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Conserved domains on  [gi|1191447779|gb|AQY77332|]
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NOTCH4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1615-1819 4.49e-40

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 151.26  E-value: 4.49e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1615 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrSRQTAVDART 1694
Cdd:COG0666     72 LLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL-EAGADVNAQD 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1695 EDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREG 1774
Cdd:COG0666    151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1191447779 1775 AVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1819
Cdd:COG0666    231 NLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1427-1511 2.24e-29

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


:

Pssm-ID: 411988  Cd Length: 92  Bit Score: 113.26  E-value: 2.24e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1427 AVHPHAGTAPP---ANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQsaPHRRRPPLGED 1503
Cdd:cd21705      7 AVTVEEAEKDPqlvAAQLPWPLVCSSVAGVLALVLGALLGVQLIRRRQREHGALWLPPGFARHRDPN--PHRRREPVGED 84


                   ....*...
gi 1191447779 1504 SIGLKALK 1511
Cdd:cd21705     85 AIGLKPLK 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 428-469 4.29e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 4.29e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1191447779  428 DLDECLMaqqgPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCE 469
Cdd:cd00054      1 DIDECAS----GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1245-1281 5.24e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 50.60  E-value: 5.24e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191447779 1245 PACTPAYdqyCHDHFHNGHCEKGCNTAECGWDGGDCR 1281
Cdd:pfam00066    2 PNCPYPY---CWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 547-583 1.61e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.61e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1191447779  547 DIDECRS-SPCANGGQCQDQPGAFHCKCLPGFEGPRCQ 583
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 310-349 5.22e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 5.22e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1191447779  310 DVDECETQGPphCRNGGTCQNSAGSFHCVCVSGWGGTSCE 349
Cdd:cd00054      1 DIDECASGNP--CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1207-1242 8.47e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.14  E-value: 8.47e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447779 1207 WKGCPsHSRCWLLFRDGQCHPQCDSEECLFDGYDCE 1242
Cdd:pfam00066    1 WPNCP-YPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA pfam07645
Calcium-binding EGF domain;
190-221 1.94e-06

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.08  E-value: 1.94e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1191447779  190 DVNECFQDPGPCPKGTSCHNTLGSFQCLCPVG 221
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 511-545 2.90e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.90e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447779  511 NECASA-PCLNHADCHDLLNGFQCICLPGFSGTRCE 545
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-1000 3.71e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.71e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447779  966 DACQSQ-PCHNHGTCTPKPGGFHCACPPGFVGLRCE 1000
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 765-799 1.13e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 1.13e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447779  765 DYCVSA-PCFNGGTCVNRPGTFSCLCAMGFQGPRCE 799
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 586-621 2.49e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.49e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191447779  586 VDECLS-DPCPVGASCLDLPGAFFCLCPSGFTGQLCE 621
Cdd:cd00054      2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 471-507 5.79e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 5.79e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1191447779  471 DHNECLSQ-PCHPGSTCLDLLATFHCLCPPGLEGQLCE 507
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1164-1200 1.43e-04

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 40.59  E-value: 1.43e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191447779 1164 PRCQKPGakgCEGRSGDGACDAGCSGPGGNWDGGDCS 1200
Cdd:pfam00066    2 PNCPYPY---CWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 927-961 2.90e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 2.90e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447779  927 VNPCESR-PCQNGATCMAQPSGYLCQCAPGYDGQNC 961
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
NOD super family cl08449
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1291-1340 4.49e-04

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


The actual alignment was detected with superfamily member pfam06816:

Pssm-ID: 462014  Cd Length: 56  Bit Score: 39.80  E-value: 4.49e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1191447779 1291 PSLAL----LVVLSPP-ALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPG 1340
Cdd:pfam06816    2 EKLAEgvlvIVVLMDPeELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 732-761 8.64e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 8.64e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447779  732 GPCLNGGSCNPSPGGYYCTCPPSHTGPQCQ 761
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 695-722 1.27e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.27e-03
                           10        20
                   ....*....|....*....|....*...
gi 1191447779  695 PCAHGGTCYPQPSGYNCTCPTGYTGPTC 722
Cdd:cd00054     10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 895-924 1.50e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.50e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447779  895 SLCHNGGLCVDSGPSYFCHCPPGFQGSLCQ 924
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NODP super family cl06639
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1375-1416 1.94e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


The actual alignment was detected with superfamily member pfam07684:

Pssm-ID: 462229  Cd Length: 59  Bit Score: 38.41  E-value: 1.94e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1191447779 1375 AGFVVVMGVDLSRCGPDHpaSRCPWDPGLLLRFLAAMAAVGA 1416
Cdd:pfam07684    2 IGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKGG 41
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 360-386 3.78e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.78e-03
                           10        20
                   ....*....|....*....|....*..
gi 1191447779  360 CAPGSTCIDRVGSFSCLCPPGRTGLLC 386
Cdd:cd00054     11 CQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 809-838 4.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.18e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447779  809 SPCRNRATCQDSPQGPRCLCPTGYTGGSCQ 838
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 276-304 9.45e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 9.45e-03
                           10        20
                   ....*....|....*....|....*....
gi 1191447779  276 CVSHQCQNGGTCQDGLDTYTCLCPETWTG 304
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1043-1080 9.74e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 9.74e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1191447779 1043 IDPCHSQ-PCFHGGTCEATAGSplgFICHCPKGFEGPTC 1080
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGS---YRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1615-1819 4.49e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 151.26  E-value: 4.49e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1615 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrSRQTAVDART 1694
Cdd:COG0666     72 LLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL-EAGADVNAQD 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1695 EDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREG 1774
Cdd:COG0666    151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1191447779 1775 AVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1819
Cdd:COG0666    231 NLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1427-1511 2.24e-29

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411988  Cd Length: 92  Bit Score: 113.26  E-value: 2.24e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1427 AVHPHAGTAPP---ANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQsaPHRRRPPLGED 1503
Cdd:cd21705      7 AVTVEEAEKDPqlvAAQLPWPLVCSSVAGVLALVLGALLGVQLIRRRQREHGALWLPPGFARHRDPN--PHRRREPVGED 84


