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Conserved domains on  [gi|974301044|gb|ALY83602|]
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MFS transporter [Pseudomonas aeruginosa]

Protein Classification

MFS transporter( domain architecture ID 13022908)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
19-424 3.12e-87

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 270.21  E-value: 3.12e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  19 RLRLLPFLVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGL 98
Cdd:cd17319    1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  99 VSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifgla 178
Cdd:cd17319   81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFG----- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 179 nWQWLFVTEGLLASLVGIAAYFYLvdrprdagwlsdeqkralegelaeedtrkqargphgflsalrsGQVLKFCLVYFTI 258
Cdd:cd17319  156 -WRWAFIIEGLLGLLLAVLWWFYL-------------------------------------------RQVWGLALGYFGI 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 259 QMSVYGVVFYLPTRIASFLdGQVGLNVGLITAIPWVCALAVTRLVTRQADR--SGQHRQLAVAMLGMAAAGIAASALAGN 336
Cdd:cd17319  192 NYALYGLLTWLPTYLKQAR-GFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllRGARRLVIIIGLLLAAVGLLLAYLTTS 270
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 337 LGLAVIAFCFAASGFVSVQPLFWTLPTGYLSGAAAASGIALINSLGNLGGFVAPNLKTLMESQFADPRAGMFALAAVGLL 416
Cdd:cd17319  271 PVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALL 350

                 ....*...
gi 974301044 417 GACLLARL 424
Cdd:cd17319  351 AALLVLLL 358
 
Name Accession Description Interval E-value
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
19-424 3.12e-87

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 270.21  E-value: 3.12e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  19 RLRLLPFLVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGL 98
Cdd:cd17319    1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  99 VSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifgla 178
Cdd:cd17319   81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFG----- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 179 nWQWLFVTEGLLASLVGIAAYFYLvdrprdagwlsdeqkralegelaeedtrkqargphgflsalrsGQVLKFCLVYFTI 258
Cdd:cd17319  156 -WRWAFIIEGLLGLLLAVLWWFYL-------------------------------------------RQVWGLALGYFGI 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 259 QMSVYGVVFYLPTRIASFLdGQVGLNVGLITAIPWVCALAVTRLVTRQADR--SGQHRQLAVAMLGMAAAGIAASALAGN 336
Cdd:cd17319  192 NYALYGLLTWLPTYLKQAR-GFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllRGARRLVIIIGLLLAAVGLLLAYLTTS 270
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 337 LGLAVIAFCFAASGFVSVQPLFWTLPTGYLSGAAAASGIALINSLGNLGGFVAPNLKTLMESQFADPRAGMFALAAVGLL 416
Cdd:cd17319  271 PVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALL 350

                 ....*...
gi 974301044 417 GACLLARL 424
Cdd:cd17319  351 AALLVLLL 358
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
28-390 9.81e-65

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 213.35  E-value: 9.81e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044   28 LMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAMMFAD 107
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  108 DAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifglanWQWLFVTE 187
Cdd:TIGR00893  81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFS------WQWAFIIE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  188 GLLASLVGIAAYFYLVDRPRDAGWLSDEQKRALEGELAEEDTRKQARGP--HGFLSALRSGQVLKFCLVYFTIQMSVYGV 265
Cdd:TIGR00893 155 GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPkkYQIKELLKDRRVWGLALGQFLVNIGLGFF 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  266 VFYLPTRIASFLdGQVGLNVGLITAIPWVCALAVTRLVTRQAD---RSGQHRQLAVAMLGMAAAGIAASALAGNLGLAVI 342
Cdd:TIGR00893 235 LTWFPTYLVQER-GLSILEAGFMASLPGIVGFIGMILGGRLSDlllRRGKSLVFARKTAIIAGLVLSLLMFATNYVNIPY 313
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 974301044  343 -AFCFAASGFVSVQ--PLFWTLPTGYLSGAAAASGIALINSLGNLGGFVAP 390
Cdd:TIGR00893 314 aALALVALGFFGLGagAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGP 364
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
19-425 1.56e-44

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 158.88  E-value: 1.56e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  19 RLRLLPFLVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGL 98
Cdd:COG2271    8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  99 VSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifgla 178
Cdd:COG2271   88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG----- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 179 nWQWLFVTEGLLASLVGIAayfylvdrprdagwlsdeqkralegelaeedtrkqargphgflsalrsgQVLKFCLVYFTI 258
Cdd:COG2271  163 -WRAAFLILGLPGLLLALL-------------------------------------------------RFWLLALAYFLV 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 259 QMSVYGVVFYLPTRIASFLdGQVGLNVGLITAIPWVCALAVTRLVTRQADRSGQHR-QLAVAMLGMAAAGIAASALAGNL 337
Cdd:COG2271  193 YFALYGFLTWLPTYLVEVR-GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRkLVLAIGLLLAALALLLLALLPSP 271
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 338 GLAVIAFCFAASGFVSVQPLFWTLPTGYLSGAAAASGIALINSLGNLGGFVAPNLKTLMeSQFADPRAGMFALAAVGLLG 417
Cdd:COG2271  272 ALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL-LDATGYQAAFLLLAALALLA 350

