NCBI Conserved Domain Search

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...

261-737

0e+00

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 597.73 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 261 EKRLMELKLFKSEERFREIFENAMDAIVIWSDDGKIAKANESACRIFELPMDKLLETNLCTFIVDPQKKYKQIKKKYEKY 340
Cdd:COG5809     2 KSSKMELQLRKSEQRFRSLFENAPDAILILDLEGKILKVNPAAERIFGYTEDELLGTNILDFLHPDDEKELREILKLLKE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 341 GEIREEMLFQMANGQYKELEFTSKRTILEGQH------LTILRNVSDRKRMEKELRESELKFRKVFNGSMDGKVLFDNQF 414
Cdd:COG5809    82 GESRDELEFELRHKNGKRLEFSSKLSPIFDQNgdiegmLAISRDITERKRMEEALRESEEKFRLIFNHSPDGIIVTDLDG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 415 RIIDANPLASRILGMPDEELRAYTVPDILSLFDIENAGVPARKIDLEG--MDNEIPFLLSSSDSRKLEFSF---KRNIIQ 489
Cdd:COG5809   162 RIIYANPAACKLLGISIEELIGKSILELIHSDDQENVAAFISQLLKDGgiAQGEVRFWTKDGRWRLLEASGapiKKNGEV 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 490 NMNLAIFKDVTEAKELEERLRKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLQGSIEGEYSLYFNVITSELKRIESII 569
Cdd:COG5809   242 DGIVIIFRDITERKKLEELLRKSEKLSVVGELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTYLDIMLSELDRIESII 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 570 TEFLILAKPQAILYEEKDVTQIMKDTADLLNAQANLVNVQIHLNLTGNIPPIYCEPNQLKQVFINILKNAIEVMPGGGNI 649
Cdd:COG5809   322 SEFLVLAKPQAIKYEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNI 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 650 YVTIQPSDQDHILISFQDEGTGISEDKLKRLGEPFYTTKDRGTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPIR 729
Cdd:COG5809   402 TIETKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIK 481


                  ....*...
gi 1101469627 730 QNTEERRS 737
Cdd:COG5809   482 LSEQVSMN 489

KinE super family

cl47428

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...

26-273

8.17e-32

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

The actual alignment was detected with superfamily member COG5809:

Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 130.09 E-value: 8.17e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  26 RLKSDLNRYHVIMNNTLDAIFICRKEMKIVQANEAAARMMQIEAESLINRSVLDFLYSVPQEELnKAVKKFLKKGHLWKE 105
Cdd:COG5809     9 QLRKSEQRFRSLFENAPDAILILDLEGKILKVNPAAERIFGYTEDELLGTNILDFLHPDDEKEL-REILKLLKEGESRDE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 106 VPIKLDSGATKYIEFLAR-----DGIGE-DYFFVVMRDISSKKILEREFSMNEQLFKDLFDRAVDGIVLFDKDGGFIDAN 179
Cdd:COG5809    88 LEFELRHKNGKRLEFSSKlspifDQNGDiEGMLAISRDITERKRMEEALRESEEKFRLIFNHSPDGIIVTDLDGRIIYAN 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 180 LSFCKSFEIGQNELSHLSLRHFTDGENKKHLKE-IWETLRRKGNAKGELPVKLRSGEEKLFEF---TITSNLISGFYMSI 255
Cdd:COG5809   168 PAACKLLGISIEELIGKSILELIHSDDQENVAAfISQLLKDGGIAQGEVRFWTKDGRWRLLEAsgaPIKKNGEVDGIVII 247

                         250
                  ....*....|....*...
gi 1101469627 256 MRDITEKRLMELKLFKSE 273
Cdd:COG5809   248 FRDITERKKLEELLRKSE 265

Name

Accession

Description

Interval

E-value

KinE

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...

261-737

0e+00

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 597.73 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 261 EKRLMELKLFKSEERFREIFENAMDAIVIWSDDGKIAKANESACRIFELPMDKLLETNLCTFIVDPQKKYKQIKKKYEKY 340
Cdd:COG5809     2 KSSKMELQLRKSEQRFRSLFENAPDAILILDLEGKILKVNPAAERIFGYTEDELLGTNILDFLHPDDEKELREILKLLKE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 341 GEIREEMLFQMANGQYKELEFTSKRTILEGQH------LTILRNVSDRKRMEKELRESELKFRKVFNGSMDGKVLFDNQF 414
Cdd:COG5809    82 GESRDELEFELRHKNGKRLEFSSKLSPIFDQNgdiegmLAISRDITERKRMEEALRESEEKFRLIFNHSPDGIIVTDLDG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 415 RIIDANPLASRILGMPDEELRAYTVPDILSLFDIENAGVPARKIDLEG--MDNEIPFLLSSSDSRKLEFSF---KRNIIQ 489
Cdd:COG5809   162 RIIYANPAACKLLGISIEELIGKSILELIHSDDQENVAAFISQLLKDGgiAQGEVRFWTKDGRWRLLEASGapiKKNGEV 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 490 NMNLAIFKDVTEAKELEERLRKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLQGSIEGEYSLYFNVITSELKRIESII 569
Cdd:COG5809   242 DGIVIIFRDITERKKLEELLRKSEKLSVVGELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTYLDIMLSELDRIESII 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 570 TEFLILAKPQAILYEEKDVTQIMKDTADLLNAQANLVNVQIHLNLTGNIPPIYCEPNQLKQVFINILKNAIEVMPGGGNI 649
Cdd:COG5809   322 SEFLVLAKPQAIKYEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNI 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 650 YVTIQPSDQDHILISFQDEGTGISEDKLKRLGEPFYTTKDRGTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPIR 729
Cdd:COG5809   402 TIETKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIK 481


                  ....*...
gi 1101469627 730 QNTEERRS 737
Cdd:COG5809   482 LSEQVSMN 489

PRK11360

two-component system sensor histidine kinase AtoS;

384-729

3.37e-76

two-component system sensor histidine kinase AtoS;

Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 257.20 E-value: 3.37e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 384 RMEKELRESELKFRKVFNGSMDGKVLFDNQFRIIDANPLASRILGMPDEEL--RAYT--------VPDILSLFDIENAGV 453
Cdd:PRK11360  252 NLAQALRETRSLNELILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELvgKPYSelfppntpFASPLLDTLEHGTEH 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 454 PARKIDLEGMDNEIPFLLSSSdsrkLEFSFKRNIIQNmnLAIFKDVTEAKELEERLRKSDTLHVVGELAAGIAHEIRNPM 533
Cdd:PRK11360  332 VDLEISFPGRDRTIELSVSTS----LLHNTHGEMIGA--LVIFSDLTERKRLQRRVARQERLAALGELVAGVAHEIRNPL 405

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 534 TALKGFIQLLQGSIEG-EYSLYFNVITSELKRIESIITEFLILAKPQAILYEEKDVTQIMKDTADLLNAQANLVNVQIHL 612
Cdd:PRK11360  406 TAIRGYVQIWRQQTSDpPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEEVLQLFQTAGVQARVDFET 485

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 613 NLTGNIPPIYCEPNQLKQVFINILKNAIEVMPGGGNIYVTIQPSDQDHILISFQDEGTGISEDKLKRLGEPFYTTKDRGT 692
Cdd:PRK11360  486 ELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGT 565

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1101469627 693 GLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPIR 729
Cdd:PRK11360  566 GLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPIN 602

HATPase_AtoS-like

cd16943

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

625-728

7.56e-33

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.

Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 122.15 E-value: 7.56e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 625 PNQLKQVFINILKNAIEVMPGGGNIYVTIQPSDqDHILISFQDEGTGISEDKLKRLGEPFYTTKD--RGTGLGLMVSYKI 702
Cdd:cd16943     1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHV-DQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvgEGTGLGLSLSYRI 79

                          90       100
                  ....*....|....*....|....*.
gi 1101469627 703 IEEHQGRIHVESEEGKGTVFHLTLPI 728
Cdd:cd16943    80 IQKHGGTIRVASVPGGGTRFTIILPI 105

KinE

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...

26-273

8.17e-32

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 130.09 E-value: 8.17e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  26 RLKSDLNRYHVIMNNTLDAIFICRKEMKIVQANEAAARMMQIEAESLINRSVLDFLYSVPQEELnKAVKKFLKKGHLWKE 105
Cdd:COG5809     9 QLRKSEQRFRSLFENAPDAILILDLEGKILKVNPAAERIFGYTEDELLGTNILDFLHPDDEKEL-REILKLLKEGESRDE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 106 VPIKLDSGATKYIEFLAR-----DGIGE-DYFFVVMRDISSKKILEREFSMNEQLFKDLFDRAVDGIVLFDKDGGFIDAN 179
Cdd:COG5809    88 LEFELRHKNGKRLEFSSKlspifDQNGDiEGMLAISRDITERKRMEEALRESEEKFRLIFNHSPDGIIVTDLDGRIIYAN 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 180 LSFCKSFEIGQNELSHLSLRHFTDGENKKHLKE-IWETLRRKGNAKGELPVKLRSGEEKLFEF---TITSNLISGFYMSI 255
Cdd:COG5809   168 PAACKLLGISIEELIGKSILELIHSDDQENVAAfISQLLKDGGIAQGEVRFWTKDGRWRLLEAsgaPIKKNGEVDGIVII 247

                         250
                  ....*....|....*...
gi 1101469627 256 MRDITEKRLMELKLFKSE 273
Cdd:COG5809   248 FRDITERKKLEELLRKSE 265

HATPase_c

smart00387

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

625-729

8.80e-32

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 119.29 E-value: 8.80e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  625 PNQLKQVFINILKNAIEVMPGGGNIYVTIQPsDQDHILISFQDEGTGISEDKLKRLGEPFYTTKDR-----GTGLGLMVS 699
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEGGRITVTLER-DGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkigGTGLGLSIV 81

                           90       100       110
                   ....*....|....*....|....*....|
gi 1101469627  700 YKIIEEHQGRIHVESEEGKGTVFHLTLPIR 729
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGTTFTITLPLE 111

HATPase_c

pfam02518

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...

625-730

2.15e-30

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 115.54 E-value: 2.15e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 625 PNQLKQVFINILKNAIEVMPGGGNIYVTIqpSDQDHILISFQDEGTGISEDKLKRLGEPFYTTKDR---GTGLGLMVSYK 701
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAAKAGEITVTL--SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRgggGTGLGLSIVRK 80

                          90       100
                  ....*....|....*....|....*....
gi 1101469627 702 IIEEHQGRIHVESEEGKGTVFHLTLPIRQ 730
Cdd:pfam02518  81 LVELLGGTITVESEPGGGTTVTLTLPLAQ 109

sensory_box

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...

272-389

2.54e-09

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]

Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 55.76 E-value: 2.54e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 272 SEERFREIFENAMDAIVIWSDDGKIAKANESACRIFELPMDKLLETNLCTFIVDPQKKYKQIKKKYEKYGEI---REEML 348
Cdd:TIGR00229   1 SEERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEEDREEVRERIERRLEGEPepvSEERR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1101469627 349 FQMANGQYKELEFTSKRTILEGQH---LTILRNVSDRKRMEKEL 389
Cdd:TIGR00229  81 VRRKDGSEIWVEVSVSPIRTNGGElgvVGIVRDITERKEAEEAL 124

PAS_4

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...

43-139

3.12e-07

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 49.33 E-value: 3.12e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  43 DAIFICRKEMKIVQANEAAARMMQIEAESLINRSVLDFLYSVPQEELNKAVKKFLKKGHLWKEVPIKLDSGATKYIEFLA 122
Cdd:pfam08448   6 DALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPEDAARLERALRRALEGEEPIDFLEELLLNGEERHYELRL 85

                          90       100
                  ....*....|....*....|.
gi 1101469627 123 ---RDGIGE-DYFFVVMRDIS 139
Cdd:pfam08448  86 tplRDPDGEvIGVLVISRDIT 106

sensory_box

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...

152-269

5.25e-07

Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 49.21 E-value: 5.25e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 152 EQLFKDLFDRAVDGIVLFDKDGGFIDANLSFCKSFEIGQNELSHLSLRHFTDGENKKHLKE-IWETLRRKGNAKGELPVK 230
Cdd:TIGR00229   2 EERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEEDREEVRErIERRLEGEPEPVSEERRV 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1101469627 231 LRS-GEEKLFEFTITSNLISG---FYMSIMRDITEKRLMELKL 269
Cdd:TIGR00229  82 RRKdGSEIWVEVSVSPIRTNGgelGVVGIVRDITERKEAEEAL 124

PAS

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

33-95

3.51e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.

Pssm-ID: 214512 Cd Length: 67 Bit Score: 39.30 E-value: 3.51e-04

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1101469627   33 RYHVIMNNTLDAIFICRKEMKIVQANEAAARMMQIEAESLINRSVLDFLYSVPQEELNKAVKK 95
Cdd:smart00091   2 RLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQR 64

PAS

cd00130

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

43-138

3.58e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.

Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 40.31 E-value: 3.58e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  43 DAIFICRKEMKIVQANEAAARMMQIEAESLINRSVLDFLYSVPQEELNKAVKKFLKKGHLWK-EVPIKLDSGATKYIEF- 120
Cdd:cd00130     3 DGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTlEVRLRRKDGSVIWVLVs 82

                          90       100
                  ....*....|....*....|.
gi 1101469627 121 ---LARDGIGEDYFFVVMRDI 138
Cdd:cd00130    83 ltpIRDEGGEVIGLLGVVRDI 103

PRK13560

hypothetical protein; Provisional

11-173

7.98e-04

hypothetical protein; Provisional

Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 42.74 E-value: 7.98e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  11 ESLKEQLKRMKEENDRLKSDLNRYHVIMNNTLDAIFICRKEMKIVQANEAAARMMQIEAESLINRSVLDFLYSVPQEELN 90
Cdd:PRK13560  183 DGFAEDITERKRAEERIDEALHFLQQLLDNIADPAFWKDEDAKVFGCNDAACLACGFRREEIIGMSIHDFAPAQPADDYQ 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  91 KA-VKKFLKKGHLWKEVPIKLDSGATKYIE--FLARDGIGEDY----FFVVMRDISSKKILEREFSMNEQLFKDLFDRAV 163
Cdd:PRK13560  263 EAdAAKFDADGSQIIEAEFQNKDGRTRPVDviFNHAEFDDKENhcagLVGAITDISGRRAAERELLEKEDMLRAIIEAAP 342

                         170
                  ....*....|
gi 1101469627 164 DGIVLFDKDG 173
Cdd:PRK13560  343 IAAIGLDADG 352

Name

Accession

Description

Interval

E-value

KinE

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...

