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Conserved domains on  [gi|937519124|gb|ALI39610|]
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transcriptional regulator [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
11-97 3.89e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 87.25  E-value: 3.89e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937519124 11 AEQAAALLKAMSHPKRLLILCMLSGSPgTSAGELTRITGLSASATSQHLARMRDEGLIDSQRDAQRILYSIKNEAVNAII 90
Cdd:COG0640   7 LEELAELFKALADPTRLRILRLLAEGE-LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELL 85


                ....*..
gi 937519124 91 ATLKNVY 97
Cdd:COG0640  86 EWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
11-97 3.89e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 87.25  E-value: 3.89e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937519124 11 AEQAAALLKAMSHPKRLLILCMLSGSPgTSAGELTRITGLSASATSQHLARMRDEGLIDSQRDAQRILYSIKNEAVNAII 90
Cdd:COG0640   7 LEELAELFKALADPTRLRILRLLAEGE-LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELL 85


                ....*..
gi 937519124 91 ATLKNVY 97
Cdd:COG0640  86 EWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 14-90 2.04e-22

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 82.51  E-value: 2.04e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 937519124 14 AAALLKAMSHPKRLLILCMLSGSPgTSAGELTRITGLSASATSQHLARMRDEGLIDSQRDAQRILYSIKNEAVNAII 90
Cdd:NF033788  1 LAELFKALADPTRLRILELLAEGE-LCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-95 1.31e-15

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 65.40  E-value: 1.31e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 937519124 18 LKAMSHPKRLLILCMLSGSPgTSAGELTRITGLSASATSQHLARMRDEGLIDSQRDAQRILYSIK-NEAVNAIIATLKN 95
Cdd:cd00090   1 LKALSDPTRLRILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTdAERLLALLESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
29-93 2.76e-15

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 64.15  E-value: 2.76e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 937519124   29 ILCMLSGSPGTsAGELTRITGLSASATSQHLARMRDEGLIDSQRDAQRILYSIKNEAVNAIIATL 93
Cdd:smart00418  2 ILKLLAEGELC-VCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 23-68 2.12e-10

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 51.29  E-value: 2.12e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 937519124  23 HPKRLLILCMLSGSPgTSAGELTRITGLSASATSQHLARMRDEGLI 68
Cdd:pfam01022  1 DPTRLKILKLLAEGE-LCVCELAEELGLSQSTVSHHLKKLREAGLV 45
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 25-70 3.11e-04

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 37.72  E-value: 3.11e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 937519124   25 KRLLILCMLSGSPGTSAGELTRITGLSASATSQHLARMRDEGLIDS 70
Cdd:TIGR01884 144 EELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQ 189
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
11-97 3.89e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 87.25  E-value: 3.89e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937519124 11 AEQAAALLKAMSHPKRLLILCMLSGSPgTSAGELTRITGLSASATSQHLARMRDEGLIDSQRDAQRILYSIKNEAVNAII 90
Cdd:COG0640   7 LEELAELFKALADPTRLRILRLLAEGE-LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELL 85


                ....*..
gi 937519124 91 ATLKNVY 97
Cdd:COG0640  86 EWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 14-90 2.04e-22

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 82.51  E-value: 2.04e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 937519124 14 AAALLKAMSHPKRLLILCMLSGSPgTSAGELTRITGLSASATSQHLARMRDEGLIDSQRDAQRILYSIKNEAVNAII 90
Cdd:NF033788  1 LAELFKALADPTRLRILELLAEGE-LCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-95 1.31e-15

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 65.40  E-value: 1.31e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 937519124 18 LKAMSHPKRLLILCMLSGSPgTSAGELTRITGLSASATSQHLARMRDEGLIDSQRDAQRILYSIK-NEAVNAIIATLKN 95
Cdd:cd00090   1 LKALSDPTRLRILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTdAERLLALLESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
29-93 2.76e-15

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 64.15  E-value: 2.76e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 937519124   29 ILCMLSGSPGTsAGELTRITGLSASATSQHLARMRDEGLIDSQRDAQRILYSIKNEAVNAIIATL 93
Cdd:smart00418  2 ILKLLAEGELC-VCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
12-85 7.73e-12

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 57.58  E-value: 7.73e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 937519124  12 EQAAALLKAMSHPKRLLILCMLSGSPGTSAGELTRITGLSASATSQHLARMRDEGLIDSQRDAQRILYSIKNEA 85
Cdd:COG3398   85 EEEKKILAYLRRETPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPPE 158
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
9-90 1.99e-10

