLFGAQGLASALSQPPAGKLSDR---------IGRKPLILIGLLLSAVALLLlPLATSFWLLLLLLALLGLGLGL 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 732683370 366 GALGW-AVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGALIYVGVHALIAVLSYL 433
Cdd:cd17325 305 VFPATlALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
46-430 |
4.05e-31 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 123.12 E-value: 4.05e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 46 MAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVyfwsIFIWSMFTLLQGFvdIFSGFGIIVALFTLRFLVG 125
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRV----LAVGLLLMGAAAL--LMALVGSYPVLLVLLFLVG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 126 LAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFMGGLGIVISFIWLKVIHEPN 205
Cdd:cd17475 96 AGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 206 QHPGVNKKEleyiaaggalinmdqqntkvkvpfSVKWGQIKQLLGSRMMIGVYIGQYCINALTYFFITWFPVYLVQARGM 285
Cdd:cd17475 176 AASAATESA------------------------STLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 286 SILKAGFVASVPAVCGFIGGVLGGIISDWLMRRtgslniARKTPIVMGMLLSMVMVFCNYVNVEWMIIGFMALAFFGKGI 365
Cdd:cd17475 232 SVVAAGALLAVAQLGGALGRIGLGRVSDRVFGG------RRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGL 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 366 GALGW-----AVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGALIYVGVHALIAVL 430
Cdd:cd17475 306 FAIGWnglylTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAAL 375
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
25-433 |
3.93e-30 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 120.22 E-value: 3.93e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 25 LFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGF 104
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 105 VDIFSGfgiivaLFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLT--HEVGWSHV 182
Cdd:cd06174 81 APSFWL------LLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 183 FFFMGGLGIVISFIWLKVIHEPNQHPGVNKKEleyiaaggalinmdqqntkvkVPFSVKWGQIKQLLGSRMMIGVYIGQY 262
Cdd:cd06174 155 FLIAAALALLAAILLLLVVPDPPESARAKNEE---------------------ASSKSVLKLLKRVLKNPGLWLLLLAIF 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 263 CINALTYFFITWFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMRRTGSLNIArktpivMGMLLSMVMVF 342
Cdd:cd06174 214 LVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIG------LLLMALGLALL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 343 CNYVNVEWMIIGFMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGALIYVG 422
Cdd:cd06174 288 LLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLA 367
|
410
....*....|.
gi 732683370 423 VHALIAVLSYL 433
Cdd:cd06174 368 VLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
25-401 |
6.15e-29 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 116.36 E-value: 6.15e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 25 LFIVTSFNYGDRATLSIA-GSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQG 103
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 104 FVDIFsgfgiiVALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVF 183
Cdd:pfam07690 81 FASSL------WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 184 FFMGGLGIVISFIWLKVIHEPNQHPGVNKKELEYIAAGGalinmdqqntkvkvpfsvkwgqIKQLLGSRMMIGVyIGQYC 263
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA----------------------WKALLRDPVLWLL-LALLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 264 INALTYFFITWFPVYlVQARGMSILKAGFVASVPAvcgfIGGVLGGIISDWLMRRTGSLNIARKTPIVMGMLLSMVMVFC 343
Cdd:pfam07690 212 FGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGG----LLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLS 286
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 732683370 344 NYVNVEWMIIGFMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTP 401
Cdd:pfam07690 287 LTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
22-375 |
2.27e-27 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 113.10 E-value: 2.27e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 22 VVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLL 101
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 102 QGFVDIFSgfgiivALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEV-GWS 180
Cdd:cd17328 81 SSFAPNFW------QLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 181 HVFFFMGGLGIVISFIWLKVIHEPnqhpgvnkkeleyiaAGGALINMDQQNTKVkvpfSVKWGQIKQLLGSRMMIGVYIG 260
Cdd:cd17328 155 WAFRVTGVLGVLLAILLLLFVREP---------------PRGAAEGGVMAKSTA----TSFLADLKALAKNPSFILSTLG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 261 QYCINALTYFFITWFPVYLVQARGMSILKAGFVA----SVPAVCGFIGGVLGGIISDWLMRRTGSlniARKTPIVMGMLL 336
Cdd:cd17328 216 FTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGlifgAITCIAGVLGVLLGGILADRLRRKTPR---ADPLVCAVGLLA 292
|
330 340 350
....*....|....*....|....*....|....*....
gi 732683370 337 SMVMVFCNYVNVEWMIIGFMALAFFGKGIGALGWAVMAD 375
Cdd:cd17328 293 AAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFA 331
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
18-430 |
2.20e-26 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 109.29 E-value: 2.20e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 18 RYWIVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSM 97
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 98 FTLLQGFVDIFSGFGIivalftLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEV 177
Cdd:cd17312 81 ANIFMGFSTSLWFFAV------LWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 178 GWSHVFFFMGGLGIVISFIWLKVIHEPNQHpgvnkkeleyiaaggalinmdqqntkvkvpfsvkwgqikqllgsrmMIGV 257
Cdd:cd17312 155 GWRAAFLVPGIVGLVVAIILFFFLRDSPPY----------------------------------------------VWVL 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 258 YIGQYCINALTYFFITWFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMRRTgslniaRKTPIVMGMLLS 337
Cdd:cd17312 189 SLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGR------RAPIAVIYMLLM 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 338 MV--MVFCNYVNVEWMIIGFMALA--FFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGS 413
Cdd:cd17312 263 TLslALFWFFPHNKLLSIVLLFLIgfFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGW 342
|
410
....*....|....*..
gi 732683370 414 FNGALIYVGVHALIAVL 430
Cdd:cd17312 343 STVFYFLISAALLSVLL 359
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
22-433 |
3.27e-23 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 100.37 E-value: 3.27e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 22 VVMLFIVTSFNYGDRATLSIAGSEMAKDI--GLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFT 99
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 100 LLQGFVDIFsgfgiiVALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTH---- 175
Cdd:cd17316 81 LLIGLLPTP------ILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsg 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 176 EVGWSHVFFFMGGLGIVISFIWLKVIhepnqhpgvnkkeleyiaaggalinmdqqntkvkvpfsvkwgqikqllgsrMMI 255
Cdd:cd17316 155 DWGWRILFLIGALPALLALLLRRRTL---------------------------------------------------LLI 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 256 GVYIgqyCINALTYFFITWFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMRRTGSLniarkTPIVMGML 335
Cdd:cd17316 184 LLWF---FISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLV-----IGLILSGI 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 336 LSMVMVFCNYVNVEWMIIGFMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFN 415
Cdd:cd17316 256 LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTG 335
|
410
....*....|....*...
gi 732683370 416 GALIYVGVHALIAVLSYL 433
Cdd:cd17316 336 VPALILALLAIVALIVAL 353
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
9-408 |
3.83e-23 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 100.51 E-value: 3.83e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 9 SSVEKRTNARYWIVVML--FIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKR 86
Cdd:TIGR00895 4 NNIRKQPLSRYQWRAIIlsFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 87 VYFWSIFIWSMFTLLQGFVDIFSGFGIivalftLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIF 166
Cdd:TIGR00895 84 VLLWSILLFSVFTLLCALATNVTQLLI------LRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 167 APIMGWLTHEVGWSHVFFFMGGLGIVISFIWLKVIHEPNQHPGVNKKELEYIAAGGALINMDQQNTKVKVPFSVKWGQIK 246
Cdd:TIGR00895 158 GFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 247 QLLG-------SRMMIGVYIGQYCINALTYFFITWFPVYLVQARGMSILKAGFVASVPAvcgfiGGVLGGIISDWLMRRT 319
Cdd:TIGR00895 238 SVFKalfqgktARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNF-----GGVIGSIIFGWLADRL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 320 GSLNIArKTPIVMGMLLSMVMVFCNYVNVeWMIIGFMALAFFGKGIGALGwAVMADTAPKEISGLS-GGLFNMfGNISGI 398
Cdd:TIGR00895 313 GPRVTA-LLLLLGAVFAVLVGSTLFSPTL-LLLLGAIAGFFVNGGQSGLY-ALMALFYPTAIRATGvGWAIGI-GRLGAI 388
|
410
....*....|
gi 732683370 399 VTPIAIGYIV 408
Cdd:TIGR00895 389 IGPILAGYLL 398
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
19-403 |
5.32e-23 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 100.40 E-value: 5.32e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 19 YWIVVMLFIVTSFNYGDRATLSIAG-SEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSM 97
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAvMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 98 FTLLQGFVDIFSGfgiivaLFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATvIFAPIMGWLTHEV 177
Cdd:cd17327 84 LTLLTAAVKNFGG------LIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGS-IFGGLLAYGVFKI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 178 -------GWSHVFFFMGGLGI---VISFIWLKVIHEPNqhPGVNKKELEYiaaggALINMDQQNTKvKVPFSVKWGQIKQ 247
Cdd:cd17327 157 lgvgglaGWRWLFIIEGLITIiigLVIFFWLPDNPSKA--WFLTEEEKEL-----AVERLRANQTG-KGDQKFKWKQIKE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 248 LLGSRMMIGVYIGQYCINALTYFFITWFPVyLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMRRTGSLNIArk 327
Cdd:cd17327 229 AFKDPRTWLLFLFFFCSQITNNGISNFLPL-ILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFA-- 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 732683370 328 tpIVMGMLLSMVMVFCNYVNVEWMIIGFMALAFFGKGIGALGWAVmADTAPKEISGLSGGLFNMFGNISGIVTPIA 403
Cdd:cd17327 306 --CVLALVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWIS-SNCAGYTKRATVLAIMLIFYNVGNIVAPQI 378
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
58-407 |
5.42e-22 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 97.16 E-value: 5.42e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 58 GYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGF-VDIFSGFgiivaLFTLRFLVGLAEAPSFPGNS 136
Cdd:cd17381 68 GWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLaADLGAGY-----LIAVRALEGLGEGVTFPAMH 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 137 RIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFMGGLGIVISFIWLKVIhepnqhpgvnkkele 216
Cdd:cd17381 143 AMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV--------------- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 217 yiaaggalinmdqqntkvkVPFsvkWGQIkqllgsrmmigvyIGQYCINALTYFFITWFPVYLVQARGMSILKAGFVASV 296
Cdd:cd17381 208 -------------------MPL---WAIV-------------VAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSAL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 297 PAVCGFIGGVLGGIISDWLMRRTG-SLNIARKTPIVMGMLLSMVMVF------CNYVnvewMIIGFMALAFFGKGIGALG 369
Cdd:cd17381 253 PYLGCWLFMILSGQIADNLREKQNfSTVCVRKIFTLIGMIGPAVFLLaagftgCNYS----LAVAFLTISSTLGGFSASG 328
|
330 340 350
....*....|....*....|....*....|....*....
