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Conserved domains on  [gi|984998338|gb|AMC92427|]
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rRNA small subunit methyltransferase G [Mycobacterium tuberculosis]

Protein Classification

16S rRNA (guanine(527)-N(7))-methyltransferase RsmG( domain architecture ID 10495022)

16S rRNA (guanine(527)-N(7))-methyltransferase RsmG specifically methylates the N7 position of guanine in position 527 of 16S rRNA; requires the intact 30S subunit for methylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GidB pfam02527
rRNA small subunit methyltransferase G; This is a family of bacterial glucose inhibited ...
 15-194 1.65e-73

rRNA small subunit methyltransferase G; This is a family of bacterial glucose inhibited division proteins these are probably involved in the regulation of cell devision. GidB has been shown to be a methyltransferase G specific to the rRNA small subunit. Previously identified as a glucose-inhibited division protein B that appears to be present and in a single copy in all complete eubacterial genomes so far sequenced. GidB specifically methylates the N7 position of a guanosine in 16S rRNA.


:

Pssm-ID: 396880  Cd Length: 184  Bit Score: 221.00  E-value: 1.65e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984998338   15 RLGLARRYAEALAGPGVERGLVGPREVGRLWDRHLLNCAVIGELLERG-DRVVDIGSGAGLPGVPLAIARPDLQVVLLEP 93
Cdd:pfam02527   1 QIEKLKRYLQLLLKWNKRYNLTSITEPNELLERHLLDSLVVLEYLDNDrDHVLDVGSGAGFPGIPLAIARPDKKVTLLES 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984998338   94 LLRRTEFLREMVTDLGVA-VEIVRGRAEEswvQDQLGGSDAAVSRAVAALDKLTKWSMPLIRPNGRMLAIKGERAHDEVR 172
Cdd:pfam02527  81 LLKKINFLEEVKSELGLDnVTIVHARAEE---YQPEEQYDVITSRAVASLNELTEWTLPLLKPGGYFLAYKGKQAEDELE 157

                         170       180
                  ....*....|....*....|..
gi 984998338  173 EHRRVMIASGAVDVRVVTCGAN 194
Cdd:pfam02527 158 ELDKACQVLGVEVLSVPSLGAG 179
 
Name Accession Description Interval E-value
GidB pfam02527
rRNA small subunit methyltransferase G; This is a family of bacterial glucose inhibited ...
 15-194 1.65e-73

rRNA small subunit methyltransferase G; This is a family of bacterial glucose inhibited division proteins these are probably involved in the regulation of cell devision. GidB has been shown to be a methyltransferase G specific to the rRNA small subunit. Previously identified as a glucose-inhibited division protein B that appears to be present and in a single copy in all complete eubacterial genomes so far sequenced. GidB specifically methylates the N7 position of a guanosine in 16S rRNA.


Pssm-ID: 396880  Cd Length: 184  Bit Score: 221.00  E-value: 1.65e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984998338   15 RLGLARRYAEALAGPGVERGLVGPREVGRLWDRHLLNCAVIGELLERG-DRVVDIGSGAGLPGVPLAIARPDLQVVLLEP 93
Cdd:pfam02527   1 QIEKLKRYLQLLLKWNKRYNLTSITEPNELLERHLLDSLVVLEYLDNDrDHVLDVGSGAGFPGIPLAIARPDKKVTLLES 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984998338   94 LLRRTEFLREMVTDLGVA-VEIVRGRAEEswvQDQLGGSDAAVSRAVAALDKLTKWSMPLIRPNGRMLAIKGERAHDEVR 172
Cdd:pfam02527  81 LLKKINFLEEVKSELGLDnVTIVHARAEE---YQPEEQYDVITSRAVASLNELTEWTLPLLKPGGYFLAYKGKQAEDELE 157

                         170       180
                  ....*....|....*....|..
gi 984998338  173 EHRRVMIASGAVDVRVVTCGAN 194
Cdd:pfam02527 158 ELDKACQVLGVEVLSVPSLGAG 179
RsmG COG0357
16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ...
 4-210 8.38e-62

