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Conserved domains on  [gi|985003816|gb|AMC97902|]
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transcriptional regulator [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

N-acetylglucosamine repressor( domain architecture ID 20283050)

N-acetylglucosamine repressor acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon

CATH:  3.30.420.40
Gene Ontology:  GO:0003677|GO:0005975|GO:0003700|GO:0006355
PubMed:  8800467|7781919|7952186
SCOP:  3000092

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 86-400 0e+00

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


:

Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 548.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  86 FHAIGVRLGRHDATITLFDLSSKVLAEEHYPLPERTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKI 165
Cdd:cd24075    1 FHILAVRLGRHDLTLGLYDLSGELLAEHTVPLTALNQEALLSQLIEEIAQFLKSHRRKTQRLIAISITLPGLINPKTGVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 166 HYMPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEI 245
Cdd:cd24075   81 HYMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 246 GHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDCTIKTICKAANKGDSLASEVIEYVGRHLGKT 325
Cdd:cd24075  161 GHIQIEPLGERCHCGNFGCLETVASNAAIEQRVKKLLKQGYASQLTLQDCTIKDICQAALNGDQLAQDVIKRAGRYLGKV 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 985003816 326 IAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRSAIGAFALVKRAMLNGILL 400
Cdd:cd24075  241 IAILINLLNPQKIIIAGEITQADKVLLPVIKKCIQSQALPDFRQELKIVASQLDHNSAIGAFALVKRALLEGGLL 315
HTH_ARSR super family cl46857
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 25-77 1.81e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


The actual alignment was detected with superfamily member pfam01047:

Pssm-ID: 481197 [Multi-domain]  Cd Length: 59  Bit Score: 42.15  E-value: 1.81e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 985003816   25 RLIDQYGPISRIQIAEQSQLAPASVTKITRQLIERGLIkevDQQASTGGRRAI 77
Cdd:pfam01047  10 RILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLI---ERSRSPEDRREV 59
 
Name Accession Description Interval E-value
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 86-400 0e+00

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 548.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  86 FHAIGVRLGRHDATITLFDLSSKVLAEEHYPLPERTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKI 165
Cdd:cd24075    1 FHILAVRLGRHDLTLGLYDLSGELLAEHTVPLTALNQEALLSQLIEEIAQFLKSHRRKTQRLIAISITLPGLINPKTGVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 166 HYMPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEI 245
Cdd:cd24075   81 HYMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 246 GHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDCTIKTICKAANKGDSLASEVIEYVGRHLGKT 325
Cdd:cd24075  161 GHIQIEPLGERCHCGNFGCLETVASNAAIEQRVKKLLKQGYASQLTLQDCTIKDICQAALNGDQLAQDVIKRAGRYLGKV 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 985003816 326 IAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRSAIGAFALVKRAMLNGILL 400
Cdd:cd24075  241 IAILINLLNPQKIIIAGEITQADKVLLPVIKKCIQSQALPDFRQELKIVASQLDHNSAIGAFALVKRALLEGGLL 315
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 89-392 1.19e-122

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 357.03  E-value: 1.19e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816   89 IGVRLGRHDATITLFDLSSKVLAEEHYPlpeRTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKIHYM 168
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEILARERVP---TPTTTTEETLVDAIAFFVDSAQRKFGELIAVGIGSPGLISPKYGYITNT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  169 PHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIGHI 248
Cdd:pfam00480  78 PNIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGHI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  249 QVEPLGERCHCGNFGCLETIAANAAIEQRVLNllkqgyqsrvPLDDCTIKTICKAANKGDSLASEVIEYVGRHLGKTIAI 328
Cdd:pfam00480 158 QLDPNGPKCGCGNHGCLETIASGRALEKRYQQ----------KGEDLEGKDIIVLAEQGDEVAEEAVERLARYLAKAIAN 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985003816  329 AINLFNPQKIVIAGEITEADKvLLPAIESCINTQALKAFRTNL--PVVRSELDHRSAIGAFALVKR 392
Cdd:pfam00480 228 LINLFDPQAIVLGGGVSNADG-LLEAIRSLVKKYLNGYLPVPPviIVAASLGDNAGALGAAALAKQ 292
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 87-392 2.20e-91

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 277.55  E-value: 2.20e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  87 HAIGVRLGRHDATITLFDLSSKVLAEEHYPLP-ERTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKI 165
Cdd:COG1940    6 YVIGIDIGGTKIKAALVDLDGEVLARERIPTPaGAGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVDPETGVV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 166 HYMPHIQ-VENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGE 244
Cdd:COG1940   86 LNAPNLPgWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGANGNAGE 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 245 IGHIQVEPLGERCHCGNFGCLETIAANAAIEQRvlnllkqgYQSRVPLDDCTIKTICKAANKGDSLASEVIEYVGRHLGK 324
Cdd:COG1940  166 IGHMPVDPDGPLCGCGNRGCLETYASGPALLRR--------ARELGGAEKLTAEELFAAARAGDPLALEVLDEAARYLGI 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 985003816 325 TIAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRS-AIGAFALVKR 392
Cdd:COG1940  238 GLANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVPASLGDDAgLLGAAALALE 306
ROK_glcA_fam TIGR00744
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ...
 89-395 5.89e-39

ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]