gi 732683370 370 WAV-MADTAPKeISGLSGGLFNMFGNISGIVTPIAIGYI 407
Cdd:cd17381 329 FNInHLDIAPS-YAGILLGITNTFATIPGMVGPVIAKSL 366
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
51-430 |
1.17e-21 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 96.22 E-value: 1.17e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 51 GLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSGFGIivalftLRFLVGLAEAP 130
Cdd:cd17371 30 GLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLI------LRALAGLGFGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 131 SFPGNSRIVAAWFPAQERGTAVSIFNSAQY----FATVIFAPIMGWLTHEVGWSHVFFFMGGLGIVISFIWLKViHEPNQ 206
Cdd:cd17371 104 EWAAGAALMAEYVPARHRGKALGYVQSGWAvgwlLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFV-KEPPQ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 207 HPGVNKK--ELEYIAAGGALINMDQQNTkvkvpfsvkwgqikQLLGSRMMIGVYIGQYCINaltyffiTWFPVYLVQARG 284
Cdd:cd17371 183 WQAARAArrHFADRPSLRELFSPPLLRT--------------TLLASLLATGALGGYYGIT-------TWLPSYLTGERG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 285 MSILKAGFVASVPAVCGFIGGVLGGIISDWLMRRTGSLNIArktpivMGMLLSMVMVFCNYVNVEWMIIGFMALAFFGKG 364
Cdd:cd17371 242 LSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFA------LGSAISILLYFFLPLSPTLILILGFPLGFFASG 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 732683370 365 IGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVgTTGSFNGALIYVGVHALIAVL 430
Cdd:cd17371 316 PFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLA-TSGSLGTAIAVFAAVYYIAGL 380
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
5-435 |
6.86e-21 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 94.17 E-value: 6.86e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 5 SQAASSVEKRTNARYWIVVMLFIVTSFNYgdRATLSIAG---SEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDR 81
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNL--RPAITSVGpllPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 82 FGSKRVyfwsiFIWSMFTLLQGFVdIFSGFGIIVALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQeRGTAVSIFNSAQYF 161
Cdd:COG2807 80 FGLERT-----LLLALLLLAAGLL-LRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 162 ATVIFAPIMGWLTHEVGWSHVFFFMGGLGIVISFIWLKVIHEPNQHPGVnkkeleyiAAGGAlinmdqqntkvkvpfsvk 241
Cdd:COG2807 153 GAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAA--------APAAA------------------ 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 242 wgQIKQLLGSRMMIGVYIGQYCINALTYFFITWFPVYLvQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLmrrtgs 321
Cdd:COG2807 207 --SLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRL------ 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 322 lniARKTPIVMGMLLSMV--MVFCNYVNVEWMIIGFMALAFFGKGIGALGWAVMADTA--PKEISGLSgGLFNMFGNISG 397
Cdd:COG2807 278 ---GDRRPLLLLLGLLGLagLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRArtPAEAAALS-GMAQSVGYLLA 353
|
410 420 430
....*....|....*....|....*....|....*...
gi 732683370 398 IVTPIAIGYIVGTTGSFNGALIYVGVHALIAVLSYLVL 435
Cdd:COG2807 354 ALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
25-435 |
8.51e-21 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 93.94 E-value: 8.51e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 25 LFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLlqgf 104
Cdd:cd17343 8 MFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTV---- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 105 vdIFSGFGIIVALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFF 184
Cdd:cd17343 84 --AFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 185 FMGGLGIVISFIWLKVIHEPNQHPGVNKKELEYiaaggalinmdQQNTKVKVPFSVkwGQIKQLLGSRMMIGVYIGqYCI 264
Cdd:cd17343 162 ISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEE-----------SKGKKKKSPRGE--STLKELLLSPFLWLLSLG-YLV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 265 NALTYFFIT-WFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMRRTGSLNiarKTPIVMGMLLSMVM--- 340
Cdd:cd17343 228 VFGVKTAVTdWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSS---RGNPRMPLALVFMAglt 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 341 ----VFCNYVNVEWMIIgFMALAFFGKGIGALG----WAVMA-DTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTT 411
Cdd:cd17343 305 vslhLFRVHITSDSSEL-FILLLGFLIGFSLYGpiaiFGVIAnESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHY 383
|
410 420
....*....|....*....|....
gi 732683370 412 GsFNGALIYVGVHALIAVLSYLVL 435
Cdd:cd17343 384 D-WRTAFLLLEILCAITVVILFLL 406
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
44-436 |
6.39e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 87.99 E-value: 6.39e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 44 SEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSgfgiivALFTLRFL 123
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA------LLLLARAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 124 VGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFMGGLGIVISF-IWLKVIH 202
Cdd:cd17324 97 AGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALlLWRLLPS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 203 EPNQHPGVNKKELEYIAaggalinmdqqntkvkvpfsvkwgqikqLLGSRMMIGVYIGQYCINALTYFFITWFPVYLVQA 282
Cdd:cd17324 177 LPPKKPGSLGLLSSLLL----------------------------LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 283 RGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMRRTgslniarktpIVMGMLLSMVMVFCNYVNVEWMIIGFMALAFFG 362
Cdd:cd17324 229 PGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRA----------LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWG 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 732683370 363 KGIGALG---WAVMADTAPkEISGLSGGLFNMFGNISgivtpIAIGYIVGTTGSFNGALIYVGVHALIAVLSYLVLV 436
Cdd:cd17324 299 LGFFAAHsalQTRVLRLAP-EARGLASSLYLAAYNLG-----GALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
35-399 |
5.73e-18 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 84.92 E-value: 5.73e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 35 DRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSgfgii 114
Cdd:cd17321 11 DVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLA----- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 115 vALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFMGGLGIVIs 194
Cdd:cd17321 86 -FLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 195 fiwlkvihepnqhpgvnkkeleyiaaggalinmdqqntkvkvpfsvkwgqikqLLGSRMMIGVYIGQYCINALTYFFITW 274
Cdd:cd17321 164 -----------------------------------------------------LLLARTFSGAVLAAFLLGAALGGLLFL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 275 FPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGiisdWLMRRTGSlniarKTPIVMGMLLSMV----MVFCNYVNVEW 350
Cdd:cd17321 191 LPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAG----RLADRFGP-----RLVLVAGLLLTAVglllLALLGADSSVW 261
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 732683370 351 MIIGFMALAFFGKGI-GALGWAVMADTAPKEISGLSGGLFNMFGNISGIV 399
Cdd:cd17321 262 LLLPGLVLLGLGLGLfATPLTNAALSSVPKEKAGAASGILNTARQLGGAL 311
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
26-435 |
6.72e-18 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 85.37 E-value: 6.72e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 26 FIVTSFNYGD----RATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLL 101
Cdd:cd17345 5 FLGIFIGYAGyylvRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINIL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 102 QGFVDifSGFGIIVALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVG--- 178
Cdd:cd17345 85 IGFVP--SATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgw 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 179 WSHVFFFMGGLGIVISFIWLKVIHEPNQHPGVNKKElEYIAAGGALINMDQQNTKvkvpFSVKWGQIKQLLGSRMMIGVY 258
Cdd:cd17345 163 WRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIE-EYKGDYPEEADGEEEEQE----LSAWEIFVKYVLKNKLLWYIA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 259 IGQYCINALTYFFITWFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMR-RTGSLNIarktpIVMGMLLS 337
Cdd:cd17345 238 IANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKgRRAPTGI-----IFMILVIV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 338 MVMVFCNYVNVEWMIIGFMALAFFGKGIGAL-GWAVMaDTAPKEISGLSGGLFNMFGNISG-IVTPIAIGYIVGTTGsFN 415
Cdd:cd17345 313 ALIVYWLAPNVLVDLIALIALGFLIYGPVMLiGLQAL-ELVPKKAAGTAAGLTGLFGYLGGsVLATALIGIIVDHFG-WN 390
|
410 420
....*....|....*....|
gi 732683370 416 GALIYVGVHALIAVLSYLVL 435
Cdd:cd17345 391 GGFIVLLASCILAIIFLALV 410
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
13-434 |
1.46e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 84.14 E-value: 1.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 13 KRTNARYWIVVMLFIVTSFNYgdrATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSI 92
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFAT---ALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 93 FIWSMFTLLQGFVDIFSGFgiIVALFTLRFLVGLAEAPSFPgnsriVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGW 172
Cdd:COG0738 81 LLMALGLLLFALAPSYPLL--LLALFLLGLGLGLLDVAANP-----YVAALGPETAASRLNLLHAFFSLGALLGPLLGGL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 173 LTH---EVGWSHVFFFMGGLGIVISFIWLKVihepnQHPGVNKKELEYIAAGGALinmdqqntkvkvpfsvkwgqiKQLL 249
Cdd:COG0738 154 LILlglSLSWHLPYLILAVLLLLLALLFLRS-----KLPEIEEEEEEAAGSAASL---------------------KSLL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 250 GSRMMIGVYIGQYCINALTYFFITWFPVYLVQARGMSILKAGFVASVpavcGFIGGVLGGIISDWLMRRTGSLNIARKTP 329
Cdd:COG0738 208 KNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSL----FWGGMTIGRFLGGFLLKRFGPVRLLRLSA 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 330 IVMGMLLSMVMVFcnyVNVEWMIIGFMALAFFGKGIGALGWAVMADTAPKEiSGLSGGLFNMFGNISGIVTPIAIGYIVG 409
Cdd:COG0738 284 LLAAVGLLLALLA---PGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLAD 359
|
410 420
....*....|....*....|....*
gi 732683370 410 TTGSFNGALIYVGVHALIAVLSYLV 434
Cdd:COG0738 360 AFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
41-436 |
2.46e-17 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 83.47 E-value: 2.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 41 IAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSGfgiivaLFTL 120
Cdd:PRK11551 36 VAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS------LLVA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 121 RFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVfFFMGGLG-IVISFIWLK 199
Cdd:PRK11551 110 RLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHI-FYVGGVGpLLLVPLLMR 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 200 VIHEPNQhpgvnkkeleYIAAGGAlinmdqqnTKVKVPFSvkwgqiKQLLG---SRMMIGVYIGQYCINALTYFFITWFP 276
Cdd:PRK11551 189 WLPESRA----------FAQAAGA--------GKQRAPVL------RALFGegrATATLLLWISYFFTLIVLYFLLNWLP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 277 VYLVqARGMSILKAGFVAsvpavCGF-IGGVLGGIISDWLMRRtgslniARKTPIVMGMLLSMVMVFCNYVNVEWmiIGF 355
Cdd:PRK11551 245 SLLV-GQGLSRSQAGLVQ-----IAFnIGGALGSLLIGALMDR------LRPRRVVLLIYAGILASLAALAAAPS--FAG 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 356 MALAFFGKGIGALG-----WAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGALIYVGVHALIAVL 430
Cdd:PRK11551 311 MLLAGFAAGLFVVGgqsvlYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLALGRSTVGVIGASIPVILVAAL 390
|
....*.
