|
Name |
Accession |
Description |
Interval |
E-value |
| DnaE |
COG0587 |
DNA polymerase III, alpha subunit [Replication, recombination and repair]; |
4-958 |
0e+00 |
|
DNA polymerase III, alpha subunit [Replication, recombination and repair];
Pssm-ID: 440352 [Multi-domain] Cd Length: 1050 Bit Score: 687.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 4 LMVRTDFSLGESALKAENAVKIARDAGYTAVISADSMNIASVIPLQRAA-GDDMAVICGVklnvvddptyehRARLAKES 82
Cdd:COG0587 8 LHVHSEYSLLDGASRPEELVARAAELGMPALAITDHGNLFGAVRFYKAAkKAGIKPIIGC------------ELYVAPGS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 83 ERcmeslvrDRSYCFTALIKNEQGYRDVCELMTLANKREQFYFVPRLALDQLAAaYAKGNIILLTSDIGSVFQR------ 156
Cdd:COG0587 76 RD-------DAGYHLVLLAKNREGYRNLCRLLSRAYLEGFYKGKPRIDLEDLAE-HSEGLIALSGCLAGEVGQAllagqy 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 157 RDFAKIIGTLVTAGGrDNFYSVVYPHPTPFYDQINVRAMKVASALKIEPVAFYPAYYEAVDDADIKDIAHMVTNNIKIDQ 236
Cdd:COG0587 148 DEAEAALARLKDIFG-DRFYLELQRHGLPEDRRVNAALLELARELGLPLVATNDVHYLNPEDAEAHDVLLCIRTGKTLDD 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 237 PHRLRIPhqrdnavNGRRHLL---EALKAFSvrmDVPvtAAMASTTQdtIIEACTWRWHELPPALPK------MADDEpa 307
Cdd:COG0587 227 PGRRRFA-------NAERYLKspeEMAELFA---DLP--EALANTLE--IAERCNFSLDLGKYQLPKfpvpegETEEE-- 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 308 TLMKLAVAGLRKRLttkefgytpPASEHRVYVDRLKYEMDTLTRLGFCGYFLMVRDLMNHSRETGIPVGPGRGSSAGSLV 387
Cdd:COG0587 291 YLRKLAEEGLERRY---------PEGIPEEYRERLEYELDVIEKMGFPGYFLIVWDFIRWARSNGIPVGPGRGSAAGSLV 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 388 AWCIGITNVDPIRHGLLFERFINPERLDLPDADLDFSQARRHEVIEYLNERYGEDYVAGIPNFTYLGAASALRDTARIYG 467
Cdd:COG0587 362 AYALGITDVDPIRYDLLFERFLNPERVSMPDIDIDFCHERREEVIQYVYEKYGRDRVAQIATFGTMRARAAIRDVGRVLG 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 468 VDAADM-AVSKEF-----KNLEDDSLSLEELREqLASLDKyatKYPEAFKAACKLQSLMRGFGRHAAGMIVAGVPLVERT 541
Cdd:COG0587 442 LPYGEVdRLAKLIpndpgITLEKALEEEPELRE-LYDSDP---EVRRLLDLARKLEGLPRHLSTHAGGVVISDDPLTDLV 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 542 PVEL--RGNARCIAFDKRYCEAMGLIKLDVLGLATLDLLDSAKRYIKESTGEDINLDAIPLDDRKVLDGFAAGYTQGVFQ 619
Cdd:COG0587 518 PLERaaMGGRPVTQFDKDDVEALGLLKFDFLGLRTLTVIRDALDLIKENRGIDIDLADIPLDDPKTYELLQRGDTIGVFQ 597
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 620 LESGPMRKLLKDLgggiEPMSFKTVVATTALFRPGPIQSGMLDDYVSVAKGFMAPQSLHPVLDELTAETNGVILYQEQTM 699
Cdd:COG0587 598 LESRGMRSLLKRL----KPDCFEDLVALVALYRPGPMQGGMVPPYIRRKHGREPVEYPHPELEPILKETYGVIVYQEQVM 673
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 700 NATRLLAGFTMAEADGVRKAIGKKDMEKMKSMGEKFVvqaqagwidvemedgttqrihraehfkceDGALRTveealeag 779
Cdd:COG0587 674 QIAQVLAGFSLGEADLLRRAMGKKKKEEMAKQREKFV-----------------------------EGAVAN-------- 716
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 780 vklpmaavrvtgsqpGLSETKAKEIWDAFEKNGAYQFNKSHPVAYSLISYQSMWLKTHYPAEFFAAALT--ILGEDKHQG 857
Cdd:COG0587 717 ---------------GYDEEFAEEIFDQIEKFAGYGFNKSHAAAYALLAYQTAYLKAHYPAEFMAALLNsqPMGFYKPAQ 781
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 858 LVKDALTYGIHVLPPDVNVSSNRIeirTLEDGSQVLYApFSAVKGCSENGCQAIMRAREKvGGKFESLEQFEEAVEKRac 937
Cdd:COG0587 782 YVQEARRHGIEVLPPDVNESDWDF---TVEPGGAIRLG-LGAIKGVGEAAAEAIVAAREE-NGPFTSLFDFCRRVDLR-- 854
|
970 980
....*....|....*....|.
gi 755429649 938 ACNSRVRESLQKVGAFASIEP 958
Cdd:COG0587 855 KLNKRVLEALIKAGAFDSLGP 875
|
|
| dnaE |
PRK05673 |
DNA polymerase III subunit alpha; Validated |
4-986 |
0e+00 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 235554 [Multi-domain] Cd Length: 1135 Bit Score: 605.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 4 LMVRTDFSLGESALKAENAVKIARDAGYTAVISADSMNIASVIPLQRAA-GDDMAVICGVKLNVvddptyeHRARLAKES 82
Cdd:PRK05673 5 LHVHSEYSLLDGAAKIKPLVKKAAELGMPAVALTDHGNLFGAVEFYKAAkGAGIKPIIGCEAYV-------APEKKDDVS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 83 ERcmeslvrdRSYC-FTALIKNEQGYRDVCELMTLANKREQFYFVPRLALDQLAAaYAKGnIILLTSDIGSvfqrrdfak 161
Cdd:PRK05673 78 GG--------GAYThLTLLAKNETGYRNLFKLSSRAYLEGQYGYKPRIDREWLAE-HSEG-LIALSGCPSG--------- 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 162 IIGTLVTAGGR---------------DNFYSVVYPHPTPFYDQINVRAMKVASALKIEPVAFYPAYYEAVDDADIKDIAH 226
Cdd:PRK05673 139 EVGTALLAGQYdeaeeaaaeyqeifgDRFYLELMRHGLPIERRVEHALLELAKELGLPLVATNDVHYLTPEDAEAHEALL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 227 MVTNNIKIDQPHRLRiphqRDnavnGRRHLL----EALKAFSvrmDVPvtAAMASTTQdtIIEACTWRWHELPPALPKMA 302
Cdd:PRK05673 219 CIAEGKTLDDPDRFR----FY----SPEQYLksaeEMRELFA---DLP--EALDNTVE--IAERCNVEVRLGKPFLPRFP 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 303 DDEPAT----LMKLAVAGLRKRLttkEFGytPPASEHRVYVDRLKYEMDTLTRLGFCGYFLMVRDLMNHSRETGIPVGPG 378
Cdd:PRK05673 284 TPDGETeedyLRKEAKEGLEERL---AFL--FPDEERPEYVERLEYELDVIIQMGFPGYFLIVADFIQWAKDNGIPVGPG 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 379 RGSSAGSLVAWCIGITNVDPIRHGLLFERFINPERLDLPDADLDFSQARRHEVIEYLNERYGEDYVAGIPNFTYLGAASA 458
Cdd:PRK05673 359 RGSGAGSLVAYALGITDLDPLRFGLLFERFLNPERVSMPDFDIDFCQDRRDEVIRYVAEKYGRDAVAQIITFGTMKAKAV 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 459 LRDTARI----YG-VDA------ADMAVSKEfKNLEDDslslEELREQLASLDKYAtkypEAFKAACKLQSLMRGFGRHA 527
Cdd:PRK05673 439 IRDVGRVlgmpYGfVDRitklipPDPGITLA-KAYEEE----PELRELYESDPEVK----RLIDMARKLEGLTRNAGVHA 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 528 AGMIVAGVPLVERTPVELRGNARCIA--FDKRYCEAMGLIKLDVLGLATLDLLDSAKRYIKESTGEDINLDAIPLDDRKV 605
Cdd:PRK05673 510 AGVVISPTPLTDFVPLYRDPDSGMPVtqFDMKDVEAAGLVKFDFLGLRTLTIIDDALKLIKKRRGIDVDLEAIPLDDPKT 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 606 LDGFAAGYTQGVFQLESGPMRKLLKDLgggiEPMSFKTVVATTALFRPGPIQSGMLDDYVSVAKGFMAPQSLHPVLDELT 685
Cdd:PRK05673 590 YELLQRGETLGVFQLESRGMRDLLKRL----KPDCFEDIIALVALYRPGPMESGMIPNFIDRKHGREEIEYPHPELEPIL 665
