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Conserved domains on  [gi|985003012|gb|AMC97098|]
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aspartate carbamoyltransferase catalytic subunit [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

aspartate carbamoyltransferase( domain architecture ID 11489502)

aspartate carbamoyltransferase catalyzes the conversion of aspartate and carbamoyl phosphate to carbamoyl-L-aspartate, the first unique step of pyrimidine biosynthesis

CATH:  3.40.50.1370
EC:  2.1.3.2
Gene Ontology:  GO:0004070|GO:0006520|GO:0016597|GO:0016743
SCOP:  4000794

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
asp_carb_tr TIGR00670
aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB ...
 8-306 4.88e-171

aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB encodes the catalytic chain of aspartate carbamoyltransferase, an enzyme of pyrimidine biosynthesis, which organizes into trimers. In some species, including E. coli and the Archaea but excluding Bacillus subtilis, a regulatory subunit PyrI is also present in an allosterically regulated hexameric holoenzyme. Several molecular weight classes of ATCase are described in MEDLINE:96303527 and often vary within taxa. PyrB and PyrI are fused in Thermotoga maritima.Ornithine carbamoyltransferases are in the same superfamily and form an outgroup. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


:

Pssm-ID: 273209 [Multi-domain]  Cd Length: 301  Bit Score: 476.08  E-value: 4.88e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012    8 KHIISINDLSRDDLNLVLATAAKLKANPQPE----LLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLg 83
Cdd:TIGR00670   1 RHLISISDLSREEIELLLETARELEQVLNGKeplkLLKGKILANLFFEPSTRTRLSFETAMKRLGGSVVNFSDSETSSV- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   84 KKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSgNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGD 163
Cdd:TIGR00670  80 AKGETLADTIKTLSGYVDAIVIRHPLEGAARLAAEVS-EVPVINAGDGSNQHPTQTLLDLYTIYEEFGRLDGLKIALVGD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  164 LKYGRTVHSLTQALAKFdGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERL-DPSEYA 242
Cdd:TIGR00670 159 LKYGRTVHSLAEALTRF-GVEVYLISPEELRMPKEILEELKAKGIKVRETESLEEVIDEADVLYVTRIQKERFpDPEEYE 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985003012  243 NVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVLN 306
Cdd:TIGR00670 238 KVKGSYGITLERLEAAKKGVIIMHPLPRVDEIDPSVDDTPHAKYFKQAFNGVPVRMALLALLLG 301
 
Name Accession Description Interval E-value
asp_carb_tr TIGR00670
aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB ...
 8-306 4.88e-171

aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB encodes the catalytic chain of aspartate carbamoyltransferase, an enzyme of pyrimidine biosynthesis, which organizes into trimers. In some species, including E. coli and the Archaea but excluding Bacillus subtilis, a regulatory subunit PyrI is also present in an allosterically regulated hexameric holoenzyme. Several molecular weight classes of ATCase are described in MEDLINE:96303527 and often vary within taxa. PyrB and PyrI are fused in Thermotoga maritima.Ornithine carbamoyltransferases are in the same superfamily and form an outgroup. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273209 [Multi-domain]  Cd Length: 301  Bit Score: 476.08  E-value: 4.88e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012    8 KHIISINDLSRDDLNLVLATAAKLKANPQPE----LLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLg 83
Cdd:TIGR00670   1 RHLISISDLSREEIELLLETARELEQVLNGKeplkLLKGKILANLFFEPSTRTRLSFETAMKRLGGSVVNFSDSETSSV- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   84 KKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSgNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGD 163
Cdd:TIGR00670  80 AKGETLADTIKTLSGYVDAIVIRHPLEGAARLAAEVS-EVPVINAGDGSNQHPTQTLLDLYTIYEEFGRLDGLKIALVGD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  164 LKYGRTVHSLTQALAKFdGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERL-DPSEYA 242
Cdd:TIGR00670 159 LKYGRTVHSLAEALTRF-GVEVYLISPEELRMPKEILEELKAKGIKVRETESLEEVIDEADVLYVTRIQKERFpDPEEYE 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985003012  243 NVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVLN 306
Cdd:TIGR00670 238 KVKGSYGITLERLEAAKKGVIIMHPLPRVDEIDPSVDDTPHAKYFKQAFNGVPVRMALLALLLG 301
pyrB PRK00856
aspartate carbamoyltransferase catalytic subunit;
3-308 2.02e-156

aspartate carbamoyltransferase catalytic subunit;


Pssm-ID: 234849 [Multi-domain]  Cd Length: 305  Bit Score: 439.12  E-value: 2.02e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   3 NPLYQKHIISINDLSRDDLNLVLATAAKLKANP-----QPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDS 77
Cdd:PRK00856   1 NPLKMKHLLSIEDLSREEIELLLDTAEEFKEVLrrevkKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  78 ANTSlgKKGETLADTISVISTY-VDAIVMRHPQEGAARLATEFSgNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNL 156
Cdd:PRK00856  81 TSSV--SKGETLADTIRTLSAMgADAIVIRHPQSGAARLLAESS-DVPVINAGDGSHQHPTQALLDLLTIREEFGRLEGL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 157 HVAMVGDLKYGRTVHSLTQALAKFdGNRFYFIAPDALaMPQYILDmldekgiaWSLHSSIEEVMAEVDILYMTRVQKERL 236
Cdd:PRK00856 158 KVAIVGDIKHSRVARSNIQALTRL-GAEVRLIAPPTL-LPEGMPE--------YGVHTDLDEVIEDADVVMMLRVQKERM 227