gi 732683370 431 SYLVLV 436
Cdd:PRK11551 391 AALLLV 396
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
53-407 |
2.51e-17 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 83.16 E-value: 2.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 53 DPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSmftLLQGFVDIFSGFGIIVALFtLRFLVGLAEAPSF 132
Cdd:cd17382 47 TPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTS---TLNMLIPIAARVHYGCVIF-VRILQGLVEGVTY 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 133 PGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFMGGLGIVISFIWLKVihepnqhpgvnk 212
Cdd:cd17382 123 PACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV------------ 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 213 keleyiaaggalinmdqqntkvkvpfsvkwgqikqllgSRMMIGVYIGQYCINALTYFFITWFPVYLVQARGMSILKAGF 292
Cdd:cd17382 191 --------------------------------------SMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 293 VASVPAVCGFIGGVLGGIISDWLMRRTG-SLNIARKTPIVMGMLL-SMVMVFCNYVNVEWMIIGFMALAFFGKGIGALGW 370
Cdd:cd17382 233 LSALPHLVMTIIVPIGGQLADYLRSRGIlSTTAVRKIFNCGGFGMeATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGF 312
|
330 340 350
....*....|....*....|....*....|....*...
gi 732683370 371 AV-MADTAPKEISGLSgGLFNMFGNISGIVTPIAIGYI 407
Cdd:cd17382 313 NVnHLDIAPRYASILM-GISNGIGTLSGMVCPVIVGAL 349
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
8-200 |
7.93e-16 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 77.54 E-value: 7.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 8 ASSVEKRTNARYWIVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRV 87
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 88 YFWSIFIWSMFTLLQGFVDifsgfgIIVALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFA 167
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAP------SPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGP 155
|
170 180 190
....*....|....*....|....*....|...
gi 732683370 168 PIMGWLTHEVGWSHVFFFMGGLGIVISFIWLKV 200
Cdd:COG0477 156 LLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
45-430 |
8.11e-16 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 78.77 E-value: 8.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 45 EMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSgfgiivALFTLRFLV 124
Cdd:cd17474 24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA------LLLAGRALQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 125 GLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFaPIMGWLTHEVGWSHVFFFMGGLGIVISFIWLKVIHEP 204
Cdd:cd17474 98 GIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 205 nqhpgvnkkeleyiaaggalinmdqQNTKVKVPFSVKWGQIKQLLGsRMMIGVYIGQYCINALTYFFITWFPVYLVQARG 284
Cdd:cd17474 177 -------------------------KEKAKSSSATKLRDLKKALRG-RGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 285 MSILKAGFVASVPAVCGFIGGVLGGiisDWLMRRTGSLNiarktpIVMGMLLSMVMVFCNYVNVEWMIIGFMALAFFGKG 364
Cdd:cd17474 231 ISPIIIGLLFAGWSVLLALGSLFVG---RLLKKRFGARR------ILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLG 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 732683370 365 IG---ALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGsFNGALIYVGVHALIAVL 430
Cdd:cd17474 302 LGlnlPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG-LSAPFLVGAAIALAAAV 369
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
76-435 |
3.28e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 76.84 E-value: 3.28e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 76 GWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSgfgiivALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIF 155
Cdd:cd17473 56 GWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLY------ALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 156 NSAQYFATVIFAPIMGWLThEVGWSHVFFFMGGLGIVISFIWLKvIHEPNQHPGVNKKELEYIAAGgalinmdqqntkvk 235
Cdd:cd17473 130 SAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLLALPVLILVLLF-LPEPARKSKSAASPGAATAAA-------------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 236 vpfsvkwgqikqlLGSRMMIGVYIGQYCINALTYFFITWFPVYLVQARGMSILKAGFVASVPAvcgfIGGVLGGIISDWL 315
Cdd:cd17473 194 -------------LPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIAS----LAGAIGALLFGRL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 316 MRRTGslniARKTPIVMGMLLSMVMVFCNYVNVEWMIIGfmALAFFGKGIGALGWAVMA---DTAPKEISGLSGGLFNMF 392
Cdd:cd17473 257 KRRLG----KRRLLAIGFALMALGFLLLALASGLWVVLL--GAILAGLGFGLLLPTLNSwamSLVPPELRGRAMGIVTSA 330
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 732683370 393 GNISGIVTPIAIGYIVGTTGSFNGALIYVGVHALIAVLSYLVL 435
Cdd:cd17473 331 FFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
46-198 |
4.02e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 67.22 E-value: 4.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 46 MAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFsgfgiiVALFTLRFLVG 125
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF------WLLLLLLALLG 299
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 732683370 126 LAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFMGGLGIVISFIWL 198
Cdd:cd17325 300 LGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
20-435 |
4.47e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 67.30 E-value: 4.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 20 WIVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFT 99
Cdd:cd17355 3 VVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 100 LLQGFVDIFSGFGIIVALftlrfLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGW 179
Cdd:cd17355 83 VLLALATSLWQLYLLWGL-----LGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGW 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 180 SHVFFFMGGLGIVISFI-WLKVIHEPNQHPGVNKKELEYIAAGGALinmdqqntkvkvpfsvkwgqiKQLLGSRMMIGVY 258
Cdd:cd17355 158 RTALLVLALLALLVLVPvLLLLRRRPADLALRAYDDASPASPGSTL---------------------KEALRSASFWLLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 259 IGQYCINALTYFFITWFPVYLVQaRGMSILKAGFVASVPAVCGFIGGVLGGiisdWLMRRTGSLNIArktpivmgmLLSM 338
Cdd:cd17355 217 LAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGRLLSG----WLGDRYSPRRLL---------AASY 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 339 VMVFCNYVNVEWMIIGFMALAFFGKGIGALGWAVMADTA-------PKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTT 411
Cdd:cd17355 283 ALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAalaaryfGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRT 362
|
410 420
....*....|....*....|....
gi 732683370 412 GSFNGALIYVGVHALIAVLSYLVL 435
Cdd:cd17355 363 GSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
22-435 |
6.46e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 66.45 E-value: 6.46e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 22 VVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLL 101
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 102 QGFVDIFSGFGIivalftLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSH 181
Cdd:cd17365 81 TAFAQSVLQLAL------LRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 182 VFFFMGGLGIVIsfiwlkvihepnqhpgvnkkeleyiaaggalinmdqqntkvkVPFsvkwgqikqLLGSRMMIGVYIgq 261
Cdd:cd17365 155 VFLLGGVPPLIL------------------------------------------LPL---------LRGTLLLWVTFF-- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 262 yCINALTYFFITWFPvYLVQARGMSILKAGFVASVPAvcgfIGGVLGGIISDWLMRRTGslniaRKTPIVMGMLLSMVMV 341
Cdd:cd17365 182 -MGLLLVYLLNSWLP-KLMVEAGYSLSQALTITLLLN----IGGVIGSLLLGWLADRFG-----PKRVLALFFALGAVSL 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 342 FC--NYVNVEWMIIGFMALA-FFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGAL 418
Cdd:cd17365 251 ALlgVSPASLVLLYVLVFLAgACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVF 330
|
410
....*....|....*..
gi 732683370 419 IYVGVHALIAVLSYLVL 435
Cdd:cd17365 331 LALAIPAALGALAVLLL 347
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
18-435 |
7.92e-12 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 66.28 E-value: 7.92e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 18 RYWIVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKrvYFWSIFIwsm 97
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPR--YFMGIGL--- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 98 ftLLQGFVDIFSGFGIIVALFTLRF-LVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHE 176
Cdd:cd17488 76 --IATGIINILFGFSSSLWAFAVLWtLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 177 VGWSHVFFFMGGLGIVISFIWLKVIHEpnqhpgvnKKELEYIAAGGALInmdqqntkvkvpfsvkwgqikqllgsrmmig 256
Cdd:cd17488 154 YGWRAGMYVPGIIAILMGIVLCWRLRD--------RPPYIWLLAFCYVL------------------------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 257 VYIGQYCINaltyffiTWFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMR-RTGSLNIArktpIVMGML 335
Cdd:cd17488 195 VYVVRTAIN-------DWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKgNRGPMNLI----FALGLL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 336 LSMVMVFCNYVNVEWMIIG-FMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGsF 414
Cdd:cd17488 264 VSVGALWLVPVHSYWLLATcFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWG-W 342
|
410 420
....*....|....*....|.