16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ribosomal structure and biogenesis]; 16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440126  Cd Length: 211  Bit Score: 191.90  E-value: 8.38e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984998338   4 IEPAASAIFGP----RLGLARRYAEALAGPGVERGLVGPREVGRLWDRHLLNCAVIGELLER-GDRVVDIGSGAGLPGVP 78
Cdd:COG0357    5 LEEGLAELGLElseeQLEQLEAYLELLLKWNKKINLTAIRDPEELWERHILDSLALLPLLPKeGARVLDVGSGAGFPGIP 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984998338  79 LAIARPDLQVVLLEPLLRRTEFLREMVTDLGVA-VEIVRGRAEESWVQDQLggsDAAVSRAVAALDKLTKWSMPLIRPNG 157
Cdd:COG0357   85 LAIARPDLQVTLVDSLGKKIAFLREVVRELGLKnVTVVHGRAEELAPREKF---DVVTARAVAPLPDLLELALPLLKPGG 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 984998338 158 RMLAIKGERAHDEVREHRRVMiasgAVDVRVVTCGANYLRPPATVVFARRGKQ 210
Cdd:COG0357  162 RLLALKGPDAEEELAEAPKAL----KVLEEVEELTLPGLDAERHLVVIKKIKR 210
rsmG_gidB TIGR00138
16S rRNA (guanine(527)-N(7))-methyltransferase RsmG; RsmG was previously called GidB ...
 35-194 2.49e-47

16S rRNA (guanine(527)-N(7))-methyltransferase RsmG; RsmG was previously called GidB (glucose-inhibited division protein B). It is present and a single copy in nearly all complete eubacterial genomes. It is missing only from some obligate intracellular species of various lineages (Chlamydiae, Ehrlichia, Wolbachia, Anaplasma, Buchnera, etc.). RsmG shows a methytransferase fold in its the crystal structure, and acts as a 7-methylguanosine (m(7)G) methyltransferase, apparently specific to 16S rRNA. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 272928  Cd Length: 181  Bit Score: 153.95  E-value: 2.49e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984998338   35 LVGPREVGRLWDRHLLNCAVIGELLErGDRVVDIGSGAGLPGVPLAIARPDLQVVLLEPLLRRTEFLREMVTDLGVA-VE 113
Cdd:TIGR00138  17 LTSIKTPEEIWQRHILDSLALLPYLD-GKRVIDIGSGAGFPGIPLAIARPELKLTLLESNHKKVAFLREVKAELGLNnVE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984998338  114 IVRGRAEEswvQDQLGGSDAAVSRAVAALDKLTKWSMPLIRPNGRMLAIKGERAHDEVREHRRVMIASGAVDVRVVTCGA 193
Cdd:TIGR00138  96 IVNGRAED---YQHEEQFDIITSRALASLNVLLELTLNLLKVGGYFLAYKGKKYLDEIEEAKEKIQVLGVEPLEVPPLTG 172


                  .
gi 984998338  194 N 194
Cdd:TIGR00138 173 P 173
 
Name Accession Description Interval E-value
GidB pfam02527
rRNA small subunit methyltransferase G; This is a family of bacterial glucose inhibited ...
 15-194 1.65e-73

rRNA small subunit methyltransferase G; This is a family of bacterial glucose inhibited division proteins these are probably involved in the regulation of cell devision. GidB has been shown to be a methyltransferase G specific to the rRNA small subunit. Previously identified as a glucose-inhibited division protein B that appears to be present and in a single copy in all complete eubacterial genomes so far sequenced. GidB specifically methylates the N7 position of a guanosine in 16S rRNA.


Pssm-ID: 396880  Cd Length: 184  Bit Score: 221.00  E-value: 1.65e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984998338   15 RLGLARRYAEALAGPGVERGLVGPREVGRLWDRHLLNCAVIGELLERG-DRVVDIGSGAGLPGVPLAIARPDLQVVLLEP 93
Cdd:pfam02527   1 QIEKLKRYLQLLLKWNKRYNLTSITEPNELLERHLLDSLVVLEYLDNDrDHVLDVGSGAGFPGIPLAIARPDKKVTLLES 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984998338   94 LLRRTEFLREMVTDLGVA-VEIVRGRAEEswvQDQLGGSDAAVSRAVAALDKLTKWSMPLIRPNGRMLAIKGERAHDEVR 172
Cdd:pfam02527  81 LLKKINFLEEVKSELGLDnVTIVHARAEE---YQPEEQYDVITSRAVASLNELTEWTLPLLKPGGYFLAYKGKQAEDELE 157

                         170       180
                  ....*....|....*....|..
gi 984998338  173 EHRRVMIASGAVDVRVVTCGAN 194
Cdd:pfam02527 158 ELDKACQVLGVEVLSVPSLGAG 179
RsmG COG0357
16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ...
 4-210 8.38e-62

