|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
11-393 |
0e+00 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 536.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 11 LLVILATVTLDSVGLGLVLPVLPSLIRELT-HTTDVAGHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAV 89
Cdd:cd17388 1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVgDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 90 DYTVMAFTTSLPILYLGRIVAGITGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVGAISPRYPFLA 169
Cdd:cd17388 81 DYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 170 AAVFNGLNFLLGWFVLPESHLAEKQPLHIT-HLNPFRSLWWVFGIKAILPLLLVYSVISCVAQVPATIWVIYGEDRYAWG 248
Cdd:cd17388 161 AAGLNGLNFLLGLFVLPESLPPERRRAFRWrRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 249 TRMVGLTFAVFGVMYGLSQAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILLAAGGIAMPALQALL 328
Cdd:cd17388 241 PTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLL 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1133582698 329 SKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYAQTSGLWPGFVWICGAVVYLLCFPALGFEF 393
Cdd:cd17388 321 SRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLAWIIGAALYLICLVLAYRFF 385
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
14-391 |
3.14e-73 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 232.47 E-value: 3.14e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 14 ILATVTLDSVGLGLVLPVLPSLIRELTHTTDVAGHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTV 93
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 94 MAFTTSLPILYLGRIVAGITGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVGAISP-RYPFLAAAV 172
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGyALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 173 FNGLNFLLGWFVLPeshlaekqplhithlnpfrslwwvfgikAILPLLLVYSVISCVAQVPATIWVIYGEDRYAWGTRMV 252
Cdd:cd17330 161 LALLNLVLVLFFLP----------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQI 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 253 GLTFAVFGVMYGLSQAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALAT-QGWMVFPVMILLAAGGIAMPALQALLSKQ 331
Cdd:cd17330 213 GLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASsVPLLVLAAAILAFGTGIVFPALSALLSKS 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 332 VDEGKQGELQGTLVSVMSLASIVGPVVVTTVYaqtSGLWPGFVWICGAVVYLLCFPALGF 391
Cdd:cd17330 293 VPSKEQGKAQGIIQSLQSLARIIGPLLAGPLY---SFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-391 |
5.49e-52 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 178.15 E-value: 5.49e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 14 ILATVTLDSVGLGLVLPVLPSLIRELtHTTDVAGhfGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTV 93
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESL-GASVAQI--GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 94 MAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVV-GAISPRYPFLAAA 171
Cdd:cd17325 78 FAFATSYWQLLLARFLQGLaSAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLaDALGYRAPFLVCA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 172 VFNGLNFLLGWFVLPESHLAEKQPlHITHLNPFRSLWWVFGIKAILPLLLVYSVISCVAQVPATIWVIYGEDRYAWGTRM 251
Cdd:cd17325 158 ALALLALVLALLLLPEPRPPPNKR-AVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 252 VGLTFAVFGVMYGLSQaFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILLAAG-GIAMPALQALLSK 330
Cdd:cd17325 237 IGLLFGAQGLASALSQ-PPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGlGLVFPATLALLAD 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1133582698 331 QVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYAQTSGLWPgfvWICGAVVYLLCFPALGF 391
Cdd:cd17325 316 IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATP---FLAAAALLLLAAVLFLL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-352 |
3.74e-45 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 159.37 E-value: 3.74e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 3 PRKSVGRPLLVILATVTLDSVGLGLVLPVLPSLIRELTHTTDVAGhfgYFLAAYALMQFLFSPILGALSDRYGRRPVLLV 82
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAG---LVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 83 SLAGAAVDYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVG-A 160
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAdL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 161 ISPRYPFLAAAVFNGLNFLLGWFVLPESHLAEKQPLHithlnpfRSLWWVFGIKAILPLLLVYSVISCVAQVPATIWVIY 240
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLR-------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 241 GEDRYAWGTRMVGLTFAVFGVMYGLSQaFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILLAAG-GI 319
Cdd:COG2814 234 LQEVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGL 312
|
330 340 350
....*....|....*....|....*....|...
gi 1133582698 320 AMPALQALLSKQVDEGKQGELQGTLVSVMSLAS 352
Cdd:COG2814 313 LFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
20-358 |
8.00e-44 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 155.85 E-value: 8.00e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 20 LDSVGLGLVLPVLPSLIRELTHTTDVAGHFGyflAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTS 99
Cdd:cd17390 7 LDLFGVSMILPLLSTHIRSLGASPTVIGLIG---SVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 100 LPILYLGRIVAGITGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVGAIS--PRYPFLAAAVFNGLN 177
Cdd:cd17390 84 LALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDggFYYVALLCSAIFILN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 178 FLLGWFVLPEshlaekqplhithlnpfrsLWWVFGIKAILPL--LLVYSVIScvaqvpatiwvIYGEDRYAWGTRMVGLT 255
Cdd:cd17390 164 AGLVWFLLSK-------------------LWDLLLVRFLMGFsvLLFRSNFS-----------LYLEERFDLSPKTIGYL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 256 FAVFGVMYGLSQaFLTGWMSKRWG--DRRSLLLALIADNLGFVGMALATQGWMVFPVMILLA-AGGIAMPALQALLSKQV 332
Cdd:cd17390 214 ISYSGVLGALSG-FLVGRILKLYKnnEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSiSSAVLRTCSTSLLLSRG 292
|
330 340
....*....|....*....|....*.
gi 1133582698 333 DEGKQGELQGTLVSVMSLASIVGPVV 358
Cdd:cd17390 293 KSKERGTLLGVGQSVTSLARILAPLL 318
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
10-386 |
4.26e-43 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 154.68 E-value: 4.26e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 10 PLLVILATVTLDSVGLGLVLPVLPSLIRELThttDVAGHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAV 89
Cdd:cd17331 1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLG---VDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 90 DYTVMAFTTSLPILYLGRIVAgITGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVV-GAISPRYPFL 168
Cdd:cd17331 78 SYLLLAFASSVPMLFLSRLPS-VFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLtKKFGEQAAAL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 169 AAAVFNGLNFLLGWFVLPESHLAEKQPLH--------------ITHLNPFRSLWWVFGIKAI--LPLLLVYSVISCVAQv 232
Cdd:cd17331 157 VAAVGSLLSIVLVILLIPSNTKSKREKEAkesasppsvfnlkeILRLLRLPGVAFLLLVKLLsgLPIGMFQSMFSLVAM- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 233 patiwviygeDRYAWGTRMVGLTFAVFGVMYGLSQAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMI 312
Cdd:cd17331 236 ----------DFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLL 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1133582698 313 LLAAGG-IAMPALQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYAQTSglWPGFVWICGAVVYLLCF 386
Cdd:cd17331 306 PLVIGGsVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYG--FPSFGLLGAAINGLLTV 378
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
12-386 |
6.90e-32 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 124.22 E-value: 6.90e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 12 LVILATVTLDSV-GLGLVLPVLPSLIRELTHTTDVAGhfgYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVD 90
Cdd:cd17474 1 LYAVFFATLLAVlGVSIVDPILPAIAEALGASPAQVG---LLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 91 YTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVGAISPRYPFLA 169
Cdd:cd17474 78 GLLCGLSDSFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 170 AAVFNGLNFLLGWFVLPESHLAEKQPLHITHLNPFRSL----WWVFGIKAILPLLLVYSVISCVAQVPatiwviygEDRY 245
Cdd:cd17474 158 LAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALrgrgLLTFLVSAFLYFFLYFAFLTYLPFLL--------ELLY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 246 AWGTRMVGLTFAVFGVMYGLSQAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALAT-QGWMVFPVMILLAAGGIAMPAL 324
Cdd:cd17474 230 GISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPsLALLLIAIVLFGLGLGLNLPLL 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1133582698 325 QALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYAQTSglWPGFVWICGAVVYLLCF 386
Cdd:cd17474 310 TTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG--LSAPFLVGAAIALAAAV 369
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
11-379 |
1.22e-31 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 123.45 E-value: 1.22e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 11 LLVILATVTLDSVGLGLVLPVLPSLIReltHTTDVAGHF-GYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAV 89
Cdd:cd17473 1 LITLLLASTLTVMAGAAIAPALPAIAQ---HFVPNSELLvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 90 DYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVGAISPRYPFL 168
Cdd:cd17473 78 GGVAGLFLDSLYALLASRALLGIgVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 169 AAAvFNGLNFLLGWFVLPESHLAEKQPLHIT----HLNPFRSLWWVFGIkAILPLLLVYSViscVAQVPATIwviygEDR 244
Cdd:cd17473 158 VYL-LALPVLILVLLFLPEPARKSKSAASPGaataAALPWKRVLPIYFL-AFLAMLLFYVI---PIQLPFLL-----QER 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 245 YAWGTRMVGLTFAVFGVMYGLSqAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILLAAG-GIAMPA 323
Cdd:cd17473 228 GGGSAALIGLALAIASLAGAIG-ALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGfGLLLPT 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1133582698 324 LQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYAQTSGLWPGFVWICGA 379
Cdd:cd17473 307 LNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVL 362
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
11-381 |
5.00e-30 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 119.25 E-value: 5.00e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 11 LLVILATVTLDSVGLGLVLPVLPSLIRELTHTTdvAGHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVD 90
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLS--ASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 91 YTVMAFTTSLPILYLGRIVAGITGA-NMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVGAISPRYPFLA 169
Cdd:cd17329 79 FALLGFAHSPWLFAIALVLTGFGGGlFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 170 AAVFNGLNFLLGWFVLPESHLAEKQPlhiTHLNPFRSLWWVFGIKAILPLLLVYSVISCVAQVPATIWVIYGEDRYAWGT 249
Cdd:cd17329 159 AAVLFLLAALVLLFLLPETRPKRRAA---EKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGE 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 250 RMVGLTFAVFGVMYGLSQAFLTGWMsKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILLAAGGIAM-PALQALL 328
Cdd:cd17329 236 SLLGLLLALNALLIVLLQFPVARLV-ERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVfPAVQTLV 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1133582698 329 SKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYAQTSGLWPgfVWICGAVV 381
Cdd:cd17329 315 AALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLP--WLILAALG 365
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-356 |
6.57e-30 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 118.29 E-value: 6.57e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 14 ILATVTLDSVGLGLVLPVLPSLIRELTHTTdvAGHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTV 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGIS--PTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 94 MAFTTSLPILYLGRIVAGIT-GANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGG-VVGAISPRYPFLAAA 171
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGlLASLFGWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 172 VFNGLNFLLGWFVLPEShlAEKQPLHITHLNPFRSLWWVFGIKAILPLLLVYSVISCVAQVPATIWVIYGEDRYAWGTRM 251
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPP--ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 252 VGLTFAVFGVMyGLSQAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALA----TQGWMVFPVMILLAAGGIAMPALQAL 327
Cdd:pfam07690 237 AGLLLGLGGLL-GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLsltlSSLWLLLALLLLGFGFGLVFPALNAL 315
|
330 340
....*....|....*....|....*....
gi 1133582698 328 LSKQVDEGKQGELQGTLVSVMSLASIVGP 356
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
11-363 |
8.95e-29 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 115.83 E-value: 8.95e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 11 LLVILATVTLDSVGLGLVLPVLPSLIR--------ELTHTTDVAGH------------------FGYFL-AAYALMQFLF 63
Cdd:cd17389 1 ITIVFLALLLDLLAFTIILPLFPSLLDyygqnddsGLYSLQISSVDwfrdaigapderrynsvlFGGLIgSLFSLLQFLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 64 SPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGITGANMAVATAYLADISDESERAQRYGYMNAC 143
Cdd:cd17389 81 SPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 144 FGIGFVAGPLLGGV-------VGAISPRYPFLAAAVFNGLNFLLGWFVLPEshlaekqplhiTHLNPFRSLWWVFGIKAI 216
Cdd:cd17389 161 FSLGFIIGPMIGAYfasftrsLGEVFFSMPALFALVLALADLLFIFFFLPE-----------TLPSNLRRLGLVYFLYLF 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 217 LPLLLVYSVISCVAQvpatiwviygedRYAWGTRMVGLTFAVFGVMYGLSQAfltGWMSKR--WGDRRSLLLALIADNLG 294
Cdd:cd17389 230 LFSGLEFTLTFLTHQ------------RFQYTSMQQGKMFFFIGIIMALVQG---GYVRRIkpGKEKKAVLQGLILLIPA 294
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 295 FVGMALATQGWMVFPVMILLA-AGGIAMPALQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVY 363
Cdd:cd17389 295 FLLIGWASSVTVLYAGLFLYSfAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVY 364
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
50-188 |
1.21e-28 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 109.28 E-value: 1.21e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 50 GYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGITGA-NMAVATAYLADIS 128
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAfALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1133582698 129 DESERAQRYGYMNACFGIGFVAGPLLGGVVGAISP-RYPFLAAAVFNGLNFLLGWFVLPES 188
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGwRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
22-358 |
1.78e-27 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 111.97 E-value: 1.78e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 22 SVGLGLVLPVLPSLIRELTHTT--DVAGHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTS 99
Cdd:cd17391 9 GIGFSLIAPFLPLYIEQLGVTSggLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTN 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 100 LPILYLGRIVAGITGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVV-GAISPRYPFLAAAVFNGLNF 178
Cdd:cd17391 89 VWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLaDLFGIRNVFFITGGLLFLAF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 179 LLGWFVLPESHLAEKQPLHITHLNPFRSLWWVFGIKAILPLLLVYSVISCVAQVPATIWVIYGEDRYAWGTRMVGLTFAV 258
Cdd:cd17391 169 LLTLFFVKEDFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 259 FGVMYGLSQAFLtGWMSKRWGDRRSLLLALIADNLGFVGMALATQGW--MVFPVMILLAAGGIaMPALQALLSKQVDEGK 336
Cdd:cd17391 249 TGVSSLLSAPRL-GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWqlGILRFLLGLATGGL-LPAINSLLAKITPKEV 326
|
330 340
....*....|....*....|..