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 686 AETNGVILYQEQTMNATRLLAGFTMAEADGVRKAIGKKDMEKMKSMGEKFVvqaqagwidvemedgttqrihraehfkce 765
Cdd:PRK05673 666 KETYGIIVYQEQVMQIAQVLAGYSLGGADLLRRAMGKKKPEEMAKQREIFV----------------------------- 716
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 766 DGALRTveealeagvklpmaavrvtgsqpGLSETKAKEIWDAFEKNGAYQFNKSHPVAYSLISYQSMWLKTHYPAEFFAA 845
Cdd:PRK05673 717 EGAKKN-----------------------GIDEEAADAIFDLLEKFAGYGFNKSHAAAYALVSYQTAYLKAHYPAEFMAA 773
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 846 ALTILGE--DKHQGLVKDALTYGIHVLPPDVNVSSNRIEIrtleDGSQVLYApFSAVKGCSENGCQAIMRAREKvGGKFE 923
Cdd:PRK05673 774 LLTSDMDntDKVAVYLDECRRMGIKVLPPDVNESLYDFTV----VDGDIRYG-LGAIKGVGEGAVEAIVEAREE-GGPFK 847
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755429649 924 SLEQFEEAVEKRacACNSRVRESLQKVGAFASIEPgslpatdperlrDQAELMGNL--VIDAVKA 986
Cdd:PRK05673 848 DLFDFCARVDLK--KVNKRVLESLIKAGAFDSLGP------------NRAALLASLedAVDAADQ 898
|
|
| polc |
TIGR00594 |
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are ... |
4-958 |
0e+00 |
|
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273161 [Multi-domain] Cd Length: 1022 Bit Score: 596.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 4 LMVRTDFSLGESALKAENAVKIARDAGYTAVISADSMNIASVIPLQRAA-GDDMAVICGVKLNVVDDptyehrARLAKES 82
Cdd:TIGR00594 4 LHVHSDYSLLDGAAKIKPLVKKAKELGMPALALTDHGNMFGAVEFYKACkKAGIKPIIGCEAYVAPG------SRFDKKR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 83 ERcmeslVRDRSYCFTALIKNEQGYRDVCELMTLANKrEQFYFVPRLALDQLAAaYAKGnIILLTSDIGSVFQRR----- 157
Cdd:TIGR00594 78 IS-----KGKEAYHLILLAKNNTGYRNLMKLSSLAYL-EGFYYKPRIDKELLEE-HSEG-LIALSACLSGEVPYLlllge 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 158 ---------DFAKIIGtlvtaggrDNFYSVVYPHPTPFYDQINVRAMKVASALKIEPVAFYPAYYEAVDDADIKDIAHMV 228
Cdd:TIGR00594 150 erlaeeaalKYQEIFG--------DDYYLELQDHGIPEQRVVNEALLEISEELGIPLVATNDVHYINPEDAHAHEILLCI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 229 TNNIKIDQPHRLR-IPHQRDNAVNGRRHLLEAlkafsvrmDVPvtAAMASTTQdtIIEACTWRWHELPPALPKMADDEP- 306
Cdd:TIGR00594 222 QTGKTLSDPKRLKfYSDEFYLKSPEEMAELFA--------DIP--EALANTVE--IAERCNLVDVKLGPPRLPSYQIPPd 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 307 -----ATLMKLAVAGLRKRLTTKEFGYTPpaseHRVYVDRLKYEMDTLTRLGFCGYFLMVRDLMNHSRETGIPVGPGRGS 381
Cdd:TIGR00594 290 ftsqeDYLRHLADEGLRERLAAGPPGYKR----RAQYKERLEYELDVINSMGFPGYFLIVWDFIKWAKDHGIPVGPGRGS 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 382 SAGSLVAWCIGITNVDPIRHGLLFERFINPERLDLPDADLDFSQARRHEVIEYLNERYGEDYVAGIPNFTYLGAASALRD 461
Cdd:TIGR00594 366 AAGSLVAYALKITDIDPIKHGLLFERFLNPERISMPDIDIDFCDERRDEVIEYVADKYGHDNVAQIITFGTMKAKAALRD 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 462 TARIYGVDAADmaVSKEFKNLEDD-SLSLEELREQLASLDKYATKYPEA---FKAACKLQSLMRGFGRHAAGMIVAGVPL 537
Cdd:TIGR00594 446 VARVLDIPYAE--ADRIAKLIPPRpGKTLKEALEASPQLRQLYEEDPEVkqlIDMARKLEGLNRNAGVHAAGVVISSEPL 523
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 538 VERTPVELRGNARCIA--FDKRYCEAMGLIKLDVLGLATLDLLDSAKRYIKESTGEDINLDAIPLDDRKVLDGFAAGYTQ 615
Cdd:TIGR00594 524 TDYVPLYKDKEGGAIStqYDMDDLEAVGLLKMDFLGLKTLTLIQDATELIRKRRGIDLDIASIPLDDKKTFSLLQEGDTT 603
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 616 GVFQLESGPMRKLLKDLgggiEPMSFKTVVATTALFRPGPIQSGMLDDYVSVAKGFMAPQSLHPVLDELTAETNGVILYQ 695
Cdd:TIGR00594 604 GVFQLESRGMQDLLKRL----KPDGFEDIIAVNALYRPGPMESGMIPDFIDRKHGREPIEYPHPLLEPILKETYGVIVYQ 679
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 696 EQTMNATRLLAGFTMAEADGVRKAIGKKDMEKMKSMGEKFVvqaqagwidvemedgttqrihraehfkceDGALRTveea 775
Cdd:TIGR00594 680 EQVMQIAQRLAGFSLGEADLLRRAMGKKKAEEMAKEREKFV-----------------------------EGAEKN---- 726
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 776 leagvklpmaavrvtgsqpGLSETKAKEIWDAFEKNGAYQFNKSHPVAYSLISYQSMWLKTHYPAEFFAAALT--ILGED 853
Cdd:TIGR00594 727 -------------------GYDPEIAENLFDLIEKFAGYGFNKSHAAAYGMISYQTAYLKANYPAEFMAALLTseINDIE 787
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 854 KHQGLVKDALTYGIHVLPPDVNVSSNRIEirtlEDGSQVLYApFSAVKGCSENGCQAIMRAREKvGGKFESLEQFEEAVE 933
Cdd:TIGR00594 788 KVAVYIAEAKKMGIEVLPPDINESGQDFA----VEDKGIRYG-LGAIKGVGESVVKSIIEERNK-NGPFKSLFDFINRVD 861
|
970 980
....*....|....*....|....*
gi 755429649 934 KRacACNSRVRESLQKVGAFASIEP 958
Cdd:TIGR00594 862 FK--KLNKKVLEALIKAGAFDSLGP 884
|
|
| DNA_pol3_alpha |
pfam07733 |
Bacterial DNA polymerase III alpha NTPase domain; |
309-571 |
5.20e-85 |
|
Bacterial DNA polymerase III alpha NTPase domain;
Pssm-ID: 400196 [Multi-domain] Cd Length: 259 Bit Score: 275.15 E-value: 5.20e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 309 LMKLAVAGLRKRLttkefgytpPASEHRVYVDRLKYEMDTLTRLGFCGYFLMVRDLMNHSRETGIPVGPGRGSSAGSLVA 388
Cdd:pfam07733 3 LRKLVEEGLKERY---------GEGLPEEYQERLEYELNVIIKMGFAGYFLIVWDLVKWAKDNGILVGPGRGSAAGSLVA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 389 WCIGITNVDPIRHGLLFERFINPERLDLPDADLDFSQARRHEVIEYLNERYGEDYVAGIPNFTYLGAASALRDTARIYGV 468
Cdd:pfam07733 74 YLLGITEVDPLKHDLLFERFLNPERVSMPDIDIDFEDERREEVIDYVKEKYGRDRVAQIATFGTYAAKSAIRDVGRALGL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 469 DAADM-AVSKEFKNLEDDSLSLEELREQLASLDKYATKYPEAFKAACKLQSLMRGFGRHAAGMIVAGVPLVERTPVELRG 547
Cdd:pfam07733 154 PYDEIdRLAKLIPFELGILEKALEEEPELKELIESDPEVKRLIELAKKLEGLPRHTGQHAGGVVISPDPLTDFVPLYKAD 233
|
250 260
....*....|....*....|....*.
gi 755429649 548 --NARCIAFDKRYCEAMGLIKLDVLG 571
Cdd:pfam07733 234 ddDRPVTQFDKDDLEDLGLLKMDFLG 259
|
|
| PHP_PolIIIA |
cd07431 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; ... |
4-150 |
2.43e-19 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such activity has not been found. It has been shown that the PHP domain of PolIIIA has a trinuclear metal complex and is capable of proofreading activity.