                 ....*...
gi 974301044 418 ACLLARLK 425
Cdd:COG2271  351 ALLALLLL 358
MFS_1 pfam07690
Major Facilitator Superfamily;
26-390 1.72e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 92.10  E-value: 1.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044   26 LVLMYVLAFIDRANVGYARA-FLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAMM 104
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  105 FADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifglanWQWLF 184
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG------WRAAF 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  185 VTEGLLASLVGIAAYFYLVDRPRDagwlsdeqkralegelAEEDTRKQARGPHGFLSALRSGQVLKFCLVYFTIQMSVYG 264
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESK----------------RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  265 VVFYLPTRIASFldGQVGLNVGLITAIPWVCALAVTRLVTRQADRSGQHRQLAVAMLGM--AAAGIAASALAGNLGLAVI 342
Cdd:pfam07690 219 LLTYLPLYQEVL--GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLilAALGLLLLSLTLSSLWLLL 296
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 974301044  343 AFCFAASGFVSVQPLFWTLPTGYLSGAAAASGIALINSLGNLGGFVAP 390
Cdd:pfam07690 297 ALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
19-424 3.12e-87

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 270.21  E-value: 3.12e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  19 RLRLLPFLVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGL 98
Cdd:cd17319    1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  99 VSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifgla 178
Cdd:cd17319   81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFG----- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 179 nWQWLFVTEGLLASLVGIAAYFYLvdrprdagwlsdeqkralegelaeedtrkqargphgflsalrsGQVLKFCLVYFTI 258
Cdd:cd17319  156 -WRWAFIIEGLLGLLLAVLWWFYL-------------------------------------------RQVWGLALGYFGI 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 259 QMSVYGVVFYLPTRIASFLdGQVGLNVGLITAIPWVCALAVTRLVTRQADR--SGQHRQLAVAMLGMAAAGIAASALAGN 336
Cdd:cd17319  192 NYALYGLLTWLPTYLKQAR-GFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllRGARRLVIIIGLLLAAVGLLLAYLTTS 270
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 337 LGLAVIAFCFAASGFVSVQPLFWTLPTGYLSGAAAASGIALINSLGNLGGFVAPNLKTLMESQFADPRAGMFALAAVGLL 416
Cdd:cd17319  271 PVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALL 350

                 ....*...
gi 974301044 417 GACLLARL 424
Cdd:cd17319  351 AALLVLLL 358
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
28-390 9.81e-65

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 213.35  E-value: 9.81e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044   28 LMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAMMFAD 107
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  108 DAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifglanWQWLFVTE 187
Cdd:TIGR00893  81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFS------WQWAFIIE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  188 GLLASLVGIAAYFYLVDRPRDAGWLSDEQKRALEGELAEEDTRKQARGP--HGFLSALRSGQVLKFCLVYFTIQMSVYGV 265
Cdd:TIGR00893 155 GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPkkYQIKELLKDRRVWGLALGQFLVNIGLGFF 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  266 VFYLPTRIASFLdGQVGLNVGLITAIPWVCALAVTRLVTRQAD---RSGQHRQLAVAMLGMAAAGIAASALAGNLGLAVI 342
Cdd:TIGR00893 235 LTWFPTYLVQER-GLSILEAGFMASLPGIVGFIGMILGGRLSDlllRRGKSLVFARKTAIIAGLVLSLLMFATNYVNIPY 313
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 974301044  343 -AFCFAASGFVSVQ--PLFWTLPTGYLSGAAAASGIALINSLGNLGGFVAP 390
Cdd:TIGR00893 314 aALALVALGFFGLGagAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGP 364
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
20-392 5.37e-53

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 182.45  E-value: 5.37e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  20 LRLLPFLVLMYVLAFIDRANVGYAR-AFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGL 98
Cdd:cd17327    4 LFILPLLCILYFLQYLDKSNISNAAvMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  99 VSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGIFGLA 178
Cdd:cd17327   84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVGGLA 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 179 NWQWLFVTEGLLASLVGIAAYFYLVDRPRDAGWLSDEQKRALEGELAEEDTRK--QARGPHGFLSALRSGQVLKFCLVYF 256
Cdd:cd17327  164 GWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKgdQKFKWKQIKEAFKDPRTWLLFLFFF 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 257 TIQMSVYGVVFYLPTRIASFldGQVGLNVGLITAIPWVCALAVTRLVTRQADRSGQHRQLAVAMLGMAAAGIAASALAGN 336
Cdd:cd17327  244 CSQITNNGISNFLPLILKSL--GFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIILLAAPN 321
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 974301044 337 LGLAVIAFCFAASGFVSVQPLFWTLPTGYLSGAAA-ASGIALINSLGNLGGFVAPNL 392
Cdd:cd17327  322 PPGAYFAAYILGGGSYAGFPILLSWISSNCAGYTKrATVLAIMLIFYNVGNIVAPQI 378
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
19-425 1.56e-44