gi 1133582698 337 QGELQGTLVSVMSLASIVGPVV 358
Cdd:cd17391 327 AGRIFGYNQSFQYLGNVAGPLL 348
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
24-386 |
1.38e-26 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 109.22 E-value: 1.38e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 24 GLGLVLPVLPSLIRELTHTTDVAGhfgYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPIL 103
Cdd:cd17489 11 SFYLLLPVLPLYAHDLGGSEAVAG---LVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 104 YLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGG-VVGAISPRYPFLAAAVFNGLNFLLG 181
Cdd:cd17489 88 LVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLfLYQHLGFAVLFIVAAVLALLALLLV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 182 WFVLPESHLAEKQPLHITHLNPFRSLWWVFGIKAILPLL-LVYSVIScvaqvpaTIWVIYGEDRYAWGTrmvGLTFAVFG 260
Cdd:cd17489 168 FLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLAsIAYGAIS-------TFLPLYAAERGISNA---GLFFTVYA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 261 VMYGLSqAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILLAAG-GIAMPALQALLSKQVDEGKQGE 339
Cdd:cd17489 238 IALLLS-RPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPALQALAVDLVPPHRRGA 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1133582698 340 LQGTLVSVMSLASIVGPVVVTTVYAQTSglwPGFVWICGAVVYLLCF 386
Cdd:cd17489 317 ANGTFFIFFDLGIGLGGLLLGLVAELFG---YRAMFLLAAVVVLLAL 360
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
26-389 |
2.17e-26 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 109.05 E-value: 2.17e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 26 GLVLPVLPSLIRELTHTTDVAGhfgYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYL 105
Cdd:cd06174 13 GLISPLLPALLQSFGLSASQLG---LLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 106 GRIVAGITGANMAVAT-AYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVGAISP---RYPFLAAAVFNGLNFLLG 181
Cdd:cd06174 90 GRFLLGLGSGLIDPAVlALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfgwRAVFLIAAALALLAAILL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 182 WFVLPESHLAEKQPLH-ITHLNPFRSLWWVFGIKAILPLLLVYSVISCVAQVPATIWVIYGEDRYAWGTRMVGLTFAVFG 260
Cdd:cd06174 170 LLVVPDPPESARAKNEeASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 261 VMYGLSQAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILLAAG-GIAMPALQALLSKQVDEGKQGE 339
Cdd:cd06174 250 LAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGlGGLLPLSFALIAELFPPEIRGT 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1133582698 340 LQGTLVSVMSLASIVGPVVVTTVYAQTSGLwpGFVWICGAVVYLLCFPAL 389
Cdd:cd06174 330 AFGLLNTFGFLGGAIGPLLAGFLLAATFGL--TGAFLVLAVLLLLAAILL 377
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
13-381 |
2.18e-25 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 106.14 E-value: 2.18e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 13 VILATVTLDSVGLGLVLPVLPSLIRELTHTTDvAGHFGYFLAAYALMQFLFSPILGALSDRYG-RRPVLLVSLAGAAVDY 91
Cdd:cd17326 3 VMYLTMFLSSLQFSIVLTSIWPYLQKIDPTAT-ASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVGN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 92 TVMAFTTSLP-----ILYLGRIVAGITGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLG---------GV 157
Cdd:cd17326 82 ILYALAEYFPsnrkyVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQaaftpigypGY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 158 VGAISPRY-----PFLAAAVFNGLNFLLGWFVLPEshlaekqplhithlnpfrslwwvfgikaiLPLLLVYSVISCVAQV 232
Cdd:cd17326 162 VIGIKLRFnmytaPAWLMAILGIINIILILFFFKE-----------------------------VVCIFLFFVVLFIFAN 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 233 PATIWVIYGEDRYAWG----TRMVGLTFAVFGVmYGLSQAFLTGWMSKR-WGDRRSLLLALIadnLGFVGMaLATQGWMV 307
Cdd:cd17326 213 LETIGTPLTMDMYGWTreeaVLYNGIILAVSGV-LSVLVFLLFKFLSLGlIDERKILLGGLI---LFFLGF-VVTLPWGI 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1133582698 308 FPVMILlaagGIAMP----ALQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYaQTSGLWPGFVWICGAVV 381
Cdd:cd17326 288 TGVILF----GLGYPignvMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIY-THFGPRWTWIITLGLLL 360
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
11-388 |
1.25e-24 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 104.19 E-value: 1.25e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 11 LLVILATVTLDSVGLGLVLPVLPSLIREL-THTTDVAGHFGYFLAAYALMQFLFspilGALSDRYGRRPVLLVSLAGAAV 89
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLgASASAVQLTLSAYLLGFALGQLLY----GPLSDRFGRRPVLLAGLLLFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 90 DYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVGAI-SPRYPF 167
Cdd:cd17320 77 ASLLCALASSIEQLLIARFLQGLgAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFfGWRAIF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 168 LAAAVFNGLNFLLGWFVLPESHLAEK-----QPLHITHLNPFRSLwwVFGIKAILPLLLVYSVISCVAQVPatiwVIYGE 242
Cdd:cd17320 157 VFLALLGLLLLLLVLLFLPETLPEEKrkpllSSLLRAYKRVLKNR--RFLGYALALGLSFAGLFAYLAAAP----FIYIE 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 243 dRYAWGTRMVGLTFAVFGVMYGLSqAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQG------WMVFPVMILLAA 316
Cdd:cd17320 231 -QLGLSPAQFGLLFALNAIALILG-SLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLgglslwPLVAPLFLIFFG 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1133582698 317 GGIAMPALQALLSKQVDE--GKQGELQGTLvsVMSLASIVGPvVVTTVYAQTSGLWPGFVWICGAVVYLLCFPA 388
Cdd:cd17320 309 FGLIFPNATSLALEPFPHvaGTASALLGFL--QFLIGALAGA-LVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
30-381 |
2.32e-24 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 103.01 E-value: 2.32e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 30 PVLPSLIRELTHTTDVAGHFgyfLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIV 109
Cdd:cd17324 20 GLLPDIARDFGVSVAQAGLL---VSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 110 AGIT-GANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVG-AISPRYPFLAAAVFNGLNFLLGWFVLPE 187
Cdd:cd17324 97 AGLAhGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGqLLGWRAAFLAIAVLALLAALLLWRLLPS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 188 ShlaekQPLHITHLNPFRSLWWVFGIKAILPLLLVYSVISCVAQVPATIWVIYGEDRYAWGTRMVGLTFAVFGVMyGLSQ 267
Cdd:cd17324 177 L-----PPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVA-GVVG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 268 AFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILLAAGGIAMPALQALLSKQVDEGKQGELQGTLVSV 347
Cdd:cd17324 251 SPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAA 330
|
330 340 350
....*....|....*....|....*....|....
gi 1133582698 348 MSLASIVGPVVVTTVYAQTSglWPGFVWICGAVV 381
Cdd:cd17324 331 YNLGGALGAALGGLVLDHGG--WAGVGWVGAALL 362
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
52-386 |
1.82e-22 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 97.73 E-value: 1.82e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 52 FLAAYALMQFLF----SPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPI------LYLGRIVAGITGANMAV-- 119
Cdd:cd17386 31 FYLYMNLMGSIPplfsSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIVYFTTvpsvwwFYLSAIPLALFGGFTAFls 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 120 -ATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVV-GAISPRYPFLAAAVFNGLNFLLGWFVLpeshlaekqplh 197
Cdd:cd17386 111 aSFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLfKALGYAWSFSISAALLLIALLYILFFL------------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 198 ithlnpfrslwwvfgiKAILPLLLVYSVISCVAQVPATIWVIYGEDRYAWGTRMVGL--TFAVFGVMYGLSQAFLTGWMS 275
Cdd:cd17386 179 ----------------TLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYfsTLGSLIYLTGMLGGVLLLRCL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 276 KRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILLAAGGIAMPALQALLSKQVDEGKQGELQGTLVSVMSLASIVG 355
Cdd:cd17386 243 LKMSDSTLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSVLESLSPLVA 322
|
330 340 350
....*....|....*....|....*....|.
gi 1133582698 356 PVVVTTVYAQTSGLWPGFVWICGAVVYLLCF 386
Cdd:cd17386 323 SPIYNNIYKATLTTFPGFFFLLSAGLLLIPV 353
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
14-389 |
3.11e-22 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 97.30 E-value: 3.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 14 ILATVTLDSVGLGLVLPVLPSLIRELTHTtdvAGHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTV 93
Cdd:cd06173 4 LWLAQLLSALGDWIFTVALPWLVLQLTGS---ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 94 MAFTT-----SLPILYLGRIVAGITGA-NMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGV-VGAISPRYP 166
Cdd:cd06173 81 LALLAllgslSLWLLLVLAFLLGIASAfFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLlVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 167 FLAAAVFNGLNFLLGWFVLPESHLAEKQPLHITHLNPFRSLWWVFGIKAILPLLLVYSVISCVAQVPATIWVIYGEDRYA 246
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 247 WGTRMVGLTFAVFGVMYGLSqAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILL-AAGGIAMPALQ 325
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALLG-ALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLgLAGGLFNVPLN 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1133582698 326 ALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYAQTSglWPGFVWICGAVVYLLCFPAL 389
Cdd:cd06173 320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALG--LSAVFLLAGALLLLAALLLL 381
|
|
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
58-363 |
1.35e-21 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 95.95 E-value: 1.35e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 58 LMQFLFSPILGALSDRYGRRPVLLVSLagaavdytvmaFTTSLPILYLgRI----------VAGITGANMAVATAYLADI 127
Cdd:cd17387 47 ILSFLSAPLIGALSDVWGRKSFLLLTV-----------FFTCAPIPLM-RIspwwyfamisVSGIFSVTFSVIFAYVADI 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 128 SDESERAQRYGYMNACFGIGFVAGPLLGGvvgAISPRYP----FLAAAVFNGLNFLLGWFVLPEShLAEK-------QPL 196
Cdd:cd17387 115 TTEEERSTAYGLVSATFAASLVTSPALGA---YLSESYGdnlvVLVATIVALLDICFILLAVPES-LPEKmrpaswgAPI 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 197 HITHLNPFRSLWWVFGIKAILPL-LLVYSVISCVAQVPATIWViYGEDRYAWGTRMVGLTFAVFGVMYGLSQAFLTGWMS 275
Cdd:cd17387 191 SWEQADPFASLRKVGKDKTVLLIcITVFLSYLPEAGQYSSFFV-YLKQVMGFEYEEVAAFIAVVGILSITAQTLLLSILM 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 276 KRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILLAAGGIAMPALQALLSKQVDEGKQGELQGTLVSVMSLASIVG 355
Cdd:cd17387 270 RSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISALVSRYADPDQQGAVQGMITGIRGLCNGLG 349
|
....*...
gi 1133582698 356 PVVVTTVY 363
Cdd:cd17387 350 PALFGFVF 357
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
3-386 |
2.47e-21 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 94.92 E-value: 2.47e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 3 PRKSVGRPLLVILATVTLDSVGLGLVLPVLPSLIRELTHTTDVAGhfgYFLAAYALMQFLFSPILGALSDRYGRRPVLLV 82
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAG---LLLFAFFLGYLLASLPAGRLIDRFGYKRGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 83 SLAGAAVDYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESeRAQRYGYMNACFGIGFVAGPLLGGVV--- 158
Cdd:COG0738 79 GLLLMALGLLLFALAPSYPLLLLALFLLGLgLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLill 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 159 -GAISPRYPFLAAAVFNGLNFLLGWFvlpeSHLAEKQPLHITHLNPFRSLWWVFGIKAILpLLLVYSVISCVAQVPATIW 237
Cdd:COG0738 158 gLSLSWHLPYLILAVLLLLLALLFLR----SKLPEIEEEEEEAAGSAASLKSLLKNPRLL-LGGLAIFLYVGAEGAIGDW 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 238 VI-YGEDRYAWGTRMVGLTFAVFGVMYGLSQaFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILLAA 316
Cdd:COG0738 233 LPlYLKDVLGLSEATAALGLSLFWGGMTIGR-FLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGL 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1133582698 317 G-GIAMPALQALLSKQVdeGKQGELQGTLVSVMS-LASIVGPVVVTTVyAQTSGLWPGFVWICGAVVYLLCF 386
Cdd:COG0738 312 GlSLMFPTIFSLALDGL--GKRTAAAVSAVLIMGiVGGAIGPPLIGFL-ADAFGLRAAFLVPLVCYLLILLL 380
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
49-386 |
4.77e-20 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 91.10 E-value: 4.77e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 49 FGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGIT-GANMAVATAYLADI 127
Cdd:COG2223 42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGgGGSFAVGIALVSKW 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 128 SDESERAQRYGYMNACFGIG-FVAGPLLGGVVGAISPRYPFLAAAVFNGLNFLLGWFVLPESHLAEKQPlhitHLNPFRS 206
Cdd:COG2223 122 FPPDRRGLALGLAAGGGNLGaAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAA----AKASLRD 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 207 LWWVFGIKAILPLLLVYSVISCVAQVPATIWVIYGEDRYAWGTRMVGLTFAVFGVMYGLSQaFLTGWMSKRWGDRRSLLL 286
Cdd:COG2223 198 QLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGR-PLGGWLSDRIGGRRVLLI 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 287 ALIADNLGFVGMALATQGWMVFPVMILL--AAGGIAMPALQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYA 364
Cdd:COG2223 277 VFALMALGLLLLALALGSLWLFLVLFLLlgLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLD 356
|
330 340
....*....|....*....|..
gi 1133582698 365 QTSGLWPGFvwICGAVVYLLCF 386
Cdd:COG2223 357 ATGSYTAAF--LVFAVLALVAL 376
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
14-332 |
1.79e-19 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 89.14 E-value: 1.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 14 ILATVTLDSVGLGLVLPVLPS-LIRELTHTtdvAGHFGYFLAAYALMQFLFSPILGALSDR-YGRRPVLLVSLAGAAVDY 91
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLfLTEELGAS---PLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 92 TVMAFTTS-LPILYLGRIVAGITGANMAVATAYLADISDESERAQRYGYMN---ACFGIGFVAGPLLGG-VVGAISPRYP 166
Cdd:cd17471 78 LLFAFLRNyWVLLLVGVVLLSLGAAAFPQLFALAREYADRSSGRDATLFNSvlrAAFSLAWVIGPPLAFlLLDVLGFTGL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 167 FLAAAVFNGLNFLLGWFVLPEShlaeKQPLHITHLNPFRSLWWVfgIKAILPLLLVYSVISCVAQvpatiwvIYGEDRYA 246
Cdd:cd17471 158 FLLAALLYLVVALLVLFLLPSV----KPPAQKATPASSLVKAPV--NRRLLLLFAAFTLLFAANS-------MYIIAMPL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 247 WGTRMVGLTFAVFGVMYGLSQAF------LTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILLAAG--- 317
Cdd:cd17471 225 YVTNELGGSESWVGLLFGLAAALeipimlLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFigi 304
|
330
....*....|....*..
