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Conserved domains on  [gi|1044515115|gb|ANT63823|]
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integrase (plasmid) [Salipiger sp. CCB-MM3]

Protein Classification

transposase family protein( domain architecture ID 1750059)

transposase family protein might bind to the end of a transposon and catalyze the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0003677|GO:0006313
PubMed:  11774877

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
6-258 2.51e-88

IS3 family transposase;


:

Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 267.12  E-value: 2.51e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115   6 GISERRACRVLGQHRST-----QRKPPQGREDEARLTADVIDLAREY-GRYGYRRVAVLLRRAGWQVNHKRVARIWRREG 79
Cdd:NF033516  100 EYSVRRACRVLGVSRSTyyywrKRPPSRRAPDDAELRARIREIFEESrGRYGYRRITALLRREGIRVNHKRVYRLMRELG 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  80 LKVVPHKQKKRGRLW-------LDDGSCVRLKPEHPNHVWSYDFVQDRTSDGRtYRTLNILDEYTREALMIRVDRRLNST 152
Cdd:NF033516  180 LLARRRRKRRPYTTDsghvhpvAPNLLNRQFTATRPNQVWVTDITYIRTAEGW-LYLAVVLDLFSREIVGWSVSTSMSAE 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115 153 DVLDALTDLFIQRGPPR--FIRSDNGPEFIAQKVRDWIELVGAKTAYIEPGSPWENGYCESFNSRFRDELLNGEVFYSLR 230
Cdd:NF033516  259 LVLDALEMAIEWRGKPEglILHSDNGSQYTSKAYREWLKEHGITQSMSRPGNCWDNAVAESFFGTLKRECLYRRRFRTLE 338

                         250       260
                  ....*....|....*....|....*...
gi 1044515115 231 EAQILIEQWRKHYNTARPHSALGYRTPA 258
Cdd:NF033516  339 EARQAIEEYIEFYNHERPHSSLGYLTPA 366
 
Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
6-258 2.51e-88

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 267.12  E-value: 2.51e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115   6 GISERRACRVLGQHRST-----QRKPPQGREDEARLTADVIDLAREY-GRYGYRRVAVLLRRAGWQVNHKRVARIWRREG 79
Cdd:NF033516  100 EYSVRRACRVLGVSRSTyyywrKRPPSRRAPDDAELRARIREIFEESrGRYGYRRITALLRREGIRVNHKRVYRLMRELG 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  80 LKVVPHKQKKRGRLW-------LDDGSCVRLKPEHPNHVWSYDFVQDRTSDGRtYRTLNILDEYTREALMIRVDRRLNST 152
Cdd:NF033516  180 LLARRRRKRRPYTTDsghvhpvAPNLLNRQFTATRPNQVWVTDITYIRTAEGW-LYLAVVLDLFSREIVGWSVSTSMSAE 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115 153 DVLDALTDLFIQRGPPR--FIRSDNGPEFIAQKVRDWIELVGAKTAYIEPGSPWENGYCESFNSRFRDELLNGEVFYSLR 230
Cdd:NF033516  259 LVLDALEMAIEWRGKPEglILHSDNGSQYTSKAYREWLKEHGITQSMSRPGNCWDNAVAESFFGTLKRECLYRRRFRTLE 338

                         250       260
                  ....*....|....*....|....*...
gi 1044515115 231 EAQILIEQWRKHYNTARPHSALGYRTPA 258
Cdd:NF033516  339 EARQAIEEYIEFYNHERPHSSLGYLTPA 366
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
10-258 6.82e-73

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 225.42  E-value: 6.82e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  10 RRACRVLGQHRSTQRKPPQGREDEARLTADVIDLAREYGRYGYRRVAVLLRRAGWQVNHKRVARIWRREGLKVVPHKQKK 89
Cdd:COG2801    47 RRRRARSRRRRRLRRPRSYRADEDAELLERIKEIFAESPRYGYRRITAELRREGIAVNRKRVRRLMRELGLQARRRRKKK 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  90 RG---RLWLDDGSCVRLKPEHPNHVWSYDFVQDRTSDGRTYrTLNILDEYTREALMIRVDRRLNSTDVLDALTDLFIQRG 166
Cdd:COG2801   127 YTtysGHGGPIAPNLLFTATAPNQVWVTDITYIPTAEGWLY-LAAVIDLFSREIVGWSVSDSMDAELVVDALEMAIERRG 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115 167 P--PRFIRSDNGPEFIAQKVRDWIELVGAKTAYIEPGSPWENGYCESFNSRFRDELLNGEVFYSLREAQILIEQWRKHYN 244
Cdd:COG2801   206 PpkPLILHSDNGSQYTSKAYQELLKKLGITQSMSRPGNPQDNAFIESFFGTLKYELLYRRRFESLEEAREAIEEYIEFYN 285