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 985003012 237 D---PSEYANVKAQFVLRASDLHNAKANMKVLHPLP--RVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVLNRD 308
Cdd:PRK00856 228 DgglLPSYEEYKRSYGLTAERLALAKPDAIVMHPGPvnRGVEIASDVADGPQSVIFEQVTNGVAVRMAVLELLLGGR 304
PyrB COG0540
Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; ...
 3-308 6.06e-155

Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; Aspartate carbamoyltransferase, catalytic subunit is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440306 [Multi-domain]  Cd Length: 306  Bit Score: 435.25  E-value: 6.06e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   3 NPLYQKHIISINDLSRDDLNLVLATAAKLKANPQPE----LLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSdSA 78
Cdd:COG0540    1 MSFKMRHLLSIEDLSREEIEELLDTAEEFKEVLRPIkkvpLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFS-AS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  79 NTSLgKKGETLADTISVISTY-VDAIVMRHPQEGAARLATEFSgNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLH 157
Cdd:COG0540   80 TSSV-SKGESLADTIRTLEAYgADAIVIRHPQEGAARLLAEHV-DVPVINAGDGAHEHPTQALLDLYTIREEFGRLDGLK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 158 VAMVGDLKYGRTVHSLTQALAKFdGNRFYFIAPDALaMPQYIldmlDEKGIawSLHSSIEEVMAEVDILYMTRVQKERLD 237
Cdd:COG0540  158 VAIVGDLKHSRVARSNIKALSKL-GAEVTLVAPPTL-LPEEI----EELGV--EVTTDLDEALPDADVVYMLRIQKERFT 229

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985003012 238 ---PSEYANVKAQFVLRASDLHNAKANMKVLHPLP--RVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVLNRD 308
Cdd:COG0540  230 dglFPSYREYKRSYGLTAERLALAKPDAIVMHPGPrnRGVEIDSDVDDTPRSVIFEQVTNGVAVRMALLYLLLGGE 305
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
9-148 3.41e-58

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 183.40  E-value: 3.41e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012    9 HIISINDLSRDDLNLVLATAAKLKANPQ----PELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFsDSANTSLGk 84
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKrgkkLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYL-SSSDIQLS- 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 985003012   85 KGETLADTISVISTYVDAIVMRHP-QEGAARLAtEFSGnVPVLNAGdGSNQHPTQTLLDLFTIQE 148
Cdd:pfam02729  79 SGESLADTARVLSRYVDAIVIRHFgHEDLEELA-EYAS-VPVINAG-GDHEHPTQALADLLTIRE 140
 
Name Accession Description Interval E-value
asp_carb_tr TIGR00670
aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB ...
 8-306 4.88e-171

aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB encodes the catalytic chain of aspartate carbamoyltransferase, an enzyme of pyrimidine biosynthesis, which organizes into trimers. In some species, including E. coli and the Archaea but excluding Bacillus subtilis, a regulatory subunit PyrI is also present in an allosterically regulated hexameric holoenzyme. Several molecular weight classes of ATCase are described in MEDLINE:96303527 and often vary within taxa. PyrB and PyrI are fused in Thermotoga maritima.Ornithine carbamoyltransferases are in the same superfamily and form an outgroup. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273209 [Multi-domain]  Cd Length: 301  Bit Score: 476.08  E-value: 4.88e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012    8 KHIISINDLSRDDLNLVLATAAKLKANPQPE----LLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLg 83
Cdd:TIGR00670   1 RHLISISDLSREEIELLLETARELEQVLNGKeplkLLKGKILANLFFEPSTRTRLSFETAMKRLGGSVVNFSDSETSSV- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   84 KKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSgNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGD 163
Cdd:TIGR00670  80 AKGETLADTIKTLSGYVDAIVIRHPLEGAARLAAEVS-EVPVINAGDGSNQHPTQTLLDLYTIYEEFGRLDGLKIALVGD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  164 LKYGRTVHSLTQALAKFdGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERL-DPSEYA 242
Cdd:TIGR00670 159 LKYGRTVHSLAEALTRF-GVEVYLISPEELRMPKEILEELKAKGIKVRETESLEEVIDEADVLYVTRIQKERFpDPEEYE 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985003012  243 NVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVLN 306
Cdd:TIGR00670 238 KVKGSYGITLERLEAAKKGVIIMHPLPRVDEIDPSVDDTPHAKYFKQAFNGVPVRMALLALLLG 301
pyrB PRK00856
aspartate carbamoyltransferase catalytic subunit;
3-308 2.02e-156

aspartate carbamoyltransferase catalytic subunit;


Pssm-ID: 234849 [Multi-domain]  Cd Length: 305  Bit Score: 439.12  E-value: 2.02e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   3 NPLYQKHIISINDLSRDDLNLVLATAAKLKANP-----QPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDS 77
Cdd:PRK00856   1 NPLKMKHLLSIEDLSREEIELLLDTAEEFKEVLrrevkKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  78 ANTSlgKKGETLADTISVISTY-VDAIVMRHPQEGAARLATEFSgNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNL 156
Cdd:PRK00856  81 TSSV--SKGETLADTIRTLSAMgADAIVIRHPQSGAARLLAESS-DVPVINAGDGSHQHPTQALLDLLTIREEFGRLEGL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 157 HVAMVGDLKYGRTVHSLTQALAKFdGNRFYFIAPDALaMPQYILDmldekgiaWSLHSSIEEVMAEVDILYMTRVQKERL 236
Cdd:PRK00856 158 KVAIVGDIKHSRVARSNIQALTRL-GAEVRLIAPPTL-LPEGMPE--------YGVHTDLDEVIEDADVVMMLRVQKERM 227

