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Conserved domains on  [gi|732685956|gb|AIZ92761|]
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3-isopropylmalate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

3-isopropylmalate dehydrogenase( domain architecture ID 10011514)

3-isopropylmalate dehydrogenase catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate

CATH:  3.40.718.10
EC:  1.1.1.85
Gene Symbol:  leuB
Gene Ontology:  GO:0003862|GO:0046872|GO:0051287
SCOP:  4000791

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 3-362 0e+00

3-isopropylmalate dehydrogenase; Provisional


:

Pssm-ID: 234832  Cd Length: 358  Bit Score: 698.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWE 82
Cdd:PRK00772   1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  83 HLPPDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAAnGFDILCVRELTGGIYFGQPKGREGSGQYEKAF 162
Cdd:PRK00772  81 NLPPDVRPERG-LLALRKELGLFANLRPAKLYPGLADASPLKPEIVA-GLDILIVRELTGGIYFGEPRGREGLGGEERAF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 163 DTEVYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242
Cdd:PRK00772 159 DTMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAI 322
Cdd:PRK00772 239 IVTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAI 318

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 732685956 323 ERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAEG 362
Cdd:PRK00772 319 EAAVEKVLAQGYRTADIAEGGGKVSTSEMGDAILAALAEG 358
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 3-362 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 698.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWE 82
Cdd:PRK00772   1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  83 HLPPDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAAnGFDILCVRELTGGIYFGQPKGREGSGQYEKAF 162
Cdd:PRK00772  81 NLPPDVRPERG-LLALRKELGLFANLRPAKLYPGLADASPLKPEIVA-GLDILIVRELTGGIYFGEPRGREGLGGEERAF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 163 DTEVYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242
Cdd:PRK00772 159 DTMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAI 322
Cdd:PRK00772 239 IVTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAI 318

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 732685956 323 ERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAEG 362
Cdd:PRK00772 319 EAAVEKVLAQGYRTADIAEGGGKVSTSEMGDAILAALAEG 358
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 6-355 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 632.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956    6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEHLP 85
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   86 PDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAaNGFDILCVRELTGGIYFGQPKGREGSGqyeKAFDTE 165
Cdd:TIGR00169  81 RDQRPEQG-LLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIA-KGVDFVVVRELTGGIYFGEPKGREGEG---EAWDTE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  166 VYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLC 245
Cdd:TIGR00169 156 VYTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  246 SNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERA 325
Cdd:TIGR00169 236 SNLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAA 315

                         330       340       350
                  ....*....|....*....|....*....|.
gi 732685956  326 INRALEEGIRTGDLARGA-AAVSTDEMGDII 355
Cdd:TIGR00169 316 VKKVLAEGYRTPDLGSSAtTAVGTAEMGEEL 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 4-359 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 575.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWeh 83
Cdd:COG0473    1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKW-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  84 lPPDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEafCPLRADIAAnGFDILCVRELTGGIYFGQPKGREGSGQYEKAFD 163
Cdd:COG0473   79 -DDGVRPESG-LLALRKELDLYANLRPAKLYPGLP--SPLKPEIVE-GIDLVIVRENTEGLYFGIGGRIGTGTGEEVAID 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 164 TEVYHRFEIERIARIAFESARKRRHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242
Cdd:COG0473  154 TRVYTRKGIERIARYAFELARKRRKKVTSVDKANVLkLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADDAACAI 322
Cdd:COG0473  234 IVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH-LGEEEAADAI 312

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 732685956 323 ERAINRALEEGIRTGDLargAAAVSTDEMGDIIARYV 359
Cdd:COG0473  313 EAAVEKVLAEGVRTPDL---GGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
6-355 0e+00

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 550.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956    6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEhlP 85
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--P 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   86 PDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAanGFDILCVRELTGGIYFGQPKGREGSGQyEKAFDTE 165
Cdd:pfam00180  79 AGVRPENG-LLALRKELGLFANLRPAKVFPPLGDASPLKNEVE--GVDIVIVRELTGGIYFGIEKGIKGSGN-EVAVDTK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  166 VYHRFEIERIARIAFESARKR-RHKVTSIDKANVLQSSILWREIVNEIAT-EYPDVELAHMYIDNATMQLIKDPSQFDVL 243
Cdd:pfam00180 155 LYSRDEIERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRKIVTEVAKaEYPDVELEHQLVDNAAMQLVKNPSQFDVI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIE 323
Cdd:pfam00180 235 VTPNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIE 314