gi 732683370 415 NGALIYVGVHALIAVLSYLVL 435
Cdd:cd17488 343 SGFFIVISIAAAISGLLLLPL 363
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
46-436 |
1.37e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 65.69 E-value: 1.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 46 MAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVdifsgfGIIVALFTLRFLVG 125
Cdd:cd17489 22 YAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA------TSVALLLVLRLIHG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 126 LAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFMGGLgIVISFIWLKVIHEPN 205
Cdd:cd17489 96 IGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL-ALLALLLVFLVKDPP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 206 QHPGVNKKEleyiaaggalinmdqqntKVKVPFSVKWGQIkqLLGSRMMIGVYIGQYCInaltyffITWFPVYlVQARGM 285
Cdd:cd17489 175 PVAAEEAEA------------------GTRAFRRLVEKKV--LPPALILFLASIAYGAI-------STFLPLY-AAERGI 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 286 SilKAGFVASVPAVCGFIGGVLGGIISDWLmrrtgslniARKTPIVMGMLLSMVMVFC-NYVNVEWMIIGFMALAFFGKG 364
Cdd:cd17489 227 S--NAGLFFTVYAIALLLSRPFSGKLSDRK---------GPKTVIIPGLLLLALGLLLlSFAGSPWMLLLAAVLYGLGFG 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 732683370 365 IGALGWAVMA-DTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGsFNGALIYVGVHALIAVLSYLVLV 436
Cdd:cd17489 296 LLFPALQALAvDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
50-435 |
3.51e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 64.92 E-value: 3.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 50 IGLDPVGMGYVFSAFSWAYVIGQIPGGWLLD----RFGSKRVYF-WSIFIWSMFTLLQGFVDIFSGFGIIVALFTLRFLV 124
Cdd:COG2211 41 LGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWIlIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 125 GLAEAPSFPGNSRIVAAWFP-AQERGTAVSIFNSAQYFATVIFAPIMGWLTHEV------GWSHVFFFMGGLGIVISFIW 197
Cdd:COG2211 121 GLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLT 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 198 LKVIHEPNQHPgvnkkeleyiaaggalinmdqqntKVKVPFSVKWGQIKQLLGSRMMIGVYIGQYCINALTYFFITWFPV 277
Cdd:COG2211 201 FFGTKERPVPE------------------------EEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFK 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 278 YLVqarGMSILKAGFVASVpavcGFIGGVLGGIISDWLMRRTGslniaRKTPIVMGMLLSMV----MVFCNYVNVEWMII 353
Cdd:COG2211 257 YVL---GLSAALVGLLLAL----YFLAALLGAPLWPRLAKRFG-----KKKAFIIGLLLAALglllLFFLGPGNLWLLLV 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 354 GFMALAFFGKGIGALGWAVMADTAP-------KEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGA--------- 417
Cdd:COG2211 325 LAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAaqspsaltg 404
|
410 420
....*....|....*....|
gi 732683370 418 --LIYVGVHALIAVLSYLVL 435
Cdd:COG2211 405 irLLFFLLPAVLLLLAALLL 424
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
39-430 |
4.43e-11 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 64.19 E-value: 4.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 39 LSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDifSGFGIivaLF 118
Cdd:cd17341 18 FAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAV--SSYWG---LL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 119 TLRFLVGLAEApSFPGNSRIVAAWFPAQERGTAVSIF-------NSAQYFATVIFAPIMGWLTHEVGWSHVFFFMGGLGI 191
Cdd:cd17341 93 VLGFLLGFAGA-NFASGQPWASFWFPKEKIGGAAGGIagagnmgVAVSQLLAPLIAGAIVFDGGFVGWRNAFFVPGILLA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 192 visfiwlkvihepnqhpgvnkkeleyIAAGGALINMDQQNTKvKVPFSVKWGQIKQLLGSRmmigvyigQYCINALTYF- 270
Cdd:cd17341 172 --------------------------IAAVLVLLFGDDLPTG-KASALEFLKVQLAVLKNY--------RTWILSLLYGv 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 271 ----FIT---WFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISD-WLMRRTGSLNIArktpivmGMLLSMVMVF 342
Cdd:cd17341 217 tfgsFVGfsnVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDrFGGRRRLWWLFI-------VMTIGAALLS 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 343 CNYVNVEWMIIGF---MALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGALI 419
Cdd:cd17341 290 LSLPTSGTNLVLFlalFVALGLGAGAGNGSVFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFS 369
|
410
....*....|.
gi 732683370 420 YVGVHALIAVL 430
Cdd:cd17341 370 LFGVLAVACTL 380
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
46-412 |
4.45e-11 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 64.11 E-value: 4.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 46 MAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFvdiFSGFGIIVALFtlrFLVG 125
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF---APNYWLLLLLV---ALAG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 126 LAEAPSFPGNSRIVAAWFPAQeRGTAVSIFNSAQYFATVIfAPIMGWLTHEVGWSHVFFFMGGLGIVISFIWLKVIHEPN 205
Cdd:cd17478 96 IGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFAL-GPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 206 QHPGVNKKELEYIAAggalinmdqqntkvkvPFSVKWGQIKQLLGsrMMIGVYIGQYCINaltyffiTWFPVYLVQaRGM 285
Cdd:cd17478 174 KPEAKKAAAKSSARS----------------TLKGVWRALLLLLI--IVFLRSWVLSSLT-------TFLPFYLVQ-RGY 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 286 SILKAGFVASVPAVCGFIGGVLGGIISDwlmrrtgslNIARKTPIVMGMLLSMV-MVFCNYVNVEWMIIGFMALAFFGKG 364
Cdd:cd17478 228 SLVFAGLLLSLFLFAGAIGTLIGGPLSD---------RFGRRRVIIASLLLAAPfLLLFLLTPGIWSYILLVLAGFLLFA 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 732683370 365 IGALGWAVMADTAPkEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTG 412
Cdd:cd17478 299 SFPVTVVLAQELLP-GNVGLASGLMMGLSFGLGGIGAPVLGALADAFG 345
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
56-433 |
5.38e-11 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 63.88 E-value: 5.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 56 GMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMftllqGFVDIFSGFGIIVALFTLrFLVGLAEAPSFPGN 135
Cdd:cd17333 32 DVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISL-----ALALIFATPSIYLFVVLM-FLAGLGAGILDTGA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 136 SRIVAAWFPaQERGTAVSIFNSAQYFATVIFAPIMGWL-THEVGWSHVFFFMGGLGIVISFIWLKvihepnqhpgvnkke 214
Cdd:cd17333 106 NTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLlTSELSWSWAYLIIGLIYLLLAILILL--------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 215 LEYIAAGGALINMDQQNTKVKVPFSVKWGQIKQLLGSRMMIGVYIgqycinalTYFFITWFPVYLVQARGMSILKAGFVA 294
Cdd:cd17333 170 TLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGA--------ETAFSSWVPSYLVEKKHVSDGLAGYLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 295 SVpavcGFIGGVLGGIISDWLMRRTGSlniarKTPIVMGMLLSMVMVFCNYV--NVEWMIIGFMALAFFGKGIGALGWAV 372
Cdd:cd17333 242 SG----FWVGITIGRLLGGPISRRIKP-----HTLLVLSGSGALLGLLILLLapTLVVGLVATALLGLFMAALFPTILSL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 732683370 373 MADTAPKEiSGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGALIYVGVHALIAVLSYL 433
Cdd:cd17333 313 GISNLPYA-KGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
46-433 |
8.61e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 63.40 E-value: 8.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 46 MAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSiFIWSMFTLLQGFVDIFSGFGIIVALFTLRFLVG 125
Cdd:cd06173 25 LVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILA-DLLRALLAAVLALLALLGSLSLWLLLVLAFLLG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 126 LAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFmGGLGIVISFIWLKVIHEPN 205
Cdd:cd06173 104 IASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAI-NALSFLLSALLLLFIRRPP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 206 QHPGVNKKELEYIAAGGALinmdqqntkvkvpfsvkwgqiKQLLGSRMMIGVYIGQYCINALTYFFITWFPVYLVQARGM 285
Cdd:cd06173 183 PAAPGESSSLLLRDLREGL---------------------RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 286 SILKAGFVASVPAvcgfIGGVLGGIISDWLMRRTGSlniaRKTPIVMGMLLSMVMVFCNYVNVEWMIIGFMALAFFGKGI 365
Cdd:cd06173 242 GAAGYGLLLAAFG----VGALLGALLLGRLSKRRRR----GRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 732683370 366 GALGW-AVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGALIYVGVHALIAVLSYL 433
Cdd:cd06173 314 FNVPLnTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
57-410 |
3.15e-10 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 61.43 E-value: 3.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 57 MGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDifSGFGIIVAlftlRFLVGLAEAPSFPGNS 136
Cdd:cd17502 32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP--NMTMLIVG----RAIQGIGGGGLMSLAF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 137 RIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFMGGLGIVISFIwlkvihepnqhpgvnkkele 216
Cdd:cd17502 106 IIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALAL-------------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 217 yiaaggalinmdqqntkvkvpfsvkwgqikqllgSRMMIGVYIGQYCINALTYFFITWFPVYLVQARGMSILKAGfVASV 296
Cdd:cd17502 166 ----------------------------------LRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSG-VRLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 297 PAVCGFiggVLGGIISDWLMRRTGSLniarKTPIVMGMLLSMV----MVFCNYVNVEWMIIGFMALAFFGKGIGALGWAV 372
Cdd:cd17502 211 PLIIGL---VIGSIISGALISKTGRY----KPLIVIGTILMSVgaglLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLV 283
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 732683370 373 MA-DTAPKEISGLSGGLFNMFGNISG-IVTPIAIGYIVGT 410
Cdd:cd17502 284 AVqNAVPPADVGVATATNTFFRSLGGtLGVAITDVFLVAL 323
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
18-393 |
4.36e-10 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 61.26 E-value: 4.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 18 RYW---IVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRfgSKRVYFWSIFI 94
Cdd:PRK11663 18 RYWrrhILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDR--SNARYFMGIGL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 95 wsmftLLQGFVDIFSGFGIIVALFTLRFLV-GLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWL 173
Cdd:PRK11663 96 -----IATGIINILFGFSSSLWAFALLWVLnAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 174 THEVGWSHVFFFMGGLGIVISFIWLKVIHEPNQHPGV--------NKKELEYIAAGGALINMDQQNTKVkvpFSVKWgqI 245
Cdd:PRK11663 171 ALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLpsvgewrhDALELAQQQEGAGLSRKEILTKYV---LLNPY--I 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 246 KQLLGSRMMigVYIGQYCINaltyffiTWFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMR-RTGSLNI 324
Cdd:PRK11663 246 WLLSFSYVL--VYVVRAAIN-------DWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFNgNRGPMNL 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 732683370 325 ArktpIVMGMLLSM----VMVFCNYVnveWMIIGFMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFG 393
Cdd:PRK11663 317 I----FAAGILLSVgslwLMPFASYV---MQAACFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFA 382
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
42-366 |
4.42e-10 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 61.05 E-value: 4.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 42 AGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIfsgfgiIVALFTLR 121
Cdd:cd17323 21 ALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPN------IAMLIILR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 122 FLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFF---MGGLGIVISFIWL 198
Cdd:cd17323 95 FLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFlaiISGFCLILIFLFL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 199 KVIhepnqhpgvnkkeleyiaaggalinmdqqntkvkvpfsvkwgqikqllgsrMMIGVYIGqyCINALTYFFITWFPVY 278
Cdd:cd17323 175 PIV---------------------------------------------------LLLGLYVG--LVYAILYLFLTAFPYV 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 279 LVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMRRTGSLNI------ARKTPIVMGMLLSMVMVF----CNYVNV 348
Cdd:cd17323 202 FGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKKNGgkpepeARLPPAFIGAFLFPIGLFifgwTIYPHI 281
|
330
....*....|....*...
gi 732683370 349 EWMIIgFMALAFFGKGIG 366
Cdd:cd17323 282 HWIVP-IIGSAFFGFGLM 298
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
45-411 |
6.46e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 60.67 E-value: 6.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 45 EMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSGFGIivalftLRFLV 124
Cdd:cd17320 24 AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLI------ARFLQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 125 GL-AEAPSFPGNSrIVAAWFPAQERGTAVSIFNSAQYFATVIfAPIMG-WLTHEVGWSHVFFFMGGLGIVISFIWLKVIH 202
Cdd:cd17320 98 GLgAAAGSVVARA-IVRDLYSGAELAKIFSLLMMILAIAPAL-APLLGgLLLLFFGWRAIFVFLALLGLLLLLLVLLFLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 203 EPNQHPgvnkkeleyiaaggalinmdqqntKVKVPFSVKWGQIKQLLGSRMMIGVYIGQYCINALTYFFITWFPVYLVQA 282
Cdd:cd17320 176 ETLPEE------------------------KRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQ 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 283 RGMSILKAGFVASVPAvcgfIGGVLGGIISDWLMRRTGSLNIARK--TPIVMGMLLSMVMVFCNYVNVeWMIIGFMALAF 360
Cdd:cd17320 232 LGLSPAQFGLLFALNA----IALILGSLLNGRLVRRFGPRRLLRLglLLLLAAALVLLLAALLGGLSL-WPLVAPLFLIF 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 732683370 361 FGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTT 411
Cdd:cd17320 307 FGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGT 357
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
58-203 |
1.17e-09 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 56.50 E-value: 1.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 58 GYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSGfgiivaLFTLRFLVGLAEAPSFPGNSR 137
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITV------LIIARFLQGFGAAFALVAGAA 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 732683370 138 IVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFMGGLGIVISFIWLKVIHE 203
Cdd:TIGR00880 75 LIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
51-431 |
3.28e-09 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 58.69 E-value: 3.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 51 GLDP-VGMGYVFSAFSWAYV---IGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSGFGII--VALFTLRFLV 124
Cdd:cd17369 36 AVDPaAGTLAAFATFGVGFLarpLGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQIGILapILLVLLRLLQ 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 125 GLAEAPSFPGNSRIVAAWFPAQERGTAVSI----FNSAQYFATVIFAPIMGWLTHEV----GWSHVFFFMGGLGIVISFI 196
Cdd:cd17369 116 GLALGGEWGGAVLMAVEHAPPKRRGFYGSFpqlgAPVGLLLATGVFLLLSALLSDEAflswGWRIPFLLSAVLVAVGLYI 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 197 WLKVIHEPnqhpgvnkkelEYIAAggalinMDQQNTKVKVPFSVKWGQIKQLLGsrmMIGVYIGQyciNALTYFFITWFP 276
Cdd:cd17369 196 RLRLEETP-----------VFRRA------KEAGQVVRAPLVEVLRRHWRALLL---AIGLRLAE---NVLFYLFTTFAL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 277 VYLVQARGMS---ILKAGFVASvpaVCGFIGGVLGGIISDwlmrrtgslNIARKTPIVMGMLLSMVMVF-----CNYVNV 348
Cdd:cd17369 253 SYATQTLGVDrstVLLAVLIAS---VVAAITIPLFGWLSD---------RVGRRPVYLAGALLAALFAFpffwlLDTGST 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 349 EWMIIGFMALAFFGKGI--GALGwAVMADTAPKEI--SGLSGGlFNMFGNISGIVTPIAIGYIVGTTGSFNGALIYVGVH 424
Cdd:cd17369 321 WLIVLAAVVVLGVLHGMmyGPQA-AFLAELFPTRVryTGASLG-YQLGAILGGGFAPLIATALVAATGSWWPVALYLAAL 398
|
....*..
gi 732683370 425 ALIAVLS 431
Cdd:cd17369 399 AVISLVA 405
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
18-196 |
4.71e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 57.61 E-value: 4.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 18 RYWIVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSM 97
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 98 FTLLQGFVDIFSGFGIIVALFTLRFLVGLAEAPSFPgnsrIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEV 177
Cdd:cd17316 256 LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYA----YLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAST 331
|
170
....*....|....*....
gi 732683370 178 GWSHVFFFMGGLGIVISFI 196
Cdd:cd17316 332 GGTGVPALILALLAIVALI 350
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
3-200 |
1.20e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.81 E-value: 1.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 3 SLSQAASSVEKRTNARYWIVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLD-R 81
Cdd:cd17474 182 SSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkR 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 82 FGSKRVYFWSIFIWSMFTLLQGFVDIFSGFGIIVALFtlrflvGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYF 161
Cdd:cd17474 262 FGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLF------GLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFL 335
|
170 180 190
....*....|....*....|....*....|....*....
gi 732683370 162 ATVIFAPIMGWLTHEVGWSHVFFFMGGLGIVISFIWLKV 200
Cdd:cd17474 336 GQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
35-199 |
1.48e-08 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 56.62 E-value: 1.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 35 DRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSgfgii 114
Cdd:TIGR00711 17 DSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLE----- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 115 vALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATvIFAPIM-GWLTHEVGWSHVFFF---MGGLG 190
Cdd:TIGR00711 92 -LMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAP-ALGPTLgGWIIENYHWRWIFLInvpIGIIV 169
|
....*....
gi 732683370 191 IVISFIWLK 199
Cdd:TIGR00711 170 VVVAFFILP 178
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
15-208 |
1.50e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 56.43 E-value: 1.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 15 TNARYWIVVMLFIVTSFNYgdrATLSIAGSEMAKDI-GLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIF 93
Cdd:COG2223 203 RDPRFWLLSLLYFGTFGSF---IGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFA 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 94 IWSMFTLLQGFVDIfSGFGIIVALFTLRFLVGLAEAPSFpgnsRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWL 173
Cdd:COG2223 280 LMALGLLLLALALG-SLWLFLVLFLLLGLALGGGNGAVF----ALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL 354
|
170 180 190
....*....|....*....|....*....|....*
gi 732683370 174 THEVGWSHVFFFMGGLGIVISFIWLKVIHEPNQHP 208
Cdd:COG2223 355 LDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRA 389
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
18-435 |
3.91e-08 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 54.92 E-value: 3.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 18 RYWIVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSM 97
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 98 FTLLQGFVDifsgfGIIVALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQeRGTAVSIFNSAQYFATVIFAPIMGWLTHEV 177
Cdd:cd17353 81 GFILSAFAI-----SLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 178 GWSHVFFFMGGLGIVISFIWLKVIHEPNQHPGVNKKELEYIAAGGALINMdqqntkvkvpfsvkwgQIKQLLGSRMMIGV 257
Cdd:cd17353 155 GVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDY----------------TPREMLRTPTFWLL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 258 YIGQYCINALTYFFITWFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMRRTgSLNIArktpIVMGMLLS 337
Cdd:cd17353 219 WLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKN-TLSIA----FLIQGVAM 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 338 MVMVFCNYVNVeWMIIGFMALAFFGKGIGALGWAVMADT-APKEISGLSGGLFNMFGnISGIVTPIAIGYIVgTTGSFNG 416
Cdd:cd17353 294 FLLPFIGSVAV-LFVLGVALIGFCYGGGFALFPALTADFfGTKNAGTNYGLLYTAKG-VGGLIGPIIAAYVL-YTGGYNA 370
|
410
....*....|....*....
gi 732683370 417 ALIYVGVHALIAVLSYLVL 435
Cdd:cd17353 371 AFIIAAALSLVALALALLL 389
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
57-443 |
3.92e-08 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 55.10 E-value: 3.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 57 MGYVFSAFSWAYVIGQIPGGWLLDRfgSKRVYFWSIFIwsmftLLQGFVDIFSGF-----GIIVALFTLRFLVGLAEAPS 131
Cdd:PRK11273 65 LGFALSGISIAYGFSKFIMGSVSDR--SNPRVFLPAGL-----ILAAAVMLFMGFvpwatSSIAVMFVLLFLCGWFQGMG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 132 FPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPI----MGWLTHevgWSHVFFFMGGLGIVISFIWLKVIHEPNQH 207
Cdd:PRK11273 138 WPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPLLfllgMAWFND---WHAALYMPAFAAILVALFAFAMMRDTPQS 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 208 ---PGVNKKELEYiaaggalinMDQQNTKVKVPFSVKWGQIKQLLGSRMMIGVYIGQYCINALTYFFITWFPVYLVQARG 284
Cdd:PRK11273 215 cglPPIEEYKNDY---------PDDYNEKHEQELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKH 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 285 MSILKAGFVASVPAVCGFIGGVLGGIISDWLMRRTgslniaRKTPIVMGMLLSMVMVFCNYVN---------VEWMIIGF 355
Cdd:PRK11273 286 FALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGN------RGATGVFFMTLVTIATIVYWLNpagnptvdmACMIVIGF 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 356 MalaFFGK----GIGALgwavmaDTAPKEISGLSGGLFNMFGNISGIVTPIAI-GYIVGTTGSFNGALIYVGVHALIAVL 430
Cdd:PRK11273 360 L---IYGPvmliGLHAL------ELAPKKAAGTAAGFTGLFGYLGGSVAASAIvGYTVDFFGWDGGFMVMIGGSILAVIL 430
|
410
....*....|...
