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Conserved domains on  [gi|805399995|gb|AKB50515|]
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Orotate phosphoribosyltransferase related protein [Methanosarcina barkeri str. Wiesmoor]

Protein Classification

similar to PyrE-like protein( domain architecture ID 10787126)

protein similar to PyrE-like protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PyrE2 COG0856
Orotate phosphoribosyltransferase homolog [Nucleotide transport and metabolism];
43-246 2.41e-117

Orotate phosphoribosyltransferase homolog [Nucleotide transport and metabolism];


:

Pssm-ID: 440617 [Multi-domain]  Cd Length: 201  Bit Score: 333.36  E-value: 2.41e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995  43 MKNIEDLIQKAVELQSNGLVTGQIADELNVSRETVTWLLTRSKKEVAAPAPKDISVNWSNIGKSATRLHYISLALCDMVL 122
Cdd:COG0856    1 MKNIDELIEKAAELKSKGLSTGEIADELNVSRETATWLLTRAKKGSGEPAPKDIHVDWSSIGRSSNRLRYIAQAMADMLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 123 ETLeeTNAEVDVVVGVAASGIPLASMMANELGADFALYHSRKGQDvVQPGQKGTISRNFGGVAGKNCVIVDDVITTGSTT 202
Cdd:COG0856   81 EEL--GDEEVDLVVGIAKSGVPLATLVAEELGTELAIYHPAKHQW-EIEDLGGSFSRNFASVEGKRCVIVDDVITSGTTM 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 805399995 203 MEVIEQLREMGAKPRAVAVLVDKKGADMIANVPIRSLVRIVRLD 246
Cdd:COG0856  158 TETIEAIREHGGEPVACVVLVDKRGIDEIDGVPVYSLIRVVRVG 201
 
Name Accession Description Interval E-value
PyrE2 COG0856
Orotate phosphoribosyltransferase homolog [Nucleotide transport and metabolism];
43-246 2.41e-117

Orotate phosphoribosyltransferase homolog [Nucleotide transport and metabolism];


Pssm-ID: 440617 [Multi-domain]  Cd Length: 201  Bit Score: 333.36  E-value: 2.41e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995  43 MKNIEDLIQKAVELQSNGLVTGQIADELNVSRETVTWLLTRSKKEVAAPAPKDISVNWSNIGKSATRLHYISLALCDMVL 122
Cdd:COG0856    1 MKNIDELIEKAAELKSKGLSTGEIADELNVSRETATWLLTRAKKGSGEPAPKDIHVDWSSIGRSSNRLRYIAQAMADMLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 123 ETLeeTNAEVDVVVGVAASGIPLASMMANELGADFALYHSRKGQDvVQPGQKGTISRNFGGVAGKNCVIVDDVITTGSTT 202
Cdd:COG0856   81 EEL--GDEEVDLVVGIAKSGVPLATLVAEELGTELAIYHPAKHQW-EIEDLGGSFSRNFASVEGKRCVIVDDVITSGTTM 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 805399995 203 MEVIEQLREMGAKPRAVAVLVDKKGADMIANVPIRSLVRIVRLD 246
Cdd:COG0856  158 TETIEAIREHGGEPVACVVLVDKRGIDEIDGVPVYSLIRVVRVG 201
PRK02277 PRK02277
orotate phosphoribosyltransferase-like protein; Provisional
 43-246 2.83e-117

orotate phosphoribosyltransferase-like protein; Provisional


Pssm-ID: 235023 [Multi-domain]  Cd Length: 200  Bit Score: 332.99  E-value: 2.83e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995  43 MKNIEDLIQKAVELQSNGLVTGQIADELNVSRETVTWLLTRSKKEVAAPAPKDISVNWSNIGKSATRLHYISLALCDMvl 122
Cdd:PRK02277   1 MKNIEELIEKAAELKNKGLSTGEIADELNVSRETATWLLTRAKKLEKAPAPKDIHIDWSSIGSSSSRLRYIASAMADM-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 123 etLEETNAEVDVVVGVAASGIPLASMMANELGADFALYHSRKGQDVVQPGQKGTISRNFGGVAGKNCVIVDDVITTGSTT 202
Cdd:PRK02277  79 --LEKEDEEVDVVVGIAKSGVPLATLVADELGKDLAIYHPKKWDHGEGEKKTGSFSRNFASVEGKRCVIVDDVITSGTTM 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 805399995 203 MEVIEQLREMGAKPRAVAVLVDKKGADMIANVPIRSLVRIVRLD 246
Cdd:PRK02277 157 KETIEYLKEHGGKPVAVVVLIDKSGIDEIDGVPVYSLIRVVRVD 200
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 117-240 9.44e-25