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 158.88  E-value: 1.56e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  19 RLRLLPFLVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGL 98
Cdd:COG2271    8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  99 VSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifgla 178
Cdd:COG2271   88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG----- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 179 nWQWLFVTEGLLASLVGIAayfylvdrprdagwlsdeqkralegelaeedtrkqargphgflsalrsgQVLKFCLVYFTI 258
Cdd:COG2271  163 -WRAAFLILGLPGLLLALL-------------------------------------------------RFWLLALAYFLV 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 259 QMSVYGVVFYLPTRIASFLdGQVGLNVGLITAIPWVCALAVTRLVTRQADRSGQHR-QLAVAMLGMAAAGIAASALAGNL 337
Cdd:COG2271  193 YFALYGFLTWLPTYLVEVR-GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRkLVLAIGLLLAALALLLLALLPSP 271
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 338 GLAVIAFCFAASGFVSVQPLFWTLPTGYLSGAAAASGIALINSLGNLGGFVAPNLKTLMeSQFADPRAGMFALAAVGLLG 417
Cdd:COG2271  272 ALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL-LDATGYQAAFLLLAALALLA 350

                 ....*...
gi 974301044 418 ACLLARLK 425
Cdd:COG2271  351 ALLALLLL 358
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
17-426 1.84e-33

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 129.62  E-value: 1.84e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  17 TSRLRLLPFLVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTW 96
Cdd:COG2223    1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  97 GLVSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifg 176
Cdd:COG2223   81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG--- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 177 lanWQWLFVTEGLLASLVGIAAYFYLVDRPRDAgwlsdeqkralegelaeedTRKQARGPHGFLSALRSGQVLKFCLVYF 256
Cdd:COG2223  158 ---WRNAFLILGILLLVVAVLAWLFLRDPPAGA-------------------AAAAKASLRDQLEALRDPRFWLLSLLYF 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 257 TIQMSVYGVVFYLPTRIASFLdGQVGLNVGLITAIPWVCALAVTRLVTRQADRSGQHRQLAVAMLGMAAAGIAASALAGN 336
Cdd:COG2223  216 GTFGSFIGFSSWLPPYLVDQF-GLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGS 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 337 LGLAVIAFCFAASGFVSVQPLFWTLPTGYLSGAAAASGIALINSLGNLGGFVAPNLKTLMESQFADPRAGMFALAAVGLL 416
Cdd:COG2223  295 LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALV 374
                        410
                 ....*....|
gi 974301044 417 GACLLARLKT 426
Cdd:COG2223  375 ALVLTLLLYR 384
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
26-421 8.57e-24

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 102.12  E-value: 8.57e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  26 LVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAMMF 105
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 106 ADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifglANWQWLFV 185
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG----FGWRAVFL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 186 TEGLLASLVGIAAYFYLVDRPRDAgwlsdeqkralegeLAEEDTRKQARGPHGFLSALRSGQVLKFCLVYFTIQMSVYGV 265
Cdd:cd06174  157 IAAALALLAAILLLLVVPDPPESA--------------RAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSF 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 266 VFYLPTRIASFLdGQVGLNVGLITAIPWVCALAVTRLVTRQADRSGQHRQLAVAMLGMAAAGIAASALAGNLGLAVIAFC 345
Cdd:cd06174  223 STLLPLFLLDLG-GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLL 301
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 974301044 346 FAASGFVSVQPLFWTLPTGYLSGAAAASGIALINSLGNLGGFVAPNLKTLMESQFADPRAGMFALAAVGLLGACLL 421
Cdd:cd06174  302 LLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
13-361 8.81e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 93.11  E-value: 8.81e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  13 SAIATSRLRLLPFLVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRI 92
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  93 MVTWGLVSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFH 172
Cdd:COG2814   82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 173 GifglanWQWLFVTEGLLASLVGIAAYFYLVDRPRdagwlsdeqkralegelaeedtRKQARGPHGFLSALRSGQVLKFC 252
Cdd:COG2814  162 G------WRWVFLVNAVLALLALLLLLRLLPESRP----------------------AARARLRGSLRELLRRPRLLLLL 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 253 LVYFTIQMSVYGVVFYLPTRIASFLdGQVGLNVGLITAIPWVCALAVTRLVTRQADRSGQHRQLAVAMLgMAAAGIAASA 332
Cdd:COG2814  214 LLAFLLGFGFFALFTYLPLYLQEVL-GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLL-LLALGLLLLA 291
                        330       340
                 ....*....|....*....|....*....
gi 974301044 333 LAGNLGLAVIAFCFAASGFVSVQPLFWTL 361
Cdd:COG2814  292 LAGSLWLLLLALFLLGFGFGLLFPLLQAL 320
MFS_1 pfam07690
Major Facilitator Superfamily;
26-390 1.72e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 92.10  E-value: 1.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044   26 LVLMYVLAFIDRANVGYARA-FLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAMM 104
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  105 FADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifglanWQWLF 184
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG------WRAAF 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  185 VTEGLLASLVGIAAYFYLVDRPRDagwlsdeqkralegelAEEDTRKQARGPHGFLSALRSGQVLKFCLVYFTIQMSVYG 264
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESK----------------RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  265 VVFYLPTRIASFldGQVGLNVGLITAIPWVCALAVTRLVTRQADRSGQHRQLAVAMLGM--AAAGIAASALAGNLGLAVI 342
Cdd:pfam07690 219 LLTYLPLYQEVL--GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLilAALGLLLLSLTLSSLWLLL 296
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 974301044  343 AFCFAASGFVSVQPLFWTLPTGYLSGAAAASGIALINSLGNLGGFVAP 390
Cdd:pfam07690 297 ALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
30-390 3.58e-15