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 985003012 237 D---PSEYANVKAQFVLRASDLHNAKANMKVLHPLP--RVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVLNRD 308
Cdd:PRK00856 228 DgglLPSYEEYKRSYGLTAERLALAKPDAIVMHPGPvnRGVEIASDVADGPQSVIFEQVTNGVAVRMAVLELLLGGR 304
PyrB COG0540
Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; ...
 3-308 6.06e-155

Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; Aspartate carbamoyltransferase, catalytic subunit is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440306 [Multi-domain]  Cd Length: 306  Bit Score: 435.25  E-value: 6.06e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   3 NPLYQKHIISINDLSRDDLNLVLATAAKLKANPQPE----LLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSdSA 78
Cdd:COG0540    1 MSFKMRHLLSIEDLSREEIEELLDTAEEFKEVLRPIkkvpLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFS-AS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  79 NTSLgKKGETLADTISVISTY-VDAIVMRHPQEGAARLATEFSgNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLH 157
Cdd:COG0540   80 TSSV-SKGESLADTIRTLEAYgADAIVIRHPQEGAARLLAEHV-DVPVINAGDGAHEHPTQALLDLYTIREEFGRLDGLK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 158 VAMVGDLKYGRTVHSLTQALAKFdGNRFYFIAPDALaMPQYIldmlDEKGIawSLHSSIEEVMAEVDILYMTRVQKERLD 237
Cdd:COG0540  158 VAIVGDLKHSRVARSNIKALSKL-GAEVTLVAPPTL-LPEEI----EELGV--EVTTDLDEALPDADVVYMLRIQKERFT 229

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985003012 238 ---PSEYANVKAQFVLRASDLHNAKANMKVLHPLP--RVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVLNRD 308
Cdd:COG0540  230 dglFPSYREYKRSYGLTAERLALAKPDAIVMHPGPrnRGVEIDSDVDDTPRSVIFEQVTNGVAVRMALLYLLLGGE 305
PLN02527 PLN02527
aspartate carbamoyltransferase
 8-305 2.13e-114

aspartate carbamoyltransferase


Pssm-ID: 178142 [Multi-domain]  Cd Length: 306  Bit Score: 332.87  E-value: 2.13e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   8 KHIISINDLSRDDLNLVLATAAKL----KANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLG 83
Cdd:PLN02527   1 SDVIEAQQFDREMLELLFEVAREMekveRGSPGSQMLKGYLMATLFYEPSTRTRLSFESAMKRLGGEVLTTENAGEFSSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  84 KKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSgNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGD 163
Cdd:PLN02527  81 AKGETLEDTIRTVEGYSDIIVLRHFESGAARRAAATA-EIPVINAGDGPGQHPTQALLDVYTIQREIGRLDGIKVGLVGD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 164 LKYGRTVHSLTQALAKFDGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERLD--PSEY 241
Cdd:PLN02527 160 LANGRTVRSLAYLLAKYEDVKIYFVAPDVVKMKDDIKDYLTSKGVEWEESSDLMEVASKCDVLYQTRIQRERFGerIDLY 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985003012 242 ANVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVL 305
Cdd:PLN02527 240 EAARGKYIVDKKVMDVLPKHAVVMHPLPRLDEITTDVDSDPRAAYFRQAKNGLFIRMALLKLLL 303
PRK08192 PRK08192
aspartate carbamoyltransferase; Provisional
 9-305 8.86e-90

aspartate carbamoyltransferase; Provisional


Pssm-ID: 169269 [Multi-domain]  Cd Length: 338  Bit Score: 271.21  E-value: 8.86e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   9 HIISINDLSRDDLNLVLATAAKLkanpQPELLKHK--------VIASCFFEASTRTRLSFETSMHRLGASV---VGFSDS 77
Cdd:PRK08192   7 HILSVNQLDRDAIQRIFNVADRM----EPYALREKrtrvlegaILGNLFFEPSTRTRVSFGCAFNLLGGHVretTGMASS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  78 ANTslgkKGETLADTISVISTYVDAIVMRHPQEGAARlatEFS--GNVPVLNAGDGSNQHPTQTLLDLFTIQ---ETQGR 152
Cdd:PRK08192  83 SLS----KGESLYDTARVLSTYSDVIAMRHPDAGSVK---EFAegSRVPVINGGDGSNEHPTQALLDLFTIQkelAHAGR 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 153 -LDNLHVAMVGDLKYGRTVHSLTQALAKFDGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRV 231
Cdd:PRK08192 156 gIDGMHIAMVGDLKFGRTVHSLSRLLCMYKNVSFTLVSPKELAMPDYVISDIENAGHKITITDQLEGNLDKADILYLTRI 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 232 QKERLDPSEYANV-KAQFVL-RASDLHNAKANMKVLHPLPR-----VDEIATDVDKTPHAWYFQQAGNGIFARQALLALV 304
Cdd:PRK08192 236 QEERFPSQEEANKyRGKFRLnQSIYTQHCKSNTVIMHPLPRdsraqANELDNDLNSHPNLAIFRQADNGLLIRMALFALT 315