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 95.16  E-value: 9.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 117 LCDMVLETLEETNAEVDVVVGVAASGIPLASMMANELGADFALYH-SRKGQDVVQPGQKGTISRNFGGVAGKNCVIVDDV 195
Cdd:cd06223    1 AGRLLAEEIREDLLEPDVVVGILRGGLPLAAALARALGLPLAFIRkERKGPGRTPSEPYGLELPLGGDVKGKRVLLVDDV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 805399995 196 ITTGSTTMEVIEQLREMGAKPRAVAVLVDKK-GADMIANVPIRSLV 240
Cdd:cd06223   81 IATGGTLLAAIELLKEAGAKVVGVAVLLDKPeGGARELASPGDPVY 126
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 123-225 3.90e-15

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 70.47  E-value: 3.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995  123 ETLEETNAEVDVVVGVAASGIPLASMMANELGADFA-LYHSRKGQDVvqpGQKGTISRNFGGVAGKNCVIVDDVITTGST 201
Cdd:pfam00156  21 QINEDYGGKPDVVVGILRGGLPFAGILARRLDVPLAfVRKVSYNPDT---SEVMKTSSALPDLKGKTVLIVDDILDTGGT 97

                          90       100
                  ....*....|....*....|....
gi 805399995  202 TMEVIEQLREMGAKPRAVAVLVDK 225
Cdd:pfam00156  98 LLKVLELLKNVGPKEVKIAVLIDK 121
pyrE TIGR00336
orotate phosphoribosyltransferase; Orotate phosphoribosyltransferase (OPRTase) is involved in ...
 131-226 4.68e-10

orotate phosphoribosyltransferase; Orotate phosphoribosyltransferase (OPRTase) is involved in the biosynthesis of pyrimidine nucleotides. Alpha-D-ribosyldiphosphate 5-phosphate (PRPP) and orotate are utilized to form pyrophosphate and orotidine 5'-monophosphate (OMP) in the presence of divalent cations, preferably Mg2+. In a number of eukaryotes, this protein is fused to a domain that catalyses the reaction (EC 4.1.1.23). The combined activity of EC 2.4.2.10 and EC 4.1.1.23 is termed uridine 5'-monophosphate synthase. The conserved Lys (K) residue at position 101 of the seed alignment has been proposed as the active site for the enzyme. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 129436 [Multi-domain]  Cd Length: 173  Bit Score: 57.05  E-value: 4.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995  131 EVDVVVGVAASGIPLASM----MANELGADFALYHSRKGQDVvqpGQKGTISrnfGGVA-GKNCVIVDDVITTGSTTMEV 205
Cdd:TIGR00336  54 EFDVIAGPALGGIPIATAvsvkLAKPGGDIPLCFNRKEAKDH---GEGGNIE---GELLeGDKVVVVEDVITTGTSILEA 127

                          90       100
                  ....*....|....*....|.
gi 805399995  206 IEQLREMGAKPRAVAVLVDKK 226
Cdd:TIGR00336 128 VEIIQAAGGQVAGVIIAVDRQ 148
 
Name Accession Description Interval E-value
PyrE2 COG0856
Orotate phosphoribosyltransferase homolog [Nucleotide transport and metabolism];
43-246 2.41e-117

Orotate phosphoribosyltransferase homolog [Nucleotide transport and metabolism];


Pssm-ID: 440617 [Multi-domain]  Cd Length: 201  Bit Score: 333.36  E-value: 2.41e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995  43 MKNIEDLIQKAVELQSNGLVTGQIADELNVSRETVTWLLTRSKKEVAAPAPKDISVNWSNIGKSATRLHYISLALCDMVL 122
Cdd:COG0856    1 MKNIDELIEKAAELKSKGLSTGEIADELNVSRETATWLLTRAKKGSGEPAPKDIHVDWSSIGRSSNRLRYIAQAMADMLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 123 ETLeeTNAEVDVVVGVAASGIPLASMMANELGADFALYHSRKGQDvVQPGQKGTISRNFGGVAGKNCVIVDDVITTGSTT 202
Cdd:COG0856   81 EEL--GDEEVDLVVGIAKSGVPLATLVAEELGTELAIYHPAKHQW-EIEDLGGSFSRNFASVEGKRCVIVDDVITSGTTM 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 805399995 203 MEVIEQLREMGAKPRAVAVLVDKKGADMIANVPIRSLVRIVRLD 246
Cdd:COG0856  158 TETIEAIREHGGEPVACVVLVDKRGIDEIDGVPVYSLIRVVRVG 201
PRK02277 PRK02277
orotate phosphoribosyltransferase-like protein; Provisional
 43-246 2.83e-117