                         250
                  ....*....|....
gi 1044515115 245 TARPHSALGYRTPA 258
Cdd:COG2801   286 HERPHSSLGYLTPA 299
transpos_IS481 NF033577
IS481 family transposase; null
 2-258 9.69e-34

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 123.47  E-value: 9.69e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115   2 CETLGISERRACRVLGQHRSTQRKPPQGR-------------EDEARltadVIDLAREYgRYGYRRVAVLLRRAGWQVNH 68
Cdd:NF033577   20 ARRFGISRKTVYKWLKRYRAGGEEGLIDRsrrphrsprrtspETEAR----ILALRREL-RLGPRRIAYELERQGPGVSR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  69 KRVARIWRREGLKVVPHKQKKRGRLwlddgscVRLKPEHPNHVWSYDFVQDRTSDGRTYRTL-NILDEYTREALmIRVDR 147
Cdd:NF033577   95 STVHRILRRHGLSRLRALDRKTGKV-------KRYERAHPGELWHIDIKKLGRIPDVGRLYLhTAIDDHSRFAY-AELYP 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115 148 RLNSTDVLDALTDLFIQRGPP-RFIRSDNGPEFIA--QKVRDWIELVGAKTAYIEPGSPWENGYCESFNSRFRDELLNGE 224
Cdd:NF033577  167 DETAETAADFLRRAFAEHGIPiRRVLTDNGSEFRSraHGFELALAELGIEHRRTRPYHPQTNGKVERFHRTLKDEFAYAR 246

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1044515115 225 VFYSLREAQILIEQWRKHYNTARPHSALGYRTPA 258
Cdd:NF033577  247 PYESLAELQAALDEWLHHYNHHRPHSALGGKTPA 280
rve_3 pfam13683
Integrase core domain;
192-257 4.24e-32

Integrase core domain;


Pssm-ID: 433402 [Multi-domain]  Cd Length: 67  Bit Score: 112.69  E-value: 4.24e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1044515115 192 GAKTAYIEPGSPWENGYCESFNSRFRDELLNGEVFYSLREAQILIEQWRKHYNTARPHSALGYRTP 257
Cdd:pfam13683   2 GIEISYIAPGKPMQNGLVESFNGTLRDECLNEHLFSSLAEARALLAAWREDYNTERPHSSLGYRTP 67
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 16-258 6.27e-20

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 86.84  E-value: 6.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  16 LGQHRST------QRKPPQGR----EDEARLTADVIDLARE-YGRYGYRRVAVLLRRAGWQVNHKRVARIWRREGLKVV- 83
Cdd:PHA02517    1 LGIAPSTyyrcqqQRHHPDKRraraQHDDWLKSEILRVYDEnHQVYGVRKVWRQLNREGIRVARCTVGRLMKELGLAGVl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  84 --PHKQKKRGRLWLDDGSCVR--LKPEHPNHVWSYDFVQDRTSDGRTYRTLnILDEYTREALMIRVDRRLNSTDVLDALT 159
Cdd:PHA02517   81 rgKKVRTTISRKAVAAPDRVNrqFVATRPNQLWVADFTYVSTWQGWVYVAF-IIDVFARRIVGWRVSSSMDTDFVLDALE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115 160 DLFIQRGPPR--FIRSDNGPEFIAQKVRDWIELVGAKTAYIEPGSPWENGYCESFNSRFRDELLNGEVFYSLREAQILIE 237
Cdd:PHA02517  160 QALWARGRPGglIHHSDKGSQYVSLAYTQRLKEAGIRASTGSRGDSYDNAPAESINGLYKAEVIHRVSWKNREEVELATL 239