gi 732683370 431 SYLVLVGDIKRIE 443
Cdd:PRK11273 431 LIVVMIGEKRHHE 443
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
49-434 |
4.10e-08 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 55.32 E-value: 4.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 49 DIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGfvdIFSGfgiIVALFTLRFLVGLAE 128
Cdd:PRK12307 47 DLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSG---LASG---VIMLTLSRFIVGMGM 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 129 APSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFmgGLGIVISFIWLKVIHEPNQhp 208
Cdd:PRK12307 121 AGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFV--GLLPVLLVIYIRARAPESK-- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 209 gvnkkelEYIAAGGALINMDQQNTKVKVPFSVKwGQIKQLLGSRMMIgVYIGQYCINALTYFFITWFPVYLVQargmSIL 288
Cdd:PRK12307 197 -------EWEEAKLSGKGKHSQSAWSVFSLSMK-GLFNRAQFPLTLC-VFIVLFSIFGANWPIFGLLPTYLAG----EGF 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 289 KAGFVASVPAVCGFiGGVLGGIISDWLMRRTGSlniarKTPIVMGMLLSMVMVFC-------NYVNVEWMIIGFMALAFf 361
Cdd:PRK12307 264 DTGVVSNLMTAAAF-GTVLGNIVWGLCADRIGL-----KKTFSIGLLMSFLFIFPlfripqdNYLLLGACLFGLMATNV- 336
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 732683370 362 gkGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSfnGALIYVGVHALIAVLSYLV 434
Cdd:PRK12307 337 --GVGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLGITMGL--GAALTFIVAFWTATILLII 405
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
39-397 |
5.97e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 54.50 E-value: 5.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 39 LSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSgfgiivALF 118
Cdd:cd17503 15 VNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLA------SLI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 119 TLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSaqyfaTVIFAPIM-----GWLTHEVGWSHVFFFMGGLGIVi 193
Cdd:cd17503 89 IFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGL-----VILLAPAIgptlgGWLTDNLSWRWIFYINLPIGIL- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 194 sfiwlkvihepnqhpgvnkkeleyIAAGGALINmdqqntkvkvpfsVKWGQIKQL-LGSRMMIGVYIGQYCINALtyffi 272
Cdd:cd17503 163 ------------------------ALLLAPLLD-------------LRLFKDRNFtLGLLLSFLLGLGLFGAMFL----- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 273 twFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWL-MRRTGslniarkTPIVMGMLLSMVMVFCNYVNVEWM 351
Cdd:cd17503 201 --LPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFgPRLLL-------LAGLLLLALGTLLLAFLTPDTSLW 271
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 732683370 352 IIGFmALAFFGKGIGALGWAVMADTA---PKEISGLSGGLFNMFGNISG 397
Cdd:cd17503 272 LIIL-PLFIRGLGMGLVFMPLNTLALnslPPEQIGDATALFNTIRQLGG 319
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
18-434 |
1.92e-07 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 53.01 E-value: 1.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 18 RYWIVVMLFIVTSF-NYGDRATLSIAGS-----EMAKDIGLDPVGMGYVFsafswAYVIGQIPGGWLLDRFGSKrvyfWS 91
Cdd:cd17398 1 RRWIMLFLFCLYSMsNAFQWIQYAIISNiivdyYGVSDTAVDWTSMIYML-----TYIPLIFPATWLLEKYGLR----VT 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 92 IFIWSMFTLLQGFVDIFS----GFGIivaLFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSI------FNSAQYF 161
Cdd:cd17398 72 VLLGSFLNCLGAWLKLFSsspdLFWV---AMAGQTICALAQVFILGIPPRLAAVWFGPDEVSTATAIgvfgnqLGVALGF 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 162 ATVIFAPIMGWLTHEVGWSHVFFFMGGLGI-----VISFIWLKviHEPNQHPGVNKKELeyiaaggalinmdQQNTKVKV 236
Cdd:cd17398 149 VLPPLLVPNSENKDEIGKGLSILFYGVAGIctalfILVIIFFK--EKPPIPPSRAQAAA-------------QELRSEDQ 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 237 PFsvkWGQIKQLLGSRMMIGVYIgQYCINALTYFFITWF--PVYLVQARGMSILkAGFVASVPAVCGFIGGVLGGIISDW 314
Cdd:cd17398 214 SY---LGSLKRLFKNKGFLLLLI-TYGINTGVYYAISTLlnQMVLEYFPNEEVN-AGWIGLTLVIAGLVGSVVAGIWLDK 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 315 LMR-RTGSLNIARKTpiVMGMLLSMVMVFCNYVNVEWMIIGfmALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFG 393
Cdd:cd17398 289 TKKyKETTIIVYILS--FIGMVAFTFTLDLGSIWVVFLTAG--ALGFFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASA 364
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 732683370 394 NISGIVTPIAIGYIVGTTGSFNGALIYVGVHALIAVLSYLV 434
Cdd:cd17398 365 QIFGIIFTLVMGALLDKVGALASNIVLSVALLLGTILTAFI 405
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
48-430 |
1.17e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 50.25 E-value: 1.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 48 KDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDifsgfgIIVALFTLRFLVGLA 127
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD------SPWVWFLLRFVMGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 128 EAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIfAPIMGWLTHEVGWshVFFFMGGLGIVISFIWLKVIHEPnqh 207
Cdd:cd17477 98 LAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFAL-GPLLLALVGTAGA--LPFLIAAVLLLLALVPLLLTRRA--- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 208 pgvnkkeleyiaaggalinmdqqNTKVKVPFSVKWGQIKQLLGSRMMIGVYIGqycinALTYFFITWFPVYLVQArGMSI 287
Cdd:cd17477 172 -----------------------APEIEEAESISLRRLLRIAPLALLGAFVAG-----FLEGAFYSLLPLYGLRL-GLSV 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 288 LKAGFVASVPAVCGFIGGVLGGIISDWLMRRTGSLNIArktpiVMGMLLSMVMVFCNYVNVEWMIIGFMALAFFGkGIGA 367
Cdd:cd17477 223 AQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCA-----LLGALAALLLPLVPGLPLALLVLLFLWGGAAG-PLYT 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 732683370 368 LGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGALIYVGVHALIAVL 430
Cdd:cd17477 297 LALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
13-198 |
1.21e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 50.23 E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 13 KRTNARYWIVVMLFIVTSFNYGDRATLSIagseMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSI 92
Cdd:cd17370 196 KKLPKAFWLYLLAVALFALGNFSFAFLIL----RAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGY 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 93 FIWSMFTLLQGFVDIFSGFGIIVALFTLRFlvGLAEAPSfpgnSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGW 172
Cdd:cd17370 272 LSLALAYLGFALGSSLWLLLLGFILWGLYM--GAQESIE----RAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGY 345
|
170 180
....*....|....*....|....*.
gi 732683370 173 LTHEVGWSHVFFFmGGLGIVISFIWL 198
Cdd:cd17370 346 LWDLISPSAAFLF-SAVLALIALLLL 370
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
20-435 |
1.92e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 49.86 E-value: 1.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 20 WIVVML-FIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMF 98
Cdd:cd17352 2 WVVVFAsFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 99 TLLQGFVDIFSGFgiivaLFTLRFLVGLAEAPSFPGNSRIVAAWFpAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVG 178
Cdd:cd17352 82 LLLSSFATSLWQL-----YLTYGVLGGLGLGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 179 WSHVFFFMGGLGIVISFiwlkvihepnqhpgvnkkeleyiaaGGALInmdqqntkvkvpfsvkwgqikQLLGSRMMIGVY 258
Cdd:cd17352 156 WRGALLILGGLCLNLCV-------------------------CGLLL---------------------RLLKDPTFVLLA 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 259 IGQYCINALTYFFITWFPVYLVQaRGMSILKAGFVASVPAVCGFIGGVLGGIISDWlmRRTGSLNIARKTPIVMGMLLSM 338
Cdd:cd17352 190 LGVSFAMLGFFVPFVYLPSYAKS-LGIDESDAAFLLSIIGISDIVGRILLGLLADK--PRIGRLYLYIFTLLILGLSLLA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 339 VMVFCNYVNvewMIIGFMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGAL 418
Cdd:cd17352 267 FPLATTYVG---LIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAF 343
|
410
....*....|....*..
gi 732683370 419 IYVGVHALIAVLSYLVL 435
Cdd:cd17352 344 YFCGACLLLSGVLLFLL 360
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
46-435 |
2.28e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 49.50 E-value: 2.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 46 MAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSgfgiivALFTLRFLVG 125
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLP------VLIAGRALQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 126 LAeAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFMGGLGIVIsfiwlkvihepn 205
Cdd:cd17504 96 IG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLL------------ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 206 qhpgvnkkeleyiAAGGALINMDqqntkvkvpfsvkwgqikqLLGSRMMIGVYIGQYCINALTYFFITWFPVYLVQAR-- 283
Cdd:cd17504 163 -------------AALVPLIDLR-------------------LLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTpt 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 284 --GMSILKAGFVASVPAVCGFIGGVLGGiisdWLMRRTGSLNIARKTPIVMGMLLSMVMVFcnyVNVEWMIIGFMALAFF 361
Cdd:cd17504 211 gfGLGITEAGLLLLPGALVMLIAGPLAG----RLIARVGPRRVLLIGLVISAVGLLLLALL---HSSLWALVVALLLIGI 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 362 GKGIGALGWA-VMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYI------------VGTTGSFNGALIYVGVHALIA 428
Cdd:cd17504 284 GLGLAFASLPnIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIlttytvsitsggVPTEGAYVLAFLIGAALALAA 363
|
....*..
gi 732683370 429 VLSYLVL 435
Cdd:cd17504 364 LLLSLLI 370
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
70-435 |
2.89e-06 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 49.29 E-value: 2.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 70 IGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSGFGIIVALFTL--RFLVGLAEAPSFPGNSRIVAAWFPAQE 147
Cdd:cd17368 55 IGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYATIGIAAPLLVLlaRLLQGFAAGGEVGGVTAYLVEAAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 148 RGTAVSIFNSAQYFATViFAPIMG-----WLTHEV----GWsHVFFFMGGLGIVISFIWLKVIHEPNQHPGvNKKELEYI 218
Cdd:cd17368 135 RGFYTSWQSASQQVAIV-AGALVGyllslTLTAEAlaewGW-RIPFFIGLLIIPLGLWLRRSLEETEAFLE-RKARPTRR 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 219 AAGGALINmdqqntkvkvpfsvKWGQIkqLLGSRMMIGVYIGQYCINALTyffitwfPVYLVQARGMSILKAGFVASVPA 298
Cdd:cd17368 212 ELFALLAN--------------NRRII--LLGMLLVAGSTVTFYFTTVYT-------PTYAKTVLGLSARDSFLVTLLAG 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 299 VCGFIGGVLGGIISDwlmrrtgslNIARKTPIVMGMLLSMVMVF------CNYVNVEWMIIGFMALAFFGKGIGALGWAV 372
Cdd:cd17368 269 VANFIWAPLGGALSD---------RIGRRPVLLVITLAALVTLYpvfawlTAAPSFGRLLLVLLVLSFFFGMYGGAMVVA 339
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 732683370 373 MADTAPKEISGLSGGLFNMFG-NISGIVTPIAIGYIVGTTGSFNGALIYVGVHALIAVLSYLVL 435
Cdd:cd17368 340 LVELFPVRVRSTGFSLVYALAvAIFGGFAQFIVTWLIELTGSPLAPAWYLMGAALLGLLATLML 403
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
257-435 |
1.16e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.03 E-value: 1.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 257 VYIGQYCINALTYFFITWFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDwlmrrtgslNIARKTPIVMGMLL 336
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD---------RFGRRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 337 SMVMVFC--NYVNVEWMIIGFMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSF 414
Cdd:pfam07690 72 FALGLLLllFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR 151
|
170 180
....*....|....*....|.