                         330       340       350
                  ....*....|....*....|....*....|..
gi 732685956  324 RAINRALEEGIRTGDLARGAAAVSTDEMGDII 355
Cdd:pfam00180 315 AAVLKVLESGIRTGDLAGSATYVSTSEFGEAV 346
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 3-362 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 698.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWE 82
Cdd:PRK00772   1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  83 HLPPDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAAnGFDILCVRELTGGIYFGQPKGREGSGQYEKAF 162
Cdd:PRK00772  81 NLPPDVRPERG-LLALRKELGLFANLRPAKLYPGLADASPLKPEIVA-GLDILIVRELTGGIYFGEPRGREGLGGEERAF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 163 DTEVYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242
Cdd:PRK00772 159 DTMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAI 322
Cdd:PRK00772 239 IVTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAI 318

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 732685956 323 ERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAEG 362
Cdd:PRK00772 319 EAAVEKVLAQGYRTADIAEGGGKVSTSEMGDAILAALAEG 358
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 6-355 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 632.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956    6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEHLP 85
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   86 PDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAaNGFDILCVRELTGGIYFGQPKGREGSGqyeKAFDTE 165
Cdd:TIGR00169  81 RDQRPEQG-LLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIA-KGVDFVVVRELTGGIYFGEPKGREGEG---EAWDTE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  166 VYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLC 245
Cdd:TIGR00169 156 VYTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  246 SNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERA 325
Cdd:TIGR00169 236 SNLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAA 315

                         330       340       350
                  ....*....|....*....|....*....|.
gi 732685956  326 INRALEEGIRTGDLARGA-AAVSTDEMGDII 355
Cdd:TIGR00169 316 VKKVLAEGYRTPDLGSSAtTAVGTAEMGEEL 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 4-359 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 575.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWeh 83
Cdd:COG0473    1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKW-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  84 lPPDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEafCPLRADIAAnGFDILCVRELTGGIYFGQPKGREGSGQYEKAFD 163
Cdd:COG0473   79 -DDGVRPESG-LLALRKELDLYANLRPAKLYPGLP--SPLKPEIVE-GIDLVIVRENTEGLYFGIGGRIGTGTGEEVAID 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 164 TEVYHRFEIERIARIAFESARKRRHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242
Cdd:COG0473  154 TRVYTRKGIERIARYAFELARKRRKKVTSVDKANVLkLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADDAACAI 322
Cdd:COG0473  234 IVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH-LGEEEAADAI 312

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 732685956 323 ERAINRALEEGIRTGDLargAAAVSTDEMGDIIARYV 359
Cdd:COG0473  313 EAAVEKVLAEGVRTPDL---GGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
6-355 0e+00

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 550.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956    6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEhlP 85
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--P 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   86 PDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAanGFDILCVRELTGGIYFGQPKGREGSGQyEKAFDTE 165
Cdd:pfam00180  79 AGVRPENG-LLALRKELGLFANLRPAKVFPPLGDASPLKNEVE--GVDIVIVRELTGGIYFGIEKGIKGSGN-EVAVDTK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  166 VYHRFEIERIARIAFESARKR-RHKVTSIDKANVLQSSILWREIVNEIAT-EYPDVELAHMYIDNATMQLIKDPSQFDVL 243
Cdd:pfam00180 155 LYSRDEIERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRKIVTEVAKaEYPDVELEHQLVDNAAMQLVKNPSQFDVI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIE 323
Cdd:pfam00180 235 VTPNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIE 314

                         330       340       350
                  ....*....|....*....|....*....|..
gi 732685956  324 RAINRALEEGIRTGDLARGAAAVSTDEMGDII 355
Cdd:pfam00180 315 AAVLKVLESGIRTGDLAGSATYVSTSEFGEAV 346
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 3-363 2.45e-119