                         250       260
                  ....*....|....*....|.
gi 1044515115 238 QWRKHYNTARPHSALGYRTPA 258
Cdd:PHA02517  240 EWVAWYNNRRLHERLGYTPPA 260
transpos_IS630 NF033545
IS630 family transposase;
6-239 5.18e-04

IS630 family transposase;


Pssm-ID: 468076 [Multi-domain]  Cd Length: 298  Bit Score: 40.70  E-value: 5.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115   6 GISERRACRVLGQHRST----------------QRKPPQGR------EDEARLTADVID-LAREYGRYGYRRVAVLLRRA 62
Cdd:NF033545   12 GLSITEIAERLGVSRSTvyrwlkrfneggleglLDKPRPGRprkllsEQQAELLALLLEePPEGAGHWTLRELAALLEEE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  63 -GWQVNHKRVARIWRREGLKV-----VPHKQKKRGRLWLDDGSCVRLKPEHPNHVWSYD---FVQD-------------- 119
Cdd:NF033545   92 fGVEYSRSTVRRLLKRLGLSPkkprpRAPKQDPEFVEKFKEVLGLYRAPPDPAEVVFIDesgIQLLdtrgrgwapkgqrr 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115 120 -RTSDGRTYRTLNIL--DEYTREALMIRVDRRLNSTDVLDALTDLFIQ-RGPPRFIRSDNGPEFIAQKVRDWIELVG-AK 194
Cdd:NF033545  172 pRVHVYGRRGTLNLFgaLDPLTGKVFVLFTGRINSEDFIEFLEELLAAyPGKKIHLILDNASTHKSKKVREWLEEHGrIE 251

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1044515115 195 TAYIEPGSPWENgYCESFNSRFRDELLNGEVFYSLREAQILIEQW 239
Cdd:NF033545  252 LHYLPPYSPWLN-PIERVWAVLKRRLLRNRAFRSVDELREAIDAF 295
HAD-SF-IIIA TIGR01662
HAD-superfamily hydrolase, subfamily IIIA; This subfamily falls within the Haloacid ...
 22-96 1.25e-03

HAD-superfamily hydrolase, subfamily IIIA; This subfamily falls within the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The Class III subfamilies are characterized by the lack of any domains located between either between the first and second conserved catalytic motifs (as in the Class I subfamilies, TIGR01493, TIGR01509, TIGR01488 and TIGR01494) or between the second and third conserved catalytic motifs (as in the Class II subfamilies, TIGR01460 and TIGR01484) of the superfamily domain. The IIIA subfamily contains five major clades: histidinol-phosphatase (TIGR01261) and histidinol-phosphatase-related protein (TIGR00213) which together form a subfamily (TIGR01656), DNA 3'-phosphatase (TIGR01663, TIGR01664), YqeG (TIGR01668) and YrbI (TIGR01670). In the case of histidinol phosphatase and PNK-3'-phosphatase, this model represents a domain of a bifunctional system. In the histidinol phosphatase HisB, a C-terminal domain is an imidazoleglycerol-phosphate dehydratase which catalyzes a related step in histidine biosynthesis. In PNK-3'-phosphatase, N- and C-terminal domains constitute the polynucleotide kinase and DNA-binding components of the enzyme. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273742 [Multi-domain]  Cd Length: 135  Bit Score: 38.15  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  22 TQRKPPQGREDEARLTADVIDLAREYGRYGYrRVAVL------LRRAGWQVNHKRVARIWRREGLKV-----VPHKQKKR 90
Cdd:TIGR01662  12 TDDVPYVSDEDERILYPEVPDALAELKEAGY-KVVIVtnqsgiGRGYFSRSFSGRVARRLEELGVPIdilyaCPGCRKPK 90