                   ....*...
gi 1191447779 1504 SIGLKALK 1511
Cdd:cd21705     85 AIGLKPLK 92
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1634-1727 5.51e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 5.51e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1634 LHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDartEDGTTPLMLAARLAVEDLV 1713
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 1191447779 1714 EELIAAQADVGARD 1727
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1615-1787 1.25e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.95  E-value: 1.25e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1615 LLDGGACPQaHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDART 1694
Cdd:PHA02875    21 LLDIGINPN-FEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFY 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1695 EDGTTPLMLAARLAVEDLVEELIA--AQADVGARDKWgkTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAR 1772
Cdd:PHA02875   100 KDGMTPLHLATILKKLDIMKLLIArgADPDIPNTDKF--SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMA 177

                          170
                   ....*....|....*
gi 1191447779 1773 EGAVEVAQLLLGLGA 1787
Cdd:PHA02875   178 KGDIAICKMLLDSGA 192
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1630-1783 2.57e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 58.87  E-value: 2.57e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1630 GETPLHLAARFSRPTAARRLLEAGanP---NQPDR----AGRTPLHAAVAADAREVCQLLLRSRQTAVDARTED------ 1696
Cdd:cd22192     51 GETALHVAALYDNLEAAVVLMEAA--PelvNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSPRATGtffrpg 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1697 -------GTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARS----LLQAGADKDAQ------ 1759
Cdd:cd22192    129 pknliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQmydlILSYDKEDDLQpldlvp 208

                          170       180
                   ....*....|....*....|....
gi 1191447779 1760 DNREQTPLFLAAREGAVEVAQLLL 1783
Cdd:cd22192    209 NNQGLTPFKLAAKEGNIVMFQHLV 232
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 428-469 4.29e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 4.29e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1191447779  428 DLDECLMaqqgPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCE 469
Cdd:cd00054      1 DIDECAS----GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1245-1281 5.24e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 50.60  E-value: 5.24e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191447779 1245 PACTPAYdqyCHDHFHNGHCEKGCNTAECGWDGGDCR 1281
Cdd:pfam00066    2 PNCPYPY---CWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 547-583 1.61e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.61e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1191447779  547 DIDECRS-SPCANGGQCQDQPGAFHCKCLPGFEGPRCQ 583
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
428-469 2.28e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 2.28e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1191447779   428 DLDECLMaqqgPSPCEHGGSCLNTPGSFNCLCPPGYT-GSRCE 469
Cdd:smart00179    1 DIDECAS----GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1240-1280 3.10e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.48  E-value: 3.10e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1191447779  1240 DCETPPACTpayDQYCHDHFHNGHCEKGCNTAECGWDGGDC 1280
Cdd:smart00004    1 PQDPWSRCE---DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 310-349 5.22e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 5.22e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1191447779  310 DVDECETQGPphCRNGGTCQNSAGSFHCVCVSGWGGTSCE 349
Cdd:cd00054      1 DIDECASGNP--CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1207-1242 8.47e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.14  E-value: 8.47e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447779 1207 WKGCPsHSRCWLLFRDGQCHPQCDSEECLFDGYDCE 1242
Cdd:pfam00066    1 WPNCP-YPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA pfam07645
Calcium-binding EGF domain;
190-221 1.94e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.08  E-value: 1.94e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1191447779  190 DVNECFQDPGPCPKGTSCHNTLGSFQCLCPVG 221
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1203-1241 2.76e-06

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 45.78  E-value: 2.76e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447779  1203 VPDPWKGCPsHSRCWLLFRDGQCHPQCDSEECLFDGYDC 1241
Cdd:smart00004    1 PQDPWSRCE-DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 511-545 2.90e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.90e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447779  511 NECASA-PCLNHADCHDLLNGFQCICLPGFSGTRCE 545
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
547-583 3.69e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.69e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447779   547 DIDECRS-SPCANGGQCQDQPGAFHCKCLPGFE-GPRCQ 583
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-1000 3.71e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.71e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447779  966 DACQSQ-PCHNHGTCTPKPGGFHCACPPGFVGLRCE 1000
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
310-349 5.41e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 5.41e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1191447779   310 DVDECETQGPphCRNGGTCQNSAGSFHCVCVSGW-GGTSCE 349
Cdd:smart00179    1 DIDECASGNP--CQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 190-228 5.94e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.94e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1191447779  190 DVNECfQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCE 228
Cdd:cd00054      1 DIDEC-ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 765-799 1.13e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 1.13e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447779  765 DYCVSA-PCFNGGTCVNRPGTFSCLCAMGFQGPRCE 799
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
190-228 1.42e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.42e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1191447779   190 DVNECfQDPGPCPKGTSCHNTLGSFQCLCPVG-QEGPRCE 228
Cdd:smart00179    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 586-621 2.49e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.49e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191447779  586 VDECLS-DPCPVGASCLDLPGAFFCLCPSGFTGQLCE 621
Cdd:cd00054      2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 471-507 5.79e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 5.79e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1191447779  471 DHNECLSQ-PCHPGSTCLDLLATFHCLCPPGLEGQLCE 507
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
511-545 5.88e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 5.88e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191447779   511 NECASA-PCLNHADCHDLLNGFQCICLPGFS-GTRCE 545
Cdd:smart00179    3 DECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
310-342 1.28e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 1.28e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1191447779  310 DVDECETqGPPHCRNGGTCQNSAGSFHCVCVSG 342
Cdd:pfam07645    1 DVDECAT-GTHNCPANTVCVNTIGSFECRCPDG 32
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1164-1200 1.43e-04

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 40.59  E-value: 1.43e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191447779 1164 PRCQKPGakgCEGRSGDGACDAGCSGPGGNWDGGDCS 1200
Cdd:pfam00066    2 PNCPYPY---CWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 968-998 1.58e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 1.58e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1191447779  968 CQSQPCHNHGTCTPKPGGFHCACPPGFVGLR 998
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
765-799 2.05e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 2.05e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191447779   765 DYCVSA-PCFNGGTCVNRPGTFSCLCAMGFQ-GPRCE 799
Cdd:smart00179    3 DECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1161-1199 2.15e-04

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 40.39  E-value: 2.15e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447779  1161 SPGPRCQkpgAKGCEGRSGDGACDAGCSGPGGNWDGGDC 1199
Cdd:smart00004    3 DPWSRCE---DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 927-961 2.90e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 2.90e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447779  927 VNPCESR-PCQNGATCMAQPSGYLCQCAPGYDGQNC 961
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
966-1000 3.38e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.38e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191447779   966 DACQS-QPCHNHGTCTPKPGGFHCACPPGFV-GLRCE 1000
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
428-462 4.03e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.53  E-value: 4.03e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1191447779  428 DLDECLmaqQGPSPCEHGGSCLNTPGSFNCLCPPG 462
Cdd:pfam07645    1 DVDECA---TGTHNCPANTVCVNTIGSFECRCPDG 32
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1291-1340 4.49e-04