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 351.30  E-value: 2.45e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWE 82
Cdd:PLN02329  45 KRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWD 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  83 HLPPDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAaNGFDILCVRELTGGIYFGQPKG-REGSGQYEKA 161
Cdd:PLN02329 125 KNEKHLRPEMA-LFYLRRDLKVFANLRPATVLPQLVDASTLKKEVA-EGVDMMIVRELTGGIYFGEPRGiTINENGEEVG 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 162 FDTEVYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241
Cdd:PLN02329 203 VSTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFD 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACA 321
Cdd:PLN02329 283 TIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKR 362

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 732685956 322 IERAINRALEEGIRTGDL-ARGAAAVSTDEMGDIIARYVAEGV 363
Cdd:PLN02329 363 IEDAVVDALNKGFRTGDIySPGNKLVGCKEMGEEVLKSVDSKV 405
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 1-359 5.93e-105

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 312.25  E-value: 5.93e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRfAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPK 80
Cdd:PRK03437   1 MAKTMKLAVIPGDGIGPEVVAEALKVLDAVAAG-GPGVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGDPS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  81 wehLPPDQQpERGALLPLRKHFKLFSNLRPAKLYQGLEafCPLradiAANG-FDILCVRELTGGIYFGQpkG---REGSG 156
Cdd:PRK03437  80 ---VPSGVL-ERGLLLKLRFALDHYVNLRPSKLYPGVT--SPL----AGPGdIDFVVVREGTEGPYTGN--GgalRVGTP 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 157 QyEKAFDTEVYHRFEIERIARIAFESARKR-RHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQLI 234
Cdd:PRK03437 148 H-EVATEVSVNTAFGVERVVRDAFERAQKRpRKHLTLVHKTNVLtFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMV 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 235 KDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG--LYEPAGGSAPDIAGKNIANPIAQILSLALLLRYs 312
Cdd:PRK03437 227 TDPSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNINPTGTNpsMFEPVHGSAPDIAGQGIADPTAAILSVALLLDH- 305

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 732685956 313 LDADDAACAIERAINRALEEgirtgdlaRGAAAVSTDEMGDIIARYV 359
Cdd:PRK03437 306 LGEEDAAARIEAAVEADLAE--------RGKMGRSTAEVGDRIAARL 344
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 3-356 3.06e-92

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 279.80  E-value: 3.06e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956    3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKw 81
Cdd:TIGR02089   2 KQYRIAAIPGDGIGKEVVAAALQVLEAAAKRHGgFSLHFTEFPWSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPA- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   82 ehLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAfcPLRADiAANGFDILCVRELTGGIYFGQpKGREGSG-QYEK 160
Cdd:TIGR02089  81 --LVPDHISLWGLLLKIRREFDQYANVRPAKLLPGVTS--PLRNC-GPGDFDFVVVRENSEGEYSGV-GGRIHRGtDEEV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  161 AFDTEVYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239
Cdd:TIGR02089 155 ATQNAIFTRKGVERIMRFAFELAQKRRKHLTSATKSNGIRHSMpFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPET 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGF--GLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADD 317
Cdd:TIGR02089 235 FDVIVASNLFGDILSDLGAALMGSLGVAPSANINPEGKfpSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEH-LGEKE 313

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 732685956  318 AACAIERAINRALEEGIRTGDLARGAaavSTDEMGDIIA 356
Cdd:TIGR02089 314 AGAKIMDAIERVTAAGILTPDVGGKA---TTSEVTEAVC 349
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 5-359 8.00e-85

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 260.07  E-value: 8.00e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMrittSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGgpkweHL 84
Cdd:PRK14025   2 HKICVIEGDGIGKEVVPAALHVLEATGLPFEF----VYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAG-----ET 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  85 PPDqqpergALLPLRKHFKLFSNLRPAKLYQGLEAFCPlradiaanGFDILCVRELTGGIYfgqpKGREGSGQYEKAFDT 164
Cdd:PRK14025  73 AAD------VIVKLRRILDTYANVRPVKSYKGVKCLYP--------DIDYVIVRENTEGLY----KGIEAEIADGVTVAT 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 165 EVYHRFEIERIARIAFESARKR-----RHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238
Cdd:PRK14025 135 RVITRKASERIFRFAFEMAKRRkkmgkEGKVTCAHKANVLKKTDgLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQ 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQgFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADDA 318
Cdd:PRK14025 215 TFDVVVTSNLFGDILSDGAAGLVGGLGLAPSANIGDK-YGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRH-LGENEE 292

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 732685956 319 ACAIERAINRALEEGIRTGDLargAAAVSTDEMGDIIARYV 359
Cdd:PRK14025 293 ADKVEKALEEVLALGLTTPDL---GGNLSTMEMAEEVAKRV 330
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 3-357 1.41e-83

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 257.73  E-value: 1.41e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   3 KNYHIAVLPGDGIGPEVMTQALKVLDAV-RNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKw 81
Cdd:PRK08194   2 KQFKIAVIPGDGVGKEVVPAAVRVLKAVaEVHGGLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPK- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  82 ehLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAfcPLRAdiaANGFDILCVRELTGGIYfGQPKGREGSGQYEKA 161
Cdd:PRK08194  81 --LVPDHISLWGLLIKIRREFEQVINIRPAKQLRGIKS--PLAN---PKDFDLLVVRENSEGEY-SEVGGRIHRGEDEIA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 162 FDTEVYHRFEIERIARIAFESARKRRHKVTSIDKAN-VLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240
Cdd:PRK08194 153 IQNAVFTRKGTERAMRYAFELAAKRRKHVTSATKSNgIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRPEEF 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGF--GLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADDA 318
Cdd:PRK08194 233 DVIVASNLFGDILTDIGAAIMGSIGIAPAANINVNGKypSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDH-FGEEEL 311

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 732685956 319 ACAIERAINRALEEGIRTGDLArGAAavSTDEMGD-IIAR 357
Cdd:PRK08194 312 GSHLLDVIEDVTEDGIKTPDIG-GRA--TTDEVTDeIISR 348
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 7-357 1.75e-80

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 249.25  E-value: 1.75e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITtshyDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEHLPP 86
Cdd:PRK08997   5 ITVIPGDGIGPSIIDATLKILDKLGCDFEYEFA----DAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPVGEGFTS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  87 DQqpergalLPLRKHFKLFSNLRPAKLYQGLEAfcplRADiaanGFDILCVRELTGGIYFGQpkGREGSGQYEKAFDTEV 166
Cdd:PRK08997  81 IN-------VTLRKKFDLYANVRPVLSFPGTKA----RYD----NIDIITVRENTEGMYSGE--GQTVSEDGETAEATSI 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 167 YHRFEIERIARIAFESARKR-RHKVTSIDKANVLQS-SILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244
Cdd:PRK08997 144 ITRKGAERIVRFAYELARKEgRKKVTAVHKANIMKStSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIV 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGfGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADDAACAIER 324
Cdd:PRK08997 224 TTNLFGDILSDLCAGLVGGLGMAPGANIGRDA-AIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEY-LGMPDKAERIRK 301

                        330       340       350
                 ....*....|....*....|....*....|....
gi 732685956 325 AINRALEEGIR-TGDLarGAAAVSTDEMGDIIAR 357
Cdd:PRK08997 302 AIVAVIEAGDRtTRDL--GGTHGTTDFTQAVIDR 333
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
1-357 1.05e-59

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 199.73  E-value: 1.05e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRfaMRITTSHYdvgGAAIDNHGQP--LPPATVEGCEQADAVLFGSV-- 76
Cdd:PRK09222   1 MAEKTPITVAYGDGIGPEIMEAVLKILEAAGAP--LEIETIEI---GEKVYKKGWTsgISPSAWESIRRTKVLLKAPItt 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  77 ---GGPKwehlppdqqperGALLPLRKHFKLFSNLRPAKLYqglEAFCPLRADiaanGFDILCVRE----LTGGIYFGQp 149
Cdd:PRK09222  76 pqgGGYK------------SLNVTLRKTLGLYANVRPCVSY---HPFVETKHP----NLDVVIIREneedLYAGIEHRQ- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 150 kgregsgqyekafDTEVYHRFEI------ERIARIAFESARKR-RHKVTSIDKANVL-QSSILWREIVNEIATEYPDVEL 221
Cdd:PRK09222 136 -------------TPDVYQCLKLisrpgsEKIIRYAFEYARANgRKKVTCLTKDNIMkLTDGLFHKVFDEIAKEYPDIEA 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 222 AHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGfGLYEPAGGSAPDIAGKNIANPIAQ 301
Cdd:PRK09222 203 EHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVGLAGSANIGEEY-AMFEAVHGSAPDIAGKNIANPSGL 281

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 302 ILSLALLLRYsLDADDAACAIERAINRALEEGIRTGDL---ARGAAAVSTDEMGD-IIAR 357
Cdd:PRK09222 282 LNAAVMMLVH-IGQFDIAELIENAWLKTLEDGIHTADIyneGVSKKKVGTKEFAEaVIEN 340
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 9-349 7.16e-49

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 168.52  E-value: 7.16e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   9 VLPGDGIGPEVMTQALKVLDAVRNRFAMRittSHYDvgGAAIDNHGQplppaTVEGCEQADAVLFGSVG--GPKwehLPP 86
Cdd:PLN00118  46 LFPGDGIGPEIAESVKQVFTAAGVPIEWE---EHYV--GTTVDPRTG-----SFLTWESLESVRRNKVGlkGPM---ATP 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  87 DQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAfcplRADiaanGFDILCVRELTGGIYFGQpKGREGSGQYEKafdTEV 166
Cdd:PLN00118 113 IGKGHRSLNLTLRKELGLYANVRPCYSLPGYKT----RYD----DVDLVTIRENTEGEYSGL-EHQVVRGVVES---LKI 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 167 YHRFEIERIARIAFESARKR-RHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244
Cdd:PLN00118 181 ITRQASLRVAEYAFHYAKTHgRKRVSAIHKANIMKKTDgLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLV 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADDAACAIER 324
Cdd:PLN00118 261 MPNLYGDIISDLCAGLIGGLGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRH-LKLNEQAEQIHN 339

                        330       340
                 ....*....|....*....|....*.
gi 732685956 325 AINRALEEG-IRTGDLarGAAAVSTD 349
Cdd:PLN00118 340 AILNTIAEGkYRTADL--GGSSTTTD 363
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 12-357 7.91e-44

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 156.04  E-value: 7.91e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  12 GDGIGPEVMTQALKVLD-AVRNRFAM--RITTSHYDVGGAAIDNHGQPLPPATVEGCEQadavlFG-SVGGPkwehL-PP 86
Cdd:COG0538   26 GDGIGPEITRAIWKVIDaAVEKAYGGkrDIEWKEVDAGEKARDETGDWLPDETAEAIKE-----YGvGIKGP----LtTP 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  87 DQQPER---GALlplRKHFKLFSNLRPAKLYQGLEAfcPLRAdiaANGFDILCVRELTGGIY------FGQPK------- 150
Cdd:COG0538   97 VGGGWRslnVTI---RQILDLYVCRRPVRYFKGVPS--PVKH---PEKVDIVIFRENTEDIYagiewkAGSPEalkliff 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 151 GREGSGQYEKAFDTEV------YHRFEIERIARIAFESA--RKRRHkVTSIDKANvlqssIL------WREIVNEIA-TE 215
Cdd:COG0538  169 LEDEMGVTVIRFPEDSgigikpVSDEGTERLVRAAIQYAldNKRKS-VTLVHKGN-----IMkftegaFKDWGYEVAeEE 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 216 YPDVELA-------------------HMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG 276
Cdd:COG0538  243 FGDKFITegpwekykgpkpagkivykDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDG 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 277 FGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGD 353
Cdd:COG0538  323 GAEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRH-RGWLEAADLIEKAVEKTIESGKVTYDLARlmeGATELSTSEFGD 401


                 ....*
gi 732685956 354 -IIAR 357
Cdd:COG0538  402 aIIEN 406
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
12-353 1.82e-40