                  ....*.
gi 1044515115  91 GRLWLD 96
Cdd:TIGR01662  91 PGMFLE 96
 
Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
6-258 2.51e-88

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 267.12  E-value: 2.51e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115   6 GISERRACRVLGQHRST-----QRKPPQGREDEARLTADVIDLAREY-GRYGYRRVAVLLRRAGWQVNHKRVARIWRREG 79
Cdd:NF033516  100 EYSVRRACRVLGVSRSTyyywrKRPPSRRAPDDAELRARIREIFEESrGRYGYRRITALLRREGIRVNHKRVYRLMRELG 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  80 LKVVPHKQKKRGRLW-------LDDGSCVRLKPEHPNHVWSYDFVQDRTSDGRtYRTLNILDEYTREALMIRVDRRLNST 152
Cdd:NF033516  180 LLARRRRKRRPYTTDsghvhpvAPNLLNRQFTATRPNQVWVTDITYIRTAEGW-LYLAVVLDLFSREIVGWSVSTSMSAE 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115 153 DVLDALTDLFIQRGPPR--FIRSDNGPEFIAQKVRDWIELVGAKTAYIEPGSPWENGYCESFNSRFRDELLNGEVFYSLR 230
Cdd:NF033516  259 LVLDALEMAIEWRGKPEglILHSDNGSQYTSKAYREWLKEHGITQSMSRPGNCWDNAVAESFFGTLKRECLYRRRFRTLE 338

                         250       260
                  ....*....|....*....|....*...
gi 1044515115 231 EAQILIEQWRKHYNTARPHSALGYRTPA 258
Cdd:NF033516  339 EARQAIEEYIEFYNHERPHSSLGYLTPA 366
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
10-258 6.82e-73

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 225.42  E-value: 6.82e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  10 RRACRVLGQHRSTQRKPPQGREDEARLTADVIDLAREYGRYGYRRVAVLLRRAGWQVNHKRVARIWRREGLKVVPHKQKK 89
Cdd:COG2801    47 RRRRARSRRRRRLRRPRSYRADEDAELLERIKEIFAESPRYGYRRITAELRREGIAVNRKRVRRLMRELGLQARRRRKKK 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  90 RG---RLWLDDGSCVRLKPEHPNHVWSYDFVQDRTSDGRTYrTLNILDEYTREALMIRVDRRLNSTDVLDALTDLFIQRG 166
Cdd:COG2801   127 YTtysGHGGPIAPNLLFTATAPNQVWVTDITYIPTAEGWLY-LAAVIDLFSREIVGWSVSDSMDAELVVDALEMAIERRG 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115 167 P--PRFIRSDNGPEFIAQKVRDWIELVGAKTAYIEPGSPWENGYCESFNSRFRDELLNGEVFYSLREAQILIEQWRKHYN 244
Cdd:COG2801   206 PpkPLILHSDNGSQYTSKAYQELLKKLGITQSMSRPGNPQDNAFIESFFGTLKYELLYRRRFESLEEAREAIEEYIEFYN 285

                         250
                  ....*....|....
gi 1044515115 245 TARPHSALGYRTPA 258
Cdd:COG2801   286 HERPHSSLGYLTPA 299
transpos_IS481 NF033577
IS481 family transposase; null
 2-258 9.69e-34

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 123.47  E-value: 9.69e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115   2 CETLGISERRACRVLGQHRSTQRKPPQGR-------------EDEARltadVIDLAREYgRYGYRRVAVLLRRAGWQVNH 68
Cdd:NF033577   20 ARRFGISRKTVYKWLKRYRAGGEEGLIDRsrrphrsprrtspETEAR----ILALRREL-RLGPRRIAYELERQGPGVSR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  69 KRVARIWRREGLKVVPHKQKKRGRLwlddgscVRLKPEHPNHVWSYDFVQDRTSDGRTYRTL-NILDEYTREALmIRVDR 147
Cdd:NF033577   95 STVHRILRRHGLSRLRALDRKTGKV-------KRYERAHPGELWHIDIKKLGRIPDVGRLYLhTAIDDHSRFAY-AELYP 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115 148 RLNSTDVLDALTDLFIQRGPP-RFIRSDNGPEFIA--QKVRDWIELVGAKTAYIEPGSPWENGYCESFNSRFRDELLNGE 224
Cdd:NF033577  167 DETAETAADFLRRAFAEHGIPiRRVLTDNGSEFRSraHGFELALAELGIEHRRTRPYHPQTNGKVERFHRTLKDEFAYAR 246

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1044515115 225 VFYSLREAQILIEQWRKHYNTARPHSALGYRTPA 258
Cdd:NF033577  247 PYESLAELQAALDEWLHHYNHHRPHSALGGKTPA 280
rve_3 pfam13683
Integrase core domain;
192-257 4.24e-32