gi 732683370 415 NGALIYVGVHALIAVLSYLVL 435
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLPR 172
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
259-409 |
3.18e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.07 E-value: 3.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 259 IGQYCINALTYFFITWFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDwlmrrtgslNIARKTPIVMGMLLSM 338
Cdd:cd17329 6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLAD---------RFGRKPVMLAGLLLRA 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 732683370 339 VM-VFCNYVNVEWMIIGFMALAFFGKG-IGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVG 409
Cdd:cd17329 77 LGfALLGFAHSPWLFAIALVLTGFGGGlFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL 149
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
58-184 |
3.46e-05 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 45.82 E-value: 3.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 58 GYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMftllqGFVDIFSGFGIIVALFTLRfLVGLAEAPSFPGNSR 137
Cdd:PRK12382 252 GFTLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETV-----GLLLLWLAPTAWVALAGAA-LTGAGCSLIFPALGV 325
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 732683370 138 IVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFF 184
Cdd:PRK12382 326 EVVKRVPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFL 372
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
252-435 |
3.90e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.74 E-value: 3.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 252 RMMIGVYIGQYCINALTYFFITWFPvYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWlmrrtgslnIARKTPIV 331
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR---------FGRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 332 MGMLLSMVMVFCNYV--NVEWMIIGFMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVG 409
Cdd:COG2814 80 LGLLLFALGSLLCALapSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180
....*....|....*....|....*.
gi 732683370 410 TTGSFNGALIYVGVHALIAVLSYLVL 435
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
35-433 |
4.77e-05 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 45.25 E-value: 4.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 35 DRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSGFgiI 114
Cdd:cd17359 16 DTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIF--I 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 115 VALFTLRFLVGLAeapsfpgnSRIVAAWF----PAQERGTAVSIFN----SAQYFATVIFAPIMGWLTHEVGWSHVFFFM 186
Cdd:cd17359 94 IARIIGGLAVGGA--------SALVPMYIaevaPAEIRGRLVSLNQlmivFGQLLAYIVNYLIANAGGADWLGAEGWRWM 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 187 GGLGIVISFIWLKVIhepnqhpgvnkkeleyiaaggalinmdqqntkVKVPFSVKW--GQIKQLLGSRMMIGVyIGQYC- 263
Cdd:cd17359 166 LGLEAIPAILFLLGM--------------------------------LFIPESPRWlvSKGKPILIIGIGLAI-FQQFVg 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 264 INALTYFFITWFpvylvQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMRRT----GSLniarktpivmGMLLSM- 338
Cdd:cd17359 213 INVIFYYGPEIF-----QNAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPllliGSI----------GMAISLl 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 339 VMVFCNYVNVEWMIIGFMAL-------AFFGKGIGALGWAVMADTAPKEISGLSGGL---FNMFGN-ISGIVTPIAIGYI 407
Cdd:cd17359 278 LIGTAFYFAPGSQASGIVALvlillfvAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIavfFLWIANfLVSLTFPILLAAF 357
|
410 420
....*....|....*....|....*.
gi 732683370 408 vGTTGSFngaliyvGVHALIAVLSYL 433
Cdd:cd17359 358 -GLAFTF-------LIFAVICVLAFL 375
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
46-198 |
5.18e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 45.23 E-value: 5.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 46 MAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRvyfwsIFIWSMFTLLQGFVDIFSGFGIIVALFTLrFLVG 125
Cdd:cd17324 225 LTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRA-----LLIALLLLAAALLLLTLLGPSPLLLLVGL-VLWG 298
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 732683370 126 LAEAPSFPGNSRIVAAWFPAQeRGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFMGGLGIVISFIWL 198
Cdd:cd17324 299 LGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-167 |
6.03e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.10 E-value: 6.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 14 RTNARYWIVVMLFIVTSFNYGdratLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIF 93
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFG----LLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALL 273
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 732683370 94 IWSMFTLLQGFVDIFSGFGIIVALFtlrFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFA 167
Cdd:pfam07690 274 LLILAALGLLLLSLTLSSLWLLLAL---LLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
51-171 |
6.31e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.86 E-value: 6.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 51 GLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSGFGIIVALFtlrFLVGLAEAP 130
Cdd:cd17321 200 GYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGL---VLLGLGLGL 276
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 732683370 131 SFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMG 171
Cdd:cd17321 277 FATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLG 317
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
44-383 |
1.30e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 44.30 E-value: 1.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 44 SEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSgfgiivALFTLRFL 123
Cdd:PRK03893 44 TEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYW------TLFIARLV 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 124 VGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWsHVFFFMGGLGIVISFIWLKVIHE 203
Cdd:PRK03893 118 IGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGW-RALFFIGILPIIFALWLRKNLPE 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 204 P--------NQHPGVNKKELEY------------IAAGGALI---NMDQQNTKVKVPFSVKWGQI-----KQLLGSRMMI 255
Cdd:PRK03893 197 AedwkekhaGKAPVRTMVDILYrgehriinilltLAAAAALWfcfAGNLQNAAIVAVLGLLCAAIfisfmVQSSGKRWPT 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 256 GVYIgqyCINALTYFFITW-----FPVYLVQARGMSilkAGFVASVPAVCGF---IGGVLGGIISDWL-MRRTgslniar 326
Cdd:PRK03893 277 GVML---MVVVLFAFLYSWpiqalLPTYLKTDLGYD---PHTVANVLFFSGFgaaVGCCVGGFLGDWLgTRKA------- 343
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 732683370 327 ktpIVMGMLLSMVMVFCNYV----NVEWMIIGFMALAFFGKGIGALgwavmadtAPKEISG 383
Cdd:PRK03893 344 ---YVCSLLISQLLIIPVFAiggaNVWVLGLLLFFQQMLGQGISGL--------LPKLIGG 393
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
43-200 |
1.64e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 43.79 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 43 GSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWS-------IFIWSMFTLLQGFVDIFSgFGIIV 115
Cdd:cd17357 281 STFIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISlsvcavaLLLMSVFLFLSEQNSWMS-YGCIV 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 116 A--LFTLRFLVGLAEAPSFpgnsrIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFMGGLGIVI 193
Cdd:cd17357 360 AifLFIFFFAIGLGPIPWF-----IGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGFVFIIFAIPCALFL 434
|
....*..
gi 732683370 194 SFIWLKV 200
Cdd:cd17357 435 LYLYRYL 441
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
59-198 |
1.66e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 43.34 E-value: 1.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 59 YVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSGFGIivalftLRFLVGLAEAPSFPGNSRI 138
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLV------LRFLVGVTSAGIFTVGFVL 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 139 VAAWFPAQERgTAVSIFNSAQYFATVIFAPIMGWLTHEvgWSHVFFFMGGLGIVISFIWL 198
Cdd:cd17317 103 GMEIVGPKYR-SFVGILFGLFWALGYMLLALLAYLIRD--WRWLQLAISLPGLLFLLLLW 159
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
21-436 |
1.66e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.76 E-value: 1.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 21 IVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTL 100
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 101 LQGFvdiFSGFGIIVALFtlrFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLtheVGWS 180
Cdd:cd17329 81 LLGF---AHSPWLFAIAL---VLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL---LLYS 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 181 HVFFFM-GGLGIVISFIWLKVIHEPNQHPGVNKKELEYIAAggalinmdqqntkvkvpfsvkwgqIKQLLGSRMMIGVYI 259
Cdd:cd17329 152 FRLLFLaAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRG------------------------YKIVLRDRAFLLFLL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 260 GQYCINALTYFFITWFPVYLVQArgmsilkAGFVASVPAVCGFIGGVLGGIISDWLMRRTGSLNiaRKTPIVMGMLLSMV 339
Cdd:cd17329 208 ASFLISLIYFQLESTLPVYVVEI-------LGLGESLLGLLLALNALLIVLLQFPVARLVERFR--LRKILMIGILLFAI 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 340 -MVFCNYVNVEWMIIGFMALAFFGKGIGALGW-AVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVgTTGSFNGA 417
Cdd:cd17329 279 gFAVLAFANTLAVLILAMIVLTLGEMLVFPAVqTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLL-DLLGPGLP 357
|
410
....*....|....*....
gi 732683370 418 LIYVGVHALIAVLSYLVLV 436
Cdd:cd17329 358 WLILAALGLIAAALLLGLQ 376
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
37-198 |
1.86e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 43.33 E-value: 1.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 37 ATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQgFVDIFSGFGIIVA 116
Cdd:cd17320 219 AYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVL-LLAALLGGLSLWP 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 117 LFTLRFLVGLAEAPSFPGNSRIVAAWFPaQERGTAVSIFNSAQYFATVIFAPIMGWLtHEVGWSHVFFFMGGLGIVISFI 196
Cdd:cd17320 298 LVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTASALLGFLQFLIGALAGALVGLL-PNGTALPMGLLILVLGLLALLL 375
|
..
gi 732683370 197 WL 198
Cdd:cd17320 376 LI 377
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
57-318 |
3.92e-04 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 42.69 E-value: 3.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 57 MGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQG---FVDIFS-GFGIIVALFTlrflvGLAEAPSF 132
Cdd:cd17344 64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGlgyYWNIHSlWYFVVVQILA-----GLFQSTGW 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 133 PGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMG-WLTHEVGWSHVF--FFMGGLGIVisfIWLKVIHEPnqhPG 209
Cdd:cd17344 139 PSVVACVGNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGiFVSSAWGLSFIVpgIIIAAMGVL---VFLFLVEHP---PG 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 210 VnkkeleyiaaggalinmdqqntkvkVPFSVkwgqikQLLGSRMmigvyigqycinaLTYFFITWFPVYLVQARGMSILK 289
Cdd:cd17344 213 V-------------------------IEFSL------CLFFAKL-------------VSYTFLYWLPLYISNTAILSAKK 248
|
250 260
....*....|....*....|....*....