Pssm-ID: 273246 [Multi-domain]  Cd Length: 318  Bit Score: 141.96  E-value: 5.89e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816   89 IGVRLGRHDATITLFDLSSKVLAEEHYPLPeRTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKIHYM 168
Cdd:TIGR00744   1 IGVDIGGTTIKLGVVDEEGNILSKWKVPTD-TTPETIVDAIASAVDSFIQHIAKVGHEIVAIGIGAPGPVNRQRGTVYFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  169 PHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIGHI 248
Cdd:TIGR00744  80 VNLDWKQEPLKEKVEARVGLPVVVENDANAAALGEYKKGAGKGARDVICITLGTGLGGGIIINGEIRHGHNGVGAEIGHI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  249 QVEPLGE-RCHCGNFGCLETIAANAAIeqrvLNLLKQGY------QSRVPL---DDCTIKTICKAANKGDSLASEVIEYV 318
Cdd:TIGR00744 160 RMVPDGRlLCNCGKQGCIETYASATGL----VRYAKRANakperaEVLLALgdgDGISAKHVFVAARQGDPVAVDSYREV 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 985003816  319 GRHLGKTIAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRSAI-GAFALVKRAML 395
Cdd:TIGR00744 236 ARWAGAGLADLASLFNPSAIVLGGGLSDAGDLLLDPIRKSYKRWLFGGARQVADIIAAQLGNDAGLvGAADLARTYII 313
PRK09698 PRK09698
D-allose kinase; Provisional
 119-396 5.91e-29

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 114.69  E-value: 5.91e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 119 ERTQQTLEHALLNAIAQFIDSY-QRKLRELIAISVILPGLVDPDSGKIHYMPHIQV---ENWGLVEALEERFKVTCFVGH 194
Cdd:PRK09698  33 KRTAEVIAPDLVSGLGEMIDEYlRRFNARCHGIVMGFPALVSKDRRTVISTPNLPLtalDLYDLADKLENTLNCPVFFSR 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 195 DIRSLAL--AEHYfgasqDCEDSILVRVHRGTGAG--IISNGRIFIGRNGNVGEIGHIQVEPLGERCHCGNFGCLETIAA 270
Cdd:PRK09698 113 DVNLQLLwdVKEN-----NLTQQLVLGAYLGTGMGfaVWMNGAPWTGAHGVAGELGHIPLGDMTQHCGCGNPGCLETNCS 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 271 NAAieqrvlnlLKQGYQSR---VPLDDCTIKTickaankGDSLAsevIEYVGRHLGKTIAIAINLFNPQKIVIAGEITEA 347
Cdd:PRK09698 188 GMA--------LRRWYEQQprdYPLSDLFVHA-------GDHPF---IQSLLENLARAIATSINLFDPDAIILGGGVMDM 249

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 985003816 348 DKVLLPAIESCINTQALKAF-RTNLPVVRSEL-DHRSAIGAFALVKRAMLN 396
Cdd:PRK09698 250 PAFPRETLIAMIQKYLRKPLpYEVVRFIYASSsDFNGAQGAAILAHQRFLP 300
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 25-77 1.81e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 42.15  E-value: 1.81e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 985003816   25 RLIDQYGPISRIQIAEQSQLAPASVTKITRQLIERGLIkevDQQASTGGRRAI 77
Cdd:pfam01047  10 RILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLI---ERSRSPEDRREV 59
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
25-79 2.94e-05

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 42.58  E-value: 2.94e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 985003816    25 RLIDQYGPISRIQIAEQSQLAPASVTKITRQLIERGLIkevDQQASTGGRRAISI 79
Cdd:smart00347  17 RILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLV---RREPSPEDRRSVLV 68
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
22-63 9.60e-05

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 42.11  E-value: 9.60e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 985003816  22 AVYRLIDQYGPISRIQIAEQSQLAPASVTKITRQLIERGLIK 63
Cdd:COG1321   14 AIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVE 55
 
Name Accession Description Interval E-value
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 86-400 0e+00

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 548.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  86 FHAIGVRLGRHDATITLFDLSSKVLAEEHYPLPERTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKI 165
Cdd:cd24075    1 FHILAVRLGRHDLTLGLYDLSGELLAEHTVPLTALNQEALLSQLIEEIAQFLKSHRRKTQRLIAISITLPGLINPKTGVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 166 HYMPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEI 245
Cdd:cd24075   81 HYMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 246 GHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDCTIKTICKAANKGDSLASEVIEYVGRHLGKT 325
Cdd:cd24075  161 GHIQIEPLGERCHCGNFGCLETVASNAAIEQRVKKLLKQGYASQLTLQDCTIKDICQAALNGDQLAQDVIKRAGRYLGKV 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 985003816 326 IAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRSAIGAFALVKRAMLNGILL 400
Cdd:cd24075  241 IAILINLLNPQKIIIAGEITQADKVLLPVIKKCIQSQALPDFRQELKIVASQLDHNSAIGAFALVKRALLEGGLL 315
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 89-392 1.19e-122

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 357.03  E-value: 1.19e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816   89 IGVRLGRHDATITLFDLSSKVLAEEHYPlpeRTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKIHYM 168
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEILARERVP---TPTTTTEETLVDAIAFFVDSAQRKFGELIAVGIGSPGLISPKYGYITNT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  169 PHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIGHI 248
Cdd:pfam00480  78 PNIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGHI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  249 QVEPLGERCHCGNFGCLETIAANAAIEQRVLNllkqgyqsrvPLDDCTIKTICKAANKGDSLASEVIEYVGRHLGKTIAI 328
Cdd:pfam00480 158 QLDPNGPKCGCGNHGCLETIASGRALEKRYQQ----------KGEDLEGKDIIVLAEQGDEVAEEAVERLARYLAKAIAN 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985003816  329 AINLFNPQKIVIAGEITEADKvLLPAIESCINTQALKAFRTNL--PVVRSELDHRSAIGAFALVKR 392
Cdd:pfam00480 228 LINLFDPQAIVLGGGVSNADG-LLEAIRSLVKKYLNGYLPVPPviIVAASLGDNAGALGAAALAKQ 292
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 86-405 1.79e-112