gi 1133582698 318 --GIAMPALQALLSKQV 332
Cdd:cd17471 305 taGLGISYFQDLMPGQP 321
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
3-275 |
2.69e-18 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 84.48 E-value: 2.69e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 3 PRKSVGRPLLVILATVTLDSVGLGLVLPVLPSLIRELTHTTDvagHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLV 82
Cdd:COG0477 8 PTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSA---QLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 83 SLAGAAVDYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGV-VGA 160
Cdd:COG0477 85 GLLLFGLASLLCGLAPSPELLIAARALQGIgAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLlVAA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 161 ISPRYPFLAAAVFNGLNFLLGWFvLPESHLAEKQPLHITHLNPFRSLWWVFGIKAILPLLLVYSVISCVAQVPATIWVIY 240
Cdd:COG0477 165 LGWRWIFLINAPLGLLALVLRLR-LPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLL 243
|
250 260 270
....*....|....*....|....*....|....*
gi 1133582698 241 GEDRYAWGTRMVGLTFAVFGVMYGLSQAFLTGWMS 275
Cdd:COG0477 244 ALLLLALLLLLALLLLAALLLLLLLLLLLALLLAL 278
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-381 |
7.99e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 84.15 E-value: 7.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 11 LLVILATVTLDSVGLGLVLPVLPSLIRELTHTtdvAGHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVD 90
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLS---AAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 91 YTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGG-VVGAISPRYPFL 168
Cdd:COG2271 89 TLLFGFATSFWQLLLLRFLLGLgEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGwLLAAFGWRAAFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 169 AAAVFNGLNFLLgwfvlpeshlaekqplhithlnpfrslwwvfgikAILPLLLVYSVISCVAQVPATIWVIYGEDRYAWG 248
Cdd:COG2271 169 ILGLPGLLLALL----------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLS 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 249 TRMVGLTFAVFGVMYGLSqAFLTGWMSKRWGDRRS--LLLALIADNLGFVGMALATQGWMVFPVMILLAAG-GIAMPALQ 325
Cdd:COG2271 215 LAQAGLLLSLPFLAGIVG-SLLGGWLSDRLGRRRKlvLAIGLLLAALALLLLALLPSPALAIALLFLAGFGlGGAFGLLW 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1133582698 326 ALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYAQTsGLWPGFVWICGAVV 381
Cdd:COG2271 294 ALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLAALAL 348
|
|
| MFS_SLC46A1_PCFT |
cd17449 |
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ... |
62-384 |
8.46e-18 |
|
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 84.86 E-value: 8.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 62 LFSPIL-GALSDRYGRRPVLLVSLAG----AAVDYTVMAFTTSLPILYLGRIVAGITG---ANMAVATAYLADISDESER 133
Cdd:cd17449 79 LFSVTLlGPWSDSVGRRPVLILPSLGlalqAAVYLLVMYLQLHVAYFLIGRILSGLLGdfnGILAGCFAYVADVSDRRSR 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 134 AQRYGYMNACFGIGFVAGPLLGG----VVGAISPRYPFLAAAVFNGlnfLLGWFVLPESHLAEKQPLHIT--HLNPFRSL 207
Cdd:cd17449 159 TFRVAVLEACLGLAGMLASIIGGqwrkAQGYINPFWLVLALNLAAA---LYAAFCVGESVKEPKSARLFTtrHHQSVVRL 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 208 WWVFGIKAILPLLLVYS----VISCVAQVPATIWVIYG-EDRYAWGTRMVGLTFAVFGVMYGLSQAFLTgWMSKRWGDRR 282
Cdd:cd17449 236 YVAPAPNGSRRKLALYSlalfVVVTVHFGAKDLLVLYElSSPLCWDSDLIGYGSAAEHLTYLSSLLGLR-LLQLCLEDTW 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 283 SLLLALIADNLGFVGMALATQGWMVFPVMILLAAGGIAMPALQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTV 362
Cdd:cd17449 315 VAEIGLISNISGLVVISVATTTPLMFTGYGLLFLSMATTPVIRAKLSKLVRETEQGALFASVACVEGLCSLVATGIFNSL 394
|
330 340
....*....|....*....|..
gi 1133582698 363 YAQTSGLWPGFVWICGAVVYLL 384
Cdd:cd17449 395 YPATLHFMKGFPFLFGAALLLI 416
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
14-397 |
1.62e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 83.38 E-value: 1.62e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 14 ILATVTLDSVGLGLVLPVLPSLIRELTHTTDVAGhfgYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTV 93
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQ---WVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 94 MAFTTSLPILYLGRIVAGITGAN-MAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVGAisprypflaaav 172
Cdd:cd17321 78 CALAPSLAFLIAARALQGIGAAAiMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE------------ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 173 fnglnfLLGWfvlpeshlaekqplhithlnpfRSLWWVFGIKAILPLLL--------VYSVISCVAQVPATIWV-IYGED 243
Cdd:cd17321 146 ------LFGW----------------------RWIFLINVPIGLVALLLartfsgavLAAFLLGAALGGLLFLLpLYLQG 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 244 RYAWGTRMVGLTFAVFGVMYGLSqAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQG---WMVFPVMILLAAG-GI 319
Cdd:cd17321 198 VLGYSPLQAGLALLPLALAMLVA-APLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADssvWLLLPGLVLLGLGlGL 276
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1133582698 320 AMPALQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYAQTSGLWPGFVWICGAVVYLLCFPALGFEFALAA 397
Cdd:cd17321 277 FATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGDSGVAALLSAAAAAFAAGFHLAFLV 354
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
14-384 |
3.34e-17 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 82.22 E-value: 3.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 14 ILATVTLDSVGLGLVLPVLPSLIRELTHTTDVAGhfgYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTV 93
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIG---LVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 94 MAFTTSLPILYLGRIVAGITGANMAVAT-AYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVGAISPRyPFLAAAV 172
Cdd:cd17477 78 LALTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL-PFLIAAV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 173 FnglnFLLGWFVLPESHLAEKQPLHITHLNPFRSLWwvfgikaILPLLLVYSVISCVAQVPA-TIWVIYGEdRYAWGTRM 251
Cdd:cd17477 157 L----LLLALVPLLLTRRAAPEIEEAESISLRRLLR-------IAPLALLGAFVAGFLEGAFySLLPLYGL-RLGLSVAQ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 252 VGLTFAVFGVMYGLSQAFLtGWMSKRWGDRRSLLLALIADNLGFVGMALA-TQGWMVFPVMILLAAGGIAMPALQ-ALLS 329
Cdd:cd17477 225 AALLLAAFVLGGLLLQWPL-GWLADRFDRRRVLLGCALLGALAALLLPLVpGLPLALLVLLFLWGGAAGPLYTLAlALAG 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1133582698 330 KQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYAQTSGLWPGFVWICGAVVYLL 384
Cdd:cd17477 304 DRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
27-362 |
4.00e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 82.24 E-value: 4.00e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 27 LVLPVLPSLIRELtHTTDVAGhfGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLG 106
Cdd:cd17504 14 MLSPALPTIQREF-GTSAAAV--SWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 107 RIVAGITGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGG-VVGAISPRYPFLAAAVFNGLNFLLGWFVl 185
Cdd:cd17504 91 RALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGwIVQHLGWRWIFWTAAPVAVLLAALVPLI- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 186 PESHLAEKQplhithlnpfrslWWVFGIKAIL---PLLLVYSVISCVAQVPATiwviYGEDRYAWGTRMVGLTFAVFGVM 262
Cdd:cd17504 170 DLRLLRRRN-------------VLLANITALLagfGMFMVFQLLPQLLQLPTP----TGFGLGITEAGLLLLPGALVMLI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 263 YGlsqaFLTGWMSKRWGDRRSLLLALIADNLGFVGMAL-ATQGWMVFPVMILLAAG-GIAMPALQALLSKQVDEGKQGEL 340
Cdd:cd17504 233 AG----PLAGRLIARVGPRRVLLIGLVISAVGLLLLALlHSSLWALVVALLLIGIGlGLAFASLPNIVVESVPPDRTGIA 308
|
330 340
....*....|....*....|..
gi 1133582698 341 QGTLVSVMSLASIVGPVVVTTV 362
Cdd:cd17504 309 TGMNTVLRTIGSAIGPAIAGAI 330
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
49-366 |
6.94e-17 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 81.74 E-value: 6.94e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 49 FGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGITGANMAVAT----AYL 124
Cdd:COG2270 54 WGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLGVLATAALFFVAPGGLWLGLLLFVLANIGFEGSLvfynAFL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 125 ADISDESERAQ------RYGYMNACFG-----IGFVAGPLLGGVVGAISPRYPFLAAAVFNGLNFLLGWFVLPESHLAEK 193
Cdd:COG2270 134 PDIATPEEIGRvsglgwALGYLGGVLLllinlALFLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPERPRPGP 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 194 QPLHITHLNPFRSLWWVFGI----KAILPLLLVYSVISCVAQVPATIWVIYGEDRYAWGTRMVGLTFAVFGVMYGLSqAF 269
Cdd:COG2270 214 APPRGAVRAGFRELRRTLRElrryRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALG-AL 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 270 LTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILLaagGIAMPALQAL----LSKQVDEGKQGELQGTLV 345
Cdd:COG2270 293 LFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLI---GLVMGGIQALsrslLARLIPPGREAEFFGLYA 369
|
330 340
....*....|....*....|.
gi 1133582698 346 SVMSLASIVGPVVVTTVYAQT 366
Cdd:COG2270 370 LSGKAASFLGPLLFGLVTQLT 390
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
10-185 |
1.19e-15 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 77.69 E-value: 1.19e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 10 PLLVILATVTLDSVGLGLVLPVLPSLIRELTHTTDVAGHF-GYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAA 88
Cdd:cd17391 202 LLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFIsGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 89 VDYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVGA-ISPRYP 166
Cdd:cd17391 282 LLYIPQAFVQTPWQLGILRFLLGLaTGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAhFGYRAV 361
|
170
....*....|....*....
gi 1133582698 167 FLAAAVFNGLNFLLGWFVL 185
Cdd:cd17391 362 FVVTALLVLLNAIWSFIFL 380
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
46-352 |
1.31e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 74.94 E-value: 1.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 46 AGHFGYFLAAYALMQFLFSPILGALSDRYG-----RRPVLLVSLAGAAVDYTVMAFTTSLP------ILYLGRIVAGIT- 113
Cdd:COG2211 45 AALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDLSptgkliYALVTYLLLGLAy 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 114 GANMAVATAYLADIS-DESERAQRYGYMNACFGIGFVAGPLLGGVVGAISP-------RYPFLAAAVFNGLNFLLGWFVL 185
Cdd:COG2211 125 TLVNIPYSALGAELTpDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgyRLTALIFAVLGLLAFLLTFFGT 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 186 PESHLAEKQPLHIthlnpFRSLWWVFGIKAILPLLLVYSVISCVAQVPATIWVIYGEDRYAWGTRMVGLTFAVFGVMYGL 265
Cdd:COG2211 205 KERPVPEEEKVSL-----KESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 266 SqAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQG--WMVFPVMILLAAG-GIAMPALQALLSKQVDEG--KQGEL 340
Cdd:COG2211 280 G-APLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGnlWLLLVLAALAGIGlGAILVLPWAMLADVVDYDewKTGRR 358
|
330
....*....|...
gi 1133582698 341 Q-GTLVSVMSLAS 352
Cdd:COG2211 359 ReGLYFGIFTFAI 371
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
2-386 |
4.12e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 73.37 E-value: 4.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 2 NPRKSVGRPLLVILATVTLDSVGLGLVLPVLPSLIRELTHTTDV-AGHFGYFLAAYALMQFLFSPILGALSDRYGRRPVL 80
Cdd:COG2807 7 SARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLsATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 81 LVSLAGAAVDYTVMAFTTSLPILYLGRIVAGITGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGG-VVG 159
Cdd:COG2807 87 LLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVpLAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 160 AISPRYPFLAAAVFNGLNFLLGWFVLPESH-LAEKQPLHITHLNPFRS-LWWVFGIKAILPLLLVYSVISCVAQvpatiw 237
Cdd:COG2807 167 ALGWRGALAVWALLALLALLLWLPLLRRRPaAAAAAPAAASLRSLWRSpLAWLLTLFFGLQSLLYYAVVAWLPP------ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 238 viYGEDRyAWGTRMVGLTFAVFGVMyGLSQAFLTGWMSKRWGDRRSLLLALIADNL-GFVGMALATQGWMVFPVMILLAA 316
Cdd:COG2807 241 --ILRDA-GLSAATAGLLLSLFQLA-GIPGSLLVPLLADRLGDRRPLLLLLGLLGLaGLLGLLLAPGSLPWLWAVLLGLG 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1133582698 317 GGIAMPALQALLSKQVDEGKQ-GELQGTLVSVMSLASIVGPVVVTTVYAQTSGLWPGFVWICGAVVYLLCF 386
Cdd:COG2807 317 QGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVA 387
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
30-383 |
1.03e-13 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 71.87 E-value: 1.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 30 PVLPSLIRELTHTTDVAGhfgYFLAAYALMQFLFSPILGALSDRYGRR-PVLLVSLAGAAVDYTVMAFTTSLPILYLGRI 108
Cdd:cd17490 17 PFLSPYAESLGASLSMIG---IILGAYGISQMLLRIPLGILSDRIGKRkLFIIIGLLFTVLASLIMILFPSPWGLLIARF 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 109 VAGITGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVG-AISPRYPFLAAAVFNGLNFLLGWFVLPE 187
Cdd:cd17490 94 LSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAeHFGMRAPFLLAALAGVLGFILSLFIKEE 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 188 SHLAEKQPlhiTHLNPFRSLwwvfgikAILPLLLVYSVISCVAQVPATIWVIYGEDRYAWGTRM----VGLTFAVFGVMY 263
Cdd:cd17490 174 RREKKPVL---TELKELLSV-------LKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGAssfqLGLLSIIYLLPN 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 264 GLSQAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILL-AAGGIAMPALQALLSKQVDEGKQGELQG 342
Cdd:cd17490 244 ALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNgFGTGILFPLLMSLSIEGVPAEQRSTAMG 323
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1133582698 343 TLVSVMSLASIVGPVVVTTVyAQTSGLWPGFvWICGAVVYL 383
Cdd:cd17490 324 FFQAIYALGMFLGPVLVGII-SEAFGLQTGF-FVIGVIALL 362
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
24-188 |
1.18e-13 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 71.86 E-value: 1.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 24 GLGLVLPVLPSLIRELTHTTDVAghFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPIL 103
Cdd:cd17472 11 GMFLVLPVLSVYAKSLPGATPTL--IGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 104 YLGRIVAGItGANMAVATAYLADISDESERAQRYGYMNACFGI----GFVAGPLLGGVVGAispRYPFLAAAVFNGLNFL 179
Cdd:cd17472 89 ILGRALQGS-GAISSVVMALLADLTREENRTKAMALIGASIGIafaiSMVLGPLLAAHLGV---SGLFLITAILSLVSLL 164
|
....*....