Pssm-ID: 213986 [Multi-domain] Cd Length: 179 Bit Score: 86.49 E-value: 2.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 4 LMVRTDFSLGESALKAENAVKIARDAGYTAVISADSMNIASVIPLQRAAGD-DMAVICGVKLNVVDDptyehrarlakes 82
Cdd:cd07431 3 LHVHSSYSLLDSAIRPEDLVARAKELGYSALALTDRNVLYGAVRFYKACKKaGIKPIIGLELTVEGD------------- 69
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755429649 83 ercmeslvrDRSYCFTALIKNEQGYRDVCELMTLANKREQFYFVPRLALDQLaAAYAKGNIILLTSDI 150
Cdd:cd07431 70 ---------GEPYPLLLLAKNNEGYQNLLRLSTAAMLGEEKDGVPYLDLEEL-AEAASGLLVVLLGPL 127
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DnaE |
COG0587 |
DNA polymerase III, alpha subunit [Replication, recombination and repair]; |
4-958 |
0e+00 |
|
DNA polymerase III, alpha subunit [Replication, recombination and repair];
Pssm-ID: 440352 [Multi-domain] Cd Length: 1050 Bit Score: 687.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 4 LMVRTDFSLGESALKAENAVKIARDAGYTAVISADSMNIASVIPLQRAA-GDDMAVICGVklnvvddptyehRARLAKES 82
Cdd:COG0587 8 LHVHSEYSLLDGASRPEELVARAAELGMPALAITDHGNLFGAVRFYKAAkKAGIKPIIGC------------ELYVAPGS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 83 ERcmeslvrDRSYCFTALIKNEQGYRDVCELMTLANKREQFYFVPRLALDQLAAaYAKGNIILLTSDIGSVFQR------ 156
Cdd:COG0587 76 RD-------DAGYHLVLLAKNREGYRNLCRLLSRAYLEGFYKGKPRIDLEDLAE-HSEGLIALSGCLAGEVGQAllagqy 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 157 RDFAKIIGTLVTAGGrDNFYSVVYPHPTPFYDQINVRAMKVASALKIEPVAFYPAYYEAVDDADIKDIAHMVTNNIKIDQ 236
Cdd:COG0587 148 DEAEAALARLKDIFG-DRFYLELQRHGLPEDRRVNAALLELARELGLPLVATNDVHYLNPEDAEAHDVLLCIRTGKTLDD 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 237 PHRLRIPhqrdnavNGRRHLL---EALKAFSvrmDVPvtAAMASTTQdtIIEACTWRWHELPPALPK------MADDEpa 307
Cdd:COG0587 227 PGRRRFA-------NAERYLKspeEMAELFA---DLP--EALANTLE--IAERCNFSLDLGKYQLPKfpvpegETEEE-- 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 308 TLMKLAVAGLRKRLttkefgytpPASEHRVYVDRLKYEMDTLTRLGFCGYFLMVRDLMNHSRETGIPVGPGRGSSAGSLV 387
Cdd:COG0587 291 YLRKLAEEGLERRY---------PEGIPEEYRERLEYELDVIEKMGFPGYFLIVWDFIRWARSNGIPVGPGRGSAAGSLV 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 388 AWCIGITNVDPIRHGLLFERFINPERLDLPDADLDFSQARRHEVIEYLNERYGEDYVAGIPNFTYLGAASALRDTARIYG 467
Cdd:COG0587 362 AYALGITDVDPIRYDLLFERFLNPERVSMPDIDIDFCHERREEVIQYVYEKYGRDRVAQIATFGTMRARAAIRDVGRVLG 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 468 VDAADM-AVSKEF-----KNLEDDSLSLEELREqLASLDKyatKYPEAFKAACKLQSLMRGFGRHAAGMIVAGVPLVERT 541
Cdd:COG0587 442 LPYGEVdRLAKLIpndpgITLEKALEEEPELRE-LYDSDP---EVRRLLDLARKLEGLPRHLSTHAGGVVISDDPLTDLV 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 542 PVEL--RGNARCIAFDKRYCEAMGLIKLDVLGLATLDLLDSAKRYIKESTGEDINLDAIPLDDRKVLDGFAAGYTQGVFQ 619
Cdd:COG0587 518 PLERaaMGGRPVTQFDKDDVEALGLLKFDFLGLRTLTVIRDALDLIKENRGIDIDLADIPLDDPKTYELLQRGDTIGVFQ 597
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 620 LESGPMRKLLKDLgggiEPMSFKTVVATTALFRPGPIQSGMLDDYVSVAKGFMAPQSLHPVLDELTAETNGVILYQEQTM 699
Cdd:COG0587 598 LESRGMRSLLKRL----KPDCFEDLVALVALYRPGPMQGGMVPPYIRRKHGREPVEYPHPELEPILKETYGVIVYQEQVM 673
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 700 NATRLLAGFTMAEADGVRKAIGKKDMEKMKSMGEKFVvqaqagwidvemedgttqrihraehfkceDGALRTveealeag 779
Cdd:COG0587 674 QIAQVLAGFSLGEADLLRRAMGKKKKEEMAKQREKFV-----------------------------EGAVAN-------- 716
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 780 vklpmaavrvtgsqpGLSETKAKEIWDAFEKNGAYQFNKSHPVAYSLISYQSMWLKTHYPAEFFAAALT--ILGEDKHQG 857
Cdd:COG0587 717 ---------------GYDEEFAEEIFDQIEKFAGYGFNKSHAAAYALLAYQTAYLKAHYPAEFMAALLNsqPMGFYKPAQ 781
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 858 LVKDALTYGIHVLPPDVNVSSNRIeirTLEDGSQVLYApFSAVKGCSENGCQAIMRAREKvGGKFESLEQFEEAVEKRac 937
Cdd:COG0587 782 YVQEARRHGIEVLPPDVNESDWDF---TVEPGGAIRLG-LGAIKGVGEAAAEAIVAAREE-NGPFTSLFDFCRRVDLR-- 854
|
970 980
....*....|....*....|.
gi 755429649 938 ACNSRVRESLQKVGAFASIEP 958
Cdd:COG0587 855 KLNKRVLEALIKAGAFDSLGP 875
|
|
| dnaE |
PRK05673 |
DNA polymerase III subunit alpha; Validated |
4-986 |
0e+00 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 235554 [Multi-domain] Cd Length: 1135 Bit Score: 605.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 4 LMVRTDFSLGESALKAENAVKIARDAGYTAVISADSMNIASVIPLQRAA-GDDMAVICGVKLNVvddptyeHRARLAKES 82
Cdd:PRK05673 5 LHVHSEYSLLDGAAKIKPLVKKAAELGMPAVALTDHGNLFGAVEFYKAAkGAGIKPIIGCEAYV-------APEKKDDVS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 83 ERcmeslvrdRSYC-FTALIKNEQGYRDVCELMTLANKREQFYFVPRLALDQLAAaYAKGnIILLTSDIGSvfqrrdfak 161
Cdd:PRK05673 78 GG--------GAYThLTLLAKNETGYRNLFKLSSRAYLEGQYGYKPRIDREWLAE-HSEG-LIALSGCPSG--------- 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 162 IIGTLVTAGGR---------------DNFYSVVYPHPTPFYDQINVRAMKVASALKIEPVAFYPAYYEAVDDADIKDIAH 226
Cdd:PRK05673 139 EVGTALLAGQYdeaeeaaaeyqeifgDRFYLELMRHGLPIERRVEHALLELAKELGLPLVATNDVHYLTPEDAEAHEALL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 227 MVTNNIKIDQPHRLRiphqRDnavnGRRHLL----EALKAFSvrmDVPvtAAMASTTQdtIIEACTWRWHELPPALPKMA 302
Cdd:PRK05673 219 CIAEGKTLDDPDRFR----FY----SPEQYLksaeEMRELFA---DLP--EALDNTVE--IAERCNVEVRLGKPFLPRFP 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 303 DDEPAT----LMKLAVAGLRKRLttkEFGytPPASEHRVYVDRLKYEMDTLTRLGFCGYFLMVRDLMNHSRETGIPVGPG 378
Cdd:PRK05673 284 TPDGETeedyLRKEAKEGLEERL---AFL--FPDEERPEYVERLEYELDVIIQMGFPGYFLIVADFIQWAKDNGIPVGPG 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 379 RGSSAGSLVAWCIGITNVDPIRHGLLFERFINPERLDLPDADLDFSQARRHEVIEYLNERYGEDYVAGIPNFTYLGAASA 458
Cdd:PRK05673 359 RGSGAGSLVAYALGITDLDPLRFGLLFERFLNPERVSMPDFDIDFCQDRRDEVIRYVAEKYGRDAVAQIITFGTMKAKAV 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 459 LRDTARI----YG-VDA------ADMAVSKEfKNLEDDslslEELREQLASLDKYAtkypEAFKAACKLQSLMRGFGRHA 527
Cdd:PRK05673 439 IRDVGRVlgmpYGfVDRitklipPDPGITLA-KAYEEE----PELRELYESDPEVK----RLIDMARKLEGLTRNAGVHA 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 528 AGMIVAGVPLVERTPVELRGNARCIA--FDKRYCEAMGLIKLDVLGLATLDLLDSAKRYIKESTGEDINLDAIPLDDRKV 605
Cdd:PRK05673 510 AGVVISPTPLTDFVPLYRDPDSGMPVtqFDMKDVEAAGLVKFDFLGLRTLTIIDDALKLIKKRRGIDVDLEAIPLDDPKT 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 606 LDGFAAGYTQGVFQLESGPMRKLLKDLgggiEPMSFKTVVATTALFRPGPIQSGMLDDYVSVAKGFMAPQSLHPVLDELT 685
Cdd:PRK05673 590 YELLQRGETLGVFQLESRGMRDLLKRL----KPDCFEDIIALVALYRPGPMESGMIPNFIDRKHGREEIEYPHPELEPIL 665
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 686 AETNGVILYQEQTMNATRLLAGFTMAEADGVRKAIGKKDMEKMKSMGEKFVvqaqagwidvemedgttqrihraehfkce 765
Cdd:PRK05673 666 KETYGIIVYQEQVMQIAQVLAGYSLGGADLLRRAMGKKKPEEMAKQREIFV----------------------------- 716
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 766 DGALRTveealeagvklpmaavrvtgsqpGLSETKAKEIWDAFEKNGAYQFNKSHPVAYSLISYQSMWLKTHYPAEFFAA 845
Cdd:PRK05673 717 EGAKKN-----------------------GIDEEAADAIFDLLEKFAGYGFNKSHAAAYALVSYQTAYLKAHYPAEFMAA 773
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 846 ALTILGE--DKHQGLVKDALTYGIHVLPPDVNVSSNRIEIrtleDGSQVLYApFSAVKGCSENGCQAIMRAREKvGGKFE 923