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 331.97  E-value: 1.79e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  86 FHAIGVRLGRHDATITLFDLSSKVLAEEHYPLPERTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKI 165
Cdd:cd24074    2 WQFLSIRIGRGYITLALRDLNGRLLAEERYPLPAKDNDPFLDRLLESISEFFSRHQKKLERLTAIAITLPGIIDPESGIV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 166 HYMPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEI 245
Cdd:cd24074   82 HRLPFYDIKNLPLGEALEQHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIVIDDDIGAGVITDGQLLHAGSSRLGEL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 246 GHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDCTIKTICKAANKGDSLASEVIEYVGRHLGKT 325
Cdd:cd24074  162 GHTQIDPYGKRCYCGNHGCLETVASIPAILEQANQLLEQSPDSMLHGQPISIESLCQAALAGDPLAQDIIIQVGRHLGRI 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 326 IAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRSAIGAFALVKRAMLNGILLQHLLE 405
Cdd:cd24074  242 LAILVNLFNPEKILIGSPLNNAAEILFPALSQSIRQQSLPAYSQHLQIESTKFYNDGTMPGAALIKDALYDGSLLLKLLQ 321
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 87-392 2.20e-91

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 277.55  E-value: 2.20e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  87 HAIGVRLGRHDATITLFDLSSKVLAEEHYPLP-ERTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKI 165
Cdd:COG1940    6 YVIGIDIGGTKIKAALVDLDGEVLARERIPTPaGAGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVDPETGVV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 166 HYMPHIQ-VENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGE 244
Cdd:COG1940   86 LNAPNLPgWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGANGNAGE 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 245 IGHIQVEPLGERCHCGNFGCLETIAANAAIEQRvlnllkqgYQSRVPLDDCTIKTICKAANKGDSLASEVIEYVGRHLGK 324
Cdd:COG1940  166 IGHMPVDPDGPLCGCGNRGCLETYASGPALLRR--------ARELGGAEKLTAEELFAAARAGDPLALEVLDEAARYLGI 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 985003816 325 TIAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRS-AIGAFALVKR 392
Cdd:COG1940  238 GLANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVPASLGDDAgLLGAAALALE 306
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 87-390 1.98e-74

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 234.00  E-value: 1.98e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  87 HAIGVRLGRHDATITLFDLSSKVLAEEHYPLPER--TQQTLEhALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGK 164
Cdd:cd24076    2 AVIGVELGVDYITVVVTDLAGEVLWRREVPLPASddPDEVLA-QLAALIREALAAAPDSPLGILGIGVGVPGLVDSEDGV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 165 IHYMPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGE 244
Cdd:cd24076   81 VLLAPNLGWRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGASGFAGE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 245 IGHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGyqsrvplDDCTIKTICKAANKGDSLASEVIEYVGRHLGK 324
Cdd:cd24076  161 IGHMTVDPDGPPCSCGNRGCWETYASERALLRAAGRLGAGG-------EPLSLAELVEAARAGDPAALAALEEVGEYLGI 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 985003816 325 TIAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSEL-DHRSAIGAFALV 390
Cdd:cd24076  234 GLANLVNTFNPELVVLGGALAPLGPWLLPPLRAEVARRALPAPARDVRIVVSRLgEDAAALGAAALA 300
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 87-390 1.13e-68

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 219.35  E-value: 1.13e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  87 HAIGVRLGRHDATITLFDLSSKVLAEEHYPLPERTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKIH 166
Cdd:cd24073    2 YVVGVKLTEDRITAVLTDLRGNVLASHTLPLDSGDPEAVAEAIAEAVAELLAQAGLSPDRLLGIGVGLPGLVDAETGICR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 167 YMPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIG 246
Cdd:cd24073   82 WSPLLGWRDVPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGAGEIG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 247 HIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQsrvplddCTIKTICKAANKGDSLASEVIEYVGRHLGKTI 326
Cdd:cd24073  162 HTTVDPDGPPCRCGKRGCLEAYASDPAILRQAREAGLRGEP-------LTIEDLLAAARAGDPAARAILRRAGRALGLAL 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 985003816 327 AIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRS-AIGAFALV 390
Cdd:cd24073  235 ANLVNLLDPELIIISGEGVRAGDLLFEPMREALRAHVFPGLASDLELVIHPWGDEAwARGAAALA 299
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 86-390 2.58e-67

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 215.91  E-value: 2.58e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  86 FHAIGVRLGRHDATITLFDLSSKVLAEEHYPLPErtqQTLEHALLNAIAQFIDSYQRKL---RELIAISVILPGLVDPDS 162
Cdd:cd24059    1 PYVIGVEIGRDLLSAVLCDLSGNILAREKYPLDE---KENPEEVLEKLYELIDRLLEKEnikSKILGIGIGAPGPLDVEK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 163 G---KIHYMPHIqvENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRN 239
Cdd:cd24059   78 GiilNPPNFPGW--ENIPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVD 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 240 GNVGEIGHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQsrvplddcTIKTICKAANKGDSLASEVIEYVG 319
Cdd:cd24059  156 GYAGEIGHTSIDINGPRCSCGNRGCLELYASIPAIEKKARSALGSGRS--------FQLDIVEALQKGDPIADEVIEEAA 227

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 985003816 320 RHLGKTIAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRS-AIGAFALV 390
Cdd:cd24059  228 KYLGIGLVNLINLLNPEAIIIGGELIYLGERYLEPIEKEVNSRLFGRNAREVRILKSSLGEDApLLGAAALV 299
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 87-390 4.07e-56

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 187.11  E-value: 4.07e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  87 HAIGVRLGRHDATITLFDLSSKVLAEEHYPLPERTQqtlEHALLNAIAQFIDSYQRKLRE---LIAISVILPGLVDPDSG 163
Cdd:cd24071    2 YIIGVKIEEGYLVLALTDLKGKILEKTRIPFDHETD---PEKVIELIAENIKKLIKNKHVekkLLGIGIAVSGLVDSKKG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 164 KIHYMPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVG 243
Cdd:cd24071   79 IVIRSTILGWENVELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNFGGAG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 244 EIGHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVP-LDDCTIKTICKAANKGDSLASEVIEYVGRHL 322
Cdd:cd24071  159 EIGHMTIQPDGRKCYCGQKGCLEAYASFEALVNEIKELTESYPLSLLKeLEDFEIEKVREAAEEGDSVATELFKKAGEYL 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 985003816 323 GKTIAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRS-AIGAFALV 390
Cdd:cd24071  239 GIGIKNLINIFNPEAIIIGGEGLEFKDYFLPKIIEIAKENFFGKAGRNVIILVDSLGEDAwVLGAALLV 307
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 89-389 2.52e-54