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 39.80  E-value: 4.49e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1191447779 1291 PSLAL----LVVLSPP-ALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPG 1340
Cdd:pfam06816    2 EKLAEgvlvIVVLMDPeELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 767-797 6.20e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.20e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1191447779  767 CVSAPCFNGGTCVNRPGTFSCLCAMGFQGPR 797
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 732-761 8.64e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 8.64e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447779  732 GPCLNGGSCNPSPGGYYCTCPPSHTGPQCQ 761
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
585-621 8.96e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 8.96e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447779   585 EVDECLS-DPCPVGASCLDLPGAFFCLCPSGFT-GQLCE 621
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
471-507 1.10e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.10e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447779   471 DHNECLS-QPCHPGSTCLDLLATFHCLCPPGLE-GQLCE 507
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 695-722 1.27e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.27e-03
                           10        20
                   ....*....|....*....|....*...
gi 1191447779  695 PCAHGGTCYPQPSGYNCTCPTGYTGPTC 722
Cdd:cd00054     10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 895-924 1.50e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.50e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447779  895 SLCHNGGLCVDSGPSYFCHCPPGFQGSLCQ 924
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1375-1416 1.94e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 38.41  E-value: 1.94e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1191447779 1375 AGFVVVMGVDLSRCGPDHpaSRCPWDPGLLLRFLAAMAAVGA 1416
Cdd:pfam07684    2 IGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKGG 41
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 930-960 2.53e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.53e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1191447779  930 CESRPCQNGATCMAQPSGYLCQCAPGYDGQN 960
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 729-759 2.68e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.68e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1191447779  729 CHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQ 759
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
927-961 3.48e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 3.48e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191447779   927 VNPCESR-PCQNGATCMAQPSGYLCQCAPGY-DGQNC 961
Cdd:smart00179    2 IDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 360-386 3.78e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.78e-03
                           10        20
                   ....*....|....*....|....*..
gi 1191447779  360 CAPGSTCIDRVGSFSCLCPPGRTGLLC 386
Cdd:cd00054     11 CQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 809-838 4.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.18e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447779  809 SPCRNRATCQDSPQGPRCLCPTGYTGGSCQ 838
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 806-834 6.83e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 6.83e-03
                           10        20
                   ....*....|....*....|....*....
gi 1191447779  806 CADSPCRNRATCQDSPQGPRCLCPTGYTG 834
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 276-304 9.45e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 9.45e-03
                           10        20
                   ....*....|....*....|....*....
gi 1191447779  276 CVSHQCQNGGTCQDGLDTYTCLCPETWTG 304
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1043-1080 9.74e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 9.74e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1191447779 1043 IDPCHSQ-PCFHGGTCEATAGSplgFICHCPKGFEGPTC 1080
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGS---YRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1615-1819 4.49e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 151.26  E-value: 4.49e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1615 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrSRQTAVDART 1694
Cdd:COG0666     72 LLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL-EAGADVNAQD 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1695 EDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREG 1774
Cdd:COG0666    151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1191447779 1775 AVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1819
Cdd:COG0666    231 NLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1630-1819 2.56e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 143.17  E-value: 2.56e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1630 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrSRQTAVDARTEDGTTPLMLAARLAV 1709
Cdd:COG0666     54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLL-EAGADVNARDKDGETPLHLAAYNGN 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1710 EDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAAR 1789
Cdd:COG0666    133 LEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212

                          170       180       190
                   ....*....|....*....|....*....|
gi 1191447779 1790 ELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1819
Cdd:COG0666    213 NAKDNDGKTALDLAAENGNLEIVKLLLEAG 242
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1573-1800 4.73e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 139.32  E-value: 4.73e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1573 APDLDTRGPDGVTPLMSAVCCGEVQSGTFqgawlgcpepwepLLDGGACPQAHTVGtGETPLHLAARFSRPTAARRLLEA 1652
Cdd:COG0666     77 GADINAKDDGGNTLLHAAARNGDLEIVKL-------------LLEAGADVNARDKD-GETPLHLAAYNGNLEIVKLLLEA 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1653 GANPNQPDRAGRTPLHAAVAADAREVCQLLLrSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKT 1732
Cdd:COG0666    143 GADVNAQDNDGNTPLHLAAANGNLEIVKLLL-EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKT 221

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191447779 1733 ALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPA 1800
Cdd:COG0666    222 ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1427-1511 2.24e-29

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411988  Cd Length: 92  Bit Score: 113.26  E-value: 2.24e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1427 AVHPHAGTAPP---ANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQsaPHRRRPPLGED 1503
Cdd:cd21705      7 AVTVEEAEKDPqlvAAQLPWPLVCSSVAGVLALVLGALLGVQLIRRRQREHGALWLPPGFARHRDPN--PHRRREPVGED 84


                   ....*...
gi 1191447779 1504 SIGLKALK 1511
Cdd:cd21705     85 AIGLKPLK 92
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1634-1819 5.77e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.90  E-value: 5.77e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1634 LHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLV 1713
Cdd:COG0666     24 LLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIV 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1714 EELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRD 1793
Cdd:COG0666    104 KLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARD 183

                          170       180
                   ....*....|....*....|....*.
gi 1191447779 1794 QAGLAPADVAHQRNHWDLLTLLEGAG 1819
Cdd:COG0666    184 NDGETPLHLAAENGHLEIVKLLLEAG 209
JMTM_Notch cd21701
juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus ...
 1427-1510 1.05e-19

juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus notch homolog (Notch) proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. They operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch proteins, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411984  Cd Length: 85  Bit Score: 85.12  E-value: 1.05e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1427 AVHPHAGTAPPAnQLPWPVLCSPVAGVILLALGALLVLQLIRRRRReHGALWLPPGFTRRPRTQsaPHRRRPPLGEDSIG 1506
Cdd:cd21701      6 SVRSEPGPATKT-TPPAQLSPLVVAAVCVLLVLVVLGVLVARKRRR-HGTLWFPEGFPRTRASR--RSRRRDPVGQDSVG 81


