N-acetylglucosamine repressor [Providencia rettgeri]
Protein Classification
ROK family protein( domain architecture ID 11449187)
ROK (Repressor, ORF, Kinase) family protein functions as a sugar kinase or may act as a transcriptional regulator involved in carbohydrate-dependent transcriptional control
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| ASKHA_ATPase_ROK_Mlc | cd24074 | ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ... |
30-351 | 2.27e-157 | ||||||
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. : Pssm-ID: 466924 [Multi-domain] Cd Length: 322 Bit Score: 444.06 E-value: 2.27e-157
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| Name | Accession | Description | Interval | E-value | ||||||
| ASKHA_ATPase_ROK_Mlc | cd24074 | ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ... |
30-351 | 2.27e-157 | ||||||
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466924 [Multi-domain] Cd Length: 322 Bit Score: 444.06 E-value: 2.27e-157
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| NagC | COG1940 | Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ... |
29-325 | 2.68e-34 | ||||||
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription]; Pssm-ID: 441543 [Multi-domain] Cd Length: 306 Bit Score: 128.09 E-value: 2.68e-34
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| ROK | pfam00480 | ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ... |
34-288 | 5.66e-13 | ||||||
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif. Pssm-ID: 395384 [Multi-domain] Cd Length: 292 Bit Score: 68.52 E-value: 5.66e-13
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| Name | Accession | Description | Interval | E-value | ||||||
| ASKHA_ATPase_ROK_Mlc | cd24074 | ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ... |
30-351 | 2.27e-157 | ||||||
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466924 [Multi-domain] Cd Length: 322 Bit Score: 444.06 E-value: 2.27e-157
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| ASKHA_ATPase_ROK_NagC | cd24075 | ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ... |
32-345 | 1.08e-47 | ||||||
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466925 [Multi-domain] Cd Length: 315 Bit Score: 163.69 E-value: 1.08e-47
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| NagC | COG1940 | Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ... |
29-325 | 2.68e-34 | ||||||
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription]; Pssm-ID: 441543 [Multi-domain] Cd Length: 306 Bit Score: 128.09 E-value: 2.68e-34
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| ASKHA_NBD_ROK_TM1224-like | cd24059 | nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ... |
34-326 | 1.73e-27 | ||||||
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members. Pssm-ID: 466909 [Multi-domain] Cd Length: 305 Bit Score: 109.60 E-value: 1.73e-27
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| ASKHA_ATPase_ROK_CYANR | cd24073 | ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ... |
33-321 | 7.76e-23 | ||||||
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466923 [Multi-domain] Cd Length: 304 Bit Score: 96.85 E-value: 7.76e-23
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| ASKHA_NBD_ROK_BsGLK-like | cd24062 | nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ... |
71-325 | 5.02e-19 | ||||||
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466912 [Multi-domain] Cd Length: 311 Bit Score: 86.19 E-value: 5.02e-19
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| ASKHA_ATPase_ROK_Lmo0178-like | cd24071 | ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ... |
32-325 | 2.80e-17 | ||||||
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466921 [Multi-domain] Cd Length: 312 Bit Score: 81.18 E-value: 2.80e-17
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| ASKHA_ATPase_ROK_BsXylR-like | cd24076 | ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ... |
50-325 | 2.67e-15 | ||||||
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes. Pssm-ID: 466926 [Multi-domain] Cd Length: 303 Bit Score: 75.29 E-value: 2.67e-15
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| ASKHA_NBD_ROK_FnNanK-like | cd24068 | nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ... |
68-325 | 2.75e-15 | ||||||
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families. Pssm-ID: 466918 [Multi-domain] Cd Length: 294 Bit Score: 75.29 E-value: 2.75e-15
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| ROK | pfam00480 | ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ... |
34-288 | 5.66e-13 | ||||||
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif. Pssm-ID: 395384 [Multi-domain] Cd Length: 292 Bit Score: 68.52 E-value: 5.66e-13
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| ASKHA_ATPase_ROK_YphH-like | cd24072 | ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ... |
74-332 | 1.88e-12 | ||||||
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466922 [Multi-domain] Cd Length: 308 Bit Score: 67.05 E-value: 1.88e-12
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| ASKHA_NBD_ROK_TmGLK-like | cd24064 | nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ... |
35-330 | 1.18e-10 | ||||||
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466914 [Multi-domain] Cd Length: 301 Bit Score: 61.74 E-value: 1.18e-10
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| ASKHA_ATPase_ROK_SaXylR-like | cd24077 | ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ... |
33-325 | 1.40e-09 | ||||||
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members. Pssm-ID: 466927 [Multi-domain] Cd Length: 295 Bit Score: 58.32 E-value: 1.40e-09
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| ASKHA_ATPase_ROK | cd23763 | ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ... |
42-166 | 9.01e-09 | ||||||
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains. Pssm-ID: 466849 [Multi-domain] Cd Length: 239 Bit Score: 55.16 E-value: 9.01e-09
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| ASKHA_NBD_ROK_ApGLK-like | cd24063 | nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ... |
67-325 | 1.63e-08 | ||||||
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466913 [Multi-domain] Cd Length: 308 Bit Score: 55.04 E-value: 1.63e-08
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| ASKHA_NBD_ROK_SgGLK-like | cd24061 | nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ... |
64-300 | 1.24e-06 | ||||||
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466911 [Multi-domain] Cd Length: 306 Bit Score: 49.27 E-value: 1.24e-06
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| ASKHA_NBD_ROK_EcFRK-like | cd24066 | nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ... |
203-298 | 6.28e-05 | ||||||
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466916 [Multi-domain] Cd Length: 294 Bit Score: 44.12 E-value: 6.28e-05
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| ASKHA_NBD_ROK_EcNanK-like | cd24069 | nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ... |
37-287 | 3.71e-04 | ||||||
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466919 [Multi-domain] Cd Length: 283 Bit Score: 41.89 E-value: 3.71e-04
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| ASKHA_NBD_ROK-like | cd24152 | nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ... |
51-311 | 1.50e-03 | ||||||
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families. Pssm-ID: 466988 [Multi-domain] Cd Length: 286 Bit Score: 39.86 E-value: 1.50e-03
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| ASKHA_NBD_ROK_AlsK | cd24070 | nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ... |
203-287 | 3.84e-03 | ||||||
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466920 [Multi-domain] Cd Length: 293 Bit Score: 38.68 E-value: 3.84e-03
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| ASKHA_NBD_ROK_NAGK | cd24057 | nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ... |
203-287 | 8.81e-03 | ||||||
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Pssm-ID: 466907 [Multi-domain] Cd Length: 298 Bit Score: 37.60 E-value: 8.81e-03
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