                 .
gi 985003012 305 L 305
Cdd:PRK08192 316 L 316
PRK11891 PRK11891
aspartate carbamoyltransferase; Provisional
 9-305 1.02e-75

aspartate carbamoyltransferase; Provisional


Pssm-ID: 183362 [Multi-domain]  Cd Length: 429  Bit Score: 238.23  E-value: 1.02e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   9 HIISINDLSRDDLNLVLATAAKLkanpQP--------ELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANT 80
Cdd:PRK11891  89 QLLSVDQFSRDSVEALFRVADVM----QPiarrqkisRVLEGAVLGNLFFEASTRTRVSFGAAFCRLGGSVCDTTGFTFS 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  81 SLGKkGETLADTISVISTYVDAIVMRHPQEG-AARLATefSGNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRL----DN 155
Cdd:PRK11891 165 SMAK-GESIYDTSRVMSGYVDALVIRHPEQGsVAEFAR--ATNLPVINGGDGPGEHPSQALLDLYTIQREFSRLgkivDG 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 156 LHVAMVGDLKYGRTVHSLTQALAKFDGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKER 235
Cdd:PRK11891 242 AHIALVGDLKYGRTVHSLVKLLALYRGLKFTLVSPPTLEMPAYIVEQISRNGHVIEQTDDLAAGLRGADVVYATRIQKER 321

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985003012 236 LDPSEYANVKAQFVLRASDLHNA-KANMKVLHPLPR-----VDEIATDVDKTPHAWYFQQAGNGIFARQALLALVL 305
Cdd:PRK11891 322 FADESFEGYTPDFQINQALVDAVcKPDTLIMHPLPRdsrpgANDLSTDLNRDPRLAIFRQTDNGIPVRMAIFAVLL 397
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 3-307 1.26e-58

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 190.26  E-value: 1.26e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   3 NPLYQKHIISINDLSRDDLNLVLATAAKLKANPQ----PELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVgFSDSA 78
Cdd:COG0078    1 TNLKGRHFLSLLDLTPEELRALLDLAAELKAKRKagipHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAI-YLDPG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  79 NTSLGkKGETLADTISVISTYVDAIVMR-HPQEGAARLAtEFSGnVPVLNA-GDGSnqHPTQTLLDLFTIQETQGRLDNL 156
Cdd:COG0078   80 DSQLG-RGESIKDTARVLSRYVDGIMIRtFGHETLEELA-KYAG-VPVINGlTDLF--HPCQALADLLTIREHFGKLKGL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 157 HVAMVGDlkyGRTV-HSLTQALAKFDGNrFYFIAPDALAMPQYILDMLDEKGIAW----SLHSSIEEVMAEVDILY---- 227
Cdd:COG0078  155 KVAYVGD---GNNVaNSLLLAAAKLGMD-VRIATPEGYEPDPEIVAKAKEIAAESggsiTITHDPAEAVKGADVVYtdvw 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 228 --MTrvqkerlDPSEYANVKAQFvlraSD-------LHNAKANMKVLHPLP--RVDEIATDV-DKtPHAWYFQQAGNGIF 295
Cdd:COG0078  231 vsMG-------QEEEAEERIKAF----KPyqvneelMALAKPDAIFMHCLPahRGEEVTDEViDG-PQSVVFDEAENRLH 298

                        330
                 ....*....|..
gi 985003012 296 ARQALLALVLNR 307
Cdd:COG0078  299 AQKALLAWLLGG 310
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
9-148 3.41e-58

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 183.40  E-value: 3.41e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012    9 HIISINDLSRDDLNLVLATAAKLKANPQ----PELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFsDSANTSLGk 84
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKrgkkLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYL-SSSDIQLS- 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 985003012   85 KGETLADTISVISTYVDAIVMRHP-QEGAARLAtEFSGnVPVLNAGdGSNQHPTQTLLDLFTIQE 148
Cdd:pfam02729  79 SGESLADTARVLSRYVDAIVIRHFgHEDLEELA-EYAS-VPVINAG-GDHEHPTQALADLLTIRE 140
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 8-305 1.31e-48

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 164.11  E-value: 1.31e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   8 KHIISINDLSRDDLNLVLATAAKLKANPQ----PELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVgFSDSANTSLG 83
Cdd:PRK00779   5 RHFLSLDDLSPEELEELLDLAAELKKKRKagepHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAI-FLSPRDTQLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  84 kKGETLADTISVISTYVDAIVMR-HPQEGAARLAtEFSgNVPVLNA-GDGSnqHPTQTLLDLFTIQETQGRLDNLHVAMV 161
Cdd:PRK00779  84 -RGEPIEDTARVLSRYVDAIMIRtFEHETLEELA-EYS-TVPVINGlTDLS--HPCQILADLLTIYEHRGSLKGLKVAWV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 162 GDlkyGRTV-HSLTQALAKFDGNrFYFIAPDALAMPQYILDML-DEKGIAWSLHSSIEEVMAEVDILYmTRV-------- 231
Cdd:PRK00779 159 GD---GNNVaNSLLLAAALLGFD-LRVATPKGYEPDPEIVEKIaKETGASIEVTHDPKEAVKGADVVY-TDVwvsmgqea 233

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 985003012 232 -QKERLdpseyaNVKAQFVLRASDLHNAKANMKVLHPLP--RVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVL 305
Cdd:PRK00779 234 eAEERL------KAFAPYQVNEELMALAKPDAIFMHCLPahRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWLL 304
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 8-306 8.32e-45

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 154.43  E-value: 8.32e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012    8 KHIISINDLSRDDLNLVLATAAKLK----ANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSaNTSLG 83
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKkgkkKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPN-DLQLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   84 kKGETLADTISVISTYVDAIVMR-HPQEGAARLAtEFSGnVPVLNAgdGSNQ-HPTQTLLDLFTIQETQGRLDNLHVAMV 161
Cdd:TIGR00658  80 -RGESIKDTARVLSRYVDGIMARvYKHEDVEELA-KYAS-VPVING--LTDLfHPCQALADLLTIIEHFGKLKGVKVVYV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  162 GDlkyGRTV-HSLTQALAKFdGNRFYFIAPDALAMPQYILDM----LDEKGIAWSLHSSIEEVMAEVDILYmTRVQKERL 236
Cdd:TIGR00658 155 GD---GNNVcNSLMLAGAKL-GMDVVVATPEGYEPDADIVKKaqeiAKENGGSVELTHDPVEAVKGADVIY-TDVWVSMG 229