orotate phosphoribosyltransferase-like protein; Provisional


Pssm-ID: 235023 [Multi-domain]  Cd Length: 200  Bit Score: 332.99  E-value: 2.83e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995  43 MKNIEDLIQKAVELQSNGLVTGQIADELNVSRETVTWLLTRSKKEVAAPAPKDISVNWSNIGKSATRLHYISLALCDMvl 122
Cdd:PRK02277   1 MKNIEELIEKAAELKNKGLSTGEIADELNVSRETATWLLTRAKKLEKAPAPKDIHIDWSSIGSSSSRLRYIASAMADM-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 123 etLEETNAEVDVVVGVAASGIPLASMMANELGADFALYHSRKGQDVVQPGQKGTISRNFGGVAGKNCVIVDDVITTGSTT 202
Cdd:PRK02277  79 --LEKEDEEVDVVVGIAKSGVPLATLVADELGKDLAIYHPKKWDHGEGEKKTGSFSRNFASVEGKRCVIVDDVITSGTTM 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 805399995 203 MEVIEQLREMGAKPRAVAVLVDKKGADMIANVPIRSLVRIVRLD 246
Cdd:PRK02277 157 KETIEYLKEHGGKPVAVVVLIDKSGIDEIDGVPVYSLIRVVRVD 200
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 116-242 8.93e-26

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 99.84  E-value: 8.93e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 116 ALCDMVLETLEETNAEVDVVVGVAASGIPLASMMANELGADFAlYHSRKGQDvvqPGQKGTISRNFggVAGKNCVIVDDV 195
Cdd:COG0461   48 LLGEALAELIKELGPEFDAVAGPATGGIPLAAAVARALGLPAI-FVRKEAKD---HGTGGQIEGGL--LPGERVLVVEDV 121

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 805399995 196 ITTGSTTMEVIEQLREMGAKPRAVAVLVD--KKGADMI--ANVPIRSLVRI 242
Cdd:COG0461  122 ITTGGSVLEAVEALREAGAEVVGVAVIVDreEGAAENLeeAGVPLHSLLTL 172
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 117-240 9.44e-25

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 95.16  E-value: 9.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 117 LCDMVLETLEETNAEVDVVVGVAASGIPLASMMANELGADFALYH-SRKGQDVVQPGQKGTISRNFGGVAGKNCVIVDDV 195
Cdd:cd06223    1 AGRLLAEEIREDLLEPDVVVGILRGGLPLAAALARALGLPLAFIRkERKGPGRTPSEPYGLELPLGGDVKGKRVLLVDDV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 805399995 196 ITTGSTTMEVIEQLREMGAKPRAVAVLVDKK-GADMIANVPIRSLV 240
Cdd:cd06223   81 IATGGTLLAAIELLKEAGAKVVGVAVLLDKPeGGARELASPGDPVY 126
pyrE PRK00455
orotate phosphoribosyltransferase; Validated
 116-242 9.71e-22

orotate phosphoribosyltransferase; Validated


Pssm-ID: 234771  Cd Length: 202  Bit Score: 89.06  E-value: 9.71e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 116 ALCDMVLETLEETNAEVDVVVGVAASGIPLASMMANELGADFAlYHSRKGQDvvqPGQKGTI--SRNFGgvagKNCVIVD 193
Cdd:PRK00455  49 LLGRFLAEAIKDSGIEFDVVAGPATGGIPLAAAVARALDLPAI-FVRKEAKD---HGEGGQIegRRLFG----KRVLVVE 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 805399995 194 DVITTGSTTMEVIEQLREMGAKPRAVAVLVD--KKGADMI--ANVPIRSLVRI 242
Cdd:PRK00455 121 DVITTGGSVLEAVEAIRAAGAEVVGVAVIVDrqSAAQEVFadAGVPLISLITL 173
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 129-242 1.65e-17

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 77.04  E-value: 1.65e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 129 NAEVDVVVGVAASGIPLASMMANELGADFAL---------------YHSRKGqdvvqPGQKGTISRNFGGvAGKNCVIVD 193
Cdd:COG0503   46 DKGIDKVVGIEARGFILAAALAYALGVPFVParkpgklpgetvseeYDLEYG-----TGDTLELHKDALK-PGDRVLIVD 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 805399995 194 DVITTGSTTMEVIEQLREMGAKPRAVAVLVDK---KGADMIANVPIRSLVRI 242
Cdd:COG0503  120 DLLATGGTAKAAIKLVEEAGAEVVGIAFLIELgflGGREKLRDYPVESLLTL 171
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 123-225 3.90e-15

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 70.47  E-value: 3.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995  123 ETLEETNAEVDVVVGVAASGIPLASMMANELGADFA-LYHSRKGQDVvqpGQKGTISRNFGGVAGKNCVIVDDVITTGST 201
Cdd:pfam00156  21 QINEDYGGKPDVVVGILRGGLPFAGILARRLDVPLAfVRKVSYNPDT---SEVMKTSSALPDLKGKTVLIVDDILDTGGT 97

                          90       100
                  ....*....|....*....|....
gi 805399995  202 TMEVIEQLREMGAKPRAVAVLVDK 225
Cdd:pfam00156  98 LLKVLELLKNVGPKEVKIAVLIDK 121
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 134-240 1.59e-14