                   ....
gi 1191447779 1507 LKAL 1510
Cdd:cd21701     82 LKNL 85
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1649-1819 9.86e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 85.78  E-value: 9.86e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1649 LLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDK 1728
Cdd:COG0666      6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1729 WGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNH 1808
Cdd:COG0666     86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                          170
                   ....*....|.
gi 1191447779 1809 WDLLTLLEGAG 1819
Cdd:COG0666    166 LEIVKLLLEAG 176
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1634-1727 5.51e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 5.51e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1634 LHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDartEDGTTPLMLAARLAVEDLV 1713
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 1191447779 1714 EELIAAQADVGARD 1727
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1615-1787 1.25e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.95  E-value: 1.25e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1615 LLDGGACPQaHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDART 1694
Cdd:PHA02875    21 LLDIGINPN-FEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFY 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1695 EDGTTPLMLAARLAVEDLVEELIA--AQADVGARDKWgkTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAR 1772
Cdd:PHA02875   100 KDGMTPLHLATILKKLDIMKLLIArgADPDIPNTDKF--SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMA 177

                          170
                   ....*....|....*
gi 1191447779 1773 EGAVEVAQLLLGLGA 1787
Cdd:PHA02875   178 KGDIAICKMLLDSGA 192
JMTM_Notch1 cd21702
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1468-1511 3.42e-12

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411985  Cd Length: 80  Bit Score: 63.66  E-value: 3.42e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1191447779 1468 RRRRREHGALWLPPGFTrrpRTQSAPHRRRPPLGEDSIGLKALK 1511
Cdd:cd21702     39 RKRRREHGQLWFPEGFK---VSEPSKKKRREPVGEDSVGLKPLK 79
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1615-1773 1.54e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 69.14  E-value: 1.54e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1615 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSrQTAVDART 1694
Cdd:PHA02878   153 LLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLEN-GASTDARD 231

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1695 EDGTTPLMLA-ARLAVEDLVEELIAAQADVGARDK-WGKTALHwaAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAR 1772
Cdd:PHA02878   232 KCGNTPLHISvGYCKDYDILKLLLEHGVDVNAKSYiLGLTALH--SSIKSERKLKLLLEYGADINSLNSYKLTPLSSAVK 309


                   .
gi 1191447779 1773 E 1773
Cdd:PHA02878   310 Q 310
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1647-1787 2.41e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 2.41e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1647 RRLLEAGANPNQPDRAGRTPLHAAVA---ADAREVCQLLLRSrQTAVDARTEDGTTPLMLAARLA-VEDLVEELIAAQAD 1722
Cdd:PHA03095    31 RRLLAAGADVNFRGEYGKTPLHLYLHyssEKVKDIVRLLLEA-GADVNAPERCGFTPLHLYLYNAtTLDVIKLLIKAGAD 109

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191447779 1723 VGARDKWGKTALHWAAAVNNARAA--RSLLQAGADKDAQDNREQTPL--FLAAREGAVEVAQLLLGLGA 1787
Cdd:PHA03095   110 VNAKDKVGRTPLHVYLSGFNINPKviRLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLIDAGA 178
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1574-1823 2.54e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 2.54e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1574 PDLDTRGPDGVTPLMSAVCCGEVQsgtfqgawlgCPEPWEPLLDGGACPQAHTVgTGETPLHLAARFS-RPTAARRLLEA 1652
Cdd:PHA03095    38 ADVNFRGEYGKTPLHLYLHYSSEK----------VKDIVRLLLEAGADVNAPER-CGFTPLHLYLYNAtTLDVIKLLIKA 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1653 GANPNQPDRAGRTPLHA-----AVAADareVCQLLLRsRQTAVDARTEDGTTPL----------------MLAA---RLA 1708
Cdd:PHA03095   107 GADVNAKDKVGRTPLHVylsgfNINPK---VIRLLLR-KGADVNALDLYGMTPLavllksrnanvellrlLIDAgadVYA 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1709 VED------------------LVEELIAAQADVGARDKWGKTALHWAAAVNNARAA--RSLLQAGADKDAQDNREQTPLF 1768
Cdd:PHA03095   183 VDDrfrsllhhhlqsfkprarIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSlvLPLLIAGISINARNRYGQTPLH 262

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1191447779 1769 LAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLL-TLLEGAGPPEA 1823
Cdd:PHA03095   263 YAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVrAALAKNPSAET 318
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1701-1787 4.66e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 4.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1701 LMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWaAAVNNARAARSLLQAGADKDAQDNReQTPLFLAAREGAVEVAQ 1780
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHL-AAKNGHLEIVKLLLEHADVNLKDNG-RTALHYAARSGHLEIVK 78


                   ....*..
gi 1191447779 1781 LLLGLGA 1787
Cdd:pfam12796   79 LLLEKGA 85
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1667-1760 1.42e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 59.36  E-value: 1.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1667 LHAAVAADAREVCQLLLRSRqTAVDARTEDGTTPLMLAARLAVEDLVEELIAaQADVGARDKwGKTALHWAAAVNNARAA 1746
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 1191447779 1747 RSLLQAGADKDAQD 1760
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1615-1692 8.54e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 63.76  E-value: 8.54e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191447779 1615 LLDGGACPQAHTVgTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDA 1692
Cdd:PTZ00322   101 LLTGGADPNCRDY-DGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177
JMTM_Notch2 cd21703
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1469-1510 8.93e-10

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins; Neurogenic locus notch homolog protein 2 (Notch2) functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch2 is involved in bone remodeling and homeostasis. In collaboration with RELA/p65, it enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Notch2 positively regulates self-renewal of liver cancer cells. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch2, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411986  Cd Length: 82  Bit Score: 57.08  E-value: 8.93e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1191447779 1469 RRRREHGALWLPPGFTrrPRTQSAPHRRRPPLGEDSIGLKAL 1510
Cdd:cd21703     43 KRKRKHGPLWFPEGFI--LNKENSNRKRREPVGQDAVGMKNL 82
Ank_4 pfam13637
Ankyrin repeats (many copies);
1632-1683 2.31e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.97  E-value: 2.31e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1191447779 1632 TPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLL 1683
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1681-1819 3.93e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.97  E-value: 3.93e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1681 LLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQD 1760
Cdd:COG0666      5 LLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKD 84