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 179.97  E-value: 2.52e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  89 IGVRLGRHDATITLFDLSSKVLAEEHYPLPERTQQtleHALLNAIAQFIDSYQRKLR---ELIAISVILPGLVDPDSGKI 165
Cdd:cd23763    1 IGIDIGGTKIRAALVDLDGEILARERVPTPAEEGP---EAVLDRIAELIEELLAEAGvreRILGIGIGVPGPVDPETGIV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 166 HYMPHIQ-VENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGE 244
Cdd:cd23763   78 LFAPNLPwWKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYITLGTGIGGGIIIDGKLYRGANGAAGE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 245 IGHIQveplgerchcgnfgcletiaanaaieqrvlnllkqgyqsrvplddctiktickaankgdslaseVIEYVGRHLGK 324
Cdd:cd23763  158 IGHIT----------------------------------------------------------------VLEEAARYLGI 173

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985003816 325 TIAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRS-AIGAFAL 389
Cdd:cd23763  174 GLANLINLLNPELIVLGGGVAEAGDLLLEPIREAVRRRALPPLRRRVRIVPSELGDDAgLLGAAAL 239
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 127-389 3.77e-50

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 170.82  E-value: 3.77e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 127 HALLNAIAQFIDSYQRKLR-ELIAISviLPGLVDPDSGKIHYM-PHIQveNW-G--LVEALEERFKVTCFVGHDIRSLAL 201
Cdd:cd24068   38 DAILERLLEIIAELKEKYDiEGIGIS--SAGQVDPKTGEVIYAtDNLP--GWtGtnLKEELEERFGLPVAVENDVNCAAL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 202 AEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIGHIQVEPLGERCHCGNFGCLETIAANAAIEQRvlnl 281
Cdd:cd24068  114 AEKWLGAAKGLDDFLCLTLGTGIGGAIILDGRLYRGANGSAGELGHMVVDPGGRPCCCGGKGCLEQYASGTALVRR---- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 282 lkqgYQSRVPLDDCTIKTICKAANKGDSLASEVIEYVGRHLGKTIAIAINLFNPQKIVIAGEITEADKVLLPAIESCINT 361
Cdd:cd24068  190 ----VAEALGEPGIDGREIFDLADAGDPLAKEVVEEFAEDLATGLANLVHIFDPEVIVIGGGISAQGELFLEELREELRK 265

                        250       260
                 ....*....|....*....|....*....
gi 985003816 362 QALKAFRTNLPVVRSELDHRSA-IGAFAL 389
Cdd:cd24068  266 LLMPPLLDATKIEPAKLGNDAGlLGAAYL 294
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 87-360 1.15e-47

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 164.90  E-value: 1.15e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  87 HAIGVRLGRHDATITLFDLSSKVLAEEhyplpERTQQTLEH--ALLNAIAQFIDSY-QRKLRELIAISVILPGLVDPDSG 163
Cdd:cd24072    2 WVLGIVVSPNSLRAQVGNACGELLGEF-----EYRVITLETpeALIDEIIDCIDRLlKLWKDRVKGIALAIQGLVDSHKG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 164 KIHYMPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVG 243
Cdd:cd24072   77 VSLWSPGAPWRNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVINLDYGIGSAIVIDNKLYIGASSGSG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 244 EIGHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDcTIKTICKAANKGDSLASEVIEYVGRHLG 323
Cdd:cd24072  157 EIGHTKVNPDGARCDCGRRGCLETVASNSALKRNARVTLKLGPVSADPEKL-TMEQLIEALEEGEPIATQIFDRAANAIG 235

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 985003816 324 KTIAIAINLFNPQKIVIAGEITEADKVLLPAIESCIN 360
Cdd:cd24072  236 RSLANILNLLNPEQVLLYGRGCRAGDLLLPAIRRAIA 272
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 87-390 8.39e-46

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 159.63  E-value: 8.39e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  87 HAIGVRLGRHDATITLFDLSSKVLAEEHYPLPERTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDsgKIH 166
Cdd:cd24077    2 YSIGIDLGYNYISLMLTYLDGEIISSKQIKLLDISFENILEILKSIIQELISQAPKTPYGLVGIGIGIHGIVDEN--EII 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 167 YMPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFgaSQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIG 246
Cdd:cd24077   80 FTPYYDLEDIDLKEKLEEKFNVPVYLENEANLSALAERTF--SEDYDNLISISIHSGIGAGIIINNQLYRGYNGFAGEIG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 247 HIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKqgyqsrvpLDDCTIKTICKAANKGDSLASEVIEYVGRHLGKTI 326
Cdd:cd24077  158 HMIIVPNGKPCPCGNKGCLEQYASEKALLKELSEKKG--------LETLTFDDLIQLYNEGDPEALELIDQFIKYLAIGI 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 985003816 327 AIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQalkaFRTNLPVVRSEL-DHRSAIGAFALV 390
Cdd:cd24077  230 NNIINTFNPEIIIINSSLINEIPELLEKIKEQLSSS----FNKYVEILISTLgKNATLLGGAAVA 290
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 132-378 7.81e-45

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 157.45  E-value: 7.81e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 132 AIAQFIDSYQRKLRELIAISVILPGLVDPDSGKIHYMPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQD 211
Cdd:cd24062   47 SIQQLLEELGYSKEDLIGIGVGVPGPVDVETGTVEVAVNLGWKNFPLKDKLEALTGIPVVIDNDANAAALGEMWKGAGQG 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 212 CEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIGHIQVEP-LGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRV 290
Cdd:cd24062  127 AKDLVFITLGTGVGGGVIANGKIVHGANGAAGEIGHITVNPeGGAPCNCGKTGCLETVASATGIVRIAREELEEGKGSSA 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 291 PL-----DDCTIKTICKAANKGDSLASEVIEYVGRHLGKTIAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALK 365
Cdd:cd24062  207 LRilalgGELTAKDVFEAAKAGDELALAVVDTVARYLGLALANLANTLNPEKIVIGGGVSAAGEFLLSPVKEYFDRFTFP 286