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 71.24  E-value: 1.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 134 VVVGVAASGIPLASMMANELGADFA-LYHSRKGQDVVQpgqkgtISRNFGGVAGKNCVIVDDVITTGSTTMEVIEQLREM 212
Cdd:COG0462  164 VVVSPDVGGVKRARAFAKRLGAPLAiIDKRRPGANEVE------VMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEA 237

                         90       100       110
                 ....*....|....*....|....*....|..
gi 805399995 213 GAK-PRAVA---VLVDkKGADMIANVPIRSLV 240
Cdd:COG0462  238 GAKsVYAAAthgVLSG-PAVERLENSPIDELV 268
PRK02304 PRK02304
adenine phosphoribosyltransferase; Provisional
 129-242 8.85e-14

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 235028  Cd Length: 175  Bit Score: 67.02  E-value: 8.85e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 129 NAEVDVVVGVAASGIPLASMMANELGADFALYhsRKGQ----DVVQPGQ-----KGTISRNFGGV-AGKNCVIVDDVITT 198
Cdd:PRK02304  49 DADIDKIVGIEARGFIFGAALAYKLGIGFVPV--RKPGklprETISESYeleygTDTLEIHKDAIkPGDRVLIVDDLLAT 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 805399995 199 GSTTMEVIEQLREMGAKPRAVAVLVDK---KGADMIANVPIRSLVRI 242
Cdd:PRK02304 127 GGTLEAAIKLLERLGAEVVGAAFVIELpdlGGREKLEGYPVKSLVKF 173
pyrE TIGR00336
orotate phosphoribosyltransferase; Orotate phosphoribosyltransferase (OPRTase) is involved in ...
 131-226 4.68e-10

orotate phosphoribosyltransferase; Orotate phosphoribosyltransferase (OPRTase) is involved in the biosynthesis of pyrimidine nucleotides. Alpha-D-ribosyldiphosphate 5-phosphate (PRPP) and orotate are utilized to form pyrophosphate and orotidine 5'-monophosphate (OMP) in the presence of divalent cations, preferably Mg2+. In a number of eukaryotes, this protein is fused to a domain that catalyses the reaction (EC 4.1.1.23). The combined activity of EC 2.4.2.10 and EC 4.1.1.23 is termed uridine 5'-monophosphate synthase. The conserved Lys (K) residue at position 101 of the seed alignment has been proposed as the active site for the enzyme. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 129436 [Multi-domain]  Cd Length: 173  Bit Score: 57.05  E-value: 4.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995  131 EVDVVVGVAASGIPLASM----MANELGADFALYHSRKGQDVvqpGQKGTISrnfGGVA-GKNCVIVDDVITTGSTTMEV 205
Cdd:TIGR00336  54 EFDVIAGPALGGIPIATAvsvkLAKPGGDIPLCFNRKEAKDH---GEGGNIE---GELLeGDKVVVVEDVITTGTSILEA 127

                          90       100
                  ....*....|....*....|.
gi 805399995  206 IEQLREMGAKPRAVAVLVDKK 226
Cdd:TIGR00336 128 VEIIQAAGGQVAGVIIAVDRQ 148
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 121-215 1.03e-09

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 57.67  E-value: 1.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995  121 VLETLEETNAEVDVVVGVAASGIPLASMMANELGADFALYHSRK--GQDVVQpgqkgtISRNFGGVAGKNCVIVDDVITT 198
Cdd:TIGR01251 149 LAEYLKKKILDNPVVVSPDAGGVERAKKVADALGCPLAIIDKRRisATNEVE------VMNLVGDVEGKDVVIVDDIIDT 222

                          90
                  ....*....|....*..
gi 805399995  199 GSTTMEVIEQLREMGAK 215
Cdd:TIGR01251 223 GGTIAKAAEILKSAGAK 239
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 150-215 1.62e-08

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 54.19  E-value: 1.62e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 805399995 150 ANELGADFALYHSRKGQDVVQPGQKGTISRNFGG--VAGKNCVIVDDVITTGSTTMEVIEQLREMGAK 215
Cdd:PRK06827 226 ASVLGVDLGLFYKRRDYSRVVNGRNPIVAHEFLGrdVEGKDVLIVDDMIASGGSMIDAAKELKSRGAK 293
PRK08558 PRK08558
adenine phosphoribosyltransferase; Provisional
 131-242 1.66e-08

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 181466 [Multi-domain]  Cd Length: 238  Bit Score: 53.46  E-value: 1.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 131 EVDVVVGVAASGIPLASMMANELGADFAlyHSRKGQDV-----------VQPGQKGTISRNFGGV-AGKNCVIVDDVITT 198
Cdd:PRK08558 111 RVDVVLTAATDGIPLAVAIASYFGADLV--YAKKSKETgvekfyeeyqrLASGIEVTLYLPASALkKGDRVLIVDDIIRS 188