261-737

0e+00

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 597.73 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 261 EKRLMELKLFKSEERFREIFENAMDAIVIWSDDGKIAKANESACRIFELPMDKLLETNLCTFIVDPQKKYKQIKKKYEKY 340
Cdd:COG5809     2 KSSKMELQLRKSEQRFRSLFENAPDAILILDLEGKILKVNPAAERIFGYTEDELLGTNILDFLHPDDEKELREILKLLKE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 341 GEIREEMLFQMANGQYKELEFTSKRTILEGQH------LTILRNVSDRKRMEKELRESELKFRKVFNGSMDGKVLFDNQF 414
Cdd:COG5809    82 GESRDELEFELRHKNGKRLEFSSKLSPIFDQNgdiegmLAISRDITERKRMEEALRESEEKFRLIFNHSPDGIIVTDLDG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 415 RIIDANPLASRILGMPDEELRAYTVPDILSLFDIENAGVPARKIDLEG--MDNEIPFLLSSSDSRKLEFSF---KRNIIQ 489
Cdd:COG5809   162 RIIYANPAACKLLGISIEELIGKSILELIHSDDQENVAAFISQLLKDGgiAQGEVRFWTKDGRWRLLEASGapiKKNGEV 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 490 NMNLAIFKDVTEAKELEERLRKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLQGSIEGEYSLYFNVITSELKRIESII 569
Cdd:COG5809   242 DGIVIIFRDITERKKLEELLRKSEKLSVVGELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTYLDIMLSELDRIESII 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 570 TEFLILAKPQAILYEEKDVTQIMKDTADLLNAQANLVNVQIHLNLTGNIPPIYCEPNQLKQVFINILKNAIEVMPGGGNI 649
Cdd:COG5809   322 SEFLVLAKPQAIKYEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNI 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 650 YVTIQPSDQDHILISFQDEGTGISEDKLKRLGEPFYTTKDRGTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPIR 729
Cdd:COG5809   402 TIETKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIK 481


                  ....*...
gi 1101469627 730 QNTEERRS 737
Cdd:COG5809   482 LSEQVSMN 489

KinA

COG5805

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...

273-728

1.50e-126

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 386.01 E-value: 1.50e-126

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 273 EERFREIFENAMDAIVIWSDDGKIAKANESACRIFELPMDKLLETNLCTFIvDPQKKYKQIKKKYEKYGEIREEMLFQM- 351
Cdd:COG5805    33 TEELETILENLPDAIIAVNREGKVIYINPAMEKLLGYTSEEIIGKTIFDFL-EKEYHYRVKTRIERLQKGYDVVMIEQIy 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 352 -ANGQYKELEFTSKRTILEGQHLTIL--RNVSDRKRMEKELRESELKFRKVFNGSMDGKVLFDNQFRIIDANPLASRILG 428
Cdd:COG5805   112 cKDGELIYVEVKLFPIYNQNGQAAILalRDITKKKKIEEILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFG 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 429 MPDEELRAYTVPDILSLFD----------IENAGVPaRKIDLEGMDNE---IPFLLSSSDSRKLEFSFKRNIIqnmnlaI 495
Cdd:COG5805   192 APREELIGKNLLELLHPCDkeefkeriesITEVWQE-FIIEREIITKDgriRYFEAVIVPLIDTDGSVKGILV------I 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 496 FKDVTEAKELEERLRKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLQGSIEgEYSLYFNVITSELKRIESIITEFLIL 575
Cdd:COG5805   265 LRDITEKKEAEELMARSEKLSIAGQLAAGIAHEIRNPLTSIKGFLQLLQPGIE-DKEEYFDIMLSELDRIESIISEFLAL 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 576 AKPQAILYEEKDVTQIMKDTADLLNAQANLVNVQIHLNLTGNIPPIYCEPNQLKQVFINILKNAIEVMPGGGNIYVTIQP 655
Cdd:COG5805   344 AKPQAVNKEKENINELIQDVVTLLETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEE 423

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1101469627 656 SDQDhILISFQDEGTGISEDKLKRLGEPFYTTKDRGTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPI 728
Cdd:COG5805   424 EDNS-VIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495

NtrB

COG3852

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

388-734

2.35e-97

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 305.23 E-value: 2.35e-97

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 388 ELRESELKFRKVFNGSMDGKVLFDNQFRIIDANPLASRILGMPDEELRAYTVPDILSLFDI----------ENAGVPARK 457
Cdd:COG3852     1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPlrelleralaEGQPVTERE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 458 IDLEGMDNE-IPFLLSSSdsrklefSFKRNIIQNMNLAIFKDVTEAKELEERLRKSDTLHVVGELAAGIAHEIRNPMTAL 536
Cdd:COG3852    81 VTLRRKDGEeRPVDVSVS-------PLRDAEGEGGVLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGI 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 537 KGFIQLLQGSI-EGEYSLYFNVITSELKRIESIITEFLILAKPQAILYEEKDVTQIMKDTADLLNAQANlVNVQIHLNLT 615
Cdd:COG3852   154 RGAAQLLERELpDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPEREPVNLHEVLERVLELLRAEAP-KNIRIVRDYD 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 616 GNIPPIYCEPNQLKQVFINILKNAIEVMPGGGNIYVTIQPSDQ---------DHILISFQDEGTGISEDKLKRLGEPFYT 686
Cdd:COG3852   233 PSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQvtlgglrprLYVRIEVIDNGPGIPEEILDRIFEPFFT 312

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1101469627 687 TKDRGTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPIRQNTEE 734
Cdd:COG3852   313 TKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEEE 360

KinC

COG5807

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ...

371-729

1.92e-93

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 295.16 E-value: 1.92e-93

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 371 QHLTILRNVSDRKRMEKELRESELKFRKVFNGSMDGKVLFDNQFRIIDANPLASRILGMPDEELRAYTVP---DILSLFD 447
Cdd:COG5807     4 QRATDFYHIEEKNQEFKLTEDSEFKFKQLFDSILEFVFFIDSKGEILECNDFAEDLYGLSQNEYIGKTFVeekCILKDEQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 448 IENAGVPARkidlegmdNEIPFLLSSSDSRKLEFS-FKRNIIQNMNLAIFKDVTEAKELEERLRKSDTLHVVGELAAGIA 526
Cdd:COG5807    84 LYNKEAFDR--------IEISYLTKNGEFDEIIYPiYYKDGVILGLITVYRDITKRKEAEDKLLRSEKLSVAGELAAGIA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 527 HEIRNPMTALKGFIQLLQGSIEG-EYSLYFNVITSELKRIESIITEFLILAKPQAILYEEKDVTQIMKDTADLLNAQANL 605
Cdd:COG5807   156 HEIRNPLTSIKGFLQLLQESREDsEREEYFNIIISEIDRINTIITELLVLSKPKKFNFKKLNLNDVLEDVIALLSTEAIL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 606 VNVQIHLNLTGNIPPIYCEPNQLKQVFINILKNAIEVMPGGGNIyvTIQPSDQ-DHILISFQDEGTGISEDKLKRLGEPF 684
Cdd:COG5807   236 KNISIKYDLADDEPVINGDKNQLKQVFINLIKNAIEAMETGGNI--TIKTYVEgDFVVISVKDEGIGIPEEVLEKIGEPF 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1101469627 685 YTTKDRGTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPIR 729
Cdd:COG5807   314 FTTKEEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLPLY 358

NtrY

COG5000

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...

383-733

1.55e-83

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];

Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 271.45 E-value: 1.55e-83

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 383 KRMEKELRESELKFRKVFNGSMDGKVLFDNQFRIIDANPLASRILGMPDEELRAYTVPDILSLFDIENAGVPARKidlEG 462
Cdd:COG5000    79 KEQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAELLREALE---RG 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 463 MDNEIPflLSSSDSRKLEFSFKRnIIQNMNLAIFKDVTEAKElEERLRksdtlhVVGELAAGIAHEIRNPMTALKGFIQL 542
Cdd:COG5000   156 WQEEIE--LTRDGRRTLLVRASP-LRDDGYVIVFDDITELLR-AERLA------AWGELARRIAHEIKNPLTPIQLSAER 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 543 LQ-------GSIEGEYSLYFNVITSELKRIESIITEFLILAKPQAILYEEKDVTQIMKDTADLLNAQANLVNVQIHLNLT 615
Cdd:COG5000   226 LRrkladklEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQLEPVDLNELLREVLALYEPALKEKDIRLELDLD 305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 616 GNIPPIYCEPNQLKQVFINILKNAIEVMPGGGNIYVTIQPsDQDHILISFQDEGTGISEDKLKRLGEPFYTTKDRGTGLG 695
Cdd:COG5000   306 PDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRR-EDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLG 384

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1101469627 696 LMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPIRQNTE 733
Cdd:COG5000   385 LAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422

KinB

COG5806

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...

487-727

2.36e-78

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 257.10 E-value: 2.36e-78

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 487 IIQNMNlaifkdvtEAKELEERLRKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLQGSIEGEYSL--YFNVITSELKR 564
Cdd:COG5806   178 LIENLI--------ENILLRKELQRAEKLEVVSELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKRkqYIRIALEELDR 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 565 IESIITEFLILAKPQAILYEEKDVTQIMKDTADLLNAQANLVNVQIHLNLTGNIPpIYCEPNQLKQVFINILKNAIEVMP 644
Cdd:COG5806   250 AEAIITDYLTFAKPQPEKLEKIDVSEELEHVIDVLSPYANMNNVEIQTELEPGLY-IEGDRQKLQQCLINIIKNGIEAMP 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 645 GGGNIYVTIQpSDQDHILISFQDEGTGISEDKLKRLGEPFYTTKDRGTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHL 724
Cdd:COG5806   329 NGGTLTIDVS-IDKNKVIISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTI 407


                  ...
gi 1101469627 725 TLP 727
Cdd:COG5806   408 TLP 410

PRK11360

two-component system sensor histidine kinase AtoS;

384-729

3.37e-76

two-component system sensor histidine kinase AtoS;

Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 257.20 E-value: 3.37e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 384 RMEKELRESELKFRKVFNGSMDGKVLFDNQFRIIDANPLASRILGMPDEEL--RAYT--------VPDILSLFDIENAGV 453
Cdd:PRK11360  252 NLAQALRETRSLNELILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELvgKPYSelfppntpFASPLLDTLEHGTEH 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 454 PARKIDLEGMDNEIPFLLSSSdsrkLEFSFKRNIIQNmnLAIFKDVTEAKELEERLRKSDTLHVVGELAAGIAHEIRNPM 533
Cdd:PRK11360  332 VDLEISFPGRDRTIELSVSTS----LLHNTHGEMIGA--LVIFSDLTERKRLQRRVARQERLAALGELVAGVAHEIRNPL 405

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 534 TALKGFIQLLQGSIEG-EYSLYFNVITSELKRIESIITEFLILAKPQAILYEEKDVTQIMKDTADLLNAQANLVNVQIHL 612
Cdd:PRK11360  406 TAIRGYVQIWRQQTSDpPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEEVLQLFQTAGVQARVDFET 485

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 613 NLTGNIPPIYCEPNQLKQVFINILKNAIEVMPGGGNIYVTIQPSDQDHILISFQDEGTGISEDKLKRLGEPFYTTKDRGT 692
Cdd:PRK11360  486 ELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGT 565

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1101469627 693 GLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPIR 729
Cdd:PRK11360  566 GLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPIN 602

COG4191

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...

414-728

9.24e-71

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];

Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 235.46 E-value: 9.24e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 414 FRIIDANPLASRILGMPDEELRAYTVPDILSLFDIENAGVPARKIDLEGMDNEIPFLLSSSDSRKLEFSFKRNIIQNMNL 493
Cdd:COG4191    38 LLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDIT 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 494 AIFKDVTEAKELEERLRKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLQGSIEGEYSL-----YFNVITSELKRIESI 568
Cdd:COG4191   118 ELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLRRRLEDEPDPeelreALERILEGAERAAEI 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 569 ITEFLILAKPQAILYEEKDVTQIMKDTADLLNAQANLVNVQIHLNLTGNIPPIYCEPNQLKQVFINILKNAIEVMPGG-- 646
Cdd:COG4191   198 VRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGeg 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 647 GNIYVTIQPSDqDHILISFQDEGTGISEDKLKRLGEPFYTTKD--RGTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHL 724
Cdd:COG4191   278 GRITISTRREG-DYVVISVRDNGPGIPPEVLERIFEPFFTTKPvgKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTI 356


                  ....
gi 1101469627 725 TLPI 728
Cdd:COG4191   357 TLPL 360

KinD

COG5808

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...