gi 1133582698 180 LGWFVLPES 188
Cdd:cd17472 165 ILLFFVPDP 173
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
49-157 |
1.26e-13 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 71.44 E-value: 1.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 49 FGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGITGAN-MAVATAYLADI 127
Cdd:cd17502 32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGlMSLAFIIIADL 111
|
90 100 110
....*....|....*....|....*....|
gi 1133582698 128 SDESERAQRYGYMNACFGIGFVAGPLLGGV 157
Cdd:cd17502 112 VPPRERGKYQGYIGAVFGIASVAGPLIGGA 141
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
22-362 |
3.88e-12 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 67.27 E-value: 3.88e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 22 SVGLGLVLPVLPSLIRELTHTtdvaghfGYFLAAYALMQFLFSPILGALSDR----YGRR-PVLLVSLAGAAVDYTVMAF 96
Cdd:cd17313 16 ALENSYVPPILQTLGLSHALI-------GFVWTLGPILGLFVQPLVGSLSDRcnsrIGRRrPFILVGAPLAALGLILIPN 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 97 TTSLPILYLGRI--------VAGITGANMAVAT------AYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVGAIS 162
Cdd:cd17313 89 AADIGLALGDGPrtwalvlfVLGIVLLDFAMNVcqgpvrALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHN 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 163 ---------PRYPFLAAAVFNGLNFLLGWFVLPE---------SHLAEKQPLHITHL-----NPFRSLWWV-----FGIK 214
Cdd:cd17313 169 wfgfalggnLKVPFYIGAIILLVCVLVTLFFVKEpplspeageHSENPSLGEVLKSLlkllkIMPRSLLRLllvifFWWI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 215 AILPLLLVYS--VISCVAQVPATIWVIY--GEDRYAWGTRMVGLTFAVFgvmyglsqAFLTGWMSKRWGDRRSLLLALIA 290
Cdd:cd17313 249 AFFPFELFFTdyMGEEVYHGTSAASSHYgaGVRMGAWGLLIFSLAFLIF--------SLPIGKLGKKIGRKKVYLIGLVL 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1133582698 291 DNLGFVGMALATQGWMvfpVMILLAAGGIAMPALQ----ALLSKQVDE--GKQGELQGTLVSVMSLASIVGPVVVTTV 362
Cdd:cd17313 321 FAVGMALMALVHNVTV---ALVLFALGGIGWATINinpyPLVSDYHSEsgRGQGTDTGLLNLAISLAQILVSLLAGPI 395
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
11-185 |
4.26e-12 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 66.85 E-value: 4.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 11 LLVILATVTLDSVGLGLVLPVLPSLIRELTHTtdvagHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVD 90
Cdd:cd17489 196 VLPPALILFLASIAYGAISTFLPLYAAERGIS-----NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALG 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 91 YTVMAFTTSLPILYLGRIVAGIT-GANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVV-GAISPRYPFL 168
Cdd:cd17489 271 LLLLSFAGSPWMLLLAAVLYGLGfGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVaELFGYRAMFL 350
|
170
....*....|....*..
gi 1133582698 169 AAAVFNGLNFLLGWFVL 185
Cdd:cd17489 351 LAAVVVLLALVLYIFLL 367
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
52-180 |
1.04e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 65.64 E-value: 1.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 52 FLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDE 130
Cdd:cd17370 239 LYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLyMGAQESIERAAVADLVPA 318
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1133582698 131 SERAQRYGYMNACFGIG-FVAGPLLGGVVGAISPRYPFLAAAVFNGLNFLL 180
Cdd:cd17370 319 ELRGTAYGLFNTVVGIGwLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
50-385 |
3.70e-11 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 64.14 E-value: 3.70e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 50 GYFLAAYALMQFLFSPILGALSDRYG-RRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGITGANMAVATAYLADIS 128
Cdd:cd17335 35 GILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAQIFWLLLLLVILGAFFSAPVVPLVDSITLQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 129 DESERAQRYG----YMNACFGIG-FVAGPLLGGVVGAISPRYPFLAAAVFNGLNFLLGWFVLPESHLAEKQPlhithlnP 203
Cdd:cd17335 115 YLGEERERYGkqrlWGSIGFGIAaLLVGILIDRSSTYKNYTIAFYVFAVLMLLALLLALKFPFRPKHPEPNE-------N 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 204 FRSLWWVFGIKAILPLLLVYSVISCVAQVPATIWVIYGEDrYAWGTRMVGLTFAVfGVMYGLSQAFLTGWMSKRWGDRRS 283
Cdd:cd17335 188 TGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQD-LGGSKTLIGLLWTV-GVVSEIPFFFFSSRLIQRFGHVGL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 284 LLLALIADNLGFVGMALATQGWMVFPVMILLAAG-GIAMPALQALLSKQVDEGKQGELQGTLVSV-----MSLASIVGPV 357
Cdd:cd17335 266 LYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTfALVWAAAVSYASAAAPPGLRATAQGLLQGLyfglgGGLGSLIGGY 345
|
330 340
....*....|....*....|....*...
gi 1133582698 358 VVTTVYAQTSGLWPGFVWICGAVVYLLC 385
Cdd:cd17335 346 LYEAFGARTTFRFFAIAALAGLLAFFLI 373
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
9-158 |
6.54e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.77 E-value: 6.54e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 9 RPLLVILATVTLDSVGLGLVLPVLPSLIRELTHttDVAGHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAA 88
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYVLG--LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 89 VDYTVMAF--TTSLPILYLGRIVAGIT-GANMAVATAYLADISDESERAQR-------YGYMNACFGIGFVAGPLLGGVV 158
Cdd:COG2211 306 LGLLLLFFlgPGNLWLLLVLAALAGIGlGAILVLPWAMLADVVDYDEWKTGrrreglyFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
55-365 |
2.13e-10 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 61.82 E-value: 2.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 55 AYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGITGANMA-VATAYLADISDESER 133
Cdd:cd17503 39 SYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIpLAQTILLRIYPPEKR 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 134 AQRYGYMNACFGIGFVAGPLLGG-VVGAISPRYPFLAAAVFNGLNFLLGwfvlpeshlaekqplHITHLNPFRSLwwVFG 212
Cdd:cd17503 119 GAAMGLVGLVILLAPAIGPTLGGwLTDNLSWRWIFYINLPIGILALLLA---------------PLLDLRLFKDR--NFT 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 213 IKAILPLLLVYSVISCVAQVPatiwvIYGEDRYAWGTRMVGLTFAVFGVMYGLSqAFLTGWMSKRWGDRRSLLLALIADN 292
Cdd:cd17503 182 LGLLLSFLLGLGLFGAMFLLP-----LYLQNVLGYSAFESGLVLAPGGLASAIL-SPLVGRLLDKFGPRLLLLAGLLLLA 255
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1133582698 293 LGFVGMALATQ----GWMVFPVMILLAAGGIAMPALQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYAQ 365
Cdd:cd17503 256 LGTLLLAFLTPdtslWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTN 332
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
11-381 |
2.86e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 61.46 E-value: 2.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 11 LLVILATVTLDSVGLGLVLPVLPSLIRELTHTTDvAGHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVD 90
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLS-LLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 91 YTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVGAISP-----R 164
Cdd:cd17316 80 TLLIGLLPTPILLLVLRFLQGIgIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgwR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 165 YPFLAAAVFNGLNFLLgwfvlpeshlaekqplhithlnpfrslwwvfgIKAILPLLLVYSVISCVAQVPATIWVIYGEDR 244
Cdd:cd17316 160 ILFLIGALPALLALLL--------------------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTV 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 245 YAWGTRMVGLTFAVFGVMYGLSqAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQG---WMVFPVMILLAAGGIAM 321
Cdd:cd17316 208 LGLSPATSSLYLLLISLGALVG-ALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGsptLLLLLLFILSFFVGGVW 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 322 PALQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYAQTSGLWPGFVWICGAVV 381
Cdd:cd17316 287 GALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAI 346
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
31-184 |
9.10e-10 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 59.89 E-value: 9.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 31 VLPSLIRELTHTTDVAGhfGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTT-SLPILYLGRIV 109
Cdd:COG2223 227 WLPPYLVDQFGLSAATA--GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLL 304
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1133582698 110 AGI-TGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVGAI--SPRYPFLAAAVFNGLNFLLGWFV 184
Cdd:COG2223 305 LGLaLGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtgSYTAAFLVFAVLALVALVLTLLL 382
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
22-389 |
2.09e-09 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 58.78 E-value: 2.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 22 SVGLGLVLPVLPSLIRELTHTTDVAGhFGYFLAAYALMQFLFSPilgaLSDRYG------RRPVLLVSLAGAAVDYTVMA 95
Cdd:cd17485 10 GLPYGFQSQALPVLLRSAGVSLTAIG-LLKLLYLPWVLKFLWAP----LVDRYGlprlgrRRSWLLPTQLGLALLLLALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 96 F---TTSLPILYLGRIVAGITGANMAVAT-AYLADISDESERaqryGYMNACFGIGFVAGPLLGG-----VVGAISPRYP 166
Cdd:cd17485 85 FlppTTNLLAFLGLLFLLNLFSATQDIATdGLAVELLTPEER----GLGNAAQVVGYKLGSLLGGggllwLYDLIGWQSL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 167 FLAAAVFNGLNFLLGWFvLPESHLAEKQPLHITHLNPFRSLWWVFGIKAILPLLLVYSVISCVAQVPATIWVIYGEDRyA 246
Cdd:cd17485 161 LLSLAALYLLLLLPVLF-LRELELPQQPPASERGAALKASLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVDR-G 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 247 WGTRMVGLTFAVFGVMYGLSQAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILLAA-------GGI 319
Cdd:cd17485 239 FSLSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALGGSGLNWVLLLASlallhlvGGM 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 320 AMPALQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVyaqTSGLWPGFVWICGAVVYLLCFPAL 389
Cdd:cd17485 319 ITTALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFL---ADHLGYAAAFLLFAILSALSVLLL 385
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
26-314 |
3.13e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 57.95 E-value: 3.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 26 GLVLPVLPSLIRELTHTTDVAGhfgYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYL 105
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQAG---LLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 106 GRIVAGITGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVGAISPRYPFLAAAVFNGLNFLLGWFVL 185
Cdd:cd17478 90 LVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 186 PESHLAEKQPLHITHLNPFRslwWVFGIKAILPLLLVYSVISCVAQVPATIWVIYGEDRYaWGTRMVGLTFAVFGVMYGL 265
Cdd:cd17478 170 RPLKKPEAKKAAAKSSARST---LKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRG-YSLVFAGLLLSLFLFAGAI 245
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1133582698 266 SQaFLTGWMSKRWGdRRSLLLALIADNLGFVGMALATQGWMVFPVMILL 314
Cdd:cd17478 246 GT-LIGGPLSDRFG-RRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLA 292
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
9-364 |
3.15e-09 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 58.39 E-value: 3.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 9 RPLLVILATVTLDSVGLGLVLPVLPSLIRELTHTTDVAGHF--GYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAG 86
Cdd:PRK09874 14 RNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 87 AAVDYTVMAFTTSLPILYLGRIVAGITGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVG---AISP 163
Cdd:PRK09874 94 MGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLAdsyGLRP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 164 RYPFLAAAVFngLNFLLGWFVLPESH--LAEKQPLHITHL-----NPfrslwwvfgiKAILPLLLVYSVISCVAQVPATI 236
Cdd:PRK09874 174 VFFITASVLF--LCFLVTLFCIRENFqpVSKKEMLHMREVvtslkNP----------KLVLSLFVTTLIIQVATGSIAPI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 237 WVIYGEDRYAWGTRMV---GLTFAVFGVMYGLSQAFLtGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMIL 313
Cdd:PRK09874 242 LTLYVRELAGNVSNIAfisGMIASVPGVAALLSAPRL-GKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFL 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1133582698 314 L-AAGGIAMPALQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYA 364
Cdd:PRK09874 321 LgAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISA 372
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
23-386 |
3.88e-09 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 57.72 E-value: 3.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 23 VGLGLVLPVLPSLIRELTHTTDVAGHFGYFLAAYALMQFLFSpilGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPI 102
Cdd:cd17333 10 LTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLA---GFLMKRLGRRRTLILGLLLISLALALIFATPSIYL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 103 LYLGRIVAGI-TGANMAVATAYLADISDESeRAQRYGYMNACFGIGFVAGPLLGGVVGAISPR--YPFLAAAVFNGLNFL 179
Cdd:cd17333 87 FVVLMFLAGLgAGILDTGANTFVGALFEES-SATRLNVLHGFFGLGALIGPLIATSLLTSELSwsWAYLIIGLIYLLLAI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 180 LGWFVLPESHLAEKQPLHITHLNPFRSLWWVFGIKAIlpLLLVYSVISCVAQVPATIWVIygedRYAWGTRMVGLTFAVF 259
Cdd:cd17333 166 LILLTLFPELPSARNPQQSVGAFSASASRLLRNPSII--LGALALFLYVGAETAFSSWVP----SYLVEKKHVSDGLAGY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 260 GV----MYGLSQAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALA-TQGWMVFPVMILLAAGGIAMPALQALLSKQVdE 334
Cdd:cd17333 240 LLsgfwVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLApTLVVGLVATALLGLFMAALFPTILSLGISNL-P 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1133582698 335 GKQGELQGTLVSVMSLASIVGPVVVTTVY-AQTSGLWPGFVWICGAVVYLLCF 386
Cdd:cd17333 319 YAKGKGTSVLLAAGSIGGAIIPFIMGFIAeAVGIQTAMLLITILYAIIFVLAL 371
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
49-384 |
1.15e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 56.42 E-value: 1.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 49 FGYFLAAYALMQFLfspiLGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGIT-GANMAVATAYLADI 127
Cdd:cd17319 44 ASAFFLGYALFQVP----GGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAeAGFFPGAIKALAEW 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 128 SDESERAQRYGYMNACFGIG-FVAGPLLGGVVGAISPRYPFLAAAVFNGLNFLLGWFVLPEshlaekqpLHITHLNPFRS 206
Cdd:cd17319 120 FPARERGRATGLFNSGAPLGaAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ--------VWGLALGYFGI 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 207 LWWVFGIKAILPLLLVYSVISCVAQVPATIWVIYGedryawgtrmvgltFAVFGVMYGlsqafltGWMSKRWGDRRSLLL 286
Cdd:cd17319 192 NYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFL--------------AGAIGMILG-------GRLSDRLLRGARRLV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 287 ALIADNLGFVGMALATQGWMVFPVMILLAAGGIAMPALQALLSKQVDEGKQGELQGTLVSVM----SLASIVGPVVVTTV 362
Cdd:cd17319 251 IIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLInsggNLGGFVAPLLIGYL 330
|
330 340
....*....|....*....|....*..