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 985003012  237 DPSEYANVKAQFV---LRASDLHNAKANMKVLHPLPRV--DEIATDVDKTPHAWYFQQAGNGIFARQALLALVLN 306
Cdd:TIGR00658 230 EEDKKEERLKLFRpyqVNEELMELAKPEVIFMHCLPAHrgEEVTDEVIEGPHSIVFDQAENRLHAQKAVMVALLG 304
pyrB PRK13376
bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase ...
 49-304 1.08e-41

bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; Provisional


Pssm-ID: 237369 [Multi-domain]  Cd Length: 525  Bit Score: 151.07  E-value: 1.08e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  49 FFEASTRTRLSFETS--MHRlGASVVGFsDSANTSLGKKgETLADTISVISTYVDA--IVMRHPQEGAARL----ATEFS 120
Cdd:PRK13376  57 FVEPSTRTKESFINAakFHK-NVKVNIF-DSEHSSFNKQ-ESYTDTFNMLTGYSDYsiFIVRTRLEGVCRLleekVSEFA 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 121 --GNVPV---LNAGDGSNQHPTQTLLDLFTIQEtQGRLDN--LHVAMVGDLKYGRTVHSLTQALAKFDGNRFYFIAPDAL 193
Cdd:PRK13376 134 srNGIEVpafINAGDGKHEHPTQELLDEFTFLE-QNNFDNsfIHIALVGDLLHGRTVHSKVNGLKIFKNVKVDLIAPEEL 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 194 AMPQYILDMLDEKGIAWSLHSSIEEVMAEVD---ILYMTRVQKERL--DPSEYANV-KAQFVLRASDLHNAKANMKVLHP 267
Cdd:PRK13376 213 AMPEHYVEKMKKNGFEVRIFSSIEEYLSQKDvakIWYFTRLQLERMgeDILEKEHIlRKAVTFRKEFLDKLPEGVKFYHP 292

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 985003012 268 LPR---VDEIATDVDKTPHAWYFQQAGNGIFARQALLALV 304
Cdd:PRK13376 293 LPRhkvYPTIPTFLDTLPLNGWETQAINGYWVRIVLLSML 332
pyrB PRK13814
aspartate carbamoyltransferase;
9-309 4.60e-40

aspartate carbamoyltransferase;


Pssm-ID: 139876 [Multi-domain]  Cd Length: 310  Bit Score: 142.16  E-value: 4.60e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   9 HIISINDLSRDDLNLVLATA-----AKLKANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVgfSDSANTSLG 83
Cdd:PRK13814   7 HLLNMRSLTRDHIEKLIQRAnyfltQGMEKNSVFETLKGHVVANLFFEPSTRTRNSFEIAAKRLGAMVL--NPNLKISAI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  84 KKGETLADTISVISTY-VDAIVMRHPQ-EGAARLATEFSGNVpVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMV 161
Cdd:PRK13814  85 SKGETLFDTIKTLEAMgVYFFIVRHSEnETPEQIAKQLSSGV-VINAGDGNHQHPSQALIDLMTIKQHKPHWNKLCVTII 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 162 GDLKYGRTVHSLTQALAKFDGNRFYFIAPDALaMPQYILDMLDEKgiawslHSSIEEVMAEVDILYMTRVQKERLDPS-E 240
Cdd:PRK13814 164 GDIRHSRVANSLMDGLVTMGVPEIRLVGPSSL-LPDKVGNDSIKK------FTELKPSLLNSDVIVTLRLQKERHDNSvD 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 985003012 241 YANVKAQFVLRASDLHNAKANMKVLHPLP--RVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVLNRDL 309
Cdd:PRK13814 237 IDAFRGSFRLTPEKLYSAKPDAIVMHPGPvnREVEINSDVADNQQSVILQQVRNGVAMRMAVLELFLLRDF 307
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 1-286 1.42e-32

ornithine carbamoyltransferase; Validated


Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 122.69  E-value: 1.42e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   1 MANPLYQKHIISINDLSRDDLNLVLATAAKLKAN-----PQPeLLKHKVIASCFFEASTRTRLSFETSMHRLGASVVgFS 75
Cdd:PRK02102   1 MAFNLKGRSFLKLLDFTPEEIEYLIDLSIELKAAkkagiEHQ-YLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVT-YL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  76 DSANTSLGKKgETLADTISVISTYVDAIVMR-HPQEGAARLAtEFSGnVPVLNAGDgSNQHPTQTLLDLFTIQETQGRLD 154
Cdd:PRK02102  79 GPNDSQLGKK-ESIEDTARVLGRMYDGIEYRgFKQEIVEELA-KYSG-VPVWNGLT-DEWHPTQMLADFMTMKEHFGPLK 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 155 NLHVAMVGDlkyGR--TVHSLTQALAKFdGNRFYFIAPDAL----AMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYm 228
Cdd:PRK02102 155 GLKLAYVGD---GRnnMANSLMVGGAKL-GMDVRICAPKELwpeeELVALAREIAKETGAKITITEDPEEAVKGADVIY- 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985003012 229 TRVQKERLDPSEYANVKAQF--------VLRAsdlhNAKANMKVLHPLPRVDEIATDVDKTPHAWY 286
Cdd:PRK02102 230 TDVWVSMGEEDEWEERIKLLkpyqvnmdLMKA----TGNPDVIFMHCLPAFHDTETKVGKEIAEKY 291
OTCace pfam00185
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;
158-304 1.64e-29

Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;


Pssm-ID: 425511 [Multi-domain]  Cd Length: 154  Bit Score: 110.01  E-value: 1.64e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  158 VAMVGDlKYGRTVHSLTQALAKFdGNRFYFIAPDALAMPQYILDML----DEKGIAWSLHSSIEEVMAEVDILYMTRVQ- 232
Cdd:pfam00185   2 IAYVGD-GHNNVAHSLIIAAAKL-GMDVRLATPKGYPPDPEVLDKAkkiaEKSGGSIEITDDPAEAVKGADVVYTDVWQs 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 985003012  233 ----KERLDpsEYAnVKAQFVLRASDLHNAKANMKVLHPLP--RVDEIATDVDKTPHAWYFQQAGNGIFARQALLALV 304
Cdd:pfam00185  80 mgqeKEREE--RLK-AFKPYQVNEELMKLAKKDAIFMHCLPahRGEEVTDDVFDGPRSVVFDQAENRLHAQKALLALL 154
PLN02342 PLN02342
ornithine carbamoyltransferase
 8-306 2.35e-28

ornithine carbamoyltransferase


Pssm-ID: 177976 [Multi-domain]  Cd Length: 348  Bit Score: 111.81  E-value: 2.35e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   8 KHIISINDLSRDDLNLVLATAAKLKA-------NPQPelLKHKVIASCFFEASTRTRLSFETSMHRLGASVVgFSDSANT 80
Cdd:PLN02342  46 KHFLHIDDFDKEEILGLLDRAKEVKAllksgdrSFQP--FKGKSMAMIFTKPSMRTRVSFETGFFLLGGHAL-YLGPDDI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  81 SLGKKGETlADTISVISTYVDAIVMR---HPQegAARLATefSGNVPVLNAGDGSNqHPTQTLLDLFTIQETQGRLDNLH 157
Cdd:PLN02342 123 QLGKREET-RDIARVLSRYNDIIMARvfaHQD--VLDLAE--YSSVPVINGLTDYN-HPCQIMADALTIIEHIGRLEGTK 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 158 VAMVGDlkyGRT-VHSLTQALAKFDgnrFYFIA-------PDAlampqYILDMLDEKGIawslhSSIE------EVMAEV 223
Cdd:PLN02342 197 VVYVGD---GNNiVHSWLLLAAVLP---FHFVCacpkgyePDA-----KTVEKARAAGI-----SKIEitndpaEAVKGA 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 224 DILYmTRV-----QKErldpsEYANVKAQF---VLRASDLHNAKANMKVLHPLP--RVDEIATDVDKTPHAWYFQQAGNG 293
Cdd:PLN02342 261 DVVY-TDVwasmgQKE-----EAEKRKKAFqgfQVNEALMKLAGPQAYFMHCLPaeRGVEVTDGVMEAPNSIVFPQAENR 334

                        330
                 ....*....|...
gi 985003012 294 IFARQALLALVLN 306
Cdd:PLN02342 335 MHAQNAIMLHQLG 347
PRK14805 PRK14805
ornithine carbamoyltransferase; Provisional
 8-306 8.81e-28

ornithine carbamoyltransferase; Provisional


Pssm-ID: 237819 [Multi-domain]  Cd Length: 302  Bit Score: 109.39  E-value: 8.81e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   8 KHIISINDLSRDDLNLVLATAAKLKANPQP--ELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVgFSDSANTSLGKK 85
Cdd:PRK14805   2 KHLLSIKELTQQQLLDLLALAKTIKANPAEyrQALAGKSVVMLFEKPSLRTRVSFDIGINKLGGHCL-YLDQQNGALGKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  86 gETLADTISVISTYVDAIVMR----HPQEGAARlatefSGNVPVLNAGdgSNQ-HPTQTLLDLFTIQETQGRLDNLHVAM 160
Cdd:PRK14805  81 -ESVADFAANLSCWADAIVARvfshSTIEQLAE-----HGSVPVINAL--CDLyHPCQALADFLTLAEQFGDVSKVKLAY 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 161 VGDlkyGRTV-HSLTQALAKFdGNRFYFIAPDALAMPQYILDMLDEK----GIAWSLHSSIEEVmAEVDILYmTRVQKER 235
Cdd:PRK14805 153 VGD---GNNVtHSLMYGAAIL-GATMTVICPPGHFPDGQIVAEAQELaaksGGKLVLTSDIEAI-EGHDAIY-TDTWISM 226

