NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1139416989|gb|APZ75704|]
View 

NADH dehydrogenase subunit 4L [Castor canadensis]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.50e-38

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 122.35  E-value: 6.50e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139416989  1 MSPILINLFLAFLASLLGALIYRSHLMSSLLCLEGMMLSIFITTTLIALNYNITLSFMFPIIILVFAACEAAVGLALLVT 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1139416989 81 MSNAYGTDYVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.50e-38

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 122.35  E-value: 6.50e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139416989  1 MSPILINLFLAFLASLLGALIYRSHLMSSLLCLEGMMLSIFITTTLIALNYNITLSFMFPIIILVFAACEAAVGLALLVT 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1139416989 81 MSNAYGTDYVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
20-98 7.00e-14

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 61.43  E-value: 7.00e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1139416989 20 LIYRSHLMSSLLCLEGMMLSIFITTTLIALNYNITLSFMFPIIILVFAACEAAVGLALLVTMSNAYGTDYVQNLNLLQC 98
Cdd:pfam00420 17 LLLRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRTHGTDDVDSLNLLKG 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 20-96 3.15e-04

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 36.58  E-value: 3.15e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1139416989 20 LIYRSHLMSSLLCLEGMMLSIFITTTLIALNYNITLSFMFPIIILVFAACEAAVGLALLVTMSNAYGTDYVQNLNLL 96
Cdd:COG0713   21 VLTRRNLIVVLMSIELMLNAVNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAIIVALYRNRGTIDVDDLNEL 97
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.50e-38

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 122.35  E-value: 6.50e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139416989  1 MSPILINLFLAFLASLLGALIYRSHLMSSLLCLEGMMLSIFITTTLIALNYNITLSFMFPIIILVFAACEAAVGLALLVT 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1139416989 81 MSNAYGTDYVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.04e-25

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 90.41  E-value: 3.04e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139416989  1 MSPILINLFLAFLASLLGALIYRSHLMSSLLCLEGMMLSIFITTTLIALNYNITLSFMFPIIILVFAACEAAVGLALLVT 80
Cdd:MTH00126   1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                         90
                 ....*....|....*...
gi 1139416989 81 MSNAYGTDYVQNLNLLQC 98
Cdd:MTH00126  81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 7.38e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 84.13  E-value: 7.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139416989  1 MSPILINLFLAFLASLLGALIYRSHLMSSLLCLEGMMLSIFITTTLIALNYNITLSFMFPIIILVFAACEAAVGLALLVT 80
Cdd:MTH00125   1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                         90
                 ....*....|....*...
gi 1139416989 81 MSNAYGTDYVQNLNLLQC 98
Cdd:MTH00125  81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.71e-22

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 83.50  E-value: 1.71e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139416989  1 MSPILINLFLAFLASLLGALIYRSHLMSSLLCLEGMMLSIFITTTLIALNYNITLSFMFPIIILVFAACEAAVGLALLVT 80
Cdd:MTH00067   1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                         90
                 ....*....|....*...
gi 1139416989 81 MSNAYGTDYVQNLNLLQC 98
Cdd:MTH00067  81 TTRTHGTDHLKNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
20-98 7.00e-14

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 61.43  E-value: 7.00e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1139416989 20 LIYRSHLMSSLLCLEGMMLSIFITTTLIALNYNITLSFMFPIIILVFAACEAAVGLALLVTMSNAYGTDYVQNLNLLQC 98
Cdd:pfam00420 17 LLLRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRTHGTDDVDSLNLLKG 95
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 21-96 3.00e-11

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 54.56  E-value: 3.00e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1139416989 21 IYRSHLMSSLLCLEGMMLSIFITTTLIALNYNITLSFMFPIIILVFAACEAAVGLALLVTMSNAYGTDYVQNLNLL 96
Cdd:MTH00181  18 LYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRTHGSDHLLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 4.49e-11

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 54.15  E-value: 4.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139416989  1 MSPILINLFLAFLASLLGALIYRSHLMSSLLCLEGMMLSIFITTTLIALNYNITLSFMFPIIILVFAACEAAVGLALLVT 80
Cdd:MTH00043   1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                         90
                 ....*....|....*..
gi 1139416989 81 MSNAYGTDYVQNLNLLQ 97
Cdd:MTH00043  81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 20-98 1.05e-10