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 805399995 199 GSTTMEVIEQLREMGAKPRAVAVLV--DKKGADMI---ANVPIRSLVRI 242
Cdd:PRK08558 189 GETQRALLDLARQAGADVVGVFFLIavGEVGIDRAreeTDAPVDALYTL 237
ComFC COG1040
DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain [General ...
 184-222 2.32e-08

DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain [General function prediction only];


Pssm-ID: 440662 [Multi-domain]  Cd Length: 196  Bit Score: 52.52  E-value: 2.32e-08
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 805399995 184 VAGKNCVIVDDVITTGSTTMEVIEQLREMGAKPRAVAVL 222
Cdd:COG1040  153 LAGKHVLLVDDVLTTGATLAEAARALKAAGAARVDVLVL 191
PurF COG0034
Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; ...
 126-215 2.70e-08

Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Glutamine phosphoribosylpyrophosphate amidotransferase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439804 [Multi-domain]  Cd Length: 464  Bit Score: 53.87  E-value: 2.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 126 EETNAEVDVVVGVAASGIPLASMMANELGADFAL------YhsrkgqdvV-----QPGQKgtiSRNFG----------GV 184
Cdd:COG0034  275 REAPVDADVVIPVPDSGRPAAIGYAEESGIPYEEgliknrY--------VgrtfiQPTQE---LRELGvrlklnpireVV 343

                         90       100       110
                 ....*....|....*....|....*....|.
gi 805399995 185 AGKNCVIVDDVITTGSTTMEVIEQLREMGAK 215
Cdd:COG0034  344 KGKRVVLVDDSIVRGTTSRRIVKMLREAGAK 374
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
117-240 3.53e-08

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 53.03  E-value: 3.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 117 LCDMVLETLEETNAevdVVVGVAASGIPLASMMANELG-ADFALYHsrKGQDVVQPGQKgTISRNFGGVAGKNCVIVDDV 195
Cdd:PRK03092 137 LADYVRDKYDLDNV---TVVSPDAGRVRVAEQWADRLGgAPLAFIH--KTRDPTVPNQV-VANRVVGDVEGRTCVLVDDM 210

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 805399995 196 ITTGSTTMEVIEQLREMGAKPRAVA----VLVDkKGADMIANVPIRSLV 240
Cdd:PRK03092 211 IDTGGTIAGAVRALKEAGAKDVIIAathgVLSG-PAAERLKNCGAREVV 258
PLN02440 PLN02440
amidophosphoribosyltransferase
 126-215 3.72e-08

amidophosphoribosyltransferase


Pssm-ID: 215241 [Multi-domain]  Cd Length: 479  Bit Score: 53.53  E-value: 3.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 126 EETNAEVDVVVGVAASGIPLASMMANELGADF--ALYHSRK-GQDVVQPGQKgtiSRNFG---------GV-AGKNCVIV 192
Cdd:PLN02440 270 TEIPVDCDVVIPVPDSGRVAALGYAAKLGVPFqqGLIRSHYvGRTFIEPSQK---IRDFSvklklnpvrSVlEGKRVVVV 346

                         90       100
                 ....*....|....*....|...
gi 805399995 193 DDVITTGSTTMEVIEQLREMGAK 215
Cdd:PLN02440 347 DDSIVRGTTSSKIVRMLREAGAK 369
PRK06031 PRK06031
phosphoribosyltransferase; Provisional
 121-221 1.03e-07

phosphoribosyltransferase; Provisional


Pssm-ID: 235678  Cd Length: 233  Bit Score: 51.29  E-value: 1.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 121 VLETLEETNAE------VDVVVGVAASGIPLASMMANELGAD--FALYHSRKG----------QDVVQPGQKGTI---SR 179
Cdd:PRK06031  68 VLDALAEHLAEkarafdPDVVAGLPTLGLTLAAAVARKLGHTryVPLGTSRKFwyrdelsvplSSITTPDQGKRLyidPR 147

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 805399995 180 NFGGVAGKNCVIVDDVITTGSTTMEVIEQLREMGAKPRAVAV 221
Cdd:PRK06031 148 MLPLLEGRRVALIDDVISSGASIVAGLRLLAACGIEPAGIGA 189
PRK07322 PRK07322
adenine phosphoribosyltransferase; Provisional
 130-221 9.84e-07

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 180928  Cd Length: 178  Bit Score: 47.66  E-value: 9.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 130 AEVDVVVGVAASGIPLASMMANELGADF-ALYHSRKG--QD-VVQPGQKGTIS---------RNFGGVAGKNCVIVDDVI 196
Cdd:PRK07322  51 TEVDVLVTPETKGIPLAHALSRRLGKPYvVARKSRKPymQDpIIQEVVSITTGkpqllvldgADAEKLKGKRVAIVDDVV 130