503-730

2.36e-62

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 215.77 E-value: 2.36e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 503 KELEERLRK---SDTLHVVGELAAGIAHEIRNPMTALKGFIQLLQGSI-EGEYSLYFNVITSELKRIESIITEFLILAKP 578
Cdd:COG5808   223 KTLLERVIQeinTQKLELIGTFAASTAHEIRNPLTSIKGFIQLLQEKYpELEDQKYFDIIQEEIQRINQIVSEFLVLGKP 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 579 QAILYEEKDVTQIMKDTADLLNAQANLVNVQIHLNLTGNIPPIYCEPNQLKQVFINILKNAIEVMPGGGNIYVTIQPsDQ 658
Cdd:COG5808   303 TAKKLELDDLNELIEEILSIIDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKEGGKLTISIEN-DD 381

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1101469627 659 DHILISFQDEGTGISEDKLKRLGEPFYTTKDRGTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPIRQ 730
Cdd:COG5808   382 EKAVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLPLKK 453

BaeS

COG0642

Signal transduction histidine kinase [Signal transduction mechanisms];

408-729

8.10e-61

Signal transduction histidine kinase [Signal transduction mechanisms];

Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 207.84 E-value: 8.10e-61

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 408 VLFDNQFRIIDANPLASRILGMPDEELRAYTVPDILSLFDIENAGVPARKIDLEGMDNEIPFLLSSSDSRKLEFSFKRNI 487
Cdd:COG0642     9 VLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 488 IQNMNLAIFKDVTEAKELEERLRksdtlhvvgELAAGIAHEIRNPMTALKGFIQLLQGSIEGEYSLYFNVITSELKRIES 567
Cdd:COG0642    89 LLLLLLLLLALLLLLEEANEAKS---------RFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILRSADRLLR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 568 IITEFLILAKPQAILYEEK----DVTQIMKDTADLLNAQANLVNVQIHLNLTGNIPPIYCEPNQLKQVFINILKNAIEVM 643
Cdd:COG0642   160 LINDLLDLSRLEAGKLELEpepvDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 644 PGGGNIYVTIQPSDqDHILISFQDEGTGISEDKLKRLGEPFYTTKD----RGTGLGLMVSYKIIEEHQGRIHVESEEGKG 719
Cdd:COG0642   240 PEGGTVTVSVRREG-DRVRISVEDTGPGIPPEDLERIFEPFFRTDPsrrgGGTGLGLAIVKRIVELHGGTIEVESEPGKG 318

                         330
                  ....*....|
gi 1101469627 720 TVFHLTLPIR 729
Cdd:COG0642   319 TTFTVTLPLA 328

WalK

COG5002

Sensor histidine kinase WalK [Signal transduction mechanisms];

343-731

9.19e-56

Sensor histidine kinase WalK [Signal transduction mechanisms];

Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 195.93 E-value: 9.19e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 343 IREEMLFQMANGQYKELEFTSKRTILEGQHLTILRNVSDRKRMEKELRESELKFRKVFNGSMDGKVLFDNQFRIIDANPL 422
Cdd:COG5002     6 LLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 423 ASRILGMPDEELRAYTVPDILSLFDIENAGVPARkidlegmDNEIPFLLSSSDSRKLEFSFKRNIIQNMNLAIFKDVTEA 502
Cdd:COG5002    86 LALLLLLLLLLLLLALLILLLLLALLILLAALLL-------LLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITEL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 503 KELEERLRksdtlhvvgELAAGIAHEIRNPMTALKGFIQLLQGSIEG---EYSLYFNVITSELKRIESIITEFLILAKPQ 579
Cdd:COG5002   159 ERLEQMRR---------EFVANVSHELRTPLTSIRGYLELLLDGAADdpeERREYLEIILEEAERLSRLVNDLLDLSRLE 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 580 A----ILYEEKDVTQIMKDTADLLNAQANLVNVQIHLNLTGNIPPIYCEPNQLKQVFINILKNAIEVMPGGGNIYVTIQp 655
Cdd:COG5002   230 SgelkLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLR- 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 656 SDQDHILISFQDEGTGISEDKLKRLGEPFYTT-KDR-----GTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPIR 729
Cdd:COG5002   309 EEDDQVRISVRDTGIGIPEEDLPRIFERFYRVdKSRsretgGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLA 388


                  ..
gi 1101469627 730 QN 731
Cdd:COG5002   389 RE 390

KdpD

COG2205

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

501-731

2.05e-53

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 184.34 E-value: 2.05e-53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 501 EAKELEERLRKSDTLHvvGELAAGIAHEIRNPMTALKGFIQLLQ---GSIEGEYSLYFNVITSELKRIESIITEFLILAK 577
Cdd:COG2205     1 ELEEALEELEELERLK--SEFLANVSHELRTPLTSILGAAELLLdeeDLSPEERRELLEIIRESAERLLRLIEDLLDLSR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 578 PQA----ILYEEKDVTQIMKDTADLLNAQANLVNVQIHLNLTGNIPPIYCEPNQLKQVFINILKNAIEVMPGGGNIYVTI 653
Cdd:COG2205    79 LESgklsLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 654 QpSDQDHILISFQDEGTGISEDKLKRLGEPFYTTKD----RGTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPIR 729
Cdd:COG2205   159 R-REGDGVRISVSDNGPGIPEEELERIFERFYRGDNsrgeGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLA 237


                  ..
gi 1101469627 730 QN 731
Cdd:COG2205   238 ES 239

PRK10364

two-component system sensor histidine kinase ZraS;

503-737

1.95e-45

two-component system sensor histidine kinase ZraS;

Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 168.81 E-value: 1.95e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 503 KELEERLRKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLL--QGSIEGEYSLYFNVITSELKRIESIITEFLILAKPQA 580
Cdd:PRK10364  222 QLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFaeRAPAGGEAHQLAQVMAKEADRLNRVVSELLELVKPTH 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 581 ILYEEKDVTQIMKDTADLLNAQANLVNVQIHLNLTGNIPPIYCEPNQLKQVFINILKNAIEVMPGGGNIYVTIQPSDqDH 660
Cdd:PRK10364  302 LALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESG-AG 380

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1101469627 661 ILISFQDEGTGISEDKLKRLGEPFYTTKDRGTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPIrqNTEERRS 737
Cdd:PRK10364  381 VKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV--NITRRDP 455

PRK13837

two-component system VirA-like sensor kinase;

500-729

1.85e-34

two-component system VirA-like sensor kinase;

Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 140.97 E-value: 1.85e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 500 TEAKELEERLRKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLQ-----GSIEGEYSLYfnvITSELKRIESIITEFLI 574
Cdd:PRK13837  432 TERDALERRLEHARRLEAVGTLASGIAHNFNNILGAILGYAEMALnklarHSRAARYIDE---IISAGARARLIIDQILA 508

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 575 LAKPQAILYEEKDVTQIMKDTADLLNAqANLVNVQIHLNLTGNIPPIYCEPNQLKQVFINILKNAIEVMPGGGNiyVTIQ 654
Cdd:PRK13837  509 FGRKGERNTKPFDLSELVTEIAPLLRV-SLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGR--VDIS 585

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 655 PSDQ----------------DHILISFQDEGTGISEDKLKRLGEPFYTTKDRGTGLGLMVSYKIIEEHQGRIHVESEEGK 718
Cdd:PRK13837  586 LSRAklrapkvlshgvlppgRYVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGR 665

                         250
                  ....*....|.
gi 1101469627 719 GTVFHLTLPIR 729
Cdd:PRK13837  666 GTRFDVYLPPS 676

HATPase_AtoS-like

cd16943

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

625-728

7.56e-33

Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 122.15 E-value: 7.56e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 625 PNQLKQVFINILKNAIEVMPGGGNIYVTIQPSDqDHILISFQDEGTGISEDKLKRLGEPFYTTKD--RGTGLGLMVSYKI 702
Cdd:cd16943     1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHV-DQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvgEGTGLGLSLSYRI 79

                          90       100
                  ....*....|....*....|....*.
gi 1101469627 703 IEEHQGRIHVESEEGKGTVFHLTLPI 728
Cdd:cd16943    80 IQKHGGTIRVASVPGGGTRFTIILPI 105

COG4251

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...

321-731

3.99e-32

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];

Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 131.06 E-value: 3.99e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 321 TFIVDPQKKYKQIKKKYEKYGEIREEMLFQMANGQYKELEFTSKRTILEGQHLTILRNVSDRKRMEKELRESELKFRKVF 400
Cdd:COG4251    89 LALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALIL 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 401 NGSMDGKVLFDNQFRIIDANPLASRILGMPDEELRAYTVPDILSLFDIENAGVPARKIDLEgmDNEIPFLLSSSDSRKLE 480
Cdd:COG4251   169 ALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLL--LLLLLLVLLLLLILLLL 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 481 FSFKRNIIQNMNLAIFKDVTEAKELEERLRKSDTlhvvgEL---AAGIAHEIRNPMTALKGFIQLLQ----GSIEGEYSL 553
Cdd:COG4251   247 LLILVLELLELRLELEELEEELEERTAELERSNE-----ELeqfAYVASHDLREPLRKISGFSQLLEedygDKLDEEGRE 321

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 554 YFNVITSELKRIESIITEFLILAK--PQAILYEEKDVTQIMKDTADLLNAQANLVNVQIHLnltGNIPPIYCEPNQLKQV 631
Cdd:COG4251   322 YLERIRDAAERMQALIDDLLAYSRvgRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEV---GPLPTVRGDPTLLRQV 398

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 632 FINILKNAIEVMPGG--GNIYVTIQPSDqDHILISFQDEGTGISEDKLKRLGEPFYTTKDR----GTGLGLMVSYKIIEE 705
Cdd:COG4251   399 FQNLISNAIKYSRPGepPRIEIGAEREG-GEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRdeyeGTGIGLAIVKKIVER 477

                         410       420
                  ....*....|....*....|....*.
gi 1101469627 706 HQGRIHVESEEGKGTVFHLTLPIRQN 731
Cdd:COG4251   478 HGGRIWVESEPGEGATFYFTLPKAPA 503

KinE

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...

26-273

8.17e-32

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 130.09 E-value: 8.17e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  26 RLKSDLNRYHVIMNNTLDAIFICRKEMKIVQANEAAARMMQIEAESLINRSVLDFLYSVPQEELnKAVKKFLKKGHLWKE 105
Cdd:COG5809     9 QLRKSEQRFRSLFENAPDAILILDLEGKILKVNPAAERIFGYTEDELLGTNILDFLHPDDEKEL-REILKLLKEGESRDE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 106 VPIKLDSGATKYIEFLAR-----DGIGE-DYFFVVMRDISSKKILEREFSMNEQLFKDLFDRAVDGIVLFDKDGGFIDAN 179
Cdd:COG5809    88 LEFELRHKNGKRLEFSSKlspifDQNGDiEGMLAISRDITERKRMEEALRESEEKFRLIFNHSPDGIIVTDLDGRIIYAN 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 180 LSFCKSFEIGQNELSHLSLRHFTDGENKKHLKE-IWETLRRKGNAKGELPVKLRSGEEKLFEF---TITSNLISGFYMSI 255
Cdd:COG5809   168 PAACKLLGISIEELIGKSILELIHSDDQENVAAfISQLLKDGGIAQGEVRFWTKDGRWRLLEAsgaPIKKNGEVDGIVII 247

                         250
                  ....*....|....*...
gi 1101469627 256 MRDITEKRLMELKLFKSE 273
Cdd:COG5809   248 FRDITERKKLEELLRKSE 265

HATPase_c

smart00387

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

625-729

8.80e-32

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 119.29 E-value: 8.80e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  625 PNQLKQVFINILKNAIEVMPGGGNIYVTIQPsDQDHILISFQDEGTGISEDKLKRLGEPFYTTKDR-----GTGLGLMVS 699
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEGGRITVTLER-DGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkigGTGLGLSIV 81

                           90       100       110
                   ....*....|....*....|....*....|
gi 1101469627  700 YKIIEEHQGRIHVESEEGKGTVFHLTLPIR 729
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGTTFTITLPLE 111

HATPase_c

pfam02518

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...

625-730

2.15e-30

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 115.54 E-value: 2.15e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 625 PNQLKQVFINILKNAIEVMPGGGNIYVTIqpSDQDHILISFQDEGTGISEDKLKRLGEPFYTTKDR---GTGLGLMVSYK 701
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAAKAGEITVTL--SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRgggGTGLGLSIVRK 80

                          90       100
                  ....*....|....*....|....*....
gi 1101469627 702 IIEEHQGRIHVESEEGKGTVFHLTLPIRQ 730
Cdd:pfam02518  81 LVELLGGTITVESEPGGGTTVTLTLPLAQ 109

PAS

PAS domain [Signal transduction mechanisms];

145-389

1.09e-29

PAS domain [Signal transduction mechanisms];

Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 118.59 E-value: 1.09e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 145 EREFSMNEQLFKDLFDRAVDGIVLFDKDGGFIDANLSFCKSFEIGQNELSHLSLRHFTDGEN-KKHLKEIWETLRRKGNA 223
Cdd:COG2202     3 EEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDdDEFLELLRAALAGGGVW 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 224 KGELPVKLRSGEEKLFEFTIT-----SNLISGfYMSIMRDITEKRLMELKLFKSEERFREIFENAMDAIVIWSDDGKIAK 298
Cdd:COG2202    83 RGELRNRRKDGSLFWVELSISpvrdeDGEITG-FVGIARDITERKRAEEALRESEERLRLLVENAPDGIFVLDLDGRILY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 299 ANESACRIFELPMDKLLETNLCTFIVDPQKKYKQIKKKYEKYGEIRE---EMLFQMANGQYKELEFTSKRTILEGQ---H 372
Cdd:COG2202   162 VNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLEGGRESyelELRLKDGDGRWVWVEASAVPLRDGGEvigV 241

                         250
                  ....*....|....*..
gi 1101469627 373 LTILRNVSDRKRMEKEL 389
Cdd:COG2202   242 LGIVRDITERKRAEEAL 258

PRK09303

histidine kinase;

501-728

2.07e-27

histidine kinase;

Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 114.66 E-value: 2.07e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 501 EAKELEERLRKSDtlhvvgELAAGIAHEIRNPMTALKGFIQLLQ-GSIEGEYSL-------YFNVITSELKRIESIITEF 572
Cdd:PRK09303  140 ENETLLEQLKFKD------RVLAMLAHDLRTPLTAASLALETLElGQIDEDTELkpalieqLQDQARRQLEEIERLITDL 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 573 LILAKPQA----ILYEEKDVTQIMKDTADLLNAQANLVNVQIHLNLTGNIPPIYCEPNQLKQVFINILKNAIEVMPGGGN 648
Cdd:PRK09303  214 LEVGRTRWealrFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGT 293