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 53.31  E-value: 1.05e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1139416989 20 LIYRSHLMSSLLCLEGMMLSIFITttLIALNYNITLSFMFPIIILVFAACEAAVGLALLVTMSNAYGTDYVQNLNLLQC 98
Cdd:MTH00149  21 LFQYKHLLSILLSLEALMLSLLVM--MFSSSGLISFSSYLFLIILTFGACEASLGLSLLVSLIRLHGNDYVSSLSSLKF 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 18-98 4.97e-09

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 48.82  E-value: 4.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139416989 18 GALIYRSHLMSSLLCLEGMMLSIFITTTLIALNYNitLSFMFPIIILVFAACEAAVGLALLVTMSNAYGTDYVQNLNLLQ 97
Cdd:MTH00188  19 TFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYME--KELYLSLVLLTFAACEASVGLALLVSLIRSHGSDYVSSLNLIK 96


                 .
gi 1139416989 98 C 98
Cdd:MTH00188  97 C 97
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 20-98 1.73e-07

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 45.13  E-value: 1.73e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1139416989 20 LIYRSHLMSSLLCLEGMMLSIFITTTLIALNYNITLSFMFpIIILVFAACEAAVGLALLVTMSNAYGTDYVQNLNLLQC 98
Cdd:MTH00013  20 SLQRKHLLMSLLSLEAMILSLALFIPLSLMFANQVNGMLA-IVLLTFGACEASLGLSLLVLMTRSYGNDMLKSLTSNKC 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 20-92 1.78e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 39.37  E-value: 1.78e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1139416989 20 LIYRSHLMSSLLCLEGMMLSIFITTTLIALNYNitLSFMFPIIILVFAACEAAVGLALLVTMSNAYGTDYVQN 92
Cdd:MTH00162  19 LSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFN--YELYFLLFFLTFSVCEGALGLSILVSMIRSHGNDYFSS 89
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 20-96 3.15e-04

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 36.58  E-value: 3.15e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1139416989 20 LIYRSHLMSSLLCLEGMMLSIFITTTLIALNYNITLSFMFPIIILVFAACEAAVGLALLVTMSNAYGTDYVQNLNLL 96
Cdd:COG0713   21 VLTRRNLIVVLMSIELMLNAVNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAIIVALYRNRGTIDVDDLNEL 97
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 18-97 5.91e-04

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 35.78  E-value: 5.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139416989 18 GALIYRSHLMSSLLCLEGMMLSIFITTTLIALNYNITLSFMFPIIILVFAACEAAVGLALLVTMSNAYGTDYVQNLNLLQ 97
Cdd:MTH00180  19 GIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDNLIGQIFTIMILTVAAAESAIGLAILVAYYRIRGTIAVKSLNLLR 98
PRK05715 PRK05715
NADH-quinone oxidoreductase subunit NuoK;
30-96 2.09e-03

NADH-quinone oxidoreductase subunit NuoK;


Pssm-ID: 180218  Cd Length: 100  Bit Score: 34.38  E-value: 2.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1139416989  30 LLCLEGMMLSIFITTTLIALNYNITLSFMFPIIILVFAACEAAVGLALLVTMSNAYGTDYVQNLNLL 96
Cdd:PRK05715   32 LMSIELMLNAVNLNFVAFSSYLGDLDGQVFAFFVITVAAAEAAIGLAILLQLYRNRGTIDVDDLNEL 98
ND4L MTH00001
NADH dehydrogenase subunit 4L; Provisional
 18-97 8.12e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177099  Cd Length: 99  Bit Score: 32.73  E-value: 8.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139416989 18 GALIYRSHLMSSLLCLEGMMLSIFITTTLIALNYNITLSFMFPIIILVFAACEAAVGLALLVTMSNAYGTDYVQNLNLLQ 97
Cdd:MTH00001  19 GIILNRGHFIIMLVSIELVLLSTFFLFLINSIEIDLLIEQIFTIMGLTIAAAESAIGLAIMVAYYRIRGTISLKSLNSLR 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH