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Conserved domains on  [gi|1210962690|gb|ASE36505|]
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cyclic lactone autoinducer peptide [Staphylococcus pettenkoferi]

Protein Classification

cyclic lactone autoinducer peptide( domain architecture ID 10655109)

cyclic lactone autoinducer peptide similar to Staphylococcal AgrD protein, the precursor of the autoinducing peptide (AIP), which, by the action of AgrB, interacts with AgrC in the membrane to activate AgrA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AgrD smart00794
Staphylococcal AgrD protein; This family consists of several AgrD proteins from many ...
 1-45 2.26e-15

Staphylococcal AgrD protein; This family consists of several AgrD proteins from many Staphylococcus species. The agr locus was initially described in Staphylococcus aureus as an element controlling the production of exoproteins implicated in virulence. Its pattern of action has been shown to be complex, upregulating certain extracellular toxins and enzymes expressed post-exponentially and repressing some exponential-phase surface components. AgrD encodes the precursor of the autoinducing peptide (AIP).The AIP derived from AgrD by the action of AgrB interacts with AgrC in the membrane to activate AgrA, which upregulates transcription both from promoter P2, amplifying the response, and from P3, initiating the production of a novel effector: RNAIII. In S. aureus, delta-hemolysin is the only translation product of RNA III and is not involved in the regulatory functions of the transcript, which is therefore the primary agent for modulating the expression of other operons controlled by agr.


:

Pssm-ID: 129030  Cd Length: 45  Bit Score: 61.51  E-value: 2.26e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1210962690   1 MKLINIFFKILITSFSILGKQSGVYPCGGWWDEPEVPKEITDLHK 45
Cdd:smart00794  1 MNLLNLIFKLFTKFFESIGNVAGYNPCTGYFDEPEVPKELTDLYE 45
 
Name Accession Description Interval E-value
AgrD smart00794
Staphylococcal AgrD protein; This family consists of several AgrD proteins from many ...
 1-45 2.26e-15

Staphylococcal AgrD protein; This family consists of several AgrD proteins from many Staphylococcus species. The agr locus was initially described in Staphylococcus aureus as an element controlling the production of exoproteins implicated in virulence. Its pattern of action has been shown to be complex, upregulating certain extracellular toxins and enzymes expressed post-exponentially and repressing some exponential-phase surface components. AgrD encodes the precursor of the autoinducing peptide (AIP).The AIP derived from AgrD by the action of AgrB interacts with AgrC in the membrane to activate AgrA, which upregulates transcription both from promoter P2, amplifying the response, and from P3, initiating the production of a novel effector: RNAIII. In S. aureus, delta-hemolysin is the only translation product of RNA III and is not involved in the regulatory functions of the transcript, which is therefore the primary agent for modulating the expression of other operons controlled by agr.


Pssm-ID: 129030  Cd Length: 45  Bit Score: 61.51  E-value: 2.26e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1210962690   1 MKLINIFFKILITSFSILGKQSGVYPCGGWWDEPEVPKEITDLHK 45
Cdd:smart00794  1 MNLLNLIFKLFTKFFESIGNVAGYNPCTGYFDEPEVPKELTDLYE 45
AgrD pfam05931
Staphylococcal AgrD protein; This family consists of several AgrD proteins from many ...
 3-45 2.04e-07

Staphylococcal AgrD protein; This family consists of several AgrD proteins from many Staphylococcus species. The agr locus was initially described in Staphylococcus aureus as an element controlling the production of exoproteins implicated in virulence. Its pattern of action has been shown to be complex, upregulating certain extracellular toxins and enzymes expressed post-exponentially and repressing some exponential-phase surface components. AgrD encodes the precursor of the autoinducing peptide (AIP).The AIP derived from AgrD by the action of AgrB interacts with AgrC in the membrane to activate AgrA, which upregulates transcription both from promoter P2, amplifying the response, and from P3, initiating the production of a novel effector: RNAIII. In S. aureus, delta-hemolysin is the only translation product of RNA III and is not involved in the regulatory functions of the transcript, which is therefore the primary agent for modulating the expression of other operons controlled by agr.


