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Conserved domains on  [gi|829574783|gb|AKL73077|]
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Methyltransferase domain [Actinobacteria bacterium IMCC26256]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11467871)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0032259|GO:0008757|GO:0008168|GO:1904047
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
49-150 5.73e-15

Trans-aconitate methyltransferase [Energy production and conversion];


:

Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 68.31  E-value: 5.73e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783  49 PGNAILEIGAGDGTVSGALLNAIPNAILLGIDIDGDPGAMFKGPTSQATFRIQSAEDLlvALGPAFDLVVISDVLHHVpt 128
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLPNVRFVVADLRDL--DPPEPFDLVVSNAALHWL-- 76

                         90       100
                 ....*....|....*....|..
gi 829574783 129 PERVALLKTASALVREGGLLAI 150
Cdd:COG4106   77 PDHAALLARLAAALAPGGVLAV 98
 
Name Accession Description Interval E-value
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
49-150 5.73e-15

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 68.31  E-value: 5.73e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783  49 PGNAILEIGAGDGTVSGALLNAIPNAILLGIDIDGDPGAMFKGPTSQATFRIQSAEDLlvALGPAFDLVVISDVLHHVpt 128
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLPNVRFVVADLRDL--DPPEPFDLVVSNAALHWL-- 76

                         90       100
                 ....*....|....*....|..
gi 829574783 129 PERVALLKTASALVREGGLLAI 150
Cdd:COG4106   77 PDHAALLARLAAALAPGGVLAV 98
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 54-148 2.27e-14

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 66.62  E-value: 2.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783   54 LEIGAGDGTVSGALLNAIPNAILLGIDIDgdPGAMFKGPTSQATFRIQSA-------EDLLVALGPAFDLVVISDVLHHV 126
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDIS--PAALEAARERLAALGLLNAvrvelfqLDLGELDPGSFDVVVASNVLHHL 78

                          90       100
                  ....*....|....*....|..
gi 829574783  127 PTPERValLKTASALVREGGLL 148
Cdd:pfam08242  79 ADPRAV--LRNIRRLLKPGGVL 98
PRK06202 PRK06202
hypothetical protein; Provisional
 7-202 6.49e-08

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 51.54  E-value: 6.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783   7 NPLTLGkkVRRFMGPLEKPAIRAYRSMfvdtnsladsiaasspgnAILEIGAGDGTVSGALLN-AIPNAILLGID-IDGD 84
Cdd:PRK06202  38 NRIVAG--WRGLYRRLLRPALSADRPL------------------TLLDIGCGGGDLAIDLARwARRDGLRLEVTaIDPD 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783  85 PGAMF----KGPTSQATFRiQSAEDLLVALGPAFDLVVISDVLHHVPTPERVALLKTASALVREgglLAIKETCRRRSFR 160
Cdd:PRK06202  98 PRAVAfaraNPRRPGVTFR-QAVSDELVAEGERFDVVTSNHFLHHLDDAEVVRLLADSAALARR---LVLHNDLIRSRLA 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 829574783 161 YLLSVFSDRYISgdRSvSFMSEDELTElINASVDGFEFRARA 202
Cdd:PRK06202 174 YALFWAGTRLLS--RS-SFVHTDGLLS-VRRSYTPAELAALA 211
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 53-151 1.31e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 48.58  E-value: 1.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783  53 ILEIGAGDGTVSgALLNAIPNAILLGIDIDGD-----PGAMFKGPTSQATFRIQSAEDLLVALGPAFDLVVISDVLHHVP 127
Cdd:cd02440    2 VLDLGCGTGALA-LALASGPGARVTGVDISPValelaRKAAAALLADNVEVLKGDAEELPPEADESFDVIISDPPLHHLV 80

                         90       100
                 ....*....|....*....|....
gi 829574783 128 tPERVALLKTASALVREGGLLAIK 151
Cdd:cd02440   81 -EDLARFLEEARRLLKPGGVLVLT 103
 
Name Accession Description Interval E-value
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
49-150 5.73e-15