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985003012 236 LDPSEYANVKAQFV---LRASDLHNAKANMkVLHPLP--RVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVLN 306
Cdd:PRK14805 227 GDDTPLAEIKAKFApyqVNKALMEKAGATF-VMHCQPahRGVEITSEVMDGEGSLILQQAENRMHAQNAVLVTLLS 301
PRK03515 PRK03515
ornithine carbamoyltransferase subunit I; Provisional
 3-309 7.76e-25

ornithine carbamoyltransferase subunit I; Provisional


Pssm-ID: 179587 [Multi-domain]  Cd Length: 336  Bit Score: 102.10  E-value: 7.76e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   3 NPLYQKHIISINDLSRDDLNLVLATAAKLKANPQP----ELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSA 78
Cdd:PRK03515   2 NQFYQRHFLRLLDFTPAELNSLLQLAAKLKADKKNgkeeQKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  79 nTSLGKKgETLADTISVISTYVDAIVMR-HPQEGAARLAtEFSGnVPVLNaGDGSNQHPTQTLLDLFTIQETQ-GR-LDN 155
Cdd:PRK03515  82 -SQIGHK-ESIKDTARVLGRMYDGIQYRgYGQEIVETLA-EYAG-VPVWN-GLTNEFHPTQLLADLLTMQEHLpGKaFNE 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 156 LHVAMVGDLKyGRTVHSLTQAlAKFDGNRFYFIAPDALaMPQYIL-----DMLDEKGIAWSLHSSIEEVMAEVDILYmTR 230
Cdd:PRK03515 157 MTLAYAGDAR-NNMGNSLLEA-AALTGLDLRLVAPKAC-WPEAALvtecrALAQKNGGNITLTEDIAEGVKGADFIY-TD 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 231 VQKERLDPSEyanVKAQfvlRASDLHNAKANM-----------KVLHPLPRVD--------------------EIATDVD 279
Cdd:PRK03515 233 VWVSMGEPKE---VWAE---RIALLRPYQVNSkmmqltgnpqvKFLHCLPAFHddqttlgkkmaeeyglhggmEVTDEVF 306

                        330       340       350
                 ....*....|....*....|....*....|
gi 985003012 280 KTPHAWYFQQAGNGIFARQALLALVLNRDL 309
Cdd:PRK03515 307 ESAHSIVFDQAENRLHTIKAVMVATLSKDL 336
PRK04523 PRK04523
N-acetylornithine carbamoyltransferase; Reviewed
 8-307 4.67e-23

N-acetylornithine carbamoyltransferase; Reviewed


Pssm-ID: 235304 [Multi-domain]  Cd Length: 335  Bit Score: 97.13  E-value: 4.67e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   8 KHIISINDLSRDDLNLVLATAAKLKANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFsDSANTSL----- 82
Cdd:PRK04523   4 KHFLNTQDWSRAELDALLTQAAAFKRNKLGSALKGKSIALVFFNPSLRTRTSFELGAFQLGGHAVVL-QPGKDAWpiefe 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  83 ------GKKGETLADTISVISTYVDAIVMR-HPQ-------------EGAARLATefsgnVPVLNAgdGSNQHPTQTLLD 142
Cdd:PRK04523  83 lgavmdGETEEHIREVARVLSRYVDLIGVRaFPKfvdwskdrqdqvlNSFAKYST-----VPVINM--ETITHPCQELAH 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 143 LFTIQETQGRLDNlhvamvgDLKYGRTVHSLTQALAKFDGNRFYFIAPdALAM--------PQYIldmLDEKGIAW---- 210
Cdd:PRK04523 156 ALALQEHFGTTLR-------GKKYVLTWTYHPKPLNTAVANSALLIAT-RLGMdvtllcptPDYI---LDERYMDWaeqn 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 211 --------SLHSSIEEVMAEVDILYmtrvQKERLDPSEYANVKAQFVLRA--------SDLHNAKANMKVLHPLP-RVDE 273
Cdd:PRK04523 225 aaesggslTVSHDIDSAYAGADVVY----AKSWGALPFFGNWEPEKPIRDqyqhfivdERKMALTNNGVFSHCLPlRRNV 300

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 985003012 274 IATD-VDKTPHAWYFQQAGNGIFARQALLALVLNR 307
Cdd:PRK04523 301 KVTDaVMDSPNCIAIDEAENRLHVQKAIMAALASQ 335
PRK04284 PRK04284
ornithine carbamoyltransferase; Provisional
 5-227 9.21e-21

ornithine carbamoyltransferase; Provisional


Pssm-ID: 235269 [Multi-domain]  Cd Length: 332  Bit Score: 90.57  E-value: 9.21e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   5 LYQKHIISINDLSRDDLNLVLATAAKLK----ANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVgFSDSANT 80
Cdd:PRK04284   4 LRNRSFLTLLDFTPKEIEYLLDLSEDLKrakyAGIEVQKLKGKNIALIFEKDSTRTRCAFEVAAYDQGAHVT-YLGPTGS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  81 SLGKKgETLADTISVISTYVDAIVMR-HPQEGAARLAtEFSGnVPVLNaGDGSNQHPTQTLLDLFTIQET-QGRLDNLHV 158
Cdd:PRK04284  83 QMGKK-ESTKDTARVLGGMYDGIEYRgFSQRTVETLA-EYSG-VPVWN-GLTDEDHPTQVLADFLTAKEHlKKPYKDIKF 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 985003012 159 AMVGDlkyGR--TVHSLTQALAKFdGNRFYFIAPDALAMPQYILD----MLDEKGIAWSLHSSIEEVMAEVDILY 227
Cdd:PRK04284 159 TYVGD---GRnnVANALMQGAAIM-GMDFHLVCPKELNPDDELLNkckeIAAETGGKITITDDIDEGVKGSDVIY 229
PRK12562 PRK12562
ornithine carbamoyltransferase subunit F; Provisional
 5-148 2.12e-17

ornithine carbamoyltransferase subunit F; Provisional


Pssm-ID: 105755  Cd Length: 334  Bit Score: 81.26  E-value: 2.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   5 LYQKHIISINDLSRDDLNLVLATAAKLKANP----QPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSAnT 80
Cdd:PRK12562   4 FYKKHFLKLLDFTPAELNSLLQLAAKLKADKkngkEVARLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSG-S 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 985003012  81 SLGKKgETLADTISVISTYVDAIVMR-HPQEGAARLAtEFSGnVPVLNaGDGSNQHPTQTLLDLFTIQE 148
Cdd:PRK12562  83 QIGHK-ESIKDTARVLGRMYDGIQYRgHGQEVVETLA-EYAG-VPVWN-GLTNEFHPTQLLADLLTMQE 147
PRK01713 PRK01713
ornithine carbamoyltransferase; Provisional
 1-301 3.25e-17