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 76.65  E-value: 3.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044   30 YVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAMMFADDA 109
Cdd:TIGR00881   4 YAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  110 MTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifglaNWQWLFVTEGL 189
Cdd:TIGR00881  84 WVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELY-----SWHWVFIVPGI 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  190 LASLVGIAAYFYLVDRPRDAGWLSDEQKRALEGELAEEDTRKQARGPHGFLS-ALRSGQVLKFCLVYFTIQMSVYGVVFY 268
Cdd:TIGR00881 159 IAIIVSLICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQyVLLNKVLWYISLGYVFVYVVRTGILDW 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  269 LPTRIASFLdGQVGLNVGLITAIPWVCALAVTRLVTRQADR--SGQHRQLAVAMLGMAAAGIAASALAGNLGLAVIAFCF 346
Cdd:TIGR00881 239 SPLYLTQEK-GFSKEKASWAFTLYELGGLVGTLLAGWLSDKlfNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICL 317
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 974301044  347 AASGFVSVQP--LFWTLPTGYLSGAAAASGIALINSLGNLGGFVAP 390
Cdd:TIGR00881 318 FALGFLVYGPqmLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAG 363
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
49-425 6.29e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 69.91  E-value: 6.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  49 ADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAMMFADDAMTFYVLRFLLGVAEAGFFP 128
Cdd:cd17325   24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 129 GIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGIfglanwQWLFVTEGLLASLVGIAAYFYLVDRPRD 208
Cdd:cd17325  104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGY------RAPFLVCAALALLALVLALLLLPEPRPP 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 209 agwlsdeqkralegelAEEDTRKQARGPHGFLSALRSGQVLKFCLVYFTIQMSVYGVVFYLPTRIASFLDGQVGLnVGLI 288
Cdd:cd17325  178 ----------------PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ-IGLL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 289 TAIPWVCALAVTRLVTRQADRSGqHRQLAVAMLGMAAAGIAASALAGNLGLAVIAFCFAASGFVSVQPLFWTLPTGYLSG 368
Cdd:cd17325  241 FGAQGLASALSQPPAGKLSDRIG-RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPP 319
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 974301044 369 AAAASGIALINSLGNLGGFVAPNLKTLMeSQFADPRAGMFALAAVGLLGACLLARLK 425
Cdd:cd17325  320 EGRGTAMGLFNTAFSLGMVLGPLLGGFL-YDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
47-361 7.61e-13

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 69.50  E-value: 7.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  47 LQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAMMFADDAMTFYVLRFLLGVAEAGF 126
Cdd:cd17324   25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 127 FPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifglanWQWLFVTEGLLASLVGIAAYFYLVDRP 206
Cdd:cd17324  105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG------WRAAFLAIAVLALLAALLLWRLLPSLP 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 207 rdagwlsdeqkralegelAEEDTRKQARGphGFLSALRSGQVLKFCLVYFTIQMSVYGVVFYLPTRIASfLDGQVGLNVG 286
Cdd:cd17324  179 ------------------PKKPGSLGLLS--SLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTD-VPGFSSSAII 237
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 974301044 287 LITAIPWVCALAVTRLVTRQADRSGqHRQLAVAMLGMAAAGIAASALAGNLGLAVIAFCFAASGFVSVQPLFWTL 361
Cdd:cd17324  238 GLLLLFGVAGVVGSPLAGRLADRGG-RRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR 311
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
11-300 1.35e-10

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 62.14  E-value: 1.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  11 LSSAIATSRLRLLPFLVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLC 90
Cdd:COG0477    4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  91 RIMVTWGLVSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLE 170
Cdd:COG0477   84 IGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 171 FHGifglanWQWLFVTEGLLASLVGIAAYFYLVDRPRDAGWLSDEQKRALEGELAEEDTRKQARGPHGFLSALRSGQVLK 250
Cdd:COG0477  164 ALG------WRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGA 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 974301044 251 FCLVYFTIQMSVYGVVFYLPTRIASFLDGQVGLNVGLITAIPWVCALAVT 300
Cdd:COG0477  238 ALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLL 287
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
23-207 2.96e-10

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 61.87  E-value: 2.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  23 LPFLVLMYVLAFIDRANV-GYARAfLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSA 101
Cdd:cd17328    1 VAVLFLINLLNYMDRFTIaGVLPD-IQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 102 AMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifglaNWQ 181
Cdd:cd17328   80 LSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG-----GWR 154
                        170       180
                 ....*....|....*....|....*.
gi 974301044 182 WLFVTEGLLASLVGIAAYFYLVDRPR 207
Cdd:cd17328  155 WAFRVTGVLGVLLAILLLLFVREPPR 180
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
26-191 5.62e-10

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 60.65  E-value: 5.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  26 LVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAM-M 104
Cdd:cd17380    4 LFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTpL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 105 FADDAMTF-YVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifglanWQWL 183
Cdd:cd17380   84 LAYSSLPLlILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYG------WPSV 157

                 ....*...
gi 974301044 184 FVTEGLLA 191
Cdd:cd17380  158 FYFFGLLG 165
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
26-422 6.40e-10