Cdd:PRK05673 774 LLTSDMDntDKVAVYLDECRRMGIKVLPPDVNESLYDFTV----VDGDIRYG-LGAIKGVGEGAVEAIVEAREE-GGPFK 847
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755429649 924 SLEQFEEAVEKRacACNSRVRESLQKVGAFASIEPgslpatdperlrDQAELMGNL--VIDAVKA 986
Cdd:PRK05673 848 DLFDFCARVDLK--KVNKRVLESLIKAGAFDSLGP------------NRAALLASLedAVDAADQ 898
|
|
| polc |
TIGR00594 |
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are ... |
4-958 |
0e+00 |
|
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273161 [Multi-domain] Cd Length: 1022 Bit Score: 596.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 4 LMVRTDFSLGESALKAENAVKIARDAGYTAVISADSMNIASVIPLQRAA-GDDMAVICGVKLNVVDDptyehrARLAKES 82
Cdd:TIGR00594 4 LHVHSDYSLLDGAAKIKPLVKKAKELGMPALALTDHGNMFGAVEFYKACkKAGIKPIIGCEAYVAPG------SRFDKKR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 83 ERcmeslVRDRSYCFTALIKNEQGYRDVCELMTLANKrEQFYFVPRLALDQLAAaYAKGnIILLTSDIGSVFQRR----- 157
Cdd:TIGR00594 78 IS-----KGKEAYHLILLAKNNTGYRNLMKLSSLAYL-EGFYYKPRIDKELLEE-HSEG-LIALSACLSGEVPYLlllge 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 158 ---------DFAKIIGtlvtaggrDNFYSVVYPHPTPFYDQINVRAMKVASALKIEPVAFYPAYYEAVDDADIKDIAHMV 228
Cdd:TIGR00594 150 erlaeeaalKYQEIFG--------DDYYLELQDHGIPEQRVVNEALLEISEELGIPLVATNDVHYINPEDAHAHEILLCI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 229 TNNIKIDQPHRLR-IPHQRDNAVNGRRHLLEAlkafsvrmDVPvtAAMASTTQdtIIEACTWRWHELPPALPKMADDEP- 306
Cdd:TIGR00594 222 QTGKTLSDPKRLKfYSDEFYLKSPEEMAELFA--------DIP--EALANTVE--IAERCNLVDVKLGPPRLPSYQIPPd 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 307 -----ATLMKLAVAGLRKRLTTKEFGYTPpaseHRVYVDRLKYEMDTLTRLGFCGYFLMVRDLMNHSRETGIPVGPGRGS 381
Cdd:TIGR00594 290 ftsqeDYLRHLADEGLRERLAAGPPGYKR----RAQYKERLEYELDVINSMGFPGYFLIVWDFIKWAKDHGIPVGPGRGS 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 382 SAGSLVAWCIGITNVDPIRHGLLFERFINPERLDLPDADLDFSQARRHEVIEYLNERYGEDYVAGIPNFTYLGAASALRD 461
Cdd:TIGR00594 366 AAGSLVAYALKITDIDPIKHGLLFERFLNPERISMPDIDIDFCDERRDEVIEYVADKYGHDNVAQIITFGTMKAKAALRD 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 462 TARIYGVDAADmaVSKEFKNLEDD-SLSLEELREQLASLDKYATKYPEA---FKAACKLQSLMRGFGRHAAGMIVAGVPL 537
Cdd:TIGR00594 446 VARVLDIPYAE--ADRIAKLIPPRpGKTLKEALEASPQLRQLYEEDPEVkqlIDMARKLEGLNRNAGVHAAGVVISSEPL 523
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 538 VERTPVELRGNARCIA--FDKRYCEAMGLIKLDVLGLATLDLLDSAKRYIKESTGEDINLDAIPLDDRKVLDGFAAGYTQ 615
Cdd:TIGR00594 524 TDYVPLYKDKEGGAIStqYDMDDLEAVGLLKMDFLGLKTLTLIQDATELIRKRRGIDLDIASIPLDDKKTFSLLQEGDTT 603
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 616 GVFQLESGPMRKLLKDLgggiEPMSFKTVVATTALFRPGPIQSGMLDDYVSVAKGFMAPQSLHPVLDELTAETNGVILYQ 695
Cdd:TIGR00594 604 GVFQLESRGMQDLLKRL----KPDGFEDIIAVNALYRPGPMESGMIPDFIDRKHGREPIEYPHPLLEPILKETYGVIVYQ 679
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 696 EQTMNATRLLAGFTMAEADGVRKAIGKKDMEKMKSMGEKFVvqaqagwidvemedgttqrihraehfkceDGALRTveea 775
Cdd:TIGR00594 680 EQVMQIAQRLAGFSLGEADLLRRAMGKKKAEEMAKEREKFV-----------------------------EGAEKN---- 726
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 776 leagvklpmaavrvtgsqpGLSETKAKEIWDAFEKNGAYQFNKSHPVAYSLISYQSMWLKTHYPAEFFAAALT--ILGED 853
Cdd:TIGR00594 727 -------------------GYDPEIAENLFDLIEKFAGYGFNKSHAAAYGMISYQTAYLKANYPAEFMAALLTseINDIE 787
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 854 KHQGLVKDALTYGIHVLPPDVNVSSNRIEirtlEDGSQVLYApFSAVKGCSENGCQAIMRAREKvGGKFESLEQFEEAVE 933
Cdd:TIGR00594 788 KVAVYIAEAKKMGIEVLPPDINESGQDFA----VEDKGIRYG-LGAIKGVGESVVKSIIEERNK-NGPFKSLFDFINRVD 861
|
970 980
....*....|....*....|....*
gi 755429649 934 KRacACNSRVRESLQKVGAFASIEP 958
Cdd:TIGR00594 862 FK--KLNKKVLEALIKAGAFDSLGP 884
|
|
| dnaE |
PRK06826 |
DNA polymerase III DnaE; Reviewed |
4-957 |
4.54e-153 |
|
DNA polymerase III DnaE; Reviewed
Pssm-ID: 235868 [Multi-domain] Cd Length: 1151 Bit Score: 484.39 E-value: 4.54e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 4 LMVRTDFSLGESALKAENAVKIARDAGYTAVISADSMNIASVIPLQRAAGD-DMAVICGVKLNVVDdptyehRARLAKES 82
Cdd:PRK06826 8 LHVHTEYSLLDGSARIKDLIKRAKELGMDSIAITDHGVMYGVVDFYKAAKKqGIKPIIGCEVYVAP------RSRFDKEP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 83 ERcmeslvRDRSYCFTALIKNEQGYRDVCELMTLANKrEQFYFVPRLALDQLAAaYAKGNIIL---LTSDIGSVFQRRDF 159
Cdd:PRK06826 82 DI------DNETYHLVLLAKNETGYKNLMKIVSKAFT-EGFYYKPRVDHELLKE-HSEGLIALsacLAGEVPRYILKGNY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 160 AK---IIGTLVTAGGRDNFYSVVYPHPTPFYDQINVRAMKVASALKIEPVAFYPAYYEAVDDADIKDIAHMVTNNIKIDQ 236
Cdd:PRK06826 154 EKakeAALFYKDIFGKENFYLELQDHGIPEQRKVNEELIKLSKELGIPLVATNDVHYIRKEDAKAHDVLLCIQTGKTVDD 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 237 PHRLRIPHQ------RDNAVNGRRHLLEALKafsvrmdvpvtaamasTTQdTIIEAC--TWRWHELppALPKMADDEPAT 308
Cdd:PRK06826 234 ENRMRFPSDefylksPEEMYELFSYVPEALE----------------NTV-KIAERCnvEFEFGKS--KLPKFPLPEGYD 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 309 ----LMKLAVAGLRKRlttkefgYTPPASEhrvYVDRLKYEMDTLTRLGFCGYFLMVRDLMNHSRETGIPVGPGRGSSAG 384
Cdd:PRK06826 295 pyeyLRELCYEGLKKR-------YPNPSEE---LIERLEYELSVIKQMGYVDYFLIVWDFIRFARENGIMVGPGRGSAAG 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 385 SLVAWCIGITNVDPIRHGLLFERFINPERLDLPDADLDFSQARRHEVIEYLNERYGEDYVAGIPNFTYLGAASALRDTAR 464
Cdd:PRK06826 365 SLVAYTLGITKIDPIKYNLLFERFLNPERVSMPDIDIDFCYERRQEVIDYVVEKYGKDRVAQIITFGTMAARAAIRDVGR 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 465 I----YG-VDA-ADM-------------AVSKEFKNLEDDSLSLEELreqlasLDKyatkypeafkaACKLQSLMRGFGR 525
Cdd:PRK06826 445 AlnypYAeVDRiAKMiptelgitidkalELNPELKEAYENDERVREL------IDT-----------ARALEGLPRHAST 507
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 526 HAAGMIVAGVPLVERTPVELRGNARCIAFDKRYCEAMGLIKLDVLGLATLDLLDSAKRYIKESTGEDINLDAIPLDDRKV 605
Cdd:PRK06826 508 HAAGVVISSEPLVEYVPLQKNDGSIVTQFTMTTLEELGLLKMDFLGLRTLTVIRDAVDLIKKNRGIEIDLDKIDYDDKKV 587
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 606 LDGFAAGYTQGVFQLESGPMRKLLKDLgggiEPMSFKTVVATTALFRPGPIQSgmLDDYVSVAKGFMAPQSLHPVLDELT 685
Cdd:PRK06826 588 YKMIGEGKTVGVFQLESAGMRSFMKEL----KPDSLEDIIAGISLYRPGPMDS--IPRYIKNKNNPEKIEYLHPKLEPIL 661
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 686 AETNGVILYQEQTMNATRLLAGFTMAEADGVRKAIGKKDMEKMKSMGEKFVvqaqAGWIDvemEDGTtqrihraehfkce 765
Cdd:PRK06826 662 KVTYGCIVYQEQVMQIVRDLAGYSMGRSDLVRRAMSKKKHDVMEEERKNFI----YGIVD---EGGP------------- 721
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 766 dGALRTveealeagvklpmaavrvtgsqpGLSETKAKEIWDAFEKNGAYQFNKSHPVAYSLISYQSMWLKTHYPAEFFAA 845
Cdd:PRK06826 722 -GCIRN-----------------------GIDEETANKIFDSMMDFASYAFNKSHAAAYAVVAYQTAYLKRYYPVEFMAA 777
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 846 ALT-ILG-EDKHQGLVKDALTYGIHVLPPDVNVSSNRIEIrtleDGSQVLYApFSAVKGCSENGCQAIMRAREKvGGKFE 923
Cdd:PRK06826 778 LLNsVMGnSDKVAFYIEECRRLGIEVLPPDINESYSKFTV----EGDKIRFG-LAAVKNVGENAIDSIVEEREK-KGKFK 851
|
970 980 990
....*....|....*....|....*....|....