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1191447779 1761 NREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1819
Cdd:COG0666     85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAG 143
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1615-1820 7.23e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 60.45  E-value: 7.23e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1615 LLDGGACPQAHTVGTgETPLHLAARF-----SRPTAARRLLEAGANPNQPDRAGRTPLHAAVAadaREVCQL----LLRS 1685
Cdd:PHA03100    54 LLDNGADINSSTKNN-STPLHYLSNIkynltDVKEIVKLLLEYGANVNAPDNNGITPLLYAIS---KKSNSYsiveYLLD 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1686 RQTAVDARTEDGTTPLMLAARLAVEDL--VEELIAAQADVGARDKwgktalhwaaavnnaraARSLLQAGADKDAQDNRE 1763
Cdd:PHA03100   130 NGANVNIKNSDGENLLHLYLESNKIDLkiLKLLIDKGVDINAKNR-----------------VNYLLSYGVPINIKDVYG 192

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1191447779 1764 QTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGP 1820
Cdd:PHA03100   193 FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1649-1794 1.41e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 60.08  E-value: 1.41e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1649 LLEAGANPNQPDRAGRTPLHAAVAADA--REVCQLLlrSRQTAVDARTEDGTTPLMLAARLAVE-DLVEELIAAQADVGA 1725
Cdd:PHA02876   259 LYDAGFSVNSIDDCKNTPLHHASQAPSlsRLVPKLL--ERGADVNAKNIKGETPLYLMAKNGYDtENIRTLIMLGADVNA 336

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1726 RDKWGKTALHWAAAVNNARAAR-SLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQ 1794
Cdd:PHA02876   337 ADRLYITPLHQASTLDRNKDIViTLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQ 406
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1630-1783 2.57e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 58.87  E-value: 2.57e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1630 GETPLHLAARFSRPTAARRLLEAGanP---NQPDR----AGRTPLHAAVAADAREVCQLLLRSRQTAVDARTED------ 1696
Cdd:cd22192     51 GETALHVAALYDNLEAAVVLMEAA--PelvNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSPRATGtffrpg 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1697 -------GTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARS----LLQAGADKDAQ------ 1759
Cdd:cd22192    129 pknliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQmydlILSYDKEDDLQpldlvp 208

                          170       180
                   ....*....|....*....|....
gi 1191447779 1760 DNREQTPLFLAAREGAVEVAQLLL 1783
Cdd:cd22192    209 NNQGLTPFKLAAKEGNIVMFQHLV 232
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 428-469 4.29e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 4.29e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1191447779  428 DLDECLMaqqgPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCE 469
Cdd:cd00054      1 DIDECAS----GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1245-1281 5.24e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 50.60  E-value: 5.24e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191447779 1245 PACTPAYdqyCHDHFHNGHCEKGCNTAECGWDGGDCR 1281
Cdd:pfam00066    2 PNCPYPY---CWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 547-583 1.61e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.61e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1191447779  547 DIDECRS-SPCANGGQCQDQPGAFHCKCLPGFEGPRCQ 583
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
428-469 2.28e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 2.28e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1191447779   428 DLDECLMaqqgPSPCEHGGSCLNTPGSFNCLCPPGYT-GSRCE 469
Cdd:smart00179    1 DIDECAS----GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1240-1280 3.10e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.48  E-value: 3.10e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1191447779  1240 DCETPPACTpayDQYCHDHFHNGHCEKGCNTAECGWDGGDC 1280
Cdd:smart00004    1 PQDPWSRCE---DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 310-349 5.22e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 5.22e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1191447779  310 DVDECETQGPphCRNGGTCQNSAGSFHCVCVSGWGGTSCE 349
Cdd:cd00054      1 DIDECASGNP--CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1207-1242 8.47e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.14  E-value: 8.47e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447779 1207 WKGCPsHSRCWLLFRDGQCHPQCDSEECLFDGYDCE 1242
Cdd:pfam00066    1 WPNCP-YPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
JMTM_Notch3 cd21704
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1467-1508 9.51e-07

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411987  Cd Length: 90  Bit Score: 48.59  E-value: 9.51e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1191447779 1467 IRRRRREHGALWLPPGFTRrpRTQSAPHRRRPPLGEDSIGLK 1508
Cdd:cd21704     47 VARRKREHSTLWFPEGFFL--KKESSNKNRREPVGQDALGMK 86
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1749-1847 9.53e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.13  E-value: 9.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1749 LLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLL----------EGA 1818
Cdd:PTZ00322   101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLsrhsqchfelGAN 180

                           90       100
                   ....*....|....*....|....*....
gi 1191447779 1819 GPPEARHKATPGREAGPFPRARTVSVSVP 1847
Cdd:PTZ00322   181 AKPDSFTGKPPSLEDSPISSHHPDFSAVP 209
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1613-1824 1.27e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.53  E-value: 1.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1613 EPLLDGGACPQAHTVGTgETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLlrsrqtaVDA 1692
Cdd:PHA02876   162 EMLLEGGADVNAKDIYC-ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAI-------IDN 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1693 RTEDGTTPLMLAARLAVEDLVEELIAAQA--DVGARDKWGKTALHWAAAVNN-ARAARSLLQAGADKDAQDNREQTPLFL 1769
Cdd:PHA02876   234 RSNINKNDLSLLKAIRNEDLETSLLLYDAgfSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYL 313

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1191447779 1770 AAREG-AVEVAQLLLGLGAARELRDQAGLAPADVAH--QRNHWDLLTLLEGAGPPEAR 1824
Cdd:PHA02876   314 MAKNGyDTENIRTLIMLGADVNAADRLYITPLHQAStlDRNKDIVITLLELGANVNAR 371
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1632-1770 1.50e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.53  E-value: 1.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1632 TPLHLAARfsRPTAAR---RLLEAGANPNQPDRAGRTPLH--AAVAADAREVCQLLlrSRQTAVDARTEDGTTPLMLAAR 1706
Cdd:PHA02876   275 TPLHHASQ--APSLSRlvpKLLERGADVNAKNIKGETPLYlmAKNGYDTENIRTLI--MLGADVNAADRLYITPLHQAST 350

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1191447779 1707 L-AVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLA 1770
Cdd:PHA02876   351 LdRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFA 415
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1615-1793 1.68e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.14  E-value: 1.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1615 LLDGGACPQAHTVgTGETPLHLAARFSRPTA-ARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDAR 1693
Cdd:PHA02876   293 LLERGADVNAKNI-KGETPLYLMAKNGYDTEnIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLLELGANVNAR 371