Integrase core domain;


Pssm-ID: 433402 [Multi-domain]  Cd Length: 67  Bit Score: 112.69  E-value: 4.24e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1044515115 192 GAKTAYIEPGSPWENGYCESFNSRFRDELLNGEVFYSLREAQILIEQWRKHYNTARPHSALGYRTP 257
Cdd:pfam13683   2 GIEISYIAPGKPMQNGLVESFNGTLRDECLNEHLFSSLAEARALLAAWREDYNTERPHSSLGYRTP 67
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 16-258 6.27e-20

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 86.84  E-value: 6.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  16 LGQHRST------QRKPPQGR----EDEARLTADVIDLARE-YGRYGYRRVAVLLRRAGWQVNHKRVARIWRREGLKVV- 83
Cdd:PHA02517    1 LGIAPSTyyrcqqQRHHPDKRraraQHDDWLKSEILRVYDEnHQVYGVRKVWRQLNREGIRVARCTVGRLMKELGLAGVl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  84 --PHKQKKRGRLWLDDGSCVR--LKPEHPNHVWSYDFVQDRTSDGRTYRTLnILDEYTREALMIRVDRRLNSTDVLDALT 159
Cdd:PHA02517   81 rgKKVRTTISRKAVAAPDRVNrqFVATRPNQLWVADFTYVSTWQGWVYVAF-IIDVFARRIVGWRVSSSMDTDFVLDALE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115 160 DLFIQRGPPR--FIRSDNGPEFIAQKVRDWIELVGAKTAYIEPGSPWENGYCESFNSRFRDELLNGEVFYSLREAQILIE 237
Cdd:PHA02517  160 QALWARGRPGglIHHSDKGSQYVSLAYTQRLKEAGIRASTGSRGDSYDNAPAESINGLYKAEVIHRVSWKNREEVELATL 239

                         250       260
                  ....*....|....*....|.
gi 1044515115 238 QWRKHYNTARPHSALGYRTPA 258
Cdd:PHA02517  240 EWVAWYNNRRLHERLGYTPPA 260
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 108-203 1.75e-17

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 1.75e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115 108 PNHVWSYDFVQDRTSD-GRTYRTLNILDEYTREALMIRVDRRLNSTDVLDALTDLFIQRGP-PRFIRSDNGPEFIAQKVR 185
Cdd:pfam00665   1 PNQLWQGDFTYIRIPGgGGKLYLLVIVDDFSREILAWALSSEMDAELVLDALERAIAFRGGvPLIIHSDNGSEYTSKAFR 80

                          90
                  ....*....|....*...
gi 1044515115 186 DWIELVGAKTAYIEPGSP 203
Cdd:pfam00665  81 EFLKDLGIKPSFSRPGNP 98
Tra8 COG2826
Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];
137-258 2.74e-14

Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];


Pssm-ID: 442074 [Multi-domain]  Cd Length: 325  Bit Score: 71.45  E-value: 2.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115 137 TREALMIRVDRRlNSTDVLDALTDLFiQRGPPRFIRS---DNGPEFiaqkvRDWIEL---VGAKTAYIEPGSPWENGYCE 210
Cdd:COG2826   197 SRFVILLKLPDK-TAESVADALIRLL-RKLPAFLRKSittDNGKEF-----ADHKEIeaaLGIKVYFADPYSPWQRGTNE 269

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1044515115 211 SFNSRFRDELLNGEVFYSLREAQIliEQWRKHYNTaRPHSALGYRTPA 258
Cdd:COG2826   270 NTNGLLRQYFPKGTDFSTVTQEEL--DAIADRLNN-RPRKCLGYKTPA 314
PRK09409 PRK09409
IS2 transposase TnpB; Reviewed
 46-257 1.25e-12