gi 755429649 924 SLEQFEEAVEKRacACNSRVRESLQKVGAFASIE 957
Cdd:PRK06826 852 SLVDFCERVDTS--QINKRAVESLIKAGAFDSLG 883
|
|
| dnaE |
PRK07374 |
DNA polymerase III subunit alpha; Validated |
53-979 |
1.80e-132 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 168927 [Multi-domain] Cd Length: 1170 Bit Score: 429.91 E-value: 1.80e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 53 GDDMAVICGVklnvVDDPTYEhrarlakesercmeslvRDRSYCFTALIKNEQGYRDVCELMTLAN---KREQFYFvPRL 129
Cdd:PRK07374 64 GNEMYVINGS----IDDPQPK-----------------KEKRYHLVVLAKNATGYKNLVKLTTISHlngMRGRGIF-SRP 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 130 ALD-QLAAAYAKGNIILLTSDIGSVFQ-----RRDFAKIIGTLVTAGGRDNFYSVVYPHPTPFYDQINVRAMKVASALKI 203
Cdd:PRK07374 122 CIDkELLKQYSEGLIVSTACLGGEIPQailrgRPDVARDVAAWYKEVFGDDFYLEIQDHGSIEDRIVNVELVRIAKELGI 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 204 EPVAFYPAYYEAVDDADIKDIAHMVTNNIKIDQPHRLR------IPHQRDNAVNGRRHLLEAlkafSVRMDVPVTAAMAS 277
Cdd:PRK07374 202 KLIATNDAHYLSKNDVEAHDALLCVLTGKLISDEKRLRytgteyIKSEEEMLRLFRDHLDPE----VIQEAIANTVEVAE 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 278 TTQDTIIEAcTWRWhelpPALPKMADDEPAT-LMKLAVAGLRKRLTTKEFGYTPPAsehrvYVDRLKYEMDTLTRLGFCG 356
Cdd:PRK07374 278 KVEEYDILG-TYRM----PRFPIPEGHTAVSyLTEVTEQGLLKRLKLNSLDEIDEN-----YKERLSYELKIIEQMGFPT 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 357 YFLMVRDLMNHSRETGIPVGPGRGSSAGSLVAWCIGITNVDPIRHGLLFERFINPERLDLPDADLDFSQARRHEVIEYLN 436
Cdd:PRK07374 348 YFLVVWDYIRFAREQGIPVGPGRGSAAGSLVAYALGITNIDPVKNGLLFERFLNPERKSMPDIDTDFCIERRGEVIDYVT 427
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 437 ERYGEDYVAGIPNFTYLGAASALRDTARI----YGvDAADMA----VSK----EFKNLEDDSLSLEELREQLASlDKYAT 504
Cdd:PRK07374 428 RRYGEDKVAQIITFNRMTSKAVLKDVARVldipYG-EADRLAklipVVRgkpaKLKAMIGKESPSPEFREKYEK-DPRVK 505
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 505 KYPEafkAACKLQSLMRGFGRHAAGMIVAGVPLVERTPVELRGNARCIAfdkRY----CEAMGLIKLDVLGLATLDLLDS 580
Cdd:PRK07374 506 KWVD---MAMRIEGTNKTFGVHAAGVVIASDPLDELVPLQRNNDGQVIT---QYfmedIESLGLLKMDFLGLKNLTMIEK 579
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 581 AKRYIKESTGEDINLDAIPLDDRKVLDGFAAGYTQGVFQLESGPMRKLLKDLgggiEPMSFKTVVATTALFRPGPIQSGM 660
Cdd:PRK07374 580 TLELVEQSTGERIDPDNLPLDDEKTFELLARGDLEGIFQLESSGMRQVVRDL----KPSSLEDISSILALYRPGPLDAGL 655
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 661 LDDYVSVAKGFMAPQSLHPVLDELTAETNGVILYQEQTMNATRLLAGFTMAEADGVRKAIGKKDMEKMKSMGEKFVvqaq 740
Cdd:PRK07374 656 IPKFINRKHGREAIDFAHPLLEPILTETYGIMVYQEQIMKIAQDLAGYSLGQADLLRRAMGKKKVSEMQKHRGIFV---- 731
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 741 agwidvemedgttqrihraehfkceDGAlrtveealeagvklpmaavrvtgSQPGLSETKAKEIWDAFEKNGAYQFNKSH 820
Cdd:PRK07374 732 -------------------------EGA-----------------------SKRGVDEKVADELFDQMVLFAEYCFNKSH 763
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 821 PVAYSLISYQSMWLKTHYPAEFFAAALTILG--EDKHQGLVKDALTYGIHVLPPDVNVSSnrieIRTLEDGSQVLYApFS 898
Cdd:PRK07374 764 STAYGAVTYQTAYLKAHYPVAYMAALLTVNAgsSDKVQRYISNCNSMGIEVMPPDINRSG----IDFTPKGNRILFG-LS 838
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 899 AVKGCSENGCQAIMRAREKvGGKFESLEQFEEAVEKRacACNSRVRESLQKVGAFASIEPGSLPAT-----DP------E 967
Cdd:PRK07374 839 AVKNLGDGAIRNIIAARDS-DGPFKSLADLCDRLPSN--VLNRRSLESLIHCGALDAFSPNANRAQliadlDLvldwasS 915
|
970
....*....|..
gi 755429649 968 RLRDQAELMGNL 979
Cdd:PRK07374 916 RARDRASGQGNL 927
|
|
| dnaE |
PRK06920 |
DNA polymerase III subunit alpha; |
4-953 |
1.06e-121 |
|
DNA polymerase III subunit alpha;
Pssm-ID: 180749 [Multi-domain] Cd Length: 1107 Bit Score: 399.56 E-value: 1.06e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 4 LMVRTDFSLGESALKAENAVKIARDAGYTAVISADSMNIASVIPLQRAA-GDDMAVICGVKLNVVDDPTyehrarlakes 82
Cdd:PRK06920 6 LQCQTVFSLLKSACKIDELVVRAKELGYSSLAITDENVMYGVIPFYKACkKHGIHPIIGLTASIFSEEE----------- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 83 ercmeslvrDRSYCFTALIKNEQGYRDVCELM-TLANKREQFyfVPRLALdqlaAAYAKGNIILLTSDIGSVFQ------ 155
Cdd:PRK06920 75 ---------EKSYPLVLLAENEIGYQNLLKISsSIMTKSKEG--IPKKWL----AHYAKGLIAISPGKDGEIEQllledk 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 156 -------RRDFAKIIGtlvtaggrdNFYSVVYPHPTPFYDQINVRAMKVASALKIEPVAFYPAYYEAVDDADIKDIAHMV 228
Cdd:PRK06920 140 esqaeevARAYQNMFG---------NFYMSLQHHAIQDELLLQEKLPEFSNRVNIPVVATNDVRYINQSDALVHECLLSV 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 229 TNNIKIDQPH--RLRIPHQR----DNAVNGRRHLLEALK-----AFSVRMDVPVTAAmasttqdtiieactwRWHELPPA 297
Cdd:PRK06920 211 ESGTKMTDPDrpRLKTDQYYlkssDEMEALFSHVPEAIYntveiAERCRVEIPFHVN---------------QLPKFPVP 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 298 LPKMADDepaTLMKLAVAGLRKRlttkeFGyTPPasehRVYVDRLKYEMDTLTRLGFCGYFLMVRDLMNHSRETGIPVGP 377
Cdd:PRK06920 276 SNETADM---YLRRVCEEGLQKR-----YG-TPK----EVHINRLNHELNVISRMGFSDYFLIVWDFMKYAHENHILTGP 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 378 GRGSSAGSLVAWCIGITNVDPIRHGLLFERFINPERLDLPDADLDFSQARRHEVIEYLNERYGEDYVAGIPNFTYLGAAS 457
Cdd:PRK06920 343 GRGSAAGSLVSYVLEITDIDPIEYDLLFERFLNPERVTLPDIDIDFPDTRRDEMIRYVKDKYGQLRVAQIVTFGTLAAKA 422
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 458 ALRDTARIYGVDAADmavSKEFKNL--EDDSLSLEELREQLASLDKY---ATKYPEAFKAACKLQSLMRGFGRHAAGMIV 532
Cdd:PRK06920 423 AIRDIARVMGLPPRD---IDIFSKLipSKLGITLKDAYEESQSLREFiqgNLLHERVFEIAKRVEGLPRHTSIHAAGVIM 499
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 533 AGVPLVERTPV-ELRGNARCIAFDKRYCEAMGLIKLDVLGLATLDLLDSAKRYIKESTGEDINLDAIPLDDRKVLDGFAA 611
Cdd:PRK06920 500 SQEPLTGSVAIqEGHNDVYVTQYPADALEELGLLKMDFLGLRNLTLLENIIKFIEQKTGKEIDIRNLPLQDEKTFQLLGR 579
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 612 GYTQGVFQLESGPMRKLLKdlggGIEPMSFKTVVATTALFRPGPIQSGMLddYVSVAKGFMAPQSLHPVLDELTAETNGV 691
Cdd:PRK06920 580 GDTTGVFQLESSGMRNVLR----GLKPNEFEDIVAVNSLYRPGPMEQIPT--FIESKHGKRKIEYLHPDLKPILERTYGV 653
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 692 ILYQEQTMNATRLLAGFTMAEADGVRKAIGKKDMEKMKsmgekfvvqaqagwidvemedgtTQRihraEHFkcedgalrt 771
Cdd:PRK06920 654 IVYQEQIMQIASKLAGFSLGEADLLRRAVSKKNRDILD-----------------------QER----KHF--------- 697
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 772 VEEALeagvklpmaavrvtgsQPGLSETKAKEIWDAFEKNGAYQFNKSHPVAYSLISYQSMWLKTHYPAEFFAAALT--I 849
Cdd:PRK06920 698 VQGCL----------------QNGYDETSAEKIYDLIVRFANYGFNRSHAVAYSMIGYQLAYLKANYTLEFMTALLSsaI 761
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 850 LGEDKHQGLVKDALTYGIHVLPPDVNVSSNRIEIrtlEDGSqVLYApFSAVKGCSENGCQAIMRAREKvgGKFESLeqFE 929
Cdd:PRK06920 762 GNEDKIVQYIRETKRKGFHVLPPSLQRSGYNFQI---EGNA-IRYS-LLSIRNIGMATVTALYEEREK--KMFEDL--FE 832
|
970 980
....*....|....*....|....