                         90       100
                 ....*....|....*....|....*.
gi 805399995 197 TTGStTMEVIEQL-REMGAKPRAVAV 221
Cdd:PRK07322 131 STGG-TLTALERLvERAGGQVVAKAA 155
PRK05205 PRK05205
bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;
127-224 1.83e-06

bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;


Pssm-ID: 235365  Cd Length: 176  Bit Score: 46.66  E-value: 1.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 127 ETNAEVD--VVVGVAASGIPLASMMANELGA-----------DFALY----HSRKGQDVVQPgqkgtiSRNFGGVAGKNC 189
Cdd:PRK05205  25 ERNKGLDnlVLVGIKTRGVWLAERLAERLEQlegvdvpvgelDITLYrddlTKKGLHPQVKP------TDIPFDIEGKRV 98

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 805399995 190 VIVDDVITTGSTTMEVIEQLREMGaKPRAV--AVLVD 224
Cdd:PRK05205  99 ILVDDVLYTGRTIRAALDALFDYG-RPARVqlAVLVD 134
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 184-215 1.67e-05

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 44.90  E-value: 1.67e-05
                         10        20        30
                 ....*....|....*....|....*....|..
gi 805399995 184 VAGKNCVIVDDVITTGSTTMEVIEQLREMGAK 215
Cdd:PRK00934 202 VKGKDVLIVDDIISTGGTMATAIKILKEQGAK 233
PRK05793 PRK05793
amidophosphoribosyltransferase; Provisional
 126-215 2.05e-05

amidophosphoribosyltransferase; Provisional


Pssm-ID: 235611 [Multi-domain]  Cd Length: 469  Bit Score: 45.02  E-value: 2.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 126 EETNAEVDVVVGVAASGIPLASMMANELGADFA--LYHSRK-GQDVVQPGQK----------GTISRNfggVAGKNCVIV 192
Cdd:PRK05793 283 KEYPVDADIVIGVPDSGIPAAIGYAEASGIPYGigFIKNKYvGRTFIAPSQElreravrvklNPLKVN---VEGKRVVLI 359

                         90       100
                 ....*....|....*....|...
gi 805399995 193 DDVITTGSTTMEVIEQLREMGAK 215
Cdd:PRK05793 360 DDSIVRGTTSKRLVELLRKAGAK 382
PLN02238 PLN02238
hypoxanthine phosphoribosyltransferase
 184-226 3.83e-05

hypoxanthine phosphoribosyltransferase


Pssm-ID: 215132  Cd Length: 189  Bit Score: 43.10  E-value: 3.83e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 805399995 184 VAGKNCVIVDDVITTGSTTMEVIEQLREMGAKPRAVAVLVDKK 226
Cdd:PLN02238  95 VKGKHVLLVEDIVDTGNTLSALVAHLEAKGAASVSVCALLDKR 137
PTZ00149 PTZ00149
hypoxanthine phosphoribosyltransferase; Provisional
 172-226 4.17e-05

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 240293  Cd Length: 241  Bit Score: 43.60  E-value: 4.17e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 805399995 172 GQKGTISRNFGGVAGKNCVIVDDVITTGSTTMEVIEQLREMGAKPRAVAVLVDKK 226
Cdd:PTZ00149 136 GKLEIVSDDLSCLKDKHVLIVEDIIDTGNTLVKFCEYLKKFEPKTIRIATLFEKR 190
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 134-215 5.94e-05

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 43.37  E-value: 5.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 134 VVVGVAASGIPLASMMANELGADFALYHSRKgqdvvqPGQKGTISRN-FGGVAGKNCVIVDDVITTGSTTMEVIEQLREM 212
Cdd:PRK00553 171 VVVSPDYGGVKRARLIAESLELPLAIIDKRR------PKHNVAESINvLGEVKNKNCLIVDDMIDTGGTVIAAAKLLKKQ 244


                 ...
gi 805399995 213 GAK 215
Cdd:PRK00553 245 KAK 247
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
134-223 1.12e-04

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 42.62  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 134 VVVGVAASGIPLASMMANELGADFALYHS-RKG-QDVvqpgqkgTIS-RNFGGVAGKNCVIVDDVITTGSTTMEVIEQLR 210
Cdd:PRK07199 163 LLIGPDEESEQWVAAVAERAGAPHAVLRKtRHGdRDV-------EISlPDAAPWAGRTPVLVDDIVSTGRTLIEAARQLR 235

                         90
                 ....*....|...
gi 805399995 211 EMGAkPRAVAVLV 223
Cdd:PRK07199 236 AAGA-ASPDCVVV 247
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
134-214 1.12e-04

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 42.47  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 134 VVVGVAASGIPLASMMANELGADFALYHSRKGQDVVQPGQKGTIsrnFGGVAGKNCVIVDDVITTGSTTMEVIEQLREMG 213
Cdd:PRK02269 168 VVVSPDHGGVTRARKLAQFLKTPIAIIDKRRSVDKMNTSEVMNI---IGNVKGKKCILIDDMIDTAGTICHAADALAEAG 244