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 53.11  E-value: 1.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937519124   9 ASAEQAAALLKAMSHPKRLLILCMLSGSPGTsAGELTRITGLSASATSQHLARMRDEGLIDSQRD-----AQRILYSIKN 83
Cdd:COG1777    2 SDDEDLDRLLDALGNPTRRRILALLSEEPAY-VSELARELGVSRQAVYKHLRKLEEAGLVESYREgredgRARKYYRLSA 80


                 ....*..
gi 937519124  84 EAVNAII 90
Cdd:COG1777   81 FRLEVTL 87
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 23-68 2.12e-10

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 51.29  E-value: 2.12e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 937519124  23 HPKRLLILCMLSGSPgTSAGELTRITGLSASATSQHLARMRDEGLI 68
Cdd:pfam01022  1 DPTRLKILKLLAEGE-LCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
12-86 9.46e-09

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 48.42  E-value: 9.46e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937519124 12 EQAAALLKAMSHPKRLLILCMLSGSPgTSAGELTRITGLSASATSQHLARMRDEGLIDS-----QRDAQRILYSIKNEAV 86
Cdd:COG4189   7 EESLEVLKALASETRLRILRLLAEEP-LNVNELAEALGLPKSTVSYHIRKLEEAGLIRTeykpgKRGRQKICYLRVDKIL 85
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 15-73 6.98e-08

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 45.22  E-value: 6.98e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 937519124  15 AALLKAMSHPKRLLILCMLSGSPGTSAGELTRITGLSASATSQHLARMRDEGLIDSQRD 73
Cdd:pfam12840  1 DDVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVRE 59
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 24-74 1.76e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 41.42  E-value: 1.76e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 937519124  24 PKRLLILCMLSGSPGTSAGELTRITGLSASATSQHLARMRDEGLIDSQRDA 74
Cdd:pfam12802  5 PAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSP 55
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
19-93 8.09e-06

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 41.79  E-value: 8.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937519124  19 KAMSHPKRLLILCMLSGSPGTSAGELTRITGLSASATSQHLARMRDEGLIDSQRDA----------------QRILYSIK 82
Cdd:COG3398   16 NVLDNDTRRRIYEYIRENPGIHFREIVRDLGLNRGTLRYHLRRLEREGKITSEKDGgrtryfpnsgtyseeeKKILAYLR 95

                         90
                 ....*....|.
gi 937519124  83 NEAVNAIIATL 93
Cdd:COG3398   96 RETPRRILLYL 106
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
24-75 1.03e-05

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 41.11  E-value: 1.03e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 937519124  24 PKRLLILCMLSGSPGTSAGELTRITGLSASATSQHLARMRDEGLIDSQRDAQ 75
Cdd:COG1846   38 PAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
25-68 2.24e-05

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 38.18  E-value: 2.24e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 937519124  25 KRLLILCMLSGSPGTSAGELTRITGLSASATSQHLARMRDEGLI 68
Cdd:pfam13412  2 TDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
24-79 5.29e-05

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 38.73  E-value: 5.29e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 937519124    24 PKRLLILCMLSGSPGTSAGELTRITGLSASATSQHLARMRDEGLIDSQRDA--QRILY 79
Cdd:smart00347  10 PTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPedRRSVL 67
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 43-84 9.87e-05

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 37.59  E-value: 9.87e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 937519124 43 ELTRITGLSASATSQHLARMRDEGLIDSQRDAQRILYSIKNE 84
Cdd:COG2512  35 EIVKETGWSKSKVSRLLSRLEERGLIEKERVGRENVVELPED 76
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
20-72 2.40e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 37.98  E-value: 2.40e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 937519124  20 AMSHPKRLLILCMLSGSPGTSAGELTRITGLSASATSQHLARMRDEGLIDSQR 72
Cdd:COG2345    9 ALADPTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERET 61
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 25-70 3.11e-04

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 37.72  E-value: 3.11e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 937519124   25 KRLLILCMLSGSPGTSAGELTRITGLSASATSQHLARMRDEGLIDS 70
Cdd:TIGR01884 144 EELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQ 189
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 26-73 2.49e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 33.29  E-value: 2.49e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 937519124  26 RLLILCMLSGSPGTSAGELTRITGLSASATSQHLARMRDEGLIDSQRD 73
Cdd:pfam01047  5 QFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRS 52
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
29-68 9.20e-03

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 33.21  E-value: 9.20e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 937519124  29 ILCMLSGSPGTSAGELTRITGLSASATSQHLARMRDEGLI 68
Cdd:COG1522   10 ILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVI 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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