gi 755429649 930 EAVEKRACACNSRVRESLQKVGAF 953
Cdd:PRK06920 833 FCLRMPSKFVTERNLEAFVWSGCF 856
|
|
| dnaE |
PRK07135 |
DNA polymerase III DnaE; Validated |
340-928 |
1.68e-118 |
|
DNA polymerase III DnaE; Validated
Pssm-ID: 235944 [Multi-domain] Cd Length: 973 Bit Score: 387.89 E-value: 1.68e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 340 DRLKYEMDTLTRLGFCGYFLMVRDLMNHSRETGIPVGPGRGSSAGSLVAWCIGITNVDPIRHGLLFERFINPERLDLPDA 419
Cdd:PRK07135 254 ERINYEYSVIKKLKFSNYFLIIWDFIKWARKNKISIGPGRGSASGSLVSYLLNITSVNPLKYDLLFERFLNPDRITMPDI 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 420 DLDFSQARRHEVIEYLNERYGEDYVAGIPNFTYLGAASALRDTARIYGVDAADM-AVSKEFKNleddSLSLEELREQLAS 498
Cdd:PRK07135 334 DIDIQDDRRDEVIDYIFEKYGYEHCATISTFQTLGAKSAIRDVGRMLGIPESDVnAISKLIPN----NQSLEEAYDKNKS 409
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 499 LDKY-----ATKYPEAFKAACKLQSLMRGFGRHAAGMIVAGVPLVERTPV-ELRGNARCIAFDKRYCEAMGLIKLDVLGL 572
Cdd:PRK07135 410 FFREliskgDPIYKKLYKIAKKLEGLPRQSGTHAAGIIISNKPITNYVPTfESKDNYNQVQYSMEFLEDFGLLKIDLLGL 489
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 573 ATLDLLDSAKRYI--KESTGEDINLDAIPLDDRKVLDGFAAGYTQGVFQLESGPMRKLLKDLggGIEpmSFKTVVATTAL 650
Cdd:PRK07135 490 KNLTIIKNIEEKInkELLFDHLINFNDLPIIDKKTNNLLSNGKTEGIFQLESPGMKSTIKKV--GID--SFEDIVAIISL 565
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 651 FRPGPIQsgMLDDYVSVAKGFMAPQSLHPVLDELTAETNGVILYQEQTMNATRLLAGFTMAEADGVRKAIGKKDMEKMKS 730
Cdd:PRK07135 566 YRPGPIQ--YIPIYAKNKKNPKNIEKIHPEYDEIVAPTYGIIIYQEQIMQIAQKVAGFSFAQADLLRRAISKKDETKLDK 643
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 731 MGEKFVvqaqagwidvemedgttqrihraehfkcedgalrtveealEAGVKLpmaavrvtgsqpGLSETKAKEIWDAFEK 810
Cdd:PRK07135 644 IKDKFI----------------------------------------EGGIKN------------GYSKKVLEKIYSLIEK 671
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 811 NGAYQFNKSHPVAYSLISYQSMWLKTHYPAEFFAAALTilGEDKHQ----GLVKDALTYGIHVLPPDVNVSSNrieiRTL 886
Cdd:PRK07135 672 FADYGFNKSHAVAYATLAYKMAYYKANYPLVFYSALIS--NSNGSQenikKYVKEAKNNGIKVYSPDINFSTE----NAV 745
|
570 580 590 600
....*....|....*....|....*....|....*....|..
gi 755429649 887 EDGSQvLYAPFSAVKGCSENGCQAIMRAREKvGGKFESLEQF 928
Cdd:PRK07135 746 FDNGK-IFLPLIMIKGLGSVAIKKIIDERNK-NGKYKNFFDF 785
|
|
| dnaE |
PRK05898 |
DNA polymerase III subunit alpha; |
206-957 |
5.78e-111 |
|
DNA polymerase III subunit alpha;
Pssm-ID: 135648 [Multi-domain] Cd Length: 971 Bit Score: 367.24 E-value: 5.78e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 206 VAFYPAYYEAVDDADIKDIAHMVTNNIKIDQphrLRIPHQRDNAvngrrHLLEALKAFSVRMDVpvtaamASTTQDTIIE 285
Cdd:PRK05898 138 IAFNSVFYANKNDKIVFNAMLAIKNDLKIDE---LKNCQDFDNN-----HFLNDNEAQSLFSPI------QLDNLNKVLN 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 286 ACTWRWHELPPALPKMAD----DEPATLMKLAVAGLRKRLTTKEfgytppASEHRVYVDRLKYEMDTLTRLGFCGYFLMV 361
Cdd:PRK05898 204 ELKVEIHDLPINIIKYDKqnsiISSEILKQLCISGLNKRLNAND------GQVKKIYVKRLKYELDIINEKQFDDYFLIV 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 362 RDLMNHSRETGIPVGPGRGSSAGSLVAWCIGITNVDPIRHGLLFERFINPERLDLPDADLDFSQARRHEVIEYLNERYGE 441
Cdd:PRK05898 278 YDFINFAKSNGIIIGPGRGSAAGSLIAYLLHITDIDPIKYNLIFERFLNPTRKSMPDIDTDIMDERRDEVVEYLFEKYGN 357
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 442 DYVAGIPNFTYLGAASALRDTARIYGVDAA--DMAVSKEFKNLEDDslsLEELREQLASLDKYATKYPEAFKAACKLQSL 519
Cdd:PRK05898 358 DHVAHIITFQRIKAKMAIRDVGRILGIDLKviDKICKNIKPDYEED---LDLAIKKNTILKEMYVLHKELFDLAKKIINA 434
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 520 MRGFGRHAAGMIVAGVPLVERTPVELRGNARCIA-FDKRYCEAMGLIKLDVLGLATLDLLDSAKRYIKESTGEDINLDAI 598
Cdd:PRK05898 435 PRQIGTHAAGVVLSNSLLTNIIPIQLGINDRPLSqYSMEYLERFGLIKMDLLGLKNLTIIDNVLKLIKENQNKKIDLFNI 514
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 599 PLDDRKVLDGFAAGYTQGVFQLESGPMRKLLKDlgggIEPMSFKTVVATTALFRPGPIQSgmLDDYVSVAKGFMAPQSLH 678
Cdd:PRK05898 515 NLNDKNVFEDLAKGRTNGIFQLESPGMKKVLKK----VKPQNIEDISIVSALFRPGPQQN--IKTFVERRFKREEFSYWN 588
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 679 PVLDELTAETNGVILYQEQTMNATRLLAGFTMAEADGVRKAIGKKDmekmksmgEKFVVQAQAGWIdvemedgttqrihr 758
Cdd:PRK05898 589 EATKKILEPTHGIIVYQEQVINLVKTIANFDIATADNFRRAISKKD--------EKILIQLKKDFI-------------- 646
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 759 aehfkceDGALRTveealeagvklpmaavrvtgsqpGLSETKAKEIWDAFEKNGAYQFNKSHPVAYSLISYQSMWLKTHY 838
Cdd:PRK05898 647 -------EGALKN-----------------------NYKQPLVNQIFEYIFSFADYGFNHSHSLAYSYISYWMAYLKHYY 696
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 839 PAEFFAAALTILGEDKHQGL--VKDALTYGIHVLPPDVNVSSNRIEIRTledGSQVLYAPFSAVKGCSENGCQAIMRARE 916
Cdd:PRK05898 697 PLEFLSILLSHTSASKDKLLsyLNEAKEFNISIKKPDINYSSNSFVLDT---QKQIIRFGFNTIKGFGDELLKKIKSALQ 773
|
730 740 750 760
....*....|....*....|....*....|....*....|..
gi 755429649 917 KvggkfESLEQFEEAVEKRACACNS-RVRESLQKVGAFASIE 957
Cdd:PRK05898 774 N-----KTFSDFISYIDALKKNNVSlSNIEILINVGTFDSFK 810
|
|
| dnaE |
PRK07279 |
DNA polymerase III DnaE; Reviewed |
298-958 |
3.25e-101 |
|
DNA polymerase III DnaE; Reviewed
Pssm-ID: 180917 [Multi-domain] Cd Length: 1034 Bit Score: 342.01 E-value: 3.25e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 298 LPKMADDEPAT--LMKLAVAGLRKRLTTKEfgytppasehrVYVDRLKYEMDTLTRLGFCGYFLMVRDLMNHSRETGIPV 375
Cdd:PRK07279 229 LPRFNRDRPAVeeLRELAELGLKEKGLWSS-----------PYQERLDKELSVIHDMGFDDYFLIVWDLLRFGRSQGYYM 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 376 GPGRGSSAGSLVAWCIGITNVDPIRHGLLFERFINPERLDLPDADLDFSQARRHEVIEYLNERYGEDYVAGIPNFTYLGA 455
Cdd:PRK07279 298 GMGRGSAAGSLVAYALDITGIDPVKHNLLFERFLNKERYSMPDIDIDLPDIYRSEFLRYVRNRYGSDHSAQIVTFSTFGA 377
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 456 ASALRDTARIYGVDAADM-AVSKE--FKnledDSLSLE-----ELREQLASldkyATKYPEAFKAACKLQSLMRGFGRHA 527
Cdd:PRK07279 378 KQAIRDVFKRFGVPEYELsNLTKKisFR----DSLASVyekniSFRQIINS----KLEYQKAFEIAKRIEGNPRQTSIHA 449
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 528 AGMIVAGVPLVERTPVELRGNARCIAFDKRYCEAMGLIKLDVLGLATLDLLDSAKRYIKESTGEDINLDAIPLDDRKVLD 607
Cdd:PRK07279 450 AGVVMSDDDLTNHIPLKYGDDMMITQYDAHAVEANGLLKMDFLGLRNLTFVQKMQEKVAKDYGIHIDIEAIDLEDKETLA 529
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 608 GFAAGYTQGVFQLESGPMRKLLKDlgggIEPMSFKTVVATTALFRPGPiqSGMLDDYVSVAKGFMAPQSLHPVLDELTAE 687
Cdd:PRK07279 530 LFAAGDTKGIFQFEQPGAINLLKR----IKPVCFEDIVATTSLNRPGA--SDYTDNFVKRRHGQEKVDLIDPVIAPILEP 603
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 688 TNGVILYQEQTMNATRLLAGFTMAEADGVRKAIGKKDMEKMKSMGEKFVvqaqagwidvemedgttqrihraehfkceDG 767
Cdd:PRK07279 604 TYGIMLYQEQVMQIAQVFAGFSLGKADLLRRAMSKKNASEMQKMEEDFL-----------------------------QG 654
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 768 ALrtveealeagvklpmaavrvtgsQPGLSETKAKEIWDAFEKNGAYQFNKSHPVAYSLISYQSMWLKTHYPAEFFaaal 847
Cdd:PRK07279 655 AL-----------------------ELGHSEEKARELFDRMEKFAGYGFNRSHAFAYSALAFQLAYFKAHYPAVFY---- 707
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 848 TILGEDKHQGLVKDALTYGIHVLPPDVnvssNRIEIRTLEDGSQVlYAPFSAVKGCSENGCQAIMRAREkvggkFESLEQ 927
Cdd:PRK07279 708 DIMLNYSSSDYITDALEFGFEVAKLSI----NTIPYHDKIENKKI-YLGLKNIKGLPRDLAYWIIENRP-----FSSIED 777
|
650 660 670
....*....|....*....|....*....|....