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 68.31  E-value: 5.73e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783  49 PGNAILEIGAGDGTVSGALLNAIPNAILLGIDIDGDPGAMFKGPTSQATFRIQSAEDLlvALGPAFDLVVISDVLHHVpt 128
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLPNVRFVVADLRDL--DPPEPFDLVVSNAALHWL-- 76

                         90       100
                 ....*....|....*....|..
gi 829574783 129 PERVALLKTASALVREGGLLAI 150
Cdd:COG4106   77 PDHAALLARLAAALAPGGVLAV 98
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 54-148 2.27e-14

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 66.62  E-value: 2.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783   54 LEIGAGDGTVSGALLNAIPNAILLGIDIDgdPGAMFKGPTSQATFRIQSA-------EDLLVALGPAFDLVVISDVLHHV 126
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDIS--PAALEAARERLAALGLLNAvrvelfqLDLGELDPGSFDVVVASNVLHHL 78

                          90       100
                  ....*....|....*....|..
gi 829574783  127 PTPERValLKTASALVREGGLL 148
Cdd:pfam08242  79 ADPRAV--LRNIRRLLKPGGVL 98
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 49-150 2.32e-14

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 67.35  E-value: 2.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783  49 PGNAILEIGAGDGTVSGALLNAipNAILLGIDIDGDP--GAMFKGPTSQATFRIQSAEDLLVALGPaFDLVVISDVLHHV 126
Cdd:COG2227   24 AGGRVLDVGCGTGRLALALARR--GADVTGVDISPEAleIARERAAELNVDFVQGDLEDLPLEDGS-FDLVICSEVLEHL 100

                         90       100
                 ....*....|....*....|....
gi 829574783 127 PTPErvALLKTASALVREGGLLAI 150
Cdd:COG2227  101 PDPA--ALLRELARLLKPGGLLLL 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 53-146 5.83e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 65.28  E-value: 5.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783   53 ILEIGAGDGTVSGALLNAIpNAILLGIDIDGdpgAM-------FKGPTSQATFRIQSAEDLLVALGPaFDLVVISDVLHH 125
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG-GARVTGVDLSP---EMlerarerAAEAGLNVEFVQGDAEDLPFPDGS-FDLVVSSGVLHH 75

                          90       100
                  ....*....|....*....|.
gi 829574783  126 VPTPERVALLKTASALVREGG 146
Cdd:pfam13649  76 LPDPDLEAALREIARVLKPGG 96
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 45-161 6.52e-11

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 58.47  E-value: 6.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783  45 AASSPGNAILEIGAGDGTVSGALLNAipNAILLGIDIDGDP----GAMFKGPTSQATFRIQSAEDLLVALGpAFDLVVIS 120
Cdd:COG2226   18 LGLRPGARVLDLGCGTGRLALALAER--GARVTGVDISPEMlelaRERAAEAGLNVEFVVGDAEDLPFPDG-SFDLVISS 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 829574783 121 DVLHHVPTPERValLKTASALVREGGLLAIKETCRRRSFRY 161
Cdd:COG2226   95 FVLHHLPDPERA--LAEIARVLKPGGRLVVVDFSPPDLAEL 133
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 53-218 1.82e-10

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 58.39  E-value: 1.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783  53 ILEIGAGDGTVSGALLNAIpNAILLGIDIDgdPGA------MFKG-PTSQATFRIQSAEDLLVALGPAFDLVVISDVLHH 125
Cdd:COG0500   30 VLDLGCGTGRNLLALAARF-GGRVIGIDLS--PEAialaraRAAKaGLGNVEFLVADLAELDPLPAESFDLVVAFGVLHH 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783 126 VPTPERVALLKTASALVREGGLLAIKetcrrrSFRYLLSVFSDRYISGDRSVSFMSEDELTELINASVDGFEFRARAYIP 205
Cdd:COG0500  107 LPPEEREALLRELARALKPGGVLLLS------ASDAAAALSLARLLLLATASLLELLLLLRLLALELYLRALLAAAATED 180