gi 1133582698 363 YAQTSGLWPGFVW-----ICGAVVYLL 384
Cdd:cd17319 331 VDATGSYTAAFLFlaavaLLAALLVLL 357
|
|
| MFS_SLC46A3 |
cd17448 |
Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
66-391 |
1.55e-08 |
|
Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 3 (SLC46A3) is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. SLC46A3 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341006 Cd Length: 396 Bit Score: 56.28 E-value: 1.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 66 ILGALSDRYGRRPVLLVSLAGAAVD----YTVMAFTTSLPILYLGRIVAGITGaNMAV----ATAYLADIS-DESERAQR 136
Cdd:cd17448 88 ILVSYSDRHGRKFSIILPSIGALLTslsyCLVSYFSFPLNLLIASSFISGLFG-GFTTfiggCFAYVADLCkDHKQKTIR 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 137 YGYMNACFGI-GFVAGPLLGGVVGAISPRYPFLAAAVFNGLNFLLGWFVLpeshlaekqplhithlnpfrslwWVfgika 215
Cdd:cd17448 167 MAVVDMILGVlTGLAGLSSGYFIRALGFNWPFLTIALLHVVNLLYILFFL-----------------------VV----- 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 216 ILPLLLVYSVISCVAQVPATIWVIYGEDR-YAWGTRMVGLTFAVFGVMYGLSqaFLTGWM-SKRWGDRRSLLLALIADNL 293
Cdd:cd17448 219 LCLLLFAFSTYLLANFGGASIFILYELNApLCWNEVLVGYGSAASTAIFLTS--FVGVALfSRCLPDIYIVFIGIFSVAG 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 294 GFVGMALATQGWMVFPVMILLAAGGIAMPALQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYAQTSGLWPGF 373
Cdd:cd17448 297 GMIMTAFAKTTLLMFLVRLPLLFAIMPFPVLRSMMSKVVLPSEQGALFACVAFLETLSGVLSVTIFNSIYAATVAWFPGF 376
|
330
....*....|....*...
gi 1133582698 374 VWICGAVVYLLCFPALGF 391
Cdd:cd17448 377 SFLLSAGLCLIPASLLCV 394
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
54-389 |
1.68e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 56.13 E-value: 1.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 54 AAYALMQFLF---SPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGITGANM--AVATAYLADIS 128
Cdd:cd17355 42 LAFTVGLLAFglaQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTlaAVAFATVAAWW 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 129 DESERAQRYGYMNACFGIG-FVAGPLLGGVVGAISPRYPFLAAAVFNGLNFLLGWFVL--PESHLAEKQPLHITHLNPFR 205
Cdd:cd17355 122 FERRRGLALGILTAGGGLGsLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLrrRPADLALRAYDDASPASPGS 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 206 SLWWVFGIKAIlpLLLVYSVISCVAQVPATI--WVIYGEDRYAwGTRMVGLTFAVFGVMYGLSQAFLtGWMSKRWGDRRS 283
Cdd:cd17355 202 TLKEALRSASF--WLLALAFFLCGFAVVGLIvhLVPYLADRGI-SPAAAAVALALIGLFNIVGRLLS-GWLGDRYSPRRL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 284 LLLALIADNLGFVGMALAT---QGWMVFPVMILLAAGGIaMPALQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVT 360
Cdd:cd17355 278 LAASYALRALGLALLLLLPfppLALLLFAALFGLGWGAT-VPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGG 356
|
330 340
....*....|....*....|....*....
gi 1133582698 361 TVYAQTSGLWPGFvWICGAVVYLLCFPAL 389
Cdd:cd17355 357 LLYDRTGSYTAAW-ALAVALGLIAALLVL 384
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
49-366 |
2.11e-08 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 55.69 E-value: 2.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 49 FGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTS-----LPILYLGRIVAGITGANMaVATAY 123
Cdd:cd17482 41 WGYANSIASLVIALLAPILGAIADYSGRKKRFLAFFCLIGVVSTALLFFVTpgqwlLALLLFILANIGFSGANV-FYDAF 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 124 LADISDE------SERAQRYGYMNACF----GIGFVAGPLLGGVVGAISPRYPFLAAAvfnglnfllgwfvlpeshlaek 193
Cdd:cd17482 120 LPDVASPermdrvSSLGYALGYIGGGLlfavNLVLILGPDAFGLDTAEAVRLSFLSVA---------------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 194 qplhithlnpfrsLWW-VFGI--KAILPLLLVYSVISCVAQVPATIWVIYGEDRYAWGTRMVGLTFAVFGVMYGLSqAFL 270
Cdd:cd17482 178 -------------LWWaLFSIplKQLLLFLIAYFFYIDGVQTIIRMATIYGAEEGKLGSSALILALLLTQFVAFPG-ALL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 271 TGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFpvmILLAAGGIAMPALQAL----LSKQVDEGKQGELQGTLVS 346
Cdd:cd17482 244 FGWLAERFGAKRAILVSLVIYILICIYAYFMLTAWDFW---ILAALIGLVQGGIQALsrslFGRLIPKGKSAEFFGFYNI 320
|
330 340
....*....|....*....|
gi 1133582698 347 VMSLASIVGPVVVTTVYAQT 366
Cdd:cd17482 321 SGKFAAIIGPLLFGLITQLT 340
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
68-189 |
2.29e-08 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 55.27 E-value: 2.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 68 GALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERAqRYGYMNACFG- 145
Cdd:cd17315 55 GPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLgVGLASVLVPLYISEIAPAKIRG-ALGTLNQLMIt 133
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1133582698 146 IGFVAGPLLGGVVGAISP---RYPFLAAAVFnGLNFLLGWFVLPESH 189
Cdd:cd17315 134 FGILLAYLLGLALSLSPPgwwRLMFALAAVP-ALLQLLLMFFLPESR 179
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
5-358 |
2.55e-08 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 55.47 E-value: 2.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 5 KSVGRPLLVILATVTLDSVGLGLVLPVLPSLIRELTHTtdvAGHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSL 84
Cdd:TIGR00710 1 KSAKAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTP---ASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 85 AGAAVDYTVMAFTTSLPILYLGRIVAGITGANMAVAT-AYLADISDESERAQRYGYMNACFGIGFVAGPLLGG-VVGAIS 162
Cdd:TIGR00710 78 FIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISqALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGyILVWLS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 163 PRYPFLAAAVFNGLNFLLGWFVLPESHLAEKQPLHITHLNPFRSLWwvfGIKAILPLLLVYSVISCVAQVPATIWVIYGE 242
Cdd:TIGR00710 158 WHAIFAFLSLAGILLSALIFFILPETLPYEARIQISTYFETFLLLL---KSKMFWGYALIYGASFGGFFAFFSGAPFVYI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 243 DRYAWGTRMVGLTFAVFGVMYgLSQAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILLAAG--GIA 320
Cdd:TIGR00710 235 DIMGVSPSVFGLLFALNIIAM-IFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMfvGIG 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1133582698 321 MPALQALLSKQVDE------GKQGELQGTLVSVmsLASIVGPVV 358
Cdd:TIGR00710 314 NSMISSIAMAYALEdfphvaGTASALFGTLRLV--LGAIVGYLV 355
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
50-187 |
2.56e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 55.26 E-value: 2.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 50 GYFLAAYALMQFLFSPILGALSDRYGRR--PVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLAD 126
Cdd:COG2271 219 GLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFgLGGAFGLLWALAAE 298
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1133582698 127 ISDESERAQRYGYMNAC-FGIGFVAGPLLGGVVGAISPRYPFLAAAVFNGLNFLLGWFVLPE 187
Cdd:COG2271 299 LFPKKARGTASGLVNTFgFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
56-356 |
2.61e-08 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 55.30 E-value: 2.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 56 YALMQFLFSPILGALSDRYGRRPVLLVSL---AGAAVDYTVMAFTTSLPIL----YLGRIVAGITGAnmAVATAYLADIS 128
Cdd:cd17385 43 FALVIFLTSPIFGKYLVKIGAKFMFVAGMfvsGGCTILFGFLDRVPDGTVFialcFLVRIVEAVGFA--AFITASFAIIA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 129 DE--SERAQRYGYMNACFGIGFVAGPLLGGVV-GAISPRYPFLAAAVFNGLNFLLGWFVLPESHLAEKQPLhithlnpfR 205
Cdd:cd17385 121 KEfpNNIATVLGTLETFSGLGLMLGPPLGGFLyQAGGYELPFLVLGCLLLLTVPLNMFILPRYDDDPSPKS--------G 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 206 SLWWVFGI-KAILPLLLVYSVISCVAQVPAT--IWVIYGEDRYAwgtrMVGLTFAVFGVMYGLSqAFLTGWMSKRWGDRR 282
Cdd:cd17385 193 SMLKLLKIpSVLLLCLSIVSGSVSLGFLDPTlsPHLRQFKLSPG----QVGLMFLILAGSYAIS-APLWGWLSDKKKIPK 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 283 SLL-LALIADNLGFVGMA------LATQGWMVFPVMIL--LAAGGIAMPALQALLSKQVDEG------KQGELQGTLVSV 347
Cdd:cd17385 268 WLMvIGSIITGVGFLLLGpapllpIKSELWMVIIGLVLlgLSLGAALVPTFPELLNCAREYGfpdnlsTYGLVSGLFNAA 347
|
....*....
gi 1133582698 348 MSLASIVGP 356
Cdd:cd17385 348 FSLGAFIGP 356
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
3-188 |
2.79e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 55.44 E-value: 2.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 3 PRKSVGRPLLVILATVTLDSVGLGLVLPVLPSLIRELTHTTDVAGhfgyFLAAYALMQFLFSPIL-GALSDRYGRRPVLL 81
Cdd:TIGR00895 11 LSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLG----FLFSAGLIGMAFGALFfGPLADRIGRRRVLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 82 VSLAGAAVDYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGV-VG 159
Cdd:TIGR00895 87 WSILLFSVFTLLCALATNVTQLLILRFLAGLgLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWlIP 166
|
170 180
....*....|....*....|....*....
gi 1133582698 160 AISPRYPFLAAAVFNGLNFLLGWFVLPES 188
Cdd:TIGR00895 167 VFGWRSLFYVGGIAPLLLLLLLMRFLPES 195
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
29-389 |
3.30e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 54.94 E-value: 3.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 29 LPVLPSLIRELTHTTdvAGHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRI 108
Cdd:cd17475 15 IPALAPFLQEDLHLS--LAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 109 VAGITGANM------AVATAYladisDESERAQRYGYMNACFGIG-FVAGPLLGGVVGAISPRYPFLAAAVFNGLNFLLG 181
Cdd:cd17475 93 LVGAGYGSVqpgggrAIMRWF-----PPRERGLAMGIRQTGVPLGgALAAALLPPLALHYGWRAAFVVAGLVSILAAVLF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 182 WFVLPESHLAEKQPLHITHLnpFRSLWWVFGIKAILPLLLVYSVISCVAQVPATIWVIYGEDRYAWGTRMVGLTFAVFGV 261
Cdd:cd17475 168 WLFYREPPAASAATESASTL--LRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 262 MYGLSQAFLtGWMSKRWGD---RRSLLLALIADNLGFVGMALATQG---WMVFPVMILLAAGGIAMPALQ-ALLSKQVDE 334
Cdd:cd17475 246 GGALGRIGL-GRVSDRVFGgrrRPVLVITAAIAAAALLVLSLLSPGtplWLLVLLLILLGLFAIGWNGLYlTLVAESAGP 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1133582698 335 GKQGELQGTLVSVMSLASIVGPVVVTTVYAQTSGlwPGFVWICGAVVYLLCFPAL 389
Cdd:cd17475 325 EQAGTALGLANTINFIGIAIGPPLFGLLVDATHS--YAPAWLALALLLVLAALLL 377
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
9-183 |
6.81e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.16 E-value: 6.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 9 RPLLVILATVTLDSVGLGLVLPVLPSLIRELTHTTdvAGHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAA 88
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAKEVLGGG--AAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLG 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 89 VDYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVG-AISPRYP 166
Cdd:cd06173 286 LALLVLGLSPSLWLLLAALFLLGLaGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLAdALGLSAV 365
|
170
....*....|....*..
gi 1133582698 167 FLAAAVFNGLNFLLGWF 183
Cdd:cd06173 366 FLLAGALLLLAALLLLL 382
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
30-187 |
9.29e-08 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 53.73 E-value: 9.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 30 PVLPSLIRELtHTTDVAGHFGyfLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIV 109
Cdd:cd17323 20 PALPQIAEDF-HVSEEVANLG--VSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 110 AGITGAN-MAVATAYLADISDESERaqryGYMNACFGIGFVAGPLLGGVVGA-----ISPRYPFLAAAVFNGLNFLLGWF 183
Cdd:cd17323 97 QGFFGSSpLAIGAGTIADLFTPEER----GKAMGVYSLGPLLGPALGPIIGGfitqsLGWRWIFWFLAIISGFCLILIFL 172
|
....
gi 1133582698 184 VLPE 187
Cdd:cd17323 173 FLPI 176
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
15-186 |
1.62e-07 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 52.79 E-value: 1.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 15 LATVTLDSVGLGL----VLPVLPSLIRELTHTTDVAGHFgyfLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVD 90
Cdd:PRK10091 5 ILSLALGTFGLGMaefgIMGVLTELAHDVGISIPAAGHM---ISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 91 YTVMAFTTSLPILYLGRIVAGIT-GANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVGAI-SPRYPFL 168
Cdd:PRK10091 82 NAMFTLSSSYLMLAIGRLVSGFPhGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEfSWRYTFL 161
|
170
....*....|....*...
gi 1133582698 169 AAAVFNGLNFLLGWFVLP 186
Cdd:PRK10091 162 LIAVFNIAVLASIYFWVP 179
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
55-180 |
1.69e-07 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 53.01 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 55 AYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGITGANMAVATAYLADISDESERA 134
Cdd:cd06179 40 AWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRG 119
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1133582698 135 QRYGYMNACFGIGFVAGPLLGGVV---GAISPRYPFLAAAVFNGLNFLL 180
Cdd:cd06179 120 LVQGVVNLVASPGSALGPLIAGALveaNAAGWRWIFYINAIFNALALIL 168
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
30-386 |
2.08e-07 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 52.69 E-value: 2.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 30 PVLPSLIRELTHTTDVAGhfgYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIV 109
Cdd:cd06180 20 PLLPLMLAELGLSYAQAG---WIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 110 AGITGANMAVATAYLA-DISDESERAQRYGYMNACFGIGFVAGPLL--GGVVGAISPRYPFLAAAVFNGLNFLLGWFVLP 186
Cdd:cd06180 97 AGAASAFVFVFGSNLVlHHATAAGRGHLIGLLFAGVGLGIALSGLLvpAGLGGGLSWRAGWLALALLSAVLLLLSFLLLR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 187 ESHLAEKQPLHITHLNPFRSLWWVfgikailpLLLVYSVISCVAQVPATIWVIYGEDRYAwGTRMVGLTFAVFGVMYGLS 266
Cdd:cd06180 177 RGPSAPTEASAAESAPGLNRPLWR--------LALAYGLFGFGYIITATFLPLIARETGA-GSLLAGLLWSLFGLAAVPS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 267 qAFLTGWMSKRWGDRRSLLLALIADNLGfVGMALATQGWMVFPVMILLAAGG-IAMPALQALLSKQVDEGKQGELQGTLV 345
Cdd:cd06180 248 -CFLWGALSDRWGTRRALAANLLVQAVG-VLLPLLSPGPAGLVLSAVLFGGTfMAITALVMALARELAPPAAPRALALMT 325
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1133582698 346 SVMSLASIVGPVVVTTVYAQTSGLWPGFvwICGAVVYLLCF 386
Cdd:cd06180 326 ASFGVGQILGPLLAGWLADATGGFAPAL--ILAAAALVVAA 364
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
50-188 |
2.44e-07 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 52.66 E-value: 2.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 50 GYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTT---SLPILYLGRIVAGI-TGANMAVATAYLA 125
Cdd:pfam00083 49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIgVGGASVLAPMYIS 128
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1133582698 126 DISDESERaqryGYMNACFGIGFVAGPLLGGVVGAISP--------RYPFLAAAVFNGLNFLLGWFvLPES 188
Cdd:pfam00083 129 EIAPKKLR----GALGSLYQLAITFGILLAYIFGLGLNktsnsdgwRIPLGLQLVPALLLIIGLLF-LPES 194
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
8-327 |
3.00e-07 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 51.95 E-value: 3.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 8 GRPLLVILATVTLDSVGLGLVLPVLPSLIRELtHTTDVAGH--FGYFLAAYALMQflfsPILGALSDRYGRRPVLLVSLA 85
Cdd:PRK10473 2 SRFLLCSFALVLLYPAGIDMYLVGLPRIAADL-NASEAQLHiaFSVYLAGMAAAM----LFAGKIADRSGRKPVAIPGAA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 86 GAAVDYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVvgaISPR 164
Cdd:PRK10473 77 LFIIASLLCSLAETSSLFLAGRFLQGIgAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHL---IMLK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 165 YP----FLAAAVFNGLNFLLGWFVLPESHLAEK-------QPLHITHLNPFrslwwvFGIKAILPLLLVYSVISCVAQVP 233
Cdd:PRK10473 154 FPwqslFYTMAAMGILVLLLSLFILKETRPARApaasskpRENSESLLNRF------FLSRLVITTLSVTVILTFVNTSP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 234 ATIWVIYGEDRYAWGTRMVGLTfavfgvMYGLSQAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMIL 313
Cdd:PRK10473 228 VLLMEQMGFSRGEYAIIMALTA------GVSMTVSFSTPFALGIFKPRTLMLTSQVLFLAAGITLALSPSHAVSLFGITL 301
|
330
....*....|....*....