gi 755429649 928 FEEAVEKracacNSRVRESLQ---KVGAFASIEP 958
Cdd:PRK07279 778 FLTRLPE-----NYQKKEFLEpliKIGLFDSFEK 806
|
|
| dnaE2 |
PRK05672 |
error-prone DNA polymerase; Validated |
98-971 |
8.91e-99 |
|
error-prone DNA polymerase; Validated
Pssm-ID: 235553 [Multi-domain] Cd Length: 1046 Bit Score: 335.67 E-value: 8.91e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 98 TALIKNEQGYRDVCELMTLANKREQfYFVPRLALDQLAAAYAKGNIILLTSDIGSVFQ------RRDFAKIIGTLVTAGG 171
Cdd:PRK05672 83 LVLARDREGYGRLSRLITRARLRAG-KGEYRLDLDDLAEPAGGHWAILTGCRKGFVILalpyggDAAALAALAALLDAFF 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 172 RDNFYSVVYPHPTPFYDQINVRAMKVASALKIEPVAFYPAYYEAVDDADIkdiaHMVTNNIKIDQP-----HRLriphqr 246
Cdd:PRK05672 162 ADRVWLELTLHGRPDDDRRNARLAALAARAGVPLVATGDVHMHHRSRRRL----QDAMTAIRARRSlaeagGWL------ 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 247 dnAVNGRRHL---LEALKAFSVRMDVpVTAAMAsttqdtIIEACTWRWHELPPALPKmaDDEPAT------LMKLAVAGL 317
Cdd:PRK05672 232 --APNGERHLrsgAEMARLFPDYPEA-LAETVE------LAERCAFDLDLLAYEYPD--EPVPAGhtpaswLRQLTEAGA 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 318 RKRlttkefgYTPPASEhRVYvDRLKYEMDTLTRLGFCGYFLMVRDLMNHSRETGIpVGPGRGSSAGSLVAWCIGITNVD 397
Cdd:PRK05672 301 ARR-------YGPGIPP-KAR-AQIEHELALIAELGYEGYFLTVHDIVRFARSQGI-LCQGRGSAANSAVCYALGITEVD 370
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 398 PIRHGLLFERFINPERLDLPDADLDFSQARRHEVIEYLNERYGEDYVAGIPN-FTYLGaASALRDTARIYGVDA--ADmA 474
Cdd:PRK05672 371 PVQSGLLFERFLSPERDEPPDIDVDFEHDRREEVIQYVYRRYGRDRAAQVANvITYRP-RSAVRDVAKALGLSPgqVD-A 448
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 475 VSKEFKNLEDDSLSLEELREqlASLDKYATKYPEAFKAACKLQSLMRGFGRHAAGMIVAGVPLVERTPVElrgNAR---- 550
Cdd:PRK05672 449 WAKQVSRWSGSADDLQRLRQ--AGLDPESPIPRRVVELAAQLIGFPRHLSQHSGGFVICDRPLARLVPVE---NAAmegr 523
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 551 -CIAFDKRYCEAMGLIKLDVLGLATLDLLDSAKRYIKESTGEDINLDAIPLDDRKVLDGFAAGYTQGVFQLES-GPMRKL 628
Cdd:PRK05672 524 sVIQWDKDDCAAVGLVKVDVLALGMLSALHRAFDLIAEHRGRRLTLASIPLDDPAVYDMLCRADSVGVFQVESrAQMAML 603
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 629 --LKdlgggiePMSFKTVVATTALFRPGPIQSGMLDDYVSVAKGFMAPQSLHPVLDELTAETNGVILYQEQTMNATRLLA 706
Cdd:PRK05672 604 prLR-------PRTFYDLVVEVAIVRPGPIQGGMVHPYLRRRNGQEPVTYPHPELEKVLERTLGVPLFQEQVMQIAIDAA 676
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 707 GFTMAEADGVRKAIG-KKDMEKMKSMGEKFVvqaqagwidvemeDGTTQRihraehfkcedgalrtveealeagvklpma 785
Cdd:PRK05672 677 GFTPGEADQLRRAMAaWRRKGRLERLRERLY-------------DGMLAR------------------------------ 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 786 avrvtgsqpGLSETKAKEIWDAFEKNGAYQFNKSHPVAYSLISYQSMWLKTHYPAEFFAAALTI--LGEDKHQGLVKDAL 863
Cdd:PRK05672 714 ---------GYTGEFADRIFEQIKGFGEYGFPESHAASFAKLVYASSWLKCHHPAAFCAALLNSqpMGFYSPQQLVQDAR 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 864 TYGIHVLPPDVNVSSNRIeirTLEDGSQVLYA---PFSAVKGCSENGCQAIMRAREKvgGKFESLEQFeeaveKRACACN 940
Cdd:PRK05672 785 RHGVEVLPVDVNASGWDA---TLEPLPDGGPAvrlGLRLVRGLGEEAAERIVAARAR--GPFTSVEDL-----ARRAGLD 854
|
890 900 910 920
....*....|....*....|....*....|....*....|
gi 755429649 941 SRVRESLQKVGAFASI---------EPGSLPATDPERLRD 971
Cdd:PRK05672 855 RRQLEALADAGALRSLggdrrqalwAAGAAATERLDLLPG 894
|
|
| PRK09532 |
PRK09532 |
DNA polymerase III subunit alpha; Reviewed |
91-773 |
3.12e-94 |
|
DNA polymerase III subunit alpha; Reviewed
Pssm-ID: 181933 [Multi-domain] Cd Length: 874 Bit Score: 319.38 E-value: 3.12e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 91 RDRSYCFTALIKNEQGYRDVCELMTLAN----KREQFYFVPRLALDQLAAaYAKGNIILLTSDIGSVFQ-----RRDFAK 161
Cdd:PRK09532 79 RRRKYHQVVLAKNTQGYKNLVKLTTISHlqgvQGKGIFARPCINKELLEQ-YHEGLIVTSACLGGEIPQailsgRPDAAR 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 162 IIGTLVTAGGRDNFYSVVYPHPTPFYDQINVRAMKVASALKIEPVAFYPAYYEAVDDADIKDIAHMVTNNIKIDQPHRLR 241
Cdd:PRK09532 158 KVAKWYKKLFGDDFYLEIQDHGSQEDRIVNVEIVKIARELGIKIIATNDSHFISCYDVEAHDALLCIQTGKLITEDKRLR 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 242 iphqrdnaVNGRRHLL---EALKAFSVRMDVPVTAAMASTTQDTI--IEACTWRWHELPPALPKMADDEPATLMK-LAVA 315
Cdd:PRK09532 238 --------YSGTEYLKsaeEMRLLFRDHLPDDVIAEAIANTLEVAdkIEPYNILGEPRIPNYPVPSGHTPDTYVEeVAWQ 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 316 GLRKRLTTKEFGYTPPasehrVYVDRLKYEMDTLTRLGFCGYFLMVRDLMNHSRETGIPVGPGRGSSAGSLVAWCIGITN 395
Cdd:PRK09532 310 GLLERLNCKSRSEVEP-----VYKERLEYELKMLQQMGFSTYFLVVWDYIKYARDNNIPVGPGRGSAAGSLVAYCLKITN 384
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 396 VDPIRHGLLFERFINPERLDLPDADLDFSQARRHEVIEYLNERYGEDYVAGIPNFTYLGAASALRDTARI----YGvDAA 471
Cdd:PRK09532 385 IDPVHHGLLFERFLNPERKSMPDIDTDFCIERRDEMIKYVTEKYGEDRVAQIITFNRMTSKAVLKDVARVldipYG-EAD 463
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 472 DMA----VSK----EFKNLEDDSLSLEELREQLASlDKYATKYpeaFKAACKLQSLMRGFGRHAAGMIVAGVPLVERTPV 543
Cdd:PRK09532 464 KMAklipVSRgkptKLKVMISDETPEPEFKEKYDN-DPRVRRW---LDMAIRIEGTNKTFGVHAAGVVISSEPLDEIVPL 539
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 544 ELRGNARCIAfdkRY----CEAMGLIKLDVLGLATLDLLDSAKRYIKESTGEDINLDAIPLDDRKVLDG----------- 608
Cdd:PRK09532 540 QKNNDGAVIT---QYfmedLESLGLLKMDFLGLRNLTTIQKTADLIKENRGVEIDLDQLPLDERKALKIlakgeakklpk 616
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 609 --------FAAGYTQGVFQLESGPMRKLLKDLG-GGIEPMSfktvvATTALFRPGPIQSGMLDDYVSVAKGFMAPQSLHP 679
Cdd:PRK09532 617 dvqkthklLERGDLEGIFQLESSGMKQIVRDLKpSNIEDIS-----SILALYRPGPLDAGLIPKFINRKHGREPIDYEHQ 691
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 680 VLDELTAETNGVILYQEQTMNATRLLAGFTMAEADGVRKAIGKKDMEKMKSMGEKFVVQAQAGWIDVEM-EDGTTQRIHR 758
Cdd:PRK09532 692 LLEPILNETYGVLVYQEQIMKMAQDLAGYSLGEADLLRRAMGKKKISEMQKHREKFIDGAAKNGVSKKVaENLFDQMVKF 771
|
730
....*....|....*
gi 755429649 759 AEHFKCEDGALRTVE 773
Cdd:PRK09532 772 AEYCLSYDTEVLTVE 786
|
|
| DNA_pol3_alpha |
pfam07733 |
Bacterial DNA polymerase III alpha NTPase domain; |
309-571 |
5.20e-85 |
|
Bacterial DNA polymerase III alpha NTPase domain;
Pssm-ID: 400196 [Multi-domain] Cd Length: 259 Bit Score: 275.15 E-value: 5.20e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 309 LMKLAVAGLRKRLttkefgytpPASEHRVYVDRLKYEMDTLTRLGFCGYFLMVRDLMNHSRETGIPVGPGRGSSAGSLVA 388
Cdd:pfam07733 3 LRKLVEEGLKERY---------GEGLPEEYQERLEYELNVIIKMGFAGYFLIVWDLVKWAKDNGILVGPGRGSAAGSLVA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 389 WCIGITNVDPIRHGLLFERFINPERLDLPDADLDFSQARRHEVIEYLNERYGEDYVAGIPNFTYLGAASALRDTARIYGV 468
Cdd:pfam07733 74 YLLGITEVDPLKHDLLFERFLNPERVSMPDIDIDFEDERREEVIDYVKEKYGRDRVAQIATFGTYAAKSAIRDVGRALGL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 469 DAADM-AVSKEFKNLEDDSLSLEELREQLASLDKYATKYPEAFKAACKLQSLMRGFGRHAAGMIVAGVPLVERTPVELRG 547
Cdd:pfam07733 154 PYDEIdRLAKLIPFELGILEKALEEEPELKELIESDPEVKRLIELAKKLEGLPRHTGQHAGGVVISPDPLTDFVPLYKAD 233
|
250 260
....*....|....*....|....*.