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 649 IYVTIQPSDQDHILISFQDEGTGISEDKLKRLGEP-FYTTKDRGT---GLGLMVSYKIIEEHQGRIHVESEEGKGTVFHL 724
Cdd:PRK09303  294 ITLSMLHRTTQKVQVSICDTGPGIPEEEQERIFEDrVRLPRDEGTegyGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHF 373


                  ....
gi 1101469627 725 TLPI 728
Cdd:PRK09303  374 TLPV 377

HATPase_TmoS-FixL-DctS-like

cd16920

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

628-727

6.17e-27

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 105.17 E-value: 6.17e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 628 LKQVFINILKNAIEVMPGGG----NIYVTIQPSDQDHILISFQDEGTGISEDKLKRLGEPFYTTKDRGTGLGLMVSYKII 703
Cdd:cd16920     1 IQQVLINLVRNGIEAMSEGGcerrELTIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSII 80

                          90       100
                  ....*....|....*....|....
gi 1101469627 704 EEHQGRIHVESEEGKGTVFHLTLP 727
Cdd:cd16920    81 EAHGGRLSVESPAGGGATFQFTLP 104

PAS

PAS domain [Signal transduction mechanisms];

266-509

7.33e-27

PAS domain [Signal transduction mechanisms];

Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 110.11 E-value: 7.33e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 266 ELKLFKSEERFREIFENAMDAIVIWSDDGKIAKANESACRIFELPMDKLLETNLCTFIV--DPQKKYKQIKKKYEKYGEI 343
Cdd:COG2202     3 EEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPpeDDDEFLELLRAALAGGGVW 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 344 REEMLFQMANGQYKELEFTSKRTILEGQHLT----ILRNVSDRKRMEKELRESELKFRKVFNGSMDGKVLFDNQFRIIDA 419
Cdd:COG2202    83 RGELRNRRKDGSLFWVELSISPVRDEDGEITgfvgIARDITERKRAEEALRESEERLRLLVENAPDGIFVLDLDGRILYV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 420 NPLASRILGMPDEELRAYTVPDILSLFDIENAGVPARK-IDLEGMDNEIPFLLSSSDSRKLEFSFKRNIIQNMN-----L 493
Cdd:COG2202   163 NPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRlLEGGRESYELELRLKDGDGRWVWVEASAVPLRDGGevigvL 242

                         250
                  ....*....|....*.
gi 1101469627 494 AIFKDVTEAKELEERL 509
Cdd:COG2202   243 GIVRDITERKRAEEAL 258

CitA

COG3290

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...

373-729

9.27e-27

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];

Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 113.02 E-value: 9.27e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 373 LTILRNVSDRKRMEKELRESELKFRKVFNGSMDGKVLFDNQFRIIDANPLASRILGMPDEELRAYTVPDILslfdienag 452
Cdd:COG3290    63 LLLLLLAALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGLDAIGRPIDEVLAEV--------- 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 453 VPARKIDLEGMDNEIPFLLSSSDSRklefsfkRNIIQNMNLAIFKDVTEAKELEERLRKSDTLhvVGELAAgIAHEIRNP 532
Cdd:COG3290   134 LETGERDEEILLNGRVLVVNRVPIR-------DDGRVVGAVATFRDRTELERLEEELEGVKEL--AEALRA-QRHDFRNH 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 533 MTALKGFIQLLQGSIEGEYslyfnvITSELKRIESIITEFLILAKPQAIlyeekdvtqimkdtADLLNAQANLV---NVQ 609
Cdd:COG3290   204 LHTISGLLQLGEYDEALEY------IDEISEELQELIDSLLSRIGNPVL--------------AALLLGKAARArerGID 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 610 IHLNLTGNIPPIYCEPNQLKQVFINILKNAIEVMPGGGN----IYVTIQpSDQDHILISFQDEGTGISEDKLKRLGEPFY 685
Cdd:COG3290   264 LTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAVEKLPEeerrVELSIR-DDGDELVIEVEDSGPGIPEELLEKIFERGF 342

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1101469627 686 TTKDR-GTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPIR 729
Cdd:COG3290   343 STKLGeGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKE 387

PAS

PAS domain [Signal transduction mechanisms];

22-269

1.90e-25

PAS domain [Signal transduction mechanisms];

Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 106.26 E-value: 1.90e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  22 EENDRLKSDLNRYHVIMNNTLDAIFICRKEMKIVQANEAAARMMQIEAESLINRSVLDFLYSVPQEELNKAVKKFLKKGH 101
Cdd:COG2202     1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAALAGGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 102 LWK-EVPIKLDSGATKYIEFLA---RDGIGE-DYFFVVMRDISSKKILEREFSMNEQLFKDLFDRAVDGIVLFDKDGGFI 176
Cdd:COG2202    81 VWRgELRNRRKDGSLFWVELSIspvRDEDGEiTGFVGIARDITERKRAEEALRESEERLRLLVENAPDGIFVLDLDGRIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 177 DANLSFCKSFEIGQNELSHLSLRHFTDGENKKHLKEIWETLRRKGNAKGELPVKLRSGEEKLFEFTITSNLISG-----F 251
Cdd:COG2202   161 YVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLEGGRESYELELRLKDGDGRWVWVEASAVPLRDggeviG 240

                         250
                  ....*....|....*...
gi 1101469627 252 YMSIMRDITEKRLMELKL 269
Cdd:COG2202   241 VLGIVRDITERKRAEEAL 258

glnL

PRK11073

nitrogen regulation protein NR(II);

398-729

5.21e-25

nitrogen regulation protein NR(II);

Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 107.09 E-value: 5.21e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 398 KVFNGSMDGKVLFDNQFRIIDANPLASRILGMPDEELRAYTVPDILSLFdienagvparKIDLEGM-----------DNE 466
Cdd:PRK11073   11 QILNSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYF----------SLNIELMreslqagqgftDNE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 467 IPFLLSSSdSRKLEFSFKRnIIQNMNLAIFKDVTEAKELEERLRKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLQGS 546
Cdd:PRK11073   81 VTLVIDGR-SHILSLTAQR-LPEGMILLEMAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 547 I-EGEYSLYFNVITSELKRIESIITEFLilaKPQailyeeKDVTQIMKDTADLLNAQANLV------NVQIHLNLTGNIP 619
Cdd:PRK11073  159 LpDPALTEYTKVIIEQADRLRNLVDRLL---GPQ------RPGTHVTESIHKVAERVVQLVslelpdNVRLIRDYDPSLP 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 620 PIYCEPNQLKQVFINILKNAIEVM-PGGGNI--------YVTIQpsDQDHIL---ISFQDEGTGISEDKLKRLGEPFYTT 687
Cdd:PRK11073  230 ELAHDPDQIEQVLLNIVRNALQALgPEGGTItlrtrtafQLTLH--GERYRLaarIDIEDNGPGIPPHLQDTLFYPMVSG 307

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1101469627 688 KDRGTGLGLMVSYKIIEEHQGRIHVESEEGKgTVFHLTLPIR 729
Cdd:PRK11073  308 REGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPIR 348

phoR

PRK11006

phosphate regulon sensor histidine kinase PhoR;

367-729

6.97e-25

phosphate regulon sensor histidine kinase PhoR;

Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 108.17 E-value: 6.97e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 367 ILEGQHLTILRNvsdRKRmEKELRESELKFRkvfNG--SM-DGKVLFDNQFRIIDANPLASRILGM--PDEELRaytvpD 441
Cdd:PRK11006   75 LFYGLYQMQLRN---RKR-RRELGNLIKRFR---SGaeSLpDAVVLTTEEGNIFWCNGLAQQLLGFrwPEDNGQ-----N 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 442 ILSLFdienagvpaRKID----LEGMDNEIPFLLSSSDSRKLEFSFKRnIIQNMNLAIFKDVTEAKELEERLRksdtlhv 517
Cdd:PRK11006  143 ILNLL---------RYPEftqyLKTRDFSRPLTLVLNNGRHLEIRVMP-YTEGQLLMVARDVTQMHQLEGARR------- 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 518 vgELAAGIAHEIRNPMTALKGFIQLLQ-----GSIEGEYslyFNVITSELKRIESIITEFLILAK----PQAILYEEKDV 588
Cdd:PRK11006  206 --NFFANVSHELRTPLTVLQGYLEMMQdqpleGALREKA---LHTMREQTQRMEGLVKQLLTLSKieaaPTIDLNEKVDV 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 589 TQIM----KDTADLLNAQANLV-NVQIHLNLTGNippiycePNQLKQVFINILKNAIEVMPGGGNIYVTIQPSDQDhILI 663
Cdd:PRK11006  281 PMMLrvleREAQTLSQGKHTITfEVDNSLKVFGN-------EDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQG-AEF 352

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1101469627 664 SFQDEGTGISEDKLKRLGEPFY-TTKDR-----GTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPIR 729
Cdd:PRK11006  353 SVEDNGPGIAPEHIPRLTERFYrVDKARsrqtgGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPER 424

HATPase_EvgS-ArcB-TorS-like

cd16922

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...

628-727

6.34e-24

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 96.79 E-value: 6.34e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 628 LKQVFINILKNAIEVMPGGG-NIYVTIQPSDQDHILISFQ--DEGTGISEDKLKRLGEPF------YTTKDRGTGLGLMV 698
Cdd:cd16922     1 LRQILLNLLGNAIKFTEEGEvTLRVSLEEEEEDGVQLRFSveDTGIGIPEEQQARLFEPFsqadssTTRKYGGTGLGLAI 80

                          90       100
                  ....*....|....*....|....*....
gi 1101469627 699 SYKIIEEHQGRIHVESEEGKGTVFHLTLP 727
Cdd:cd16922    81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109

PRK11100

sensory histidine kinase CreC; Provisional

526-729

1.02e-23

sensory histidine kinase CreC; Provisional

Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 105.31 E-value: 1.02e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 526 AHEIRNPMTALKGFIQLLQGSIEGEYSLYF--NvITSELKRIESIITEFLILAK---PQAILYEEK-DVTQIMKDTADLL 599
Cdd:PRK11100  264 THELKSPLAAIRGAAELLQEDPPPEDRARFtgN-ILTQSARLQQLIDRLLELARleqRQELEVLEPvALAALLEELVEAR 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 600 NAQANLVNVQIHLNLTGNIppIYCEPNQLKQVFINILKNAIEVMPGGGNIYVTIQPsDQDHILISFQDEGTGISEDKLKR 679
Cdd:PRK11100  343 EAQAAAKGITLRLRPDDAR--VLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEV-DGEQVALSVEDQGPGIPDYALPR 419

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1101469627 680 LGEPFYT-----TKDRGTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPIR 729
Cdd:PRK11100  420 IFERFYSlprpaNGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRH 474

HATPase_HupT_MifS-like

cd16976

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

628-726

4.99e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.

Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 91.36 E-value: 4.99e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 628 LKQVFINILKNAIEVMPGGGNIYVTIQPSDQ-DHILISFQDEGTGISEDKLKRLGEPFYTTKD--RGTGLGLMVSYKIIE 704
Cdd:cd16976     1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLgGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPvgKGTGLGLSISYGIVE 80

                          90       100
                  ....*....|....*....|..
gi 1101469627 705 EHQGRIHVESEEGKGTVFHLTL 726
Cdd:cd16976    81 EHGGRLSVANEEGAGARFTFDL 102

PRK13557

histidine kinase; Provisional

498-737

3.92e-21

histidine kinase; Provisional

Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 97.82 E-value: 3.92e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 498 DVTEAKELEERLRKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLQGSIEGEYSLYFNV------ITSELKRIESIITE 571
Cdd:PRK13557  143 DVSRRRDAEDALRQAQKMEALGQLTGGIAHDFNNLLQVMSGYLDVIQAALSHPDADRGRMarsvenIRAAAERAATLTQQ 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 572 FLILAKPQAI---LYEEKDVTQIMKDTADLLNAQAnlvnVQIHLNLTGNIPPIYCEPNQLKQVFINILKNAIEVMPGGGN 648
Cdd:PRK13557  223 LLAFARKQRLegrVLNLNGLVSGMGELAERTLGDA----VTIETDLAPDLWNCRIDPTQAEVALLNVLINARDAMPEGGR 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 649 IYV---TIQPSDQD-----------HILISFQDEGTGISEDKLKRLGEPFYTTKD--RGTGLGLMVSYKIIEEHQGRIHV 712
Cdd:PRK13557  299 VTIrtrNVEIEDEDlamyhglppgrYVSIAVTDTGSGMPPEILARVMDPFFTTKEegKGTGLGLSMVYGFAKQSGGAVRI 378

                         250       260
                  ....*....|....*....|....*
gi 1101469627 713 ESEEGKGTVFHLTLPIRQNTEERRS 737
Cdd:PRK13557  379 YSEVGEGTTVRLYFPASDQAENPEQ 403

HATPase_CckA-like

cd16919

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...

628-727

1.06e-20

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).

Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 87.82 E-value: 1.06e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 628 LKQVFINILKNAIEVMPGGGNIYVTI--QPSDQD------------HILISFQDEGTGISEDKLKRLGEPFYTTKD--RG 691
Cdd:cd16919     1 LELAILNLAVNARDAMPEGGRLTIETsnQRVDADyalnyrdlipgnYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEvgKG 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1101469627 692 TGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLP 727
Cdd:cd16919    81 TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116

HATPase_Glnl-NtrB-like

cd16918

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

628-727

2.45e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).

Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 86.69 E-value: 2.45e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 628 LKQVFINILKNAIEVMPG-GGNI--------YVTI-QPSDQDHILISFQDEGTGISEDKLKRLGEPFYTTKDRGTGLGLM 697
Cdd:cd16918     1 LIQVFLNLVRNAAQALAGsGGEIilrtrtqrQVTLgHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLA 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1101469627 698 VSYKIIEEHQGRIHVESEEGKgTVFHLTLP 727
Cdd:cd16918    81 IAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109

COG4192

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...

