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Conserved domains on  [gi|999848871|gb|AML00243|]
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methyltransferase [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

adenine-specific DNA-methyltransferase( domain architecture ID 10013823)

adenine-specific DNA-methyltransferase similar to Escherichia coli DNA adenine methyltransferase YhdJ that methylates the second adenine of the NsiI recognition sequence (5'-ATGCAT-3')

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11524 PRK11524
adenine-specific DNA-methyltransferase;
7-290 0e+00

adenine-specific DNA-methyltransferase;


:

Pssm-ID: 183177 [Multi-domain]  Cd Length: 284  Bit Score: 591.31  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871   7 PTRFGNEAKTIIHGDALAELKKIPAESVDLIFADPPYNIGKNFDGLIEAWKEDLFIDWLFEVIAECHRVLKKQGSMYIMN 86
Cdd:PRK11524   1 PTRFGNEAKTIIHGDALTELKKIPSESVDLIFADPPYNIGKNFDGLIEAWKEDLFIDWLYEWIDECHRVLKKQGTMYIMN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871  87 STENMPFIDLQCRKLFTIKSRIVWSYDSSGVQAKKHYGSMYEPILMMVKDAKNYTFNGDAILVEAKTGSQRALIDYRKNP 166
Cdd:PRK11524  81 STENMPFIDLYCRKLFTIKSRIVWSYDSSGVQAKKYFGSMYEPILMMVKDAKNYTFNGDAILVEAKTGAKRALIDYRKNP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871 167 PQPYNHQKVPGNVWDFPRVRYLMDEYENHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAIASGRKFIGIEINS 246
Cdd:PRK11524 161 PQPYNTQKVPGNVWDFPRVRYLMDEYENHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAKASGRKFIGIEINS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 999848871 247 EYIKMGLRRLDVASHYSAEELAKVKKRKTGNLSKRSRLSEVDPD 290
Cdd:PRK11524 241 EYIKMGLRRLDVASHYSAEELAKVKKRKTGNLSKKSRLSEVDPD 284
 
Name Accession Description Interval E-value
PRK11524 PRK11524
adenine-specific DNA-methyltransferase;
7-290 0e+00

adenine-specific DNA-methyltransferase;


Pssm-ID: 183177 [Multi-domain]  Cd Length: 284  Bit Score: 591.31  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871   7 PTRFGNEAKTIIHGDALAELKKIPAESVDLIFADPPYNIGKNFDGLIEAWKEDLFIDWLFEVIAECHRVLKKQGSMYIMN 86
Cdd:PRK11524   1 PTRFGNEAKTIIHGDALTELKKIPSESVDLIFADPPYNIGKNFDGLIEAWKEDLFIDWLYEWIDECHRVLKKQGTMYIMN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871  87 STENMPFIDLQCRKLFTIKSRIVWSYDSSGVQAKKHYGSMYEPILMMVKDAKNYTFNGDAILVEAKTGSQRALIDYRKNP 166
Cdd:PRK11524  81 STENMPFIDLYCRKLFTIKSRIVWSYDSSGVQAKKYFGSMYEPILMMVKDAKNYTFNGDAILVEAKTGAKRALIDYRKNP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871 167 PQPYNHQKVPGNVWDFPRVRYLMDEYENHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAIASGRKFIGIEINS 246
Cdd:PRK11524 161 PQPYNTQKVPGNVWDFPRVRYLMDEYENHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAKASGRKFIGIEINS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 999848871 247 EYIKMGLRRLDVASHYSAEELAKVKKRKTGNLSKRSRLSEVDPD 290
Cdd:PRK11524 241 EYIKMGLRRLDVASHYSAEELAKVKKRKTGNLSKKSRLSEVDPD 284
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
16-268 9.02e-90

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 266.79  E-value: 9.02e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871  16 TIIHGDALAELKKIPAESVDLIFADPPYNIGKNFD---GLIEAWKE-DLFIDWLFEVIAECHRVLKKQGSMYIMNSTENM 91
Cdd:COG0863    1 RLICGDCLEVLKELPDESVDLIVTDPPYNLGKKYGlgrREIGNELSfEEYLEFLREWLAECYRVLKPGGSLYVNIGDRYI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871  92 PFIDLQCRKL-FTIKSRIVWSYDS-SGVQAKKHYGSMYEPILMMVKDaKNYTFNGDAIlveaktgsqralidyrknppQP 169
Cdd:COG0863   81 SRLIAALRDAgFKLRNEIIWRKPNgVPGPSKRRFRNSHEYILWFTKG-KKYTFNVDAV--------------------KS 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871 170 YNHQKVPGNVWDFPRVRylMDEYENHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAIASGRKFIGIEINSEYI 249
Cdd:COG0863  140 IEDGRNPSDVWDIPGVT--PKERKGHPTQKPVELLERLILASSNPGDIVLDPFAGSGTTLVAAERLGRRFIGIEIDPEYV 217