gi 1133582698 314 LAAG-----GIAMPalQAL 327
Cdd:PRK10473 302 ICAGfsvgfGVAMS--QAL 318
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
29-208 |
3.31e-07 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 51.84 E-value: 3.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 29 LPVLPSLIRELTHTtdvAGHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRI 108
Cdd:PRK11102 11 LPALPVIAADFGVS---AGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 109 VAGITGANMAVAT-AYLADISDESERAQRYGYMNACFGIGFVAGPLLGG-VVGAISPRYPFLAAAVFNGLNFLLGWFVLP 186
Cdd:PRK11102 88 LHGLAAAAASVVInALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGwLLVWFSWHAIFWVLALAAILAAALVFFFIP 167
|
170 180
....*....|....*....|....
gi 1133582698 187 ESHLAEK-QPLHI-THLNPFRSLW 208
Cdd:PRK11102 168 ETLPKERrQPFHLrTTIRNFASLF 191
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
243-391 |
4.93e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.13 E-value: 4.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 243 DRYAWGTRMVGLTFAVFGVMYGLSQaFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILLAAG-GIAM 321
Cdd:COG2814 38 ADLGASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGaGALF 116
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 322 PALQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYAQTSGLWpgfVWICGAVVYLLCFPALGF 391
Cdd:COG2814 117 PAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW---VFLVNAVLALLALLLLLR 183
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
219-389 |
6.16e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.88 E-value: 6.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 219 LLLVYSVISCVAQVPATIWVIYGEDRYAWGTRMVGLTFAVFGVMYGLSQaFLTGWMSKRWGDRRSLLLALIADNLGFVGM 298
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 299 ALATQGWMVFPVMILLAAG-GIAMPALQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYAQTSglWPGFVWIC 377
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG--WRAAFLIL 157
|
170
....*....|..
gi 1133582698 378 GAVVYLLCFPAL 389
Cdd:pfam07690 158 AILSLLAAVLLL 169
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
20-391 |
6.86e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 51.15 E-value: 6.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 20 LDSVGLGLVLPVLPSLIRELTHTTDVAGhfgyFLAAYALMQFLFSPIL-GALSDRYGRRPVLLVSLAGAAVDYTVMAFTT 98
Cdd:cd17371 10 LDGFDLLLLGLVLPALIAEFGLDEAEAG----LLGTVTLAGGAIGGILgGILADRFGRVRVLVITILLFAVFTLLCGFAQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 99 SLPILYLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNACFGIG-----FVAGPLLGGVVGAISPRYPFLAAAv 172
Cdd:cd17371 86 NYWQLLILRALAGLgFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGwllatLLAALLFPLLPPEIAWRVLFLLGA- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 173 fngLNFLLGWFV---LPESHLAEkQPLHITHLNPFRSLWWVFGIKAILPLLLVYSVISCVAQV---PATIWV---IYGED 243
Cdd:cd17371 165 ---LPALLVLFIrrfVKEPPQWQ-AARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGgyyGITTWLpsyLTGER 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 244 RYAWGTRMVGLTFAVFGVMYGLsqaFLTGWMSKRWGDRRSLLLALIadnLGFVGMALATQGWMVFPVM-ILLAAGG---- 318
Cdd:cd17371 241 GLSFEGSAGYLVVTILGGFLGY---LAGGFLADRIGRRNNFALFAL---GSAISILLYFFLPLSPTLIlILGFPLGffas 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1133582698 319 IAMPALQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVyAQTSGLWPGFVwiCGAVVYLLCFPALGF 391
Cdd:cd17371 315 GPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFL-ATSGSLGTAIA--VFAAVYYIAGLVLAL 384
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
66-328 |
9.49e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 50.28 E-value: 9.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 66 ILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNACF 144
Cdd:cd17365 53 LAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLgLGAAMPNAITLVSEYAPARRRSLAVTLMFCGY 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 145 GIGFVAGPLLG-GVVGAISPRYPFLAAAVFNGLNFLLGWFVLpeshlaekqplhithlnpfrSLWWVFgikaILPLLLVY 223
Cdd:cd17365 133 PLGAALGGFLAaALIPAFGWRSVFLLGGVPPLILLPLLRGTL--------------------LLWVTF----FMGLLLVY 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 224 SVISCVAQvpatiwvIYGEDRYAWGTRMVGLTFAVFGVMYGlsqAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQ 303
Cdd:cd17365 189 LLNSWLPK-------LMVEAGYSLSQALTITLLLNIGGVIG---SLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPA 258
|
250 260
....*....|....*....|....*
gi 1133582698 304 GWMVFPVMILLAagGIAMPALQALL 328
Cdd:cd17365 259 SLVLLYVLVFLA--GACVNGAQVGL 281
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
11-207 |
1.11e-06 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 50.26 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 11 LLVILATVTLDSVGLGLVLPVLPSLIRElthttdvAGHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVD 90
Cdd:cd17384 2 LVIVYVALLLDNMLLTVVVPIIPDYLNE-------NVRVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFIS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 91 YTVMAFTTSLPILYLGRIVAGITGANMAVA-TAYLADI-SDESERAQRYGYMNACFGIGFVAGPLLGGV----VGAISpr 164
Cdd:cd17384 75 TLLFAFGESYGVLFLARALQGVGSACSSVAgMGMLASLyPDDKERGKAMGIALGGLALGVLVGPPFGGVmyefVGKSA-- 152
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1133582698 165 yPFLAAAVFNGLNFLLGWFVLPEShlaeKQPLHITHLNPFRSL 207
Cdd:cd17384 153 -PFLILAFLALLDGALQLFILQPS----VKSEESEEGTPWKTL 190
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
11-322 |
2.15e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 49.54 E-value: 2.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 11 LLVILATVTLDSVGLGLVLPVLPSLIRELTHTTDVAGHFGyflAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVD 90
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQ---TVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 91 YTVMAFTTSLPILYLGRIVAGITGANMA-VATAYLADISDESERAQRYGYMNACFGIGFVAGPLLGGVVG--AISPRYPF 167
Cdd:cd17328 78 TLLSSFAPNFWQLLLFRALVGIGEASYSpIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAqaTGGWRWAF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 168 LAAAVFNGLNFLLGWFVL--PESHLAEKQPLHITHLNPF-RSLWWVFGIKAILPLLLVYSVISCV--AQVPATIWVIY-G 241
Cdd:cd17328 158 RVTGVLGVLLAILLLLFVrePPRGAAEGGVMAKSTATSFlADLKALAKNPSFILSTLGFTAVSFVtgALAFWAPTFFLrA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 242 EDRYAWGTRMVGLTFAVFGVMYGLSQAFLTGWMSKRWGDRR-------SLLLALIADNLGFVGMALATQGWMVFPVMILL 314
Cdd:cd17328 238 FGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTpradplvCAVGLLAAAPFLFLALVLALSNLLLAWVLLFL 317
|
....*...
gi 1133582698 315 AAGGIAMP 322
Cdd:cd17328 318 GEFLLSLN 325
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
61-188 |
2.86e-06 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 49.24 E-value: 2.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 61 FLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGITGANMAVATAYL-ADISDESERAQRYGY 139
Cdd:TIGR00898 141 LLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLnTEFLPKKQRAIVGTL 220
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1133582698 140 MNACFGIGFVagpLLGGVVGAISP-RYPFLAAAVFNGLNFLLGWFVlPES 188
Cdd:TIGR00898 221 IQVFFSLGLV---LLPLVAYFIPDwRWLQLAVSLPTFLFFLLSWFV-PES 266
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
46-185 |
3.21e-06 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 49.00 E-value: 3.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 46 AGHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGIT-GANMAVATAYL 124
Cdd:COG2270 273 TTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVmGGIQALSRSLL 352
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1133582698 125 ADISDESERAQRYGYMNACFGIGFVAGPLLGGVVGAI--SPRYPFLAAAVFnglnFLLGWFVL 185
Cdd:COG2270 353 ARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLtgSQRLGILSLIVF----FVIGLVLL 411
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
9-186 |
5.01e-06 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 48.35 E-value: 5.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 9 RPLLVILATVTLDSVGLGLVLPVLPSLIRELTHTTDVaghFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAA 88
Cdd:cd17335 198 PRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKTL---IGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYV 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 89 VDYTVMAFTTSLPILYLGRIVAGIT-GANMAVATAYLADISDESERAQRYGYMNA-CFGIGFVAGPLLGGV-VGAISPRY 165
Cdd:cd17335 275 VRWLLYSFLENPWLVLPIELLHGLTfALVWAAAVSYASAAAPPGLRATAQGLLQGlYFGLGGGLGSLIGGYlYEAFGART 354
|
170 180
....*....|....*....|.
gi 1133582698 166 PFLAAAVFnGLNFLLGWFVLP 186
Cdd:cd17335 355 TFRFFAIA-ALAGLLAFFLIQ 374
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
68-389 |
5.10e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 48.31 E-value: 5.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 68 GALSDRYGRR-PVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVA----GITGAnmaVATAYLADISDESERAQRYGYMNA 142
Cdd:cd17370 55 GYLSDRTGKRkPLVILGYGLSALAKPLLALAGSWQLVLLLRILErlgkGIRTP---PRDALLADATPPSGRGKAFGLHRA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 143 CFGIGFVAGPLLGGVV---GAISPRYPFLAAAVFNGLNFLLGWFVL---PESHLAEKQPLHITHLNPFRSLWWVFGIKAI 216
Cdd:cd17370 132 LDTLGAVLGPLLAALLlylLGGNYRTIFLLAAIPALLALLILLFVVkeyPRPPKLRKKSKKTSLKKLPKAFWLYLLAVAL 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 217 LPL------LLVYSViscvAQVPATIWVIygedryawgtrmvGLTFAVFGVMYGLSqAFLTGWMSKRWGDRRSLLLALIA 290
Cdd:cd17370 212 FALgnfsfaFLILRA----QELGLSAALI-------------PLLYALFNLVYALA-AYPAGRLSDRIGRKKLLILGYLS 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 291 DNLGFVGMALATQGWMVFPVMILLAAG-GIAMPALQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYAQTSgl 369
Cdd:cd17370 274 LALAYLGFALGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS-- 351
|
330 340
....*....|....*....|
gi 1133582698 370 wPGFVWICGAVVYLLCFPAL 389
Cdd:cd17370 352 -PSAAFLFSAVLALIALLLL 370
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
56-379 |
9.01e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 47.60 E-value: 9.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 56 YALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGrivAGITGAnMAVATAYLADISD-----E 130
Cdd:cd17353 47 TIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLG---YGVLGG-IGAGIGYITPVSTavkwfP 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 131 SERAQRYGYMNACFGIG-FVAGPLLGGVVGAISPRYPFLAAAVFNGLNFLLGWFVL----PESHLAEKQPLHITHLNPFR 205
Cdd:cd17353 123 DKRGLATGIVIAGFGLGsLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIrdppKGWVPPGVDPLANNAENSPR 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 206 SLWW--VFGIKAILPLLLVYSVISCVAQVPATIWVIYGEDRYAWGTRMVGLTFAVFGVMYGLSQAFLtGWMSKRWGDRRS 283
Cdd:cd17353 203 DYTPreMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFW-GWLSDKIGRKNT 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 284 LLLALIADNLGFVGMALATQGWMVFPVMILLAAGGIA--MPALQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTT 361
Cdd:cd17353 282 LSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGggFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAY 361
|
330
....*....|....*...
gi 1133582698 362 vYAQTSGLWPGFVWICGA 379
Cdd:cd17353 362 -VLYTGGYNAAFIIAAAL 378
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
14-189 |
1.33e-05 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 47.18 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 14 ILAT--VTLDSVGLGLVL----PVLPSLIRELTHTTDV----AGHFGYFLAAYALMQFLFSpilGALSDRYGRRPVLLVS 83
Cdd:cd17358 1 LLATfvANLGSFSFGIAVgwssPALPSLMSDNSLSLPLtvaqFSWFGSLLTLGALIGALLS---GKLADRIGRKRTLLIS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 84 LAGAAVDYTVMAFTTSLPILYLGRIVAGIT-GANMAVATAYLADISDESERaqryGYMNACFGIGFVAGPLLGGVVGA-I 161
Cdd:cd17358 78 AIPCILGWLLIAFAKDVWMLYLGRFLAGFGgGAASVVVPVYIAEIAPKNVR----GALGSLNQLLVNIGILLGYVLGSfL 153
|
170 180
....*....|....*....|....*...