483-727

3.56e-20

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];

Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 95.14 E-value: 3.56e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 483 FKRNIIQnmnlaifKDVTEAKELEERLRKSDTL-------------HVVGELAAGIAHEIRNPMTALKGFIQLLQGSIEG 549
Cdd:COG4192   392 FRDQAIE-------KTQELETEIEERKRIEKNLrqtqdeliqaakmAVVGQTMTSLAHELNQPLNAMSMYLFSAKKALEQ 464

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 550 E----YSLYFNVITSELKRIESIITEFLILAKPQAILYEEKDVTQIMKDTADLLNAQANLVNVQIHLNltgNIPPIYCEP 625
Cdd:COG4192   465 EnyaqLPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQPVDLRQVIEQAWELVESRAKPQQITLHIP---DDLMVQGDQ 541

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 626 NQLKQVFINILKNAIEVMPGGGNIYVTIQpSDQDHILISFQDEGTGIseDKLKRLGEPFYTTKDRGTGLGLMVSYKIIEE 705
Cdd:COG4192   542 VLLEQVLVNLLVNALDAVATQPQISVDLL-SNAENLRVAISDNGNGW--PLVDKLFTPFTTTKEVGLGLGLSICRSIMQQ 618

                         250       260
                  ....*....|....*....|..
gi 1101469627 706 HQGRIHVESEEGKGTVFHLTLP 727
Cdd:COG4192   619 FGGDLYLASTLERGAMVILEFN 640

HATPase_NtrY-like

cd16944

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

627-727

2.02e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.

Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 84.13 E-value: 2.02e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 627 QLKQVFINILKNAIEVMPG--GGNIYVTIQPSD--QDHILISFQDEGTGISEDKLKRLGEPFYTTKDRGTGLGLMVSYKI 702
Cdd:cd16944     4 QISQVLTNILKNAAEAIEGrpSDVGEVRIRVEAdqDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIVKKI 83

                          90       100
                  ....*....|....*....|....*
gi 1101469627 703 IEEHQGRIHVESEEGKGTVFHLTLP 727
Cdd:cd16944    84 MEEHGGRISLSNREAGGACIRIILP 108

HATPase_BaeS-like

cd16946

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

624-727

3.85e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.

Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 83.28 E-value: 3.85e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 624 EPNQLKQVFINILKNAIEVMPGGGNIYVTIQPSDQDhILISFQDEGTGISEDKLKRLGEPFYTTKDR------GTGLGLM 697
Cdd:cd16946     1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQE-VRLDVEDSAPGVSDDQLARLFERFYRVESSrnrasgGSGLGLA 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 1101469627 698 VSYKIIEEHQGRIHVESEEGKGTVFHLTLP 727
Cdd:cd16946    80 ICHNIALAHGGTISAEHSPLGGLRLVLTLP 109

PRK09959

acid-sensing system histidine kinase EvgS;

496-728

5.89e-18

acid-sensing system histidine kinase EvgS;

Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 89.02 E-value: 5.89e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  496 FKDVTEAKEL-----EERLRKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLQGS-IEGEYSL-YFNVITSELKRIESI 568
Cdd:PRK09959   685 WQDITETRDLihaleVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGSgLSKEQRVeAISLAYATGQSLLGL 764

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  569 ITEFLILAKPQAILYEEK----DVTQIMKDTADLLNAQAnlVNVQIHLNLTGNIPPIY---CEPNQLKQVFINILKNAIE 641
Cdd:PRK09959   765 IGEILDVDKIESGNYQLQpqwvDIPTLVQNTCHSFGAIA--ASKSIALSCSSTFPDHYlvkIDPQAFKQVLSNLLSNALK 842

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  642 VMPGGG-NIYVTIQPSDQDHILI--SFQDEGTGISEDKLKRLGEPFYTT----KDRGTGLGLMVSYKIIEEHQGRIHVES 714
Cdd:PRK09959   843 FTTEGAvKITTSLGHIDDNHAVIkmTIMDSGSGLSQEEQQQLFKRYSQTsagrQQTGSGLGLMICKELIKNMQGDLSLES 922

                          250
                   ....*....|....
gi 1101469627  715 EEGKGTVFHLTLPI 728
Cdd:PRK09959   923 HPGIGTTFTITIPV 936

PRK15347

two component system sensor kinase;

500-728

6.96e-17

two component system sensor kinase;

Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 85.08 E-value: 6.96e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 500 TEAKELEERL--RKSDTLHVvgelaagIAHEIRNPMTALKGFIQLLQGS---------IEGEY--SLYFNVITSEL---K 563
Cdd:PRK15347  385 AEAKQRAEQAnkRKSEHLTT-------ISHEIRTPLNGVLGALELLQNTpltaeqmdlADTARqcTLSLLAIINNLldfS 457

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 564 RIESiiteflilakPQAIL-YEEKDVTQIMKDTadLLNAQANLVNVQIHLN--LTGNIP-PIYCEPNQLKQVFINILKNA 639
Cdd:PRK15347  458 RIES----------GQMTLsLEETALLPLLDQA--MLTIQGPAQSKSLTLRtfVGAHVPlYLHLDSLRLRQILVNLLGNA 525

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 640 IEVMPGGGnIYVTIQpSDQDHILISFQDEGTGISEDKLKRLGEPFYTTKD--RGTGLGLMVSYKIIEEHQGRIHVESEEG 717
Cdd:PRK15347  526 VKFTETGG-IRLRVK-RHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADThsQGTGLGLTIASSLAKMMGGELTLFSTPG 603

                         250
                  ....*....|.
gi 1101469627 718 KGTVFHLTLPI 728
Cdd:PRK15347  604 VGSCFSLVLPL 614

PRK09835

Cu(+)/Ag(+) sensor histidine kinase;

522-727

1.52e-16

Cu(+)/Ag(+) sensor histidine kinase;

Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 82.90 E-value: 1.52e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 522 AAGIAHEIRNPMTAL--KGFIQLLQGSIEGEYS--LYFNVitSELKRIESIITEFLILAKP--QAILYEEK--DVTQIMK 593
Cdd:PRK09835  266 SADIAHEIRTPITNLitQTEIALSQSRSQKELEdvLYSNL--EELTRMAKMVSDMLFLAQAdnNQLIPEKKmlDLADEVG 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 594 DTADLLNAQANLVNVQIHLNltGNIPPIYCEPNQLKQVFINILKNAIEVMPGGGNIYVTIQPSDqDHILISFQDEGTGIS 673
Cdd:PRK09835  344 KVFDFFEAWAEERGVELRFV--GDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVD-HQVQLVVENPGTPIA 420

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 674 EDKLKRLGEPFYTT------KDRGTGLGLMVSYKIIEEHQGRIHVESeEGKGTVFHLTLP 727
Cdd:PRK09835  421 PEHLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVISLP 479

PRK10549

two-component system sensor histidine kinase BaeS;

523-728

5.04e-16

two-component system sensor histidine kinase BaeS;

Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 81.22 E-value: 5.04e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 523 AGIAHEIRNPMTALKGFIQLLQGSI-----EGEYSLYFNVitselkrieSIITEF------LILAKPQAILYEEK--DVT 589
Cdd:PRK10549  245 ADISHELRTPLAVLRGELEAIQDGVrkftpESVASLQAEV---------GTLTKLvddlhqLSLSDEGALAYRKTpvDLV 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 590 QIMKDTADLLNAQANLVNVQIHLNLTGNIPpIYCEPNQLKQVFINILKNAIEVMPGGGNIYVTIQpSDQDHILISFQDEG 669
Cdd:PRK10549  316 PLLEVAGGAFRERFASRGLTLQLSLPDSAT-VFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAE-QRDKTLRLTFADSA 393

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1101469627 670 TGISEDKLKRLGEPFYTT---KDR---GTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPI 728
Cdd:PRK10549  394 PGVSDEQLQKLFERFYRTegsRNRasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPL 458

HATPase_CpxA-like

cd16949

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

628-727

8.44e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.

Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 73.51 E-value: 8.44e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 628 LKQVFINILKNAIEVMPGggNIYVTIQpSDQDHILISFQDEGTGISEDKLKRLGEPFY---TTKDR---GTGLGLMVSYK 701
Cdd:cd16949     1 LARALENVLRNALRYSPS--KILLDIS-QDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdSARDResgGTGLGLAIAER 77

                          90       100
                  ....*....|....*....|....*.
gi 1101469627 702 IIEEHQGRIHVESEEGKGTVFHLTLP 727
Cdd:cd16949    78 AIEQHGGKIKASNRKPGGLRVRIWLP 103

cpxA

PRK09470

envelope stress sensor histidine kinase CpxA;

525-728

1.30e-15

envelope stress sensor histidine kinase CpxA;

Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 79.98 E-value: 1.30e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 525 IAHEIRNPMTALkgfiQLLQGSI---EGEYSlYFNVITSELKRIESIITEFLILAKPQAILYEEKDVTQIMKDTADLLNa 601
Cdd:PRK09470  250 ISHELRTPLTRL----QLATALLrrrQGESK-ELERIETEAQRLDSMINDLLVLSRNQQKNHLERETFKANSLWSEVLE- 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 602 QANLVNVQIHLNLTGNIPP----IYCEPNQLKQVFINILKNAIEVmpGGGNIYVTIQpSDQDHILISFQDEGTGISEDKL 677
Cdd:PRK09470  324 DAKFEAEQMGKSLTVSAPPgpwpINGNPNALASALENIVRNALRY--SHTKIEVAFS-VDKDGLTITVDDDGPGVPEEER 400

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1101469627 678 KRLGEPFY---TTKDR---GTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPI 728
Cdd:PRK09470  401 EQIFRPFYrvdEARDResgGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPL 457

HATPase_BasS-like

cd16940

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

628-721

1.13e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.

Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 70.51 E-value: 1.13e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 628 LKQVFINILKNAIEVMPGGGNIYVTIQPSDQDHILISfqDEGTGISEDKLKRLGEPFY---TTKDRGTGLGLMVSYKIIE 704
Cdd:cd16940    14 LFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIRVE--DNGPGIDEEELEALFERFYrsdGQNYGGSGLGLSIVKRIVE 91

                          90
                  ....*....|....*..
gi 1101469627 705 EHQGRIHVESEEGKGTV 721
Cdd:cd16940    92 LHGGQIFLGNAQGGGLE 108

PRK10490

sensor protein KdpD; Provisional

507-727

1.89e-14

sensor protein KdpD; Provisional

Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 77.38 E-value: 1.89e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 507 ERLRKSdtlhvvgeLAAGIAHEIRNPMTALKGFIQLLQGSIEGEYSLY---FNVI------TSEL-------KRIES--- 567
Cdd:PRK10490  661 EQLRNA--------LLAALSHDLRTPLTVLFGQAEILTLDLASEGSPHarqASEIrqqvlnTTRLvnnlldmARIQSggf 732

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 568 -IITEFLILakpqailyeEKDVTQIMKDTADLLNAQanlvnvQIHLNLTGNIPPIYCEPNQLKQVFINILKNAIEVmpGG 646
Cdd:PRK10490  733 nLRKEWLTL---------EEVVGSALQMLEPGLSGH------PINLSLPEPLTLIHVDGPLFERVLINLLENAVKY--AG 795

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 647 GNIYVTIQPS-DQDHILISFQDEGTGISEDKLKRLGEPFYTTKDR----GTGLGLMVSYKIIEEHQGRIHVESEEGKGTV 721
Cdd:PRK10490  796 AQAEIGIDAHvEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKEsaipGVGLGLAICRAIVEVHGGTIWAENRPEGGAC 875


                  ....*.
gi 1101469627 722 FHLTLP 727
Cdd:PRK10490  876 FRVTLP 881

HATPase_FilI-like

cd16921

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

628-727

2.28e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 69.66 E-value: 2.28e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 628 LKQVFINILKNAIEVMPGGGNIYVTIQPSDQ-DHILISFQDEGTGISEDKLKRLGEPFYTTKDR----GTGLGLMVSYKI 702
Cdd:cd16921     1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVgEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSReeyeGTGVGLAIVRKI 80

                          90       100
                  ....*....|....*....|....*
gi 1101469627 703 IEEHQGRIHVESEEGKGTVFHLTLP 727
Cdd:cd16921    81 IERHGGRIWLESEPGEGTTFYFTLP 105

HATPase_CreC-like

cd16945

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

624-726

3.86e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.

Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 69.03 E-value: 3.86e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 624 EPNQLKQVFINILKNAIEVMPGGGNIYVTIQpSDQDHILISFQDEGTGISEDKLKRLGEPFYT-----TKDRGTGLGLMV 698
Cdd:cd16945     1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLE-ADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAF 79

                          90       100
                  ....*....|....*....|....*...
gi 1101469627 699 SYKIIEEHQGRIHVESEEGKGTVFhLTL 726
Cdd:cd16945    80 VQEVAQLHGGRITLRNRPDGVLAF-LTL 106

PRK11466

hybrid sensory histidine kinase TorS; Provisional

523-732

6.77e-14

hybrid sensory histidine kinase TorS; Provisional

Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 75.71 E-value: 6.77e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 523 AGIAHEIRNPMTALKGFIQLLQGS-IEGEYSLYFNVITSELKRIESIITEFLILAKPQA-----ILYEEK-DVTQIMKDT 595
Cdd:PRK11466  449 AAMSHEIRTPLYGILGTAQLLADNpALNAQRDDLRAITDSGESLLTILNDILDYSAIEAggknvSVSDEPfEPRPLLEST 528

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 596 ADLLNAQANLVNVQIHLNLTGNIPP-IYCEPNQLKQVFINILKNAIEVMPGGGNIYVTIqpSDQDHILISFQDEGTGISE 674
Cdd:PRK11466  529 LQLMSGRVKGRPIRLATDIADDLPTaLMGDPRRIRQVITNLLSNALRFTDEGSIVLRSR--TDGEQWLVEVEDSGCGIDP 606

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 675 DKLKRLGEPFYTTKDR--GTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPIRQNT 732
Cdd:PRK11466  607 AKLAEIFQPFVQVSGKrgGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRVAT 666

NtrB

COG3852

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

26-154

8.99e-14

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 73.34 E-value: 8.99e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  26 RLKSDLNRYHVIMNNTLDAIFICRKEMKIVQANEAAARMMQIEAESLINRSVLDFLysVPQEELNKAVKKFLKKGHLWK- 104
Cdd:COG3852     1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELF--PEDSPLRELLERALAEGQPVTe 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1101469627 105 -EVPIKLDSGATKYIEFLA---RDGIGEDYFFVVMRDISSKKILEREFSMNEQL 154
Cdd:COG3852    79 rEVTLRRKDGEERPVDVSVsplRDAEGEGGVLLVLRDITERKRLERELRRAEKL 132

HATPase_TutC-TodS-like

cd16925

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...