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 60.71  E-value: 6.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  26 LVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAMMF 105
Cdd:cd17475    1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 106 ADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPlalvLGGPLSGWLLEFhgIFGLANWQWLFV 185
Cdd:cd17475   81 VGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVP----LGGALAAALLPP--LALHYGWRAAFV 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 186 TEGLLASLVGIAAYFYLVDRPRdagwlsdeqkralegelAEEDTRKQARGPHGFLSALRSGQVLKFCLVYFTIQMSVYGV 265
Cdd:cd17475  155 VAGLVSILAAVLFWLFYREPPA-----------------ASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFAL 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 266 VFYLPTriasFLDGQVGLNVGLITAIPWVCAL--AVTRLVT-RQADRSGQHRQLAV--------AMLGMAAAGIAASALA 334
Cdd:cd17475  218 LTFLLL----FLHDHLGLSVVAAGALLAVAQLggALGRIGLgRVSDRVFGGRRRPVlvitaaiaAAALLVLSLLSPGTPL 293
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 335 GNLGLAVIAFCFAASGFvsvQPLFWTLPTGYLSGAAAASGIALINSLGNLGGFVAPNLKTLMESQFADPRAGMFALAAVG 414
Cdd:cd17475  294 WLLVLLLILLGLFAIGW---NGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLL 370

                 ....*...
gi 974301044 415 LLGACLLA 422
Cdd:cd17475  371 VLAALLLL 378
MFS_UhpC cd17488
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ...
19-207 3.47e-09

Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341041 [Multi-domain]  Cd Length: 364  Bit Score: 58.19  E-value: 3.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  19 RLRLLPFLVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGL 98
Cdd:cd17488    1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  99 VSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRaqalGLFYFGLPLALVLGGPLSGWLLEFHGIFGla 178
Cdd:cd17488   81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNER----GFWWSIWNTSHNIGGALIPILTGFAALTY-- 154
                        170       180
                 ....*....|....*....|....*....
gi 974301044 179 NWQWLFVTEGLLASLVGIAAYFYLVDRPR 207
Cdd:cd17488  155 GWRAGMYVPGIIAILMGIVLCWRLRDRPP 183
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
4-424 5.55e-09

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 57.58  E-value: 5.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044   4 MNDHARLLSSAIATSRLRLLPFLVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRL 83
Cdd:COG2807    1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  84 GARVWLCRIMVTWGLVSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRsRAQALGLFYFGLPLALVLGGP 163
Cdd:COG2807   81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 164 LSGWLLEFHGifglanWQWLFVTEGLLASLVGIAAYFYLVDRPRDAGwlsdeqkralegelaeedtrkQARGPHGFLSAL 243
Cdd:COG2807  160 LTVPLAAALG------WRGALAVWALLALLALLLWLPLLRRRPAAAA---------------------AAPAAASLRSLW 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 244 RSGQVLKFCLVYFTIQMSVYGVVFYLPTRIAS--FLDGQVGLNVGLITAIPWVCALAVTRLvtrqADRSGQHRQLAVAML 321
Cdd:COG2807  213 RSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDagLSAATAGLLLSLFQLAGIPGSLLVPLL----ADRLGDRRPLLLLLG 288
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 322 GMAAAGIAASALAGNLGLAVIAFCFAAsGFVSVQPLFWTLPTGYLSGAAAASGIA-LINSLGNLGGFVAPNLKTLMESQF 400
Cdd:COG2807  289 LLGLAGLLGLLLAPGSLPWLWAVLLGL-GQGGLFPLALTLIGLRARTPAEAAALSgMAQSVGYLLAALGPLLVGALHDAT 367
                        410       420
                 ....*....|....*....|....
gi 974301044 401 ADPRAGMFALAAVGLLGACLLARL 424
Cdd:COG2807  368 GSWTAALLLLAALAVLMLVAGLLA 391
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
26-184 1.62e-07

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 52.95  E-value: 1.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  26 LVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAMMF 105
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 974301044 106 ADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifglanWQWLF 184
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFG------WRWIF 153
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
30-232 5.09e-07

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 51.47  E-value: 5.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  30 YVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAMMFADDA 109
Cdd:cd17345   12 YAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSA 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 110 MT----FYVLRFLLGVAE-AGFFPGIILyLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLefhGIFGLANWQWLF 184
Cdd:cd17345   92 TSsvglMFILLFLNGWFQgMGWPPSGRT-MVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGL---AIFGDGWWRGAF 167
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 974301044 185 VTEGLLASLVGIAAYFYLVDRPRDAGWLSDEQKRALEGELAEEDTRKQ 232
Cdd:cd17345  168 IFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQ 215
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
26-271 9.51e-07

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 50.82  E-value: 9.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044   26 LVLMYVLAFIDRANV---GYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAA 102
Cdd:TIGR00895  19 IILSFLIMLMDGYDLaamGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLL 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  103 MMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifglanWQW 182
Cdd:TIGR00895  99 CALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFG------WRS 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  183 LFVTEGLLASLVGIAAYFYLvdrPRDAGWLSDEQKRALEGELAEEDTRKQARGPH-------------GFLSALRSGQVL 249
Cdd:TIGR00895 173 LFYVGGIAPLLLLLLLMRFL---PESIDFLVSKRPETVRRIVNAIAPQMQAEAQSalpeqkstqgtkrSVFKALFQGKTA 249
                         250       260
                  ....*....|....*....|....*.
gi 974301044  250 K----FCLVYFTIQMSVYGVVFYLPT 271
Cdd:TIGR00895 250 RitvlLWLLYFMLLVGVYFLTNWLPK 275
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
21-321 1.53e-06

