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Conserved domains on  [gi|1039017325|gb|ANM66702|]
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Putative CDP-diacylglycerol-inositol 3-phosphatidyltransferase 2 [Arabidopsis thaliana]

Protein Classification

CDP-alcohol phosphatidyltransferase family protein( domain architecture ID 10001704)

CDP-alcohol phosphatidyltransferase family protein catalyzes the transfer of a substituted phosphate group from a cytidine-5'-diphosphate-linked donor to an alcohol acceptor, an essential reaction in the biosynthesis of phospholipids

CATH:  1.20.120.1760
EC:  2.7.8.-
Gene Ontology:  GO:0016780|GO:0008654|GO:0016020|GO:0000287
PubMed:  24923293|24573438|21259003|24942835
SCOP:  3002413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 13-107 5.76e-14

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 67.19  E-value: 5.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039017325  13 LYIPNIVGYMRVLLNCIAFSVCFSNKTLF--SLLYFFSFCCDAVDGWCARKFNQVSTFGAVLDMVTDRVSTACLLVILSQ 90
Cdd:COG0558     9 LNIPNQLTLLRILLVPVFALLLLLGGALLlaLVLFLLAGLTDALDGYLARRLGQVSRFGAFLDPVADKLLDAAALLGLVL 88

                          90
                  ....*....|....*...
gi 1039017325  91 IYR-PSLVFLSLLALDIA 107
Cdd:COG0558    89 LGLlPAWLALLILLRELL 106
 
Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 13-107 5.76e-14

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 67.19  E-value: 5.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039017325  13 LYIPNIVGYMRVLLNCIAFSVCFSNKTLF--SLLYFFSFCCDAVDGWCARKFNQVSTFGAVLDMVTDRVSTACLLVILSQ 90
Cdd:COG0558     9 LNIPNQLTLLRILLVPVFALLLLLGGALLlaLVLFLLAGLTDALDGYLARRLGQVSRFGAFLDPVADKLLDAAALLGLVL 88

                          90
                  ....*....|....*...
gi 1039017325  91 IYR-PSLVFLSLLALDIA 107
Cdd:COG0558    89 LGLlPAWLALLILLRELL 106
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
 13-104 2.86e-10

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 56.80  E-value: 2.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039017325  13 LYIPNIVGYMRVLLnCIAFSVCF---SNKTLFSLLYFFSFCCDAVDGWCARKFNQVSTFGAVLDMVTDRVSTACLLVILS 89
Cdd:pfam01066   1 LNLPNLLTLLRILL-VPVFVVLLlgpGNRILAAVVFALAALTDFLDGKIARKLNQVTDFGKFLDPLADKLLVAAALIALS 79

                          90
                  ....*....|....*
gi 1039017325  90 QIYRPSLVFLSLLAL 104
Cdd:pfam01066  80 ILGLLPWWFVVVILV 94
PRK10832 PRK10832
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;
13-92 1.87e-05

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;


Pssm-ID: 182763 [Multi-domain]  Cd Length: 182  Bit Score: 43.68  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039017325  13 LYIPNIVGYMRVLL---NCIAFSVCFSNKTLF-SLLYFFSFCCDAVDGWCARKFNQVSTFGAVLDMVTDRVSTACLLVIL 88
Cdd:PRK10832    3 FNIPTLLTLFRVILipfFVLVFYLPFTWAPFVcALIFCVAAVTDWFDGFLARRWNQSTRFGAFLDPVADKVMVAIAMVLV 82


                  ....
gi 1039017325  89 SQIY 92
Cdd:PRK10832   83 TEHY 86
pssA TIGR00473
CDP-diacylglycerol--serine O-phosphatidyltransferase; This enzyme, CDP-diacylglycerol--serine ...
 43-80 4.89e-03

CDP-diacylglycerol--serine O-phosphatidyltransferase; This enzyme, CDP-diacylglycerol--serine O-phosphatidyltransferase, is involved in phospholipid biosynthesis catalyzing the reaction CDP-diacylglycerol + L-serine = CMP + L-1-phosphatidylserine. Members of this family do not bear any significant sequence similarity to the corresponding E.coli protein. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273098  Cd Length: 151  Bit Score: 36.27  E-value: 4.89e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1039017325  43 LLYFFSFCCDAVDGWCARKFNQVSTFGAVLDMVTDRVS 80
Cdd:TIGR00473  25 FLILLSMFFDFLDGRVARKTNRVSDFGKELDSLADVVS 62
 
Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 13-107 5.76e-14

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 67.19  E-value: 5.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039017325  13 LYIPNIVGYMRVLLNCIAFSVCFSNKTLF--SLLYFFSFCCDAVDGWCARKFNQVSTFGAVLDMVTDRVSTACLLVILSQ 90
Cdd:COG0558     9 LNIPNQLTLLRILLVPVFALLLLLGGALLlaLVLFLLAGLTDALDGYLARRLGQVSRFGAFLDPVADKLLDAAALLGLVL 88

                          90
                  ....*....|....*...
gi 1039017325  91 IYR-PSLVFLSLLALDIA 107
Cdd:COG0558    89 LGLlPAWLALLILLRELL 106
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
 13-104 2.86e-10

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 56.80  E-value: 2.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039017325  13 LYIPNIVGYMRVLLnCIAFSVCF---SNKTLFSLLYFFSFCCDAVDGWCARKFNQVSTFGAVLDMVTDRVSTACLLVILS 89
Cdd:pfam01066   1 LNLPNLLTLLRILL-VPVFVVLLlgpGNRILAAVVFALAALTDFLDGKIARKLNQVTDFGKFLDPLADKLLVAAALIALS 79

                          90
                  ....*....|....*
gi 1039017325  90 QIYRPSLVFLSLLAL 104
Cdd:pfam01066  80 ILGLLPWWFVVVILV 94
PRK10832 PRK10832
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;
13-92 1.87e-05

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;


Pssm-ID: 182763 [Multi-domain]  Cd Length: 182  Bit Score: 43.68  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039017325  13 LYIPNIVGYMRVLL---NCIAFSVCFSNKTLF-SLLYFFSFCCDAVDGWCARKFNQVSTFGAVLDMVTDRVSTACLLVIL 88
Cdd:PRK10832    3 FNIPTLLTLFRVILipfFVLVFYLPFTWAPFVcALIFCVAAVTDWFDGFLARRWNQSTRFGAFLDPVADKVMVAIAMVLV 82


                  ....
gi 1039017325  89 SQIY 92
Cdd:PRK10832   83 TEHY 86
PLN02558 PLN02558
CDP-diacylglycerol-glycerol-3-phosphate/ 3-phosphatidyltransferase
 10-100 7.30e-04

CDP-diacylglycerol-glycerol-3-phosphate/ 3-phosphatidyltransferase


Pssm-ID: 166199  Cd Length: 203  Bit Score: 39.24  E-value: 7.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039017325  10 SVYLYIPNIVGYMRV----LLNCIAFSVCFSNKTLFSLLYFFSFCCDAVDGWCARKFNQVSTFGAVLDMVTDRVSTACLL 85
Cdd:PLN02558    6 SKVLTLPTVLTLGRVaavpLLVATFYVDSWWGRTATTSIFIAAAITDWLDGYLARKMKLGTAFGAFLDPVADKLMVAAAL 85

                          90
                  ....*....|....*
gi 1039017325  86 VILSQiyRPSLVFLS 100
Cdd:PLN02558   86 ILLCS--RPLEVAVL 98
pssA TIGR00473
CDP-diacylglycerol--serine O-phosphatidyltransferase; This enzyme, CDP-diacylglycerol--serine ...
 43-80 4.89e-03

CDP-diacylglycerol--serine O-phosphatidyltransferase; This enzyme, CDP-diacylglycerol--serine O-phosphatidyltransferase, is involved in phospholipid biosynthesis catalyzing the reaction CDP-diacylglycerol + L-serine = CMP + L-1-phosphatidylserine. Members of this family do not bear any significant sequence similarity to the corresponding E.coli protein. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273098  Cd Length: 151  Bit Score: 36.27  E-value: 4.89e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1039017325  43 LLYFFSFCCDAVDGWCARKFNQVSTFGAVLDMVTDRVS 80
Cdd:TIGR00473  25 FLILLSMFFDFLDGRVARKTNRVSDFGKELDSLADVVS 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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