                        250
                 ....*....|...
gi 985003816 366 AFRTNLPVVRSEL 378
Cdd:cd24062  287 RVRQDTEIVLATL 299
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 88-384 6.30e-42

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 149.57  E-value: 6.30e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  88 AIGVRLGRHDATITLFDLSSKVLAEEhyPLPERTQQTLEhALLNAIAQFIDSYQRKLrELIAISVILPGLVDPDSGKIHY 167
Cdd:cd24064    1 VIGIDLGGTDTKIGIVDENGDILKKK--TIDTKVENGKE-DVINRIAETVNELIEEM-ELLGIGIGSPGSIDRENGIVRF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 168 MPHI-QVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIG 246
Cdd:cd24064   77 SPNFpDWRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGLTLGTGVGSGVICHGQLLTGYDGIAAELG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 247 HIQVEPLGERCHCGNFGCLETIAANAAIeQRVLNLLKQGYQSRVP--LDDCTIKTICKAANKGDSLASEVIEYVGRHLGK 324
Cdd:cd24064  157 HVIVEPNGPICGCGNRGCVEAFASATAI-IRYARESRKRYPDSLAgeSEKINAKHVFDAARKNDPLATMVFRRVVDALAI 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 325 TIAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRSAI 384
Cdd:cd24064  236 AIGGFVHIFNPEIIIIGGGISRAGSFLLDPIREKTKKYVMLSFQDTYSIELSNLVEDAGI 295
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 88-372 2.17e-41

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 148.27  E-value: 2.17e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  88 AIGVRLGRHDATITLFDLSSKVLAEEHYPLPeRTQQTLEHALLNAIAQFIDSYqrklrELIAISVILPGLVDPDSGKIHY 167
Cdd:cd24061    1 TIGVDIGGTKIAAGVVDEEGEILATERVPTP-PTADGIVDAIVEAVEELREGH-----DVSAVGVAAAGFVDADRATVLF 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 168 MPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIGH 247
Cdd:cd24061   75 APNIAWRNEPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVMITVGTGLGGGIVIGGKLLRGAFGIAGEFGH 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 248 IQVEPLGERCHCGNFGCLETIAANAAIeQR--VLNLLKQGYQSRVPLDDCTI-----KTICKAANKGDSLASEVIEYVGR 320
Cdd:cd24061  155 IRVVPDGLLCGCGSRGCWEQYASGRAL-VRyaKEAANATPEGAAVLLADGSVdgitgKHISEAARAGDPVALDALRELAR 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 985003816 321 HLGKTIAIAINLFNPQKIVIAGEITEADKVLLPAIEscintqalKAFRTNLP 372
Cdd:cd24061  234 WLGAGLASLAALLDPELFVIGGGVSDAGDLLLDPIR--------EAFERWLP 277
ROK_glcA_fam TIGR00744
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ...
 89-395 5.89e-39

ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]


Pssm-ID: 273246 [Multi-domain]  Cd Length: 318  Bit Score: 141.96  E-value: 5.89e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816   89 IGVRLGRHDATITLFDLSSKVLAEEHYPLPeRTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKIHYM 168
Cdd:TIGR00744   1 IGVDIGGTTIKLGVVDEEGNILSKWKVPTD-TTPETIVDAIASAVDSFIQHIAKVGHEIVAIGIGAPGPVNRQRGTVYFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  169 PHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIGHI 248
Cdd:TIGR00744  80 VNLDWKQEPLKEKVEARVGLPVVVENDANAAALGEYKKGAGKGARDVICITLGTGLGGGIIINGEIRHGHNGVGAEIGHI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  249 QVEPLGE-RCHCGNFGCLETIAANAAIeqrvLNLLKQGY------QSRVPL---DDCTIKTICKAANKGDSLASEVIEYV 318
Cdd:TIGR00744 160 RMVPDGRlLCNCGKQGCIETYASATGL----VRYAKRANakperaEVLLALgdgDGISAKHVFVAARQGDPVAVDSYREV 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 985003816  319 GRHLGKTIAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRSAI-GAFALVKRAML 395
Cdd:TIGR00744 236 ARWAGAGLADLASLFNPSAIVLGGGLSDAGDLLLDPIRKSYKRWLFGGARQVADIIAAQLGNDAGLvGAADLARTYII 313
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 89-357 1.25e-38

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 140.54  E-value: 1.25e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  89 IGVRLGRHDATITLFDlSSKVLAEEHYPLPertqQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKIHYM 168
Cdd:cd24065    3 IGLDLGGTKIAAGVVD-GGRILSRLVVPTP----REGGEAVLDALARAVEALQAEAPGVEAVGLGVPGPLDFRRGRVRFA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 169 PHIQ-VENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIGH 247
Cdd:cd24065   78 PNIPgLTDFPIRRGLAERLGLPVVLENDANAAALAEHHYGAARGTESSVYVTISTGIGGGLVLGGRVLRGRHGQAGEIGH 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 248 IQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQgyqsrvpldDCTIKTICKAANKGDSLASEVIEYVGRHLGKTIA 327
Cdd:cd24065  158 TTVLPGGPMCGCGLVGCLEALASGRALARDASFAYGR---------PMSTAELFELAQQGEPKALRIVEQAAAHLGIGLA 228

                        250       260       270
                 ....*....|....*....|....*....|.
gi 985003816 328 IAINLFNPQKIVIAGEI-TEADKVLLPAIES 357
Cdd:cd24065  229 NLQKALDPEVFVLGGGVaQVGDYYLLPVQEA 259
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 88-389 1.49e-38