                        250
                 ....*....|....*....
gi 999848871 250 KMGLRRLDVASHYSAEELA 268
Cdd:COG0863  218 EVARRRLEEATGLEFEELA 236
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 34-251 1.11e-74

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 228.05  E-value: 1.11e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871   34 VDLIFADPPYNIGKNFDGLIEAWKEDLFIDWLFEVIAECHRVLKKQGSMYIMNSTENMPFIDLQCR---KLFTIKSRIVW 110
Cdd:pfam01555   1 VDLIVTDPPYNLGKDYGQWDDKDSIEEYLEWLEEWLKEVRRVLKPGGSIFINIGDSNIKSLKALALeilGIFKLLNDIIW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871  111 SYDSS-GVQAKKHYGSMYEPILMMVKDAKNYTFNGDAILVEAKTGSQRALIDYRKNPpqpynhqKVPGNVWDFPRVRYLM 189
Cdd:pfam01555  81 RKPNGmPNSNGERFTPAHEYILWFSKTKKYKTFNYDAIKVPYDEKDKLKKRGSEPNG-------KPIGDVWDFSRVQPSE 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 999848871  190 DEYEN---HPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAIASGRKFIGIEINSEYIKM 251
Cdd:pfam01555 154 KESGGngkHPTQKPEALLERLILASTNPGDIVLDPFAGSGTTGAAAKELGRNFIGIEIEEEYVEI 218
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 16-85 1.83e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 40.11  E-value: 1.83e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871  16 TIIHGDALaELKKIPAESVDLIFADPPYnigknfdgliEAWKEDlfidwLFEVIAECHRVLKKQGSMYIM 85
Cdd:cd02440   50 EVLKGDAE-ELPPEADESFDVIISDPPL----------HHLVED-----LARFLEEARRLLKPGGVLVLT 103
 
Name Accession Description Interval E-value
PRK11524 PRK11524
adenine-specific DNA-methyltransferase;
7-290 0e+00

adenine-specific DNA-methyltransferase;


Pssm-ID: 183177 [Multi-domain]  Cd Length: 284  Bit Score: 591.31  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871   7 PTRFGNEAKTIIHGDALAELKKIPAESVDLIFADPPYNIGKNFDGLIEAWKEDLFIDWLFEVIAECHRVLKKQGSMYIMN 86
Cdd:PRK11524   1 PTRFGNEAKTIIHGDALTELKKIPSESVDLIFADPPYNIGKNFDGLIEAWKEDLFIDWLYEWIDECHRVLKKQGTMYIMN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871  87 STENMPFIDLQCRKLFTIKSRIVWSYDSSGVQAKKHYGSMYEPILMMVKDAKNYTFNGDAILVEAKTGSQRALIDYRKNP 166
Cdd:PRK11524  81 STENMPFIDLYCRKLFTIKSRIVWSYDSSGVQAKKYFGSMYEPILMMVKDAKNYTFNGDAILVEAKTGAKRALIDYRKNP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871 167 PQPYNHQKVPGNVWDFPRVRYLMDEYENHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAIASGRKFIGIEINS 246
Cdd:PRK11524 161 PQPYNTQKVPGNVWDFPRVRYLMDEYENHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAKASGRKFIGIEINS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 999848871 247 EYIKMGLRRLDVASHYSAEELAKVKKRKTGNLSKRSRLSEVDPD 290
Cdd:PRK11524 241 EYIKMGLRRLDVASHYSAEELAKVKKRKTGNLSKKSRLSEVDPD 284
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
16-268 9.02e-90

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 266.79  E-value: 9.02e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871  16 TIIHGDALAELKKIPAESVDLIFADPPYNIGKNFD---GLIEAWKE-DLFIDWLFEVIAECHRVLKKQGSMYIMNSTENM 91
Cdd:COG0863    1 RLICGDCLEVLKELPDESVDLIVTDPPYNLGKKYGlgrREIGNELSfEEYLEFLREWLAECYRVLKPGGSLYVNIGDRYI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871  92 PFIDLQCRKL-FTIKSRIVWSYDS-SGVQAKKHYGSMYEPILMMVKDaKNYTFNGDAIlveaktgsqralidyrknppQP 169
Cdd:COG0863   81 SRLIAALRDAgFKLRNEIIWRKPNgVPGPSKRRFRNSHEYILWFTKG-KKYTFNVDAV--------------------KS 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871 170 YNHQKVPGNVWDFPRVRylMDEYENHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAIASGRKFIGIEINSEYI 249
Cdd:COG0863  140 IEDGRNPSDVWDIPGVT--PKERKGHPTQKPVELLERLILASSNPGDIVLDPFAGSGTTLVAAERLGRRFIGIEIDPEYV 217