Pssm-ID: 368676  Cd Length: 45  Bit Score: 41.43  E-value: 2.04e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 1210962690  3 LINIFFKILITSFSILGKQSGVYPCGGWWDEPEVPKEITDLHK 45
Cdd:pfam05931  3 IFNLFFDFFTGILEFIGNIAADSTCAFIFDEPEVPEELTKLHE 45
quorum_AgrD TIGR04223
cyclic lactone autoinducer peptide; Members of this family of short peptides are precursors to ...
 5-41 6.95e-05

cyclic lactone autoinducer peptide; Members of this family of short peptides are precursors to thiolactone (unless Cys is replaced by Ser) cyclic autoinducer peptides, used in quorum-sensing systems in Gram-positive bacteria. The best characterized is the AgrD precursor, processed by the AgrB protein. Nearby proteins regularly encountered include a histidine kinase and a response regulator. This model is related to pfam05931 but is newer and currently broader in scope.


Pssm-ID: 275064  Cd Length: 37  Bit Score: 34.80  E-value: 6.95e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 1210962690  5 NIFFKILITSFSILGKQSGVYPCGGWWDEPEVPKEIT 41
Cdd:TIGR04223  1 KKILKLLAKLALKVATVAANSACWFILYQPKVPEELK 37
 
Name Accession Description Interval E-value
AgrD smart00794
Staphylococcal AgrD protein; This family consists of several AgrD proteins from many ...
 1-45 2.26e-15

Staphylococcal AgrD protein; This family consists of several AgrD proteins from many Staphylococcus species. The agr locus was initially described in Staphylococcus aureus as an element controlling the production of exoproteins implicated in virulence. Its pattern of action has been shown to be complex, upregulating certain extracellular toxins and enzymes expressed post-exponentially and repressing some exponential-phase surface components. AgrD encodes the precursor of the autoinducing peptide (AIP).The AIP derived from AgrD by the action of AgrB interacts with AgrC in the membrane to activate AgrA, which upregulates transcription both from promoter P2, amplifying the response, and from P3, initiating the production of a novel effector: RNAIII. In S. aureus, delta-hemolysin is the only translation product of RNA III and is not involved in the regulatory functions of the transcript, which is therefore the primary agent for modulating the expression of other operons controlled by agr.


Pssm-ID: 129030  Cd Length: 45  Bit Score: 61.51  E-value: 2.26e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1210962690   1 MKLINIFFKILITSFSILGKQSGVYPCGGWWDEPEVPKEITDLHK 45
Cdd:smart00794  1 MNLLNLIFKLFTKFFESIGNVAGYNPCTGYFDEPEVPKELTDLYE 45
AgrD pfam05931
Staphylococcal AgrD protein; This family consists of several AgrD proteins from many ...
 3-45 2.04e-07

Staphylococcal AgrD protein; This family consists of several AgrD proteins from many Staphylococcus species. The agr locus was initially described in Staphylococcus aureus as an element controlling the production of exoproteins implicated in virulence. Its pattern of action has been shown to be complex, upregulating certain extracellular toxins and enzymes expressed post-exponentially and repressing some exponential-phase surface components. AgrD encodes the precursor of the autoinducing peptide (AIP).The AIP derived from AgrD by the action of AgrB interacts with AgrC in the membrane to activate AgrA, which upregulates transcription both from promoter P2, amplifying the response, and from P3, initiating the production of a novel effector: RNAIII. In S. aureus, delta-hemolysin is the only translation product of RNA III and is not involved in the regulatory functions of the transcript, which is therefore the primary agent for modulating the expression of other operons controlled by agr.


Pssm-ID: 368676  Cd Length: 45  Bit Score: 41.43  E-value: 2.04e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 1210962690  3 LINIFFKILITSFSILGKQSGVYPCGGWWDEPEVPKEITDLHK 45
Cdd:pfam05931  3 IFNLFFDFFTGILEFIGNIAADSTCAFIFDEPEVPEELTKLHE 45
quorum_AgrD TIGR04223
cyclic lactone autoinducer peptide; Members of this family of short peptides are precursors to ...
 5-41 6.95e-05

cyclic lactone autoinducer peptide; Members of this family of short peptides are precursors to thiolactone (unless Cys is replaced by Ser) cyclic autoinducer peptides, used in quorum-sensing systems in Gram-positive bacteria. The best characterized is the AgrD precursor, processed by the AgrB protein. Nearby proteins regularly encountered include a histidine kinase and a response regulator. This model is related to pfam05931 but is newer and currently broader in scope.


Pssm-ID: 275064  Cd Length: 37  Bit Score: 34.80  E-value: 6.95e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 1210962690  5 NIFFKILITSFSILGKQSGVYPCGGWWDEPEVPKEIT 41
Cdd:TIGR04223  1 KKILKLLAKLALKVATVAANSACWFILYQPKVPEELK 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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