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1694 TEDGTTPLMLAA--------------RLAVEDL--------------------VEELIAAQADVGARDKWGKTALHWAAA 1739
Cdd:PHA02876   372 DYCDKTPIHYAAvrnnvviintlldyGADIEALsqkigtalhfalcgtnpymsVKTLIDRGANVNSKNKDLSTPLHYACK 451

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1191447779 1740 VNNARAARS-LLQAGADKDAQDNREQTPLFLAAreGAVEVAQLLLGLGAarELRD 1793
Cdd:PHA02876   452 KNCKLDVIEmLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGA--ELRD 502
Ank_5 pfam13857
Ankyrin repeats (many copies);
1615-1670 1.92e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.57  E-value: 1.92e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1191447779 1615 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAA 1670
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
EGF_CA pfam07645
Calcium-binding EGF domain;
190-221 1.94e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.08  E-value: 1.94e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1191447779  190 DVNECFQDPGPCPKGTSCHNTLGSFQCLCPVG 221
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1203-1241 2.76e-06

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 45.78  E-value: 2.76e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447779  1203 VPDPWKGCPsHSRCWLLFRDGQCHPQCDSEECLFDGYDC 1241
Cdd:smart00004    1 PQDPWSRCE-DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 511-545 2.90e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.90e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447779  511 NECASA-PCLNHADCHDLLNGFQCICLPGFSGTRCE 545
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
547-583 3.69e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.69e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447779   547 DIDECRS-SPCANGGQCQDQPGAFHCKCLPGFE-GPRCQ 583
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-1000 3.71e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.71e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447779  966 DACQSQ-PCHNHGTCTPKPGGFHCACPPGFVGLRCE 1000
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
310-349 5.41e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 5.41e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1191447779   310 DVDECETQGPphCRNGGTCQNSAGSFHCVCVSGW-GGTSCE 349
Cdd:smart00179    1 DIDECASGNP--CQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 190-228 5.94e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.94e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1191447779  190 DVNECfQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCE 228
Cdd:cd00054      1 DIDEC-ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1575-1660 6.37e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 46.26  E-value: 6.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1575 DLDTRGPDGVTPLMSAVCCGEVQSGTFqgawlgcpepwepLLDggaCPQAHTVGTGETPLHLAARFSRPTAARRLLEAGA 1654
Cdd:pfam12796   22 DANLQDKNGRTALHLAAKNGHLEIVKL-------------LLE---HADVNLKDNGRTALHYAARSGHLEIVKLLLEKGA 85


                   ....*.
gi 1191447779 1655 NPNQPD 1660
Cdd:pfam12796   86 DINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1630-1689 1.03e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 50.05  E-value: 1.03e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1630 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTA 1689
Cdd:PHA03100   192 GFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSI 251
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1749-1815 1.11e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.49  E-value: 1.11e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191447779 1749 LLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARElrDQAGLAPADVAHQRNHWDLLTLL 1815
Cdd:pfam12796   16 LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVKLL 80
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 765-799 1.13e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 1.13e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447779  765 DYCVSA-PCFNGGTCVNRPGTFSCLCAMGFQGPRCE 799
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
190-228 1.42e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.42e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1191447779   190 DVNECfQDPGPCPKGTSCHNTLGSFQCLCPVG-QEGPRCE 228
Cdd:smart00179    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1635-1716 1.58e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.90  E-value: 1.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1635 HLAARfSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLR--SRQTAVDartEDGTTPLMLAARLAVEDL 1712
Cdd:PTZ00322    88 QLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEfgADPTLLD---KDGKTPLELAEENGFREV 163


                   ....
gi 1191447779 1713 VEEL 1716
Cdd:PTZ00322   164 VQLL 167
Ank_5 pfam13857
Ankyrin repeats (many copies);
1649-1704 2.03e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.87  E-value: 2.03e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1191447779 1649 LLEAG-ANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQtAVDARTEDGTTPLMLA 1704
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGV-DLNLKDEEGLTALDLA 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 586-621 2.49e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.49e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191447779  586 VDECLS-DPCPVGASCLDLPGAFFCLCPSGFTGQLCE 621
Cdd:cd00054      2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02946 PHA02946
ankyin-like protein; Provisional
 1613-1783 4.19e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 48.51  E-value: 4.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1613 EPLLDGGACPQaHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAR--EVCQLLLRSRQTAV 1690
Cdd:PHA02946    56 EELLHRGYSPN-ETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEviERINLLVQYGAKIN 134

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1691 DARTEDGTTPLmLAARLAVEDLVEELIAAQADVGARDKWGKTAL--HWAAAVNNARAARSLLQAGADKDAQDNREQTPLF 1768
Cdd:PHA02946   135 NSVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLH 213

                          170
                   ....*....|....*..
gi 1191447779 1769 LAAREGA--VEVAQLLL 1783
Cdd:PHA02946   214 IVCSKTVknVDIINLLL 230
Ank_5 pfam13857
Ankyrin repeats (many copies);
1682-1735 5.20e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 5.20e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1191447779 1682 LLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALH 1735
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 471-507 5.79e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 5.79e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1191447779  471 DHNECLSQ-PCHPGSTCLDLLATFHCLCPPGLEGQLCE 507
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
511-545 5.88e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 5.88e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191447779   511 NECASA-PCLNHADCHDLLNGFQCICLPGFS-GTRCE 545
Cdd:smart00179    3 DECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1632-1799 1.15e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 46.88  E-value: 1.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1632 TPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrsrqtavdartEDGTTPLMLAARLAVED 1711
Cdd:PHA02874    37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI-----------DNGVDTSILPIPCIEKD 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1712 LVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAAREL 1791
Cdd:PHA02874   106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANV 185


                   ....*...
gi 1191447779 1792 RDQAGLAP 1799
Cdd:PHA02874   186 KDNNGESP 193
EGF_CA pfam07645
Calcium-binding EGF domain;
310-342 1.28e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 1.28e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1191447779  310 DVDECETqGPPHCRNGGTCQNSAGSFHCVCVSG 342
Cdd:pfam07645    1 DVDECAT-GTHNCPANTVCVNTIGSFECRCPDG 32
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1164-1200 1.43e-04

