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Conserved domains on  [gi|1189039218|gb|ARN85439|]
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ApaG [Candidatus Nucleicultrix amoebiphila FS5]

Protein Classification

Co(2+)/Mg(2+) efflux protein ApaG( domain architecture ID 10006820)

Co(2+)/Mg(2+) efflux protein ApaG adopts a fibronectin type III (FN3) fold

CATH:  2.60.40.1470
Gene Ontology:  GO:0005515
SCOP:  4007551

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ApaG COG2967
Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport [Inorganic ion transport ...
 10-126 2.05e-41

Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism];


:

Pssm-ID: 442207  Cd Length: 119  Bit Score: 133.30  E-value: 2.05e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189039218  10 HSVIVTVKVQFVEEESLPNGPHYVWAYHINIQNQSVETLQLLRRFWRIVDATGYVEEVEGEGVVGEMPILAPGESYQYTS 89
Cdd:COG2967     1 YGIKVSVETEYLPEQSDPEEGRYVFAYTITIENLGDVTVQLLSRHWIITDANGKVQEVEGEGVVGEQPVLAPGESFEYTS 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1189039218  90 GVPLNTPSGIMGGYYEMETQDERTIKILIPTFVLNSP 126
Cdd:COG2967    81 GCVLETPVGTMQGSYQMVDEDGERFDVPIPPFSLAAP 117
 
Name Accession Description Interval E-value
ApaG COG2967
Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport [Inorganic ion transport ...
 10-126 2.05e-41

Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism];


Pssm-ID: 442207  Cd Length: 119  Bit Score: 133.30  E-value: 2.05e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189039218  10 HSVIVTVKVQFVEEESLPNGPHYVWAYHINIQNQSVETLQLLRRFWRIVDATGYVEEVEGEGVVGEMPILAPGESYQYTS 89
Cdd:COG2967     1 YGIKVSVETEYLPEQSDPEEGRYVFAYTITIENLGDVTVQLLSRHWIITDANGKVQEVEGEGVVGEQPVLAPGESFEYTS 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1189039218  90 GVPLNTPSGIMGGYYEMETQDERTIKILIPTFVLNSP 126
Cdd:COG2967    81 GCVLETPVGTMQGSYQMVDEDGERFDVPIPPFSLAAP 117
apaG PRK05461
CO2+/MG2+ efflux protein ApaG; Reviewed
 9-126 2.56e-38

CO2+/MG2+ efflux protein ApaG; Reviewed


Pssm-ID: 180098  Cd Length: 127  Bit Score: 125.64  E-value: 2.56e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189039218   9 SHSVIVTVKVQFVEEESLPNGPHYVWAYHINIQNQSVETLQLLRRFWRIVDATGYVEEVEGEGVVGEMPILAPGESYQYT 88
Cdd:PRK05461    6 TYGIEVSVQPRYLEEQSDPEEGRYVFAYTITIENLGRVPVQLLSRHWLITDANGRVQEVRGEGVVGEQPVLAPGESFEYT 85

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1189039218  89 SGVPLNTPSGIMGGYYEMETQDERTIKILIPTFVLNSP 126
Cdd:PRK05461   86 SGAVLETPSGTMQGHYQMVDEDGERFEVPIPPFRLAVP 123
DUF525 pfam04379
ApaG domain; The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins ...
 22-108 1.97e-28

ApaG domain; The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins and in eukaryotic F-box proteins. The domain is named after the bacterial apaG protein, of which it forms the core. The domain also occurs in the C-terminal part of eukaryotic proteins with an N-terminal F-box domain. The Salmonella typhimurium apaG domain protein corD is involved in Co(2+) resistance and Mg(2+) efflux. Tertiary structures from different apaG proteins show a fold of several beta-sheets. The apaG domain may be involved in protein-protein interactions which could be implicated in substrate-specificity.


Pssm-ID: 461283  Cd Length: 87  Bit Score: 99.46  E-value: 1.97e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189039218  22 EEESLPNGPHYVWAYHINIQNQSVETLQLLRRFWRIVDATGYVEEVEGEGVVGEMPILAPGESYQYTSGVPLNTPSGIMG 101
Cdd:pfam04379   1 PEQSSPEEGRYVFAYTIRIENLGDSSVQLLSRHWIITDANGKVEEVRGEGVVGEQPVLAPGESFEYTSGCPLETPSGSME 80


                  ....*..
gi 1189039218 102 GYYEMET 108
Cdd:pfam04379  81 GSYTMVR 87
 
Name Accession Description Interval E-value
ApaG COG2967
Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport [Inorganic ion transport ...
 10-126 2.05e-41

Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism];


Pssm-ID: 442207  Cd Length: 119  Bit Score: 133.30  E-value: 2.05e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189039218  10 HSVIVTVKVQFVEEESLPNGPHYVWAYHINIQNQSVETLQLLRRFWRIVDATGYVEEVEGEGVVGEMPILAPGESYQYTS 89
Cdd:COG2967     1 YGIKVSVETEYLPEQSDPEEGRYVFAYTITIENLGDVTVQLLSRHWIITDANGKVQEVEGEGVVGEQPVLAPGESFEYTS 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1189039218  90 GVPLNTPSGIMGGYYEMETQDERTIKILIPTFVLNSP 126
Cdd:COG2967    81 GCVLETPVGTMQGSYQMVDEDGERFDVPIPPFSLAAP 117
apaG PRK05461
CO2+/MG2+ efflux protein ApaG; Reviewed
 9-126 2.56e-38

CO2+/MG2+ efflux protein ApaG; Reviewed


Pssm-ID: 180098  Cd Length: 127  Bit Score: 125.64  E-value: 2.56e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189039218   9 SHSVIVTVKVQFVEEESLPNGPHYVWAYHINIQNQSVETLQLLRRFWRIVDATGYVEEVEGEGVVGEMPILAPGESYQYT 88
Cdd:PRK05461    6 TYGIEVSVQPRYLEEQSDPEEGRYVFAYTITIENLGRVPVQLLSRHWLITDANGRVQEVRGEGVVGEQPVLAPGESFEYT 85

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1189039218  89 SGVPLNTPSGIMGGYYEMETQDERTIKILIPTFVLNSP 126
Cdd:PRK05461   86 SGAVLETPSGTMQGHYQMVDEDGERFEVPIPPFRLAVP 123
DUF525 pfam04379
ApaG domain; The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins ...
 22-108 1.97e-28

ApaG domain; The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins and in eukaryotic F-box proteins. The domain is named after the bacterial apaG protein, of which it forms the core. The domain also occurs in the C-terminal part of eukaryotic proteins with an N-terminal F-box domain. The Salmonella typhimurium apaG domain protein corD is involved in Co(2+) resistance and Mg(2+) efflux. Tertiary structures from different apaG proteins show a fold of several beta-sheets. The apaG domain may be involved in protein-protein interactions which could be implicated in substrate-specificity.


Pssm-ID: 461283  Cd Length: 87  Bit Score: 99.46  E-value: 1.97e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189039218  22 EEESLPNGPHYVWAYHINIQNQSVETLQLLRRFWRIVDATGYVEEVEGEGVVGEMPILAPGESYQYTSGVPLNTPSGIMG 101
Cdd:pfam04379   1 PEQSSPEEGRYVFAYTIRIENLGDSSVQLLSRHWIITDANGKVEEVRGEGVVGEQPVLAPGESFEYTSGCPLETPSGSME 80


                  ....*..
gi 1189039218 102 GYYEMET 108
Cdd:pfam04379  81 GSYTMVR 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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