gi 1133582698 162 SPRYPFLAAAVFNGLnFLLGWFVLPESH 189
Cdd:cd17358 154 PWRTLALIGAIPPVV-FLILLFFIPESP 180
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
52-381 |
1.75e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.50 E-value: 1.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 52 FLAAYALMQFLFspilGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDE 130
Cdd:cd17312 47 FLIAYAVGKFIS----GFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLfQSMGWPPCVKLLGNWFSK 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 131 SERAQRYGYMNACFGIG-FVAGPLLGGVVGAISPRYPFLAAAVFNGLNFLLGWFVLPEShlaekqPLHIthlnpfrslwW 209
Cdd:cd17312 123 KERGTVYGIWSTSHNFGgILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDS------PPYV----------W 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 210 VFGIKAILPLLLVYSVIScvaqvpatiWV-IYGEDRYAWGTRMVGLTFAVFGVMyGLSQAFLTGWMSKRWGDRRSLLLAL 288
Cdd:cd17312 187 VLSLAYAFVYIVRYACLD---------WGpLYLYEVKGYSLIDAGWFSSLYEVG-GIAGTILAGLLSDKLFGGRRAPIAV 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 289 I---ADNLGFVGMALATQGWMVFPVMILLAAGGIAMPALQALLSKQVDEGKQgELQGT---LVSVM-SLASIVGPVVVTT 361
Cdd:cd17312 257 IymlLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRK-EAAGTatgFVGLFgYLGASLAGLPLGY 335
|
330 340
....*....|....*....|
gi 1133582698 362 VYAQTSGLWPGFVWICGAVV 381
Cdd:cd17312 336 IIDHYGWSTVFYFLISAALL 355
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
64-184 |
2.50e-05 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 45.74 E-value: 2.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 64 SPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGITGANMAVATAYLA-DISDESERAQRYGYMNA 142
Cdd:cd17374 52 ALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGtEWTTPRHRALAITLTSC 131
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1133582698 143 CFGIGFVagpLLGGVVGAISP-RYPFLAAAVFNGLNFLLGWFV 184
Cdd:cd17374 132 FFSIGQM---LLAGLAYAIRDwRLLQLVVSVPFFLFFLYSWWL 171
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
52-186 |
5.24e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 44.88 E-value: 5.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 52 FLAAYALMQFLF-----SPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGIT-GANMAVATAYLA 125
Cdd:cd17317 25 WLVALVQTIFFLgvligSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTsAGIFTVGFVLGM 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1133582698 126 DISDESERAQRYGYMNACFGIGFVagpLLGGVVGAISPRYPFLAAAVFNGLNFLLGWFVLP 186
Cdd:cd17317 105 EIVGPKYRSFVGILFGLFWALGYM---LLALLAYLIRDWRWLQLAISLPGLLFLLLLWWLP 162
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
30-385 |
5.71e-05 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 45.05 E-value: 5.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 30 PVLPSLIRELTHTTDVAGhfgyFLAAYALMQFLFSPILGALSDRYGR---RPVLLVSLAGAAVDYTVMAFTTSLPILYLG 106
Cdd:pfam06779 14 PILPVMIAEGQFSLSQAG----LLAAANYAGYLAGALLASFAWRHGAsrlRPALLAGLLATVLLLLAMAATSSFWAVLLI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 107 RIVAGITGANMAVATAYLADISDESERAQRYGYMNAC-FGIGFVAGPLL--GGVVGAISPRYPFLAAAVFNGLNFLLGWF 183
Cdd:pfam06779 90 RFLAGVASAAVMIFGSSLILGHATAARRAFVGALLFAgVGIGIALSGLLvpLGLQLGLGGSSLWYGAGVLSAVLTLAVFP 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 184 VLPESHLAEKQPLHITHLNPFRSLWWVFgikailpLLLVYSVISCVAQVPATIWVIYGEDRYAwgtrmVGLTFAVFGVMY 263
Cdd:pfam06779 170 LLPRRAPRHASAPAPAAKPLQRSLPLWI-------LTLAYGLAGFGYIITATFLPAMARDGFG-----GPAAAALFWSLF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 264 GLSQA---FLTGWMSKRWGDRRSLLLALIADNLG-FVGMALATQGWMVFPVmILLAAGGIAMPALQALLSKQVDEGKQGE 339
Cdd:pfam06779 238 GLAAAlgvLVWLRAAKRWGTRPALTAALLIQALGvLLSLLSPSPAGLAVSS-LLFGGTFMAITSLVMQLARELAPPAPRR 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1133582698 340 LQGTLVSVMSLASIVGPVVVTTVYAQTSGLWPgfVWICGAVVYLLC 385
Cdd:pfam06779 317 LLGLMTASFGIGQILGPLLASLLTAATGGLTP--ALLLAAAALVLA 360
|
|
| MFS_AmpG_like |
cd17486 |
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ... |
25-380 |
5.77e-05 |
|
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 44.90 E-value: 5.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 25 LGLVLPVLPSLIRELTHTTDVAGHFGYFLAAYALmQFLFSPILgalsDRYG------RRPVLLVSLAGAAVDYTVMAFT- 97
Cdd:cd17486 12 YLLTGTTLQAWLKEAGVDLDTIGLFSLVGLPYSL-KFLWAPLV----DRYStpflgrRRGWILLTQILLMAALIALAFLd 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 98 --TSLPILYLGRIVAGITGA-NMAVATAYLADISDESERAQRYGYMNACFGIG-FVAGPLLGGVVGAISPRYPFLAAAVF 173
Cdd:cd17486 87 pfTNLVLSALLFLLVAFFSAtQDIAIDAYRIEALEDKEQGAGAGVRVNGYRIGmLVAGAGALYLADSLSWSAVYLIMAAL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 174 NGLNFLLGWFVLPESHL----AEKQPLHITHLNPFRSLWWVFGIKAILPLLLVYSVISCVAQVPATIWVIygEDRYAWGT 249
Cdd:cd17486 167 MGPGILATLFAPEPPRTdppaNSLSETVVAFFAPFKDFFGQPGALLILAFILLYKLGDAMLGAMATPFLL--DLGFTKTE 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 250 rmVGLTFAVFGVMYGLSQAFLTGWMSKRWGDRRSLLLALIA---DNLGFVGMALATQG-WMVFPVMILLA-AGGIAMPAL 324
Cdd:cd17486 245 --IGAVYKTVGLIATIVGGLLGGFLMSRLGLKRSLWLFGILqalSNLGFIYLAHAGPNlTLLVAAVAVENfGGGLGTTAF 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 325 QALLSKQVDegkqGELQGT----LVSVMSLASIVgpVVVTTVYAQTSGLWPGFVWICGAV 380
Cdd:cd17486 323 VAYLMSLCN----GEFTATqyalLSSLMALGRMV--LGAPSGWLAEALGWTGFFLLTTLA 376
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
244-334 |
5.79e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.95 E-value: 5.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 244 RYAWGTRMVGLTFAVFGVMYGLSQAFlTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWM---VFPVMILLAAGGIA 320
Cdd:cd17355 32 EFGWSRAVISLAFTVGLLAFGLAQPF-VGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQlylLWGLLGGGGAGTLA 110
|
90
....*....|....
gi 1133582698 321 MPALQALLSKQVDE 334
Cdd:cd17355 111 AVAFATVAAWWFER 124
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
64-188 |
1.18e-04 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 43.88 E-value: 1.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 64 SPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNA 142
Cdd:cd17362 56 SLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVgIGLAMHAAPVYIAETSPSHIRGLLVSLKEL 135
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1133582698 143 CFGIGFVAGPLLG-GVVGAISPRYPFLAAAVFNGLNFLLGWFVLPES 188
Cdd:cd17362 136 FIVLGILLGYVSGyAFADVVGGWRYMYGLAAPPALLLGIGMWFLPPS 182
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
52-188 |
1.48e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 43.79 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 52 FLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLP---ILYLGRIVAGI-TGANMAVATAYLADI 127
Cdd:cd17357 54 IVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKspeLLIFGRFLVGIaCGLSTGFVPMYLQEI 133
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1133582698 128 SDESERaqryGYMNACFGIGFVAGPLLGGVVGAISP-------RYPFLAAAVFNGLNFLLgWFVLPES 188
Cdd:cd17357 134 SPSELR----GALGSLTQIGVTLGILLGQVFGLPSVlgtetlwPYLLFFPGIPALLQLAA-LPFFPES 196
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
52-379 |
1.62e-04 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 43.39 E-value: 1.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 52 FLAAYALMQFLfspiLGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGItGANMAVATAYlADISDES 131
Cdd:PRK15402 57 YLAGGMFLQWL----LGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGI-GLCFIGAVGY-AAIQESF 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 132 ERAQRYGYMNACFGIGFVAgPLLGGVVGAI-----SPRYPFLAAAVFNGLNFLLGWFVLPESHLAEKQPLHITHL----- 201
Cdd:PRK15402 131 EEADAIKITALMANVALLA-PLLGPLVGAAlihvlPWRGMFVLFAALAALSFFGLWRAMPETAGRVGEKLSLKELgrdyk 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 202 NPFRSLWWVFGIKAI----LPLLLvysvisCVAQVPATIWVIYGEDRYAWGTrmvgLTFAVFGVMygLSQAFLTGWMSKR 277
Cdd:PRK15402 210 LVLKNRRFVAGALALglvsLPLLA------WIALSPVILISGEQLSSYEYGL----LQVPVFGAL--IAGNLTLARLTSR 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 278 WGDRRSLLLALIADNLGFVGMALAT------QGWMVfPVMILLAAG-GIAMPALQALLSKQVDEGKqgelqGTLVSVMSL 350
Cdd:PRK15402 278 RPLRSLIRMGLWPMVAGLLLAALATvisshaYLWLT-AGLSLYAFGiGLANAGLYRLTLFSSDVSK-----GTVSAAMGM 351
|
330 340 350
....*....|....*....|....*....|...
gi 1133582698 351 ASI----VGPVVVTTVYAQTSGLWpgFVWICGA 379
Cdd:PRK15402 352 LSMliftVGIELSKHAYLGGGNGL--FNLFNLA 382
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
50-182 |
1.87e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.18 E-value: 1.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 50 GYFLAAYALMQFLFSPILGALSDRY-GRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGITGAN-MAVATAYLADI 127
Cdd:cd06174 242 GLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGlLPLSFALIAEL 321
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1133582698 128 SDESERAQRYGYMNACFGIGFVAGPLLGGV--VGAISPRYPFLAAAVFNGLNFLLGW 182
Cdd:cd06174 322 FPPEIRGTAFGLLNTFGFLGGAIGPLLAGFllAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_SLC46A2_TSCOT |
cd17450 |
Solute carrier family 46 member 2, also called Thymic stromal cotransporter protein, of the ... |
58-384 |
1.95e-04 |
|
Solute carrier family 46 member 2, also called Thymic stromal cotransporter protein, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 2 (SLC46A2) is also called thymic stromal cotransporter protein (TSCOT). It is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. Polymorphisms in TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis. TSCOT belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341008 Cd Length: 383 Bit Score: 43.20 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 58 LMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYT----VMAFTTSLPILYLGRIVAGITG---ANMAVATAYLADISDE 130
Cdd:cd17450 62 LSPLLPAYLLAKLGDRRHRKITICVPLLGYLLSRAllllVILLDWPLEVMYGAAALNGLTGgftAYWAGVMALASLASSE 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 131 SERAQRYGYMNACFGigfvagplLGGVVGAISPRYPFLAAAVFNGlnfllGWFVLPESHLAekqplhithLNPFRSLWWV 210
Cdd:cd17450 142 GRRSVRLITIELVYG--------LAGFLGSLASGHIFVHYTINHH-----QGAILAACSLV---------LYVLCLLYSV 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 211 FGIKAILPLLLVYSVISCVAQVPA--TIWVIYGEDRYAWGTRMVGLTFAVFGVMYGLSqaFLTGWM-SKRWGDRRSLLLA 287
Cdd:cd17450 200 FVLKITIALLFVGAILYDLAVAGGmdVLSVFVLKEPLSWGAVEVGYGNAAGYMIFITS--FLGVFVfSRCLRDTTMIMIG 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 288 LIADNLGFVGMALATQGWMVFPVMILLAAGGIAMPALQALLSKQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYAQTS 367
Cdd:cd17450 278 MVSFSSGILIMAFVKWTFMFYIARAVMLFALIPLPTIRSLISKQVQGSSYGKVFVMLQLSLKLTGVATSTIYNKIYQATL 357
|
330
....*....|....*..
gi 1133582698 368 GLWPGFVWICGAVVYLL 384
Cdd:cd17450 358 DWFPGFCFILSSILGFL 374
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
52-193 |
2.13e-04 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 42.97 E-value: 2.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 52 FLAAYALMQFLFSPilgaLSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDE 130
Cdd:PRK11652 52 YLLTYGLSQLFYGP----LSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLgTGVGGVMARTLPRDLYEG 127
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1133582698 131 SERAQRYGYMNACFGIGFVAGPLLGGVVGAI-SPRYPFLAAAVFNGLNFLLGWFVLPESHLAEK 193
Cdd:PRK11652 128 TQLRHANSLLNMGILVSPLLAPLIGGLLTTLfGWRACYLFLLLLGAGVTFSMARWMPETRPADA 191
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
62-335 |
2.24e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 42.98 E-value: 2.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 62 LFSPILGALSDRY-----GRRPVLLVSLAGAAVdYTVMAFTTSLPILYLGRIVAGITGANMAVA--------TAYLADIS 128
Cdd:cd17332 50 INDPLMGYLIDRTrsrwgRFRPWLLWGAIPLAL-LFVLLFTTPDGSGTGKLIYALITYILLDLLytlvnipyTALIPELT 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 129 DES-ERAQRYGY-----MNACFGIGFVAGPLLGGVVGAISPRYPFLAAAVFNGLN---FLLGWFVLPESHLAEKQPlhIT 199
Cdd:cd17332 129 DDPeERTSLTSWrmffaTIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGiilLLICFFGTRERVVPPEEE--KS 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 200 HLNPFRSLWWVFGIKAILPLLLVYSVISCVAQVPATIWVIYGEdrYAWGTRMVglTFAVFGVMYGLSQAFLTGWM--SKR 277
Cdd:cd17332 207 KLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFK--YVLGGRAE--LVLLLLLILSGALLALLPWPplKKR 282
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1133582698 278 WGDRRSLLLALIADNLGFVGMALATQG--WMVFPVMILLAAG-GIAMPALQALLSKQVDEG 335
Cdd:cd17332 283 FGKKKAFFIGLLLAILGLLLLFFLPPGnlVLILVLAVLAGIGyGGANLLPWAMLADVIDYG 343
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
3-173 |
2.28e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.93 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 3 PRKSVGRPLLVILATVTLDS---VGLGLVLPVLpslireLTHTtdvagHFGYFLAAYALMQFLF-----SPILGALSDRY 74
Cdd:cd17478 189 TLKGVWRALLLLLIIVFLRSwvlSSLTTFLPFY------LVQR-----GYSLVFAGLLLSLFLFagaigTLIGGPLSDRF 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 75 GRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGITGANMAVATAYLADISDESERAQRYGYMNACFGIGFVAGPLL 154
Cdd:cd17478 258 GRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMGLSFGLGGIGAPVL 337
|
170
....*....|....*....