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 40.59  E-value: 1.43e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191447779 1164 PRCQKPGakgCEGRSGDGACDAGCSGPGGNWDGGDCS 1200
Cdd:pfam00066    2 PNCPYPY---CWDKFGNGVCDEECNNAECLWDGGDCS 35
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1630-1661 1.57e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.74  E-value: 1.57e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1191447779 1630 GETPLHLAA-RFSRPTAARRLLEAGANPNQPDR 1661
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 968-998 1.58e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 1.58e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1191447779  968 CQSQPCHNHGTCTPKPGGFHCACPPGFVGLR 998
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
765-799 2.05e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 2.05e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191447779   765 DYCVSA-PCFNGGTCVNRPGTFSCLCAMGFQ-GPRCE 799
Cdd:smart00179    3 DECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1161-1199 2.15e-04

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 40.39  E-value: 2.15e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447779  1161 SPGPRCQkpgAKGCEGRSGDGACDAGCSGPGGNWDGGDC 1199
Cdd:smart00004    3 DPWSRCE---DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1633-1815 2.90e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 45.64  E-value: 2.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1633 PLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRS-------------------------RQ 1687
Cdd:PHA02878    40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSinkcsvfytlvaikdafnnrnveifKI 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1688 TAVDARTEDGTTPLMLAARLAVEDLVEE-----LIAAQADVGARDK-WGKTALHWAAAVNNARAARSLLQAGADKDAQDN 1761
Cdd:PHA02878   120 ILTNRYKNIQTIDLVYIDKKSKDDIIEAeitklLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDK 199

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1191447779 1762 REQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQR-NHWDLLTLL 1815
Cdd:PHA02878   200 TNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLL 254
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 927-961 2.90e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 2.90e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191447779  927 VNPCESR-PCQNGATCMAQPSGYLCQCAPGYDGQNC 961
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
966-1000 3.38e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.38e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191447779   966 DACQS-QPCHNHGTCTPKPGGFHCACPPGFV-GLRCE 1000
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
428-462 4.03e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.53  E-value: 4.03e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1191447779  428 DLDECLmaqQGPSPCEHGGSCLNTPGSFNCLCPPG 462
Cdd:pfam07645    1 DVDECA---TGTHNCPANTVCVNTIGSFECRCPDG 32
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1291-1340 4.49e-04

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 39.80  E-value: 4.49e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1191447779 1291 PSLAL----LVVLSPP-ALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPG 1340
Cdd:pfam06816    2 EKLAEgvlvIVVLMDPeELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1716-1784 4.57e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 4.57e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191447779 1716 LIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLG 1784
Cdd:PTZ00322   101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 767-797 6.20e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.20e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1191447779  767 CVSAPCFNGGTCVNRPGTFSCLCAMGFQGPR 797
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Ank_5 pfam13857
Ankyrin repeats (many copies);
1749-1803 6.26e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.64  E-value: 6.26e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1191447779 1749 LLQAG-ADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVA 1803
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 439-467 6.94e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.00  E-value: 6.94e-04
                           10        20
                   ....*....|....*....|....*....
gi 1191447779  439 PSPCEHGGSCLNTPGSFNCLCPPGYTGSR 467
Cdd:cd00053      5 SNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 439-467 7.85e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 7.85e-04
                           10        20
                   ....*....|....*....|....*....
gi 1191447779  439 PSPCEHGGSCLNTPGSFNCLCPPGYTGSR 467
Cdd:pfam00008    3 PNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1630-1657 8.41e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.39  E-value: 8.41e-04
                           10        20
                   ....*....|....*....|....*...
gi 1191447779 1630 GETPLHLAARFSRPTAARRLLEAGANPN 1657
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 732-761 8.64e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 8.64e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447779  732 GPCLNGGSCNPSPGGYYCTCPPSHTGPQCQ 761
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
585-621 8.96e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 8.96e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447779   585 EVDECLS-DPCPVGASCLDLPGAFFCLCPSGFT-GQLCE 621
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1629-1783 1.05e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 44.10  E-value: 1.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1629 TGETPLHLAARFSRPT---AARRLLEAGANPNQPDR-----------AGRTPLHAAVAADAREVCQLLLrSRQTAVDART 1694
Cdd:cd21882     25 TGKTCLHKAALNLNDGvneAIMLLLEAAPDSGNPKElvnapctdefyQGQTALHIAIENRNLNLVRLLV-ENGADVSARA 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1695 ED-------------GTTPLMLAARLAVEDLVEELI---AAQADVGARDKWGKTALHWAAAVNNARAARS---------L 1749
Cdd:cd21882    104 TGrffrkspgnlfyfGELPLSLAACTNQEEIVRLLLengAQPAALEAQDSLGNTVLHALVLQADNTPENSafvcqmynlL 183

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1191447779 1750 LQAGADKDAQDNREQ-------TPLFLAAREGAVEVAQLLL 1783
Cdd:cd21882    184 LSYGAHLDPTQQLEEipnhqglTPLKLAAVEGKIVMFQHIL 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
471-507 1.10e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.10e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1191447779   471 DHNECLS-QPCHPGSTCLDLLATFHCLCPPGLE-GQLCE 507
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 1630-1707 1.19e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 44.02  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1630 GETPLHLAARFSRPTAARRLLEagaNPNQP------DRAGRTPLHA--AVAADAREVCQ--------LLLRSRQTAVDAR 1693
Cdd:cd22193    123 GELPLSLAACTNQPDIVQYLLE---NEHQPadieaqDSRGNTVLHAlvTVADNTKENTKfvtrmydmILIRGAKLCPTVE 199

                           90
                   ....*....|....*....
gi 1191447779 1694 TE-----DGTTPLMLAARL 1707
Cdd:cd22193    200 LEeirnnDGLTPLQLAAKM 218
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 695-722 1.27e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.27e-03
                           10        20
                   ....*....|....*....|....*...
gi 1191447779  695 PCAHGGTCYPQPSGYNCTCPTGYTGPTC 722
Cdd:cd00054     10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 895-924 1.50e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.50e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447779  895 SLCHNGGLCVDSGPSYFCHCPPGFQGSLCQ 924
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1630-1772 1.71e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.03  E-value: 1.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1630 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrSRQTAVDARTEDGTTPL---MLAAR 1706
Cdd:PHA02874   157 GCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLI-DHGNHIMNKCKNGFTPLhnaIIHNR 235