gi 755429649 548 --NARCIAFDKRYCEAMGLIKLDVLG 571
Cdd:pfam07733 234 ddDRPVTQFDKDDLEDLGLLKMDFLG 259
|
|
| DNA_pol3_finger |
pfam17657 |
Bacterial DNA polymerase III alpha subunit finger domain; |
574-741 |
2.55e-52 |
|
Bacterial DNA polymerase III alpha subunit finger domain;
Pssm-ID: 407553 [Multi-domain] Cd Length: 166 Bit Score: 180.81 E-value: 2.55e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 574 TLDLLDSAKRYIKESTGEDINLDAIPLDDRKVLDGFAAGYTQGVFQLESGPMRKLLKDLgggiEPMSFKTVVATTALFRP 653
Cdd:pfam17657 1 TLTIIRDALDLIKENRGIGIDLATIPLDDPKTYKLLSSGDTLGVFQFESRGMRQMLKRL----KPDTFEDLVALSALYRP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 654 GPIQSGMLDDYVSVAKGFMAPQSLHPVLDELTAETNGVILYQEQTMNATRLLAGFTMAEADGVRKAIGKKDMEKMKSMGE 733
Cdd:pfam17657 77 GPMQGGNVDDYIKRKHGKEKIEYPHPDLEPILKETYGVIVYQEQVMQIAQILAGFSLGEADLLRRAMGKKKPEEMEKLRE 156
|
....*...
gi 755429649 734 KFVVQAQA 741
Cdd:pfam17657 157 KFIEGAKE 164
|
|
| PRK07373 |
PRK07373 |
DNA polymerase III subunit alpha; Reviewed |
816-958 |
9.49e-24 |
|
DNA polymerase III subunit alpha; Reviewed
Pssm-ID: 236003 [Multi-domain] Cd Length: 449 Bit Score: 105.91 E-value: 9.49e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 816 FNKSHPVAYSLISYQSMWLKTHYPAEFFAAALTILG--EDKHQGLVKDALTYGIHVLPPDVNvssnrieiRTLED----G 889
Cdd:PRK07373 38 FNKSHSTAYAYVTYQTAYLKANYPVEYMAALLTANSgnQDKVQKYRENCQKMGIEVEPPDIN--------RSGKDftpvG 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755429649 890 SQVLYApFSAVKGCSENGCQAIMRAREkVGGKFESLEQFEEAVEKRacACNSRVRESLQKVGAFASIEP 958
Cdd:PRK07373 110 EKILFG-LSAVRNLGEGAIESILKARE-EGGEFKSLADFCDRVDLR--VVNRRALETLIYCGAFDKIEP 174
|
|
| PHP_PolIIIA |
cd07431 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; ... |
4-150 |
2.43e-19 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such activity has not been found. It has been shown that the PHP domain of PolIIIA has a trinuclear metal complex and is capable of proofreading activity.
Pssm-ID: 213986 [Multi-domain] Cd Length: 179 Bit Score: 86.49 E-value: 2.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 4 LMVRTDFSLGESALKAENAVKIARDAGYTAVISADSMNIASVIPLQRAAGD-DMAVICGVKLNVVDDptyehrarlakes 82
Cdd:cd07431 3 LHVHSSYSLLDSAIRPEDLVARAKELGYSALALTDRNVLYGAVRFYKACKKaGIKPIIGLELTVEGD------------- 69
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755429649 83 ercmeslvrDRSYCFTALIKNEQGYRDVCELMTLANKREQFYFVPRLALDQLaAAYAKGNIILLTSDI 150
Cdd:cd07431 70 ---------GEPYPLLLLAKNNEGYQNLLRLSTAAMLGEEKDGVPYLDLEEL-AEAASGLLVVLLGPL 127
|
|
| HHH_6 |
pfam14579 |
Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain. |
866-958 |
6.11e-13 |
|
Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain.
Pssm-ID: 434050 [Multi-domain] Cd Length: 88 Bit Score: 65.19 E-value: 6.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 866 GIHVLPPDVNVSSNRIeirTLEDGsQVLYaPFSAVKGCSENGCQAIMRAREkvGGKFESLEQFEEAVEKRacaCNSRVRE 945
Cdd:pfam14579 1 GIEVLPPDINRSDWDF---TVEGG-GIRL-GLGAIKGLGEAAAERIVEERE--NGPFKSLEDFARRVDLK---LNKRVLE 70
|
90
....*....|...
gi 755429649 946 SLQKVGAFASIEP 958
Cdd:pfam14579 71 ALIKAGAFDSLGG 83
|
|
| PHP_PolIIIA_DnaE1 |
cd07433 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
4-224 |
4.49e-09 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes.
Pssm-ID: 213988 [Multi-domain] Cd Length: 277 Bit Score: 58.64 E-value: 4.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 4 LMVRTDFSLGESALKAENAVKIARDAGYTAVISADSMNI-ASVIPLQRAAGDDMAVICGVKLNVVDDptyehrarlakes 82
Cdd:cd07433 5 LRVHSEYSLLDGAVRIKKLVKLAKEDGMPALAITDLSNLfGAVKFYKAASKAGIKPIIGADLNVANP------------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 83 ercmesLVRDRSYCFTALIKNEQGYRDVCELMTLANKREQFYFVPRLALDQLaAAYAKGnIILLT----SDIGSVFQRRD 158
Cdd:cd07433 72 ------DDADEPFRLTLLAQNEQGYKNLTELISRAYLEGQRNGGPHIKLEWL-AEYSEG-LIALSggrdGDIGQLLLEGN 143
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755429649 159 FAKI---IGTLVTAGGrDNFYSVVYPHPTPFYDQINVRAMKVASALKIEPVAFYPAYYEAVDDADIKDI 224
Cdd:cd07433 144 PDLAealLQFLKKIFP-DRFYLELQRHGRPEEEAYEHALIDLAYELGLPLVATNDVRFLKPEDFEAHEA 211
|
|
| PHP_PolIIIA_DnaE3 |
cd12113 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
4-243 |
7.03e-09 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, the PolIIIA PHP exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such an activity has not been found. It has been shown that the PHP of PolIIIA has a trinuclear metal complex and is capable of proofreading activity. Bacterial genome replication and DNA repair mechanisms is related to the GC content of its genomes. There is a correlation between GC content variations and the dimeric combinations of PolIIIA subunits. Eubacteria can be grouped into different GC variable groups: the full-spectrum or dnaE1 group, the high-GC or dnaE2-dnaE1 group, and the low GC or polC-dnaE3 group.
Pssm-ID: 213997 [Multi-domain] Cd Length: 283 Bit Score: 58.22 E-value: 7.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 4 LMVRTDFSLGESALKAENAVKIARDAGYTAVISADSMNIASVIPLQRAAgddMAV----ICGVKLNVVDDPtyehraRLA 79
Cdd:cd12113 5 LHVHTEYSLLDGAIRIKDLVKRAKELGMPALAITDHGNMFGAIEFYKAA---KKAgikpIIGCEVYVAPGS------RFD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 80 KESERcmeslVRDRSYCFTALIKNEQGYRDVCELMTLANKrEQFYFVPRLALDQLaAAYAKGnIILLTSDIGSVFQRR-- 157
Cdd:cd12113 76 KKDKK-----GDKRYYHLVLLAKNEEGYRNLMKLVSLAYL-EGFYYKPRIDKELL-AKYSEG-LIALSACLAGEIPQLll 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 158 --DFA---KIIGTLVTAGGRDNFYSVVYPHPTPFYDQINVRAMKVASALKIEPVAFYPAYYEAVDDADIKDIAHMVTNNI 232
Cdd:cd12113 148 ngDEEearEAALEYRDIFGKDNFYLELQDHGLPEQKKVNEGLIELAKELGIPLVATNDVHYLNKEDAEAHDVLLCIQTGK 227
|
250
....*....|.
gi 755429649 233 KIDQPHRLRIP 243
Cdd:cd12113 228 TLDDPNRMRFD 238
|
|
| PHP |
pfam02811 |
PHP domain; The PHP (Polymerase and Histidinol Phosphatase) domain is a putative ... |
6-176 |
4.13e-08 |
|
PHP domain; The PHP (Polymerase and Histidinol Phosphatase) domain is a putative phosphoesterase domain.
Pssm-ID: 460705 [Multi-domain] Cd Length: 171 Bit Score: 54.09 E-value: 4.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 6 VRTDFSLGESALKAENAVKIARDAGYTAVISADSMNIASVIPLQRAAGD-DMAVICGVKLNVVDDPTYEHRArlakeser 84
Cdd:pfam02811 4 VHSEYSLLDGAARIEELVKRAKELGMPAIAITDHGNLFGAVEFYKAAKKaGIKPIIGCEVYVAPGSREETEK-------- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755429649 85 cmeslVRDRSYCFTALIKNEQGYRDVCELMTLANKReqfYFVPRLALDQLaAAYAKGnIILLTSDI-GSVFQRR------ 157
Cdd:pfam02811 76 -----LLAKYFDLVLLAVHEVGYKNLIKLSSRAYLE---GFKPRIDKELL-EEYFEG-LIALSGCVlGHLDLILlapgdy 145
|
170 180
....*....|....*....|
gi 755429649 158 -DFAKIIGTLVTAGGRDNFY 176
Cdd:pfam02811 146 eEAEELAEEYLEIFGEDGFY 165
|
|
| |