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 140.55  E-value: 1.49e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  88 AIGVRLGRHDATITLFDLSSKVLAEEHYPLPERTQQ-TLEHALLNAIAQFIDSYQRKLRELIAISVILPglVDPDSGKIH 166
Cdd:cd24063    2 YVAVDIGGTWIRAGLVDEDGRILLKIRQPTPKTGDPgTVSEQVLGLIETLLSKAGKDSIEGIGVSSAGP--LDLRKGTIV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 167 YMPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIG 246
Cdd:cd24063   80 NSPNIKGKEIPLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTGIGGGVIVDGRLLLGKNGNAAEVG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 247 HIQVEP-LGERCHCGNFGCLETIAANAAIEQRVLNLLKQG------YQSRVPLDDCTIKTICKAANKGDSLASEVIEYVG 319
Cdd:cd24063  160 HLVVDTeSGLKCGCGGYGHWEAFASGRGIPRFAREWAEGFssrtslKLRNPGGEGITAKEVFSAARKGDPLALKIIEKLA 239

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985003816 320 RHLGKTIAIAINLFNPQKIVIAGEITEADKVLL-PAIEscintQALKAFRTNLP--VVRSELDHRSA-IGAFAL 389
Cdd:cd24063  240 RYNGRGIANVINAYDPELIVIGGSVFNNNKDILdPLIE-----YLEKNPAISKGpeIVLSELGDDVGlIGALAL 308
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 127-391 8.45e-34

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 127.67  E-value: 8.45e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 127 HALLNAIAQFIDSYQRKLR-ELIAISVILPGLVDPDSGKIHYMPHIQV-ENWGLVEALEERFKVTCFVGHDIRSLALAEH 204
Cdd:cd24070   39 GDPVEVLADLIREYIEEAGlKPAAIVIGVPGTVDKDRRTVISTPNIPGlDGVNLADILENKLGIPVILERDVNLLLLYDM 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 205 YFGASQDceDSILVRVHRGTGAG--IISNGRIFIGRNGNVGEIGHIQVEPLGERCHCGNFGCLETIAANAAIEQrvlnLL 282
Cdd:cd24070  119 RAGNLDD--EGVVLGFYIGTGIGnaILINGKPLRGKNGVAGELGHIPVYGNGKPCGCGNTGCLETYASGRALEE----IA 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 283 KQGYqsrvplddctIKTICKAANKGDSLASEVIEYVgRHLGKTIAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQ 362
Cdd:cd24070  193 EEHY----------PDTPILDIFVDHGDEPELDEFV-EDLALAIATEINILDPDAVILGGGVIDMKGFPRETLEEYIRKH 261

                        250       260       270
                 ....*....|....*....|....*....|.
gi 985003816 363 ALKAF-RTNLPVVRSELDHRSA-IGAFALVK 391
Cdd:cd24070  262 LRKPYpADNLKIIYAELGPEAGvIGAAIYAF 292
PRK09698 PRK09698
D-allose kinase; Provisional
 119-396 5.91e-29

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 114.69  E-value: 5.91e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 119 ERTQQTLEHALLNAIAQFIDSY-QRKLRELIAISVILPGLVDPDSGKIHYMPHIQV---ENWGLVEALEERFKVTCFVGH 194
Cdd:PRK09698  33 KRTAEVIAPDLVSGLGEMIDEYlRRFNARCHGIVMGFPALVSKDRRTVISTPNLPLtalDLYDLADKLENTLNCPVFFSR 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 195 DIRSLAL--AEHYfgasqDCEDSILVRVHRGTGAG--IISNGRIFIGRNGNVGEIGHIQVEPLGERCHCGNFGCLETIAA 270
Cdd:PRK09698 113 DVNLQLLwdVKEN-----NLTQQLVLGAYLGTGMGfaVWMNGAPWTGAHGVAGELGHIPLGDMTQHCGCGNPGCLETNCS 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 271 NAAieqrvlnlLKQGYQSR---VPLDDCTIKTickaankGDSLAsevIEYVGRHLGKTIAIAINLFNPQKIVIAGEITEA 347
Cdd:PRK09698 188 GMA--------LRRWYEQQprdYPLSDLFVHA-------GDHPF---IQSLLENLARAIATSINLFDPDAIILGGGVMDM 249

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 985003816 348 DKVLLPAIESCINTQALKAF-RTNLPVVRSEL-DHRSAIGAFALVKRAMLN 396
Cdd:PRK09698 250 PAFPRETLIAMIQKYLRKPLpYEVVRFIYASSsDFNGAQGAAILAHQRFLP 300
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 102-351 3.21e-23

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 98.41  E-value: 3.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 102 LFDLSSKVLAEEHYPlperTQQTLEHALLNAIAQFIDSYQRKLrELIAISVilPGLVDPDSGKIH---YMPHIQVENWgl 178
Cdd:cd24152   16 LVDENGNIIKKGKIP----TPKDSLEEFLDYIKKIIKRYDEEI-DGIAISA--PGVIDPETGIIYgggALPYLKGFNL-- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 179 VEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIGHIQveplgercH 258
Cdd:cd24152   87 KEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFFAGEFSYLL--------T 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 259 CGNFGCLETIAANAAieqrVLNLLKqGYQSRVPLDDCTIKTICKAANKGDSLASEVI-EYVGRhLGKTIAIAINLFNPQK 337
Cdd:cd24152  159 DDDDKDLLFFSGLAS----MFGLVK-RYNKAKGLEPLDGEEIFEKYAKGDEAAKKILdEYIRN-LAKLIYNIQYILDPEV 232

                        250
                 ....*....|....
gi 985003816 338 IVIAGEITEADKVL 351
Cdd:cd24152  233 IVIGGGISEQPLFI 246
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 88-389 8.14e-21