ornithine carbamoyltransferase; Provisional


Pssm-ID: 167263 [Multi-domain]  Cd Length: 334  Bit Score: 80.80  E-value: 3.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   1 MANPLYQKHIISINDLSRDDLNLVLATAAKLK----ANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVgFSD 76
Cdd:PRK01713   1 MAFNLKNRHLLSLVNHTEREIKYLLDLSRDLKrakyAGTEQQRLKGKNIALIFEKTSTRTRCAFEVAAYDQGAQVT-YID 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  77 SANTSLGKKgETLADTISVISTYVDAIVMR-HPQEGAARLAtEFSGnVPVLNaGDGSNQHPTQTLLDLFT-IQETQGRLD 154
Cdd:PRK01713  80 PNSSQIGHK-ESMKDTARVLGRMYDAIEYRgFKQSIVNELA-EYAG-VPVFN-GLTDEFHPTQMLADVLTmIENCDKPLS 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 155 NLHVAMVGDLKyGRTVHSLTQALAKFdGNRFYFIAPDALAMPQYILDMLDE-------------------KGIAWsLHSS 215
Cdd:PRK01713 156 EISYVYIGDAR-NNMGNSLLLIGAKL-GMDVRICAPKALLPEASLVEMCEKfakesgaritvtddidkavKGVDF-VHTD 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 216 IEEVMAE--------VDILYMTRVQKERLDPSEYANVKAQFVLRAsdLHNAKANM--KVLHPLPRVD---EIATDVDKTP 282
Cdd:PRK01713 233 VWVSMGEpletwgerIKLLMPYQVTPELMKRTGNPKVKFMHCLPA--FHNSETKVgrQIAEKYPELAngiEVTEDVFESP 310

                        330
                 ....*....|....*....
gi 985003012 283 HAWYFQQAGNGIFARQALL 301
Cdd:PRK01713 311 MNIAFEQAENRMHTIKAVM 329
PRK14804 PRK14804
ornithine carbamoyltransferase; Provisional
 8-305 5.74e-12

ornithine carbamoyltransferase; Provisional


Pssm-ID: 173265 [Multi-domain]  Cd Length: 311  Bit Score: 65.43  E-value: 5.74e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   8 KHIISINDLSRDDLNLVLATAAKLKANpQPELLKH---KVIASCFFEASTRTRLSFETSMHRLGASVVgFSD--SANTSL 82
Cdd:PRK14804   7 KHLISWEDWSDSEILDLLDFAVHVKKN-RVNYAGHmsgRSLAMLFQKTSTRTRVSFEVAMTEMGGHGI-YLDwmASNFQL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  83 GK---KGETLADTISVI----STYVDAIVMRHpqegaarlatefSGNVPVLNAGDgSNQHPTQTLLDLFTI--QETQGRL 153
Cdd:PRK14804  85 SDidlEARYLSRNVSVImarlKKHEDLLVMKN------------GSQVPVINGCD-NMFHPCQSLADIMTIalDSPEIPL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 154 DNLHVAMVGdlKYGRTVHSLTQALAKFdGNRFYFIAPDALA---MPQYIlDMLDEKG-IAWSLhsSIEEVMAEVDILYM- 228
Cdd:PRK14804 152 NQKQLTYIG--VHNNVVNSLIGITAAL-GIHLTLVTPIAAKeniHAQTV-ERAKKKGtLSWEM--NLHKAVSHADYVYTd 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012 229 TRVQKERLDPSEYANVKAQ-------FVLRASDLHnaKANMKVLHPLP--RVDEIATDVDKTPHAWYFQQAGNGIFARQA 299
Cdd:PRK14804 226 TWLDMEFFNDPSYADKKKQrmelmmpYQINSSLME--KTNAKVMHDMPihAGYEITREVVLSDRSIIFQQAENRLDAQKA 303


                 ....*.
gi 985003012 300 LLALVL 305
Cdd:PRK14804 304 VILKLL 309
PRK07200 PRK07200
aspartate/ornithine carbamoyltransferase family protein; Validated
 5-160 1.26e-07

aspartate/ornithine carbamoyltransferase family protein; Validated


Pssm-ID: 235961 [Multi-domain]  Cd Length: 395  Bit Score: 52.43  E-value: 1.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012   5 LYQKHIISINDLSRDDLNLVLATAAKLKA----NPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVV----GFSD 76
Cdd:PRK07200  18 MHEKDFLLTWEKTPDELKAVLDVADALRAlreeNISTKVFNSGLGISVFRDNSTRTRFSYASACNLLGLEVQdldeGKSQ 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003012  77 SANtslgkkGETLADTISVISTYVDAIVMR----------HPQEGAARLATEFSGNV----PVLNAGDGSNQHPTQTLLD 142
Cdd:PRK07200  98 IAH------GETVRETANMISFMADVIGIRddmyigkgnaYMREVGAAVDDGYKQGVlpqrPTLVNLQCDIDHPTQSMAD 171

                        170       180
                 ....*....|....*....|.
gi 985003012 143 LFTIQETQGRLDNLH---VAM 160
Cdd:PRK07200 172 LLHLIEHFGGLENLKgkkIAM 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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