                        250
                 ....*....|....*....
gi 999848871 250 KMGLRRLDVASHYSAEELA 268
Cdd:COG0863  218 EVARRRLEEATGLEFEELA 236
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 34-251 1.11e-74

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 228.05  E-value: 1.11e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871   34 VDLIFADPPYNIGKNFDGLIEAWKEDLFIDWLFEVIAECHRVLKKQGSMYIMNSTENMPFIDLQCR---KLFTIKSRIVW 110
Cdd:pfam01555   1 VDLIVTDPPYNLGKDYGQWDDKDSIEEYLEWLEEWLKEVRRVLKPGGSIFINIGDSNIKSLKALALeilGIFKLLNDIIW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871  111 SYDSS-GVQAKKHYGSMYEPILMMVKDAKNYTFNGDAILVEAKTGSQRALIDYRKNPpqpynhqKVPGNVWDFPRVRYLM 189
Cdd:pfam01555  81 RKPNGmPNSNGERFTPAHEYILWFSKTKKYKTFNYDAIKVPYDEKDKLKKRGSEPNG-------KPIGDVWDFSRVQPSE 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 999848871  190 DEYEN---HPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAIASGRKFIGIEINSEYIKM 251
Cdd:pfam01555 154 KESGGngkHPTQKPEALLERLILASTNPGDIVLDPFAGSGTTGAAAKELGRNFIGIEIEEEYVEI 218
Mod COG2189
Adenine specific DNA methylase Mod [Replication, recombination and repair];
17-256 2.36e-28

Adenine specific DNA methylase Mod [Replication, recombination and repair];


Pssm-ID: 441792 [Multi-domain]  Cd Length: 491  Bit Score: 113.33  E-value: 2.36e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871  17 IIHGD---ALAELKKIPAESVDLIFADPPYNIGKNF----DGLIEAWKEDLFIDWL------FEVIaecHRVLKKQGSMY 83
Cdd:COG2189   39 LIEGDnleALKLLQESYAGKVKCIYIDPPYNTGNDFfaynDNFETESNGRFHSSWLsmmyprLKLA---RELLSEDGVIF 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871  84 IMNSTENMPFIDLQCRKLFTIKSR---IVWSYDSSGVQAKKHYGSMYEPILMMVKDAKNYTFNGdaILVEAKTGSQRALI 160
Cdd:COG2189  116 VSIDDNEVHYLKLLLDEIFGEENFvatIIWKKKSSGKNDAKFFSRTHEYILVYAKNKSYLKFNG--LPRTEEQLKRYKNP 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871 161 D------YRKNPPQ--------------PYNHQKV-PGNVWDFP------------------------RVRYL------- 188
Cdd:COG2189  194 DndprgrWRSVPLTapggrpnlfypiehPSTGKEVyPGRGWRWSketmeeliadgriyfgkdgngvprRKRYLdevkkgv 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871 189 ------MDEYENH---------------PTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAIASG------RKFIG 241
Cdd:COG2189  274 vpttiwDDIGTNQngtkelkelfggkvfDTPKPEKLLKRIIEIATNPGDLVLDFFAGSGTTAHAVMKLNaedggnRRFIL 353

                        330
                 ....*....|....*
gi 999848871 242 IEINSEYIKMGLRRL 256
Cdd:COG2189  354 VQLGEYADTVTKERL 368
PRK13699 PRK13699
putative methylase; Provisional
 18-256 8.54e-23

putative methylase; Provisional


Pssm-ID: 184255  Cd Length: 227  Bit Score: 93.75  E-value: 8.54e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871  18 IHGDALAELKKIPAESVDLIFADPPYNIG-KNFDGLIEAwkEDLFIDWLFEVIAECHRVLKKQG---SMYIMNSTENmpF 93
Cdd:PRK13699   5 ILGNCIDVMARFPDNAVDFILTDPPYLVGfRDRQGRTIA--GDKTDEWLQPACNEMYRVLKKDAlmvSFYGWNRVDR--F 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871  94 IDLQCRKLFTIKSRIVWsydssgvqakkhygsmyepilmmvkdAKNYTfngdailveaktgSQRALIDYR--------KN 165
Cdd:PRK13699  81 MAAWKNAGFSVVGHLVF--------------------------TKNYT-------------SKAAYVGYRhecayilaKG 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871 166 PPQPyNHQKVPGNV-WDFPRVRYlmdeyenHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAIASGRKFIGIEI 244
Cdd:PRK13699 122 RPAL-PQNPLPDVLgWKYSGNRH-------HPTEKPVTSLQPLIESFTHPNAIVLDPFAGSGSTCVAALQSGRRYIGIEL 193