                        170
                 ....*....|...
gi 829574783 206 PSKINVLRMLERQ 218
Cdd:COG0500  181 LRSDALLESANAL 193
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 48-197 1.44e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 55.13  E-value: 1.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783   48 SPGNAILEIGAGDGTVSgALLNAIpnaillGIDIDG-DPGAMFKGPTSQATFRIQSAEDLLVALGPAFDLVVISDVLHHV 126
Cdd:pfam13489  21 PSPGRVLDFGCGTGIFL-RLLRAQ------GFSVTGvDPSPIAIERALLNVRFDQFDEQEAAVPAGKFDVIVAREVLEHV 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 829574783  127 PTPERvaLLKTASALVREGGLLAIKETCRRRSF-RYLLSVFSDRYIsgDRSVSFMSEDELTELINASvdGFE 197
Cdd:pfam13489  94 PDPPA--LLRQIAALLKPGGLLLLSTPLASDEAdRLLLEWPYLRPR--NGHISLFSARSLKRLLEEA--GFE 159
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 54-150 3.67e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 52.28  E-value: 3.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783   54 LEIGAGDGTVSGALLNAIPNAIllGIDIDGD--PGAMFKGPTSQATFRIQSAEDLLVALGpAFDLVVISDVLHHVPTPER 131
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVT--GVDISPEmlELAREKAPREGLTFVVGDAEDLPFPDN-SFDLVLSSEVLHHVEDPER 77

                          90
                  ....*....|....*....
gi 829574783  132 ValLKTASALVREGGLLAI 150
Cdd:pfam08241  78 A--LREIARVLKPGGILII 94
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
45-150 7.79e-09

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 53.46  E-value: 7.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783  45 AASSPGNAILEIGAGDGTVSGALLNAIPNaiLLGIDIDGDPGAMFKGPTSQATFRIQSAEDLlVALGPAFDLVVISDVLH 124
Cdd:COG4976   42 LPPGPFGRVLDLGCGTGLLGEALRPRGYR--LTGVDLSEEMLAKAREKGVYDRLLVADLADL-AEPDGRFDLIVAADVLT 118

                         90       100
                 ....*....|....*....|....*.
gi 829574783 125 HVPTPERValLKTASALVREGGLLAI 150
Cdd:COG4976  119 YLGDLAAV--FAGVARALKPGGLFIF 142
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 48-150 3.03e-08

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 51.47  E-value: 3.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783  48 SPGNAILEIGAGDGTVSGALLNAIpNAILLGIDIDGDPGAMFK------GPTSQATFRIQSAEDLlvALGPAFDLVVISD 121
Cdd:COG2230   50 KPGMRVLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYAReraaeaGLADRVEVRLADYRDL--PADGQFDAIVSIG 126

                         90       100
                 ....*....|....*....|....*....
gi 829574783 122 VLHHVPTPERVALLKTASALVREGGLLAI 150
Cdd:COG2230  127 MFEHVGPENYPAYFAKVARLLKPGGRLLL 155
PRK06202 PRK06202
hypothetical protein; Provisional
 7-202 6.49e-08

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 51.54  E-value: 6.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783   7 NPLTLGkkVRRFMGPLEKPAIRAYRSMfvdtnsladsiaasspgnAILEIGAGDGTVSGALLN-AIPNAILLGID-IDGD 84
Cdd:PRK06202  38 NRIVAG--WRGLYRRLLRPALSADRPL------------------TLLDIGCGGGDLAIDLARwARRDGLRLEVTaIDPD 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783  85 PGAMF----KGPTSQATFRiQSAEDLLVALGPAFDLVVISDVLHHVPTPERVALLKTASALVREgglLAIKETCRRRSFR 160
Cdd:PRK06202  98 PRAVAfaraNPRRPGVTFR-QAVSDELVAEGERFDVVTSNHFLHHLDDAEVVRLLADSAALARR---LVLHNDLIRSRLA 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 829574783 161 YLLSVFSDRYISgdRSvSFMSEDELTElINASVDGFEFRARA 202
Cdd:PRK06202 174 YALFWAGTRLLS--RS-SFVHTDGLLS-VRRSYTPAELAALA 211
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 53-151 1.31e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 48.58  E-value: 1.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783  53 ILEIGAGDGTVSgALLNAIPNAILLGIDIDGD-----PGAMFKGPTSQATFRIQSAEDLLVALGPAFDLVVISDVLHHVP 127
Cdd:cd02440    2 VLDLGCGTGALA-LALASGPGARVTGVDISPValelaRKAAAALLADNVEVLKGDAEELPPEADESFDVIISDPPLHHLV 80