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 147.29  E-value: 1.82e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  12 GDGIGPEVMTQALKVLD-AVRNRFAMRITTSHYDV--GGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGP---KWehlp 85
Cdd:PRK06451  31 GDGIGPEITHAAMKVINkAVEKAYGSDREIKWVEVlaGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPigkGW---- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  86 pdqqpeRGALLPLRKHFKLFSNLRPAKLYQGLEAfcPLRAdiaANGFDILCVRELTGGIYFGqpkgregsgqYEKAFDTE 165
Cdd:PRK06451 107 ------KSINVAIRLMLDLYANIRPVKYIPGIES--PLKN---PEKIDLIIFRENTDDLYRG----------IEYPYDSE 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 166 --------------------------VYHRFEIERIARIAFESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIAT-EY 216
Cdd:PRK06451 166 eakkirdflrkelgveveddtgigikLISKFKTQRIARMAIKYAiDHKRKKVTIMHKGNVMKyTEGAFREWAYEVALkEF 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 217 PDV-----ELAHMYI---------------DNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG 276
Cdd:PRK06451 246 RDYvvteeEVTKNYNgvppsgkviindriaDNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTG 325

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 732685956 277 fGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADDAACAIERAINRALEEGIRTGDLAR--GAAAVSTDEMGD 353
Cdd:PRK06451 326 -GMFEAIHGTAPKYAGKNVANPTGIIKGGELMLRF-MGWDKAADLIDKAIMESIKQKKVTQDLARfmGVRALSTTEYTD 402
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 7-339 5.80e-33

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 126.13  E-value: 5.80e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   7 IAVLPGDGIGPEVMTQALKVLDAVRnrfaMRITTSHYDVGGAAIDnhgqpLPPATVEGCEQADAVLFGSVggpkwehlpp 86
Cdd:PLN00123  33 VTLIPGDGIGPLVTGAVEQVMEAMH----APVYFERYEVHGDMKK-----VPEEVLESIRRNKVCLKGGL---------- 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  87 dQQPERGAL----LPLRKHFKLFSNLRPAKLYQGLeafcPLRADiaanGFDILCVRELTGGIYFG-QPKGREGSGQYEKa 161
Cdd:PLN00123  94 -ATPVGGGVsslnVQLRKELDLFASLVNCFNLPGL----PTRHE----NVDIVVIRENTEGEYSGlEHEVVPGVVESLK- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 162 fdteVYHRFEIERIARIAFESAR-KRRHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239
Cdd:PLN00123 164 ----VITKFCSERIAKYAFEYAYlNNRKKVTAVHKANIMkLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQ 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNeQGFGLYEpAGGSAPDIAGKNI-----ANPIAQILSLALLLRYsLD 314
Cdd:PLN00123 240 FDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVG-ADHAVFE-QGASAGNVGNEKLveqkkANPVALLLSSAMMLRH-LQ 316

                        330       340
                 ....*....|....*....|....*.
gi 732685956 315 ADDAACAIERAINRALEEG-IRTGDL 339
Cdd:PLN00123 317 FPSFADRLETAVKRVIAEGkYRTKDL 342
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 7-355 7.40e-20

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 90.12  E-value: 7.40e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956   7 IAVLPGDGIGPEVMTQALKVLDA-VRNRFAMRITTSHYDV--GGAAIDNHGQP--LPPATVEGCEQADAVLFGS----VG 77
Cdd:PRK07006  22 IPFIEGDGIGPDITPAMLKVVDAaVEKAYKGERKISWMEIyaGEKATKVYGEDvwLPEETLDLIREYRVAIKGPlttpVG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956  78 GPKwehlppdqqpeRGALLPLRKHFKLFSNLRPAKLYQGLEAfcPLRAdiaANGFDILCVRELTGGIYFGQpKGREGSGQ 157
Cdd:PRK07006 102 GGI-----------RSLNVALRQELDLYVCLRPVRYFKGVPS--PVKR---PEDTDMVIFRENSEDIYAGI-EWKAGSAE 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 158 YEKAFD--------TEVyhRFE--------------IERIARIAFESA-RKRRHKVTSIDKANVLQSS----------IL 204
Cdd:PRK07006 165 AKKVIKflqeemgvKKI--RFPetsgigikpvseegTERLVRAAIEYAiDNDRKSVTLVHKGNIMKFTegafkdwgyqLA 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 205 WREIVNEIATEYPdvelaHMYIDNATMQ---LIKD-------------PSQFDVLLCSNLFGDILSDECAMITGSMGMLP 268
Cdd:PRK07006 243 EEEFGDELIDGGP-----WDKIKNPETGkeiIVKDsiadaflqqillrPAEYDVIATMNLNGDYISDALAAQVGGIGIAP 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 269 SASLNEqGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADDAACAIERAINRALEEGIRTGDLAR---GAAA 345
Cdd:PRK07006 318 GANIND-GHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRH-MGWTEAADLIIKSMEKTIASKTVTYDFARlmeGATE 395