                        250
                 ....*....|..
gi 999848871 245 NSEYIKMGLRRL 256
Cdd:PRK13699 194 LEQYHRAGQQRL 205
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 192-266 5.17e-07

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 48.79  E-value: 5.17e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 999848871 192 YENHPTQKPEALLKRII-LASSNPGDIVLDPFAGsftTGAVAIA---SGRKFIGIEINSEYIKMGLRRLDvasHYSAEE 266
Cdd:COG1041    3 YFFYPGSLDPRLARALVnLAGAKEGDTVLDPFCG---TGTILIEaglLGRRVIGSDIDPKMVEGARENLE---HYGYED 75
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 16-46 2.50e-06

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 47.00  E-value: 2.50e-06
                         10        20        30
                 ....*....|....*....|....*....|.
gi 999848871  16 TIIHGDALAELKKIPAESVDLIFADPPYNIG 46
Cdd:COG0742   94 RVIRGDALRFLKRLAGEPFDLVFLDPPYAKG 124
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 10-108 6.41e-06

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 45.71  E-value: 6.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871  10 FGNEAKTIIHGDAlAELKkIPAESVDLIFADPPYNI-----GKNFDGLIEawkedlfidwlfEVIAECHRVLKKQGSMYI 84
Cdd:COG1041   71 YGYEDADVIRGDA-RDLP-LADESVDAIVTDPPYGRsskisGEELLELYE------------KALEEAARVLKPGGRVVI 136

                         90       100
                 ....*....|....*....|....
gi 999848871  85 MnstENMPFIDLQCRKLFTIKSRI 108
Cdd:COG1041  137 V---TPRDIDELLEEAGFKVLERH 157
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 16-85 1.83e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 40.11  E-value: 1.83e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871  16 TIIHGDALaELKKIPAESVDLIFADPPYnigknfdgliEAWKEDlfidwLFEVIAECHRVLKKQGSMYIM 85
Cdd:cd02440   50 EVLKGDAE-ELPPEADESFDVIISDPPL----------HHLVED-----LARFLEEARRLLKPGGVLVLT 103
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
10-93 4.84e-04

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 40.30  E-value: 4.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871   10 FGNEAKTIIHGDALAELKKIPA-ESVDLIFADPPYNigknfDGLIEAwkedlfidwLFEVIAEcHRVLKKQGSMYIMNST 88
Cdd:pfam03602  87 LGLPGAVLVMDALLALLRLAGKgPVFDIVFLDPPYA-----KGLIEE---------VLDLLAE-KGWLKPNALIYVETEK 151


                  ....*
gi 999848871   89 ENMPF 93
Cdd:pfam03602 152 RGELP 156
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
12-42 1.61e-03

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 39.51  E-value: 1.61e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 999848871  12 NEAKTIIHGDALAELKKIPAESVDLIFADPP 42
Cdd:COG2521  182 NERIKIILGDASEVIKTFPDESFDAIIHDPP 212
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
11-84 6.61e-03

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 37.09  E-value: 6.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871  11 GNEAKTIIHGDALAElKKIPAESVDLIFADPPYNIGKNFDGLIEAWKEDLF--------IDWLFevIAECHRVLKKQGSM 82
Cdd:COG0286   99 GIGDPNIELGDTLSN-DGDELEKFDVVLANPPFGGKWKKEELKDDLLGRFGyglppksnADLLF--LQHILSLLKPGGRA 175


                 ..
gi 999848871  83 YI 84
Cdd:COG0286  176 AV 177
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 16-112 6.73e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 37.05  E-value: 6.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999848871  16 TIIHGDALAELKKIPAESVDLIFADPPYNigKNFDGLI-------EAWKEDL--FIDWlfevIAECHRVLKKQGSMYIMN 86
Cdd:COG4123   91 TVIHGDLKEFAAELPPGSFDLVVSNPPYF--KAGSGRKspdearaIARHEDAltLEDL----IRAAARLLKPGGRFALIH 164

                         90       100
                 ....*....|....*....|....*...
gi 999848871  87 STENMPFIDLQCRK--LFTIKSRIVWSY 112
Cdd:COG4123  165 PAERLAEILAALRKygLGPKRLRPVHPR 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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