gi 732683370 290 AGFVASVPAVCGFIGGVLGGIISDWLMRR 318
Cdd:cd17344 249 AGDLSTLFDVGGIVGGILAGYISDYTGGR 277
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
47-197 |
4.18e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.16 E-value: 4.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 47 AKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSgfgiiVALFTLRFLVGL 126
Cdd:cd17477 215 GLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLP-----LALLVLLFLWGG 289
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 732683370 127 AEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFMGGLGIVISFIW 197
Cdd:cd17477 290 AAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
60-164 |
6.18e-04 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 41.88 E-value: 6.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 60 VFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSGFGIIVALFTLRFLVGLAEAPSFPGNSRIV 139
Cdd:cd17364 44 VNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLGVMGWLIFFRFLLGIGIGGDYPLSATIM 123
|
90 100
....*....|....*....|....*
gi 732683370 140 AAWFPAQERGTAVSIFNSAQYFATV 164
Cdd:cd17364 124 SEYANKKRRGALIAAVFAMQGFGIL 148
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
20-429 |
6.67e-04 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 41.63 E-value: 6.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 20 WIVVMLFIVTSF-NYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMF 98
Cdd:cd17314 2 WFVLYVSFLLSAmSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 99 TLLQGFVdifsgFGIIVALFTLRFLVGLAEAPSFPGNSRIVAAWFPaQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVG 178
Cdd:cd17314 82 YTYLSYV-----FNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLGSPLLRILWVFYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 179 WSHVFFFMGGL-GIVISFIWLKVIHEPNQHPGVNKKELEYIAAGGALINMDQqntkvkvpFSVKWGQIKQLLGSRMMIGV 257
Cdd:cd17314 156 LALVYTILGILaAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKV--------FWILFIAIFLVLIGGFLFIA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 258 YIGQYcinaltyffitwfpvylvqARGMSILKAGFVA---SVPAVCGFIGGVLGGIISDWLMRRTGSLniarktPIVMG- 333
Cdd:cd17314 228 NMASL-------------------VRSLQLDAPSFVTklmSIYGLFNAFGRLLWGIVADFFGGRLSTL------SILLTi 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 334 MLLSMVMVFCNYVNVEWMIIGFMALAFFG-KGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTG 412
Cdd:cd17314 283 LGLGLCAFLFLLKMTPVGLVLTGSLLGFSyGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTP 362
|
410
....*....|....*..
gi 732683370 413 SFNGALIYVGVHALIAV 429
Cdd:cd17314 363 SYISAVYIYAVIVFLAS 379
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
277-423 |
1.04e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 41.29 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 277 VYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDwlmrRTGSlniarKTPIVMGMLLSMVMVFCNYV---NVEWMII 353
Cdd:COG2270 263 IYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDD----RIGP-----KRVILVSLVIWIVVCLAAYFlttALAFWIL 333
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 354 GFMALAFFGkGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGALIYVGV 423
Cdd:COG2270 334 GLLIGLVMG-GIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLIV 402
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
21-198 |
2.11e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 40.25 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 21 IVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIP-GGWLLDRFGSKRVYFWSIFIWSMFT 99
Cdd:cd17330 176 LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 100 LLQGFVDIFSGFGIIVALFtlrflvGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGw 179
Cdd:cd17330 256 LLLPFASSVPLLVLAAAIL------AFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLG- 328
|
170
....*....|....*....
gi 732683370 180 SHVFFFMGGLGIVISFIWL 198
Cdd:cd17330 329 PGVPFLLAAGLLLIALFLL 347
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
14-216 |
2.12e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.27 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 14 RTNARYWIVVMLFIVTSFNYGdrATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIF 93
Cdd:COG2211 225 LKNRPFLLLLLAYLLFFLALA--LVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 94 IWSMFTLLQGFVdifsGFGIIVALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQE-------RGTAVSIFNSAQYFATVIF 166
Cdd:COG2211 303 LAALGLLLLFFL----GPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALA 378
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 732683370 167 APIMGWLTHEVGWS--------------HVFFFMGGLGIVISFIWLKVIHEPNQHPGVNKKELE 216
Cdd:COG2211 379 GALAGLLLALFGYVagaaqspsaltgirLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELA 442
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
257-430 |
3.80e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 3.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 257 VYIGQYCINALTYFFITwFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDwlmrRTGSLNIArktPIVMGMLL 336
Cdd:cd17370 204 LYLLAVALFALGNFSFA-FLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSD----RIGRKKLL---ILGYLSLA 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 337 SMVMVFCNYVNVEWMIIGFmalAFFGKGIGA---LGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVgTTGS 413
Cdd:cd17370 276 LAYLGFALGSSLWLLLLGF---ILWGLYMGAqesIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLW-DLIS 351
|
170
....*....|....*..
gi 732683370 414 FNGALIYVGVHALIAVL 430
Cdd:cd17370 352 PSAAFLFSAVLALIALL 368
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
55-436 |
3.96e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.56 E-value: 3.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 55 VGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSGFGIivaLFTLRFLVGLAEAPSFPG 134
Cdd:pfam00083 46 VLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQ---LIVGRVLVGIGVGGASVL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 135 NSRIVAAWFPAQERGTAVSIFNSAQYFATvIFAPIMGWLT----HEVGWsHVFFFMGGLGIVISFIWL------------ 198
Cdd:pfam00083 123 APMYISEIAPKKLRGALGSLYQLAITFGI-LLAYIFGLGLnktsNSDGW-RIPLGLQLVPALLLIIGLlflpesprwlve 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 199 --------KVIHEPNQHPGVNKKELEYIAAGGAliNMDQQNTKVKVPFSVKWGQIKQLLGSRMMIGvyiGQYC-INALTY 269
Cdd:pfam00083 201 kgrleearEVLAKLRGVPDVDRELDEIKDSLEA--GQEAEKASWKELFSTKTRRQRLLIGVMLQIF---QQLTgINAIFY 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 270 ffitwFPVYLVQARGMSilkAGFVASVPAVCGFIGGVLGGI-ISDWLMRRTGSLNIArktPIVMGMLLSMVMVFCNYVN- 347
Cdd:pfam00083 276 -----YSTTIFENLGLS---DSFLVTIIVGVVNFVFTFIAIfLVDRFGRRPLLLLGA---AGMAICFVILGIVALLGVSk 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 348 VEWMIIGFMA-----LAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGALIYVG 422
Cdd:pfam00083 345 SDWAGIVAIVfialfIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAG 424
|
410
....*....|....
gi 732683370 423 VHALIAVLSYLVLV 436
Cdd:pfam00083 425 LLVLFIIFVFFFVP 438
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
38-436 |
5.23e-03 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 38.87 E-value: 5.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 38 TLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFtllqgFVDIFSGFGIIVAl 117
Cdd:cd17396 18 ILAQNMSSLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALF-----FVGILFSPNLIIA- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 118 FTLRFLVGLAeapsfpgNSRIVAAWFPA------QERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFMGGLGI 191
Cdd:cd17396 92 YVFALLAGAA-------NSFLDTGTYPAlmeafpKASGSANILVKAFVSFGQFLLPFIIAFLAANNLWYGWSFIVPAAVL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 192 VISFIWLKVIHEPNQHpgvnkkeleyiaAGGALINMDQQNTKVKVPFSVKWGQIKQLLGsrmmigvyigqYCINALTYFF 271
Cdd:cd17396 165 VLNALLLLKLSFPPQT------------VTAANTKQKEIPVKREKPKFLIEGIALILIG-----------FTSTATFYLF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 272 ITWFPVYLVQARGMSILKAGFVASVPAvcgfIGGVLGGIISDWLMRRTgslnIARKTPIVMGMLLSMVMVFCNYVN---V 348
Cdd:cd17396 222 SQWMPKYGSAVAGMGEAESLKLISYYS----MGSLVCVFITAVLLKRY----VRPIWILVLYPIISLLALFVLYLVpspD 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 349 EWMIIGFMALAFFGKGIGALGWAVMADTAPKEiSGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGALIYVGVhALIA 428
Cdd:cd17396 294 VCILGAFVIGFFAAGGVLQLGLTLMAEFFPKG-KGKVTGIYMIASSLANFVIPLITGIIASAIGIAYIFLFDFGI-ALLG 371
|
....*...
gi 732683370 429 VLSYLVLV 436
Cdd:cd17396 372 LLLAIFVF 379
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
25-214 |
7.88e-03 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 38.49 E-value: 7.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 25 LFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGF 104
Cdd:PRK09556 34 VFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 105 vdIFSGFGIIVALFTLRF-LVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHV- 182
Cdd:PRK09556 114 --SLGSGSVSLGLMIALWaLSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYFFDGHVi 191
|
170 180 190
....*....|....*....|....*....|....
gi 732683370 183 --FFFMGGLGIVISFIWLKVIHEPNQHPGVNKKE 214
Cdd:PRK09556 192 gmFIFPSIIALIIGFIGLRYGSDSPEELGWGKAE 225
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
46-435 |
8.28e-03 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 38.37 E-value: 8.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 46 MAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSGFGIIValftlrFLVG 125
Cdd:PRK03699 33 IAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFGFALMILAVAGLMFSHSLALFSIAM------FVLG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 126 LAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGW-LTHEVGWSHVFFFMGGLGIVISFIWLKvihep 204
Cdd:PRK03699 107 VVSGITMSIGTFLITHVYEGKQRGSRLLFTDSFFSMAGMIFPIIAAYlLARSIEWYWVYACIGLVYVAIFILTLF----- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 205 nqhpgvnkkeLEYIAAGGALINMDQQNTKVKVPFSVKWGQIKQLLGsrmMIGVYIgqycinaltyfFITWFPVYLVQARG 284
Cdd:PRK03699 182 ----------SEFPALGKHAPKADKPVAKEKWGIGVLFLAIAALLY---ILAQLT-----------FISWVPEYAQKKFG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 285 MSILKAGFVASVpavcGFIGGVLGGIISDWLMRRtgsLNIARKTPIVMGMLLSMVMVFCNYVNVEWMIIGFMALAFFG-- 362
Cdd:PRK03699 238 MSLEDAGNLVSN----FWMAYMVGMWIFSFIVRF---FDLQRILTVLAGLALVLMYLFVNTDDPSHLLYAILGLGFFSsa 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 732683370 363 --KGIGALGWAVMADTAPKEISGLSgglfnMFGNISGIVTPIAIGYIVGTTGSFNGALIYVGVHALIAVLSYLVL 435
Cdd:PRK03699 311 iyTTIITLGSQQTKVASPKLVNFIL-----TCGTIGTMLTFVVTSPIVAHFGLQAALLTANGLYAVVFVMCILLG 380
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
48-195 |
9.21e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.31 E-value: 9.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732683370 48 KDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVdifSGFGIIVALftlrFLVGLA 127
Cdd:cd17478 223 VQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLT---PGIWSYILL----VLAGFL 295
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 732683370 128 EAPSFPGNSRIVAAWFPaQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFF---FMGGLGIVISF 195
Cdd:cd17478 296 LFASFPVTVVLAQELLP-GNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLilaLLPLLGALLAF 365
|
|
| |