                        410
                 ....*....|
gi 732685956 346 VSTDEMGDII 355
Cdd:PRK07006 396 VKCSEFGDAL 405
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
227-341 2.64e-11

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 64.73  E-value: 2.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 227 DNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGfGLYEPAGGSAPDIAGKNIANPIAQILSLA 306
Cdd:PRK07362 340 DSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNA-AIFEATHGTAPKHAGLDRINPGSVILSGV 418

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 732685956 307 LLLRYsLDADDAACAIERAINRALEEGIRTGDLAR 341
Cdd:PRK07362 419 MMLEY-LGWQEAADLITKGLSAAIANKQVTYDLAR 452
PTZ00435 PTZ00435
isocitrate dehydrogenase; Provisional
 223-357 6.77e-06

isocitrate dehydrogenase; Provisional


Pssm-ID: 240417  Cd Length: 413  Bit Score: 47.68  E-value: 6.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 223 HMYIDNATMQLIKDPSQFdVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG-LYEPAGGS------APDIAGKNI 295
Cdd:PTZ00435 249 HRLIDDMVAQAIKSEGGF-VWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTvEAEAAHGTvtrhyrQHQKGKETS 327

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 732685956 296 ANPIAQIL--SLALLLRYSLDADDA----ACAIERAINRALEEGIRTGDLA---RGAAAVS------TDEMGDIIAR 357
Cdd:PTZ00435 328 TNSIASIFawTRGLAHRAKLDNNQElvkfCQALERSCIETIEAGFMTKDLAicvHGSSKVTrsdylnTEEFIDKVAE 404
PLN00096 PLN00096
isocitrate dehydrogenase (NADP+); Provisional
 217-356 1.37e-04

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 177715  Cd Length: 393  Bit Score: 43.48  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 217 PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPS--ASLNEQGFGL--YEPAGGSAPD--- 289
Cdd:PLN00096 235 SGDELVHLLSDAATMKLVVWTDGGFGMAAHNYDGDVLTDELAQVHKSPGFITSnlVGVDENGTLIkeFEASHGTVTDmde 314

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 732685956 290 --IAGKNIA-NPIAQILSLALLLRYSLDADDAACAIE------RA-INRALEEGIRTGDLArGAAAVSTDEMGDIIA 356
Cdd:PLN00096 315 arLRGEETSlNPLGMVEGLIGAMNHAADVHGGKERVHpftaklRAvIHKLFREGRGTRDLC-GAGGLTTEQFIDAVA 390
PRK08299 PRK08299
NADP-dependent isocitrate dehydrogenase;
206-340 2.30e-04

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236226  Cd Length: 402  Bit Score: 42.92  E-value: 2.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732685956 206 REIVNEI-ATEYPD------VELAHMYIDNATMQLIKDPSQFdVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG 278
Cdd:PRK08299 222 KDIFQEVyEAEFKEkfeaagITYEHRLIDDMVASALKWEGGY-VWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKT 300

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 732685956 279 L-YEPAGGSAPD-----IAGKNIA-NPIAQIL--SLALLLRYSLDADDA----ACAIERAINRALEEGIRTGDLA 340
Cdd:PRK08299 301 VeAEAAHGTVTRhyrqhQKGEETStNPIASIFawTRGLAHRGKLDGNPElvkfADTLEKVCIETVESGFMTKDLA 375
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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