                         90       100
                 ....*....|....*....|....
gi 829574783 128 tPERVALLKTASALVREGGLLAIK 151
Cdd:cd02440   81 -EDLARFLEEARRLLKPGGVLVLT 103
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 48-164 1.52e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 43.56  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783   48 SPGNAILEIGAGDGTVSGAL-LNAIPNAILLGIDIDGDpgaMFKGPTSQA--------TFRIQSAEDLLVALGPA-FDLV 117
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELaEELGPNAEVVGIDISEE---AIEKARENAqklgfdnvEFEQGDIEELPELLEDDkFDVV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 829574783  118 VISDVLHHVPTPERValLKTASALVREGGLLAIKETCRRRSFRYLLS 164
Cdd:pfam13847  79 ISNCVLNHIPDPDKV--LQEILRVLKPGGRLIISDPDSLAELPAHVK 123
PRK08317 PRK08317
hypothetical protein; Provisional
 25-153 3.62e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 40.69  E-value: 3.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783  25 PAIRAYRSMfvdtnslADSIAASSPGNAILEIGAGDGTVSGALLNAI-PNAILLGIDIDGDPGAMFK----GPTSQATFR 99
Cdd:PRK08317   2 PDFRRYRAR-------TFELLAVQPGDRVLDVGCGPGNDARELARRVgPEGRVVGIDRSEAMLALAKeraaGLGPNVEFV 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 829574783 100 IQSAEDLLVALGpAFDLVVISDVLHHVPTPERValLKTASALVREGGLLAIKET 153
Cdd:PRK08317  75 RGDADGLPFPDG-SFDAVRSDRVLQHLEDPARA--LAEIARVLRPGGRVVVLDT 125
COG3963 COG3963
Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];
39-146 1.34e-03

Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];


Pssm-ID: 443163  Cd Length: 193  Bit Score: 38.65  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829574783  39 SLADSIAASSPGNA---ILEIGAGDGTVSGALLNA-IPNAILLGIDIDGDPGAMFKGPTSQATFRIQSAEDLLVALGPA- 113
Cdd:COG3963   32 ALARAMASEVDWSGagpVVELGPGTGVFTRAILARgVPDARLLAVEINPEFAEHLRRRFPRVTVVNGDAEDLAELLAEHg 111

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 829574783 114 ---FDLVVISDVLHHVPTPERVALLKTASALVREGG 146
Cdd:COG3963  112 igkVDAVVSGLPLLSFPPELRRAILDAAFRVLAPGG 147
Methyltransf_33 pfam10017
Histidine-specific methyltransferase, SAM-dependent; The mycobacterial members of this family ...
 41-84 3.03e-03

Histidine-specific methyltransferase, SAM-dependent; The mycobacterial members of this family are expressed from part of the ergothioneine biosynthetic gene cluster. EGTD is the histidine methyltransferase that transfers three methyl groups to the alpha-amino moiety of histidine, in the first stage of the production of this histidine betaine derivative that carries a thiol group attached to the C2 atom of an imidazole ring.


Pssm-ID: 462944  Cd Length: 304  Bit Score: 38.22  E-value: 3.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 829574783   41 ADSIAASSPGNAILEIGAGDGTVSGALLNAIPNAIL----LGIDIDGD 84
Cdd:pfam10017  53 AAEIAALIPAAVLVELGSGSSRKTRLLLDALPAAGKpvtyVPIDISAE 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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