624-727

2.13e-13

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.

Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 67.13 E-value: 2.13e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 624 EPNQLKQVFINILKNAIEVMPGGGNIYVTIQPSDQDHILISFQDEGTGISEDKLKRLGEPFY------TTKDRGTGLGLM 697
Cdd:cd16925     1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRqgdgssTRAHGGTGLGLS 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1101469627 698 VSYKIIEEHQGRIHVESEEGKGTVFHLTLP 727
Cdd:cd16925    81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110

PRK11091

aerobic respiration control sensor protein ArcB; Provisional

497-727

2.67e-13

aerobic respiration control sensor protein ArcB; Provisional

Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 73.44 E-value: 2.67e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 497 KDVTEAKELEERLRKSDTLHvvGELAAGIAHEIRNPMTALKGFIQ-LLQGSIEGEYSLYFNVITS-------------EL 562
Cdd:PRK11091  264 RDITERKRYQDALEKASRDK--TTFISTISHELRTPLNGIVGLSRiLLDTELTAEQRKYLKTIHVsaitlgnifndiiDM 341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 563 KRIESiitEFLILAkPQAIlyeekDVTQIMKDTADLLNAQANLVNVQIHLNLTGNIPP-IYCEPNQLKQVFINILKNAIE 641
Cdd:PRK11091  342 DKMER---RKLQLD-NQPI-----DFTDFLADLENLSGLQAEQKGLRFDLEPLLPLPHkVITDGTRLRQILWNLISNAVK 412

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 642 VMPGGGnIYVTIQPSDQDHILISFQDEGTGISEDKLKRLGEPFYTTKDR-------GTGLGLMVSYKIIEEHQGRIHVES 714
Cdd:PRK11091  413 FTQQGG-VTVRVRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDShggkpatGTGIGLAVSKRLAQAMGGDITVTS 491

                         250
                  ....*....|...
gi 1101469627 715 EEGKGTVFHLTLP 727
Cdd:PRK11091  492 EEGKGSCFTLTIH 504

envZ

PRK09467

osmolarity sensor protein; Provisional

521-717

4.69e-13

osmolarity sensor protein; Provisional

Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 71.87 E-value: 4.69e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 521 LAAGIAHEIRNPMTAlkgfIQLLQGSIEGEYSLYFNVITSELKRIESIITEFLILAKP-QAILYEEKDVTQIMKDTAdll 599
Cdd:PRK09467  232 LMAGVSHDLRTPLTR----IRLATEMMSEEDGYLAESINKDIEECNAIIEQFIDYLRTgQEMPMEMADLNALLGEVI--- 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 600 NAQANLvNVQIHLNLTGNIPPIYCEPNQLKQVFINILKNAIEVmpGGGNIYVTiqpSDQDHILISFQ--DEGTGISEDKL 677
Cdd:PRK09467  305 AAESGY-EREIETALQPGPIEVPMNPIAIKRALANLVVNAARY--GNGWIKVS---SGTEGKRAWFQveDDGPGIPPEQL 378

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1101469627 678 KRLGEPFyTTKDR-----GTGLGLMVSYKIIEEHQGRIHV-ESEEG 717
Cdd:PRK09467  379 KHLFQPF-TRGDSargssGTGLGLAIVKRIVDQHNGKVELgNSEEG 423

HATPase_BceS-YxdK-YvcQ-like

cd16948

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

628-727

7.32e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.

Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 65.38 E-value: 7.32e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 628 LKQVFINILKNAIEVMPGGGNIYVTIQpSDQDHILISFQDEGTGISEDKLKRLGEPFYTTKD-----RGTGLGLMVSYKI 702
Cdd:cd16948     6 LSFIIGQIVSNALKYSKQGGKIEIYSE-TNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENgrnfqESTGMGLYLVKKL 84

                          90       100
                  ....*....|....*....|....*
gi 1101469627 703 IEEHQGRIHVESEEGKGTVFHLTLP 727
Cdd:cd16948    85 CDKLGHKIDVESEVGEGTTFTITFP 109

HATPase_EcPhoR-like

cd16952

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

628-730

1.17e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.

Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 64.92 E-value: 1.17e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 628 LKQVFINILKNAIEVMPGGGNIYVTIQPSDQDHILiSFQDEGTGISEDKLKRLGEPFY------TTKDRGTGLGLMVSYK 701
Cdd:cd16952     1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARL-SVEDTGPGIPPEHIPRLTERFYrvdierCRNTGGTGLGLAIVKH 79

                          90       100
                  ....*....|....*....|....*....
gi 1101469627 702 IIEEHQGRIHVESEEGKGTVFHLTLPIRQ 730
Cdd:cd16952    80 VMSRHDARLLIASELGKGSRFTCLFPSSR 108

PRK10604

sensor protein RstB; Provisional

524-737

1.22e-12

sensor protein RstB; Provisional

Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 70.40 E-value: 1.22e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 524 GIAHEIRNPMTALKGFIQLLQGSIEGEYSlyfnVITSELKRIESIITEFLILA---KPQAILY-EEKDVTQIMKDTAD-- 597
Cdd:PRK10604  218 GIAHELRTPLVRLRYRLEMSDNLSAAESQ----ALNRDIGQLEALIEELLTYArldRPQNELHlSEPDLPAWLSTHLAdi 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 598 -LLNAQanlvnVQIHLNLTGNIPPIYCEPNQLKQVFINILKNAIEVmpGGGNIYVTIQpSDQDHILISFQDEGTGISEDK 676
Cdd:PRK10604  294 qAVTPE-----KTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRY--AHSRVRVSLL-LDGNQACLIVEDDGPGIPPEE 365

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1101469627 677 LKRLGEPFY---TTKDRGTG---LGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPIRQNTEERRS 737
Cdd:PRK10604  366 RERVFEPFVrldPSRDRATGgcgLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPVWHNLPQFTS 432

HATPase_YcbM-like

cd16947

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

617-726

2.73e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).

Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 64.46 E-value: 2.73e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 617 NIP--PIYCEPNQ--LKQVFINILKNAIEVMPGGGNIYVTIQpSDQDHILISFQDEGTGISEDKLKRLGEPFYTTKD--- 689
Cdd:cd16947     6 NIPdrPIYANANTeaLQRILKNLISNAIKYGSDGKFLGMTLR-EDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDsrn 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1101469627 690 ---RGTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTL 726
Cdd:cd16947    85 sakQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124

HATPase_BvrS-ChvG-like

cd16953

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

628-727

9.28e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.

Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 62.20 E-value: 9.28e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 628 LKQVFINILKNAIE-VMPGGGNIYVTIQPSdQDHILISFQDEGTGISEDKLKRLGEPFYTTKDRG------TGLGLMVSY 700
Cdd:cd16953     1 LGQVLRNLIGNAISfSPPDTGRITVSAMPT-GKMVTISVEDEGPGIPQEKLESIFDRFYTERPANeafgqhSGLGLSISR 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1101469627 701 KIIEEHQGRIHVESEE----GKGTVFHLTLP 727
Cdd:cd16953    80 QIIEAHGGISVAENHNqpgqVIGARFTVQLP 110

HisKA

pfam00512

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...

519-580

1.19e-11

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.

Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 60.30 E-value: 1.19e-11

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1101469627 519 GELAAGIAHEIRNPMTALKGFIQLLQ-GSIEGEYSLYFNVITSELKRIESIITEFLILAKPQA 580
Cdd:pfam00512   3 SEFLANLSHELRTPLTAIRGYLELLRdEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65

HisKA

smart00388

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...

519-580

4.71e-11

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.

Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 58.73 E-value: 4.71e-11

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1101469627  519 GELAAGIAHEIRNPMTALKGFIQLLQ-GSIEGEYSLYFNVITSELKRIESIITEFLILAKPQA 580
Cdd:smart00388   3 REFLANLSHELRTPLTAIRGYLELLLdTELSEEQREYLETILREAERLLRLINDLLDLSRIEA 65

PRK10841

two-component system sensor histidine kinase RcsC;

621-728

7.24e-11

two-component system sensor histidine kinase RcsC;

Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 65.77 E-value: 7.24e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 621 IYC--EPN----------QLKQVFINILKNAIEVMPGGGnIYVTIQpSDQDHILISFQDEGTGISEDKLKRLGEPFY--- 685
Cdd:PRK10841  544 LYCfiEPDvpvalngdpmRLQQVISNLLSNAIKFTDTGC-IVLHVR-VDGDYLSFRVRDTGVGIPAKEVVRLFDPFFqvg 621

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1101469627 686 TTKDR---GTGLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPI 728
Cdd:PRK10841  622 TGVQRnfqGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIPL 667

HisKA

cd00082

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...

519-577

1.00e-10

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.

Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 57.99 E-value: 1.00e-10

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1101469627 519 GELAAGIAHEIRNPMTALKGFIQLLQGSIEG--EYSLYFNVITSELKRIESIITEFLILAK 577
Cdd:cd00082     5 GEFLANVSHELRTPLTAIRGALELLEEELLDdeEQREYLERIREEAERLLRLINDLLDLSR 65

HATPase_SpaK_NisK-like

cd16975

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

626-713

1.51e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.

Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 58.63 E-value: 1.51e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 626 NQLKQVFINILKNAIEVMPGGGNIYVTIQpSDQDHILISFQDEGTGISEDKLKRLGEPFYT-----TKDRGTGLGLMVSY 700
Cdd:cd16975     3 LLLSRALINIISNACQYAPEGGTVSISIY-DEEEYLYFEIWDNGHGFSEQDLKKALELFYRddtsrRSGGHYGMGLYIAK 81

                          90
                  ....*....|...
gi 1101469627 701 KIIEEHQGRIHVE 713
Cdd:cd16975    82 NLVEKHGGSLIIE 94

KinE

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...

16-154

1.88e-10

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 63.84 E-value: 1.88e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  16 QLKRMKEEndrLKSDLNRYHVIMNNTLDAIFICRKEMKIVQANEAAARMMQIEAESLINRSVLDFLYSVPQEELNKAVKK 95
Cdd:COG5809   128 ERKRMEEA---LRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDDQENVAAFISQ 204

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1101469627  96 FLK-KGHLWKEVPIKLDSGATKYIEF----LARDGIgEDYFFVVMRDISSKKILEREFSMNEQL 154
Cdd:COG5809   205 LLKdGGIAQGEVRFWTKDGRWRLLEAsgapIKKNGE-VDGIVIIFRDITERKKLEELLRKSEKL 267

PRK11107

hybrid sensory histidine kinase BarA; Provisional

625-731

2.29e-10

hybrid sensory histidine kinase BarA; Provisional

Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 64.10 E-value: 2.29e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 625 PNQLKQVFINILKNAIEVMPGGG-NIYVTIQPSDQDHILISFQ--DEGTGISEDKLKRLGEPF------YTTKDRGTGLG 695
Cdd:PRK11107  406 PLRLQQIITNLVGNAIKFTESGNiDILVELRALSNTKVQLEVQirDTGIGISERQQSQLFQAFrqadasISRRHGGTGLG 485

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1101469627 696 LMVSYKIIEEHQGRIHVESEEGKGTVFHLTLPIRQN 731
Cdd:PRK11107  486 LVITQKLVNEMGGDISFHSQPNRGSTFWFHLPLDLN 521

HATPase_DpiB-CitA-like

cd16915

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

634-727

2.45e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.

Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 58.07 E-value: 2.45e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 634 NILKNAIEVM----PGGGNIYVTIQpSDQDHILISFQDEGTGISEDKLKRLGEPFYTTK---DRGTGLGLMVSYkiIEEH 706
Cdd:cd16915     7 NLIDNALDALaatgAPNKQVEVFLR-DEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKgqgERGIGLALVRQS--VERL 83

                          90       100
                  ....*....|....*....|.
gi 1101469627 707 QGRIHVESEEGKGTVFHLTLP 727
Cdd:cd16915    84 GGSITVESEPGGGTTFSIRIP 104

PAS

PAS domain [Signal transduction mechanisms];

384-512

2.52e-10

PAS domain [Signal transduction mechanisms];

Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 61.58 E-value: 2.52e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 384 RMEKELRESELKFRKVFNGSMDGKVLFDNQFRIIDANPLASRILGMPDEELRAYTVPDILSLFDIENAGVPARKIDLEGM 463
Cdd:COG2202     1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAALAGGG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1101469627 464 DNEIPFLLSSSDSRKLEFSFKRNIIQNMN------LAIFKDVTEAKELEERLRKS 512
Cdd:COG2202    81 VWRGELRNRRKDGSLFWVELSISPVRDEDgeitgfVGIARDITERKRAEEALRES 135

PRK11086

sensory histidine kinase DcuS; Provisional

494-727

2.66e-10

sensory histidine kinase DcuS; Provisional

Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 63.39 E-value: 2.66e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 494 AIFKDVTEAKELEERLrkSDTLHVVGELAAGiAHEIRNPMTALKGFIQLLQGSIEGEYSL-----YFNVITSELKRIES- 567
Cdd:PRK11086  318 ATFRDKTEVRQLAQRL--DGMVNYADALRAQ-SHEFMNKLHVILGLLHLKSYDQLEDYILktannYQEEIGSLLGKIKSp 394

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 568 IITEFLiLAKpqailyeekdvtqiMKDTADLlnaqanlvNVQIHLNLTGNIPPiyCEPNQLKQVFI----NILKNAIEVM 643
Cdd:PRK11086  395 VIAGFL-LGK--------------ISRAREL--------GITLIISEDSQLPD--SGDEDQVHELItilgNLIENALEAV 449

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 644 PG--GGNIYVTIQPSDqDHILISFQDEGTGISEDKLKRLGEPFYTTKDRGTGLGLMVSYKIIEEHQGRIHVESEEGKGTV 721
Cdd:PRK11086  450 GGeeGGEISVSLHYRN-GWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQ 528


                  ....*.
gi 1101469627 722 FHLTLP 727
Cdd:PRK11086  529 FFVQIP 534

HATPase_EnvZ-like

cd16950

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

628-727

1.53e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.

Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 55.53 E-value: 1.53e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 628 LKQVFINILKNAIEVmpGGGNIYVTIQpSDQDHILISFQDEGTGISEDKLKRLGEPFYTTKD----RGTGLGLMVSYKII 703
Cdd:cd16950     1 LKRVLSNLVDNALRY--GGGWVEVSSD-GEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNargtSGTGLGLAIVQRIS 77

                          90       100
                  ....*....|....*....|....
gi 1101469627 704 EEHQGRIHVESEEGKGTVFHLTLP 727
Cdd:cd16950    78 DAHGGSLTLANRAGGGLCARIELP 101

HATPase_VanS-like

cd16923

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

628-727

1.53e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.

Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 55.86 E-value: 1.53e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 628 LKQVFINILKNAIEVMPGGGNIYVTIQPSDqDHILISFQDEGTGISEDKLKRLGEPFY----TTKDRGTGLGLMVSYKII 703
Cdd:cd16923     1 LQRVFSNLLSNAIKYSPENTRIYITSFLTD-DVVNIMFKNPSSHPLDFKLEKLFERFYrgdnSRNTEGAGLGLSIAKAII 79

                          90       100
                  ....*....|....*....|....
gi 1101469627 704 EEHQGRIHVESeEGKGTVFHLTLP 727
Cdd:cd16923    80 ELHGGSASAEY-DDNHDLFKVRLP 102

YesM

COG2972

Sensor histidine kinase YesM [Signal transduction mechanisms];

634-731

1.81e-09

Sensor histidine kinase YesM [Signal transduction mechanisms];

Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 60.42 E-value: 1.81e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 634 NILKNAIEVMPGGGNIYVTIQpSDQDHILISFQDEGTGISEDKLKRLGEPFyTTKDRGTGLGLMVSYKIIEEHQG---RI 710
Cdd:COG2972   347 NAIEHGIEPKEGGGTIRISIR-KEGDRLVITVEDNGVGMPEEKLEKLLEEL-SSKGEGRGIGLRNVRERLKLYYGeeyGL 424

                          90       100
                  ....*....|....*....|.
gi 1101469627 711 HVESEEGKGTVFHLTLPIRQN 731
Cdd:COG2972   425 EIESEPGEGTTVTIRIPLEEE 445

PRK10337

sensor protein QseC; Provisional

526-719

1.95e-09

sensor protein QseC; Provisional

Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 60.43 E-value: 1.95e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 526 AHEIRNPMTALK------------------GFIQLLQGsIEGEYSLYFNVITseLKRIESiitefliLAKPQailyeekD 587
Cdd:PRK10337  245 AHELRSPLAALKvqtevaqlsdddpqarkkALLQLHAG-IDRATRLVDQLLT--LSRLDS-------LDNLQ-------D 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 588 VTQIMkdTADLL---------NAQANLVNVQIHLNLTGNIPPIycEPNQLKQVFINILKNAIEVMPGGGNIYVTIQPSdq 658
Cdd:PRK10337  308 VAEIP--LEDLLqsavmdiyhTAQQAGIDVRLTLNAHPVIRTG--QPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR-- 381

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1101469627 659 dhiLISFQDEGTGISEDKLKRLGEPFYTTKDR---GTGLGLMVSYKIIEEHQGRIHVESEEGKG 719
Cdd:PRK10337  382 ---NFTVRDNGPGVTPEALARIGERFYRPPGQeatGSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442

sensory_box

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...

272-389

2.54e-09

Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 55.76 E-value: 2.54e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 272 SEERFREIFENAMDAIVIWSDDGKIAKANESACRIFELPMDKLLETNLCTFIVDPQKKYKQIKKKYEKYGEI---REEML 348
Cdd:TIGR00229   1 SEERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEEDREEVRERIERRLEGEPepvSEERR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1101469627 349 FQMANGQYKELEFTSKRTILEGQH---LTILRNVSDRKRMEKEL 389
Cdd:TIGR00229  81 VRRKDGSEIWVEVSVSPIRTNGGElgvVGIVRDITERKEAEEAL 124

PRK10755

two-component system sensor histidine kinase PmrB;

522-732

3.06e-08

two-component system sensor histidine kinase PmrB;

Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 56.13 E-value: 3.06e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 522 AAGIAHEIRNPMTALKGFIQLL--QGSIEgeyslyfnvITSELKRIESI---ITEFLILAKP-QAI---LYEE----KDV 588
Cdd:PRK10755  141 TADVAHELRTPLAGIRLHLELLekQHHID---------VAPLIARLDQMmhtVEQLLQLARAgQSFssgHYQTvkllEDV 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 589 TQIMKDTADLLNAQAnlvnvQIHLNLTGNIPPIYCEPNQ--LKQVFINILKNAIEVMPGGGNIYVTIQpSDQDHILISFQ 666
Cdd:PRK10755  212 ILPSQDELSEMLEQR-----QQTLLLPESAADITVQGDAtlLRLLLRNLVENAHRYSPEGSTITIKLS-QEDGGAVLAVE 285

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1101469627 667 DEGTGISEDKLKRLGEPFYTTKDR--GTGLGLMVSYKIIEEHQGRIHVES-EEGKGTVFHLTLPIRQNT 732
Cdd:PRK10755  286 DEGPGIDESKCGELSKAFVRMDSRygGIGLGLSIVSRITQLHHGQFFLQNrQERSGTRAWVWLPKAQNV 354

PAS

PAS domain [Signal transduction mechanisms];

16-147

3.25e-08

PAS domain [Signal transduction mechanisms];

Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 55.42 E-value: 3.25e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  16 QLKRMKEEndrLKSDLNRYHVIMNNTLDAIFICRKEMKIVQANEAAARMMQIEAESLINRSVLDFLYSVPQEELNKAVKK 95
Cdd:COG2202   124 ERKRAEEA---LRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRR 200

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1101469627  96 FLKKGHLWKEVPIKLDSGATKYIEF-----LARDGIGEDYFFVVMRDISSKKILERE 147
Cdd:COG2202   201 LLEGGRESYELELRLKDGDGRWVWVeasavPLRDGGEVIGVLGIVRDITERKRAEEA 257

HATPase_PhoQ-like

cd16954

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

611-726

5.03e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.

Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 52.25 E-value: 5.03e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 611 HLNLTGNIPPIYC---EPNQLKQVFINILKNAIEVmpGGGNIYVTIQPsDQDHILISFQDEGTGISEDKLKRLGEpfytt 687
Cdd:cd16954    18 GVSISLDISPELRfpgERNDLMELLGNLLDNACKW--CLEFVEVTARQ-TDGGLHLIVDDDGPGVPESQRSKIFQ----- 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1101469627 688 kdRGT---------GLGLMVSYKIIEEHQGRIHVESEEGKGTVFHLTL 726
Cdd:cd16954    90 --RGQrldeqrpgqGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135

HATPase_LytS-like

cd16957

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

630-727

6.60e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.

Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 51.27 E-value: 6.60e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 630 QVFI-NILKNAIEVMPGGGNIYVTIQPsDQDHILISFQDEGTGISEDKLKRLGEPFYTTKdRGTGLGLmvsYKIIEE--- 705
Cdd:cd16957     7 QVLVeNAIRHAFPKRKENNEVRVVVKK-DQHKVHVSVSDNGQGIPEERLDLLGKTTVTSE-KGTGTAL---ENLNRRlig 81

                          90       100
                  ....*....|....*....|....*
gi 1101469627 706 ---HQGRIHVESEEGKGTVFHLTLP 727
Cdd:cd16957    82 lfgSEACLHIESEVHGGTEVWFVIP 106

PAS_4

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...

43-139

3.12e-07

Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 49.33 E-value: 3.12e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  43 DAIFICRKEMKIVQANEAAARMMQIEAESLINRSVLDFLYSVPQEELNKAVKKFLKKGHLWKEVPIKLDSGATKYIEFLA 122
Cdd:pfam08448   6 DALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPEDAARLERALRRALEGEEPIDFLEELLLNGEERHYELRL 85

                          90       100
                  ....*....|....*....|.
gi 1101469627 123 ---RDGIGE-DYFFVVMRDIS 139
Cdd:pfam08448  86 tplRDPDGEvIGVLVISRDIT 106

sensory_box

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...

152-269

5.25e-07

Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 49.21 E-value: 5.25e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 152 EQLFKDLFDRAVDGIVLFDKDGGFIDANLSFCKSFEIGQNELSHLSLRHFTDGENKKHLKE-IWETLRRKGNAKGELPVK 230
Cdd:TIGR00229   2 EERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEEDREEVRErIERRLEGEPEPVSEERRV 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1101469627 231 LRS-GEEKLFEFTITSNLISG---FYMSIMRDITEKRLMELKL 269
Cdd:TIGR00229  82 RRKdGSEIWVEVSVSPIRTNGgelGVVGIVRDITERKEAEEAL 124

sensory_box

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...

392-509

8.04e-07

Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 48.44 E-value: 8.04e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 392 SELKFRKVFNGSMDGKVLFDNQFRIIDANPLASRILGMPDEELRAYTVPDILSLFDIE-NAGVPARKIDLEGMDNEIPFL 470
Cdd:TIGR00229   1 SEERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEEDREeVRERIERRLEGEPEPVSEERR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1101469627 471 LSSSDSRKLEFSFK-RNIIQNMN----LAIFKDVTEAKELEERL 509
Cdd:TIGR00229  81 VRRKDGSEIWVEVSvSPIRTNGGelgvVGIVRDITERKEAEEAL 124

PRK13560

hypothetical protein; Provisional

127-728

1.47e-06

hypothetical protein; Provisional

Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 51.60 E-value: 1.47e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 127 GEDYFFVVMRDISSKKILEREFSMNEQLFKDLFDRAVDGIVLFDKDGGFIDANLSFCKSFEIGQNELSHLSLRHFTDGEN 206
Cdd:PRK13560  178 ADDQVDGFAEDITERKRAEERIDEALHFLQQLLDNIADPAFWKDEDAKVFGCNDAACLACGFRREEIIGMSIHDFAPAQP 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 207 KKHLKEI-WETLRRKGNAKGELPVKLRSGEEKLFE-------FTITSNLISGFYMSIMrDITEKRLMELKLFKSEERFRE 278
Cdd:PRK13560  258 ADDYQEAdAAKFDADGSQIIEAEFQNKDGRTRPVDvifnhaeFDDKENHCAGLVGAIT-DISGRRAAERELLEKEDMLRA 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 279 IFENAMDAIVIWSDDGKIAKANESACRIF-----ELPMDKLL-----ETN---------LCTFIVDPQKKYKQIKKKYEK 339
Cdd:PRK13560  337 IIEAAPIAAIGLDADGNICFVNNNAAERMlgwsaAEVMGKPLpgmdpELNeefwcgdfqEWYPDGRPMAFDACPMAKTIK 416

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 340 YGEIRE--EMLFQMANGQYKELE-FTSKRTILEGQ---HLTILRNVSDRKRMEKELRESELkfrKVFNGSMdgkVLFdnQ 413
Cdd:PRK13560  417 GGKIFDgqEVLIEREDDGPADCSaYAEPLHDADGNiigAIALLVDITERKQVEEQLLLANL---IVENSPL---VLF--R 488

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 414 FRIIDANP--LASRIL---GMPDEELRAYTVP--DILSLFDIENAGVPARKIDLEGMD---NEIPFLLSS------SDSR 477
Cdd:PRK13560  489 WKAEEGWPveLVSKNItqfGYEPDEFISGKRMfaAIIHPADLEQVAAEVAEFAAQGVDrfeQEYRILGKGgavcwiDDQS 568

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 478 KLEFSFKRNIIQNMNLAIfkDVTEAKELEERLRKSDTLHVVgeLAAGIAHEIRNPMTALKGFIQLLQGSIEGEYSLyfNV 557
Cdd:PRK13560  569 AAERDEEGQISHFEGIVI--DISERKHAEEKIKAALTEKEV--LLKEIHHRVKNNLQIISSLLDLQAEKLHDEEAK--CA 642

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 558 ITSELKRIESiitefLILAKPQaiLYEEKDVTQImkdtaDLLNAQANLVNvqiHLNLTGNIP--PIYCEPN------QLK 629
Cdd:PRK13560  643 FAESQDRICA-----MALAHEK--LYQSEDLADI-----DFLDYIESLTA---HLKNSFAIDfgRIDCKIDaddgclDID 707

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 630 QV------FINILKNAIE-VMPGG--GNIYVTIQPSDQDHILISFQDEGTGISEDKLKRLGEPfyttkdrgtgLGLMVSY 700
Cdd:PRK13560  708 KAipcgliISELLSNALKhAFPDGaaGNIKVEIREQGDGMVNLCVADDGIGLPAGFDFRAAET----------LGLQLVC 777

                         650       660
                  ....*....|....*....|....*...
gi 1101469627 701 KIIEEHQGRIHVESEegKGTVFHLTLPI 728
Cdd:PRK13560  778 ALVKQLDGEIALDSR--GGARFNIRFPM 803

PAS

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

274-323

1.73e-06

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.

Pssm-ID: 214512 Cd Length: 67 Bit Score: 45.85 E-value: 1.73e-06

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1101469627  274 ERFREIFENAMDAIVIWSDDGKIAKANESACRIFELPMDKLLETNLCTFI 323
Cdd:smart00091   1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELI 50

HATPase_CheA-like

cd16916

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...