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191447779 1707 LAVedlveELIAAQADVGARDKWGKTALHWA-AAVNNARAARSLLQAGADKDAQDNREQTPLFLAAR 1772
Cdd:PHA02874   236 SAI-----ELLINNASINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTAFK 297
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1375-1416 1.94e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 38.41  E-value: 1.94e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1191447779 1375 AGFVVVMGVDLSRCGPDHpaSRCPWDPGLLLRFLAAMAAVGA 1416
Cdd:pfam07684    2 IGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKGG 41
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 969-998 2.17e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 2.17e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447779  969 QSQPCHNHGTCTPKPGGFHCACPPGFVGLR 998
Cdd:cd00053      4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 930-960 2.53e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.53e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1191447779  930 CESRPCQNGATCMAQPSGYLCQCAPGYDGQN 960
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 729-759 2.68e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.68e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1191447779  729 CHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQ 759
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1696-1728 2.78e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 2.78e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1191447779 1696 DGTTPLMLAA-RLAVEDLVEELIAAQADVGARDK 1728
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1649-1787 2.83e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.93  E-value: 2.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1649 LLEAGANPNQPDRAGRTPLHAAvAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEEL--IAAQADVGAr 1726
Cdd:PLN03192   544 LLKAKLDPDIGDSKGRTPLHIA-ASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILyhFASISDPHA- 621

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1191447779 1727 dkwGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGA 1787
Cdd:PLN03192   622 ---AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGA 679
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1631-1803 3.09e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.26  E-value: 3.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1631 ETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAvDARTEDGTTPLMLAARLAVE 1710
Cdd:PHA02874   125 KTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYA-NVKDNNGESPLHNAAEYGDY 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1711 DLVEELIAAQADVGARDKWGKTALHwaAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAR-EGAVEVAQLLLGLGAAR 1789
Cdd:PHA02874   204 ACIKLLIDHGNHIMNKCKNGFTPLH--NAIIHNRSAIELLINNASINDQDIDGSTPLHHAINpPCDIDIIDILLYHKADI 281

                          170
                   ....*....|....
gi 1191447779 1790 ELRDQAGLAPADVA 1803
Cdd:PHA02874   282 SIKDNKGENPIDTA 295
EGF_CA smart00179
Calcium-binding EGF-like domain;
927-961 3.48e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 3.48e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1191447779   927 VNPCESR-PCQNGATCMAQPSGYLCQCAPGY-DGQNC 961
Cdd:smart00179    2 IDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
Ank_4 pfam13637
Ankyrin repeats (many copies);
1732-1783 3.64e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.25  E-value: 3.64e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1191447779 1732 TALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLL 1783
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 360-386 3.78e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.78e-03
                           10        20
                   ....*....|....*....|....*..
gi 1191447779  360 CAPGSTCIDRVGSFSCLCPPGRTGLLC 386
Cdd:cd00054     11 CQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1629-1758 3.96e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.16  E-value: 3.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1629 TGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrsrQTAVDARTEDGTTPLMLAARLA 1708
Cdd:PLN03192   557 KGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY---HFASISDPHAAGDLLCTAAKRN 633

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1709 VEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDA 1758
Cdd:PLN03192   634 DLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDK 683
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 809-838 4.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.18e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1191447779  809 SPCRNRATCQDSPQGPRCLCPTGYTGGSCQ 838
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1649-1770 4.83e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.49  E-value: 4.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1649 LLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRqTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDK 1728
Cdd:PHA02874   110 ILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYG-ADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDN 188

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1191447779 1729 WGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLA 1770
Cdd:PHA02874   189 NGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNA 230
COG3903 COG3903
Predicted ATPase [General function prediction only];
1660-1844 5.03e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443109 [Multi-domain]  Cd Length: 933  Bit Score: 41.93  E-value: 5.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1660 DRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAA 1739
Cdd:COG3903      3 AAAAAAAAAAAAALALLALAAAAAAAAAAAALAAALEALRAALALLLLLLAALALALAALALLLAAAALLLRLLLLLLAA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1740 VNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1819
Cdd:COG3903     83 RLLARLAAAAAAALARAAAAALALLLRLRLAARRLLLARALAAAALAAAAAAAAAAAAAPAPPPPAPPPPAPLAALARRA 162

                          170       180
                   ....*....|....*....|....*
gi 1191447779 1820 PPEARhkatpgREAGPFPRARTVSV 1844
Cdd:COG3903    163 AALAA------AARALLSAARLVTL 181
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 806-834 6.83e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 6.83e-03
                           10        20
                   ....*....|....*....|....*....
gi 1191447779  806 CADSPCRNRATCQDSPQGPRCLCPTGYTG 834
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 1615-1707 7.11e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 41.28  E-value: 7.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1615 LLDGGACPQAHTVGT-------------GETPLHLAARFSRPTAARRLLEAGANP-NQPDRAGRTPLHAAV-AADAREVC 1679
Cdd:cd22194    160 LIAKGADVNAHAKGVffnpkykhegfyfGETPLALAACTNQPEIVQLLMEKESTDiTSQDSRGNTVLHALVtVAEDSKTQ 239

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1191447779 1680 ---------QLLLRSRQTAVDA-RTEDGTTPLMLAARL 1707
Cdd:cd22194    240 ndfvkrmydMILLKSENKNLETiRNNEGLTPLQLAAKM 277
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1701-1796 9.28e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.78  E-value: 9.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191447779 1701 LMLAARLAVEDlVEELIAAQADVGARDKWGKTALHWAAAVNNARAA---RSLLQAGADKDAQDNREQTPLFLAAREGAVE 1777
Cdd:PHA03095    19 LLNASNVTVEE-VRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKdivRLLLEAGADVNAPERCGFTPLHLYLYNATTL 97

                           90       100
                   ....*....|....*....|
gi 1191447779 1778 -VAQLLLGLGAARELRDQAG 1796
Cdd:PHA03095    98 dVIKLLIKAGADVNAKDKVG 117
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 276-304 9.45e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 9.45e-03
                           10        20
                   ....*....|....*....|....*....
gi 1191447779  276 CVSHQCQNGGTCQDGLDTYTCLCPETWTG 304
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1043-1080 9.74e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 9.74e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1191447779 1043 IDPCHSQ-PCFHGGTCEATAGSplgFICHCPKGFEGPTC 1080
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGS---YRCSCPPGYTGRNC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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