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Conserved domains on  [gi|1047842901|gb|ANW66662|]
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hypothetical protein BCA37_26585 [Mycobacterium sp. djl-10]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rv0340_fam NF038176
Rv0340 family protein; Homologs of Rv0340 from Mycobacterium tuberculosis H37Rv are regularly ...
 1-163 4.07e-50

Rv0340 family protein; Homologs of Rv0340 from Mycobacterium tuberculosis H37Rv are regularly found encoded upstream of the genes for IniB, IniA, and IniC. As with those families, mutation in this family can contribute to resistance to isoniazid, a front-line treatment for Mycobacterium tuberculosis that works by inhibiting cell wall biosynthesis. Rv0340 and glycine-rich repetive protein IniB are homologous across the N-terminal 50 amino acids of each, but otherwise dissimilar.


:

Pssm-ID: 468397  Cd Length: 179  Bit Score: 158.97  E-value: 4.07e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047842901   1 MANELLDFVMDLVRDPDAAARYAADPSQAIADAHLTNVTSADVNNLIPMVSDSLSMAAPAFGADAGLDDTLDGNVWTSG- 79
Cdd:NF038176    1 MANSLLDFVMSLVRDPDAAARYAADPAQAIADAHLTDVTSADVNNLIPVVSESLSMAAPAGGADAGAPAADHGNVWASGa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047842901  80 ---------AATAAFDAFAPLTTEHITDIPTVVDTAGPEVASVVPDFEPLVDTVLADDPALGDAPADPA------PALWE 144
Cdd:NF038176   81 ataafdafdDHVPAAVVDQHGPVGGVIDQPAAPAPDDAPADPQPLGVDLHDPSVQLTGPEIDDPAVDHGafpaddPADWD 160

                         170
                  ....*....|....*....
gi 1047842901 145 GPATDPQPLDEGHHTFDLF 163
Cdd:NF038176  161 HPVIDDHDLDPDHHGFDIF 179
 
Name Accession Description Interval E-value
Rv0340_fam NF038176
Rv0340 family protein; Homologs of Rv0340 from Mycobacterium tuberculosis H37Rv are regularly ...
 1-163 4.07e-50

Rv0340 family protein; Homologs of Rv0340 from Mycobacterium tuberculosis H37Rv are regularly found encoded upstream of the genes for IniB, IniA, and IniC. As with those families, mutation in this family can contribute to resistance to isoniazid, a front-line treatment for Mycobacterium tuberculosis that works by inhibiting cell wall biosynthesis. Rv0340 and glycine-rich repetive protein IniB are homologous across the N-terminal 50 amino acids of each, but otherwise dissimilar.


Pssm-ID: 468397  Cd Length: 179  Bit Score: 158.97  E-value: 4.07e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047842901   1 MANELLDFVMDLVRDPDAAARYAADPSQAIADAHLTNVTSADVNNLIPMVSDSLSMAAPAFGADAGLDDTLDGNVWTSG- 79
Cdd:NF038176    1 MANSLLDFVMSLVRDPDAAARYAADPAQAIADAHLTDVTSADVNNLIPVVSESLSMAAPAGGADAGAPAADHGNVWASGa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047842901  80 ---------AATAAFDAFAPLTTEHITDIPTVVDTAGPEVASVVPDFEPLVDTVLADDPALGDAPADPA------PALWE 144
Cdd:NF038176   81 ataafdafdDHVPAAVVDQHGPVGGVIDQPAAPAPDDAPADPQPLGVDLHDPSVQLTGPEIDDPAVDHGafpaddPADWD 160

                         170
                  ....*....|....*....
gi 1047842901 145 GPATDPQPLDEGHHTFDLF 163
Cdd:NF038176  161 HPVIDDHDLDPDHHGFDIF 179
IniB_NTERM NF038175
IniB N-terminal domain; This domain is found as the N-terminal fifty amino acids of a number ...
 5-52 9.67e-15

IniB N-terminal domain; This domain is found as the N-terminal fifty amino acids of a number low-complexity proteins that often bear little or no similarity to each other elsewhere in the protein. The domain occurs twice in Mycobacterium tuberculosis strain H37Rv, in two adjacent proteins, Rv0340 and the isoniazid inducible protein IniB (Rv0341).


Pssm-ID: 439489 [Multi-domain]  Cd Length: 49  Bit Score: 64.53  E-value: 9.67e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1047842901   5 LLDFVMDLVRDPDAAARYAADPSQAIADAHLTNVTSADVNNLIPMVSD 52
Cdd:NF038175    2 LIDFILSLFRDPDAAAAFVADPEAALAAAGLGDVTAADVQAVAPLVAD 49
Extradiol_Dioxygenase_3A_like cd07321
Subunit A of Class III extradiol dioxygenases; Extradiol dioxygenases catalyze the ...
 1-58 4.47e-03

Subunit A of Class III extradiol dioxygenases; Extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into substrates using a variety of reaction mechanisms, resulting in the cleavage of aromatic rings. There are two major groups of dioxygenases according to the cleavage site of the aromatic ring. Intradiol enzymes cleave the aromatic ring between two hydroxyl groups, whereas extradiol enzymes cleave the aromatic ring between a hydroxylated carbon and an adjacent non-hydroxylated carbon. Extradiol dioxygenases can be divided into three classes. Class I and II enzymes are evolutionary related and show sequence similarity, with the two domain class II enzymes evolving from the class I enzyme through gene duplication. Class III enzymes are different in sequence and structure and usually have two subunits, designated A and B, which form a tetramer composed of two copies of each subunit. This model represents subunit A of class III extradiol dioxygenase enzymes. The A subunit is the smaller, non-catalytic subunit. Enzymes that belong to this family include Protocatechuate 4,5-dioxygenase (LigAB) A subunit, 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase (CarB) A subunit, Gallate Dioxygenase and proteins of unknown function.