659-727

4.92e-06

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.

Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 47.58 E-value: 4.92e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 659 DHILISFQDEGTGISEDKLKR------------------------LGEPFYTTKDR-----GTGLGLMVSYKIIEEHQGR 709
Cdd:cd16916    81 NQVVIEVSDDGRGIDREKIREkaierglitadeaatlsddevlnlIFAPGFSTAEQvtdvsGRGVGMDVVKRSIESLGGT 160

                          90
                  ....*....|....*...
gi 1101469627 710 IHVESEEGKGTVFHLTLP 727
Cdd:cd16916   161 IEVESEPGQGTTFTIRLP 178

PAS

pfam00989

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...

32-138

4.95e-06

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 45.87 E-value: 4.95e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  32 NRYHVIMNNTLDAIFICRKEMKIVQANEAAARMMQIEAESLINRSVLDFLYSVPQEELNKAVKKFLKKGHLWK--EVPIK 109
Cdd:pfam00989   1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQALLQGEESRgfEVSFR 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1101469627 110 LDSGATKYIEFLA---RDGIGE-DYFFVVMRDI 138
Cdd:pfam00989  81 VPDGRPRHVEVRAspvRDAGGEiLGFLGVLRDI 113

RocR

COG3829

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...

265-395

5.11e-06

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];

Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 49.77 E-value: 5.11e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 265 MELKLFKSEERFREIFENAMDAIVIWSDDGKIAKANESACRIFELPMDKLLETNLCTFIvdpqkkYKQIKKKYEKYGEiR 344
Cdd:COG3829     2 EELELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELI------PNSPLLEVLKTGK-P 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1101469627 345 EEMLFQMANGQYKELEFTSKRTILEGQH---LTILRNVSDRKRMEKELRESELK 395
Cdd:COG3829    75 VTGVIQKTGGKGKTVIVTAIPIFEDGEVigaVETFRDITELKRLERKLREEELE 128

ComP

COG4585

Signal transduction histidine kinase ComP [Signal transduction mechanisms];

596-730

7.85e-06

Signal transduction histidine kinase ComP [Signal transduction mechanisms];

Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 48.08 E-value: 7.85e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 596 ADLLNAQANLVNVQIHLNLTGNIPPIycePNQLKQVFI--------NILKNAievmpGGGNIYVTIQPSDqDHILISFQD 667
Cdd:COG4585   130 EELAERLLRAAGIRVELDVDGDPDRL---PPEVELALYrivqealtNALKHA-----GATRVTVTLEVDD-GELTLTVRD 200

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1101469627 668 EGTGISEDKLKRlgepfyttkdRGTGLGLMVSykIIEEHQGRIHVESEEGKGTVFHLTLPIRQ 730
Cdd:COG4585   201 DGVGFDPEAAPG----------GGLGLRGMRE--RAEALGGTLTIGSAPGGGTRVRATLPLAA 251

HATPase_RstB-like

cd16939

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

628-727

9.31e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.

Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 45.11 E-value: 9.31e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 628 LKQVFINILKNAIEVMPGGGNIYVTIQpsdQDHILISFQDEGTGISEDKLKRLGEPFY---TTKDRGT---GLGLMVSYK 701
Cdd:cd16939     1 MARALDNLLRNALRYAHRTVRIALLVS---GGRLTLIVEDDGPGIPAAARERVFEPFVrldPSRDRATggfGLGLAIVHR 77

                          90       100
                  ....*....|....*....|....*.
gi 1101469627 702 IIEEHQGRIHVESEEGKGTVFHLTLP 727
Cdd:cd16939    78 VALWHGGHVECDDSELGGACFRLTWP 103

COG3920

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...

365-730

1.09e-05

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];

Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 48.75 E-value: 1.09e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 365 RTILEGQHLTILRNVSDRKRMEKELRESELKFRKVFNGSMDGKVLFDNQFRIIDANPLASRILGMPDEELRAYTVPDILS 444
Cdd:COG3920   138 LLLLAILALAELAVALAELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLL 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 445 LFDIENAGVPARKIDLEGMDNEIPFLLSSSDSRKLEFSFKRNIIQNMNL------AIFKDVTEAKELEERLRKSD----- 513
Cdd:COG3920   218 LLLALLLVLLAALLRLRAAVLEELERRRRARGLGRLLLLLLLLLLLLRAllllaaGIRLVITERKRAEEELEASLeekel 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 514 -----------TLHVVGELAAGIAHEIRNPmtALKGFIQLLQGsiegeyslyfnvitselkRIESIiteflilAKPQAIL 582
Cdd:COG3920   298 llrelhhrvknNLQVVSSLLRLQARRADDP--EAREALEESQN------------------RIQAL-------ALVHELL 350

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 583 YEEKDVTQImkDTADLLNAQANLV-----NVQIHLNLTGniPPIYCEPNQLKQV-------FINILKNAIEVMPGGgNIY 650
Cdd:COG3920   351 YQSEDWEGV--DLRDYLRELLEPLrdsygGRGIRIELDG--PDVELPADAAVPLglilnelVTNALKHAFLSGEGG-RIR 425

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 651 VTIQPSDqDHILISFQDEGTGISEDklkrlgepfyTTKDRGTGLGLMVSYKIIEEHQGRIHVESEEgkGTVFHLTLPIRQ 730
Cdd:COG3920   426 VSWRRED-GRLRLTVSDNGVGLPED----------VDPPARKGLGLRLIRALVRQLGGTLELDRPE--GTRVRITFPLAE 492

CheA

COG0643

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];

659-728

1.37e-05

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];

Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 48.25 E-value: 1.37e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 659 DHILISFQDEGTGISEDKLKR------------------------LGEPFYTTKDR-----GTGLGLMVSYKIIEEHQGR 709
Cdd:COG0643   320 GRVVIEVSDDGRGLDLEKIRAkaiekglitaeeaaalsdeellelIFAPGFSTAEEvtdlsGRGVGMDVVKTNIEALGGT 399

                          90
                  ....*....|....*....
gi 1101469627 710 IHVESEEGKGTVFHLTLPI 728
Cdd:COG0643   400 IEIESEPGKGTTFTLRLPL 418

RocR

COG3829

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...

385-511

6.10e-05

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];

Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 46.30 E-value: 6.10e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 385 MEKELRESELKFRKVFNGSMDGKVLFDNQFRIIDANPLASRILGMPDEELRAYTVPDILSLFDIENA---GVPARKIDLE 461
Cdd:COG3829     2 EELELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPNSPLLEVlktGKPVTGVIQK 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1101469627 462 GMDNEIPFLLSSS---DSRKLEFSfkrniiqnmnLAIFKDVTEAKELEERLRK 511
Cdd:COG3829    82 TGGKGKTVIVTAIpifEDGEVIGA----------VETFRDITELKRLERKLRE 124

RocR

COG3829

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...

22-153

6.10e-05

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];

Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 46.30 E-value: 6.10e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  22 EENDRLKSDLNRYHVIMNNTLDAIFICRKEMKIVQANEAAARMMQIEAESLINRSVLDFLYsvpqeelNKAVKKFLKKGH 101
Cdd:COG3829     1 AEELELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIP-------NSPLLEVLKTGK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1101469627 102 LWKEVPIKLDSGATKYIefLARDGIGED----YFFVVMRDISSKKILEREFSMNEQ 153
Cdd:COG3829    74 PVTGVIQKTGGKGKTVI--VTAIPIFEDgeviGAVETFRDITELKRLERKLREEEL 127

PAS_8

pfam13188

PAS domain; PAS domains are involved in many signalling proteins where they are used as a ...

32-90

2.73e-04

PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 39.84 E-value: 2.73e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1101469627  32 NRYHVIMNNTLDAIFICRKEMKIVQANEAAARMMQIEAESLINRSVLDFLYSVPQEELN 90
Cdd:pfam13188   1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELLDLLDPLLEDALE 59

PAS

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

33-95

3.51e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.

Pssm-ID: 214512 Cd Length: 67 Bit Score: 39.30 E-value: 3.51e-04

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1101469627   33 RYHVIMNNTLDAIFICRKEMKIVQANEAAARMMQIEAESLINRSVLDFLYSVPQEELNKAVKK 95
Cdd:smart00091   2 RLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQR 64

HATPase_YpdA-YehU-LytS-like

cd16924

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

618-727

3.53e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 40.51 E-value: 3.53e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 618 IPPIYCEPnqlkqvfinILKNAIE--VMPGGGNIYVTIQPSDQD-HILISFQDEGTGISEDKLKRLGEpfytTKDRGTGL 694
Cdd:cd16924     1 IPPFTLQP---------LVENAIQhgLSPLTDKGVVTISALKEDnHVMIEVEDNGRGIDPKVLNILGK----KPKEGNGI 67

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1101469627 695 GLM-VSYKIIEE--HQGRIHVESEEGKGTVFHLTLP 727
Cdd:cd16924    68 GLYnVHQRLILLfgEDYGIHIASEPDKGTRITFTIP 103

PAS

cd00130

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

43-138

3.58e-04

Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 40.31 E-value: 3.58e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  43 DAIFICRKEMKIVQANEAAARMMQIEAESLINRSVLDFLYSVPQEELNKAVKKFLKKGHLWK-EVPIKLDSGATKYIEF- 120
Cdd:cd00130     3 DGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTlEVRLRRKDGSVIWVLVs 82

                          90       100
                  ....*....|....*....|.
gi 1101469627 121 ---LARDGIGEDYFFVVMRDI 138
Cdd:cd00130    83 ltpIRDEGGEVIGLLGVVRDI 103

PAS_8

pfam13188

PAS domain; PAS domains are involved in many signalling proteins where they are used as a ...

274-307

4.00e-04

Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 39.07 E-value: 4.00e-04

                          10        20        30
                  ....*....|....*....|....*....|....
gi 1101469627 274 ERFREIFENAMDAIVIWSDDGKIAKANESACRIF 307
Cdd:pfam13188   1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELL 34

PAS_4

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...

159-263

5.24e-04

Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 40.09 E-value: 5.24e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 159 FDRAVDGIVLFDKDGGFIDANLSFCKSFEIGQNELSHLSLRHFTDGENKKHLKEIWETLRRKGNAKGELPVKLRSGEEKL 238
Cdd:pfam08448   1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPEDAARLERALRRALEGEEPIDFLEELLLNGEERH 80

                          90       100
                  ....*....|....*....|....*....
gi 1101469627 239 FEFTITSNL-ISG---FYMSIMRDITEKR 263
Cdd:pfam08448  81 YELRLTPLRdPDGeviGVLVISRDITERR 109

HATPase_UhpB-NarQ-NarX-like

cd16917

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

634-727

5.70e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.

Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 39.46 E-value: 5.70e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 634 NILKNAievmpGGGNIYVTIQpSDQDHILISFQDEGTGISEDklkrlgepfytTKDRGTGLGLMvsykIIEEH----QGR 709
Cdd:cd16917    11 NALKHA-----GASRVRVTLS-YTADELTLTVVDDGVGFDGP-----------APPGGGGFGLL----GMRERaellGGT 69

                          90
                  ....*....|....*...
gi 1101469627 710 IHVESEEGKGTVFHLTLP 727
Cdd:cd16917    70 LTIGSRPGGGTRVTARLP 87

PRK13560

hypothetical protein; Provisional

11-173

7.98e-04

hypothetical protein; Provisional

Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 42.74 E-value: 7.98e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  11 ESLKEQLKRMKEENDRLKSDLNRYHVIMNNTLDAIFICRKEMKIVQANEAAARMMQIEAESLINRSVLDFLYSVPQEELN 90
Cdd:PRK13560  183 DGFAEDITERKRAEERIDEALHFLQQLLDNIADPAFWKDEDAKVFGCNDAACLACGFRREEIIGMSIHDFAPAQPADDYQ 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627  91 KA-VKKFLKKGHLWKEVPIKLDSGATKYIE--FLARDGIGEDY----FFVVMRDISSKKILEREFSMNEQLFKDLFDRAV 163
Cdd:PRK13560  263 EAdAAKFDADGSQIIEAEFQNKDGRTRPVDviFNHAEFDDKENhcagLVGAITDISGRRAAERELLEKEDMLRAIIEAAP 342

                         170
                  ....*....|
gi 1101469627 164 DGIVLFDKDG 173
Cdd:PRK13560  343 IAAIGLDADG 352

HATPase_PDK-like

cd16929

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...

621-720

8.80e-04

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.

Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 40.79 E-value: 8.80e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 621 IYCEPNQLKQVFINILKNAIE------------VMPgggnIYVTIQpSDQDHILISFQDEGTGISEDKLKRLGEPFYTTK 688
Cdd:cd16929    37 FPYVPSHLYYILFELLKNAMRatveshgddsddLPP----IKVTVA-KGDEDLTIKISDRGGGIPREDLARLFSYMYSTA 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1101469627 689 DR-------------------GTGLGLMVSYKIIEEHQGRIHVESEEGKGT 720
Cdd:cd16929   112 PQpslddfsdlisgtqpsplaGFGYGLPMSRLYAEYFGGDLDLQSMEGYGT 162

PAS

pfam00989

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...

274-385

1.55e-03

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 38.94 E-value: 1.55e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101469627 274 ERFREIFENAMDAIVIWSDDGKIAKANESACRIFELPMDKLLETNLCTFIVDPQKKYKQIkkkyekygEIREEML-FQMA 352
Cdd:pfam00989   1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAE--------LLRQALLqGEES 72

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1101469627 353 NGQYKELEFTSKRTILEGQHLTILRNVSDRKRM 385
Cdd:pfam00989  73 RGFEVSFRVPDGRPRHVEVRASPVRDAGGEILG 105

PAS

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

395-449

2.27e-03

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.

Pssm-ID: 214512 Cd Length: 67 Bit Score: 36.99 E-value: 2.27e-03

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1101469627  395 KFRKVFNGSMDGKVLFDNQFRIIDANPLASRILGMPDEELRAYTVPDILSLFDIE 449
Cdd:smart00091   2 RLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRE 56

PAS_4