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 49.96  E-value: 1.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  21 RLLPFLVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVS 100
Cdd:cd17355    3 VVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 101 AAMMFADDAMTFYVLRFLLGVAEAG-FFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifglan 179
Cdd:cd17355   83 VLLALATSLWQLYLLWGLLGGGGAGtLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFG------ 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 180 WQWLFVTEGLLASLVGIAAYFYLVDRPRDAGwlsdeqkralegeLAEEDTRKQARGPHGFLSALRSGQVLKFCLVYFTIQ 259
Cdd:cd17355  157 WRTALLVLALLALLVLVPVLLLLRRRPADLA-------------LRAYDDASPASPGSTLKEALRSASFWLLALAFFLCG 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 974301044 260 MSVYGVVFYLPTRIASFLDGQVGLNVGLitAIPWVCALAVTRLVTRQADRSGQHRQLAVAML 321
Cdd:cd17355  224 FAVVGLIVHLVPYLADRGISPAAAAVAL--ALIGLFNIVGRLLSGWLGDRYSPRRLLAASYA 283
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
63-203 3.23e-06

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 49.15  E-value: 3.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  63 SIFFIGYACFEVPSNLMLHRLGARvwlcrIMVTWGLVSAAM------MFADDAMTFY-VLRFLLGVAEAGFFPGIILYLT 135
Cdd:cd17318   63 SSFFYGYILTQIPGGYLAEKYGAK-----RVLGYSILITALltlltpLAARGGYGALiVLRILQGLAQGVTFPAMHALWA 137
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 974301044 136 YWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifglanWQWLFVTEGLLaSLVGIAAYFYLV 203
Cdd:cd17318  138 KWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLG------WPSIFYIFGGL-GLLWCLLWFFLV 198
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
82-424 3.24e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 49.11  E-value: 3.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  82 RLGARVWLCRIMVTWGLVSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLG 161
Cdd:cd17473   61 RFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVF 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 162 GPLSGWLLEFhgifglaNWQWLFVTEgLLASLVGIAAYFYLVDRPRDAGwlsdeqkralegelaeEDTRKQARGPHGFLS 241
Cdd:cd17473  141 LLLGGALAEI-------GWRAPFLVY-LLALPVLILVLLFLPEPARKSK----------------SAASPGAATAAALPW 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 242 ALrsgqVLKFCLVYFTIQMSVYGVVFYLPTRIASFLDGQvGLNVGLITAIPWVCALAVTRLVTRQADRSGQHRQLAVAML 321
Cdd:cd17473  197 KR----VLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGS-AALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFA 271
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 322 GMAAAGIAASALAgNLGLAVIAFCFAASGFVSVQPLFWTLPTGYLSGAAAASGIALINSLGNLGGFVAPNLKTLMESQFA 401
Cdd:cd17473  272 LMALGFLLLALAS-GLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG 350
                        330       340
                 ....*....|....*....|...
gi 974301044 402 DPRAGMFALAAVGLLGACLLARL 424
Cdd:cd17473  351 GLSGAFLILGVLALVLAIVLLLL 373
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
23-426 3.45e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 48.74  E-value: 3.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  23 LPFLVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAA 102
Cdd:cd17365    1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 103 MMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifglanWQW 182
Cdd:cd17365   81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFG------WRS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 183 LFVTEGLLASLVGIAAyfylvdrprdagwlsdeqkralegelaeedtrkqargphgflsalrsGQVLKFCLVYFTIQMSV 262
Cdd:cd17365  155 VFLLGGVPPLILLPLL-----------------------------------------------RGTLLLWVTFFMGLLLV 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 263 YGVVFYLPTriasfLDGQVGLNVG---LITAIPWVCALAVTRLVTRQADRSGQHRQLAVAMLGMAAAGIAASALAGNLGL 339
Cdd:cd17365  188 YLLNSWLPK-----LMVEAGYSLSqalTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVL 262
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 340 AVIAFCFAASGFVSVQPLFWTLPTGYLSGAAAASGIALINSLGNLGGFVAPNLKTLMESQFADPRAGMFALAAVGLLGAC 419
Cdd:cd17365  263 LYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGAL 342