Pssm-ID: 153390 [Multi-domain]  Cd Length: 77  Bit Score: 34.21  E-value: 4.47e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1047842901   1 MANELLDFVMDLVRDPDAAARYAADPSQAIADAHLTN-----VTSADVNNLIPM-VSDSLSMAA 58
Cdd:cd07321     1 SRYELEKLLEQLLVKPEVKERFKADPEAVLAEYGLTPeekaaLLARDVGALYVLgVNPMLLMHF 64
 
Name Accession Description Interval E-value
Rv0340_fam NF038176
Rv0340 family protein; Homologs of Rv0340 from Mycobacterium tuberculosis H37Rv are regularly ...
 1-163 4.07e-50

Rv0340 family protein; Homologs of Rv0340 from Mycobacterium tuberculosis H37Rv are regularly found encoded upstream of the genes for IniB, IniA, and IniC. As with those families, mutation in this family can contribute to resistance to isoniazid, a front-line treatment for Mycobacterium tuberculosis that works by inhibiting cell wall biosynthesis. Rv0340 and glycine-rich repetive protein IniB are homologous across the N-terminal 50 amino acids of each, but otherwise dissimilar.


Pssm-ID: 468397  Cd Length: 179  Bit Score: 158.97  E-value: 4.07e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047842901   1 MANELLDFVMDLVRDPDAAARYAADPSQAIADAHLTNVTSADVNNLIPMVSDSLSMAAPAFGADAGLDDTLDGNVWTSG- 79
Cdd:NF038176    1 MANSLLDFVMSLVRDPDAAARYAADPAQAIADAHLTDVTSADVNNLIPVVSESLSMAAPAGGADAGAPAADHGNVWASGa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047842901  80 ---------AATAAFDAFAPLTTEHITDIPTVVDTAGPEVASVVPDFEPLVDTVLADDPALGDAPADPA------PALWE 144
Cdd:NF038176   81 ataafdafdDHVPAAVVDQHGPVGGVIDQPAAPAPDDAPADPQPLGVDLHDPSVQLTGPEIDDPAVDHGafpaddPADWD 160

                         170
                  ....*....|....*....
gi 1047842901 145 GPATDPQPLDEGHHTFDLF 163
Cdd:NF038176  161 HPVIDDHDLDPDHHGFDIF 179
IniB_NTERM NF038175
IniB N-terminal domain; This domain is found as the N-terminal fifty amino acids of a number ...
 5-52 9.67e-15

IniB N-terminal domain; This domain is found as the N-terminal fifty amino acids of a number low-complexity proteins that often bear little or no similarity to each other elsewhere in the protein. The domain occurs twice in Mycobacterium tuberculosis strain H37Rv, in two adjacent proteins, Rv0340 and the isoniazid inducible protein IniB (Rv0341).


Pssm-ID: 439489 [Multi-domain]  Cd Length: 49  Bit Score: 64.53  E-value: 9.67e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1047842901   5 LLDFVMDLVRDPDAAARYAADPSQAIADAHLTNVTSADVNNLIPMVSD 52
Cdd:NF038175    2 LIDFILSLFRDPDAAAAFVADPEAALAAAGLGDVTAADVQAVAPLVAD 49
Extradiol_Dioxygenase_3A_like cd07321
Subunit A of Class III extradiol dioxygenases; Extradiol dioxygenases catalyze the ...
 1-58 4.47e-03

Subunit A of Class III extradiol dioxygenases; Extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into substrates using a variety of reaction mechanisms, resulting in the cleavage of aromatic rings. There are two major groups of dioxygenases according to the cleavage site of the aromatic ring. Intradiol enzymes cleave the aromatic ring between two hydroxyl groups, whereas extradiol enzymes cleave the aromatic ring between a hydroxylated carbon and an adjacent non-hydroxylated carbon. Extradiol dioxygenases can be divided into three classes. Class I and II enzymes are evolutionary related and show sequence similarity, with the two domain class II enzymes evolving from the class I enzyme through gene duplication. Class III enzymes are different in sequence and structure and usually have two subunits, designated A and B, which form a tetramer composed of two copies of each subunit. This model represents subunit A of class III extradiol dioxygenase enzymes. The A subunit is the smaller, non-catalytic subunit. Enzymes that belong to this family include Protocatechuate 4,5-dioxygenase (LigAB) A subunit, 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase (CarB) A subunit, Gallate Dioxygenase and proteins of unknown function.


Pssm-ID: 153390 [Multi-domain]  Cd Length: 77  Bit Score: 34.21  E-value: 4.47e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1047842901   1 MANELLDFVMDLVRDPDAAARYAADPSQAIADAHLTN-----VTSADVNNLIPM-VSDSLSMAA 58
Cdd:cd07321     1 SRYELEKLLEQLLVKPEVKERFKADPEAVLAEYGLTPeekaaLLARDVGALYVLgVNPMLLMHF 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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