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 92.09  E-value: 8.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  88 AIGVRLGRHDATITLFDLSSKVLAEEHYPLPE--RTQQTLEHALLNAIAQfiDSYQRKLReLIAISVILPGLVDPDSGKI 165
Cdd:cd24060    2 ALAVDLGGTNLRVAIVSMKGEIVKKYTQPNPKtyEERIDLILQMCVEAAS--EAVKLNCR-ILGVGISTGGRVNPREGIV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 166 HYMPHIqVENWGLVE---ALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNV 242
Cdd:cd24060   79 LHSTKL-IQEWSSVDlrtPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITGTGIGGGIILNHELIHGSSFCA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 243 GEIGHIQVEPLGERCHCGNFGCLETIAANAAI--EQRVLN----LLKQGyQSRVPLDDCTIKTICKAANKGDSLASEVIE 316
Cdd:cd24060  158 AELGHIVVSLDGPDCMCGSHGCVEAYASGMALqrEAKKLHdedlLLVEG-MSVTNDEEVTAKHLIQAAKLGNAKAQKILR 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 985003816 317 YVGRHLGKTIAIAINLFNPQKIVIAGeiteadkVLLPAIES----CINTQALKAFRtNLPVVRSELDHRSAIGAFAL 389
Cdd:cd24060  237 TAGTALGLGIVNILHTLNPSLVILSG-------VLASHYENivkdVIAQRALPSVQ-NVDVVVSDLVDPALLGAASM 305
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 128-342 4.30e-20

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 89.60  E-value: 4.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 128 ALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKIHY--MPHIQveNWGLVEALEERFKVTCFVGHDIRSLALAEHY 205
Cdd:cd24057   38 AFLAAIAELVAEADARFGVKGPVGIGIPGVIDPEDGTLITanIPAAK--GRPLRADLSARLGRPVRIDNDANCFALSEAW 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 206 FGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIGH----IQVEPLGE-----RCHCGNFGCLETIAANAAIEQ 276
Cdd:cd24057  116 DGAGRGYPSVFGLILGTGVGGGLVVNGRLVGGRSGIAGEWGHgplpADALLLGYdlpvlRCGCGQTGCLETYLSGRGLER 195

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985003816 277 RVLNLLKQGYQSRvplddctikTICKAANKGDSLASEVIEYVGRHLGKTIAIAINLFNPQKIVIAG 342
Cdd:cd24057  196 LYAHLYGEELDAP---------EIIAAWAAGDPQAVAHVDRWLDLLAGCLANILTALDPDVVVLGG 252
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 178-348 2.87e-19

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 86.95  E-value: 2.87e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 178 LVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIGHIQVEPLGERC 257
Cdd:cd24069   84 LADALQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNLVFITVSTGVGGGLVLNGQLLTGPNGLAGHIGHTLADPPGPVC 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 258 HCGNFGCLETIAANAAIEQRVLNLLKQGyqsrvplddCTIKTICKAANKGDSLASEVIEYVGRHLGKTIAIAINLFNPQK 337
Cdd:cd24069  164 GCGRRGCVEAIASGTAIAAAASEILGEP---------VDAKDVFERARSGDEEAARLIDRAARALADLIADLKATLDLDC 234

                        170
                 ....*....|.
gi 985003816 338 IVIAGEITEAD 348
Cdd:cd24069  235 VVIGGSVGLAE 245
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 178-348 1.61e-16

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 79.19  E-value: 1.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 178 LVEALEERFKVTCFVGHDIRSLALAEhYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIGHIQVEPLGERC 257
Cdd:PRK05082  88 LVQTLEQLTDLPTIALNDAQAAAWAE-YQALPDDIRNMVFITVSTGVGGGIVLNGKLLTGPGGLAGHIGHTLADPHGPVC 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 258 HCGNFGCLETIAANAAIEQrvlnllkqgyQSRVPLDDCTIKTICKAANKGDSLASEVIEYVGRHLGKTIA-IAINLfNPQ 336
Cdd:PRK05082 167 GCGRRGCVEAIASGRAIAA----------AAQGWLAGCDAKTIFERAGQGDEQAQALINRSAQAIARLIAdLKATL-DCQ 235

                        170
                 ....*....|..
gi 985003816 337 KIVIAGEITEAD 348
Cdd:PRK05082 236 CVVLGGSVGLAE 247
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 112-342 4.94e-16

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 78.01  E-value: 4.94e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 112 EEHYPLPERTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKI-----HYM---PhiqvenwgLVEALE 183
Cdd:cd24066   21 RELLRRRVPTPRGDYEATLDAIADLVEEAEEELGAPATVGIGTPGSISPRTGLVknansTWLngkP--------LKADLE 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 184 ERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIGHIQVEPL------GERC 257
Cdd:cd24066   93 ARLGRPVRIENDANCFALSEATDGAGAGAGVVFGVILGTGVGGGIVVNGRVLTGANGIAGEWGHNPLPWPdedelpGPPC 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 258 HCGNFGCLETIAANAAIEQRvlnlLKQGYQSRVPLDDctiktICKAANKGDSLASEVIEYVGRHLGKTIAIAINLFNPQK 337
Cdd:cd24066  173 YCGKRGCVETFLSGPALERD----YARLTGKTLSAEE-----IVALARAGDAAAVATLDRFLDRLGRALANVINILDPDV 243


                 ....*
gi 985003816 338 IVIAG 342
Cdd:cd24066  244 IVLGG 248
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 118-389 9.98e-13

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 67.95  E-value: 9.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 118 PERTqqtlehalLNAIAQFIDSYQRKLRElIAISVILPGLVDPDSGKIHYMPHIQVENWG---LVEALEERFKVTCFVGH 194
Cdd:cd24067   33 PEET--------LQAVIDFFREQEEPIDA-IGIASFGPIDLNPTSPTYGYITTTPKPGWRnfdILGALKRAFPVPVGFDT 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 195 DIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNvgEIGHIQVEPLGERCH----C---GNfgCLET 267
Cdd:cd24067  104 DVNAAALAEYRWGAAKGLDSLAYITVGTGIGVGLVVNGKPVHGLLHP--EMGHIRVPRHPDDDGfpgvCpfhGD--CLEG 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 268 IAANAAIEQRVLNLLKQgyqsrVPLDDctiktickaankgdslasEVIEYVGRHLGKTIAIAINLFNPQKIVIAGEITEA 347
Cdd:cd24067  180 LASGPAIAARWGIPAEE-----LPDDH------------------PAWDLEAYYLAQACANLTLTLSPERIVLGGGVMQR 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 985003816 348 dKVLLPAIESciNTQAL-------KAFRTNLP--VVRSELDHRSAI-GAFAL 389
Cdd:cd24067  237 -PGLFPRIRE--KFRKLlngylevPRLLPDIDeyIVPPALGNDAGIlGALAL 285
PRK13310 PRK13310
N-acetyl-D-glucosamine kinase; Provisional
 103-354 1.16e-12