                 .
gi 805399995 214 A 214
Cdd:PRK02269 245 A 245
COG1926 COG1926
Predicted phosphoribosyltransferase [General function prediction only];
123-221 2.72e-04

Predicted phosphoribosyltransferase [General function prediction only];


Pssm-ID: 441529  Cd Length: 209  Bit Score: 40.83  E-value: 2.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 123 ETLEETNAEVDVVVGVAASGIPLASMMANELGADFALYHSRKgqdVVQPGQK----------GTISRN------------ 180
Cdd:COG1926   14 ERLAAYRGEDPVVLALPRGGVPVAAEVARALGAPLDVLVVRK---IGAPGNPelaigavaedGVVVLNedlirrlgisee 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 805399995 181 -------------------FGG------VAGKNCVIVDDVITTGSTTMEVIEQLREMGAKPRAVAV 221
Cdd:COG1926   91 yieaekarereelerrrrrYRGgrpppdLKGRTVILVDDGIATGATMRAALRALRRQGPARIVVAV 156
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
182-215 2.99e-04

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 41.26  E-value: 2.99e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 805399995 182 GGVAGKNCVIVDDVITTGSTTMEVIEQLREMGAK 215
Cdd:PRK01259 204 GDVEGRDCILVDDMIDTAGTLCKAAEALKERGAK 237
PRK09162 PRK09162
hypoxanthine-guanine phosphoribosyltransferase; Provisional
 184-226 4.64e-04

hypoxanthine-guanine phosphoribosyltransferase; Provisional


Pssm-ID: 181675  Cd Length: 181  Bit Score: 39.85  E-value: 4.64e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 805399995 184 VAGKNCVIVDDVITTGSTTMEVIEQLREMGAKPRAVAVLVDKK 226
Cdd:PRK09162  95 LKGRTVLVVDDILDEGHTLAAIRDRCLEMGAAEVYSAVLVDKT 137
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 134-240 7.17e-04

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 40.11  E-value: 7.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 134 VVVGVAASGIPLASMMANELGADFALYHSrkGQDVVQPgQKGTIsrnFGGVAGKNCVIVDDVITTGSTTMEVIEQLREMG 213
Cdd:PRK02458 172 VVVSPKNSGIKRARSLAEYLDAPIAIIDY--AQDDSER-EEGYI---IGDVAGKKAILIDDILNTGKTFAEAAKIVEREG 245

                         90       100       110
                 ....*....|....*....|....*....|
gi 805399995 214 AKP-RAVAV--LVDKKGADMIANVPIRSLV 240
Cdd:PRK02458 246 ATEiYAVAShgLFAGGAAEVLENAPIKEIL 275
PRK11595 PRK11595
DNA utilization protein GntX; Provisional
 182-214 1.55e-03

DNA utilization protein GntX; Provisional


Pssm-ID: 183221 [Multi-domain]  Cd Length: 227  Bit Score: 38.87  E-value: 1.55e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 805399995 182 GGVAGKNCVIVDDVITTGSTTMEVIEQLREMGA 214
Cdd:PRK11595 183 LPVQGQHMAIVDDVVTTGSTVAEIAQLLLRNGA 215
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 182-240 1.75e-03

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 39.09  E-value: 1.75e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 805399995 182 GGVAGKNCVIVDDVITTGSTTMEVIEQLREMGAKpRAVAV----LVDKKGADMIANVPIRSLV 240
Cdd:PTZ00145 331 GNVYDSDVIIVDDMIDTSGTLCEAAKQLKKHGAR-RVFAFathgLFSGPAIERIEASPLEEVV 392
comF TIGR00201
comF family protein; This protein is found in species that do (Bacillus subtilis, Haemophilus ...
 184-214 1.81e-03

comF family protein; This protein is found in species that do (Bacillus subtilis, Haemophilus influenzae) or do not (E. coli, Borrelia burgdorferi) have described systems for natural transformation with exogenous DNA. It is involved in competence for transformation in Bacillus subtilis. [Cellular processes, DNA transformation]


Pssm-ID: 272958 [Multi-domain]  Cd Length: 190  Bit Score: 38.27  E-value: 1.81e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 805399995  184 VAGKNCVIVDDVITTGSTTMEVIEQLREMGA 214
Cdd:TIGR00201 150 FQGRNIVLVDDVVTTGATLHEIARLLLELGA 180
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 121-215 1.81e-03

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 38.95  E-value: 1.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 121 VLETLEETNAEVDVVVGVAASGIPLASMMANEL-GADFALYHSRK-GQDVVQpgqkgtiSRN-FGGVAGKNCVIVDDVIT 197
Cdd:PRK02812 169 LLDYLASKNLEDIVVVSPDVGGVARARAFAKKLnDAPLAIIDKRRqAHNVAE-------VLNvIGDVKGKTAILVDDMID 241