IS2 transposase TnpB; Reviewed


Pssm-ID: 181829 [Multi-domain]  Cd Length: 301  Bit Score: 66.66  E-value: 1.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  46 EYGRYGYRRVAVLLRRAGW-----QVNHKRVARIWRREGL------KVVPHKQKKRGRLWLDDGscvrlkpehpNHVWSY 114
Cdd:PRK09409   62 ELPTYGYRRVWALLRRQAEldgmpAINAKRVYRIMRQNALllerkpAVPPSKRAHTGRVAVKES----------NQRWCS 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115 115 DFVQDRTSDGRTYRTLNILDEYTREALMIRVDRR-LNSTDVLDALTDLFIQR------GPPRFIRSDNGPEFIAQKVRDW 187
Cdd:PRK09409  132 DGFEFCCDNGERLRVTFALDCCDREALHWAVTTGgFNSETVQDVMLGAVERRfgndlpSSPVEWLTDNGSCYRANETRQF 211

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1044515115 188 IELVGAKTAYIEPGSPWENGYCESFNSRF-RDELLNGEVFYSLREAQILIEQWrKHYNTARPHSALGYRTP 257
Cdd:PRK09409  212 ARMLGLEPKNTAVRSPESNGIAESFVKTIkRDYISIMPKPDGLTAAKNLAEAF-EHYNEWHPHSALGYRSP 281
PRK14702 PRK14702
insertion element IS2 transposase InsD; Provisional
 46-257 1.21e-11

insertion element IS2 transposase InsD; Provisional


Pssm-ID: 237792 [Multi-domain]  Cd Length: 262  Bit Score: 63.21  E-value: 1.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  46 EYGRYGYRRVAVLLRRAGW-----QVNHKRVARIWRREGL------KVVPHKQKKRGRLWLDDGscvrlkpehpNHVWSY 114
Cdd:PRK14702   23 ELPTYGYRRVWALLRRQAEldgmpAINAKRVYRLMRQNALllerkpAVPPSKRAHTGRVAVKES----------NQRWCS 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115 115 DFVQDRTSDGRTYRTLNILDEYTREAL-MIRVDRRLNSTDVLDALTDLFIQR------GPPRFIRSDNGPEFIAQKVRDW 187
Cdd:PRK14702   93 DGFEFCCDNGERLRVTFALDCCDREALhWAVTTGGFNSETVQDVMLGAVERRfgndlpSSPVEWLTDNGSCYRANETRQF 172

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1044515115 188 IELVGAKTAYIEPGSPWENGYCESFNSRF-RDELLNGEVFYSLREAQILIEQWrKHYNTARPHSALGYRTP 257
Cdd:PRK14702  173 ARMLGLEPKNTAVRSPESNGIAESFVKTIkRDYISIMPKPDGLTAAKNLAEAF-EHYNEWHPHSALGYRSP 242
HTH_21 pfam13276
HTH-like domain; This domain contains a predicted helix-turn-helix suggesting a DNA-binding ...
 31-88 6.54e-10

HTH-like domain; This domain contains a predicted helix-turn-helix suggesting a DNA-binding function.


Pssm-ID: 463824 [Multi-domain]  Cd Length: 60  Bit Score: 53.73  E-value: 6.54e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  31 EDEARLTADVIDLARE-YGRYGYRRVAVLLRRAGW-QVNHKRVARIWRREGLKVVPHKQK 88
Cdd:pfam13276   1 ELEDELLEAIREIFEEsRGTYGYRRITAELRREGGiRVNRKRVARLMRELGLRARRRRKR 60
COG3335 COG3335
Transposase [Mobilome: prophages, transposons];
14-256 2.40e-05

Transposase [Mobilome: prophages, transposons];


Pssm-ID: 442564 [Multi-domain]  Cd Length: 292  Bit Score: 44.86  E-value: 2.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  14 RVLGQHRSTQRKPPQGREDEARLTADVIDLAREYGRYGYRRVAVLLRRAGWQVNHKRVARIWRREGLKVVPHKQKKRGRL 93
Cdd:COG3335    37 RLGRRRLKVRLGPRALGSDLARPQELLLKALQQLGLKLRAALRELLERLEERAAATSSSRGRRRRRGRRKGKQRKKRRAA 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  94 WLDDGS------CVRLKPEHPNHVWSYDFVQDRTSDGRTYRTLNI---LDEYTREALMiRVDRRLNSTDVLDALTDLFIQ 164
Cdd:COG3335   117 KKAKAGkrrrgeRLALLRKLSAGAAVLVVLDAGDPTSGGGKRTNLigaLNLDGGLAVM-VFDGSINGEVFIAFLEQLLLP 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115 165 -RGPPRFIRSDNGPEFIAQKVRDWIELVGAKTAYIEPGSPWENGyCESFNSRFRDELLNGEVFYSLREAQILIEQWRKHY 243
Cdd:COG3335   196 yLKPGIVVILDNASFHKSKAVREWLEEAGIELLFLPPYSPDLNP-IERLWSKLKALLRKNRAFRSKDELKAAVRSFLDRI 274