                 ....*..
gi 974301044 420 LLARLKT 426
Cdd:cd17365  343 AVLLLRL 349
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
63-356 6.49e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 47.97  E-value: 6.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  63 SIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRS 142
Cdd:cd17489   38 GLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSR 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 143 RAQALGLFYFGLPLALVLGGPLSGWLLEFHGIfglanwQWLFVTeGLLASLVGIAAYFYLVDRPRDAGwlsdeqkraleg 222
Cdd:cd17489  118 RGEGIGYYGLATTLAMALGPALGLFLYQHLGF------AVLFIV-AAVLALLALLLVFLVKDPPPVAA------------ 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 223 elaeedtrKQARGPHGFLSALRSGQVLKFCLVYFTIQMSVYGVVFYLPTRIASFLDGQVGLnVGLITAIpwvcALAVTRL 302
Cdd:cd17489  179 --------EEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGL-FFTVYAI----ALLLSRP 245
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 974301044 303 VTRQ-ADRSGQHRQLAVAMLgMAAAGIAASALAGNLGLAVIAFCFAASGFVSVQP 356
Cdd:cd17489  246 FSGKlSDRKGPKTVIIPGLL-LLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFP 299
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
52-218 2.24e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.43  E-value: 2.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  52 GLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAMMFA--DDAMTFYVLRFLLGVAEAGFF-- 127
Cdd:COG2211  260 GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILvl 339
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 128 -----PGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHG-----------IFGLANwqWLFVTEGLLA 191
Cdd:COG2211  340 pwamlADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspsaLTGIRL--LFFLLPAVLL 417
                        170       180
                 ....*....|....*....|....*..
gi 974301044 192 SLVGIAAYFYLVDRPRDAGWLSDEQKR 218
Cdd:COG2211  418 LLAALLLLFYPLTRERHAEIRAELAAR 444
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
114-295 2.35e-05

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 46.66  E-value: 2.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  114 VLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGIfglanWQWLFVTEGLLASL 193
Cdd:TIGR00894 136 FCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWGG-----WPMIFYVFGIVGCA 210
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  194 VGIAAYFYLVDRPRDAGWLSDEQKRALEGELAEEDTRKQARGPhgFLSALRSGQVLKFCLVYFTIQMSVYGVVFYLPTRI 273
Cdd:TIGR00894 211 WSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQKGSTRQSLP--IKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFI 288
                         170       180
                  ....*....|....*....|....*.
gi 974301044  274 ASFLDGQVGLNvGLITAIP----WVC 295
Cdd:TIGR00894 289 SWVLRVSGKEN-GLLSSLPylfaWLC 313
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
24-197 2.74e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 46.00  E-value: 2.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  24 PFLVLMYVLAFIDRANVGYARAFLQA-DTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAA 102
Cdd:cd17370  201 AFWLYLLAVALFALGNFSFAFLILRAqELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLG 280
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 103 MMFADDAMTFYVLRFLLGV---AEAGFFPGIILYLTywfPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifglan 179
Cdd:cd17370  281 FALGSSLWLLLLGFILWGLymgAQESIERAAVADLV---PAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS------ 351
                        170
                 ....*....|....*...
gi 974301044 180 WQWLFVTEGLLASLVGIA 197
Cdd:cd17370  352 PSAAFLFSAVLALIALLL 369
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
28-207 3.45e-05

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 45.73  E-value: 3.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  28 LMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAMMFAD 107
Cdd:cd17312   10 LGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFST 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 108 DAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifglanWQWLFVTE 187
Cdd:cd17312   90 SLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYG------WRAAFLVP 163
                        170       180
                 ....*....|....*....|
gi 974301044 188 GLLASLVGIAAYFYLVDRPR 207
Cdd:cd17312  164 GIVGLVVAIILFFFLRDSPP 183
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
93-194 3.56e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 45.67  E-value: 3.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  93 MVTWGLVSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGpLSGWLLEFH 172
Cdd:cd17316   73 LLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAA-LVASLLIPL 151
                         90       100
                 ....*....|....*....|..
gi 974301044 173 GIFGLAnWQWLFVTEGLLASLV 194
Cdd:cd17316  152 LSGDWG-WRILFLIGALPALLA 172
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
19-202 4.25e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 42.18  E-value: 4.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  19 RLRLLPFLVLMYVLAFIDRANVGYARAFL----QADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMV 94
Cdd:cd17325  194 LLLRDRRLLALFLAIFVLAFAFGALEPFLplyaAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL 273
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  95 TWGLVSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGi 174
Cdd:cd17325  274 LSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG- 352
                        170       180
                 ....*....|....*....|....*...
gi 974301044 175 fglanWQWLFVTEGLLASLVGIAAYFYL 202
Cdd:cd17325  353 -----FATPFLAAAALLLLAAVLFLLLR 375
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
63-225 6.20e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 41.86  E-value: 6.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  63 SIFFIGYACFEVPSNLMLHRLGARVWLcRIMVTWGLVSAAMMFADDAMTFYVL----RFLLGVAEAGFFPGIILYLTYWF 138
Cdd:cd17357   56 SIFFIGGAIGSFISAFLANRFGRKNGL-LISNALLVVSSLLMFLSKSAKSPELlifgRFLVGIACGLSTGFVPMYLQEIS 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 139 PQRSRaqalGLFYFGLPLALVLGgPLSGWLLEFHGIFGLA-NWQWLFVTEGLLASLVGIAAYFYlvdrPRDAGWLSDEQK 217
Cdd:cd17357  135 PSELR----GALGSLTQIGVTLG-ILLGQVFGLPSVLGTEtLWPYLLFFPGIPALLQLAALPFF----PESPKFLLISKG 205