                         90
                 ....*....|....*...
gi 805399995 198 TGSTTMEVIEQLREMGAK 215
Cdd:PRK02812 242 TGGTICEGARLLRKEGAK 259
PRK13809 PRK13809
orotate phosphoribosyltransferase; Provisional
 133-226 1.87e-03

orotate phosphoribosyltransferase; Provisional


Pssm-ID: 184340  Cd Length: 206  Bit Score: 38.28  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 133 DVVVGVAASGIPLASMMAneLGADFALYHSRKgqDVVQPGQKGTISRNFGGVAGKNCVIVDDVITTGSTTMEVIEQLREM 212
Cdd:PRK13809  69 SLLCGVPYTALTLATSIS--LKYNIPMVLRRK--ELKNVDPSDAIKVEGLFTPGQTCLVINDMVSSGKSIIETAVALEEE 144

                         90
                 ....*....|....
gi 805399995 213 GAKPRAVAVLVDKK 226
Cdd:PRK13809 145 GLVVREALVFLDRQ 158
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 134-215 2.15e-03

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 38.52  E-value: 2.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 134 VVVGVAASGIPLASMMANELG-ADFALY-HSRKGQDVVQPGQKgtisrnFGGVAGKNCVIVDDVITTGSTTMEVIEQLRE 211
Cdd:PLN02369 154 VVVSPDVGGVARARAFAKKLSdAPLAIVdKRRQGHNVAEVMNL------IGDVKGKVAIMVDDMIDTAGTITKGAALLHQ 227


                 ....
gi 805399995 212 MGAK 215
Cdd:PLN02369 228 EGAR 231
PLN02293 PLN02293
adenine phosphoribosyltransferase
 132-240 2.26e-03

adenine phosphoribosyltransferase


Pssm-ID: 177930  Cd Length: 187  Bit Score: 37.73  E-value: 2.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 132 VDVVVGVAASGIPLASMMANELGADFALYhsRKGQDVvqPGQK---------GT--ISRNFGGV-AGKNCVIVDDVITTG 199
Cdd:PLN02293  63 ISVVAGIEARGFIFGPPIALAIGAKFVPL--RKPGKL--PGEViseeyvleyGTdcLEMHVGAVePGERALVIDDLIATG 138

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 805399995 200 STTMEVIEQLREMGAKP---RAVAVLVDKKGADMIANVPIRSLV 240
Cdd:PLN02293 139 GTLCAAINLLERAGAEVvecACVIELPELKGREKLNGKPLFVLV 182
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
134-214 3.37e-03

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 37.99  E-value: 3.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 134 VVVGVAASGIPLASMMANELG-ADFALYHSRKGQdvvqpGQKGTISRNFGGVAGKNCVIVDDVITTGSTTMEVIEQLREM 212
Cdd:PRK04923 169 IVVSPDVGGVVRARAVAKRLDdADLAIIDKRRPR-----ANVATVMNIIGDVQGKTCVLVDDLVDTAGTLCAAAAALKQR 243


                 ..
gi 805399995 213 GA 214
Cdd:PRK04923 244 GA 245
PRTase_2 pfam15609
Phosphoribosyl transferase; This PRTase family, and C-terminal TRSP domain, are related to ...
 190-241 3.72e-03

Phosphoribosyl transferase; This PRTase family, and C-terminal TRSP domain, are related to OPRTases, and are predicted to use Orotate as substrate. These genes are found in the biosynthetic operon associated with the Ter stress-response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.


Pssm-ID: 434809  Cd Length: 189  Bit Score: 37.15  E-value: 3.72e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 805399995  190 VIVDDVITTGSTTMEVIEQLREMGAKPR-AVAVLVDKKGADMIA---------NVPIR--SLVR 241
Cdd:pfam15609 124 VLVDDEISTGNTALNLIRALHAKLPRKRyVVVSLVDWRSPEDRAafaalaaelGIPIDvvSLLE 187
PRK09219 PRK09219
xanthine phosphoribosyltransferase; Validated
 129-246 7.91e-03

xanthine phosphoribosyltransferase; Validated


Pssm-ID: 181705  Cd Length: 189  Bit Score: 36.30  E-value: 7.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805399995 129 NAEVDVVVGVAASGIPLASMMANELGAD--FA-----------LY----HSR-KGQDVvqpgqKGTISRNFGGvAGKNCV 190
Cdd:PRK09219  48 DEGITKILTIEASGIAPAVMAALALGVPvvFAkkkksltltddVYtatvYSFtKQVTS-----TVSVSKKFLS-EGDRVL 121

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 805399995 191 IVDDVITTGSTTMEVIEQLREMGAKPRAVAVLVDK---KGADMIAN--VPIRSLVRIVRLD 246
Cdd:PRK09219 122 IIDDFLANGQAALGLIDIIEQAGAKVAGIGIVIEKsfqDGRKLLEEkgYRVESLARIASLE 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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