                         250
                  ....*....|...
gi 1044515115 244 NtARPHSALGYRT 256
Cdd:COG3335   275 S-PDPERVRNWFR 286
transpos_IS630 NF033545
IS630 family transposase;
6-239 5.18e-04

IS630 family transposase;


Pssm-ID: 468076 [Multi-domain]  Cd Length: 298  Bit Score: 40.70  E-value: 5.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115   6 GISERRACRVLGQHRST----------------QRKPPQGR------EDEARLTADVID-LAREYGRYGYRRVAVLLRRA 62
Cdd:NF033545   12 GLSITEIAERLGVSRSTvyrwlkrfneggleglLDKPRPGRprkllsEQQAELLALLLEePPEGAGHWTLRELAALLEEE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  63 -GWQVNHKRVARIWRREGLKV-----VPHKQKKRGRLWLDDGSCVRLKPEHPNHVWSYD---FVQD-------------- 119
Cdd:NF033545   92 fGVEYSRSTVRRLLKRLGLSPkkprpRAPKQDPEFVEKFKEVLGLYRAPPDPAEVVFIDesgIQLLdtrgrgwapkgqrr 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115 120 -RTSDGRTYRTLNIL--DEYTREALMIRVDRRLNSTDVLDALTDLFIQ-RGPPRFIRSDNGPEFIAQKVRDWIELVG-AK 194
Cdd:NF033545  172 pRVHVYGRRGTLNLFgaLDPLTGKVFVLFTGRINSEDFIEFLEELLAAyPGKKIHLILDNASTHKSKKVREWLEEHGrIE 251

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1044515115 195 TAYIEPGSPWENgYCESFNSRFRDELLNGEVFYSLREAQILIEQW 239
Cdd:NF033545  252 LHYLPPYSPWLN-PIERVWAVLKRRLLRNRAFRSVDELREAIDAF 295
HAD-SF-IIIA TIGR01662
HAD-superfamily hydrolase, subfamily IIIA; This subfamily falls within the Haloacid ...
 22-96 1.25e-03

HAD-superfamily hydrolase, subfamily IIIA; This subfamily falls within the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The Class III subfamilies are characterized by the lack of any domains located between either between the first and second conserved catalytic motifs (as in the Class I subfamilies, TIGR01493, TIGR01509, TIGR01488 and TIGR01494) or between the second and third conserved catalytic motifs (as in the Class II subfamilies, TIGR01460 and TIGR01484) of the superfamily domain. The IIIA subfamily contains five major clades: histidinol-phosphatase (TIGR01261) and histidinol-phosphatase-related protein (TIGR00213) which together form a subfamily (TIGR01656), DNA 3'-phosphatase (TIGR01663, TIGR01664), YqeG (TIGR01668) and YrbI (TIGR01670). In the case of histidinol phosphatase and PNK-3'-phosphatase, this model represents a domain of a bifunctional system. In the histidinol phosphatase HisB, a C-terminal domain is an imidazoleglycerol-phosphate dehydratase which catalyzes a related step in histidine biosynthesis. In PNK-3'-phosphatase, N- and C-terminal domains constitute the polynucleotide kinase and DNA-binding components of the enzyme. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273742 [Multi-domain]  Cd Length: 135  Bit Score: 38.15  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044515115  22 TQRKPPQGREDEARLTADVIDLAREYGRYGYrRVAVL------LRRAGWQVNHKRVARIWRREGLKV-----VPHKQKKR 90
Cdd:TIGR01662  12 TDDVPYVSDEDERILYPEVPDALAELKEAGY-KVVIVtnqsgiGRGYFSRSFSGRVARRLEELGVPIdilyaCPGCRKPK 90


                  ....*.
gi 1044515115  91 GRLWLD 96
Cdd:TIGR01662  91 PGMFLE 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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