                 ....*...
gi 974301044 218 RALEGELA 225
Cdd:cd17357  206 DEEEAEKS 213
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
46-207 1.32e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 40.62  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  46 FLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGAR-VWLCRIMVTWGLVS-AAMMFADDAMTFYVLRFLLGVAE 123
Cdd:COG2271  206 YLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrKLVLAIGLLLAALAlLLLALLPSPALAIALLFLAGFGL 285
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 124 AGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifglanWQWLFVTEGLLASLVGIAAYFYLV 203
Cdd:COG2271  286 GGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG------YQAAFLLLAALALLAALLALLLLR 359

                 ....
gi 974301044 204 DRPR 207
Cdd:COG2271  360 ETRK 363
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
47-318 1.76e-03

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 40.36  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044   47 LQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAMMFA-DDAMTFYVLRFLLGVAEAG 125
Cdd:TIGR00886  28 IKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLIRLFIGIAGGS 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  126 FFPGIILyLTYWFPQRSRAQALGLF----YFGLPLALVLGGPLSGWLLEFHGIFGLANWQWLFV-TEGLLASLVGIAAYF 200
Cdd:TIGR00886 108 FASCMPW-ISFFFPKKIQGTALGLAagwgNMGGGVAQFVMPPIIGSLIFGGGQPAHLAWGWAFViVPAGILLLPALLIFF 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  201 YLVDRPRdagwlsdeqkraleGELAEedtrkQARGPHGFLSALRSGQVLKFCLVYFTIQMSVYGVVFYLPTriasFLDGQ 280
Cdd:TIGR00886 187 VGADTPP--------------GKPAT-----GKLSFKEALKVFGNRHTWILALLYSVTFGSFLGVSSIFAM----LFKDQ 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 974301044  281 VGLNvgLITAIPWVCALAVTRLVTRQ-----ADRSGQHRQLAV 318
Cdd:TIGR00886 244 FGLS--KVQAGAYASLGGFLGSLARPaggaiSDRLGGARKLLM 284
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
82-424 2.00e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 40.25  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  82 RLGARVWLCRIMVTWGLVSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLG 161
Cdd:cd17474   60 RFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 162 GPLSGWLlefhgifGLANWQWLFVTEgLLASLVGIAAYFYLVDRPRdagwlsdeqkralegelaEEDTRKQARGPHGFLS 241
Cdd:cd17474  140 PLLGGLL-------AAISWRYPFFLL-AALIPVAFLAILFLLPEPK------------------EKAKSSSATKLRDLKK 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 242 ALRSGQVLKFCLVYFTIQMSVYGVVFYLPTrIASFLDGQVGLNVGLITAIPWVCALAVTRLVTRQADRSGQHRQLAVAML 321
Cdd:cd17474  194 ALRGRGLLTFLVSAFLYFFLYFAFLTYLPF-LLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGL 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 322 GMAAAGIAASALAGNLGLAVIAFCFAASGFVSVQPLFWTLPTGYLSGAAAASGIALINSLGNLGGFVAPNLKTLMESQFa 401
Cdd:cd17474  273 LLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIF- 351
                        330       340
                 ....*....|....*....|...
gi 974301044 402 DPRAGMFALAAVGLLGACLLARL 424
Cdd:cd17474  352 GLSAPFLVGAAIALAAAVLLALL 374
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
93-321 2.02e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 40.29  E-value: 2.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  93 MVTWGLVSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFH 172
Cdd:cd17329   72 LLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 173 GifglanwQWLFVTEGLLASLVGIAAYFYL-VDRPRDAGWLSDEQKRalegelaeedtrkqargphGFLSALRSGQVLKF 251
Cdd:cd17329  152 F-------RLLFLAAAVLFLLAALVLLFLLpETRPKRRAAEKTEILR-------------------GYKIVLRDRAFLLF 205
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044 252 CLVYFTIQMSVYGVVFYLPTRIASFLDGQVGLnVGLITAIPWVCALAVTRLVTRQADRSGQHRQLAVAML 321
Cdd:cd17329  206 LLASFLISLIYFQLESTLPVYVVEILGLGESL-LGLLLALNALLIVLLQFPVARLVERFRLRKILMIGIL 274
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
19-196 3.71e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.12  E-value: 3.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  19 RLRLLPFLVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGL 98
Cdd:cd17316  176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  99 VSAAMMFADDAMTFYVL--RFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGIFG 176
Cdd:cd17316  256 LALPLFYLLSGSPTLLLllLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTG 335
                        170       180
                 ....*....|....*....|
gi 974301044 177 LanWQWLFVTEGLLASLVGI 196
Cdd:cd17316  336 V--PALILALLAIVALIVAL 353
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
21-231 6.45e-03

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 38.47  E-value: 6.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  21 RLLPFLVLM--YVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLMLHRLGARVWLCRIMVTWGL 98
Cdd:cd17343    1 QLTIFASMFvgYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974301044  99 VSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGifgla 178
Cdd:cd17343   81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYG----- 155
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 974301044 179 nWQWLFVTEGLLASLVGIAAYFYLVDRPRDAG---WLSDEQKRALEGELAEEDTRK 231
Cdd:cd17343  156 -WRSTLSISGTVAVVMSVVCLLFIKNEPSDVGlnnIEEEESKGKKKKSPRGESTLK 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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