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 183967 [Multi-domain]  Cd Length: 303  Bit Score: 68.09  E-value: 1.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 103 FDLSSKVLAEEHYPlperTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGkIHYMPHIQV-ENWGLVEA 181
Cdd:PRK13310  17 FNEKLELQWEERVP----TPRDSYDAFLDAVCELVAEADQRFGCKGSVGIGIPGMPETEDG-TLYAANVPAaSGKPLRAD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 182 LEERFKVTCFVGHDIRSLALAEHYFGASQDcEDSIL-VRVHRGTGAGIISNGRIFIGRNGNVGEIGHIQV-----EPLGE 255
Cdd:PRK13310  92 LSARLGRDVRLDNDANCFALSEAWDDEFTQ-YPLVMgLILGTGVGGGLVFNGKPISGRSYITGEFGHMRLpvdalTLLGW 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 256 -----RCHCGNFGCLETIaanaaIEQRVLNLLKQGYQSRvPLDdctIKTICKAANKGDSLAsevIEYVGRHLgKTIAIAI 330
Cdd:PRK13310 171 daplrRCGCGQKGCIENY-----LSGRGFEWLYQHYYGE-PLQ---APEIIALYYQGDEQA---VAHVERYL-DLLAICL 237

                        250       260       270
                 ....*....|....*....|....*....|....
gi 985003816 331 -NLF---NPQKIVIAG------EITEADKVLLPA 354
Cdd:PRK13310 238 gNILtivDPHLVVLGGglsnfdAIYEQLPKRLPR 271
PRK09557 PRK09557
fructokinase; Reviewed
 89-355 1.55e-12

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 67.74  E-value: 1.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816  89 IGVRLGRHDATITLFDLSSKVLAEEHYPLPERT-QQTLEhallnAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKIHY 167
Cdd:PRK09557   3 IGIDLGGTKIEVIALDDAGEELFRKRLPTPRDDyQQTIE-----AIATLVDMAEQATGQRGTVGVGIPGSISPYTGLVKN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 168 MPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIGH 247
Cdd:PRK09557  78 ANSTWLNGQPLDKDLSARLNREVRLANDANCLAVSEAVDGAAAGKQTVFAVIIGTGCGAGVAINGRVHIGGNGIAGEWGH 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 248 iqvEPL------------GERCHCGNFGCLETIAANAAieqrvlnlLKQGYQ--SRVPLDDCTIKTICKAankGDSLASE 313
Cdd:PRK09557 158 ---NPLpwmdedelryrnEVPCYCGKQGCIETFISGTG--------FATDYRrlSGKALKGSEIIRLVEE---GDPVAEL 223

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 985003816 314 VIEYVGRHLGKTIAIAINLFNPQKIVIAGEITEADKV--LLPAI 355
Cdd:PRK09557 224 AFRRYEDRLAKSLAHVINILDPDVIVLGGGMSNVDRLypTLPAL 267
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 25-77 1.81e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 42.15  E-value: 1.81e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 985003816   25 RLIDQYGPISRIQIAEQSQLAPASVTKITRQLIERGLIkevDQQASTGGRRAI 77
Cdd:pfam01047  10 RILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLI---ERSRSPEDRREV 59
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
25-79 2.94e-05

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 42.58  E-value: 2.94e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 985003816    25 RLIDQYGPISRIQIAEQSQLAPASVTKITRQLIERGLIkevDQQASTGGRRAISI 79
Cdd:smart00347  17 RILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLV---RREPSPEDRRSVLV 68
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
22-63 9.60e-05

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 42.11  E-value: 9.60e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 985003816  22 AVYRLIDQYGPISRIQIAEQSQLAPASVTKITRQLIERGLIK 63
Cdd:COG1321   14 AIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVE 55
PRK13311 PRK13311
N-acetyl-D-glucosamine kinase; Provisional
 149-294 1.94e-04

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 106271 [Multi-domain]  Cd Length: 256  Bit Score: 42.71  E-value: 1.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985003816 149 AISVILPGLVDPDSGKIHYMPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGI 228
Cdd:PRK13311  59 SVGIGIPGLPNADDGTVFTANVPSAMGQPLQADLSRLIQREVRIDNDANCFALSEAWDPEFRTYPTVLGLILGTGVGGGL 138

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985003816 229 ISNGRIFIGRNGNVGEIGHIQ-----VEPLGER-----CHCGNFGCLETIAANAAIEQrvlnLLKQGYQSRVPLDD 294
Cdd:PRK13311 139 IVNGSIVSGRNHITGEFGHFRlpvdaLDILGADiprvpCGCGHRGCIENYISGRGFEW----MYSHFYQHTLPATD 210
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 22-63 2.26e-03

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 36.20  E-value: 2.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 985003816   22 AVYRLIDQYGPISRIQIAEQSQLAPASVTKITRQLIERGLIK 63
Cdd:pfam01325   9 TIYTLSEEKGVVKTKDLAERLNVSPSTVSEMLKKLEKMGYVD 50
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
25-80 6.00e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 36.87  E-value: 6.00e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 985003816  25 RLIDQYGPISRIQIAEQSQLAPASVTKITRQLIERGLIKevdQQASTGGRRAISIV 80
Cdd:COG1846   45 AALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE---REPDPEDRRAVLVR 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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