gi 1133582698 155 GGVVGAISPRYPFLAAAVF 173
Cdd:cd17478 338 GALADAFGLESVLLILALL 356
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
11-171 |
2.76e-04 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 42.68 E-value: 2.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 11 LLVILATVTLDSVGLGLVLPVLPSLIRElthttDVAghFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVD 90
Cdd:cd17383 1 LVIVCIALLLDNMLYMVIVPIIPDYLNE-----DIA--IGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 91 YTVMAFTTSLPILYLGRivaGITGANMAVA-TAYLADISD----ESERAQRYGYMNACFGIGFVAGPLLGGVVGAIS-PR 164
Cdd:cd17383 74 TAVFAFGESYAVLFFAR---SLQGVGSAFAdTAGLAMIADrfteEAERSKALGIALAFISFGCLVAPPFGGILYEFAgKE 150
|
....*..
gi 1133582698 165 YPFLAAA 171
Cdd:cd17383 151 VPFLILA 157
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
43-355 |
3.39e-04 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 42.68 E-value: 3.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 43 TDVAG----HFGYFLAAYALMQFLFSPILGALSD----RYGR-RPVLLVSLAGAAVDYTVMAFTtslPILYLGRIVAGIT 113
Cdd:pfam13347 25 TDVLGlsaaAVGLVLLVARLVDAFTDPIVGHIIDrtrtRWGRrRPWLLLSAIILAVSFILLFTP---PELGRAPLFIWLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 114 GANMAVATAY-------------LADISDESERAQRYGYMNACFGI---GFVAGPLLGGVVGAISPRYPFLAAAVFNGLN 177
Cdd:pfam13347 102 ATYILLRIAYtffeipywslgpeLTRDYDERTSLTSYRSFFSVGGGllaAALAFPLVLILGGTGLERKGYRIFALIGAVL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 178 FLLGWFVL------PESHLAEKQPLHITHLNPFRSLWWVFGIKAILPLLLVYSVISCVAQVPATIWVIYGedRYAWGTRM 251
Cdd:pfam13347 182 MLLGVIITaagtkeRVSMRSKEDTGQKEAGSLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYF--RYVLGNGF 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 252 VGLTFAVFGVMYGLSQAFLTGWMSKRWGDRRSLLLALIADNLGFVGM-ALATQGWMVFPVMILLA--AGGIAMPALQALL 328
Cdd:pfam13347 260 AASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALAlLLGPNNTLLFLVLYIIIgfGYGSSFFLPWSML 339
|
330 340 350
....*....|....*....|....*....|
gi 1133582698 329 SKQVDEG--KQGE-LQGTLVSVMSLASIVG 355
Cdd:pfam13347 340 ADVVDYGelRTGKrREGTFFAMWSFISKLA 369
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
68-188 |
4.41e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 42.17 E-value: 4.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 68 GALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERaqryGYMNACFGI 146
Cdd:cd17359 57 GRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLaVGGASALVPMYIAEVAPAEIR----GRLVSLNQL 132
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1133582698 147 GFVAGPLLGGVVGAISPRYP------------FLAAAVFNGLNFLLGWFVLPES 188
Cdd:cd17359 133 MIVFGQLLAYIVNYLIANAGgadwlgaegwrwMLGLEAIPAILFLLGMLFIPES 186
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
23-318 |
5.66e-04 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 41.89 E-value: 5.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 23 VGLGLVLPVLPSLIRELTHTTdvaGHFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAF-----T 97
Cdd:PRK10489 31 FGLGLLGVAVPVQIQMMTGST---LQVGLSVTLTGGAMFIGLMVGGVLADRYDRKKLILLARGTCGLGFIGLALnaflpE 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 98 TSLPILYLGRIVAGITGAnmAVATAYLADISDESER---AQRYGYMNACFGIGFVAGPLLGGVV---GAISPRYPFLAAA 171
Cdd:PRK10489 108 PSLLAIYLLGLWDGFFGS--LGVTALLAATPALVGRenlMQAGAITMLTVRLGSVISPALGGLLiaaGGVAWNYGLAAAG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 172 VFNGLNFLLGwfvLPESHLAEKQPLHithlnPFRSLW----WVFGIKAILPLLLVYSVIScVAQVPATIWVIYGEDRYAW 247
Cdd:PRK10489 186 TFITLLPLLR---LPALPPPPQPREH-----PLRSLLagfrFLLASPVVGGIALLGGLLT-MASAVRVLYPALADEVWQM 256
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1133582698 248 GTRMVGLTFAV--FGVMYGlsqAFLTGWMSkrwGDRRSLLLALIADNLGFVGMALATQGWMVFPVMILLAAGG 318
Cdd:PRK10489 257 GAAQIGLLYAAvpLGAALG---ALTSGWLA---HSARPGLLMLLSTLGSFLAVGLFGLMPMWILAVLCLALFG 323
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
31-370 |
6.00e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 41.59 E-value: 6.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 31 VLPSLIRELTHTTDVAGH-FGYFLAAYALMQFLFspilGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIV 109
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLlLSSFSIAYGISKFVM----GSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWAL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 110 AGI-TGANMAVATAYLADISDESERAQRYGYMNAC--FGIGFVAGPLLGGVVGAISPRYPFLAAAVFNGLNFLLGWFVLP 186
Cdd:TIGR00881 93 NGIfQGMGWPPCGRTVTKWFSRSERGTWVSFWNCShnVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 187 ESHLAEKQPLHITHLNPFRSLWWVFGIKAILPL--LLVYSVISCVAQVPATIWVIYGEDRYA---WG----TRMVGLTFA 257
Cdd:TIGR00881 173 DSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKqiFLQYVLLNKVLWYISLGYVFVYVVRTGildWSplylTQEKGFSKE 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 258 VFGVMY------GLSQAFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVM--ILLAAGGIAMPALQALLS 329
Cdd:TIGR00881 253 KASWAFtlyelgGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMdlICLFALGFLVYGPQMLIG 332
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1133582698 330 KQVDEGKQGELQGTLVSVMSLASIVGPVVVTTVYAQTSGLW 370
Cdd:TIGR00881 333 VIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGF 373
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
57-125 |
6.76e-04 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 41.47 E-value: 6.76e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1133582698 57 ALMQFLFSPILGALSDRYGRRPVLLVslagaavdYTVMAFTTSLPILYLgrIVAGITGANMAVATAYLA 125
Cdd:PRK15075 284 GVSNFIWLPIGGALSDRIGRRPVLIA--------FTVLAILTAYPALSW--LVAAPSFARMLAVELWLS 342
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
68-188 |
8.48e-04 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 41.23 E-value: 8.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 68 GALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNACFGI 146
Cdd:cd17437 53 GRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIgVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINI 132
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1133582698 147 ----GFVAGPLLGGVVGAISPRYpFLAAAVFNGLNFLLGWFVLPES 188
Cdd:cd17437 133 gillGYVSNYAFSGLPLHVGWRL-MLGVGAVPSLFLAIGVLAMPES 177
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
52-112 |
1.21e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 40.65 E-value: 1.21e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1133582698 52 FLAAYALMQFLFSPilgaLSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGI 112
Cdd:PRK11043 50 FLAGFALGQLLWGP----LSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAV 106
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
21-147 |
1.35e-03 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 40.68 E-value: 1.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 21 DSVGLGLVLPVLPSLIRELTHTTDVAGHFGyFLAAYALMQFLFspILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSL 100
Cdd:cd17438 11 DGVEVFVVGFVLPSAEKDMCLSSSNKGMLG-LIVYLGMMAGAF--IWGGLADKLGRKRCLIISLAINASFAFLSSFVQGY 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1133582698 101 PILYLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNACFGIG 147
Cdd:cd17438 88 GAFLFCRLISGFgIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIG 135
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
50-184 |
1.47e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.61 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 50 GYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGITGANMaVATAY-LADIS 128
Cdd:COG0738 249 ALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLM-FPTIFsLALDG 327
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1133582698 129 DESERAQRYGYMNACFGIGFVAGP-LLGGVVGAISPRYPFLAAAVFNGLNFLLGWFV 184
Cdd:COG0738 328 LGKRTAAAVSAVLIMGIVGGAIGPpLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| PHA03415 |
PHA03415 |
putative internal virion protein; Provisional |
103-180 |
1.61e-03 |
|
putative internal virion protein; Provisional
Pssm-ID: 177643 Cd Length: 1019 Bit Score: 40.78 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 103 LYLGRIVAGITGANMAVATAYLADISDESERAQRY-------GYMNACFGIGFVAGPLLGGVVGAISPRYPflaAAVFNG 175
Cdd:PHA03415 184 LKLGRLGAAAAGASGATAVSAAADVAGKDTEAFDYainagltAGAFALFAGGARLPGLDGGLPGAGAAGAA---GGMFRG 260
|
....*
gi 1133582698 176 LNFLL 180
Cdd:PHA03415 261 LNAFL 265
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
54-128 |
2.25e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 39.95 E-value: 2.25e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1133582698 54 AAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGItGANMAVATA--YLADIS 128
Cdd:cd17360 42 SSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGL-GVGIASMTVplYIAEAA 117
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
53-184 |
3.06e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.56 E-value: 3.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 53 LAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYL--GRIVAGITGANMAVATAYLADISDE 130
Cdd:cd17355 251 LALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLlfAALFGLGWGATVPLTAALAARYFGA 330
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1133582698 131 SERAQRYGYMNACFGIGFVAGPLLGGVVGAISPRY--PFLAAAVFNGLNFLLGWFV 184
Cdd:cd17355 331 RSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYtaAWALAVALGLIAALLVLPI 386
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
66-158 |
3.20e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 39.26 E-value: 3.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 66 ILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERAQRYGYMNACF 144
Cdd:TIGR00895 304 IFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFfVNGGQSGLYALMALFYPTAIRATGVGWAIGIG 383
|
90
....*....|....
gi 1133582698 145 GIGFVAGPLLGGVV 158
Cdd:TIGR00895 384 RLGAIIGPILAGYL 397
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
54-188 |
4.32e-03 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 39.16 E-value: 4.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 54 AAYALMQFLFSPILGALSDRYGRRPVLLVSLA----GAAVdytVMAFTTSLPILYLGRIVAGI-TGANMAVATAYLADIS 128
Cdd:cd17356 52 SIVNLGSFFGALISSFLSDRIGRKKSIQIGCViyiiGAII---QVAAIGKWYQLIVGRIIAGLgVGFASVLVPVYQSEVA 128
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1133582698 129 DESERaqryGYMNACFGIGFVAGPLLGGVV--------GAISPRYPFLAAAVFNGLNFLLGWFvLPES 188
Cdd:cd17356 129 PKHIR----GTLVSLYQLAITIGILVAYCInygthkldGSAQWRIPLGLQIVWGLLLLIGMFF-LPES 191
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
43-121 |
4.41e-03 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 38.87 E-value: 4.41e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1133582698 43 TDVAGhFGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGITGANMAVAT 121
Cdd:cd17396 32 TDVAG-VAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLIIAYVFALLAGAANSFLDTGT 109
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
61-186 |
4.51e-03 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 39.01 E-value: 4.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 61 FLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGITGANMAVATA-YLADISDESERaqryGY 139
Cdd:cd17435 50 LLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCvYIAEIAPQHRR----GL 125
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1133582698 140 MNACFGIGFVAGPLLGGVVGaisprypFLAAAVFNGLNFLLGWFVLP 186
Cdd:cd17435 126 LVSLNELMIVIGILLAYISN-------YAFANVSNGWKYMFGLVIPL 165
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
68-250 |
6.19e-03 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 38.39 E-value: 6.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 68 GALSDRYGRRPVLLVS----LAGAAVDytvmAFTTSLPILYLGRIVAGI-TGANMAVATAYLADISDESERaqryGYMNA 142
Cdd:cd17361 72 SYVTRKWGRKPSMLIGgvlfLVGAALN----AAAQNIAMLIVGRILLGFgVGFGNQAVPLYLSEMAPAKLR----GALNI 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 143 CF----GIGFVAGPLLGGVVGAISP---RYPfLAAAVFNGLNFLLGWFVLPESHLAekQPLHITHLNPFrsLWWVFGIKA 215
Cdd:cd17361 144 GFqlaiTIGILIANLINYGTSKIKPngwRLS-LGLAAVPALILLLGSLFLPETPNS--PQLVIAILIPF--FQQLTGINV 218
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1133582698 216 IL---PLLLV-------YSVISCV----AQVPATIWVIYGEDRyaWGTR 250
Cdd:cd17361 219 IMfyaPVLFQtlgfgsdASLISAVitgaVNVVSTLVSIYLVDR--FGRR 265
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
66-113 |
7.91e-03 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 38.17 E-value: 7.91e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1133582698 66 ILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGIT 113
Cdd:cd17446 52 VFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMA 99
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
61-114 |
8.51e-03 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 38.10 E-value: 8.51e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1133582698 61 FLFSPILGALSDRYGRRPVLLVSLAGAAVDYTVMAFTTSLPILYLGRIVAGITG 114
Cdd:cd17379 47 LIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFG 100
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
243-355 |
9.00e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 37.92 E-value: 9.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 243 DRYAWGTRMVGLTFAVFGVMYGLSQaFLTGWMSKRWGDRRSLLLALIADNLGFVGMALATQGWMVFPVM--ILLAAG-GI 319
Cdd:cd17380 27 KEFGWSKTDQGLVLSSFFWGYALTQ-VLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILsrILLGLGeGV 105
|
90 100 110
....*....|....*....|....*....|....*.
gi 1133582698 320 AMPALQALLSKQVDEGKQGELQGTLVSVMSLASIVG 355
Cdd:cd17380 106 HFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLG 141
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
32-116 |
9.13e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 38.11 E-value: 9.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 32 LPSLIRELTHTTDVaghfGYFLAAYALMQFLFSPILGALSDRYGRRPVLLVS----LAGAAVDYTVMAFTTSLPILYLGR 107
Cdd:pfam06609 67 LPNILQDIGQSENQ----GLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIAThiigLVGAIVGCTANKFNTLLAAMTLLG 142
|
....*....
gi 1133582698 108 IVAGITGAN 116
Cdd:pfam06609 143 VAAGPAGAS 151
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
9-145 |
9.34e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 38.04 E-value: 9.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133582698 9 RPLLVILATVTLDSVGLGLVLPVLPSLIRELTHTTDVAGHFGYFLAAYALMqfLFSPILGALSDRYGRRPVLLVSLAGAA 88
Cdd:cd17367 223 RELLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFM--LLQPLGGRLSDRIGRRPLLLFFGIGGT 300
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1133582698 89 VdYTVMAF-----TTSLPILYLGRIVAG-ITGANMAVATAYLADISDESERAQ----RYGYMNACFG 145
Cdd:cd17367 301 L-ATVPLLsaldhTDSPYTAFALVLVGLvFLSGYTSINAVVKAELFPTHVRALgvglPYALAVAIFG 366
|
|
| |