16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ribosomal structure and biogenesis]; 16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440126  Cd Length: 211  Bit Score: 191.90  E-value: 8.38e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984998338   4 IEPAASAIFGP----RLGLARRYAEALAGPGVERGLVGPREVGRLWDRHLLNCAVIGELLER-GDRVVDIGSGAGLPGVP 78
Cdd:COG0357    5 LEEGLAELGLElseeQLEQLEAYLELLLKWNKKINLTAIRDPEELWERHILDSLALLPLLPKeGARVLDVGSGAGFPGIP 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984998338  79 LAIARPDLQVVLLEPLLRRTEFLREMVTDLGVA-VEIVRGRAEESWVQDQLggsDAAVSRAVAALDKLTKWSMPLIRPNG 157
Cdd:COG0357   85 LAIARPDLQVTLVDSLGKKIAFLREVVRELGLKnVTVVHGRAEELAPREKF---DVVTARAVAPLPDLLELALPLLKPGG 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 984998338 158 RMLAIKGERAHDEVREHRRVMiasgAVDVRVVTCGANYLRPPATVVFARRGKQ 210
Cdd:COG0357  162 RLLALKGPDAEEELAEAPKAL----KVLEEVEELTLPGLDAERHLVVIKKIKR 210
rsmG_gidB TIGR00138
16S rRNA (guanine(527)-N(7))-methyltransferase RsmG; RsmG was previously called GidB ...
 35-194 2.49e-47

16S rRNA (guanine(527)-N(7))-methyltransferase RsmG; RsmG was previously called GidB (glucose-inhibited division protein B). It is present and a single copy in nearly all complete eubacterial genomes. It is missing only from some obligate intracellular species of various lineages (Chlamydiae, Ehrlichia, Wolbachia, Anaplasma, Buchnera, etc.). RsmG shows a methytransferase fold in its the crystal structure, and acts as a 7-methylguanosine (m(7)G) methyltransferase, apparently specific to 16S rRNA. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 272928  Cd Length: 181  Bit Score: 153.95  E-value: 2.49e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984998338   35 LVGPREVGRLWDRHLLNCAVIGELLErGDRVVDIGSGAGLPGVPLAIARPDLQVVLLEPLLRRTEFLREMVTDLGVA-VE 113
Cdd:TIGR00138  17 LTSIKTPEEIWQRHILDSLALLPYLD-GKRVIDIGSGAGFPGIPLAIARPELKLTLLESNHKKVAFLREVKAELGLNnVE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984998338  114 IVRGRAEEswvQDQLGGSDAAVSRAVAALDKLTKWSMPLIRPNGRMLAIKGERAHDEVREHRRVMIASGAVDVRVVTCGA 193
Cdd:TIGR00138  96 IVNGRAED---YQHEEQFDIITSRALASLNVLLELTLNLLKVGGYFLAYKGKKYLDEIEEAKEKIQVLGVEPLEVPPLTG 172


                  .
gi 984998338  194 N 194
Cdd:TIGR00138 173 P 173
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 59-161 5.73e-05

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 41.55  E-value: 5.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984998338   59 LERGDRVVDIGSGAGLPGVPLAIARPDLQVVLLEPLLRRTEFLREMVTDLGV-AVEIVRGRAEESwVQDQLGGSDAA-VS 136
Cdd:TIGR02469  17 LRPGDVLWDIGAGTGSVTIEAARLVPNGRVYAIERNPEALDLIERNLRRFGVsNIVIVEGDAPEA-PEALLPDPDAVfVG 95

                          90       100
                  ....*....|....*....|....*
gi 984998338  137 RAVAALDKLTKWSMPLIRPNGRMLA 161
Cdd:TIGR02469  96 GSGGLLQEILEAVERRLRPGGRIVL 120
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 61-157 1.74e-03

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 37.86  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984998338  61 RGDRVVDIGSGAGLPGVPLAIA-RPDLQVVLLEPLLRRTEFLREMVTDLGVA--VEIVRGRAEEsWVQDQLGGS------ 131
Cdd:COG4122   16 GAKRILEIGTGTGYSTLWLARAlPDDGRLTTIEIDPERAAIARENFARAGLAdrIRLILGDALE-VLPRLADGPfdlvfi 94

                         90       100
                 ....*....|....*....|....*.
gi 984998338 132 DAAVSRAVAALDkltkWSMPLIRPNG 157
Cdd:COG4122   95 DADKSNYPDYLE----LALPLLRPGG 116
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 40-121 5.29e-03

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 36.13  E-value: 5.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984998338  40 EVGRLWDRHllnCAVIGEL-LERGDRVVDIGSGAGLpgVPLAIARPDLQVVLLEPLLRRTEFLREMVTDLGVAVEIVRGR 118
Cdd:COG2226    3 RVAARYDGR---EALLAALgLRPGARVLDLGCGTGR--LALALAERGARVTGVDISPEMLELARERAAEAGLNVEFVVGD 77


                 ...
gi 984998338 119 AEE 121
Cdd:COG2226   78 AED 80
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 61-117 8.19e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 36.03  E-value: 8.19e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 984998338   61 RGDRVVDIGSGAGLPGVPLAIARPDLQVVLLEPLLRRTEFLREMVTDLGV-AVEIVRG 117
Cdd:pfam05175  31 LSGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLeNGEVVAS 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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